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Sinonasal malignancy

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https://www.readbyqxmd.com/read/28815617/disparities-in-sinonasal-squamous-cell-carcinoma-short-and-long-term-outcomes-analysis-from-the-national-cancer-database
#1
Ryan M Carey, Arjun K Parasher, Alan D Workman, Carol H Yan, Jordan T Glicksman, Jinbo Chen, James N Palmer, Nithin D Adappa, Jason G Newman, Jason A Brant
OBJECTIVES/HYPOTHESIS: To examine sociodemographic, hospital-specific, and disease-related characteristics in relation to outcomes in sinonasal squamous cell carcinoma (SCC). STUDY DESIGN: The National Cancer Database was queried for location codes corresponding to the nasal cavity and paranasal sinuses and histology codes representing SCC malignancy. Multivariate analyses were performed against short- and long-term outcomes (overall survival, days to discharge, 30-day readmission, and 30- and 90-day mortality)...
August 16, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28809123/-18-fdg-pet-ct-in-routine-surveillance-of-asymptomatic-patients-following-treatment-of-sinonasal-neoplasms
#2
Alan D Workman, Jordan T Glicksman, Arjun K Parasher, Ryan M Carey, Steven G Brooks, David W Kennedy, Seyed A Nabavizadeh, Kim O Learned, James N Palmer, Nithin D Adappa
Objective Sinonasal neoplasms have a high rate of recurrence following treatment, and current guidelines support the use of a variety of surveillance techniques. Recent work demonstrates that performance parameters of surveillance modalities may differ with sinonasal tumors in particular when compared with head and neck tumors overall. This study aims to characterize the value of (18)fluorodeoxyglucose ((18)FDG) positron emission tomography/computed tomography (PET/CT) as a screening tool in asymptomatic patients...
August 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28799187/safety-evaluation-of-combination-carboplatin-and-toceranib-phosphate-palladia-in-tumour-bearing-dogs-a-phase-i-dose-finding-study
#3
R M Wouda, S E Hocker, M L Higginbotham
Combining conventional cytotoxic maximum tolerated dose (MTD) chemotherapy with low-dose metronomic and/or anti-angiogenic agents is a exciting area of oncologic research. The objective of this study was to establish the MTD, safety and adverse event (AE) profile of 1 such drug combination. This prospective phase I dose-finding clinical trial assumed an open-label 3 + 3 cohort design. Client-owned dogs with 1 or more cytologically and/or histologically confirmed and macroscopically measurable, naive or recurrent, malignant tumours, were enrolled...
August 10, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28798001/giant-primary-sinonasal-mucosal-melanoma-a-rare-malignancy
#4
Mehtab Alam, Mohd Aslam, Piyush Kant Singh, Shahab Farkhund Hashmi, Syed Abrar Hasan
It is extremely rare to find a case of primary sinonasal mucosal melanoma, which is more aggressive and have poorer outcome than its cutaneous counterpart. This tumour is refractory to the treatment which includes wide surgical excision with or without adjuvant postoperative radiotherapy. We are reporting a case of 60 year old female who presented with right sided nasal mass and facial deformity, in whom the diagnosis of mucosal melanoma was made on histopathological examination and confirmed by immunohistochemistry...
May 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28775129/comprehensive-molecular-profiling-of-olfactory-neuroblastoma-identifies-potentially-targetable-fgfr3-amplifications
#5
Lorena Lazo de la Vega, Jonathan B McHugh, Andi K Cani, Komal Kunder, Frances M Walocko, Chia-Jen Liu, Daniel H Hovelson, Dan R Robinson, Arul M Chinnaiyan, Scott A Tomlins, Paul W Harms
Olfactory neuroblastomas (ONBs), also known as esthesioneuroblastomas, are malignant round-cell tumors that represent up to 5% of sinonasal malignancies. Despite their aggressive course, molecular studies of ONBs have been limited, and targeted therapies are lacking. To identify potential oncogenic drivers and targetable pathways in ONBs, we characterized 20 ONBs, including archived ONBs profiled by targeted, multiplexed PCR (mxPCR) based DNA next generation sequencing (NGS) of the coding sequence of over 400 cancer-relevant genes (n=16), mxPCR based RNA NGS of 108 target genes (n=15), and two ONBs profiled by comprehensive hybrid-capture based clinical grade NGS of >1,500 genes...
August 3, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28767609/sinonasal-renal-cell-like-adenocarcinoma-a-unique-variant-of-primary-clear-cell-carcinoma-of-the-head-and-neck-the-first-reported-case-in-korea
#6
Nah-Ihm Kim, Jung-In Yang, Sung-Sun Kim, Ji-Shin Lee, Sang-Chul Lim, Shin Jung, Jae-Hyuk Lee, Kyung-Sub Moon, Kyung-Hwa Lee
RATIONALE: Primary sinonasal renal cell-like adenocarcinoma (SNRCLA) is a rare and unique neoplasm. PATIENT CONCERNS: A 63-year-old man presented with repeated epistaxis, nasal obstruction and hyposmia of 2-month duration. Radiological studies revealed a mass of the left ethmoid sinus involving anterior skull base. DIAGNOSIS: The patient was treated with craniofacial resection, bifrontal craniotomy combined with an endonasal endoscopic approach...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28740564/can-diffusion-weighted-imaging-aid-in-differentiating-benign-from-malignant-sinonasal-masses-a-useful-adjunct
#7
Abanti Das, Ashu S Bhalla, Raju Sharma, Atin Kumar, Alok Thakar, Sreenivas M Vishnubhatla, Mehar C Sharma, Suresh C Sharma
BACKGROUND: To evaluate the role of diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) values at 3 Tesla in characterizing sinonasal masses. MATERIAL/METHODS: After ethical clearance, 79 treatment naive patients with head and neck masses underwent magnetic resonance imaging (MRI), including DWI at 3 Tesla using the following b values - 0, 500 and 1000 s/mm(2). Thirty-one patients were found to have sinonasal tumours and were subsequently analysed...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28734993/esthetically-favorable-surgical-alternative-for-the-removal-of-sinonasal-malignant-tumors-the-modified-facial-degloving-technique
#8
REVIEW
Gábor Vass, Zsolt Bella, Zoltán Tóbiás, Attila Nagy, László Iván, László Rovó
PURPOSE: The widely used external approach (Weber-Fergusson incision) for the removal of maxillary ethmoid tumors leaves stigmatizing scars and deformities on the patient's face. As an alternative technique, the scarless facial degloving approach was first described in the 1970s; since then, several modifications have been developed. PATIENTS AND METHODS: The authors have been using a modified facial degloving technique for 7 years to remove maxillary ethmoid tumors...
June 29, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28725520/mucosal-thickening-occurs-in-contralateral-paranasal-sinuses-following-sinonasal-malignancy-treatment
#9
Alice Z Maxfield, Kyle J Chambers, Ahmad R Sedaghat, Derrick T Lin, Stacey T Gray
Objective  To investigate the incidence and degree of contralateral sinus disease following treatment of sinonasal malignancy (SNM) using radiological findings as an outcome measure. Study Design  Retrospective case series. Setting  Tertiary referral academic center. Participants  Patients with SNM treated with surgical and adjuvant radiotherapy with or without concurrent chemotherapy. Main Outcome Measures  Pre- and posttreatment computed tomography and magnetic resonance imaging scans, Lund-Mackay (LM) score, date of diagnosis, chemotherapy, and dosage of radiation therapy (RT)...
August 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28717528/the-relationship-between-werner-syndrome-and-sinonasal-malignant-melanoma-two-sibling-cases-of-werner-syndrome-with-malignant-melanoma
#10
Yoshinori Kadowaki, Satoru Kodama, Munehito Moriyama, Masashi Suzuki
Werner syndrome (WS) is an autosomal recessive disease characterized by premature aging. Malignant tumors such as thyroid carcinoma and malignant melanoma occur frequently in WS patients. We describe 2 siblings with WS who suffered from sinonasal malignant melanoma (MM). Both patients initially experienced nasal obstruction and recurrent nasal bleeding and died within 2 years of the diagnosis of MM. Otolaryngologists should recognize that WS patients have a high risk for head and neck malignant disease, particularly sinonasal MM, even if they are aged below the expected age range and undergo periodic examinations...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28716213/imaging-of-endoscopic-approaches-to-the-anterior-and-central-skull-base
#11
REVIEW
I M Schmalfuss
Sinonasal endoscopy for treatment of benign sinonasal diseases is a well-established procedure. Recent advances in endoscope technology have substantially expanded its application with many institutions now offering resection of skull base lesions and sinonasal malignancies via the endoscopic approach. Its minimally invasive nature leads to faster recovery time, better cosmetic results, and fewer complications. Unfortunately, not all lesions involving the sinonasal region and skull base are accessible to sinonasal endoscopy...
July 14, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28707783/aggressive-necrotizing-pseudomonal-sinonasal-infections
#12
Edward C Kuan, Bobby A Tajudeen, Kevin C Welch, Rakesh K Chandra, Ben J Glasgow, Jeffrey D Suh
BACKGROUND: Pseudomonas aeruginosa is a gram-negative bacterium frequently implicated in recalcitrant sinonasal infections, especially in immunocompromised hosts. We report 6 cases of rapidly progressive pseudomonal acute rhinosinusitis producing tissue necrosis and, in certain cases, cranial nerve palsies. METHODS: Retrospective review of 6 patients with aggressive necrotizing sinonasal infections treated at 4 tertiary academic medical centers with sinonasal cultures growing P...
July 14, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28693263/role-of-microrna-296-3p-in-the-malignant-transformation-of-sinonasal-inverted-papilloma
#13
Tomohiko Kakizaki, Hiromitsu Hatakeyama, Yuji Nakamaru, Dai Takagi, Takatsugu Mizumachi, Tomohiro Sakashita, Satoshi Kano, Akihiro Homma, Satoshi Fukuda
Inverted papilloma (IP) is a benign tumor occurring in the nasal cavity and paranasal sinuses. It is reported that 5-15% of IPs undergo malignant transformation into squamous cell carcinoma (SCC), and the role of microRNAs (miRNA/miR) in this process remains to be elucidated. In the present study, whole miRNA profiles using samples of IP and SCC were investigated, in order to detect the function of miRNA in the carcinogenesis of IP. Samples from IPs (n=5) and SCC lesions (n=5), which arose from IPs, were used for miRNA analysis...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28689974/endoscopic-surgery-for-sinonasal-tumors-the-transcribriform-approach
#14
R Thomas, P Martin, D Patrick, M Justin
Over the past 10 to 20 years, endoscopic endonasal surgery has become for many teams the preferred treatment for sinonasal tumors. Technical advances in the field of surgical instrumentation (good visualization, hemostasis…) and the progress of imaging guidance (to avoid neurovascular complication) has made those procedures simpler and safer. Nevertheless, endonasal endoscopic procedures require a trained surgical team of ENT specialist and neurosurgeon. Endoscopic endonasal surgery has been reported to be feasible for all types of sinonasal tumors whether benign tumors such as inverted papillomas, or malignant tumors...
July 8, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28675112/the-relationship-of-paranasal-sinus-opacification-to-hospital-acquired-pneumonia-in-the-neurologic-intensive-care-unit-patient
#15
Phillip Huyett, Nicholas R Rowan, Berrylin J Ferguson, Stella Lee, Eric W Wang
BACKGROUND: The association between intensive care unit (ICU) sinusitis and the development of lower airway infections remains unclear. The objective of this study was to determine the correlation between the development of radiographic sinus opacification and pneumonia in the neurologic ICU setting. METHODS: A retrospective review of head computed tomography or magnetic resonance imaging of 612 patients admitted to the neurocritical care unit at a tertiary care center from April 2013 through April 2014 was performed...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28669305/association-between-nasal-obstruction-and-risk-of-depression-in-chronic-rhinosinusitis
#16
Katie M Phillips, Lloyd P Hoehle, Regan W Bergmark, Adam P Campbell, David S Caradonna, Stacey T Gray, Ahmad R Sedaghat
Objective Chronic rhinosinusitis (CRS) is associated with an increased risk for depression. Since nasal obstruction is a symptom of CRS that is treatable, we sought to characterize its impact on the risk for depression in CRS. Study Design Prospective cross-sectional cohort of 94 patients with CRS. Setting Academic tertiary care rhinology clinic. Subjects and Methods Patients with CRS without vasculitis, cystic fibrosis, sarcoidosis, immunodeficiency, or sinonasal malignancy. Risk for depression was assessed with the 2-item Patient Health Questionnaire (PHQ-2) while nasal obstruction was assessed with the Nasal Obstruction Symptom Evaluation (NOSE) instrument...
July 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28646364/sinonasal-malignancies-incidence-and-histological-distribution-in-jamaica-1973-2007
#17
Tracey N Gibson, Dawn P McNaughton, Barrie Hanchard
PURPOSE: To determine the histological distribution and trends in incidence of sinonasal malignancies in Jamaica. METHODS: Cases of all sinonasal malignancies diagnosed between 1973 and 2007 were extracted from the archives of the Jamaica Cancer Registry. Data recorded for each case included age at diagnosis, sex, year of diagnosis, topography, and histology. Data were used to calculate frequencies, age-specific incidence rates, and age-standardized incidence rates (ASRs)...
June 23, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28644571/difference-between-respiratory-epithelial-adenomatoid-hamartomas-and-small-malignant-tumors-of-the-olfactory-cleft-on-ct-scans-in-forty-six-patients
#18
Théophile De Saint Hilaire, Cécile Rumeau, Patrice Gallet, Phi-Linh Nguyen-Thi, Roger Jankowski, Duc Trung Nguyen
Misdiagnosis of respiratory epithelial adenomatoid hamartomas for malignant tumors can lead to an aggressive surgical procedure, which is not necessary in the case of a respiratory epithelial adenomatoid hamartoma. Detailed analysis of sinonasal CT scans without contrast can help to distinguish respiratory epithelial adenomatoid hamartomas of the olfactory cleft from small malignant tumors (T1 and T2) of the olfactory clefts. Criteria in favor of diagnosis of small malignant tumors of the olfactory clefts on CT scans without contrast were unilaterality of masses in the olfactory clefts, large olfactory clefts /small olfactory clefts ratio ≥ 2 (sensibility at 91% and specificity at 100%), and presence of bone erosion...
June 23, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28637513/sinonasal-teratocarcinosarcoma-a-case-report
#19
Yi Chao Foong, Vince Murdolo, Nusa Naiman, Laura Hepner, Raef Awad
BACKGROUND: Sinonasal teratocarcinosarcoma is a rare and aggressive malignancy with histological features of both carcinosarcoma and teratoma. The optimal management of this malignancy is unclear, with most patients being managed by a combination of surgery and radiotherapy. CASE PRESENTATION: We describe an 83-year-old white woman with sinonasal teratocarcinosarcoma of her left nasal cavity treated with surgical debulking initially with radiological evidence of residual disease which was treated with radiotherapy (60 Gy in 30 fractions)...
June 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28635991/the-papillomas-of-the-sinonasal-tract-a-comprehensive-review
#20
G Leoncini, L Zanetti
Papillomas are uncommon tumors of the sinonasal tract histologically derived from the Schneiderian membrane. Three distinctive variants are described, the exophytic, the inverting and the oncocytic types. On physical examination, their appearance varies from exophytic-fungiform seen in the exophytic variant, to polypoid-papillary in both the inverting and oncocytic variant. The presence of an asymptomatic mass or epistaxis and unilateral nasal obstruction are the typical presenting symptoms. Clinically they tend to recur and, although benign, they may erode the bone laminas by pressure, especially the inverting type, causing proptosis and other co-morbidities...
March 2017: Pathologica
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