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S R Saifuddin, W Devlies, A Santaolalla, F Cahill, G George, D Enting, S Rudman, P Cathcart, B Challacombe, P Dasgupta, C Galustian, A Chandra, S Chowdhury, C Gillett, M Van Hemelrijck
The KHP PCaBB was established in 2013 and recruits donors from the Urology or Oncology Departments at Guy's Hospital in London (UK). Prostate cancer patients may be approached to give their consent for biobanking at any point in their treatment pathway, which allows residual material from their earlier diagnosis to be transferred and used by the Biobank. Currently, patients are specifically asked to donate samples of blood and surplus prostate tissue as well as permitting access to their clinical and pathological data that continues to be added throughout the course of their disease...
November 22, 2017: BMC Cancer
Ahra Jo, Minho Jeon, Heeyoung Oh
OBJECTIVES: This study aimed to determine the prevalence of suicidal ideation among young and middle-aged adults, and explore the risk factors that affect suicidal ideation. METHODS: A descriptive study design was used for secondary data analysis. A total sample of 5,214 was drawn from two waves (2012-2013) of the 7th Korea Health Panel (KHP) survey. The KHP data were collected by a well-trained interviewer using the face-to-face method during home visits as well as self-report method...
June 2017: Osong Public Health and Research Perspectives
Marit Kolb, Müfit Bahadir, Burkhard Teichgräber
Worldwide, the standard methods for the determination of the important wastewater parameter chemical oxygen demand (COD) are still based on the use of the hazardous chemicals, mercury sulfate and chromium(VI). However, due to their properties they are meanwhile classified as "priority pollutants" and shall be phased out or banned in the frame of REACH (current European Chemical Law: Registration, Evaluation, Authorization and restriction of Chemicals) by the European Union. Hence, a new wet-chemical method free of mercury and chromium(VI) was developed...
October 1, 2017: Water Research
R P Oates, Michelle Mcmanus, Seenivasan Subbiah, David M Klein, Robert Kobelski
Internal standards are essential in electrospray ionization liquid chromatography-mass spectrometry (ESI-LC-MS) to correct for systematic error associated with ionization suppression and/or enhancement. A wide array of instrument setups and interfaces has created difficulty in comparing the quantitation of absolute analyte response across laboratories. This communication demonstrates the use of primary standards as operational qualification standards for LC-MS instruments and their comparison with commonly accepted internal standards...
July 14, 2017: Journal of Chromatography. A
Arkke J Eskola, Ivan O Antonov, Leonid Sheps, John D Savee, David L Osborn, Craig A Taatjes
Product formation, in particular ketohydroperoxide formation and decomposition, were investigated in time-resolved, Cl-atom initiated neopentane oxidation experiments in the temperature range 550-675 K using a photoionization time-of-flight mass spectrometer. Ionization light was provided either by Advanced Light Source tunable synchrotron radiation or ∼10.2 eV fixed energy radiation from a H2-discharge lamp. Experiments were performed both at 1-2 atm pressure using a high-pressure reactor and also at ∼9 Torr pressure employing a low-pressure reactor for comparison...
May 31, 2017: Physical Chemistry Chemical Physics: PCCP
Tetsuya Inagaki, Tomoko Watanabe, Satoru Tsuchikawa
Near infrared (NIR) spectroscopy is a common means of non-invasively determining the concentrations of organic compounds in relatively transparent aqueous solutions. Rigorous determination for limit of detection (LOD) is of importance for the application use of NIR spectroscopy. The work reported herein determined the LOD with the analysis of potassium hydrogen phthalate (KHP) in water with partial least square (PLS) calibration in the range of 6300-5800 cm-1 between the two strong absorption bands of water, in which the C-H overtone bands of KHP are located...
2017: PloS One
Ya-An Lin, Shiuh-Jen Jiang, A C Sahayam
A method was developed by coupling ion chromatography (IC) and inductively coupled plasma mass spectrometry (ICP-MS) for the speciation of antimony. In this study, antimony species such as antimonite [Sb(III)], antimonate [Sb(V)] and trimethyl antimony(V) (TMeSb) were separated in less than 8min using anion exchange chromatography with a Hamilton PRP-X100 column as the stationary phase. Mobile phase A was 20mmolL(-1) ethylenediaminetetraacetic acid (EDTA), 2mmolL(-1) potassium hydrogen phthalate (KHP) in 1% v/v methanol (pH 5...
September 1, 2017: Food Chemistry
Honghan Wu, Anika Oellrich, Christine Girges, Bernard de Bono, Tim J P Hubbard, Richard J B Dobson
Neurodegenerative disorders such as Parkinson's and Alzheimer's disease are devastating and costly illnesses, a source of major global burden. In order to provide successful interventions for patients and reduce costs, both causes and pathological processes need to be understood. The ApiNATOMY project aims to contribute to our understanding of neurodegenerative disorders by manually curating and abstracting data from the vast body of literature amassed on these illnesses. As curation is labour-intensive, we aimed to speed up the process by automatically highlighting those parts of the PDF document of primary importance to the curator...
January 1, 2017: Database: the Journal of Biological Databases and Curation
Dilys Haner, Debra Pepler
OBJECTIVE: Young people in Canada prefer to use the Internet over face-to-face contact when seeking help for problems of daily living and mental health problems. Kids Help Phone (KHP) provides on-demand, anonymous help to young people via telephone and Live Chat technologies. METHODS: Two hundred thirty-two phone clients and 230 Live Chat clients responded to a questionnaire at this otherwise anonymous service, providing previously inaccessible data about their individual characteristics and characterizations of the problems for which they sought help...
2016: Journal of the Canadian Academy of Child and Adolescent Psychiatry
Shaukat Ali M Shaikh, Atanu Barik, Beena G Singh, Ramani V Modukuri, Neduri V Balaji, Gottumukkala V Subbaraju, Devidas B Naik, K Indira Priyadarsini
Hispolon (HS), a natural polyphenol found in medicinal mushrooms, and its isoxazole (HI) and pyrazole (HP) derivatives have been examined for free radical reactions and in vitro antioxidant activity. Reaction of these compounds with one-electron oxidant, azide radicals ([Formula: see text]) and trichloromethyl peroxyl radicals ([Formula: see text]), model peroxyl radicals, studied by nanosecond pulse radiolysis technique, indicated formation of phenoxyl radicals absorbing at 420 nm with half life of few hundred microseconds (μs)...
December 2016: Free Radical Research
Adam Michael Scheer, Arkke J Eskola, David L Osborn, Leonid Sheps, Craig Allen Taatjes
The pulsed photolytic chlorine-initiated oxidation of diethyl ketone [DEK; (CH3CH2)2C=O], 2,2,4,4-d4-DEK [d4-DEK; (CH3CD2)2C=O] and 1,1,1,5,5,5-d6-DEK [d6-DEK; (CD3CH2)2C=O] is studied at 8 Torr and 1 - 2 atm and from 400 - 625 K. Cl atoms produced by laser photolysis react with diethyl ketone to form either primary (3-pentan-on-1-yl, RP) or secondary (3-pentan-on-2-yl, RS¬¬) radicals, which in turn react with O2. Multiplexed time of flight mass spectrometry, coupled to either a hydrogen discharge lamp or tunable synchrotron photoionizing radiation, is used to detect products as a function of mass, time and photon energy...
October 11, 2016: Journal of Physical Chemistry. A
Jin-Won Noh, Kyoung-Beom Kim, Hyunchun Park, Young Dae Kwon
BACKGROUND: This study aims to set itself apart from prior research by elucidating gender differences in outpatient service utilization among adults aged 20 years or older, using nationally representative survey data. METHODS: Data from the Korea Health Panel (KHP) collected between 2010 and 2011 were used. In this study, all KHP participants who accessed outpatient service between 2010 and 2011 were included; 13,525 participants used outpatient services in 2010 and 12,991 in 2011...
February 2017: Journal of Women's Health
Yong Zhang, Peng Zhao, Jie Li, Deyin Hou, Jun Wang, Huijuan Liu
A novel catalytic ozonation membrane reactor (COMR) coupling homogeneous catalytic ozonation and direct contact membrane distillation (DCMD) was developed for refractory saline organic pollutant treatment from wastewater. An ozonation process took place in the reactor to degrade organic pollutants, whilst the DCMD process was used to recover ionic catalysts and produce clean water. It was found that 98.6% total organic carbon (TOC) and almost 100% salt were removed and almost 100% metal ion catalyst was recovered...
October 2016: Chemosphere
Sojung Park, BoRin Kim, Soojung Kim
This study examined relationships between socioeconomic disadvantage and unmet health care needs among older adults in Korea adjusting for predisposing and health need factors. We examined how older adults' low-income status and working status affect unmet needs for healthcare over time, and how the association varies by reason for unmet needs (i.e. financial or non-financial). We used three waves of data (2009, 2011, 2012) from the Korea Health Panel (KHP) survey and a multinomial logistic mixed model to analyze how low socioeconomic disadvantages affects changes in unmet healthcare needs independently and in combination...
June 2016: Health Policy
Jeong-Eun Lee, Hyung-Ik Shin, Young Kyung Do, Eun Joo Yang
Persons with disabilities use more health care services due to ill health and face higher health care expenses and burden. This study explored the incidence of catastrophic health expenditures of households with persons with disabilities compared to that of those without such persons. We used the Korean Health Panel (KHP) dataset for the years 2010 and 2011. The final sample was 5,610 households; 800 (14.3%) of these were households with a person with a disability and 4,810 (85.7%) were households without such a person...
March 2016: Journal of Korean Medical Science
Dennis Ausiello, Scott Lipnick
The next frontier in medicine involves better quantifying human traits, known as "phenotypes." Biological markers have been directly associated with disease risks, but poor measurement of behaviors such as diet and exercise limits our understanding of preventive measures. By joining together an uncommonly wide range of disciplines and expertise, the Kavli HUMAN Project will advance measurement of behavioral phenotypes, as well as environmental factors that impact behavior. By following the same individuals over time, KHP will liberate new understanding of dynamic links between behavioral phenotypes, disease, and the broader environment...
September 1, 2015: Big Data
Laura Bierut, David Cesarini
Despite clear links between genes and smoking, effective public policy requires far richer measurement of the feedback between biological, behavioral, and environmental factors. The Kavli HUMAN Project (KHP) plans to exploit the plummeting costs of data gathering and to make creative use of new technologies to construct a longitudinal panel data set that would compare favorably to existing longitudinal surveys, both in terms of the richness of the behavioral measures and the cost-effectiveness of the data collection...
September 1, 2015: Big Data
Adam Drewnowski, Ichiro Kawachi
Health is shaped by both personal choices and features of the food environment. Food-choice decisions depend on complex interactions between biology and behavior, and are further modulated by the built environment and community structure. That lower-income families have lower-quality diets is well established. Yet, diet quality also varies across small geographic neighborhoods and can be influenced by transportation, retail, and ease of access to healthy foods, as well as by attitudes, beliefs, and social interactions...
September 1, 2015: Big Data
Kenneth M Langa, David Cutler
The Kavli HUMAN Project (KHP) will provide groundbreaking insights into how biological, medical, and social factors interact and impact the risks for cognitive decline from birth through older age. It will richly measure the effect of cognitive decline on the ability to perform key activities of daily living. In addition, due to its family focus, the KHP will measure the impact on family members, including the amount of time that family members spend providing care to older adults with dementia. It will also clarify the division of caregiving duties among family members and the effects on caregivers' work, family life, and balance thereof...
September 1, 2015: Big Data
Okan Azmak, Hannah Bayer, Andrew Caplin, Miyoung Chun, Paul Glimcher, Steven Koonin, Aristides Patrinos
Until now, most large-scale studies of humans have either focused on very specific domains of inquiry or have relied on between-subjects approaches. While these previous studies have been invaluable for revealing important biological factors in cardiac health or social factors in retirement choices, no single repository contains anything like a complete record of the health, education, genetics, environmental, and lifestyle profiles of a large group of individuals at the within-subject level. This seems critical today because emerging evidence about the dynamic interplay between biology, behavior, and the environment point to a pressing need for just the kind of large-scale, long-term synoptic dataset that does not yet exist at the within-subject level...
September 1, 2015: Big Data
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