Lene V Halvorsen, Camilla L Søraas, Anne Cecilie K Larstorp, Ulla Hjørnholm, Vibeke N Kjær, Knut Liestøl, Arleen Aune, Eirik Olsen, Karl Marius Brobak, Ola U Bergland, Stine Rognstad, Nikolai R Aarskog, Sondre Heimark, Fadl Elmula M Fadl Elmula, Eva Gerdts, Rune Mo, Marit D Solbu, Mimi S Opdal, Sverre E Kjeldsen, Morten Rostrup, Aud Høieggen
BACKGROUND: Drug concentration in blood or urine is an acknowledged method to detect non-adherence. Observational studies suggest that informing patients about low or absent serum drug levels improves blood pressure (BP). We performed a multicenter randomized clinical trial to test the hypothesis that therapeutic drug monitoring (TDM) could improve drug adherence and BP in patients with uncontrolled hypertension and reduced adherence to antihypertensive drugs. METHODS: Patients were ≥18 years on stable treatment with at least two antihypertensive agents...
May 7, 2024: American Journal of Hypertension