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M Kajaia, M Butsashvili, L Gulbiani, Kh Khatiashvili, K Mindeli, N Osepaishvili, K Gordeladze, A Kobaek, G Kamkamidze
In 2014-2016, the Georgia Red Cross Society (GRCS) implemented a project to improve diabetes prevention, detection and care in rural Georgia, namely in the Gardabani district. The KAP survey was conducted to determine current levels of knowledge, attitudes and practices regarding diabetes among the general population in the Gardabani district. We compared current findings with baseline results from a 2014 survey to identify trends. A cross sectional study design with multi-stage random sampling was used to select participants...
September 2016: Georgian Medical News
M Kochlamazashvili, Kh Khatiashvili, M Butsashvili, O Chubinishvili, Sh Khetsuriani, G Kamkamidze
In Georgia, causative agents among infants with systemic infections are generally not identified and "neonatal sepsis" is usually diagnosed and treated without determining the etiology. The objective of this study was to estimate the role of viral pathogens (Herpesviridae and Enteroviruses) among neonates with generalized infections. A cross-sectional study was performed among neonates younger than <8 weeks admitted to a neonatal intensive care unit (NICU) at the two largest pediatric hospitals in Tbilisi, Georgia...
September 2016: Georgian Medical News
Anelya Kh Alieva, Elena V Filatova, Anna A Kolacheva, Margarita M Rudenok, Petr A Slominsky, Mikhail V Ugrumov, Maria I Shadrina
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Despite progress in the study of the molecular, genetic, and pathogenic mechanisms of PD, it is unclear which processes trigger the development of the pathology associated with PD. Models of the presymptomatic and early symptomatic stages of PD induced by MPTP have been used to analyze changes in transcriptome profile in brain tissues, to identify specific patterns and mechanisms underlying neurodegeneration in PD. The whole-transcriptome analysis in the brain tissues of the mice with MPTP-induced PD showed that striatum is involved in the pathogenesis in the earliest stages and the processes associated with vesicular transport may be altered...
October 18, 2016: Molecular Neurobiology
Rabi Chhantyal-Pun, Oliver Welz, John David Savee, Arkke J Eskola, Edmond P F Lee, Lucy Blacker, Henry R Hill, Matilda Ashcroft, M Anwar H H Khan, Guy C Lloyd-Jones, Louise A Evans, Brandon Rotavera, Haifeng Huang, David L Osborn, Daniel K W Mok, John M Dyke, Dudley E Shallcross, Carl John Percival, Andrew J Orr-Ewing, Craig Allen Taatjes
The Criegee intermediate acetone oxide, (CH3)2COO, is formed by laser photolysis of 2,2-diiodopropane in the presence of O2 and characterized by synchrotron photoionization mass spectrometry and by cavity ringdown ultraviolet absorption spectroscopy. The rate coefficient of the reaction of the Criegee intermediate with SO2 was measured using photoionization mass spectrometry and pseudo-first order methods to be (7.3 ± 0.5) × 10 11 cm3 s 1 at 298 K and 4 Torr and (1.5 ± 0.5) × 10 10 cm3 s 1 at 298 K and 10 Torr (He buffer)...
October 18, 2016: Journal of Physical Chemistry. A
Antonio Santoru, Claudio Pistidda, Magnus H Sørby, Michele R Chierotti, Sebastiano Garroni, Eugenio Pinatel, Fahim Karimi, Hujun Cao, Nils Bergemann, Thi T Le, Julián Puszkiel, Roberto Gobetto, Marcello Baricco, Bjørn C Hauback, Thomas Klassen, Martin Dornheim
We report for the first time the formation of a metal amide-hydride solid solution. The dissolution of KH into KNH2 leads to an anionic substitution, which decreases the interaction among NH2(-) ions. The rotational properties of the high temperature polymorphs of KNH2 are thereby retained down to room temperature.
September 27, 2016: Chemical Communications: Chem Comm
Youhan Lee, Roberta Poloni, Jihan Kim
We propose a novel biased Widom insertion method that can efficiently compute the Henry coefficient, KH , of gas molecules inside porous materials exhibiting strong adsorption sites by employing purely DFT calculations. This is achieved by partitioning the simulation volume into strongly and weakly adsorbing regions and selectively biasing the Widom insertion moves into the former region. We show that only few thousands of single point energy calculations are necessary to achieve accurate statistics compared to many hundreds of thousands or millions of such calculations in conventional random insertions...
October 8, 2016: Journal of Computational Chemistry
Tarun Bhatnagar, Tapati Dutta, John Stover, Sheela Godbole, Damodar Sahu, Kangusamy Boopathi, Shilpa Bembalkar, Kh Jitenkumar Singh, Rajat Goyal, Arvind Pandey, Sanjay M Mehendale
Models are designed to provide evidence for strategic program planning by examining the impact of different interventions on projected HIV incidence. We employed the Goals Model to fit the HIV epidemic curves in Andhra Pradesh, Maharashtra and Tamil Nadu states of India where HIV epidemic is considered to have matured and in a declining phase. Input data in the Goals Model consisted of demographic, epidemiological, transmission-related and risk group wise behavioral parameters. The HIV prevalence curves generated in the Goals Model for each risk group in the three states were compared with the epidemic curves generated by the Estimation and Projection Package (EPP) that the national program is routinely using...
2016: PloS One
G A Slashcheva, V A Rykov, A V Lobanov, A N Murashev, Yu A Kim, T V Arutyunyan, A F Korystova, L N Kublik, M Kh Levitman, V V Shaposhnikona, Yu N Korystov
We analyzed changes in angiotensin-converting enzyme activity in the aorta of hypertensive SHR rats against the background of age-related BP increase (from week 7 to 14) and the effect of dihydroquercetin on BP rise and angiotensin-converting enzyme activity. Normotensive WKY rats of the same age were used as the control. BP and activity of angiotensin-converting enzyme in the aorta of SHR rats increased with age. Dihydroquercetin in doses of 100 and 300 μg/kg per day had no effect on the increase of these parameters; dihydroquercetin administered to 14-week-old WKY rats in a dose of 300 μg/kg reduced activity of the angiotensin-converting enzyme...
September 2016: Bulletin of Experimental Biology and Medicine
Xiaochen Cai, Subhojit Majumdar, George C Fortman, Anjaneyulu Koppaka, Leonardo Serafim, Burjor Captain, Manuel Temprado, Carl D Hoff
The kinetics of the reaction of Ph3SnH with excess •Cr(CO)3C5Me5 = •Cr, producing HCr and Ph3Sn-Cr, was studied in toluene solution under 2-3 atm CO pressure in the temperature range of 17-43.5 °C. It was found to obey the rate equation d[Ph3Sn-Cr]/dt = k[Ph3SnH][•Cr] and exhibit a normal kinetic isotope effect (kH/kD = 1.12 ± 0.04). Variable-temperature studies yielded ΔH(‡) = 15.7 ± 1.5 kcal/mol and ΔS(‡) = -11 ± 5 cal/(mol·K) for the reaction. These data are interpreted in terms of a two-step mechanism involving a thermodynamically uphill hydrogen atom transfer (HAT) producing Ph3Sn• and HCr, followed by rapid trapping of Ph3Sn• by excess •Cr to produce Ph3Sn-Cr...
October 5, 2016: Inorganic Chemistry
Erieta Nikolikj Dimitrova, Ivana Božinovikj, Simona Ristovska, Aleksandra Hadzieva Pejcikj, Aleksandra Kolevska, Mirjeta Hasani
BACKGROUND: Charcot-Marie-Tooth (CMT) disease is a hereditary disease with signs of chronic non-progressive motor-sensory neuropathy which is characterised by symmetric muscle atrophy and weakness of the distal portion of lower extremities. AIM: The aim is to present two cases with peroneal muscular atrophy, applied rehabilitation procedures and rehabilitation outcome. MATERIAL AND METHODS: Patient DR, aged 51, and patient KH, aged 78. Both patients had weakness and pronounced atrophy of the distal portion of lower extremities, numbness down the legs, contractures in the ankles and walking difficulties...
September 15, 2016: Open Access Macedonian Journal of Medical Sciences
Carlos Kh Wong, W C Yu
BACKGROUND: This study aimed to determine the associations of various sociodemographic factors with the level of disease-specific knowledge among Hong Kong Chinese patients with COPD. METHODS: A cross-sectional survey of 100 Chinese adults with COPD recruited from outpatient clinics was conducted from September 2009 to September 2010. Data on the knowledge specific to COPD and patients' sociodemographics were collected from face-to-face interviews. Primary outcome of disease-specific knowledge was measured using 65-item Bristol COPD Knowledge Questionnaire (BCKQ), summing up the 65 items as the BCKQ overall score...
2016: International Journal of Chronic Obstructive Pulmonary Disease
Naomi Li, Chau Tuan-Anh Ngo, Olga Aleynikova, Nicole Beauchemin, Stéphane Richard
The expression and activities of RNA binding proteins are frequently dysregulated in human cancer. Their roles, however, appears to be complex, with reports indicating both pro-tumorigenic and tumor suppressive functions. Here we show, using two classical mouse cancer models, that the role of KH-type RNA binding protein, Sam68, in tumor development can be influenced by the status of the p53 tumor suppressor. We demonstrate that in mice expressing wild type p53, Sam68-deficiency resulted in a higher incidence and malignancy of carcinogen-induced tumors, suggesting a tumor suppressive role for Sam68...
September 28, 2016: Oncotarget
Regina A Baglia, Courtney M Krest, Tzuhsiung Yang, Pannee Leeladee, David P Goldberg
The addition of Lewis or Brönsted acids (LA = Zn(OTf)2, B(C6F5)3, HBAr(F), TFA) to the high-valent manganese-oxo complex Mn(V)(O)(TBP8Cz) results in the stabilization of a valence tautomer Mn(IV)(O-LA)(TBP8Cz(•+)). The Zn(II) and B(C6F5)3 complexes were characterized by manganese K-edge X-ray absorption spectroscopy (XAS). The position of the edge energies and the intensities of the pre-edge (1s to 3d) peaks confirm that the Mn ion is in the +4 oxidation state. Fitting of the extended X-ray absorption fine structure (EXAFS) region reveals 4 N/O ligands at Mn-Nave = 1...
October 17, 2016: Inorganic Chemistry
Kh Pohranychna
AIM: To study a rare clinical case of isolated primary osteoma localized in the frontal bone, provide its detailed clinical and pathomorphological analysis, and evaluate statistical indicators of occurrence frequency and localization of facial skeleton osteomas during 2006-2015. MATERIALS AND METHODS: The retrospective case records analysis of patients undergoing treatment in the ma-xillofacial department of Lviv Regional Clinical Hospital and suffering from facial skeleton osteomas was conducted...
September 2016: Experimental Oncology
Jessie L Leung, Patrick Hy Chung, Paul Kh Tam, Kenneth Ky Wong
BACKGROUND: Rectal prolapse has been reported after laparoscopic assisted anorectal pullthrough in children with anorectal malformation. We report our clinical outcome and study the application of an anchoring stitch to tack the rectum to the presacral fascia and the occurrence of rectal prolapse. MATERIAL AND METHODS: A retrospective review of all children who had undergone laparoscopic assisted anorectal pullthrough for anorectal malformation from 2000 to 2015 was performed...
September 17, 2016: Journal of Pediatric Surgery
Kh Rezaee, E Azizi, J Haddadnia
BACKGROUND: Epilepsy is a severe disorder of the central nervous system that predisposes the person to recurrent seizures. Fifty million people worldwide suffer from epilepsy; after Alzheimer's and stroke, it is the third widespread nervous disorder. OBJECTIVE: In this paper, an algorithm to detect the onset of epileptic seizures based on the analysis of brain electrical signals (EEG) has been proposed. 844 hours of EEG were recorded form 23 pediatric patients consecutively with 163 occurrences of seizures...
June 2016: Journal of Biomedical Physics & Engineering
Eugene Ct Lau, Adrian Ch Fung, Kenneth Ky Wong, Paul Kh Tam
BACKGROUND: Necrotizing enterocolitis in premature neonates often results in bowel resection and stoma formation. One way to promote bowel adaptation before stoma closure is to introduce proximal loop effluents into the mucous fistula. In this study, we reviewed our experience with distal loop refeeding with respect to control group. METHODS: All patients with necrotizing enterocolitis between 2000 and 2014 necessitating initial diverting enterostomies and subsequent stoma closure in a tertiary referral center were included...
September 15, 2016: Journal of Pediatric Surgery
Kh Safaei, G R Ghorbani, M Alikhani, A Sadeghi-Sefidmazgi, W Z Yang
This study was conducted to investigate the effects of processing method (grinding vs. steam flaking) and increasing densities of steam-flaked barley grain on dry matter intake (DMI), rumen pH and fermentation characteristics, digestibility of dry matter in the total digestive tract (DDTT), and milk production of dairy cows. Eight multiparous mid-lactation Holstein cows averaging 103 ± 24 DIM, 44.5 ± 4.7 kg milk/day and weighing 611 ± 43 kg at the start of the experiment were used in a replicated 4 × 4 Latin square design with 21-day periods...
September 25, 2016: Journal of Animal Physiology and Animal Nutrition
Carol Wy Wong, Shuguang Jin, Jie Chen, Paul Kh Tam, Kenneth Ky Wong
BACKGROUND: Intussusception may require bowel resection. Here, we aim to define factors that predict the need of bowel resection and the presence of pathological lead point. METHODS: A retrospective review was taken from three tertiary centers for all operated intussusception patients from January 2010 to December 2014. Patient demographics were recorded. Statistical analysis was performed, and risk factors were derived by binary logistic regression. RESULTS: Five thousand ninety-six patients were treated for intussusception with 73 (57 male, 16 female) operated...
September 16, 2016: Journal of Pediatric Surgery
Eugeny P Lukashev, Petr P Knox, Vladimir V Gorokhov, Nadezda P Grishanova, Nuranija Kh Seifullina, Maria Krikunova, Heiko Lokstein, Vladimir Z Paschenko
Quantum dots (QDs) absorb ultraviolet and long-wavelength visible light energy much more efficiently than natural bacterial light-harvesting proteins and can transfer the excitation energy to photosynthetic reaction centers (RCs). Inclusion of RCs combined with QDs as antennae into liposomes opens new opportunities for using such hybrid systems as a basis for artificial energy-transforming devices that potentially can operate with greater efficiency and stability than devices based only on biological components or inorganic components alone...
September 12, 2016: Journal of Photochemistry and Photobiology. B, Biology
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