Se-Eun Kim, Ho-Sung Jeon, Tae-Hwa Go, Jung-Hee Lee, Jun-Won Lee, Young Jin Youn, Byeong-Keuk Kim, Hyung Joon Joo, Do-Sun Lim, Kiyuk Chang, Yongwhi Park, Young Bin Song, Jung-Won Suh, Sang Yeob Lee, Jung Rae Cho, Ae-Young Her, Hyo-Soo Kim, Moo Hyun Kim, Eun-Seok Shin, Diana A Gorog, Udaya S Tantry, Paul A Gurbel, Young-Hoon Jeong, Sung Gyun Ahn
Loss-of-function (LoF) alleles of cytochrome P450 2C19 (CYP2C19), which are prevalent in East Asians, are linked to high platelet reactivity (HPR) phenotype and poor prognosis. We aimed to investigate the incremental predictive value of HPR combined with CYP2C19 genotype in predicting outcomes after drug-eluting stent (DES) implantation. The PTRG-DES (Platelet function and genotype-related long-term proGnosis in Drug-Eluting Stent-treated patients) consortium enrolled a total of 13,160 Korean patients treated with DES who had platelet function test (PFT) or CYP2C19 genotype, of which, 6717 patients with PTF and genotype together were categorized...
August 19, 2023: Clinical Pharmacology and Therapeutics