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https://www.readbyqxmd.com/read/29344131/a-novel-variant-translocation-1-9-p22-q34-resulting-in-a-dek-nup214-fusion-gene-in-a-patient-with-acute-myeloid-leukemia-a-case-report
#1
Qishan Hao, Qi Zhang, Chengwen Li, Shuning Wei, Qinghua Li, Yang Song, Yingchang Mi
The present case report describes a 46-year-old female patient diagnosed with M4 acute myeloid leukemia (AML), accompanied with a t(1;9)(p22;q34) chromosomal abnormality. Transcriptome sequencing identified a DEK proto-oncogene (DEK)/nucleoporin (NUP)214 fusion gene, which results from the t(6;9)(p23;q34) chromosomal translocation. Polymerase chain reaction analysis and fluorescence in situ hybridization were used to verify the existence of the DEK/NUP214 fusion gene. Few patients with AML with the t(6;9)(p23;q34) chromosomal translocation have been reported to have other chromosomal or karyotype changes...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29341939/the-quest-for-equivalence-of-test-results-the-pilgrimage-of-the-dutch-calibration-2-000-program-for-metrological-traceability
#2
REVIEW
Rob T P Jansen, Christa M Cobbaert, Cas Weykamp, Marc Thelen
Calibration 2.000 was initiated 20 years ago for standardization and harmonization of medical tests. The program also intended to evaluate adequate implementation of the In Vitro Diagnostics (IVD) 98/79/EC directive, in order to ensure that medical tests are fit-for-clinical purpose. The Calibration 2.000 initiative led to ongoing verification of test standardization and harmonization in the Netherlands using commutable external quality assessment (EQA)-tools and a type 1 EQA-design, where feasible. National support was guaranteed by involving all laboratory professionals as well as laboratory technicians responsible for EQA and quality officers...
January 17, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29339456/parp-inhibition-prevents-ethanol-induced-neuroinflammatory-signaling-and-neurodegeneration-in-adult-age-rat-brain-slice-cultures
#3
Nuzhath F Tajuddin, Hee-Yong Kim, Michael A Collins
Utilizing rat adult-age hippocampal-entorhinal cortical (HEC) slice cultures we examined the role of poly [ADP-ribose] polymerase (PARP) in binge ethanol's brain inflammatory and neurodegenerative mechanisms. Activated by DNA strand breaks, PARP (principally PARP1 in brain) promotes DNA repair via poly [ADP-ribose] (PAR) products, but PARP overactivation triggers regulated neuronal necrosis, e.g., parthanatos. Previously we found that brain PARP1 levels were upregulated by neurotoxic ethanol binges in adult rats and HEC slices, and PARP inhibitor PJ34 abrogated slice neurodegeneration...
January 16, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29336914/switching-from-clopidogrel-to-prasugrel-to-protect-early-invasive-treatment-in-acute-coronary-syndromes-results-of-the-switch-over-trial
#4
Filippo Ottani, Eti Alessandra Femia, Marco Cattaneo, Luciano Caravita, Chiara Attanasio, Marcello Galvani
BACKGROUND: Clopidogrel is used to pretreat patients with non-ST elevation acute coronary syndromes (NSTE-ACS), but prasugrel provides better platelet inhibition with improved outcome. However, switching from clopidogrel at the time of percutaneous coronary intervention (PCI) remains incompletely defined. Our aim was to compare the pharmacodynamic (PD) effects of 3 prasugrel loading doses (LDs; G1:10mg, G2: 30mg, and G3: 60mg) before PCI. A fourth group, continuing clopidogrel, served as control (G4)...
December 27, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29330294/establishment-of-the-first-well-differentiated-human-pancreatic-neuroendocrine-tumor-model
#5
Daniel Benten, Yasmin Behrang, Ludmilla Unrau, Victoria Weissmann, Gerrit Wolters-Eisfeld, Susanne Burdak-Rothkamm, Felix R Stahl, Martin Anlauf, Patricia Grabowski, Markus Möbs, Jan Dieckhoff, Bence Sipos, Martina Fahl, Corinna Eggers, Daniel Perez, Maximilian Bockhorn, Jakob R Izbicki, Ansgar W Lohse, Joerg Schrader
Clinical options for systemic therapy of neuroendocrine tumors (NET) are limited. Development of new drugs requires suitable representative in vitro and in vivo model systems. So far, the unavailability of a human model with a well-differentiated phenotype and typical growth characteristics has impaired pre-clinical research in NET. Herein, we establish and characterize a lymph node-derived cell line (NT-3) from a male patient with well-differentiated pancreatic NET. Neuroendocrine differentiation and tumor biology was compared to existing NET cell lines BON and QGP-1...
January 12, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29326835/ablation-of-atrial-fibrillation-drivers
#6
Tina Baykaner, Junaid A B Zaman, Paul J Wang, Sanjiv M Narayan
Pulmonary vein isolation (PVI) is central to ablation approaches for atrial fibrillation (AF), yet many patients still have arrhythmia recurrence after one or more procedures, despite evolving technologies for PVI. Ablation of localised AF drivers, which lie outside the pulmonary veins in many patients, is a practical approach that has been shown to improve success by many groups. Such localised drivers lie in atrial regions shown mechanistically to sustain AF in optical mapping and clinical studies of human AF, as well as computational and animal studies...
December 2017: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/29325723/double-function-hydroperoxide-lyases-epoxyalcohol-synthases-cyp74c-of-higher-plants-identification-and-conversion-into-allene-oxide-synthases-by-site-directed-mutagenesis
#7
Yana Y Toporkova, Svetlana S Gorina, Elena K Bessolitsyna, Elena O Smirnova, Valeria S Fatykhova, Fredi Brühlmann, Tatiana M Ilyina, Lucia S Mukhtarova, Alexander N Grechkin
The CYP74C subfamily of fatty acid hydroperoxide transforming enzymes includes hydroperoxide lyases (HPLs) and allene oxide synthases (AOSs). This work reports a new facet of the putative CYP74C HPLs. Initially, we found that the recombinant CYP74C13_MT (Medicago truncatula) behaved predominantly as the epoxyalcohol synthase (EAS) towards the 9(SS)-hydroperoxide of linoleic acid. At the same time, the CYP74C13_MT mostly possessed the HPL activity towards the 13(S)-hydroperoxides of linoleic and α-linolenic acids...
January 8, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29301392/clinical-safety-and-efficacy-of-autologous-bone-marrow-derived-mesenchymal-stem-cell-transplantation-in-sensorineural-hearing-loss-patients
#8
Ho Seok Lee, Woo Jin Kim, Ji Sun Gong, Kyoung Ho Park
Stem cell transplantation represents a promising therapy for several degenerating and necrotic diseases. In several animal studies, we could find hearing restoration after inoculation of the mesenchymal stem cells' as well as mesenchymal stem cells' differentiation of hair cells and spiral ganglion. But until now, no clinical study has been reported directly for the human being. In this pilot studies, we applied mesenchymal stem cells to human beings trans-venously. Although we verified the safety of the autologous bone marrow stem cell transplantation in sensorineural hearing loss patients but we could not achieve significant improvement in hearing...
January 5, 2018: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29300702/the-cost-effectiveness-of-the-online-mindspot-clinic-for-the-treatment-of-depression-and-anxiety-in-australia
#9
Yu-Chen Lee, Lan Gao, Blake F Dear, Nickolai Titov, Cathrine Mihalopoulos
BACKGROUND: The MindSpot Clinic (MindSpot) offers internet-delivered cognitive behavior therapy (iCBT) courses for people with anxiety and depressive disorders in Australia. The efficacy credentials of the courses offered at MindSpot are now well established but not the credentials of cost-effectiveness. The current study is aimed to evaluate the cost-effectiveness of the Wellbeing Course offered in MindSpot in comparison with the routine/usual care (defined as care in the absence of MindSpot) for people with symptoms of depression or/and anxiety from the perspective of Australian Department of Health...
December 1, 2017: Journal of Mental Health Policy and Economics
https://www.readbyqxmd.com/read/29287759/comparative-proteomics-analysis-of-trichinella-spiralis-muscle-larvae-exposure-to-albendazole-sulfoxide-stress
#10
Ruo Yu Peng, Hui Jun Ren, Chun Li Zhang, Pin Lv, Gao Hui Wei, Zhong Quan Wang, Jing Cui, Liang Ming
The drug albendazole (ABZ) has a positive effect against Trichinella spiralis infection and has been used for the treatment and prevention of trichinellosis in both humans and animals. However, the molecular mechanism of ABZ's effects on T. spiralis remains unknown now. Albendazole sulfoxide (ABZSO) is the main intermediary metabolic product of ABZ, and often used as a substitute of ABZ for the metabolism and bioavailability researches. Herein, isobaric tagging reagents for relative and absolute quantification (iTRAQ)-based LC-MS/MS analysis was used to identify the effect of ABZSO on the proteome of T...
December 26, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29281273/time-gated-luminescence-detection-of-enzymatically-produced-hydrogen-sulfide-design-synthesis-and-application-of-a-lanthanide-based-probe
#11
Yao Yao, Loruhama Delgado-Rivera, Hamid Samareh Afsari, Liang Yin, Gregory R J Thatcher, Terry W Moore, Lawrence W Miller
Hydrogen sulfide (H2S) is now recognized as an important gaseous transmitter that is involved in a variety of biological processes. Here, we report the design and synthesis of a luminescent lanthanide biosensor for H2S, LP2-Cu(II)-Ln(III), a heterobinuclear metal complex that uses Cu(II) decomplexation to control millisecond-scale-lifetime-Tb(III)- or Eu(III)-emission intensity. LP2-Cu(II)-Ln(III) responded rapidly, selectively, and with high sensitivity to aqueous H2S. The probe's potential for biological applications was verified by measuring the H2S generated by the slow-releasing chemical-sulfide-donor GYY4147, by cystathionine γ-lyase (CSE), and by Na2S-stimulated HeLa cells...
December 27, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29244823/cost-effectiveness-of-national-health-insurance-programs-in-high-income-countries-a-systematic-review
#12
Son Nghiem, Nicholas Graves, Adrian Barnett, Catherine Haden
OBJECTIVES: National health insurance is now common in most developed countries. This study reviews the evidence and synthesizes the cost-effectiveness information for national health insurance or disability insurance programs across high-income countries. DATA SOURCES: A literature search using health, economics and systematic review electronic databases (PubMed, Embase, Medline, Econlit, RepEc, Cochrane library and Campbell library), was conducted from April to October 2015...
2017: PloS One
https://www.readbyqxmd.com/read/29244727/an-efficient-estimator-for-moving-target-localization-using-multi-station-dual-frequency-radars
#13
Jiyan Huang, Ying Zhang, Shan Luo
Localization of a moving target in a dual-frequency radars system has now gained considerable attention. The noncoherent localization approach based on a least squares (LS) estimator has been addressed in the literature. Compared with the LS method, a novel localization method based on a two-step weighted least squares estimator is proposed to increase positioning accuracy for a multi-station dual-frequency radars system in this paper. The effects of signal noise ratio and the number of samples on the performance of range estimation are also analyzed in the paper...
December 15, 2017: Sensors
https://www.readbyqxmd.com/read/29239957/american-college-of-surgeons-children-s-surgery-verification-quality-improvement-program-what-anesthesiologists-need-to-know-now
#14
Melissa Brooks Peterson, Constance S Houck, Jayant K Deshpande, Randall P Flick
A task force of pediatric surgical specialists with the support of The American College of Surgeons recently launched a verification program for pediatric surgery, the Children's Surgery Verification quality improvement program, with the goal of improving pediatric surgical, procedural, and perioperative care. Included in this program are specific standards for the delivery of pediatric anesthesia care across a variety of practice settings. We review the background, available evidence, requirements for verification, and verification process and its implications for the practice of pediatric anesthesia across the country...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29237426/long-non-coding-rna-malat1-protects-preterm-infants-with-bronchopulmonary-dysplasia-by-inhibiting-cell-apoptosis
#15
Cheng Cai, Jiajun Qiu, Gang Qiu, Yihuan Chen, Zhijun Song, Juan Li, Xiaohui Gong
BACKGROUND: Bronchopulmonary dysplasia (BPD) is a neonatal chronic lung disease characterized by impaired pulmonary alveolar development in preterm infants. Until now, little is known about the molecular and cellular basis of BPD. There is increasing evidence that lncRNAs regulate cell proliferation and apoptosis during lung organogenesis. The potential role of lncRNAs in the pathogenesis of BPD is unclear. This study aims to clarify the role of MALAT1 during the process of BPD in preterm infants and illustrate the protective effect of MALAT1 involved in preterm infants...
December 13, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29235691/rna-interference-mediated-functional-characterization-of-aquaporin-genes-in-tribolium-castaneum
#16
X-X Yao, Q-W Meng, G-Q Li
An obvious challenge faced by most terrestrial insects is maintaining water homeostasis in an arid environment. Current research suggests aquaporins may be evolved to meet the challenge. However, up to now, this suggestion has not been verified in any insect that feeds upon solid food with mandibulate mouthparts. In the present paper, nine putative aquaporin genes [Tribolium castaneum big brain, T. castaneum Drosophila integral protein (TcDrip), T. castaneum Pyrocoelia rufa integral protein (TcPrip), T. castaneum aquaporin 12-like, T...
December 13, 2017: Insect Molecular Biology
https://www.readbyqxmd.com/read/29231789/a-redescription-of-serrasentis-sagittifer-rhadinorhynchidae-serrasentinae-from-rachycentron-canadum-rachycentridae-with-comments-on-its-biology-and-its-relationship-to-other-species-of-serrasentis
#17
Di Barton, Lesley Smales, Jessica Morgan
Adult and cystacanth forms of the acanthocephalan Serrasentis sagittifer from Australian coastal waters are redescribed and verified as the same species using both molecular and morphological data. This study provides the baseline 18S rDNA, 28S rDNA and cox1 sequence data to now genetically barcode S. sagittifer. The validity of the currently recognised species of Serrasentis is discussed, with most previously described species determined as junior synonyms of either Serrasentis nadakali or S. sagittifer; a number of species are also determined as species inquirenda...
December 12, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/29229487/proteomics-reveals-key-proteins-participating-in-growth-difference-between-fall-dormant-and-non-dormant-alfalfa-in-terminal-buds
#18
Hongqi Du, Yinghua Shi, Defeng Li, Wenna Fan, Yanhua Wang, Guoqiang Wang, Chengzhang Wang
To explore the molecular mechanism of growth differences between fall dormant (FD) and non-FD alfalfa, we conducted iTRAQ-based quantitative proteomics on terminal buds of Maverick (FD) and Cuf101 (non-FD) cultivars, identified differential abundance protein species (DAPS) and verified expression profiling of the corresponding mRNA by qRT-PCR. A total of 3872 protein species were annotated. Of the 90 DAPS, 56 and 34 were respectively up- and down-accumulated in Maverick, compared to Cuf101. They were grouped into 35 functional categories and enriched in seven pathways...
December 8, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29218882/improving-the-explainability-of-random-forest-classifier-user-centered-approach
#19
Dragutin Petkovic, Russ Altman, Mike Wong, Arthur Vigil
Machine Learning (ML) methods are now influencing major decisions about patient care, new medical methods, drug development and their use and importance are rapidly increasing in all areas. However, these ML methods are inherently complex and often difficult to understand and explain resulting in barriers to their adoption and validation. Our work (RFEX) focuses on enhancing Random Forest (RF) classifier explainability by developing easy to interpret explainability summary reports from trained RF classifiers as a way to improve the explainability for (often non-expert) users...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29209179/effect-of-transcranial-direct-current-stimulation-of-the-medial-prefrontal-cortex-on-the-gratitude-of-individuals-with-heterogeneous-ability-in-an-experimental-labor-market
#20
Pengcheng Wang, Guangrong Wang, Xiaofei Niu, Huiliang Shang, Jianbiao Li
Gratitude is an important aspect of human sociality, which benefits mental health and interpersonal relationships. Thus, elucidating the neural mechanism of gratitude, which is only now beginning to be investigated, is important. To this end, this study specifies the medial prefrontal cortex (mPFC) involved in the gratitude of heterogeneous individuals using the transcranial direct current stimulation (tDCS) technique. Previous neural studies have shown the involvement of mPFC in social cognition and value evaluation, which are closely related to gratitude...
2017: Frontiers in Behavioral Neuroscience
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