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https://www.readbyqxmd.com/read/28806185/graft-quality-verification-in-coronary-artery-bypass-graft-surgery-how-when-and-why
#1
Teresa M Kieser
PURPOSE OF REVIEW: The coronary artery bypass graft (CABG) operation is one of the few remaining operations/interventions on diseased arteries that are not routinely verified during or immediately after the procedure. This review answers the 'how', 'when' and 'why' of intraoperative CABG assessment. RECENT FINDINGS: More recent than new literature on this topic, is the increased interest in quality assurance of CABG. This is most likely due to reports in the last 5 years suggesting CABG superiority to percutaneous coronary intervention (PCI) for improved mid-term and long-term outcomes; for example, for patients with diabetes mellitus (Freedom Trial by Farkouh in 2012), and for patients with SYNTAX score ≥ 33 (SYNTAX Trial by Mohr in 2013)...
August 12, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28772878/fabrication-processes-to-generate-concentration-gradients-in-polymer-solar-cell-active-layers
#2
REVIEW
Shusei Inaba, Varun Vohra
Polymer solar cells (PSCs) are considered as one of the most promising low-cost alternatives for renewable energy production with devices now reaching power conversion efficiencies (PCEs) above the milestone value of 10%. These enhanced performances were achieved by developing new electron-donor (ED) and electron-acceptor (EA) materials as well as finding the adequate morphologies in either bulk heterojunction or sequentially deposited active layers. In particular, producing adequate vertical concentration gradients with higher concentrations of ED and EA close to the anode and cathode, respectively, results in an improved charge collection and consequently higher photovoltaic parameters such as the fill factor...
May 9, 2017: Materials
https://www.readbyqxmd.com/read/28772370/simulation-aided-design-of-tubular-polymeric-capsules-for-self-healing-concrete
#3
Branko Šavija, João Feiteira, Maria Araújo, Sutima Chatrabhuti, Jean-Marie Raquez, Kim Van Tittelboom, Elke Gruyaert, Nele De Belie, Erik Schlangen
Polymeric capsules can have an advantage over glass capsules used up to now as proof-of-concept carriers in self-healing concrete. They allow easier processing and afford the possibility to fine tune their mechanical properties. Out of the multiple requirements for capsules used in this context, the capability of rupturing when crossed by a crack in concrete of a typical size is one of the most relevant, as without it no healing agent is released into the crack. This study assessed the fitness of five types of polymeric capsules to fulfill this requirement by using a numerical model to screen the best performing ones and verifying their fitness with experimental methods...
December 24, 2016: Materials
https://www.readbyqxmd.com/read/28769780/automated-functional-analysis-of-astrocytes-from-chronic-time-lapse-calcium-imaging-data
#4
Yinxue Wang, Guilai Shi, David J Miller, Yizhi Wang, Congchao Wang, Gerard Broussard, Yue Wang, Lin Tian, Guoqiang Yu
Recent discoveries that astrocytes exert proactive regulatory effects on neural information processing and that they are deeply involved in normal brain development and disease pathology have stimulated broad interest in understanding astrocyte functional roles in brain circuit. Measuring astrocyte functional status is now technically feasible, due to recent advances in modern microscopy and ultrasensitive cell-type specific genetically encoded Ca(2+) indicators for chronic imaging. However, there is a big gap between the capability of generating large dataset via calcium imaging and the availability of sophisticated analytical tools for decoding the astrocyte function...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28753559/mir-19b-promotes-breast-cancer-metastasis-through-targeting-mylip-and-its-related-cell-adhesion-molecules
#5
Luqing Zhao, Yuelong Zhao, Yanong He, Yitao Mao
miR-19b is a key molecule for cancer development, however its crucial roles in breast cancer metastasis are rarely studied right now. In this study, using several bioinformatics databases to predict the downstream targets for miR-19b, we verified that a novel target gene, myosin regulatory light chain interacting protein (MYLIP), could be directly down-regulated by miR-19b through its 3'-UTR region. MYLIP belongs to the cytoskeletal protein clusters and is involved in the regulation of cell movement and migration...
July 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28749320/reliability-of-heart-rate-mobile-apps-in-young-healthy-adults-exploratory-study-and-research-directions
#6
Maria Parpinel, Laura Scherling, Stefano Lazzer, Vincenzo Della Mea
BACKGROUND: Recently, a number of smartphone apps appeared that allow for heart rate measurements basing on the photoplethysmography principle. In fact, almost every smartphone now has a camera with flash that could be used for that. Some studies appeared on the reliability of some of those apps, with heterogeneous results. OBJECTIVES: The present study aims at adding up evidence in particular during physical activity, by comparing 3 apps on two different platforms (IOs and Android), on a broad range of heart rates...
June 30, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28741602/journal-of-radiological-protection-now-offers-reviewer-recognition-with-publons
#7
Maggie Simmons
Reviewers for Journal of Radiological Protection (JRP) are now able to track, verify and showcase their peer review contributions. IOP Publishing has partnered with Publons, a free service that enables reviewers to seamlessly have their reviewer records updated in Publons with the click of a button. As of 2017, reviewers for JRP will get the option to have a verified record of each review they do added to their Publons profile. Recognition will be given even if the reviews are anonymous and the manuscript is never published...
July 25, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28701824/liquid-based-and-conventional-cytology-for-bronchial-washings-bronchoalveolar-lavages-in-the-diagnosis-of-malignancy-an-institutional-experience
#8
Abha Thakur, Pooja Bakshi, Gagandeep Kaur, Kusum Verma
BACKGROUND: Liquid-based cytology (LBC) has been developed as an alternative for conventional cytology (CC) in cervical smears. It is now increasingly being used all over the world for cervical cancer screening. However, its role and diagnostic accuracy in bronchial wash (BW)/bronchoalveolar lavage (BAL) specimens remains undetermined. AIMS: To assess and compare the diagnostic performance and accuracy of LBC with CC for detecting malignancy in bronchial specimens...
July 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28700824/application-of-hydrogen-deuterium-exchange-mass-spectrometry-to-biopharmaceutical-development-requirements-improved-sensitivity-to-detection-of-conformational-changes
#9
Lea Bonnington, Ingo Lindner, Ulrich Gilles, Tobias Kailich, Dietmar Reusch, Patrick Bulau
The usefulness of the higher-order structure information provided by hydrogen/deuterium exchange mass spectrometry (HDX-MS) in the protein therapeutic field is undisputed; however, its applicability as a method for critical quality and comparability assessment has until now not been demonstrated. Here we present results demonstrating for the first time the applicability of the HDX-MS technique to monitor structural changes due to methionine oxidation at sensitivity levels realistic to the requirements of biopharmaceutical research and development...
July 28, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28696238/the-sterilizing-effect-of-ertapenem-clavulanate-in-a-hollow-fiber-model-of-tuberculosis-and-implications-on-clinical-dosing
#10
Sander P van Rijn, Shashikant Srivastava, Mireille A Wessels, Dick van Soolingen, Jan-Willem C Alffenaar, Tawanda Gumbo
Carbapenems are now being explored for treatment of multi-drug resistant tuberculosis (MDR-TB), especially in conjunction with clavulanate. Clinical use is constrained by the need for multiple parenteral doses per day, and lack of knowledge of the optimal dose for sterilizing effect. Our objective was to identify the ertapenem exposure associated with optimal sterilizing effect and then design a once a day dose for clinical use. We utilized the hollow fiber system model of tuberculosis in a 28-day exposure-response study of 8 different ertapenem doses in combination with clavulanate...
July 10, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28689303/direct-calorimetry-a-brief-historical-review-of-its-use-in-the-study-of-human-metabolism-and-thermoregulation
#11
REVIEW
Glen P Kenny, Sean R Notley, Daniel Gagnon
Direct calorimetry is the gold standard means of measuring human metabolic rate and its use has been fundamental for understanding metabolism in health and disease. While metabolic rate is now more commonly estimated indirectly from measures of the oxygen consumed during respiration, direct calorimetry provides the user with the unique capacity to quantify the heat produced from aerobic and anaerobic metabolism by measuring heat exchange between the body and the environment. This review provides a brief historical overview of the fundamental concepts which underlie direct calorimetry, of pioneer scientists which developed these concepts into functional pieces of equipment and the subsequent use of direct calorimetry to advance our understanding of energy balance, nutrition, and the pathogenesis of metabolic diseases...
July 8, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28686017/analysis-and-characterization-of-polychlorinated-hydroxybornanes-as-metabolites-of-toxaphene-using-a-polar-bear-model
#12
Lea Reger, Christoph Gallistl, Karl Skírnisson, Walter Vetter
Abiotic and biotic transformation of toxaphene (camphechlor) results in the selective enrichment of recalcitrant congeners while other, less persistent compounds of technical toxaphene (CTTs) are degraded. Until now, there has been little knowledge on oxidation transformation of toxaphene. For instance, the existence of hydroxylated CTTs (OH-CTTs) in authentic environmental and food samples has not been proven. For this reason, we synthesized a mixture consisting of tetra- to heptachlorinated OH-CTTs and simplified it by countercurrent chromatography (CCC)...
July 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28683981/noradrenergic-modulation-of-neural-erotic-stimulus-perception
#13
Heiko Graf, Maike Wiegers, Coraline Danielle Metzger, Martin Walter, Georg Grön, Birgit Abler
We recently investigated neuromodulatory effects of the noradrenergic agent reboxetine and the dopamine receptor affine amisulpride in healthy subjects on dynamic erotic stimulus processing. Whereas amisulpride left sexual functions and neural activations unimpaired, we observed detrimental activations under reboxetine within the caudate nucleus corresponding to motivational components of sexual behavior. However, broadly impaired subjective sexual functioning under reboxetine suggested effects on further neural components...
July 3, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28670191/verifying-sarcoidosis-activity-chitotriosidase-versus-ace-in-sarcoidosis-a-case-control-study
#14
Spasoje Popević, Zorica Šumarac, Dragana Jovanović, Dragan Babić, Mihailo Stjepanović, Snežana Jovičić, Dragana Šobić-Šaranović, Snežana Filipović, Branko Gvozdenović, Maja Omčikus, Anđela Milovanović, Jelica Videnović-Ivanov, Ana Radović, Vladimir Žugić, Violeta Mihailović-Vučinić
BACKGROUND: Until now, a proper biomarker(s) to evaluate sarcoidosis activity has not been recognized. The aims of this study were to evaluate the sensitivity and specificity of the two biomarkers of sarcoidosis activity already in use (serum angiotensin converting enzyme - ACE and serum chitotriosidase) in a population of 430 sarcoidosis patients. The activities of these markers were also analyzed in a group of 264 healthy controls. METHODS: Four hundred and thirty biopsy positive sarcoidosis patients were divided into groups with active and inactive disease, and groups with acute or chronic disease...
October 2016: Journal of Medical Biochemistry
https://www.readbyqxmd.com/read/28666814/national-incidence-of-traumatic-fractures-in-china-a-retrospective-survey-of-512%C3%A2-187-individuals
#15
Wei Chen, Hongzhi Lv, Song Liu, Bo Liu, Yanbin Zhu, Xiao Chen, Guang Yang, Lei Liu, Tao Zhang, Haili Wang, Bing Yin, Jialiang Guo, Xiaolin Zhang, Yichong Li, Derek Smith, Pan Hu, Jiayuan Sun, Yingze Zhang
BACKGROUND: Traumatic fractures place a substantial burden on health-care systems worldwide. Although detailed information about incidence, distribution, and risk factors for traumatic fractures is vital for planning and prevention, in China, national data are unavailable. We aimed to do an up-to-date national survey on the population-weighted incidence of traumatic fractures in China. METHODS: The China National Fracture Study (CNFS) was a retrospective epidemiological study that recruited a nationally representative sample from eight provinces, 24 urban cities, and 24 rural counties in China using stratified random sampling and the probability proportional to size method...
June 27, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28662698/mov10-suppresses-retroelements-and-regulates-neuronal-development-and-function-in-the-developing-brain
#16
Geena Skariah, Joseph Seimetz, Miles Norsworthy, Monica C Lannom, Phillip J Kenny, Mohamed Elrakhawy, Craig Forsthoefel, Jenny Drnevich, Auinash Kalsotra, Stephanie Ceman
BACKGROUND: Moloney leukemia virus 10 (Mov10) is an RNA helicase that mediates access of the RNA-induced silencing complex to messenger RNAs (mRNAs). Until now, its role as an RNA helicase and as a regulator of retrotransposons has been characterized exclusively in cell lines. We investigated the role of Mov10 in the mouse brain by examining its expression over development and attempting to create a Mov10 knockout mouse. Loss of both Mov10 copies led to early embryonic lethality. RESULTS: Mov10 was significantly elevated in postnatal murine brain, where it bound retroelement RNAs and mRNAs...
June 29, 2017: BMC Biology
https://www.readbyqxmd.com/read/28655904/danhong-injection-reduces-vascular-remodeling-and-up-regulates-the-kallikrein-kinin-system-in-spontaneously-hypertensive-rats
#17
Xiaohu Yang, John Orgah, Dandan Wang, Guanwei Fan, Hu Jingyang, Jihong Han, Gangjian Qin, Xiumei Gao, Yan Zhu
Although Danhong injection (DHI) is one of the most prescribed cardiovascular medicines in China, its therapeutic indications and mechanisms remain partially defined. We now identify molecular targets of DHI in resistance vasculatures and demonstrate its role in vascular function and blood pressure (BP) regulation. BP was determined in DHI, Losartan, and placebo- treated Spontaneously Hypertensive Rats (SHR) by both noninvasive and invasive measurements. Vasorelaxation was examined both in conduit and resistance vasculature by ex vivo aortic rings...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28653422/transcutaneous-recharge-a-comparison-of-numerical-simulation-to-in-vivo-experiments
#18
Brian Plourde, Lauren Vallez, Brittany Nelson-Cheeseman, John Abraham
OBJECTIVE: Numerical simulation and animal experiments quantified tissue temperatures during the transcutaneous recharge of neuromodulation implants. The temperature results were used to determine the likelihood of tissue injury in humans. MATERIALS AND METHODS: Experiments were completed using sheep with implants at different depths ranging from 0.7 to 2.15 cm. The calculations were replicates of the experiments. Additional calculations were completed for laterally offset implants (up to 2 cm)...
June 27, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28648656/endovascular-reconstruction-for-chronic-infrarenal-aortoiliac-occlusive-disease
#19
Russell J Pepe, Priya Patel, Lauren A Huntress, Naiem Nassiri
According to the 2007 TransAtlantic Inter-Society Consensus (TASC II) guidelines, surgery is the preferred treatment for extensive (TASC II type C and D) aortoiliac occlusive disease (AIOD). Recent studies, however, have shown that endovascular management can be an effective first-line treatment option for TASC II type C and D categories. While endovascular therapy is now commonly performed in patients with TASC II type D lesions, very few studies have investigated the feasibility and effectiveness of extending endovascular therapy to the most severe subcategory of TASC II D lesions, chronic infrarenal aortoiliac occlusion (CIAO)...
June 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28643301/-application-of-robotic-surgical-system-in-sphincter-preserving-surgery-for-low-rectal-cancer
#20
Pingping Xu, Jianmin Xu
Robotic surgical system has been widely applied in sphincter-preserving surgery for low rectal cancer with the advantages of clear 3D images and stably flexile manipulation. Its application principle includes radical resection of tumor and complete preservation of function. The main operation procedures of robotic surgical system in sphincter-preserving surgery for low rectal cancer are as follows: (1) Anterior resection of low rectal cancer: It is safe and feasible and has obvious advantages in observation of pelvic nerves, dissociation of presacral and sacral side, and high rate of sphincter-preserving, while the improvement of postoperative recovery and long-term survival needs to be verified by further large sample researches...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
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