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https://www.readbyqxmd.com/read/28821979/the-prognostic-impact-of-combined-pulmonary-fibrosis-and-emphysema-in-patients-with-clinical-stage-ia-non-small-cell-lung-cancer
#1
Tomoyoshi Takenaka, Kiyomi Furuya, Koji Yamazaki, Naoko Miura, Kana Tsutsui, Sadanori Takeo
PURPOSE: We evaluated the long-term outcomes of clinical stage IA non-small cell lung cancer (NSCLC) patients with combined pulmonary fibrosis and emphysema (CPFE) who underwent lobectomy. METHODS: We reviewed the chest computed tomography (CT) findings and divided the patients into normal, fibrosis, emphysema and CPFE groups. We evaluated the relationships among the CT findings, the clinicopathological findings and postoperative survival. RESULTS: The patients were classified into the following groups based on the preoperative chest CT findings: normal lung, n = 187; emphysema, n = 62; fibrosis, n = 8; and CPFE, n = 17...
August 18, 2017: Surgery Today
https://www.readbyqxmd.com/read/28820890/history-based-forward-and-feedback-mechanism-in-cooperative-spectrum-sensing-including-malicious-users-in-cognitive-radio-network
#2
Noor Gul, Ijaz Mansoor Qureshi, Adnan Omar, Atif Elahi, Sajjad Khan
In cognitive radio communication, spectrum sensing plays a vital role in sensing the existence of the primary user (PU). The sensing performance is badly affected by fading and shadowing in case of single secondary user(SU). To overcome this issue, cooperative spectrum sensing (CSS) is proposed. Although the reliability of the system is improved with cooperation but existence of malicious user (MU) in the CSS deteriorates the performance. In this work, we consider the Kullback-Leibler (KL) divergence method for minimizing spectrum sensing data falsification (SSDF) attack...
2017: PloS One
https://www.readbyqxmd.com/read/28812223/prognostic-potential-of-klotho-and-sfrp1-promoter-methylation-in-head-and-neck-squamous-cell-carcinoma
#3
Abeer A Alsofyani, Rawiah A Alsiary, Alaa Samkari, Baraa T Alhaj-Hussain, Jalaluddin Azam Khan, Jaudah Al-Maghrabi, Aisha Elaimi, Mohammed H Al-Qahtani, Adel M Abuzenadah, Ashraf Dallol
Hypermethylation in the CpG island promoter regions of tumor suppressors is known to play a significant role in the development of HNSCC and the detection of which can aid the classification and prognosis of HNSCC. This study aims to profile the methylation patterns in a panel of key genes including CDKN2A, CDKN2B, KLOTHO (KL), RASSF1A, RARB, SLIT2, and SFRP1, in a group of HNSCC samples from Saudi Arabia. The extent of methylation in these genes is determined using the MethyLight assay and correlated with known clinicopathological parameters in our samples of 156 formalin-fixed and paraffin-embedded HNSCC tissues...
August 16, 2017: Journal of Applied Genetics
https://www.readbyqxmd.com/read/28810805/hindfoot-arthritis-progression-and-arthrodesis-risk-after-total-ankle-replacement
#4
Travis J Dekker, David Walton, Emily N Vinson, Kamran S Hamid, Andrew E Federer, Mark E Easley, James K DeOrio, James A Nunley, Samuel B Adams
BACKGROUND: The purpose of this study was to assess the radiographic progression of subtalar and talonavicular degenerative joint disease in a series of patients who had undergone TAA (total ankle arthroplasty) with minimum follow-up of 5 years. METHODS: TAA patient radiographs from a single institution were analyzed for peritalar arthritic changes by extrapolating the modified Kellgren Lawrence (KL) grades of the knee to the subtalar and talonavicular joints. Patients were included if they had a minimum of 5 years of follow-up...
August 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28808345/minimally-invasive-treatment-of-both-column-acetabular-fractures-through-the-stoppa-combined-with-iliac-fossa-approach
#5
Ruipeng Zhang, Yingchao Yin, Shilun Li, Zhiyong Hou, Juan Wang, Wei Chen, Yingze Zhang
Both-column fractures are the most complicated group of acetabular fractures. Although great progress of surgical technique has been made, the choice of approach is controversial. All the fragments could be exposed and managed through combined ilioinguinal and Kocher-Langenbeck (IL+KL) approaches, which has been widely used to conduct the both-column fractures. However, the clinical popularization may be restricted for high rate of complication. Most internal area of the hemipelvis could be exposed through Stoppa combined with iliac fossa (S+IF) approach...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28796175/suppression-of-wnt-signaling-and-osteogenic-changes-in-vascular-smooth-muscle-cells-by-eicosapentaenoic-acid
#6
Yukihiro Saito, Kazufumi Nakamura, Daiji Miura, Kei Yunoki, Toru Miyoshi, Masashi Yoshida, Norifumi Kawakita, Tomonari Kimura, Megumi Kondo, Toshihiro Sarashina, Satoshi Akagi, Atsuyuki Watanabe, Nobuhiro Nishii, Hiroshi Morita, Hiroshi Ito
Vascular medial calcification is often observed in patients with arteriosclerosis. It is also associated with systolic hypertension, wide pulse pressure, and fluctuation of blood pressure, which results in cardiovascular events. Eicosapentaenoic acid (EPA) has been shown to suppress vascular calcification in previous animal experiments. We investigated the inhibitory effects of EPA on Wnt signaling, which is one of the important signaling pathways involved in vascular calcification. Intake of food containing 5% EPA resulted in upregulation of the mRNA expression of Klotho, an intrinsic inhibitor of Wnt signaling, in the kidneys of wild-type mice...
August 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28782699/does-curettage-cement-packing-for-treating-giant-cell-tumors-at-the-knee-lead-to-osteoarthritis
#7
A Caubère, S Harrosch, M Fioravanti, G Curvale, A Rochwerger, J C Mattei
INTRODUCTION: Giant cell tumors (GCTs) make up 15% to 20% of bone-related tumors in adults. They are often found around the knee in the metaphysis and epiphysis area, contacting the joint cartilage. The aims of our study were to evaluate the presence of early knee osteoarthritis (OA) in patients with GCTs in the knee area treated by curettage-cement packing, and to evaluate whether replacing subchondral bone with acrylic cement has an effect on the functional outcomes and quality of life...
August 3, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28780096/effect-of-lignin-linkages-with-other-plant-cell-wall-components-on-in-vitro-and-in-vivo-neutral-detergent-fiber-digestibility-and-rate-of-digestion-of-grass-forages
#8
E Raffrenato, R Fievisohn, K W Cotanch, R J Grant, L E Chase, M E Van Amburgh
The objective of this study was to correlate in vitro and in vivo neutral detergent fiber (NDF) digestibility (NDFD) with the chemical composition of forages and specific chemical linkages, primarily ester- and ether-linked para-coumaric (pCA) and ferulic acids (FA) in forages fed to dairy cattle. The content of acid detergent lignin (ADL) and its relationship with NDF does not fully explain the observed variability in NDFD. The ferulic and p-coumaric acid linkages between ADL and cell wall polysaccharides, rather than the amount of ADL, might be a better predictor of NDFD...
August 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28776751/risk-factors-can-classify-individuals-who-develop-accelerated-knee-osteoarthritis-data-from-the-osteoarthritis-initiative
#9
Jeffrey B Driban, Timothy E McAlindon, Mamta Amin, Lori Lyn Price, Charles B Eaton, Julie E Davis, Bing Lu, Grace H Lo, Jeffrey Duryea, Mary F Barbe
We assessed which combinations of risk factors can classify adults who develop accelerated knee osteoarthritis (KOA) or not and which factors are most important. We conducted a case-control study using data from baseline and the first 4 annual visits of the Osteoarthritis Initiative. Participants had no radiographic KOA at baseline (Kellgren-Lawrence [KL] < 2). We classified 3 groups (matched on sex): 1) accelerated KOA: >1 knee developed advance-stage KOA (KL = 3 or 4) within 48 months, 2) typical KOA: >1 knee increased in radiographic scoring (excluding those with accelerated KOA), and 3) No KOA: no change in KL grade by 48 months...
August 4, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28772621/separation-of-lead-with-a-novel-ion-separating-agent-prepared-by-clothing-a-chitin-whisker-on-a-potassium-tetratitanate-whisker
#10
Juan Liu, Qin-Guo Li, Wen-Jing Xue
Separation of Pb(2+) from Cu(2+)-Pb(2+) mixed solution by a newly-developed ion separating agent was examined, which was obtained by clothing chitin whiskers (ChW) on the surface of potassium tetratitanate whiskers (PTW). The separation capability and mechanism of the ion separating agent (ChW-PTW) was determined, based on the difference of the adsorption isotherm pattern and the adsorption kinetics model between ChW and PTW on Cu(2+) and Pb(2+), respectively. The results showed that the adsorption process of ChW could be described by Freundlish isotherm...
March 6, 2017: Materials
https://www.readbyqxmd.com/read/28772066/varus-thrust-and-incident-and-progressive-knee-osteoarthritis
#11
Leena Sharma, Alison H Chang, Rebecca D Jackson, Michael Nevitt, Kirsten C Moisio, Marc Hochberg, Charles Eaton, C Kent Kwoh, Orit Almagor, Jane Cauley, Joan S Chmiel
BACKGROUND: To determine if varus thrust, bowing-out of the knee during gait, i.e., the first appearance or worsening of varus alignment during stance, is associated with incident and progressive knee osteoarthritis (OA), we undertook an Osteoarthritis Initiative ancillary study. We further considered hypothesized associations adjusted for static alignment, anticipating some attenuation. METHODS: 2-3 trained examiners/site at 4 sites observed gait. In eligible knees, incident OA was analyzed as subsequent incident KL≥2, whole and partial-grade medial joint space narrowing (JSN), and annualized loss of joint space width (JSW), and progression as medial JSN and JSW loss...
August 3, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28763872/-research-of-the-biomarkers-in-pulmonary-and-extrapulmonary-acute-respiratory-distress-syndrome
#12
Q Yang, Z Q Li, H B Lan, S S Xiong, S S Wang, C S Yan
Objective: To explore the biomarkers that applied to pulmonary acute respiratory distress syndrome (ARDS) and extrapulmonary ARDS respectively. Methods: A total of 49 eligible patients with ARDS were selected from Department of Respiratory intensive care unite (ICU) , Department of General ICU and Department of Emergency ICU, the Second Affiliated Hospital of Nanchang University, during April 2015 and February 2016, and divided into pulmonary ARDS group (n=26) and extrapulmonary ARDS group (n=23) according to primary causes...
July 11, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28758524/transit-time-homogenization-in-ischemic-stroke-a-novel-biomarker-of-penumbral-microvascular-failure
#13
Thorbjørn S Engedal, Niels Hjort, Kristina D Hougaard, Claus Z Simonsen, Grethe Andersen, Irene Klærke Mikkelsen, Jens K Boldsen, Simon F Eskildsen, Mikkel B Hansen, Hugo Angleys, Sune N Jespersen, Salvador Pedraza, Tae H Cho, Joaquín Serena, Susanne Siemonsen, Götz Thomalla, Norbert Nighoghossian, Jens Fiehler, Kim Mouridsen, Leif Østergaard
Cerebral ischemia causes widespread capillary no-flow in animal studies. The extent of microvascular impairment in human stroke, however, is unclear. We examined how acute intra-voxel transit time characteristics and subsequent recanalization affect tissue outcome on follow-up MRI in a historic cohort of 126 acute ischemic stroke patients. Based on perfusion-weighted MRI data, we characterized voxel-wise transit times in terms of their mean transit time (MTT), standard deviation (capillary transit time heterogeneity - CTH), and the CTH:MTT ratio (relative transit time heterogeneity), which is expected to remain constant during changes in perfusion pressure in a microvasculature consisting of passive, compliant vessels...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28757188/a-sex-specific-association-between-incident-radiographic-osteoarthritis-of-hip-or-knee-and-incident-peripheral-arterial-calcifications-8-year-prospective-data-from-cohort-hip-and-cohort-knee-check
#14
W P Gielis, P M J Welsing, W E van Spil, J Runhaar, H Weinans, P A de Jong
OBJECTIVES: There is sparse evidence for a relationship between cardiovascular disease (CVD) and osteoarthritis (OA). We investigated the association between incidence of arterial calcifications and incidence of radiographic knee and/or hip OA. DESIGN: We used baseline and 8-year follow-up data of Cohort Hip and Cohort Knee (CHECK). Knees and hips were either Kellgren-Lawrence (KL) grade 0 or 1 at baseline. Arterial calcifications were scored on hip and knee radiographs using a four-grade scale...
July 28, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28750323/differential-use-of-3-cites-by-the-subgenomic-rna-of-pea-enation-mosaic-virus-2
#15
Feng Gao, Anne E Simon
The genomic RNA (gRNA) of Pea enation mosaic virus 2 (PEMV2) is the template for p33 and -1 frameshift product p94. The PEMV2 subgenomic RNA (sgRNA) encodes two overlapping ORFs, p26 and p27, which are required for movement and stability of the gRNA. Efficient translation of p33 requires two of three 3' proximal cap-independent translation enhancers (3'CITEs): the kl-TSS, which binds ribosomes and engages in a long-distance interaction with the 5'end; and the adjacent eIF4E-binding PTE. Unlike the gRNA, all three 3'CITEs were required for efficient translation of the sgRNA, which included the ribosome-binding 3'TSS...
July 24, 2017: Virology
https://www.readbyqxmd.com/read/28749683/control-of-surface-localized-enzyme-assisted-self-assembly-of-peptides-through-catalyzed-oligomerization
#16
Cécile Vigier-Carrière, Déborah Wagner, Alain Chaumont, Baptiste Durr, Paolo Lupattelli, Christophe Lambour, Marc Schmutz, Joseph Hemmerlé, Bernard Senger, Pierre Schaaf, Fouzia Boulmedais, Loïc Jierry
Localized self-assembly allowing both spatial and temporal control over the assembly process is essential in many biological systems. This can be achieved through localized enzyme-assisted self-assembly (LEASA), also called enzyme-instructed self-assembly, where enzymes present on a substrate catalyze a reaction that transforms noninteracting species into self-assembling ones. Very few LEASA systems have been reported so far, and the control of the self-assembly process through the surface properties represents one essential step toward their use, for example, in artificial cell mimicry...
August 7, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28748054/autologous-periodontal-stem-cell-assistance-in-periodontal-regeneration-technique-sai-prt-in-the-treatment-of-periodontal-intrabony-defects-a-case-report-with-one-year-follow-up
#17
Vandana Kl, Haneet Ryana, Priyanka Jairaj Dalvi
Numerous animal and human studies have provided evidence supporting the belief that periodontal ligament stem cells (PDLSCs) can be harnessed for regeneration of periodontal tissues. Based on current literature on the use of ex vivo stem culture and associated problems, this case report describes a novel approach of direct application PDLSCs using stem cell assistance in periodontal regeneration technique (SAI-PRT) for the regeneration of intrabony periodontal defects bypassing ex vivo cultures. SAI-PRT has emerged as a constructive avenue in the treatment of periodontal osseous defects...
2017: Journal of Dental Research, Dental Clinics, Dental Prospects
https://www.readbyqxmd.com/read/28743608/quantitative-regional-and-sub-regional-analysis-of-femoral-and-tibial-subchondral-bone-mineral-density-sbmd-using-computed-tomography-ct-comparison-of-non-osteoarthritic-oa-and-severe-osteoarthritic-knees
#18
P Omoumi, H Babel, B M Jolles, J Favre
OBJECTIVE: This study aimed to compare subchondral bone mineral density (sBMD) between non-radiographic osteoarthritic (OA) and medial femorotibial OA knees, using computed tomography (CT). DESIGN: CT exams from 16 non-radiographic OA (KL grade < 2) and 16 severe medial OA (KL grade ≥ 3) knees (average age of 61.7 ± 3 and 62.2 ± 5 years old respectively, 50% male in each group), were retrospectively analyzed. CT exams were segmented and 3D maps of subchondral BMD (sBMD) based on the CT number in the most superficial 3 mm of femoral and tibial subchondral bone were computed...
July 23, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28738997/removal-kl_abstract
#19
(no author information available yet)
This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Due to an administrative error, an issue was accidentally published here. This has now been removed. The publisher apologises for any inconvenience this may cause.
March 2017: Brain & Development
https://www.readbyqxmd.com/read/28733693/asia-s-first-minimal-access-left-ventricular-assist-device-implantation
#20
Jia Lin Soon, Teing Ee Tan, Choon Pin Lim, David Kl Sim, Hazel Sp Chan, Ka Lee Kerk, Cumaraswamy Sivathasan
No abstract text is available yet for this article.
June 2017: Annals of the Academy of Medicine, Singapore
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