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https://www.readbyqxmd.com/read/29442534/efficacy-and-safety-of-combination-therapy-with-prednisolone-and-oral-tacrolimus-for-progressive-interstitial-pneumonia-with-systemic-sclerosis-a-retrospective-study
#1
Junichi Konma, Takuya Kotani, Takeshi Shoda, Takayasu Suzuka, Youhei Fujiki, Koji Nagai, Kenichiro Hata, Shuzo Yoshida, Tohru Takeuchi, Shigeki Makino, Shigeki Arawaka
OBJECTIVES: We retrospectively investigated efficacy and safety of combination therapy with prednisolone (PSL) and tacrolimus (TAC) for progressive interstitial pneumonitis with systemic sclerosis (SSc-PIP). METHODS: We studied 11 patients with SSc-PIP who received combination therapy with PSL (0.5 mg/kg/day) and TAC (3 mg/day). RESULTS: Baseline Hugh-Jones grades were I, II, III, and IV in 2, 6, 2, and 1 patients, respectively. KL-6 values were elevated to 914 (300-2614) U/mL...
February 14, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29436172/population-pharmacokinetic-pharmacodynamic-pk-pd-modeling-of-depot-testosterone-cypionate-in-healthy-male-subjects
#2
Youwei Bi, Paul J Perry, Michael Ellerby, Daryl J Murry
A randomized, double-blind clinical trial was conducted to investigate long-term abuse effects of testosterone cypionate. Thirty-one healthy males were randomized into a dose group of 100, 250 or 500mg/wk and received 14 weekly injections of TC. A PK-PD model was developed to characterize testosterone concentrations and link exposure to change in luteinizing hormone and spermatogenesis following long-term TC administration. A linear one-compartment model best described the concentration-time profile of total testosterone...
February 13, 2018: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/29431706/prediction-of-sludge-bulking-using-the-knowledge-leverage-based-fuzzy-neural-network
#3
Honggui Han, Zheng Liu, Luming Ge, Junfei Qiao
One of the most important steps and the main bottleneck of the activated sludge wastewater treatment process (WWTP) is the secondary clarification, where sludge bulking is still a widespread problem. In this paper, an intelligent method, based on a knowledge-leverage-based fuzzy neural network (KL-FNN), is developed to predict sludge bulking online. This proposed KL-FNN can make full use of the data and the existing knowledge from the operation of WWTP. Meanwhile, a transfer learning mechanism is applied to adjust the parameters of the proposed method to improve the predicting accuracy...
February 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29431515/different-expression-profiles-of-the-lysyl-oxidases-and-matrix-metalloproteinases-in-human-acl-fibroblasts-after-co-culture-with-synovial-cells
#4
Chunli Wang, Chunming Xu, Rongfu Chen, Li Yang, Kl Paul Sung
Purposes The anterior cruciate ligament (ACL) has poor functional healing response. The synovial tissue surrounding ACL ligament might be a major regulator of the microenvironment in the joint cavity after ACL injury, thus affecting the repair process. Using transwell co-culture, this study explored the direct influence of human synovial cells (HSCs) on ACL fibroblasts (ACLfs) by characterizing the differential expression of the lysyl oxidase family (LOXs) and matrix metalloproteinases (MMP-1, -2, -3), which facilitate extracellular matrix (ECM) repair and degradation, respectively...
February 12, 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29421657/rabbit-models-provide-insights-into-bone-formation-related-biological-process-in-atherosclerotic-vascular-calcification
#5
Linuo Tan, Zhen Wang, Yixue Li
Featured as ectopic mineralization along blood vessels, vascular calcification is a major risk factor for a number of prevalent diseases including atherosclerosis. As recent studies identify vascular calcification as a tightly regulated process recapitulating embryonic bone formation, in this study, RNA-seq data generated from rabbit models with inherited or induced hyperlipidemia and atherosclerosis were used, to investigate bone formation related signals and biology processes in atherosclerotic vascular calcification...
February 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29413509/evaluation-of-the-clinical-characteristics-of-everolimus-induced-lung-injury-and-determination-of-associated-risk-factors
#6
Mitsuhiro Abe, Kenji Tsushima, Jun Ikari, Naoko Kawata, Jiro Terada, Nobuhiro Tanabe, Koichiro Tatsumi
BACKGROUND: Everolimus (ERL), a mammalian target of rapamycin (mTOR) inhibitor, has been used for the management of several advanced cancers. ERL frequently causes lung injury, although the clinical and radiographic features have not been clarified. The aim of this study was to assess the clinical features of ERL-induced lung injury and determine the associated risk factors. METHODS: This single-center, retrospective study included 45 patients (29 men, 16 women; age, 12-78 years) who had received ERL at our hospital between August 2010 and March 2016...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29396281/erectile-dysfunction-and-subclinical-cardiovascular-disease
#7
REVIEW
Martin Miner, Sharon J Parish, Kevin L Billups, Mark Paulos, Mark Sigman, Michael J Blaha
BACKGROUND: An association between erectile dysfunction (ED) and cardiovascular (CV) disease (CVD) has long been recognized, and studies suggest that ED is an independent marker of CVD risk. More significantly, ED is a marker for both obstructive and non-obstructive coronary artery disease (CAD) and may reveal the presence of subclinical CAD in otherwise asymptomatic men. AIM: To discuss the role of ED as an early marker of subclinical CVD; describe an approach to quantifying that burden; and propose an algorithm for the evaluation and management of CV risk in men 40-60 years of age with vasculogenic ED, those presumed to have the highest risk for a CV event...
January 27, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29393256/clinical-course-of-histologically-proven-multifocal-micronodular-pneumocyte-hyperplasia-in-tuberous-sclerosis-complex-a-case-series-and-comparison-with-lymphangiomyomatosis
#8
Satoshi Konno, Masahiko Shigemura, Takahiro Ogi, Kaoruko Shimizu, Masaru Suzuki, Kichizo Kaga, Yasuhiro Hida, Yoshihiro Matsuno, Masaharu Nishimura
BACKGROUND: Multifocal micronodular pneumocyte hyperplasia (MMPH) is a rare pulmonary manifestation of tuberous sclerosis complex (TSC). Because of its rarity, no previous study has described the detailed clinical course of this disease. OBJECTIVES: This study aimed to clarify the longitudinal clinical characteristics of subjects with MMPH. METHODS: Nine patients with MMPH diagnosed at Hokkaido University Hospital were retrospectively analyzed...
January 24, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29390463/a-double-blinded-randomized-placebo-controlled-trial-assessing-the-effects-of-nifedipine-on-embryo-transfer-study-protocol
#9
Kelvin Kl Ng, Genia Rozen, Tanya Stewart, Franca Agresta, Alex Polyakov
INTRODUCTION: Implantation failure is the main factor affecting the success rate of in vitro fertilization (IVF) procedures. Studies have reported that uterine contractions (UCs) at the time of embryo transfer (ET) were inversely related to implantation and pregnancy rate, hence reducing the success of IVF treatment. Various pharmacological agents, with the exception of calcium channel blocker (CCB), have been investigated to reduce UC. In this regard, we are presenting a proposal for a double-blind randomized placebo-controlled trial...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29380495/characterizing-the-distinct-structural-changes-associated-with-self-reported-knee-injury-among-individuals-with-incident-knee-osteoarthritis-data-from-the-osteoarthritis-initiative
#10
Julie E Davis, Matthew S Harkey, Robert J Ward, James W MacKay, Bing Lu, Lori Lyn Price, Charles B Eaton, Mary F Barbe, Grace H Lo, Timothy E McAlindon, Jeffrey B Driban
PURPOSE: We aimed to characterize the agreement between distinct structural changes on magnetic resonance (MR) imaging and self-reported injury in the 12 months leading to incident common or accelerated knee osteoarthritis (KOA). MATERIALS AND METHODS: We conducted a descriptive study using data from baseline and the first 4 annual visits of the Osteoarthritis Initiative. Knees had no radiographic KOA at baseline (Kellgren-Lawrence [KL]<2). We classified 2 groups: 1) accelerated KOA: a knee developed advanced-stage KOA (KL=3 or 4) within 48 months and 2) common KOA: a knee increased in radiographic severity (excluding those with accelerated KOA)...
January 30, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29380241/novel-ethanocycloheptono-3-4-5-kl-benzo-a-xanthene-induces-apoptosis-in-bel-7402-cells
#11
Zhi Jia, Hui-Hui Yang, Yun-Jun Liu, Xiu-Zhen Wang
A novel polycyclic bridged-ring xanthene 2 was synthesized by nucleophilic substitution followed by Michael addition reaction between parent dibenzoxanthene 1 and acetylacetone. The structure of compound 2 was also confirmed by single-crystal X-ray diffraction. We studied the binding activity of this compound with bovine serum albumin (BSA) by fluorescent and UV-visible spectra. The results showed that compound had strong binding ability with BSA. Cell viability in five tumor cell lines was studied by MTT assay...
January 27, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29377599/core-shell-cellulose-based-microspheres-for-oral-administration-of-ketoprofen-lysinate
#12
Vincenzo Guarino, Tania Caputo, Paola Calcagnile, Rosaria Altobelli, Christian Demitri, Luigi Ambrosio
Herein, we propose the fabrication of a new carrier with core/shell structure-inner core of cellulose acetate (CA) coated by a micrometric layer of chitosan (CS)-fabricated through an integrated process, which combines Electro Dynamic Atomization (EDA) and layer-by-layer (LbL) technique. We demonstrate that CA based microspheres possess a unique capability to relevantly retain the drugs-that is, Ketoprofen Lysinate (KL)-along the gastric tract, while providing a massive release along the intestine. CS shell slightly influences the morphology and water retention under different pH conditions, improving drug encapsulation without compromising drug release kinetics...
January 26, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29376887/hypothalamic-loss-of-snord116-recapitulates-the-hyperphagia-of-prader-willi-syndrome
#13
Joseph Polex-Wolf, Brian Yh Lam, Rachel Larder, John Tadross, Debra Rimmington, Fàtima Bosch, Verónica Jiménez Cenzano, Eduard Ayuso, Marcella Kl Ma, Kara Rainbow, Anthony P Coll, Stephen O'Rahilly, Giles Sh Yeo
Profound hyperphagia is a major disabling feature of Prader-Willi syndrome (PWS). Characterization of the mechanisms that underlie PWS-associated hyperphagia has been slowed by the paucity of animal models with increased food intake or obesity. Mice with a microdeletion encompassing the Snord116 cluster of noncoding RNAs encoded within the Prader-Willi minimal deletion critical region have previously been reported to show growth retardation and hyperphagia. Here, consistent with previous reports, we observed growth retardation in Snord116+/-P mice with a congenital paternal Snord116 deletion...
January 29, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29374067/rnf6-promotes-colorectal-cancer-by-activating-the-wnt-%C3%AE-catenin-pathway-via-ubiquitination-of-tle3
#14
Lei Liu, Yanquan Zhang, Chi Chun Wong, Jingwan Zhang, Yujuan Dong, Xiangchun Li, Wei Kang, Francis Kl Chan, Joseph Jy Sung, Jun Yu
Gene amplification is a hallmark of cancer and is frequently observed in colorectal cancer (CRC). Previous whole-genome sequencing of CRC clinical specimens identified amplification of Ring finger protein 6 (RNF6), a RING-domain E3 ubiquitin ligase. In this study, we show that RNF6 is upregulated in 73.5% (147/200) of CRC patients, and was positively associated with RNF6 gene amplification. Further, RNF6 expression and its gene amplification were independent prognostic factors for poor outcome of CRC patients...
January 26, 2018: Cancer Research
https://www.readbyqxmd.com/read/29374064/forkhead-box-f2-suppresses-gastric-cancer-through-a-novel-foxf2-irf2bpl-%C3%AE-catenin-signaling-axis
#15
Akira Higashimori, Yujuan Dong, Yanquan Zhang, Wei Kang, Geicho Nakatsu, Simon Sm Ng, Tetsuo Arakawa, Joseph Jy Sung, Francis Kl Chan, Jun Yu
DNA methylation has been identified as a hallmark of gastric cancer (GC). Identifying genes that are repressed by DNA promoter methylation is essential in providing insights into the molecular pathogenesis of GC. Using genome-wide methylation studies we identified that transcription factor forkhead box F2 (FOXF2) was preferentially methylated in GC. We then investigated the functional significance and clinical implication of FOXF2 in GC. FOXF2 was silenced in GC cell lines and cancer tissues by promoter methylation, which was negatively associated with mRNA expression...
January 26, 2018: Cancer Research
https://www.readbyqxmd.com/read/29373926/treatment-of-knee-osteoarthritis-with-bone-marrow-derived-mononuclear-cell-injection-12-month-follow-up
#16
Valdis Goncars, Konstantins Kalnberzs, Eriks Jakobsons, Ilze Enģele, Ieva Briede, Kristaps Blums, Kristaps Erglis, Martins Erglis, Liene Patetko, Indrikis Muiznieks, Andrejs Erglis
Objectives To evaluate the main symptoms of knee osteoarthritis (OA) and tissue structure changes after a single dose bone marrow-derived mononuclear cell (BM MNC) intra articular injection. Case series study. Patients with knee OA Kellgren Lawrence (K-L) grade II and III received 1 injection of BM MNC. The clinical results were analyzed with the Knee injury and Osteoarthritis Outcome Score (KOOS) and Knee Society Score (KSS) before, 3, 6, and 12 months after injection. Radiological evaluation was performed with a calibrated x-ray and the magnetic resonance (MR) imaging before and 6 to 7 months postinjection...
January 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29372030/changes-in-expression-of-klotho-affect-physiological-processes-diseases-and-cancer
#17
REVIEW
Nguyen Thi Xuan, Nong Van Hai
Klotho (KL) encodes a single-pass transmembrane protein and is predominantly expressed in the kidney, parathyroid glands, and choroid plexus. Genetic studies on the KL gene have revealed that DNA hypermethylation is one of the major risk factors for aging, diseases, and cancer. Besides, KL exerts anti-inflammatory and anti-tumor effects by regulating signaling pathways and the expression of target genes. KL participates in modulation of the insulin/insulin-like growth factor-1 (IGF-1) signaling, which induces the growth hormone (GH) secretion...
January 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29369174/a-case-report-and-literature-review-on-fabella-syndrome-after-high-tibial-osteotomy
#18
Taehun Kim, Haksun Chung, Hyungmin Lee, Young Choi, Jung-Hwan Son
RATIONALE: The fabella is a normal structure, but is occasionally reported to cause posterior knee pain. The aim of this study was to present fabella syndrome after high tibial osteotomy. PATIENT CONCERNS: A 55-year-old female patient was admitted to the hospital due to about 1 year and 8 months of left knee pain. Sclerosis was observed in the anterior margin of the fabella in the preoperative magnetic resonance (MR) T2 image, and reactive bone marrow was found and was considered to be due to degeneration of the distal femur...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29355090/combining-morphology-and-molecular-data-to-improve-drosophila-paulistorum-diptera-drosophilidae-taxonomic-status
#19
Rebeca Zanini, Mário Josias Müller, Gilberto Cavalheiro Vieira, Victor Hugo Valiati, Maríndia Deprá, Vera Lúcia da Silva Valente
The willistoni species subgroup has been the subject of several studies since the latter half of the past century and is considered a Neotropical model for evolutionary studies, given the many levels of reproductive isolation and different evolutionary stages occurring within them. Here we present for the first time a phylogenetic reconstruction combining morphological characters and molecular data obtained from 8 gene fragments (COI, COII, Cytb, Adh, Ddc, Hb, kl-3 and per). Some relationships were incongruent when comparing morphological and molecular data...
January 22, 2018: Fly
https://www.readbyqxmd.com/read/29341369/structural-factors-affecting-binding-of-platinum-anticancer-agents-with-phospholipids-influence-of-charge-and-phosphate-clamp-formation
#20
Anil Kumar Gorle, Junyong Zhang, Qin Liu, Susan J Berners-Price, Nicholas P Farrell
We report a detailed NMR and DFT study of the interaction of polynuclear platinum anticancer agents (PPCs) with negatively charged phospholipids as a mechanism for their cellular uptake. The reactions of fully 15N-labelled [{trans-PtCl(NH3)2}2(-trans-Pt(NH3)2{NH2(CH2)6NH2}2)]4+ (15N-1, 1,0,1/t,t,t) and the dinuclear [{trans-PtCl(NH3)2}2{-H2N(CH2)6NH2}]2+ (15N-2, 1,1/t,t) with the sodium salt of 1,2-dihexanoyl-sn-glycero-3-phosphate (DHPA) were studied at 298 K, pH ~5.4, by [1H,15N] HSQC 2D NMR spectroscopy...
January 17, 2018: Chemistry: a European Journal
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