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Ramkumar Aishworiya, Po Fun Chan, Jennifer Sh Kiing, Shang Chee Chong, Stacey Kh Tay
INTRODUCTION: This study aimed to determine the sleep patterns and dysfunctions in children with learning problems in comparison against a local population-based sample. MATERIALS AND METHODS: Parents of 200 children with learning problems and 372 parents of a local population-based sample of typically developing (TD) children were recruited to complete a questionnaire on their child's sleep patterns and sleep problems. The Children's Sleep Habits Questionnaire (CSHQ) is a validated parent-reported sleep screening questionnaire that contains 54 items identifying sleep behaviours in children...
November 2016: Annals of the Academy of Medicine, Singapore
Kh Ghanbari, F Ahmadi
A novel sensitive non-enzymatic glucose sensor was fabricated based on nickel oxide hedgehog-like nanostructures decorated ternary gold nanoparticles/polyaniline nanofibers/reduced graphene oxide nanocomposites (NiO/Au/PANI/rGO). The morphology and structure of NiO/Au/PANI/rGO nanocomposites were characterized by field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), Raman spectroscopy, and Fourier transform infrared (FT-IR). Electrochemical impedance spectroscopy (EIS) data also indicated the charge transfer of each layer decreased compared to the underneath layer...
December 1, 2016: Analytical Biochemistry
V Kh Khavinson, N S Lin'kova, S I Tarnovskaya
Short peptides constitute the system of signal molecules regulating the functions of the organism at the molecular, genetic, subcellular, cellular, and tissue levels. One short peptide can regulate dozens of genes, but the molecular mechanism of this process remains unclear. We suppose that short peptides penetrate through the cytoplasmic and nuclear membrane and bind to DNA. Spatial models of DNA-peptide complexes are constructed for 19 short peptides by the docking method. Some peptides have the same binding sites...
December 1, 2016: Bulletin of Experimental Biology and Medicine
Flávia Moraes Silva, Luciane Figueira
OBJECTIVE: The aim of this study was to evaluate the precision of estimated height from ulna length (UL) using the Malnutrition Universal Screening Tool (MUST) equation and compare it with predicted height from knee height (KH), and self-reported height in estimating actual body height in inpatients. METHODS: This cross-sectional study was carried out with patients admitted to an emergency service of a tertiary public hospital. Data were collected, at the patients' bedsides, from a specific questionnaire and anthropometric measurements...
January 2017: Nutrition
O G Deryagin, S A Gavrilova, S V Buravkov, V V Andrianov, G G Yafarova, Kh L Gainutdinov, V B Koshelev
AIM: To study a role of ATP-dependent potassium channels (K+ATP) in the neuroprotective effect of ischemic (IP) and pharmacological (PP) preconditioning and evaluate the dynamics of blood nitric oxide (NO) metabolites in cerebral ischemia. MATERIAL AND METHODS: A model of ischemic stroke induced by the electrocoagulation of a middle cerebral artery (MCA) branch was used in male rats (n=86). Glibenclamide, a selective inhibitor of ATP-sensitive K+ channels, and diazoxide, a potassium channel activator, were used...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Yulia B Dudkina, Kirill V Kholin, Tatyana V Gryaznova, Daut R Islamov, Olga N Kataeva, Ildar Kh Rizvanov, Alina I Levitskaya, Olga D Fominykh, Marina Yu Balakina, Oleg G Sinyashin, Yulia H Budnikova
A series of diverse binuclear and mononuclear cyclometalated palladium(ii) complexes of different structure was investigated by electrochemical techniques combined with density functional theory (DFT) calculations. The studies including cyclic and differential pulse voltammetry, X-ray structure analysis and quantum chemical calculations revealed a regularity of the complexes oxidation potential on the metal-metal distance in the complexes: the larger Pd-Pd distance, the higher oxidation potentials. The reduction potentials feature unusually high negative values while no correlation depending on the structure could be observed...
November 30, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Yu-An Kung, Chuan-Tien Hung, Kun-Yi Chien, Shin-Ru Shih
Cells and viruses can utilize internal ribosome entry sites (IRES) to drive translation when cap-dependent translation is inhibited by stress or viral factors. IRES trans-acting factors (ITAFs) are known to participate in such cap-independent translation, but there are gaps in the understanding as to how ITAFs, particularly negative ITAFs, regulate IRES-driven translation. This study found that Lys109, Lys121 and Lys122 represent critical ubiquitination sites for far upstream element-binding protein 2 (KHSRP, also known as KH-type splicing regulatory protein or FBP2), a negative ITAF...
November 28, 2016: Nucleic Acids Research
Peter Courtney Junk, Daniel Werner, Xuefei Zhao, Stephen Best, Laurent Maron, Glen Deacon
Divalent [Yb(DippForm)2(thf)n] (n = 2 (1a), or 1 (1b); DippForm = N,N'-bis(2,6-diisopropylphenyl)formamidinate) complexes were treated with the ketones: 9-fluorenone (fn), or 2,3,4,5-tetraphenylcyclopentadienone (tpc, tetracyclone), giving ketyl† complexes: [Yb(DippForm)2(fn˙-O)(thf)] (2), and [Yb(DippForm)2(tpc˙-O)] (3) respectively. By contrast, when perfluorobenzophenone (pfb) was treated with either 1a or 1b, transitory ketyl formation was followed by rapid decomposition via a C-F activation pathway, giving [YbF(DippForm)2(thf)] (4a) and a highly unusual fluoride/oxide bridged species: [Yb5F6O2(DippForm)5] (4b)...
November 29, 2016: Chemistry: a European Journal
Ruizhong Zhang, Zefeng Lin, Vincent Ch Lui, Kenneth Ky Wong, Paul Kh Tam, Puiyan Lee, Chun Nam Lok, Jonathan R Lamb, Yan Chen, Huimin Xia
Biliary atresia (BA) is a neonatal biliary system disease closely associated with viral infection and bile duct inflammation. Silver nanoparticles (AgNps) have previously revealed antiviral and anti-inflammatory properties. In this study, we have investigated the effects of AgNps in the treatment of the Rhesus rotavirus inoculation induced BA in mice. The morphology, liver histopathology, clinical biochemistry examination, and inflammatory cells were analyzed in BA mice. Results indicated that AgNps could significantly increase the survival rate of BA mice, and reduce jaundice and weight lost and the liver enzymes and bilirubin metabolism clinical parameters were close to the normal levels...
November 25, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
Aeryun Kim, Stephanie L Servetas, Jieun Kang, Jinmoon Kim, Sungil Jang, Yun Hui Choi, Hanfu Su, Yeong-Eui Jeon, Youngmin A Hong, Yun-Jung Yoo, D Scott Merrell, Jeong-Heon Cha
The array of outer membrane proteins (OMPs) found in Helicobacter pylori provides a crucial component for persistent colonization within the gastric niche. Not only does H. pylori harbor a wide number of OMPs, but these OMPs often vary across strains; this likely contributes to immune evasion, adaptation during long term colonization, and potentially differential disease progression. Previous work from our group described OMP differences among the Bab family (babA, babB, and babC) and Hom family (homA and homB) from 80 American H...
December 2016: Journal of Microbiology / the Microbiological Society of Korea
V M Elinson, L V Didenko, N V Shevlyagina, G A Avtandilov, A Kh Gaidarova, A N Lyamin
Colonization of fluorinated surfaces produced by ion-plasma technology by Staphylococcus aureus was studied by scanning electron microscopy and surface energy analysis. It was shown that the intensity of colonization was determined by the surface relief and fluorine content. Formation of nanostructured surfaces accompanied by a sharp decrease in the surface energy prevented adhesion of Staphylococcus aureus cells to the fluorine-containing surface.
November 23, 2016: Bulletin of Experimental Biology and Medicine
A V Rodina, T Kh Tenchurin, V P Saprykin, A D Shepelev, V G Mamagulashvili, T E Grigor'ev, K I Lukanina, A S Orekhov, E Yu Moskaleva, S N Chvalun
We analyzed viability of mesenchymal stem cells seeded by static and dynamic methods to highly porous fibrous 3D poly-L-lactide scaffolds with similar physical and chemical properties, but different spatial organization modified with collagen. Standard collagen coating promoted protein adsorption on the scaffold surface and improved adhesive properties of 100 μ-thick scaffolds. Modification of 600-μ scaffolds with collagen under pressure increased proliferative activity of mesenchymal stem cells seeded under static and dynamic (delivery of 100,000 cells in 10 ml medium in a perfusion system at a rate of 1 ml/min) conditions by 47 and 648%, respectively (measured after 120-h culturing by MTT test)...
November 23, 2016: Bulletin of Experimental Biology and Medicine
N N Sulaiman, M Ismail
The composite of MgH2/K2NiF6/carbon nanotubes (CNTs) is prepared by ball milling, and its hydrogenation properties are studied for the first time. MgH2 co-catalyzed with K2NiF6 and CNTs exhibited an improvement in the onset dehydrogenation temperature and isothermal de/rehydrogenation kinetics compared with the MgH2-K2NiF6 composite. The onset dehydrogenation temperature of MgH2 doped with 10 wt% K2NiF6 and 5 wt% CNTs is 245 °C, which demonstrated a reduction of 25 °C compared with the MgH2 + 10 wt% K2NiF6 composite...
November 23, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
G A Gadzhimirzaev, A Kh Asiyatilov, Yu A Dzhamaludinov, R G Gadzhimirzaeva, A N Chudinov, M M Atalaev, Kh A Ordashev, G A Asiyatilov, Kh M Magomedova, A K Shakhbanov
This paper presents the currently available data on congenital lateral cysts and fistulas of the neck based on the authors' original experience and the review of the relevant literature. The modern methods for diagnostics and the surgical treatment of these conditions are described and the causes underling the development of their relapses are analyzed. Recommendations for the prevention of congenital cysts and fistulas on the neck are proposed.
2016: Vestnik Otorinolaringologii
R G Gadzhimirzaeva, G A Gadzhimirzaev, E G Gamzatova, Kh M Asadulaeva
The objective of the present study was to formulate the indications for the specific immunotherapy (SIT) of ENT diseases based on the results of the examination and treatment of 1058 patients presenting with allergic rhinitis with special reference to the advantages of this approach over pharmacotherapy. Much attention is given to the adverse reactions associated with the application of immunotherapy and the methods for their correction. Personal opinions of the authors with regard to selected aspects of the use of specific immunotherapy in the otorhionolaryngological practice are presented...
2016: Vestnik Otorinolaringologii
F-D Kopinke, A Georgi, G Imfeld, H-H Richnow
Isotope fractionation between benzene-D0 and benzene-D6 caused by multi-step partitioning of the benzenes between water and two organic solvents, n-octane and 1-octanol, as well as between water and the gas phase, was measured. The obtained fractionation factors αH = KH/KD are αH = 1.080 ± 0.015 and αH = 1.074 ± 0.015 for extraction into n-octane and 1-octanol, respectively, and αH = 1.049 ± 0.010 for evaporation from aqueous solution. The comparison of solvent- and gas-phase partitioning reveals that about 2/3 of the driving force of fractionation is due to different interactions in the aqueous phase, whereas 1/3 is due to different interactions in the organic phase...
November 18, 2016: Chemosphere
E I Chukanova, A S Chukanova, Kh I Mamaeva
There is ample evidence that arterial and venous links of the vascular bed are interrelated, with the venous part, as the highly organized reflexogenic zone, responsible for the development of complex reactions providing the stability of the cerebral blood flow. There is few publications devoted to the venous pathology of the brain however the prevalence of cerebral venous thrombosis (CVT) is relatively high. The annual prevalence of CVT is 4-7 per 1 million of population. Timely recognition and early diagnosis of CVT are most important for successful treatment of patients...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
N Avazashvili, P Imnadze, I Mchedlishvili, Kh Gachechiladze
In this article, there are given data of study for antibiotic sensitivity/resistance of gram-positive and gram-negative representatives of different microbial species, isolated from patients after primary hip replacement and osteosynthesis of long bones, which had post operative infectious complications, and also isolated from samples of traumatology department environment. Identification of sensitivity/resistance to antibiotics was performed with use of two methods - disc diffusion and serial dilution on solid nutrient media...
October 2016: Georgian Medical News
Berrie Meijer, Chris Jj Mulder, Godefridus J Peters, Adriaan A van Bodegraven, Nanne Kh de Boer
AIM: To critically assess the available literature regarding the efficacy of thioguanine treatment in inflammatory bowel disease (IBD) patients, irrespective of the (hepato-) toxicity profile. METHODS: A systematic literature search of the MEDLINE database using PubMed was performed using the keywords "thioguanine", "6-TG", "thioguanine", "inflammatory bowel disease", "IBD", "Crohn's disease", "Ulcerative colitis" and "effectiveness" in order to identify relevant articles published in English starting from 2000...
October 28, 2016: World Journal of Gastroenterology: WJG
S V Kalemenev, O E Zubareva, V V Sizov, V V Lavrent'eva, N Ya Lukomskaya, K Kh Kim, A V Zaitsev, L G Magazanik
The capability of memantine, a noncompetitive antagonist of the NMDA receptors, to prevent impairments of cognitive functions in rats was investigated in the lithium-pilocarpine model of epilepsy. After status epilepticus, rats exhibited impaired exploratory behavior and spatial memory, and a decline of extinction of orienting behavior. Memantine administration prevented these disturbances. Thus, the blockade of the NMDA receptors immediately after status epilepticus allowed prevention of the development of the possible cognitive impairments...
September 2016: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
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