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Sinonasal malignancy

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https://www.readbyqxmd.com/read/28903848/prosthetic-rehabilitation-of-a-partially-edentulous-patient-with-maxillary-acquired-defect-by-a-two-piece-hollow-bulb-obturator-using-a-dentogenic-concept
#1
Poonam R Kulkarni, Rahul S Kulkarni, Rupal J Shah, Kavita Maru
Patients may face functional, aesthetic, and social distress because of the palatal defects. Prosthetic rehabilitation of maxillectomy or developmental defect can be challenging for prosthodontists. Prognosis of the prosthetic appliances can be affected not only by patients' own ability to adapt to the prosthesis but also by the factors like the remaining teeth, bony structure, and existing mucosa. Maxillary defects are usually developed by surgical intercession of the benign or malignant conditions and trauma cases...
August 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28875123/costs-and-perioperative-outcomes-associated-with-open-versus-endoscopic-resection-of-sinonasal-malignancies-with-skull-base-involvement
#2
Terence S Fu, Eric Monteiro, Ian Witterick, Allan Vescan, Gelareh Zadeh, Fred Gentili, John R de Almeida
Objective  To compare financial and perioperative outcomes between endoscopic and open surgical approaches in the surgical management of sinonasal malignancies. Design  Retrospective chart review. Setting  Tertiary care hospital. Participants  Patients undergoing surgical resection of a sinonasal malignancy from January 2000 to December 2014. Main Outcome Measures  In-hospital costs, complications, and length of stay (LOS). Results  Of 106 patients, 91 received open surgery (19 free flap and 72 non-free flap) and 15 were treated with purely endoscopic approaches...
October 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28875122/the-utility-of-sentinel-node-biopsy-for-sinonasal-melanoma
#3
Michael S Oldenburg, Daniel L Price
Objective  Report two positive sentinel node biopsies for sinonasal melanoma. Design  Retrospective review. Setting  Academic tertiary care center. Participants  Patients who underwent sentinel node biopsy for sinonasal melanoma between November 1, 2014 and November 1, 2015. Main Outcome Measures  Clinical course. Results  Two patients were identified. Patient 1 (83M) presented with a sinonasal melanoma anterior to the left inferior turbinate and was clinically N0 neck. Lymphoscintigraphy revealed two sentinel nodes in the ipsilateral and three in the contralateral cervical basins...
October 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28872554/detection-of-non-fdg-avid-residual-sinonasal-malignant-melanoma-in-the-skull-base-with-11c-choline-pet-and-contrast-enhanced-mri
#4
Chunxia Qin, Fan Hu, Maher Mohamad Rajab Arnous, Xiaoli Lan
Primary sinonasal melanoma is a rare disease. We present a case of melanoma in sinuses without abnormal F-FDG activity anywhere in the scanned portion of the body. In further assessment, C-choline PET/CT revealed high activity in the paranasal sinuses, skull base, and adjacent brain, in agreement with the high signal on contrast-enhanced T1-weighted MRI scan, which suggested the residual tumor.
September 1, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28871554/the-impact-of-histologic-phenotype-in-the-treatment-of-sinonasal-cancer
#5
REVIEW
Fernando López, Valerie J Lund, Carlos Suárez, Carl H Snyderman, Nabil F Saba, K Thomas Robbins, Vincent Vander Poorten, Primož Strojan, William M Mendenhall, Alessandra Rinaldo, Alfio Ferlito
The management of sinonasal cancer is a challenge due to its low occurrence and anatomical and significant diversity of histological types. The therapeutic modality used should be tailored individually according to the histology, tumour stage, molecular profile and previous treatments. The clinical management of sinonasal cancer has improved greatly owing to developments in endoscopic surgery and precision radiotherapy. Complete surgical resection is the mainstay of sinonasal malignancies' management but multimodality therapy is associated with improved outcomes in certain histologies...
September 4, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28869195/-proton-therapy-for-head-and-neck-cancers
#6
P Blanchard, S J Frank
The absence of exit dose and the sharp lateral penumbra are key assets for proton therapy, which are responsible for its dosimetric superiority over advanced photon radiotherapy. Dosimetric comparisons have consistently shown a reduction of the integral dose and the dose to organs at risk favouring intensity-modulated proton therapy (IMPT) over intensity-modulated radiotherapy (IMRT). The structures that benefit the most of these dosimetric improvements in head and neck cancers are the anterior oral cavity, the posterior fossa, the visual apparatus and swallowing structures...
August 28, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28869103/clinical-manifestations-and-stk11-germline-mutations-in-taiwanese-patients-with-peutz-jeghers-syndrome
#7
Jy-Ming Chiang, Tse-Ching Chen
BACKGROUNDS: Clinical manifestations and molecular basis of Taiwanese patients with Peutz-Jeghers syndrome (PJS) were investigated to add the knowledge of phenotype and genotype of the disease. METHODS: Based on the Pathology Data Bank and the Colorectal Cancer Register, we collected their clinical data. The entire coding sequence of the STK11 gene was amplified and analyzed by sequencing using the genomic DNA. RESULTS: Fifteen patients diagnosed with PJS from 11 unrelated families were collected until 2015...
August 28, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28868018/spinal-cord-compression-secondary-to-metastatic-sinonasal-undifferentiated-carcinoma
#8
Arthur Wang, John V Wainwright, Anubhav G Amin, Eric Vail, Rachel Silverstein, Kaushik Das
Sinonasal undifferentiated carcinoma (SNUC) is a rare malignancy of the upper airways and anterior skull base that carries a poor prognosis. The tumor is known to be invasive into the surrounding structures of the skull base and brain. To date, there is only one existing case report documenting drop metastasis to the intradural extramedullary spinal cord. To the best of our knowledge, we present the second case of metastatic SNUC to the spine. This report describes a 59-year-old male with a history of head and neck SNUC who presented with thoracic back pain and bilateral lower extremity paresis...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28865090/sinonasal-quality-of-life-after-endoscopic-resection-of-malignant-sinonasal-and-skull-base-tumors
#9
Jordan T Glicksman, Arjun K Parasher, Steven G Brooks, Alan D Workman, Justina L Lambert, Jenna E Bergman, James N Palmer, Nithin D Adappa
OBJECTIVES: Improvement in sinonasal quality of life (QoL) following sinus surgery has been well-documented across the literature. To our knowledge, only one series has evaluated long-term QoL in patients undergoing tumor resection, and that study demonstrated no improvement in rhinologic QoL following malignant tumor resection at 2-year follow-up. The objective of the present study was to evaluate QoL in the 2 years following endoscopic malignant tumor resection. METHODS: A prospective cohort study was performed, including patients with both malignant and benign sinonasal tumors in a tertiary academic medical center...
September 2, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28865078/epidemiology-and-survival-outcomes-of-sinonasal-verrucous-carcinoma-in-the-united-states
#10
Jose E Alonso, Albert Y Han, Edward C Kuan, Jeffrey D Suh, Maie A St John
INTRODUCTION: Verrucous carcinoma (VC) is a rare, variant of squamous cell carcinoma with benign cytohistopathologic features and a generally favorable prognosis. Epidemiologic and clinical outcomes data are lacking as a result of limited cases of sinonasal VC. OBJECTIVE: To describe the incidence and determinants of survival of patients with verrucous carcinoma of the sinonasal tract between the years of 1973 to 2014 using the Surveillance, Epidemiology, and End Results (SEER) database...
September 2, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28860918/accidentally-diagnosed-transitional-cell-papilloma-of-the-lacrimal-sac
#11
Tarjani Vivek Dave, Dilip Mishra, Ruchi Mittal, Mohammad Javed Ali
Lacrimal sac tumors are extremely rare but can be life threatening. Seventy percent of lacrimal sac tumors are of epithelial origin. Inverted transitional cell papilloma of the lacrimal sac is a rare epithelial sinonasal tumor of benign etiology with local invasion and malignant potential. These lesions may remain undiagnosed or may present with signs and symptoms of dacryocystitis or may transform to transitional cell carcinomas. Most lesions are diagnosed intra-operatively while performing a dacryocystorhinostomy...
July 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28859706/outcomes-of-sinonasal-squamous-cell-carcinoma-with-and-without-association-of-inverted-papilloma-a-multi-institutional-analysis
#12
Brian C Lobo, Brian D'Anza, Janice L Farlow, Dennis Tang, Troy D Woodard, Jonathan Y Ting, Raj Sindwani
INTRODUCTION: Sinonasal squamous cell carcinoma (SCC) accounts for <1% of all malignancies but represents 70% of sinonasal cancer. Up to 10% of SCCs are associated with inverted papilloma (IPSCC). Studies that compare patients, treatment, and outcomes of SCC and IPSCC are absent in the literature. METHODS: A retrospective review of patients with SCC and those with IPSCC at Cleveland Clinic and Indiana University from 1995 to 2015. The records were analyzed for demographics, tumor characteristics, treatment, and outcomes...
September 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28815617/disparities-in-sinonasal-squamous-cell-carcinoma-short-and-long-term-outcomes-analysis-from-the-national-cancer-database
#13
Ryan M Carey, Arjun K Parasher, Alan D Workman, Carol H Yan, Jordan T Glicksman, Jinbo Chen, James N Palmer, Nithin D Adappa, Jason G Newman, Jason A Brant
OBJECTIVES/HYPOTHESIS: To examine sociodemographic, hospital-specific, and disease-related characteristics in relation to outcomes in sinonasal squamous cell carcinoma (SCC). STUDY DESIGN: The National Cancer Database was queried for location codes corresponding to the nasal cavity and paranasal sinuses and histology codes representing SCC malignancy. Multivariate analyses were performed against short- and long-term outcomes (overall survival, days to discharge, 30-day readmission, and 30- and 90-day mortality)...
August 16, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28809123/-18-fdg-pet-ct-in-routine-surveillance-of-asymptomatic-patients-following-treatment-of-sinonasal-neoplasms
#14
Alan D Workman, Jordan T Glicksman, Arjun K Parasher, Ryan M Carey, Steven G Brooks, David W Kennedy, Seyed A Nabavizadeh, Kim O Learned, James N Palmer, Nithin D Adappa
Objective Sinonasal neoplasms have a high rate of recurrence following treatment, and current guidelines support the use of a variety of surveillance techniques. Recent work demonstrates that performance parameters of surveillance modalities may differ with sinonasal tumors in particular when compared with head and neck tumors overall. This study aims to characterize the value of (18)fluorodeoxyglucose ((18)FDG) positron emission tomography/computed tomography (PET/CT) as a screening tool in asymptomatic patients...
August 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28799187/safety-evaluation-of-combination-carboplatin-and-toceranib-phosphate-palladia-in-tumour-bearing-dogs-a-phase-i-dose-finding-study
#15
R M Wouda, S E Hocker, M L Higginbotham
Combining conventional cytotoxic maximum tolerated dose (MTD) chemotherapy with low-dose metronomic and/or anti-angiogenic agents is a exciting area of oncologic research. The objective of this study was to establish the MTD, safety and adverse event (AE) profile of 1 such drug combination. This prospective phase I dose-finding clinical trial assumed an open-label 3 + 3 cohort design. Client-owned dogs with 1 or more cytologically and/or histologically confirmed and macroscopically measurable, naive or recurrent, malignant tumours, were enrolled...
August 10, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28798001/giant-primary-sinonasal-mucosal-melanoma-a-rare-malignancy
#16
Mehtab Alam, Mohd Aslam, Piyush Kant Singh, Shahab Farkhund Hashmi, Syed Abrar Hasan
It is extremely rare to find a case of primary sinonasal mucosal melanoma, which is more aggressive and have poorer outcome than its cutaneous counterpart. This tumour is refractory to the treatment which includes wide surgical excision with or without adjuvant postoperative radiotherapy. We are reporting a case of 60 year old female who presented with right sided nasal mass and facial deformity, in whom the diagnosis of mucosal melanoma was made on histopathological examination and confirmed by immunohistochemistry...
May 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28775129/comprehensive-molecular-profiling-of-olfactory-neuroblastoma-identifies-potentially-targetable-fgfr3-amplifications
#17
Lorena Lazo de la Vega, Jonathan B McHugh, Andi K Cani, Komal Kunder, Frances M Walocko, Chia-Jen Liu, Daniel H Hovelson, Dan R Robinson, Arul M Chinnaiyan, Scott A Tomlins, Paul W Harms
Olfactory neuroblastomas (ONBs), also known as esthesioneuroblastomas, are malignant round-cell tumors that represent up to 5% of sinonasal malignancies. Despite their aggressive course, molecular studies of ONBs have been limited, and targeted therapies are lacking. To identify potential oncogenic drivers and targetable pathways in ONBs, we characterized 20 ONBs, including archived ONBs profiled by targeted, multiplexed PCR (mxPCR) based DNA next generation sequencing (NGS) of the coding sequence of over 400 cancer-relevant genes (n=16), mxPCR based RNA NGS of 108 target genes (n=15), and two ONBs profiled by comprehensive hybrid-capture based clinical grade NGS of >1,500 genes...
August 3, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28767609/sinonasal-renal-cell-like-adenocarcinoma-a-unique-variant-of-primary-clear-cell-carcinoma-of-the-head-and-neck-the-first-reported-case-in-korea
#18
Nah-Ihm Kim, Jung-In Yang, Sung-Sun Kim, Ji-Shin Lee, Sang-Chul Lim, Shin Jung, Jae-Hyuk Lee, Kyung-Sub Moon, Kyung-Hwa Lee
RATIONALE: Primary sinonasal renal cell-like adenocarcinoma (SNRCLA) is a rare and unique neoplasm. PATIENT CONCERNS: A 63-year-old man presented with repeated epistaxis, nasal obstruction and hyposmia of 2-month duration. Radiological studies revealed a mass of the left ethmoid sinus involving anterior skull base. DIAGNOSIS: The patient was treated with craniofacial resection, bifrontal craniotomy combined with an endonasal endoscopic approach...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28740564/can-diffusion-weighted-imaging-aid-in-differentiating-benign-from-malignant-sinonasal-masses-a-useful-adjunct
#19
Abanti Das, Ashu S Bhalla, Raju Sharma, Atin Kumar, Alok Thakar, Sreenivas M Vishnubhatla, Mehar C Sharma, Suresh C Sharma
BACKGROUND: To evaluate the role of diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) values at 3 Tesla in characterizing sinonasal masses. MATERIAL/METHODS: After ethical clearance, 79 treatment naive patients with head and neck masses underwent magnetic resonance imaging (MRI), including DWI at 3 Tesla using the following b values - 0, 500 and 1000 s/mm(2). Thirty-one patients were found to have sinonasal tumours and were subsequently analysed...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28734993/esthetically-favorable-surgical-alternative-for-the-removal-of-sinonasal-malignant-tumors-the-modified-facial-degloving-technique
#20
REVIEW
Gábor Vass, Zsolt Bella, Zoltán Tóbiás, Attila Nagy, László Iván, László Rovó
PURPOSE: The widely used external approach (Weber-Fergusson incision) for the removal of maxillary ethmoid tumors leaves stigmatizing scars and deformities on the patient's face. As an alternative technique, the scarless facial degloving approach was first described in the 1970s; since then, several modifications have been developed. PATIENTS AND METHODS: The authors have been using a modified facial degloving technique for 7 years to remove maxillary ethmoid tumors...
June 29, 2017: Journal of Oral and Maxillofacial Surgery
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