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https://www.readbyqxmd.com/read/28106388/mechanistic-studies-of-single-step-styrene-production-using-a-rhodium-i-catalyst
#1
Benjamin A Vaughan, Sarah K Khani, J Brannon Gary, James D Kammert, Michael S Webster-Gardiner, Bradley A McKeown, Robert J Davis, Thomas R Cundari, T Brent Gunnoe
The direct and single-step conversion of benzene, ethylene, and a Cu(II) oxidant to styrene using the Rh(I) catalyst ((Fl)DAB)Rh(TFA)(η(2)-C2H4) [(Fl)DAB = N,N'-bis(pentafluorophenyl)-2,3-dimethyl-1,4-diaza-1,3-butadiene; TFA = trifluoroacetate] has been reported to give quantitative yields (with Cu(II) as the limiting reagent) and selectivity combined with turnover numbers >800. This report details mechanistic studies of this catalytic process using a combined experimental and computational approach. Examining catalysis with the complex ((Fl)DAB)Rh(OAc)(η(2)-C2H4) shows that the reaction rate has a dependence on catalyst concentration between first- and half-order that varies with both temperature and ethylene concentration, a first-order dependence on ethylene concentration with saturation at higher concentrations of ethylene, and a zero-order dependence on the concentration of Cu(II) oxidant...
January 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28103909/potential-diagnostic-biomarkers-for-chronic-kidney-disease-of-unknown-etiology-ckdu-in-sri-lanka-a-pilot-study
#2
Saravanabavan Sayanthooran, Dhammika N Magana-Arachchi, Lishanthe Gunerathne, Tilak Abeysekera
BACKGROUND: In Sri Lanka, there exists chronic kidney disease of both known (CKD) and unknown etiologies (CKDu). Identification of novel biomarkers that are customized to the specific causative factors would lead to early diagnosis and clearer prognosis of the diseases. This study aimed to find genetic biomarkers in blood to distinguish and identify CKDu from CKD as well as healthy populations from CKDu endemic and non-endemic areas of Sri Lanka. METHODS: The expression patterns of a selected panel of 12 potential genetic biomarkers were analyzed in blood using RT-qPCR...
January 19, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28095951/simulated-microgravity-effects-on-nonsmall-cell-lung-cancer-cell-proliferation-and-migration
#3
Jae Ho Chung, Chi Bum Ahn, Kuk Hui Son, Eunjue Yi, Ho Sung Son, Han-Sung Kim, Sung Ho Lee
BACKGROUND: Despite improvements in medical technology, lung cancer metastasis remains a global health problem. The effects of microgravity on cell morphology, structure, functions, and their mechanisms have been widely studied; however, the biological effects of simulated microgravity on the interaction between cells and its eventual influence on the characteristics of cancer cells are yet to be discovered. We examined the effects of simulated microgravity on the metastatic ability of different lung cancer cells using a random positioning machine...
February 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28094375/crystallization-kinetics-of-cerium-oxide-nanoparticles-formed-by-spontaneous-room-temperature-hydrolysis-of-cerium-iv-ammonium-nitrate-in-light-and-heavy-water
#4
Natasha W Pettinger, Robert E A Williams, Jinquan Chen, Bern Kohler
A stable sol of cerium oxide nanoparticles forms spontaneously when cerium(iv) ammonium nitrate (CAN) is dissolved in room-temperature water at mM concentrations. Electron microscopy experiments reveal the formation of highly crystalline cerium oxide particles several nm in diameter and suggest that they are formed from amorphous particles that are similar in size. Under the low pH conditions of the experiments, the nanoparticles form a stable dispersion and show no evidence of aggregation, even many months after synthesis...
January 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28091928/effects-of-no-synthase-blocker-l-name-on-functional-state-of-the-neuromotor-system-during-traumatic-disease-of-the-spinal-cord
#5
G G Yafarova, V V Andrianov, R Kh Yagudin, I I Shaikhytdinov, Kh L Gainutdinov
Functional state of the neuromotor system after administration of a nonspecific NO synthase blocker L-NAME was studied on the model of experimental contusion of the spinal cord. Electron paramagnetic resonance measurements of NO production in the damaged segment of the spinal cord were performed for estimation of the dynamics of intensity of NO production during traumatic disease of the spinal cord and selection of optimal period for L-NAME administration. The status of the neuromotor system was evaluated by stimulation electromyography...
January 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28074742/development-and-validation-of-an-rp-hplc-method-for-the-determination-of-vinpocetine-and-folic-acid-in-the-presence-of-a-vinpocetine-alkaline-degradation-product-in-bulk-and-in-capsule-form
#6
Ehab F Elkady, Marwa H Tammam, Ayman A Mohamed
An alkaline-forced degradation hydrolytic product of vinpocetine was prepared and characterized by <sup>1</sup>H-NMR, FTIR spectroscopy, and MS. Subsequently, a simple, selective, and validated reversed-phase HPLC method was developed for the simultaneous estimation of vinpocetine and folic acid in the presence of a vinpocetine alkaline degradation product. Chromatographic separation was achieved using an isocratic mobile phase consisting of acetonitrile-0.02 M KH<sub>2</sub>PO<sub>4</sub> [containing 0...
January 11, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28064314/-gene-pool-of-siberian-tatars-five-ways-of-origin-for-five-subethnic-groups
#7
A T Agdzhoyan, E V Balanovska, A D Padyukova, D O Dolinina, M A Kuznetsova, V V Zaporozhchenko, R A Skhalyakho, S M Koshel, M K Zhabagin, Y M Yusupov, Kh Kh Mustafin, M V Ulyanova, Z A Tychinskih, M B Lavryashina, O P Balanovsky
Siberian Tatars form the largest Turkic-speaking ethnic group in Western Siberia. The group has a complex hierarchical system of ethnographically diverse populations. Five subethnic groups of Tobol-Irtysh Siberian Tatars (N = 388 samples) have been analyzed for 50 informative Y-chromosomal SNPs. The subethnic groups have been found to be extremely genetically diverse (FST = 21%), so the Siberian Tatars form one of the strongly differentiated ethnic gene pools in Siberia and Central Asia. Every method employed in our studies indicates that different subethnic groups formed in different ways...
November 2016: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28052668/isolating-the-effects-of-the-proton-tunneling-distance-on-proton-coupled-electron-transfer-in-a-series-of-homologous-tyrosine-base-model-compounds
#8
Starla D Glover, Giovanny A Parada, Todd F Markle, Sascha Ott, Leif Hammarström
The distance dependence of concerted proton-coupled electron transfer (PCET) reactions was probed in a series of three new compounds, where a phenol is covalently bridged by a 5, 6, or 7 membered carbocycle to the quinoline. The carbocycle bridge enforces the change in distance between the phenol oxygen (proton donor) and quinoline nitrogen (proton acceptor), dO••N, giving rise to values ranging from 2.567 to 2.8487 Å, and resulting in calculated proton tunneling distances, r0, that span 0.719 to 1.244 Å...
January 4, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28044321/combined-effect-of-virus-infection-and-water-stress-on-water-flow-and-water-economy-in-grapevines
#9
Hanan El Aou-Ouad, Alicia Pou, Magdalena Tomàs, Rafael Montero, Miquel Ribas-Carbo, Hipólito Medrano, Josefina Bota
Water limitation is one of the major threats affecting grapevine production. Thus, improving water use efficiency (WUE) is crucial for a sustainable viticulture industry in Mediterranean regions. Under field conditions, water stress is often combined with viral infections since those are present in major grape-growing areas worldwide. Grapevine leafroll-associated virus 3 (GLRaV-3) is one of the most important viruses, affecting grapevines. Indeed, the optimization of water use in a real context of virus infection is an important topic that needs to be understood...
January 3, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28042169/the-problem-of-polypharmacy-in-female-patients-with-overactive-bladders-cross-sectional-study-in-a-specialist-outpatient-department
#10
C S Schneidinger, W Umek, B Böhmdorfer
Background: The consumption of certain drugs can cause urinary incontinence. The aim of this study is to determine the frequency of consumption of drugs that can favour incontinence, the incidence of polypharmacy and the incidence of potentially dangerous drug-drug interactions in female patients suffering from overactive bladder (OAB) who presented to a urogynaecological outpatient department. Methods: We undertook a retrospective case series study. The data from 100 female patients who attended the urogynaecological outpatient department of the Vienna General Hospital [VGH; Allgemeinen Krankenhauses Wien (AKH)] in the period from 20...
December 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28008903/-thoracic-echinococcosis-complicated-by-arrosive-bleeding-from-great-vessels
#11
Sh N Khudaibergenov, Kh K Abrolov, R A Ibadov, O T Irisov, O D Eshonkhodzhaev, N T Tursunov, M M Mirolimov, B B Amanov, A T Mustafaev
No abstract text is available yet for this article.
2016: Khirurgiia
https://www.readbyqxmd.com/read/28005034/-treatment-for-acute-respiratory-viral-infection-and-influenza-in-daily-clinical-practice-results-of-the-multicenter-international-observational-flu-ee-study
#12
V Kh Fazylov, I G Sitnikov, E V Silina, S B Shevchenko, L N Mozhina, L L Zamyatina, G A Eganyan, L G Groppa, B M Korsantiya
PURPOSE: To study the clinical aspects of influenza and acute respiratory viral infection (ARVI) in routine clinical practice, with efficacy and safety of the antiviral therapy evaluation. SUBJECTS AND METHODS: In the large multicenter prospective observational study were enrolled 18,946 patients aged 18 to 93 years with previously determined diagnosis of influenza or ARVI from 262 outpatient sites in Russia, Armenia, Moldova and Georgia. According to study design, 3 visits were evaluated...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27982596/fullerene-as-photocatalyst-visible-light-induced-reaction-of-perfluorinated-%C3%AE-%C3%AF-diiodoalkanes-with-c60
#13
Andrey Kh Vorobiev, Ruslan R Gazizov, Andrey Ya Borschevskii, Vitaliy Yu Markov, Vitaliy A Ioutsi, Victor A Brotsman, Lev N Sidorov
Solution phase photochemical reaction of fullerene with perfluorinated alkyldiiodides I-RF-I can be efficiently initiated by visible range irradiation that targets solely the fullerene component. Photoinduced electron transfer from fullerene onto the diiodide component effects dissociative formation of alkyl radicals RFI(•) subsequently consumed by C60 to give the principal detectable radical intermediate C60RFI(•). Experimentally established second-order kinetics with respect to the fullerene concentration evidence that fullerene plays its two roles of photocatalyst and reactant in a decoupled fashion, which suggests its catalytic ability to be of potential use in more complex photochemical systems...
January 3, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27979707/disrupting-domain-domain-interactions-is-indispensable-for-enga-ribosome-interactions
#14
Soneya Majumdar, Abhishek Acharya, Sushil Kumar Tomar, Balaji Prakash
EngA consists of two tandem GTPase-domains-GD1 and GD2-followed by a KH-domain. EngA was considered to be a 50S assembly factor since it was shown to bind 50S and its deletion leads to the accumulation of immature 45S ribosomal subunits. Subsequently, we demonstrated an additional ribosome bound state of EngA bound to 50S, 30S, and 70S. While the former (50S binding) is achieved upon GTP binding at both GD1 and GD2, the latter is formed upon GTP hydrolysis at GD1, which is believed to trigger a large conformational change in the protein...
December 13, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27973513/cascaded-third-harmonic-generation-with-one-kdp-crystal
#15
Hongwei Qi, Zhengping Wang, Fapeng Yu, Xun Sun, Xinguang Xu, Xian Zhao
For KH<sub>2</sub>PO<sub>4</sub> (KDP) crystal, the phase-matching directions of type-II second-harmonic generation (SHG) and type-II third-harmonic generation (THG) for 1 μm lasers are almost identical, i.e., at (θ=60°, φ=0°) around. Utilizing this special property, we designed a THG converter based on one KDP crystal. A quarter-wave (λ/4) plate was used to adjust the polarization of the SHG wave, and a round-trip optical path was used to realize the SHG and THG procedures successively...
December 15, 2016: Optics Letters
https://www.readbyqxmd.com/read/27965085/the-interaction-of-a-trypanosoma-brucei-kh-domain-protein-with-a-ribonuclease-is-implicated-in-ribosome-processing
#16
Smriti Kala, Vaibhav Mehta, Chun Wai Yip, Houtan Moshiri, Hamed Shateri Najafabadi, Ruoyu Ma, Najmeh Nikpour, Sara L Zimmer, Reza Salavati
Ribosomal RNA maturation is best understood in yeast. While substantial efforts have been made to explore parts of these essential pathways in animals, the similarities and uniquenesses of rRNA maturation factors in non-Opisthokonts remain largely unexplored. Eukaryotic ribosome synthesis requires the coordinated activities of hundreds of Assembly Factors (AFs) that transiently associate with pre-ribosomes, many of which are essential. Pno1 and Nob1 are two of six AFs that are required for the cytoplasmic maturation of the 20S pre-rRNA to 18S rRNA in yeast where it has been almost exclusively analyzed...
January 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/27957852/mer-fac-and-bidentate-coordination-of-an-alkyl-pop-ligand-in-the-chemistry-of-nonclassical-osmium-hydrides
#17
Miguel A Esteruelas, Cristina García-Yebra, Jaime Martín, Enrique Oñate
Nonclassical and classical osmium polyhydrides containing the diphosphine 9,9-dimethyl-4,5-bis(diisopropylphosphino)xanthene (xant(P(i)Pr2)2), coordinated in κ(3)-mer, κ(3)-fac, and κ(2)-P,P fashions, have been isolated during the cyclic formation of H2 by means of the sequential addition of H(+) and H(-) or H(-) and H(+) to the classical trihydride OsH3Cl{xant(P(i)Pr2)2} (1). This complex adds H(+) to form the compressed dihydride dihydrogen complex [OsCl(H···H)(η(2)-H2){xant(P(i)Pr2)2}](+) (2). Under argon, cation 2 loses H2 and the resulting unsaturated fragment dimerizes to give [(Os(H···H){xant(P(i)Pr2)2})2(μ-Cl)2](2+) (3)...
January 3, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/27957584/evolution-of-laparoscopic-liver-resection-at-singapore-general-hospital-a-nine-year-experience-of-195-consecutive-resections
#18
Brian Kp Goh, Jin-Yao Teo, Chung-Yip Chan, Ser-Yee Lee, Peng-Chung Cheow, Pierce Kh Chow, London Lpj Ooi, Alexander Yf Chung
INTRODUCTION: We aimed to analyse the changing trends, safety and outcomes associated with the adoption of laparoscopic liver resection (LLR) at a single centre. METHODS: A retrospective review was carried out of 195 patients who underwent LLR from 2006 to 2014 at our institution. To explore the evolution of LLR, the study was divided into three equal consecutive time periods (period 1: 2006-2008; period 2: 2009-2011; and period 3: 2012-2014). RESULTS: Among 195 patients who underwent LLR, 24 (12...
December 13, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27941940/kefir-peptides-prevent-high-fructose-corn-syrup-induced-non-alcoholic-fatty-liver-disease-in-a-murine-model-by-modulation-of-inflammation-and-the-jak2-signaling-pathway
#19
H L Chen, T C Tsai, Y C Tsai, J W Liao, C C Yen, C M Chen
OBJECTIVE: In recent years, people have changed their eating habits, and high-fructose-containing bubble tea has become very popular. High-fructose intake has been suggested to be a key factor that induces non-alcoholic fatty liver disease (NAFLD). Kefir, a fermented milk product composed of microbial symbionts, has demonstrated numerous biological activities, including antibacterial, antioxidant and immunostimulating effects. The present study aims to evaluate the effects of kefir peptides on high-fructose-induced hepatic steatosis and the possible molecular mechanism...
December 12, 2016: Nutrition & Diabetes
https://www.readbyqxmd.com/read/27936190/two-isoforms-of-yersinia-pestis-plasminogen-activator-pla-intraspecies-distribution-intrinsic-disorder-propensity-and-contribution-to-virulence
#20
Svetlana V Dentovskaya, Mikhail E Platonov, Tat'yana E Svetoch, Pavel Kh Kopylov, Tat'yana I Kombarova, Sergey A Ivanov, Rima Z Shaikhutdinova, Lyubov' V Kolombet, Sadhana Chauhan, Vitaly G Ablamunits, Vladimir L Motin, Vladimir N Uversky, Andrey P Anisimov
It has been shown previously that several endemic Y. pestis isolates with limited virulence contained the I259 isoform of the outer membrane protease Pla, while the epidemic highly virulent strains possessed only the T259 Pla isoform. Our sequence analysis of the pla gene from 118 Y. pestis subsp. microtus strains revealed that the I259 isoform was present exclusively in the endemic strains providing a convictive evidence of more ancestral origin of this isoform. Analysis of the effects of the I259T polymorphism on the intrinsic disorder propensity of Pla revealed that the I259T mutation slightly increases the intrinsic disorder propensity of the C-terminal tail of Pla and makes this protein slightly more prone for disorder-based protein-protein interactions, suggesting that the T259 Pla could be functionally more active than the I259 Pla...
2016: PloS One
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