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Sinonasal malignancy

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https://www.readbyqxmd.com/read/28050473/evaluation-of-sinonasal-diseases-by-computed-tomography
#1
Rashmi Kandukuri, Suresh Phatak
INTRODUCTION: Computed Tomography (CT) plays an important diagnostic role in patients with sinonasal diseases and determines the treatment. The CT images clearly show fine structural architecture of bony anatomy thereby determining various anatomical variation, extent of disease and characterization of various inflammatory, benign and malignant sinonasal diseases. AIM: To evaluate sensitivity and specificity of CT in diagnosis of sinonasal diseases and to characterise the benign and malignant lesions with the help of various CT parameters...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28050382/intestinal-type-adenocarcinoma-from-inverted-papilloma-a-rare-recurrence
#2
Garima Singh, Meeta Singh, Mansi Chandana, Sompal Singh, Namrata Nargotra
Inverted Papilloma (IP) is an uncommon and locally aggressive benign tumour of sinonasal region, which tends to recur after surgical resection. Most tumours are confined to the lateral nasal wall and sinuses, with maxillary sinus being most commonly affected and a male preponderance. It has a known association with in situ and invasive carcinomas with a <10% rate of malignant transformation. Most common association has been seen with squamous cell carcinoma and extremely rare association with adenocarcinoma and small cell carcinoma...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28044299/mucosal-malignant-melanoma-of-nasal-cavity-recurring-a-year-after-radiotherapy
#3
Cem Çomunoğlu, Gamze Mocan Kuzey, Mete Inançli, Füsun Baba, Hanife Özkayalar
OBJECTIVE: Sinonasal mucosal malignant melanoma is a rare entity. In this report we present a nasal mucosal malignant melanoma case with its histopathological and clinical features. CASE REPORT: An 88-year-old female patient presented with epistaxis a month ago. Examination revealed a polypoid mass lesion of right nasal cavity originating from the middle concha. Her medical history revealed that she had been found to have a mass lesion in the right nasal cavity 15 months ago...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28032687/transnasal-endoscopic-partial-maxillectomy-operative-nuances-and-proposal-for-a-comprehensive-classification-system-based-on-1378-cases
#4
Mario Turri-Zanoni, Paolo Battaglia, Apostolos Karligkiotis, Davide Lepera, Jacopo Zocchi, Iacopo Dallan, Maurizio Bignami, Paolo Castelnuovo
BACKGROUND: Despite the development of functional endoscopic endonasal surgery, there are still areas of the maxillary sinus that remain technically difficult to access using a standard middle meatal antrostomy as well as deep-seated skull base lesions requiring expanded transmaxillary approaches. METHODS: All patients who underwent transnasal endoscopic partial maxillectomy (TEPM) in a single institution from 2000 to 2014 were retrospectively reviewed. The TEPM was classified into 5 types according to the anatomic structures progressively removed and to the access provided...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28032289/sinonasal-renal-cell-like-carcinoma-case-report-and-review-of-the-literature
#5
Mark Kubik, Nicholas Barasch, Garret Choby, Raja Seethala, Carl Snyderman
The differential diagnosis for clear cell neoplasms of the sinonasal tract is wide but critical to understand. In this paper, we describe a case of renal cell-like adenocarcinoma (SNRCLA) presenting as a paranasal sinus mass with clear cell morphology. The relevant literature is reviewed and the workup for clear cell neoplasms described. SNRCLA is a rarely encountered low grade glandular malignancy of the paranasal sinuses. Despite its morphologic mimicry of renal cell carcinoma, SNRCLA demonstrates a seromucinous phenotype and is associated with a favorable prognosis and low recurrence rates after surgical resection...
December 28, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/28011179/therapy-of-sinonasal-malignancies-invading-the-orbit-orbital-exenteration-versus-preservation-of-the-orbit-plus-radiotherapy
#6
Ali-Farid Safi, Lars Behn, Daniel Rothamel, Orlando Guntinas-Lichius, Dirk Beutner, Hans-Joachim Nickenig, Joachim Zöller, Matthias Kreppel
INTRODUCTION: Orbital invasion is a strong independent prognostic factor for sinonasal malignancies. While there is consent about preservation of the orbit for tumors limited to the orbital periosteum there is controversy about the optimal management of sinonasal malignancies transgressing this barrier. Therefore the aim of our study was to compare exenteration versus preservation of the orbit. MATERIAL AND METHODS: 52 patients with sinonasal malignancies invading the orbit beyond the orbital periosteum with involvement of the orbital soft tissues were included in the retrospective study...
November 30, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28009605/melanotic-pecoma-of-the-sinonasal-mucosa-with-nono-tfe3-fusion-an-elusive-mimic-of-sinonasal-melanoma
#7
Stephanie M McGregor, Mir B Alikhan, Rahel A John, Howard Kotler, Julia A Bridge, Ibro Mujacic, Sabah Kadri, Jeremy Segal, Thomas Krausz
Perivascular epithelioid cell neoplasms (PEComas) are a family of mesenchymal tumors with features of both smooth muscle and melanocytic differentiation, with or without true melanin pigment. The highly variable morphology of PEComas results in a broad differential diagnosis that is also dependent on anatomic site. A subset demonstrates rearrangements involving the TFE3 (Xp11) locus, which can be used in diagnostically difficult cases. Here we describe a case of a melanotic PEComa with NONO-TFE3 fusion occurring in the sinonasal mucosa, as demonstrated by both next-generation sequencing and molecular cytogenetic studies...
December 22, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27993194/sinonasal-papillomas-in-a-private-referral-otorhinolaryngology-centre-review-of-22-years-experience
#8
Aderito de Sousa Fontes, Minaret Sandrea Jiménez, Nelson Urdaneta Lafée, Perfecto A Abreu Durán, Liwven E Quintana Páez, Andreina Carmina de Sousa de Abreu
OBJECTIVES: To evaluate the clinical presentation, treatment outcome and follow-up of all patients managed with sinonasal papillomas (SP), at a tertiary private otorhinolaryngology centre in Caracas (Venezuela). MATERIAL AND METHODS: We reviewed 94 patients with SP that were treated at our otolaryngology center, from July 1st 1993 to June 31st 2015. The demographic data, clinical features, radiological findings, anatomical origin, disease extension into the adjacent structures, surgical approaches performed, histopathology outcomes, recurrent risk, malignant transformation rate and coadjuvant therapies were assessed...
December 16, 2016: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/27930867/squamous-cell-carcinoma-associated-with-inverted-papilloma-of-the-maxillary-sinus-our-experience-with-21-patients
#9
Myeong Sang Yu, Won Sub Lim, Bong-Jae Lee, Yoo-Sam Chung
Sinonasal inverted papillomas (IP) are benign tumors, which represent 0.5-7.0% of all diagnosed sinonasal tumors,(1) and exhibit malignant characteristics, including high rates of recurrence and local aggressiveness and association with malignancy.(1) The incidence of IP associated with SCC differs widely according to various reports (2-53%).(2,3) IP-associated SCC is not considered to be simply a mixture of the two other primary tumors, but rather a malignant transformation of the IP.(3) This article is protected by copyright...
December 8, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27923935/radiographic-mastoid-and-middle-ear-effusions-in-intensive-care-unit-subjects
#10
Phillip Huyett, Yael Raz, Barry E Hirsch, Andrew A McCall
BACKGROUND: This study was conducted to determine the incidence of and risk factors associated with the development of radiographic mastoid and middle ear effusions (ME/MEE) in ICU patients. METHODS: Head computed tomography or magnetic resonance images of 300 subjects admitted to the University of Pittsburgh Medical Center neurologic ICU from April 2013 through April 2014 were retrospectively reviewed. Images were reviewed for absent, partial, or complete opacification of the mastoid air cells and middle ear space...
December 6, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27922925/update-on-nonmalignant-lesions-of-the-inferior-turbinate
#11
Jared M Goldfarb, David Goldfarb, Marc R Rosen
PURPOSE OF REVIEW: The inferior turbinates are routinely examined by otolaryngologists on anterior rhinoscopy and nasal endoscopy. Most lesions of the inferior turbinate are benign but can often be confused with malignancy. This review highlights the broad differential of nonmalignant lesions of the inferior turbinates and their management. RECENT FINDINGS: A variety of infectious, inflammatory, neoplastic, and vascular lesions may affect the inferior turbinates...
February 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/27917732/olfactory-neuroblastoma-14-year-experience-at-an-australian-tertiary-centre-and-the-role-for-longer-term-surveillance
#12
C Schmidt, N Potter, S Porceddu, B Panizza
BACKGROUND: Olfactory neuroblastoma is a rare sinonasal malignancy, with poorly defined treatment protocols. Management at a tertiary centre was retrospectively evaluated to inform future treatment and follow up. METHODS: Cases treated with curative intent (2000-2014) were included. Data were collected, and overall and disease-free survival rates were calculated. RESULTS: Eleven cases were identified, with a median follow up of 87 months. One patient was Kadish stage A, one was stage B, eight were stage C and one was stage D...
December 5, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27914687/braf-nras-kit-tert-gnaq-gna11-mutation-profile-analysis-of-head-and-neck-mucosal-melanomas-a-study-of-42-cases
#13
Şule Öztürk Sari, İsmaİl Yilmaz, Orhun Çiğ Taşkin, Gİzem Narli, Fatma Şen, Şenol Çomoğlu, Pinar Firat, Bİlge Bİlgİç, Dİlek Yilmazbayhan, Yasemİn Özlük, Nesİmİ Büyükbabanİ
Head and neck mucosal melanoma (HNMuM), which occurs mostly in the sinonasal and oral cavity, constitutes less than 1% of all malignant melanomas. Treatment options fail to improve the prognosis of this aggressive tumour that has low overall survival rates. Thus, development of new targeted therapies is essential. Unfortunately, limited data exist regarding their molecular profile. BRAF, NRAS, KIT, TERT and GNAQ/GNA11 oncogene mutations were investigated in 42 HNMuMs (28 sinonasal, 13 oral, 1 nasopharyngeal)...
January 2017: Pathology
https://www.readbyqxmd.com/read/27894610/-reconstruction-of-proximal-nasal-defect-after-deep-carcinological-resection-interest-to-combine-titane-mesh-with-fat-grafting
#14
R Aimard, C Lalloué, C Ho Quoc, D Girodet, P Zrounba, E Delay
INTRODUCTION: The mucosal cylindroma or adenoid cystic carcinoma is the second sinonasal non-epithelial malignant tumor frequency argument. Due to the achievement of the nasal mucosa and a late diagnosis reconstructions are often complex. We report the case of a mucous cylindroma recurrence of nasal septum requiring a wide and deep excision of the root of the nose with nasal reconstruction. CASE REPORT: A patient aged 66 years whose history resection two years ago with a mucous adenoid cystic carcinoma of the right side of the nasal septum, had a local recurrence T2NOM0 imposing a wide excision with amputation nasal septum own bones of nose, the anterior portion of the triangular cartilages...
November 25, 2016: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/27859290/small-cell-carcinoma-of-the-head-and-neck-a-comparative-study-by-primary-site-based-on-population-data
#15
Edward C Kuan, Jose E Alonso, Bobby A Tajudeen, Armin Arshi, Jon Mallen-St Clair, Maie A St John
OBJECTIVES/HYPOTHESIS: Small cell carcinoma (SmCC) of the head and neck is an extremely rare neuroendocrine malignancy. In this study, we describe the incidence and determinants of survival of patients with SmCC of the head and neck between the years of 1973 and 2012 using the Surveillance, Epidemiology, and End Results database as differed by primary site. STUDY DESIGN: Retrospective, population-based cohort study. METHODS: A total of 237 cases of SmCC of the head and neck were identified, which was divided into sinonasal primaries (n = 82) and all other head and neck primaries (n = 155)...
November 17, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27857871/sinonasal-carcinomas-with-neuroendocrine-features-histopathological-differentiation-and-treatment-outcomes
#16
Liuba Soldatova, Raewyn G Campbell, Ricardo L Carrau, Daniel M Prevedello, Paul Wakely, Bradley A Otto, Leo F Ditzel Filho
Objectives Sinonasal cancers with neuroendocrine features share similar clinical, radiological, and histopathological features; however, these tumors often exhibit varying degrees of aggressive behavior presenting significant treatment challenges. The objective of this study was to report our experience with these rare malignancies and to present a review of current literature. Methods Following institutional review board approval, the records of all patients with biopsy-proven sinonasal malignancies over a 5-year period were reviewed...
December 2016: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/27846019/posttreatment-surveillance-for-sinonasal-malignancy
#17
Alan D Workman, James N Palmer, Nithin D Adappa
PURPOSE OF REVIEW: Sinonasal neoplasms have a high rate of recurrence following treatment, and clinicians utilize a variety of surveillance techniques. Generally, surveillance modality and frequency of follow-up are determined by the guidelines for head and neck cancer as a broad category. However, recent studies have demonstrated that a more tailored approach to follow-up may be necessary. RECENT FINDINGS: Endoscopy has low sensitivity in recurrence detection, especially in the asymptomatic patient...
February 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/27810139/expression-and-clinical-significance-of-trkb-in-sinonasal-squamous-cell-carcinoma-a-pilot-study
#18
L Li, L Zhu
Previous studies have confirmed that tropomyosin-related kinase B (TrkB) plays a critical role in the occurrence, development, and metastasis of many kinds of malignant tumour. More recently, TrkB was found to be overexpressed in head and neck squamous cell carcinoma (SCC) and to be involved in multistep tumour progression. In this study, the expression of TrkB was investigated in 27 cases of sinonasal SCC using an immunohistochemical method. The clinical significance and possible role of TrkB as a prognostic marker in these tumours was also explored...
February 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27758016/diffusion-kurtosis-imaging-for-differentiating-between-the-benign-and-malignant-sinonasal-lesions
#19
Jing Xuan Jiang, Zuo Hua Tang, Yu Feng Zhong, Jin Wei Qiang
PURPOSE: The study aimed to evaluate diffusion kurtosis imaging (DKI) in the differentiation between benign and malignant sinonasal lesions, and to compare the diagnostic performance of DKI with diffusion weighted imaging (DWI). MATERIALS AND METHODS: Eight-one patients with solid sinonasal lesions confirmed by surgery and pathology (46 malignant and 35 benign) underwent conventional MRI, DWI, and DKI. DKI was performed employing a 13 extended b-value ranging from 0 to 2500 s/mm(2) ...
October 19, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27748287/spectrum-of-aids-defining-non-aids-defining-malignancies-in-north-india
#20
Ravinder Kaur Sachdeva, Aman Sharma, Surjit Singh, Subhash Varma
BACKGROUND & OBJECTIVES: There is scarcity of data on the frequency of malignancies in HIV infected individuals from India. The objective of this study was to determine the type and frequency of malignancies in HIV infected individuals attending a tertiary care hospital in north India. METHODS: The study design included retrospective analysis of data of all HIV infected individuals registered in the Immunodeficiency clinic from December 2009 to December 2011 and a prospective analysis of HIV infected individuals registered from January 2012 to April 2013...
May 2016: Indian Journal of Medical Research
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