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https://www.readbyqxmd.com/read/29665388/expression-and-characterization-of-novel-laccase-gene-from-pandoraea-sp-istkb-and-its-application
#1
Madan Kumar, Arti Mishra, Shashi Shekhar Singh, Shaili Srivastava, Indu Shekhar Thakur
In the present study, a non-blue laccase gene from previously reported lignin degrading bacterium, Pandoraea sp. ISTKB, was isolated, cloned and expressed in E. coli. Bioinformatics analysis of sequence discovered twin-arginine translocation signal sequence, copper binding motifs and presence of more random coil compare to helices and sheets in structure. The enzyme was found to be active on wide pH range and the pH optima was observed at pH 4 and 8 on substrate 2,2'-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) and 2,6-Dimethoxyphenol respectively...
April 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29663495/three-dimensional-mapping-of-the-joint-space-for-the-diagnosis-of-knee-osteoarthritis-based-on-high-resolution-computed-tomography-comparison-with-radiographic-outerbridge-and-meniscal-classifications
#2
Houda Mezlini-Gharsallah, Rabaa Youssef, Stéphanie Uk, Jean Denis Laredo, Christine Chappard
One of the most important characteristic of knee osteoarthritis (OA) is the joint space (JS) width narrowing. Measurements are usually performed on two dimensional (2D) X-rays. We propose and validate a new method to assess the 3D joint space at the medial knee compartment using high resolution peripheral computed tomography images. A semi-automated method was developed to obtain a distance 3D map between femur an tibia with the following parameters: volume, minimum, maximum, mean, standard deviation, median, asymmetry and entropy...
April 16, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29659777/number-of-pregnancies-and-subsequent-phenotype-in-a-cross-sectional-cohort-of-women-with-arrhythmogenic-cardiomyopathy
#3
Anna I Castrini, Øyvind H Lie, Ida S Leren, Mette E Estensen, Mathis K Stokke, Lars G Klæboe, Thor Edvardsen, Kristina H Haugaa
Aims: We aimed to assess the relation between number of pregnancies and cardiac structure, function, and arrhythmic events in women with arrhythmogenic cardiomyopathy (AC). Methods and results: We included female AC patients in a cross-sectional study. Number of pregnancies and pregnancy related symptoms were recorded. Ventricular arrhythmias were defined as aborted cardiac arrest, sustained ventricular tachycardia, or appropriate implantable cardioverter-defibrillator therapy...
April 6, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29658111/architectonic-characteristics-of-the-visual-thalamus-and-superior-colliculus-in-titi-monkeys
#4
Mary Kl Baldwin, Leah Krubitzer
Titi monkeys are arboreal, diurnal New World monkeys whose ancestors were the first surviving branch of the New World radiation. In the current study, we use cytoarchtectonic and immunohistochemical characteristics to compare subcortical structures associated with visual processing with those of other well-studied primates. Our goal was to appreciate features that are similar across all New World monkeys, and primates in general, versus those features that are unique to titi monkeys and other primate taxa. We examined tissue stained for Nissl substance, cytochrome oxidase (CO), acetylcholinesterase (AChE), calbindin (Cb), parvalbumin (Pv), and vesicular glutamate transporter 2 (VGLUT2) to characterize the superior colliculus, lateral geniculate nucleus, and visual pulvinar...
April 15, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29651902/shoulder-and-lower-back-joint-reaction-forces-in-seated-double-poling
#5
Marie Lund Ohlsson, Jonas Danvind, L Joakim Holmberg
Overuse injuries in the shoulders and lower back are hypothesized to be common in cross-country sit-skiing. Athletes with reduced trunk muscle control mainly sits with their knees higher than hips (KH). To reduce spinal flexion, a position with the knees below the hips (KL) was enabled for these athletes using a frontal trunk support. The aim of the study was to compare the shoulder joint (glenohumeral joint) and L4-L5 joint reactions between the sitting positions KL and KH. Five able-bodied female athletes performed submaximal and maximal exercise tests in the sitting positions KL and KH on a ski-ergometer...
April 13, 2018: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/29649197/metronidazole-stewardship-initiative-at-christchurch-hospitals-achievable-with-immediate-benefits
#6
Sharon J Gardiner, Sarah Cl Metcalf, Paul Kl Chin, Matthew P Doogue, Simon C Dalton, Stephen T Chambers
AIMS: To evaluate an antimicrobial stewardship (AMS) initiative to change hospital prescribing practice for metronidazole. METHODS: In October 2015, the Canterbury District Health Board (CDHB) AMS committee changed advice for metronidazole to promote two times daily dosing for most indications, prioritisation of the oral route and avoidance of double anaerobic cover. Adoption of the initiative was facilitated via change in prescribing guidelines, education and ongoing pharmacy support...
April 13, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29648685/association-of-physical-examination-knee-effusion-with-bone-marrow-lesions-cross-sectional-and-longitudinal-analyses-of-a-population-based-cohort
#7
Jolanda Cibere, Ali Guermazi, Savvas Nicolaou, John M Esdaile, Anona Thorne, Joel Singer, Hubert Wong, Jacek A Kopec, Eric C Sayre
OBJECTIVE: To determine the association of physical examination (PE) effusion with prevalence of bone marrow lesions (BML) on MRI, and incidence/progression of BML over 3 years in knee osteoarthritis (OA). METHODS: A population-based cohort with knee pain (N=255) was assessed for PE effusion. On MRI, BML was graded 0-3 (none, mild, moderate, severe), incidence/progression defined as a worsening in the sum of BML scores over six surfaces by ≥1 grade. We analyzed the full cohort and mild disease subsample with Kellgren-Lawrence (KL) grade <3...
April 12, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29642677/selection-response-and-estimation-of-the-genetic-parameters-for-multidimensional-measured-breast-meat-yield-related-traits-in-a-long-term-breeding-pekin-duck-line
#8
Yaxi Xu, Jian Hu, Yunsheng Zhang, Zhanbao Guo, Wei Huang, Ming Xie, Hehe Liu, Shuisheng Hou, Zhengkui Zhou, Chuzhao Lei, Xiaolin Liu
Objective: This study was conducted to estimate the genetic parameters and breeding values of breast meat related traits of Pekin ducks. Selection response was also determined by using ultrasound breast muscle thickness (BMT) measurements in combination with bosom breadth (BB) and keel length (KL) values. Methods: The traits analyzed were breast meat weight (BMW), body weight (BW), breast meat percentage (BMP) and the three parameters of breast meat (BB, KL, and BMT)...
April 12, 2018: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/29627482/assessment-of-statin-induced-interstitial-pneumonia-in-patients-treated-for-hyperlipidemia-using-a-health-insurance-claims-database-in-japan
#9
Kenji Momo, Akiko Takagi, Atsuko Miyaji, Masayoshi Koinuma
PURPOSE: This study aimed to determine the frequency and risk factors for statin-induced interstitial pneumonia (IP). METHOD: We conducted a retrospective cohort study using a large Japanese health insurance claims database. We determined the statin-induced IP incidence in patients treated with statins for hyperlipidemia (n = 194,814) with 12-month screening and 3-month observation periods. Statin-induced IP was defined as: (1) diagnosis with IP (ICD-10 codes: J70...
April 5, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29610629/digital-clubbing-is-associated-with-higher-serum-kl-6-levels-and-lower-pulmonary-function-in-patients-with-interstitial-lung-disease
#10
Kazushige Shiraishi, Torahiko Jinta, Naoki Nishimura, Hiroshi Nakaoka, Ryosuke Tsugitomi, Kohei Okafuji, Atsushi Kitamura, Yutaka Tomishima, Gautam A Deshpande, Tomohide Tamura
Background: Although digital clubbing is a common presentation in patients with interstitial lung disease (ILD), little has been reported regarding its role in assessing patients with ILD. This study evaluated patients with ILD for the presence of clubbing and investigated its association with clinical data. Methods: We evaluated patients with ILD who visited the teaching hospital at which the study was conducted, between October 2014 and January 2015. Clubbing, evaluated using a Vernier caliper for individual patients, was defined as a phalangeal depth ratio > 1...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29605779/a-systematic-comparison-of-two-empirical-gas-liquid-mass-transfer-determination-methodologies-to-characterize-methane-biodegradation-in-stirred-tank-bioreactors
#11
Raul Muñoz, Cenit Soto, Cristal Zuñiga, Sergio Revah
This study aimed at systematically comparing the potential of two empirical methods for the estimation of the volumetric CH4 mass transfer coefficient (kl aCH4 ), namely gassing-out and oxygen transfer rate (OTR), to describe CH4 biodegradation in a fermenter operated with a methanotrophic consortium at 400, 600 and 800 rpm. The kl aCH4 estimated from the OTR methodology accurately predicted the CH4 elimination capacity (EC) under CH4 mass transfer limiting conditions regardless of the stirring rate (∼9% of average error between empirical and estimated ECs)...
March 29, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29605381/type-2-diabetes-patients-have-accelerated-cartilage-matrix-degeneration-compared-to-diabetes-free-controls-data-from-the-osteoarthritis-initiative
#12
Jan Neumann, Felix C Hofmann, Ursula Heilmeier, Walid Ashmeik, Kenneth Tang, Alexandra S Gersing, Benedikt J Schwaiger, Michael C Nevitt, Gabby B Joseph, Nancy E Lane, Charles E McCulloch, Thomas M Link
PURPOSE: Osteoarthritis (OA) and diabetes mellitus (DM) share common risk factors with a potential underlying relationship between both diseases. The purpose of this study was to investigate the longitudinal effects of DM on cartilage deterioration over 24-months with MR-based T2 relaxation time measurements. METHODS: From the Osteoarthritis Initiative cohort 196 diabetics were matched in small sets for age, sex, BMI and Kellgren-Lawrence score with 196 non-diabetic controls...
March 29, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29604296/circulating-cd34-and-cd34-vegfr2-progenitor-cells-are-associated-with-klotho-kl-vs-polymorphism
#13
Maria Skrzypkowska, Bartosz Słomiński, Monika Ryba-Stanisławowska, Piotr Gutknecht, Janusz Siebert
BACKGROUND: KLOTHO is a regulator of endothelial cells activity and integrity. It has been described for the first time because of its anti-aging properties. KLOTHO encoding gene is present in many functional variants in humans, including "KL-VS" variant that has been connected with longevity and cardiovascular disease development. Few mechanisms have been proposed to explain these associations, but none of them focused on cells from CD34+ population. The aim of our study was to investigate influence of KLOTHO KL-VS polymorphism on populations of CD34+ and CD34+VEGFR2+ cells...
March 28, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29600055/clarithromycin-mitigates-radiation-pneumonitis-in-patients-with-lung-cancer-treated-with-stereotactic-body-radiotherapy
#14
Atsuya Takeda, Yuichiro Tsurugai, Naoko Sanuki, Tatsuji Enomoto, Masaharu Shinkai, Tomikazu Mizuno, Yousuke Aoki, Yohei Oku, Takeshi Akiba, Yu Hara, Etsuo Kunieda
Background: Radiation pneumonitis is a critical pulmonary toxicity after irradiation of the lung. Macrolides including clarithromycin (CAM) are antibiotics. They also have immunomodulatory properties and are used to treat respiratory inflammatory diseases. Radiation pneumonitis has similar pathology to them. Adverse reactions to macrolides are few and self-limited. We thus administered CAM to patients with high-risk factors for radiation pneumonitis, and retrospectively investigated whether CAM mitigated radiation pneumonitis following stereotactic body radiotherapy (SBRT)...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29595258/reductive-o-2-binding-at-a-dihydride-complex-leading-to-redox-interconvertible-%C3%AE-1-2-peroxo-and-%C3%AE-1-2-superoxo-dinickel-ii-intermediates
#15
Peng-Cheng Duan, Dennis-Helmut Manz, Sebastian Dechert, Serhiy Demeshko, Franc Meyer
Dioxygen activation at nickel complexes is much less studied than for the biologically more relevant iron or copper systems but promises new reactivity patterns because of the distinct coordination chemistry of nickel. Here we report that a pyrazolate-based dinickel(II) dihydride complex [KL(Ni-H)2 ] (1a) smoothly reacts with O2 via reductive H2 elimination to give the μ-1,2-peroxo dinickel(II) complex [KLNi2 (O2 )] (2a) and, after treatment with dibenzo[18]-crown-6, the separated ion pair [K(DB18C6)][LNi2 (O2 )] (2b); these are the first μ-1,2-peroxo dinickel intermediates to be characterized by X-ray diffraction...
March 29, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29567521/changes-in-the-structural-features-of-osteoarthritis-in-a-year-of-weight-loss
#16
S R Jafarzadeh, M Clancy, J-S Li, C M Apovian, A Guermazi, F Eckstein, D T Felson
OBJECTIVE: In patients undergoing bariatric surgery or medical management for obesity, we assessed whether those experiencing substantial weight loss had changes in innervated knee structures or in cartilage. METHODS: Severely obese patients (body mass index (BMI) ≥35) with knee pain on most days were seen before bariatric surgery or medical weight management and at 1-year follow-up. Examinations included 3T MRI acquired at both time points for semi-quantitative scoring of bone marrow lesions (BML), synovitis, cartilage damage, and for quantitative measurement of cartilage thickness...
March 20, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29562767/synovial-fluid-eotaxin-1-levels-may-reflect-disease-progression-in-primary-knee-osteoarthritis-among-elderly-han-chinese-a-cross-sectional-study
#17
Bei Li, Yi-Li Zhang, Shou-Yi Yu
Objective The CC chemokine family member eotaxin-1, also named chemokine C-C motif ligand 11 (CCL11), has been detected in knee osteoarthritis (OA) and could induce breakdown of cartilage matrix. This study was performed to investigate the plasma and synovial fluid eotaxin-1 levels with the disease progression in elderly Han Chinese with primary knee OA. Design A total of 143 elderly primary knee OA patients and 135 healthy controls were enrolled in the study. The Western Ontario and McMaster Universities Arthritis Index (WOMAC) was performed to evaluate the clinical severity...
March 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29550400/systematic-review-and-meta-analysis-of-the-reliability-and-discriminative-validity-of-cartilage-compositional-mri-in-knee-osteoarthritis
#18
REVIEW
James W MacKay, Samantha B L Low, Toby O Smith, Andoni P Toms, Andrew M McCaskie, Fiona J Gilbert
OBJECTIVE: To assess reliability and discriminative validity of cartilage compositional magnetic resonance imaging (MRI) in knee osteoarthritis (OA). DESIGN: The study was carried out per PRISMA recommendations. We searched MEDLINE and EMBASE (1974 - present) for eligible studies. We performed qualitative synthesis of reliability data. Where data from at least 2 discrimination studies were available, we estimated pooled standardized mean difference (SMD) between subjects with and without OA...
March 14, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29549492/a-novel-biomarker-in-patients-with-knee-osteoarthritis-adropin
#19
Gulsah Gundogdu, Koksal Gundogdu
Adropin is newly discovered peptide hormone. Osteoarthritis (OA) is a kind of joint disease characterized by progressive joint cartilage loss and joint pain. The present study was carried out to investigate adropin and tumor necrosis factor alpha (TNF-α) levels and the relationship between adropin in patients with knee OA classified by Kellgren-Lawrence (KL). A total of 60 knee OA patients and 30 healthy controls were included in this study. KL grading was carried out using the radiographic findings. Demographic characteristics and laboratory parameters were recorded...
March 16, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29548817/baseline-varus-deformity-is-associated-with-increased-joint-loading-and-pain-of-non-operated-knee-two-years-after-unilateral-total-knee-arthroplasty
#20
Du Hyun Ro, Hyuk-Soo Han, Seong Hwan Kim, Yoon-Ho Kwak, Jae-Young Park, Myung Chul Lee
BACKGROUND: The goals of this study were (1) to document the gait pattern of patients with unilateral knee osteoarthritis (OA), (2) to determine the knee adduction moment (KAM) changes in the non-operated knee, and (3) to identify the predictors of change in KAM in the non-operated knee. METHODS: The study recruited 23 patients with advanced unilateral knee OA. The preoperative Kellgren-Lawrence (KL) grade of the non-operated knee was one or two; non-operated knee pain, rated using a numeric rating scale (NRS), was less than three out of 10 points...
March 2018: Knee
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