keyword
https://read.qxmd.com/read/38463677/prognostic-implication-of-platelet%C3%A2-reactivity-according-to-procedural-complexity-after-pci-subanalysis-of-ptrg-des-consortium
#1
JOURNAL ARTICLE
Xuan Jin, Young-Hoon Jeong, Kwang Min Lee, Sung Cheol Yun, Byeong-Keuk Kim, Hyung Joon Joo, Kiyuk Chang, Yong Whi Park, Young Bin Song, Sung Gyun Ahn, Jung-Won Suh, Sang Yeub Lee, Jung Rae Cho, Ae-Young Her, Hyo-Soo Kim, Do-Sun Lim, Eun-Seok Shin, Moo Hyun Kim
BACKGROUND: Complex percutaneous coronary intervention (C-PCI) and high platelet reactivity (HPR) have been proposed as representative risk factors for the high ischemic phenotype. Uncertainty remains regarding the relative prognostic importance of these factors. OBJECTIVES: This study aimed to investigate the prognostic implication of HPR according to procedural complexity. METHODS: Patients treated with drug-eluting stent implantation (PTRG-PFT cohort; N = 11,714) were classified according to procedural complexity...
March 2024: JACC Asia
https://read.qxmd.com/read/38439661/platelet-function-testing-to-guide-cangrelor-dosing-in-patients-with-temporary-mechanical-circulatory-support-or-as-a-bridge-to-procedure
#2
JOURNAL ARTICLE
Margaret M Buck, Chelsea I Barry, Courtney A Montepara, Nathan J Verlinden
Cangrelor is a rapid-acting, intravenous P2Y12 inhibitor that can be used in patients after percutaneous coronary intervention who require mechanical circulatory support or as a bridge to procedure. We retrospectively reviewed adult patients who received platelet function testing (PFT) with the VerifyNow P2Y12 assay while on cangrelor from March 2021 through November 2022. All patients were initiated on 0.75 mcg/kg/min of cangrelor with P2Y12 reaction unit (PRU) values collected 12-24 h after initiation...
2024: Clinical and Applied Thrombosis/hemostasis
https://read.qxmd.com/read/38419600/cangrelor-in-contemporary-patients-with-st-segment-elevation-myocardial-infarction-pretreated-with-ticagrelor-pharmacodynamic-data-from-the-pompeii-study
#3
JOURNAL ARTICLE
Giuseppe Gargiulo, Plinio Cirillo, Luca Sperandeo, Imma Forzano, Domenico Simone Castiello, Domenico Florimonte, Fiorenzo Simonetti, Roberta Paolillo, Lina Manzi, Alessandra Spinelli, Carmen Anna Maria Spaccarotella, Raffaele Piccolo, Luigi Di Serafino, Anna Franzone, Piera Capranzano, Marco Valgimigli, Giovanni Esposito
BACKGROUND: There are limited data to assess pharmacodynamic (PD) profiles of patients with STEMI undergoing primary percutaneous coronary intervention (PCI) and receiving cangrelor after pretreatment with ticagrelor. METHODS: The PharmacOdynaMic effects of cangrelor in PatiEnts wIth acute or chronIc coronary syndrome undergoing percutaneous coronary intervention (POMPEII) registry (NCT04790032) is a prospective study conducted at Federico II University of Naples enrolling all patients undergoing PCI receiving cangrelor at operator's discretion...
February 2024: IJC Heart & Vasculature
https://read.qxmd.com/read/38335531/antithrombotic-stewardship-evaluation-of-platelet-reactivity-guided-cangrelor-dosing-using-the-verifynow%C3%A2-assay
#4
JOURNAL ARTICLE
Alexander Connery, Tania Ahuja, Alyson Katz, Serena Arnouk, Eric Zhu, John Papadopoulos, Sunil Rao, Cristian Merchan
Cangrelor may be used as a bridge when temporary interruption of dual antiplatelet therapy (DAPT) is necessary. However, the optimal dose and monitoring of cangrelor in patients remains unknown, especially in the setting of mechanical circulatory support (MCS). We conducted an observational, single-center, retrospective cohort study of patients that had PCI within 3 months and received cangrelor while admitted to any intensive care unit. The primary outcome was the incidence of any major adverse cardiovascular event (MACE)...
February 8, 2024: Journal of Cardiovascular Pharmacology
https://read.qxmd.com/read/38258362/prognostic-implication-of-platelet-reactivity-according-to-left-ventricular-systolic-dysfunction-status-in-patients-treated-with-drug-eluting-stent-implantation-analysis-of-the-ptrg-des-consortium
#5
MULTICENTER STUDY
Donghoon Han, Sun-Hwa Kim, Dong Geum Shin, Min-Kyung Kang, Seonghoon Choi, Namho Lee, Byeong-Keuk Kim, Hyung Joon Joo, Kiyuk Chang, Yongwhi Park, Young Bin Song, Sung Gyun Ahn, Jung-Won Suh, Sang Yeub Lee, Ae-Young Her, Young-Hoon Jeong, Hyo-Soo Kim, Moo Hyun Kim, Do-Sun Lim, Eun-Seok Shin, Jung Rae Cho
BACKGROUND: Coronary artery disease patients undergoing percutaneous coronary intervention (PCI) often exhibit reduced left ventricular ejection fraction (LVEF). However, the impact of LV dysfunction status in conjunction with platelet reactivity on clinical outcomes has not been previously investigated. METHODS: From the multicenter PTRG-DES (Platelet function and genoType-Related long-term prognosis in DES-treated patients) consortium, the patients were classified as preserved-EF (PEF: LVEF ≥ 50%) and reduced-EF (REF: LVEF< 5 0%) group by echocardiography...
January 22, 2024: Journal of Korean Medical Science
https://read.qxmd.com/read/38241058/platelet-reactivity-and-activated-clotting-time-predict-hemorrhagic-site-complications-in-patients-with-chronic-coronary-syndromes-undergoing-percutaneous-coronary-interventions
#6
JOURNAL ARTICLE
Bogumił Ramotowski, Paweł Lewandowski, Tomasz Słomski, Paweł Maciejewski, Andrzej Budaj
BACKGROUND: Radial access is preferred in patients with chronic coronary syndromes (CCSs) treated with ad hoc percutaneous coronary intervention (PCI). Antithrombotic and antiplatelet treatment before PCI may affect outcomes at vascular access sites. QuikClot Radial is a kaolin-based band that may shorten hemostasis time. Using point-of-care testing, we investigated the effect of antithrombotic and antiplatelet treatment on access-site complications. METHODS: This prospective observational study included consecutive patients with CCS on chronic aspirin therapy referred for ad hoc PCI...
January 22, 2024: Coronary Artery Disease
https://read.qxmd.com/read/38192126/assessing-the-efficacy-of-verifynow-platelet-function-testing-in-predicting-postoperative-hemorrhagic-complications-of-neuroendovascular-surgery-a-systematic-review-and-meta-analysis-part-2
#7
REVIEW
Devon L Mitchell, Laura Stone McGuire, Syed I Khalid, Ali Alaraj
BACKGROUND: Dual antiplatelet therapy is used to reduce the risk of thromboembolic complications in neuroendovascular surgery. However, the predictive utility of preoperative platelet-sensitivity testing for decreasing bleed risk in patients undergoing endovascular neurointervention remains unclear. OBJECTIVE: We conducted a systematic review and meta-analysis to illustrate the association between platelet response and risk of hemorrhagic complications from neuroendovascular surgery, examine the efficacy of the VerifyNow platelet reactivity unit (PRU) assay in predicting hemorrhagic outcomes, and assess whether a clinically useful threshold for platelet response can be defined to standardize guidelines...
January 8, 2024: Interventional Neuroradiology
https://read.qxmd.com/read/38186294/assessing-the-efficacy-of-verifynow-platelet-function-testing-in-predicting-postoperative-thromboembolic-complications-of-neuroendovascular-surgery-a-systematic-review-and-meta-analysis-part-1
#8
REVIEW
Devon L Mitchell, Laura Stone McGuire, Syed I Khalid, Ali Alaraj
BACKGROUND: Despite the heavily debated use of routine platelet-function testing, the VerifyNow Platelet Reactivity Unit (PRU) assay has been increasingly adopted as standard of care for assessing risk of postoperative thromboembolic complications of neuroendovascular surgery. OBJECTIVE: We conducted a systematic review and meta-analysis to examine the relationship between platelet response and risk of ischemic events from neuroendovascular surgery, assess the efficacy of point-of-care platelet-function testing in predicting thromboembolic outcomes, and assess whether a clinically useful threshold for platelet response can be defined in order to standardize guidelines...
January 8, 2024: Interventional Neuroradiology
https://read.qxmd.com/read/38166614/utility-of-verifynow-to-assess-the-immediate-pharmacodynamic-response-of-chewed-and-swallowed-aspirin-comparison-with-aggregometry
#9
JOURNAL ARTICLE
Kevin P Bliden, Parshotam Kundan, Danielle Kraft, Rueshil Parekh, Sahib Singh, Aravind D Babu, Anika P Shah, Udaya S Tantry, Paul A Gurbel
VerifyNow (VN) test is a less laborious method to assess pharmacodynamics (PD) compared to light transmittance aggregometry (LTA). VN assay has not been used to study the immediate PD effects of acetylsalicylic acid (ASA). Ten healthy volunteers were randomly assigned to a single 162 or 650 mg dose of chewed and swallowed ASA. Pharmacodynamic and pharmacokinetic measurements were performed at baseline and serially up to 60 min after ASA administration. Onset by VN was 20 ± 7 min with 162 mg and 13 ± 7 min with 650 mg ASA ( p  = ...
December 2024: Platelets
https://read.qxmd.com/read/38153548/analysis-of-platelet-function-testing-in-children-receiving-aspirin-for-antiplatelet-effects
#10
JOURNAL ARTICLE
David M Newland, Michelle M Palmer, Lisa R Knorr, Jennifer L Pak, Erin L Albers, Joshua M Friedland-Little, Borah J Hong, Yuk M Law, Kathryn L Spencer, Mariska S Kemna
Aspirin (ASA) remains the most common antiplatelet agent used in children. VerifyNow Aspirin Test® (VN) assesses platelet response to ASA, with therapeutic effect defined by the manufacturer as ≤ 549 aspirin reaction units (ARU). Single-center, observational, analysis of 195 children (< 18 years-old) who underwent first VN between 2015 and 2020. Primary outcome was proportion of patients with ASA biochemical resistance (> 549 ARU). Secondary outcomes included incidence of new clinical thrombotic and bleeding events during ≤ 6 months from VN in those who received ASA monotherapy (n = 113)...
December 28, 2023: Pediatric Cardiology
https://read.qxmd.com/read/38122860/platelet-function-testing-and-clinical-outcomes-in-peripheral-arterial-disease-systematic-review-and-narrative-synthesis
#11
REVIEW
Aman Kankaria, Monica Majumdar, Sonia Lee, Ryan P Hall, Sasha P Suarez Ferreira, Ivy Lee, Shiv S Patel, Samuel Jessula, Mario D'Oria, Anahita Dua
OBJECTIVE: This systematic review aims to comprehensively assess the contemporary literature on platelet function testing (PFT) in individuals undergoing revascularization therapy for peripheral arterial disease (PAD). The goal is to identify whether PFT can aid in detecting antiplatelet resistance, predicting post-procedural thrombotic complications, and informing tailored treatment strategies. METHODS: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a literature review was conducted using PubMed databases...
December 18, 2023: Journal of Vascular Surgery
https://read.qxmd.com/read/38082549/periprocedural-antiplatelet-medication-assessed-by-verifynow-for-neuroendovascular-treatment-comparison-of-prasugrel-with-clopidogrel
#12
JOURNAL ARTICLE
Kosuke Nambu, Kouichi Misaki, Takehiro Uno, Taishi Tsutsui, Tomoya Kamide, Mitsutoshi Nakada
OBJECTIVE: The maintenance dose of prasugrel (PRAS) for neuroendovascular treatment requires much research. We report the antiplatelet effect of PRAS measured by VerifyNow P2Y12 reaction units (PRUs) in patients during the perioperative period of neuroendovascular treatment. METHODS: Between January 2017 and January 2023, 230 patients who underwent endovascular treatment for unruptured intracranial aneurysms or carotid artery stenosis at our institution were retrospectively identified...
December 11, 2023: Interventional Neuroradiology
https://read.qxmd.com/read/38066385/early-assessment-of-the-pharmacokinetic-and-pharmacodynamic-effects-following-acetylsalicylic-acid-loading-toward-a-definition-for-acute-therapeutic-response
#13
JOURNAL ARTICLE
Paul A Gurbel, Kevin P Bliden, Parshotam Kundan, Danielle Kraft, Rueshil Parekh, Sahib Singh, Aravind D Babu, Anika P Shah, Rahul Chaudhary, Udaya S Tantry
Despite decades of investigations, the optimal assessment of the "therapeutic response" to early after loading dose of acetylsalicylic acid (ASA) remains unclear. Limited information is available on the relation between pharmacodynamic (PD) and pharmacokinetic (PK) measurements assessed immediately after ASA administration. Serial PD and PK analyses were performed immediately after a single 162 or 650 mg dose of chewed and swallowed ASA in ten healthy adults. ASA response was defined as > 95% inhibition of serum thromboxane (Tx)B2,  < 550 aspirin reaction units (ARU) by VerifyNow Aspirin (VN) test, and ≤ 20% arachidonic acid (AA)-induced platelet aggregation (PA)...
December 8, 2023: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38031444/safety-of-dual-antiplatelet-therapy-using-aspirin-and-low-dose-prasugrel-with-platelet-reactivity-testing-in-flow-diverter-treatment-of-intracranial-aneurysms
#14
JOURNAL ARTICLE
Liam M Flynn, Ezaz Mohamed, Nicholas Dobbs, Alberto Nania, Johannes Du Plessis, Peter M Keston, Jonny J Downer
BACKGROUND: Dual antiplatelet therapy (DAPT) is standard care for intracranial stenting to prevent thrombotic complications. Clopidogrel resistance has resulted in patients receiving newer P2Y12 inhibitors like Prasugrel, which may reduce thrombotic complications but could increase haemorrhagic complications. This study, utilising platelet reactivity testing, compared thrombotic and haemorrhagic complications associated with Clopidogrel or 20 mg Prasugrel loading in patients treated with flow diverters (FD) for intracranial aneurysms...
November 29, 2023: Interventional Neuroradiology
https://read.qxmd.com/read/38025153/novel-dosing-and-monitoring-of-aspirin-in-infants-with-systemic-to-pulmonary-artery-shunt-physiology-the-soprano-study
#15
JOURNAL ARTICLE
Joshua W Branstetter, Gary Woods, Hania Zaki, Nicole Coolidge, Tawanda Zinyandu, Subhadra Shashidharan, Alaa Aljiffry
OBJECTIVES: Provision of pulmonary blood flow with a systemic-to-pulmonary artery shunt is essential in some patients with cyanotic congenital heart disease. Traditionally, aspirin (ASA) has been used to prevent thrombosis. We evaluated ASA dosing with 2 separate antiplatelet monitoring tests for accuracy and reliability. METHODS: This is a retrospective, pre-post intervention single center study. Two cohorts were evaluated; the pre-intervention group used thromboelastography platelet mapping (TPM) and post-intervention used VerifyNow aspirin reactivity unit (ARU) monitoring...
2023: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/37812922/clopidogrel-related-high-residual-platelet-reactivity-associated-with-estimated-glomerular-filtration-rate-in-patients-with-acute-ischemic-stroke
#16
JOURNAL ARTICLE
Yongkang Zhang, Yuan Zong, Jiarui Liu, Kangli Yin, Yuzhen Wang, Yuefeng Bian, Yichen Huang, Wei Liu, Yemin Cao
INTRODUCTION: There are few studies on the relationship between the occurrence of clopidogrel-related high residual platelet reactivity (HRPR) and estimated glomerular filtration rate (eGFR) at admission in patients with ischemic stroke. The aim of this study was to investigate the possible relationship between the two. METHODS: Patients who were hospitalized and diagnosed with acute ischemic stroke were recruited from 1 July 2017 to 30 June 2018 at Shanghai TCM-Integrated Hospital...
October 9, 2023: Cerebrovascular Diseases Extra
https://read.qxmd.com/read/37775345/evaluation-of-cangrelor-use-after-percutaneous-coronary-intervention-in-patients-with-mechanical-circulatory-support
#17
JOURNAL ARTICLE
Jack C Pluenneke, Adham M Mohamed, Charles H Hayes, Timothy P Berry, Elizabeth L Thomas, Larisa Zhurav, Jonathan B Kozinn, Michelle M Haines, Julie A Welge
OBJECTIVES: To describe cangrelor use in patients on concurrent mechanical circulatory support who underwent postpercutaneous coronary intervention. DESIGN: A single-center, retrospective, cohort study. SETTING: At a quaternary teaching hospital. PARTICIPANTS: Included patients were ≥18 years old, admitted to the intensive care unit, underwent percutaneous coronary intervention with stent placement, initiated on mechanical circulatory support, and received cangrelor in the postpercutaneous coronary intervention period...
September 6, 2023: Journal of Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/37740121/differential-inhibition-of-platelet-function-by-cilostazol-in-combination-with-clopidogrel
#18
JOURNAL ARTICLE
Masako Yamazaki, Yuka Shirai, Tomoko Ohnishi, Kazuya Hosokawa, Jeffrey R Dahlen, Kazuo Kitagawa
PURPOSE: To assess the antiplatelet effect of cilostazol clinically, we compared the effects of cilostazol in combination with clopidogrel on various platelet function tests. METHODS: We recruited patients with ischemic stroke at high risk of recurrence who were treated with clopidogrel alone within 180 days after stroke onset. Subjects underwent baseline platelet function tests, and were then randomly assigned to receive dual antiplatelet therapy (DAPT) comprising clopidogrel and cilostazol or clopidogrel monotherapy (SAPT)...
September 23, 2023: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/37708596/plasma-protein-signatures-for-high-on-treatment-platelet-reactivity-to-aspirin-and-clopidogrel-in-peripheral-artery-disease
#19
JOURNAL ARTICLE
G Baidildinova, A Pallares Robles, V Ten Cate, B M M Kremers, S Heitmeier, H Ten Cate, B M E Mees, H M H Spronk, P S Wild, A J Ten Cate-Hoek, K Jurk
BACKGROUND: A significant proportion of patients with peripheral artery disease (PAD) displays a poor response to aspirin and/or the platelet P2Y12 receptor antagonist clopidogrel. This phenomenon is reflected by high on-treatment platelet reactivity (HTPR) in platelet function assays in vitro and is associated with an increased risk of adverse cardiovascular events. OBJECTIVE: This study aimed to elucidate specific plasma protein signatures associated with HTPR to aspirin and clopidogrel in PAD patients...
September 2, 2023: Thrombosis Research
https://read.qxmd.com/read/37679760/implication-of-diabetic-status-on-platelet-reactivity-and-clinical-outcomes-after-drug-eluting-stent-implantation-results-from-the-ptrg-des-consortium
#20
JOURNAL ARTICLE
Ki-Hyun Jeon, Young-Hoon Jeong, In-Ho Chae, Byeong-Keuk Kim, Hyung Joon Joo, Kiyuk Chang, Yongwhi Park, Young Bin Song, Sung Gyun Ahn, Sang Yeub Lee, Jung Rae Cho, Ae-Young Her, Hyo-Soo Kim, Moo Hyun Kim, Do-Sun Lim, Eun-Seok Shin, Jung-Won Suh
BACKGROUND: Diabetes mellitus (DM) is associated with thrombogenicity, clinically manifested with atherothrombotic events after percutaneous cutaneous intervention (PCI). This study aimed to investigate association between DM status and platelet reactivity, and their prognostic implication in PCI-treated patients. METHODS: The Platelet function and genoType-Related long-term Prognosis-Platelet Function Test (PTRG-PFT) cohort was established to determine the linkage of platelet function test (PFT) with long-term prognosis during dual antiplatelet therapy including clopidogrel in patients treated with drug-eluting stent (DES)...
September 7, 2023: Cardiovascular Diabetology
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