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Sinonasal malignancy

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https://www.readbyqxmd.com/read/29779136/genetic-mutation-analysis-of-the-malignant-transformation-of-sinonasal-inverted-papilloma-by-targeted-amplicon-sequencing
#1
Shinichiro Yasukawa, Satoshi Kano, Hiromitsu Hatakeyama, Yuji Nakamaru, Dai Takagi, Takatsugu Mizumachi, Masanobu Suzuki, Takayoshi Suzuki, Akira Nakazono, Shinya Tanaka, Hiroshi Nishihara, Akihiro Homma
BACKGROUND: The mechanism underlying the malignant transformation of inverted papilloma (IP) has not yet been elucidated. METHODS: To clarify the genes responsible for the malignant transformation, we analyzed 10 cases of IP, 8 of IP with dysplasia, and 11 of squamous cell carcinoma (SCC) by targeted amplicon sequencing. RESULTS: The number of mutant genes increased in the order of IP < dysplasia < SCC. Significant differences were observed in the mutation rates of three genes (KRAS, APC and STK11) in particular...
May 19, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29765826/rates-and-locations-of-regional-metastases-in-sinonasal-malignancies-the-mayo-clinic-experience
#2
Brandon W Peck, Kathryn M Van Abel, Eric J Moore, Daniel L Price
Objectives  The objective of this study was to identify factors that may influence the rate and location of regional metastasis in sinonasal malignancies (SNMs). Design  This is a retrospective review. Setting  This study was set at the single-institution tertiary referral center. Participants  A total of 299 patients were treated for SNMs from 1994 to 2014. Main Outcome Measures  The main outcome measures were incidence and distribution of regional metastases. Results  Several histologic subtypes were treated, with squamous cell carcinoma (28...
June 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29737740/-unilateral-sinonasal-disease-in-376-adult-patients-a-retrospective-study
#3
Xin Yan Cui, Li Qin Wang, Min Yin, Xi Chen, Mei Ping Lu, Han Zhou, Wei Da Dong, Zhi Bin Chen, Lei Cheng
OBJECTIVES: To investigate the clinical and pathological features of patients with unilateral sinonasal disease (USD). METHODS: A retrospective analysis was completed on 376 adult patients with USD from January 2015 to December 2016. Their presenting symptoms, nasal endoscope, CT scanning, and pathology were analyzed respectively. RESULTS: Among the 267 (71.01%) patients with inflammatory disease, there were 4 pathological types. And there were 8 pathological types in 60 (15...
March 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29731800/sinonasal-teratocarcinosarcoma-a-rare-tumour-not-so-rarely-misdiagnosed
#4
Jayalakshmy P Leelamma, Bhavya P Mohan, Aparna Srinivasan
Sinonasal teratocarcinosarcoma (STCS) is a rare, morphologically heterogeneous and highly aggressive tumour of ambiguous origin. It is characterized by the presence of benign and malignant epithelial, mesenchymal and neuroectodermal components. Because of their rarity and heterogeneity, these lesions are often misdiagnosed, leading to management difficulties. Adequate sampling with a high index of suspicion is needed to diagnose this rare tumour. We reported here a 48-year old man with right nasoethmoidal mass eroding the cribriform plate with intracranial extension...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29696477/imaging-features-of-benign-mass-lesions-in-the-nasal-cavity-and-paranasal-sinuses-according-to-the-2017-who-classification
#5
REVIEW
Hiroyuki Tatekawa, Taro Shimono, Masahiko Ohsawa, Satoshi Doishita, Shinichi Sakamoto, Yukio Miki
The World Health Organization (WHO) 2017 classification of head and neck tumors has been just published and has reorganized tumors of the nasal cavity and paranasal sinuses. In this classification, three new entities (seromucinous hamartoma, NUT carcinoma, and biphenotypic sinonasal sarcoma) were included, while the total number of tumors has been reduced by excluding tumors if they did not occur exclusively or predominantly in this region. Among these entities, benign tumors were classified as sinonasal papillomas, respiratory epithelial lesions, salivary gland tumors, benign soft tissue tumors, or other tumors...
April 25, 2018: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29685531/imaging-sinonasal-disease-with-mri-providing-insight-over-and-above-ct
#6
REVIEW
Geoiphy George Pulickal, Annakan V Navaratnam, Thi Nguyen, Alina Denisa Dragan, Magdalena Dziedzic, Ravi K Lingam
This article illustrates and discusses the applications and value of magnetic resonance imaging (MRI) in the evaluation of sinonasal disease. There are several clinical scenarios where MRI can add value over conventional computed tomography (CT) evaluation of the sinonasal spaces. Specifically, MRI can provide insight through better depiction of the anatomy of certain sinonasal sub-sites including the olfactory structures. It can aid in evaluating anosmia, sinusitis (fungal sinusitis and complications), benign and malignant lesions, CSF leaks and pathology extending into sinonasal spaces...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29666086/endonasal-endoscopic-laser-assisted-resection-of-septal-glomangiopericytoma
#7
Sana Sheikh, Fatima Sarwar, Naqeeb Ullah Khan, Muhammad Sarwar Khan
Glomangiopericytoma is a rare vascular neoplasm characterised by a pattern of prominent perivascular growth with myoid phenotype. It is categorised as a borderline low-malignancy tumour by WHO and accounts for less than 0.5% of all sinonasal tumours. After curative resection, patients of glomangiopericytoma need long-term endoscopic follow-up due to high risk of recurrence.We report a case of a 23-year-old man complaining of nasal obstruction off and on and frequent epistaxis. A reddish mass in the right nasal cavity was observed on endoscopy and treated with endoscopic excision...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29649994/bile-acids-at-neutral-and-acidic-ph-induce-apoptosis-and-gene-cleavages-in-nasopharyngeal-epithelial-cells-implications-in-chromosome-rearrangement
#8
Sang-Nee Tan, Sai-Peng Sim
BACKGROUND: Chronic rhinosinusitis (CRS) increases the risk of developing nasopharyngeal carcinoma (NPC) while nasopharyngeal reflux is known to be one of the major aetiological factors of CRS. Bile acid (BA), the component of gastric duodenal contents, has been recognised as a carcinogen. BA-induced apoptosis was suggested to be involved in human malignancies. Cells have the potential and tendency to survive apoptosis. However, cells that evade apoptosis upon erroneous DNA repair may carry chromosome rearrangements...
April 12, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29644904/survivin-and-cortactin-expression-in-sinonasal-schneiderian-inverted-papilloma-and-associated-carcinoma
#9
Gino Marioni, Giuseppe Brescia, Lorenzo Nicolè, Rosario Marchese-Ragona, Umberto Barion, Luciano Giacomelli, Filippo Marino, Alessandro Martini, Giancarlo Ottaviano
BACKGROUND: Sinonasal inverted (schneiderian) papilloma (IP) is histologically benign but shows a propensity for malignant transformation. Survivin, a member of the inhibitor of the apoptosis family of proteins that controls cell division, apoptosis, metastasis, and, probably, also neoangiogenesis, is overexpressed in essentially all human cancers. Overexpression of the multidomain protein cortactin has also been associated with increased cell migration, invasion, and metastatic potential in several malignancies...
March 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29644900/discordance-in-preoperative-and-postoperative-histopathology-of-sinonasal-tumors
#10
Ashwin Ganti, Bobby A Tajudeen, Max A Plitt, Isolina Rossi, Paolo Gattuso, Pete S Batra
Background Head and neck surgical pathology has been shown to be prone to histopathologic diagnostic error that can adversely impact patient care due to inappropriate management. Sinonasal tumors, in particular, present a diagnostic challenge given the relative rarity and diversity in histology and thus may have higher rates of discordant histology. Objective The purpose of this study is to determine the rate of discrepancy between preoperative and postoperative diagnoses of sinonasal tumors. Methods Retrospective chart review was performed on 52 patients treated for sinonasal tumors between January 2013 and December 2016...
March 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29625668/is-there-a-link-between-nasal-polyposis-and-increased-risk-for-sinonasal-malignancy
#11
Deena Pourang, Michael Batech, Kian Karimi, Javed Sheikh, Shefali Samant
No abstract text is available yet for this article.
April 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29607821/human-papilloma-virus-hpv-in-sinonasal-papillomas-and-squamous-cell-carcinomas-a-pcr-based-study-of-60-cases
#12
Ambreen Beigh, Ruby Rashi, Sheikh Junaid, Mehnaz Sultan Khuroo, Summyia Farook
This study was carried out to observe the association of Human Papilloma Virus (HPV) with papillomas and squamous cell carcinomas of the sinonasal region. The present study was a hospital-based study conducted over a period of three years from May, 2014 to May, 2017 in the Department of Pathology, Government Medical College, Srinagar. A total of 196 cases of non-neoplastic and neoplastic lesions of nasal cavity and paranasal sinuses were observed during the study period. Out of total 196 cases, 102 were non-neoplastic and 94 were neoplastic...
January 2018: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29594917/seromucinous-hamartoma-of-the-nasal-cavity
#13
Kimberly N Tong, Renee M Serra, Robert Y Shih, Robert D Foss
Seromucinous hamartoma (SMH) is a rare benign epithelial proliferation occurring in the sinonasal tract. The clinical, radiographic, and histologic appearance of SMH may mimic several benign and malignant entities. Presented is a novel case, with a review of the literature focused on potential histologic diagnostic pitfalls.
March 28, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29588301/leiomyosarcoma-a-rare-sinonasal-malignancy
#14
Matthew Ming Kei Kwok, Stewart Lee, Patrick Hosking
Leiomyosarcomas (LMS) are rare sinonasal malignant tumours with 20 cases of nasal LMS previously reported in the literature. An 81-year-old man presented with an incidental left nasal lesion associated with left nasal obstruction and occasional left-sided blood-stained rhinorrhoea. Nasendoscopic examination showed green coloured polyps filling the left nasal cavity with biopsies showing LMS. CT imaging did not show any bony erosion. No metastases were found on positron emission tomography imaging. The patient underwent endoscopic resection and all surgical margins were clear of disease...
March 27, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29581953/organized-hematoma-of-temporomandibular-joint
#15
Chena Lee, Jong In Yook, Sang-Sun Han
Organized hematoma is a pseudo-tumorous lesion mostly occurs at sinonasal cavity and often confused with malignant neoplasm. The initiation of this lesion is blood accumulation, probably due to trauma, and this hematoma develops into organized hematoma as it encapsulated with fibrous band and neo-vascularized. Since it is uninformed at temporomandibular joint (TMJ) region, imaging diagnosis might be challenging. Also, delayed detection of mass involving TMJ is not uncommon due to confusion with joint disorder...
March 2018: Imaging Science in Dentistry
https://www.readbyqxmd.com/read/29581706/treatment-outcomes-and-demographics-in-sinonasal-sarcoma-a-systematic-review-of-the-literature
#16
Mitchell R Gore
Background: Sarcomas comprise a diverse group of soft tissue mesenchymal malignancies. The sinuses and nasal region are a relatively rare site of sarcomas. Methods: Retrospective review of the literature on sinonasal sarcomas from 1987-2017. Data were analyzed for demographics, treatment type, stage, and histopathologic type. Kaplan-Meier analysis was used to assess and compare survival. Results: A total of 198 cases of sinonasal sarcoma were identified and analyzed...
2018: BMC Ear, Nose, and Throat Disorders
https://www.readbyqxmd.com/read/29581595/elevated-dna-methylation-in-malignant-tumors-of-the-sinonasal-tract-and-its-association-with-patient-survival
#17
Marcela Chmelarova, Jan Laco, Helena Kovarikova, Ivana Baranova, Pavel Dundr, Kristyna Nemejcova, Jaroslav Michalek, Milan Vosmik, Vladimir Palicka
BACKGROUND: Epigenetic modifications have been recognized as an important mechanism underlying carcinoma progression. DNA methylation plays an important role in cancer biology and represents potentially heritable changes in gene expression that do not involve DNA sequence. The aim of this study was to investigate promoter methylation of selected genes in sinonasal carcinoma by comparison with noncancerous sinonasal tissue. METHODS: To search for epigenetic events (methylation in 25 tumor suppressor genes) we used MS-MLPA (Methylation-specific multiplex ligation-dependent probe amplification) to compare methylation status of 59 formalin fixed, paraffin embedded tissue samples of sinonasal carcinomas with 18 control samples...
March 27, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29578367/incidence-and-survival-in-sinonasal-carcinoma-a-danish-population-based-nationwide-study-from-1980-to-2014
#18
Sannia Sjöstedt, David Hebbelstrup Jensen, Kathrine Kronberg Jakobsen, Christian Grønhøj, Charlotte Geneser, Kirstine Karnov, Lena Specht, Tina Klitmøller Agander, Christian von Buchwald
BACKGROUND: Sinonasal cancers are rare and comprise <1% of all malignancies. This study describes incidence and survival in sinonasal carcinomas in Denmark from 1980 to 2014. METHODS: All patients registered in the Danish Cancer Registry in the period were included. Age-adjusted incidence rate, average annual percentage change, and relative survival were calculated. Age-period-cohort models were constructed. RESULTS: 1,720 patients with sinonasal carcinoma (median age 67 years, 63% males) were identified...
March 26, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29554067/osteosarcoma-of-the-ethmoid-sinus
#19
Zülküf Burak Erdur, Emine Deniz Gözen, Hakki Caner Inan, Haydar Murat Yener, Nil Çomunoğlu, Cansu Yol, Çiğdem Papila, Harun Cansiz
Osteosarcoma (OS) is a malignant bone tumor and it is very rare in head and neck region. If it arises in this area, most common localizations of this tumor are mandible and maxilla and ethmoid sinus is very rare site for this malignancy. A 43-year-old female admitted to our clinic with the complaint of pain in the right half of the face and headache persisting for 2 months. According to the clinical symptoms and imaging studies, sinonasal ossifying fibroma was suspected. For this reason, patient was operated endoscopically and histopathological examination revealed that osteoid matrix producing atypical osteoblastic cells so these findings identified osteoblastic variant OS...
March 16, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29548524/clinical-features-of-nasal-and-sinonasal-inverted-papilloma-associated-with-malignancy
#20
Takuya Miyazaki, Yasuharu Haku, Akira Yoshizawa, Ken Iwanaga, Takashi Fujiwara, Masanobu Mizuta, Atsuhiro Yoshida, Shinichi Satou, Hisanobu Tamaki
OBJECTIVE: Nasal and sinonasal inverted papilloma (IP) are rare benign tumors and have the potential to exhibit malignancy in approximately 10% of cases. This study aimed to analyze the clinical features of IP associated with malignancy. Furthermore, we reviewed our therapeutic strategy and the clinical course of malignant IP. METHODS: Overall, 70 patients with IP at our institution were retrospectively analyzed from April 2006 to December 2015; of these, six (9%) had associated malignancy...
March 13, 2018: Auris, Nasus, Larynx
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