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Sinonasal malignancy

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https://www.readbyqxmd.com/read/28523315/sinonasal-non-hodgkin-s-malignant-lymphoma-review-of-a-clinical-case
#1
Vlad Andrei Budu, Mihail Tuşaliu, Tatiana Decuseară, Ioan Alexandru Bulescu, Cristiana Gabriela Popp, Alexandru Panfiloiu, Andreea Nicoleta Costache, Iuliana Lupu, Carmen Aurelia Mogoantă
Malignant lymphomas represent one of the most important problems of modern medicine, with a constant increase in the last decades, becoming the most frequent tumor among young people. Sinonasal localization is a particular site of malignant lymphomas, representing the second most frequent among ear, nose and throat (ENT) tumors. In this paper, authors present the clinical, diagnostic and therapeutic aspects of a malignant sinonasal lymphoma, which despite an aggressive histological subtype and important regional extension had a favorable clinical outcome...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28497509/characteristics-and-prognosis-of-glomangiopericytomas-a-systematic-review
#2
REVIEW
Eun Su Park, Jiyoung Kim, Sun-Young Jun
BACKGROUND: Glomangiopericytoma belongs to the category of borderline/low-malignant-potential tumors of the sinonasal tract, but no studies about prognosis have been reported. METHODS: To define the characteristics of glomangiopericytoma and to identify its prognostic factors, a systematic review was performed. A total of 337 cases of glomangiopericytomas were analyzed. RESULTS: Patients with glomangiopericytoma demonstrating resection margin involvement and receiving radiotherapy/chemotherapy had a significantly worse disease-free survival time (P =  ...
May 12, 2017: Head & Neck
https://www.readbyqxmd.com/read/28496329/minimally-invasive-endoscopic-resection-for-the-treatment-of-sinonasal-malignancy-the-outcomes-and-risk-factors-for-recurrence
#3
Ning He, Xiaohong Chen, Luo Zhang, Xuejun Chen, Zhigang Huang, Qi Zhong, Hongzhi Ma, Ling Feng, Lizhen Hou, Jugao Fang
PURPOSE: The role of minimally invasive endoscopic resection (MIER) in the treatment of sinonasal malignancy is controversial. Herein, we performed a retrospective review of a large case series of sinonasal malignancy patients treated with MIER aimed at evaluating the outcomes and identifying the risk factors for recurrence. METHODS: Patients with sinonasal malignancy who underwent MIER from March 2000 to May 2015 were enrolled, and their clinical data were collected...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28493366/frequent-idh2-r172-mutations-in-undifferentiated-and-poorly-differentiated-sinonasal-carcinomas
#4
Snjezana Dogan, Deborah J Chute, Bin Xu, Ryan N Ptashkin, Raghu Chandramohan, Jacklyn Casanova-Murphy, Khedoudja Nafa, Justin A Bishop, Simion I Chiosea, Edward B Stelow, Ian Ganly, David G Pfister, Nora Katabi, Ronald A Ghossein, Michael F Berger
Sinonasal undifferentiated carcinoma (SNUC) is a high-grade malignancy with limited treatment options and poor outcome. A morphologic spectrum of 47 sinonasal tumors including 17 (36.2%) SNUCs were analyzed at genomic level. Thirty carcinomas (Cohort 1) were subjected to a hybridization exon-capture next-generation sequencing assay (MSK-IMPACT(TM) ) to interrogate somatic variants in 279 or 410 cancer-related genes. Seventeen sinonasal tumors (Cohort 2) were examined only for presence of IDH1/2 exon 4 mutations by Sanger sequencing...
May 11, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28490408/endoscopic-resection-of-sinonasal-mucosal-melanoma-has-comparable-outcomes-to-open-approaches
#5
Amar Miglani, Samir H Patel, Heidi E Kosiorek, Michael L Hinni, Richard E Hayden, Devyani Lal
BACKGROUND: Endoscopic endonasal resection (EER) of sinonasal mucosal melanoma (SMM) is a newer surgical alternative to traditional external and/or open resection (OR). Studies on long-term outcomes are necessary to validate EER for this aggressive sinonasal malignancy. OBJECTIVE: To compare outcomes of EER versus OR in SMM. METHODS: A case series of patients who underwent surgical resection of SMM at a tertiary-care institution (2000-2015) was studied retrospectively...
May 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28484539/sinonasal-teratocarcinosarcoma-involving-nasal-cavity-nasopharynx-and-all-paranasal-sinuses-with-bilateral-orbital-and-intracranial-extension-a-rare-case-report
#6
Dhruba Jyoti Kurmi, Radhey Shyam Mittal, Achal Sharma, Ashok Gandhi, Shashi Singhvi
Sinonasal teratocarcinosarcoma (SNTCS) is one of the rarest, aggressive malignant neoplasms of sinonasal tract, consisting of primitive neuroepithelial elements with various malignant epithelial and mesenchymal components. Previously described as teratoid carcinosarcoma, malignant teratoma, or blastoma, SNTCS constitutes less than 1% of all cancers and approximately 3% of all malignancies of head and neck region, which is mainly located in the nasal cavity and paranasal sinuses, although tumors occurring in other locations including the nasopharynx and oral cavity have been described...
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28479047/the-analysis-of-expression-of-p16-protein-in-group-of-53-patients-treated-for-sinonasal-inverted-papilloma
#7
Roland Zydroń, Andrzej Marszałek, Magdalena Bodnar, Paweł Kosikowski, Grażyna Greczka, Małgorzata Wierzbicka
INTRODUCTION: Sinonasal Inverted Papilloma (IP) constitute relevant therapeutic problem due to destructive character of growth, tendency to recur and the possibility of malignant transformation. Therefore, many attempts to identify risk factors for IP occurrence have been undertaken, as well as research to find markers that would allow for the earlier detection of tumors and the application of adequate therapy. A widely known risk factor of IP is HPV infection. One of the markers of HPV infection and the ongoing effect of this change (although arousing some controversy) is the expression of the p16 protein...
April 19, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28473663/expression-pattern-of-estroprogestinic-receptors-in-sinonasal-inverted-papilloma
#8
Agostino Serra, Rosario Caltabiano, Giacomo Spinato, Salvatore Gallina, Salvatore Caruso, Venerando Rapisarda, Paola Di Mauro, Veronica Castro, Angelo Conti, Luisa Licciardello, Luigi Maiolino, Salvatore Lanzafame, Salvatore Cocuzza
Inverted papilloma (IP) is a locally destructive, benign neoplasm of the nose and paranasal sinuses with a high tendency for recurrence, a significant potential for malignancy, and an etiology that today is still uncertain. The expression of hormonal receptors in neoplastic tissues has been the focus of intensive research for its potential diagnostic, prognostic, and therapeutic significance. The aim of this study was to assess the potential estroprogestinic receptor expression in patients undergoing sinus surgery for IP...
April 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28455406/role-of-narrow-band-imaging-in-the-diagnostics-of-sinonasal-pathology
#9
Kristian Bruun Petersen, Thomas Kjaergaard
Malignancies of the nasal cavity and paranasal sinuses are well known, but have uncommon presentations. Late diagnosis and local extension are significant prognostic factors associated with a poorer treatment outcome. Thus, refinements of the diagnostic procedures to enhance the sensitivity of the clinical evaluation are desirable. We here describe a case of endonasal lymphoma, in which the lesion was hardly visible and initially ignored at ordinary white light (WLI) nasoendoscopy, but easily recognisable, clearly pathogenic and well demarcated when illuminated with narrow band imaging (NBI) at a later session...
April 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28447903/low-grade-sinonasal-sarcoma-with-neural-and-myogenic-features-a-recently-discovered-entity-with-unique-features-and-diagnostic-challenge
#10
Meriam Triki, Lobna Ayadi
Low-grade sinonasal sarcoma with neural and myogenic features is an entity recently described in the literature. Little is known about its etiopathogenesis, natural history, or optimal treatment. In fact, it has relatively unique findings: it has a distinctive cytogenetic signature, and it expresses both smooth muscle actin and S100 protein. However, its diagnosis is challenging on biopsies showing negative staining for these 2 markers. The differential diagnoses include fibrosarcoma, malignant peripheral nerve sheath tumors, and other benign and malignant lesions...
May 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28443572/primary-sinonasal-malignant-melanoma-effect-of-clinical-and-histopathologic-prognostic-factors-on-survival
#11
Sercan Göde, Göksel Turhal, Ceyda Tarhan, Banu Yaman, Gülsen Kandıloğlu, Kerem Öztürk, İsa Kaya, Raşit Midilli, Bülent Karcı
BACKGROUND: Mucosal melanoma is a rare malignancy arising from melanocytes of the mucosal surfaces. The pattern and frequency of oncogenic mutations and histopathologic biomarkers have a role on distinct tumor behaviour and survival. AIMS: The aim of this study was to assess the rate of c-kit positivity and its effect on survival of surgically treated sinonasal malignant melanoma (SMM) patients with other histopathologic biomarkers and clinical features. STUDY DESIGN: This is a retrospective cross-sectional study...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28442409/sinonasal-mucosal-melanoma-a-44-case-study-and-literature-analysis
#12
M Dréno, M Georges, F Espitalier, C Ferron, A Charnolé, B Dréno, O Malard
OBJECTIVES: Sinonasal mucosal melanoma is a rare disease, representing 4% of nasal cavity and paranasal sinus malignancies. The aim of this study was to assess the clinical characteristics, progression and treatment of this disease and to identify prognostic factors. MATERIAL AND METHODS: This retrospective review presents a cohort of 44 patients treated for a melanoma arising from the nasal cavity and paranasal sinuses, in the ENT Head and Neck Surgery Department of the University Hospital of Nantes (France) between 1988 and 2015...
April 22, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28439688/erratum-to-endonasal-endoscopic-surgery-in-the-management-of-sinonasal-and-anterior-skull-base-malignancies
#13
Christopher R Roxbury, Masaru Ishii, Jeremy D Richmon, Ari M Blitz, Douglas D Reh, Gary L Gallia
No abstract text is available yet for this article.
April 24, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28432463/malignant-transformation-of-sinonasal-inverted-papilloma-and-related-genetic-alterations-a-systematic-review
#14
REVIEW
M Re, F M Gioacchini, A Bajraktari, M Tomasetti, S Kaleci, C Rubini, A Bertini, G Magliulo, E Pasquini
Schneiderian papillomas are uncommon tumors which may develop within the nasal cavity and comprise three well-defined histological types: sinonasal inverted papilloma (SNIP), exophytic papilloma, and oncocytic papilloma. It is well known the rate of Schneiderian papilloma may also present a malignant degeneration and SNIP represents the most important subgroup in consideration of its frequency and malignant propensity. Although HPV infection is always considered the first event favoring the development of SNIP, however, it is not established as an eventual connection between viral actions and malignant transformation...
April 21, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28391433/a-peutz-jeghers-syndrome-family-associated-with-sinonasal-adenocarcinoma-28-years-follow-up-report
#15
Jy-Ming Chiang, Tse-Ching Chen
Peutz-Jeghers syndrome (PJS) is a rare hereditary disorder characterized by hamartomatous polyps in both of the gastrointestinal tract and mucosal pigmentation. It could increase in risk of intestinal and extra-intestinal neoplasms. We here described three cases of sinonasal polyposis in a PJS family and two developed sinonasal type adenocarcinoma. Genetic study revealed a germline STK11/LKB1 mutation on codon 179 (c.C536G, p.P179R) of exon 4. LOH analysis of the LKB1 locus confirms this to be a deleterious mutation...
April 8, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28374875/idiopathic-siadh-in-young-patients-don-t-forget-the-nose
#16
C Parrilla, D Lucidi, G Petrone, G Bastanza, C Colosimo
Olfactory neuroblastoma (ONB) is an uncommon neuroendocrine sinonasal cancer associated by many authors to ectopic production of several biologically active substances. We report a case of a 31-year-old male patient who presented with idiopathic syndrome of inappropriate secretion of antidiuretic hormone (SIADH). During diagnostic work-up, a CT scan of the head was performed and an ethmoidal ONB was detected. Endoscopical surgery followed by radiotherapy was carried out. Immediately after surgery natraemia levels normalised...
February 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28369832/a-comprehensive-comparative-analysis-of-treatment-modalities-for-sinonasal-malignancies
#17
Tyler P Robin, Bernard L Jones, Oren M Gordon, Andy Phan, Diana Abbott, Jessica D McDermott, Julie A Goddard, David Raben, Ryan M Lanning, Sana D Karam
BACKGROUND: Sinonasal malignancies are a rare and heterogeneous group of tumors for which there is a paucity of robust data with which to guide management decisions. The authors used the National Cancer Data Base to better understand the presenting characteristics of these tumors and to compare outcomes by treatment modality. METHODS: The National Cancer Data Base was queried for sinonasal malignancies diagnosed between 2004 and 2012. Overall survival was assessed using multivariate analyses and propensity score matching...
April 3, 2017: Cancer
https://www.readbyqxmd.com/read/28321771/osps-and-esps-and-isps-oh-my-an-update-on-sinonasal-schneiderian-papillomas
#18
Justin A Bishop
Sinonasal (Schneiderian) papillomas are benign neoplasms that arise in the sinonasal tract. Since their initial descriptions, sinonasal papillomas have triggered debate regarding their classification, etiology, rate or predictors of malignant transformation, and other issues. While significant strides have been made in recent years, there are still aspects of sinonasal papillomas that remain unclear even now. This review will serve to update the practicing pathologist on the current understanding of sinonasal papillomas...
March 20, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28314409/sinonasal-and-ventral-skull-base-malignancies
#19
EDITORIAL
Jean Anderson Eloy, Michael Setzen, James K Liu
No abstract text is available yet for this article.
April 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28314407/population-based-results-in-the-management-of-sinonasal-and-ventral-skull-base-malignancies
#20
REVIEW
Rami Abdou, Soly Baredes
Population-based cancer registries allow for data collection on the scale of large populations, outside the limits of a single institution, and facilitate study of rare entities. The SEER database has been used to study more than 7000 cases encompassing a wide variety of relatively rare sinonasal malignant histologies. Clinically useful parameters have been gleaned from these analyses. Important limitations, such as omission of chemotherapy data, surgical approach used, type of radiation administered, and selection and confounding bias, should be considered...
April 2017: Otolaryngologic Clinics of North America
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