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Xiaoqi Wang
Ozone was discovered in the mid-nineteenth century and is proven to have many therapeutic effects, including its common application as a disinfectant to kill microorganisms in various conditions. Ozone therapies have been utilized for various purposes ever since it was discovered. Extensive studies over a century have verified its therapeutic effects, consistency, and safety with minimal and preventable side effects in medical care. Emerging evidence revealed that ozone also plays important roles in the management and prevention of various skin disorders including infectious skin diseases, skin related allergic diseases, erythema scaly diseases, wound healing and ulcer recovery...
February 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Kimberly Schmitt, Ramesh Akkina
In the current quest for a complete cure for HIV/AIDS, highly sensitive HIV-1 latency detection methods are critical to verify full viral eradication. Until now, the in vitro quantitative viral outgrowth assays (qVOA) have been the gold standard for assessing latent HIV-1 viral burden. However, these assays have been inadequate in detecting the presence of ultralow levels of latent virus in a number of patients who were initially thought to have been cured, but eventually showed viral rebound. In this context, new approaches utilizing in vivo mouse-based VOAs are promising...
2018: Frontiers in Immunology
Wahid Bouida, Kaouthar Beltaief, Houda Baccouche, Mouna Sassi, Zohra Dridi, Imen Trabelsi, Kamel Laaouiti, Taher Chakroun, Ilhem Hellara, Riadh Boukef, Nabil Sakly, Mohsen Hassine, Faouzi Added, Rabie Razgallah, Fadhel Najjar, Semir Nouira
AIMS: Ramadan fasting (RF) may affect aspirin resistance. We conducted this study in patients with cardiovascular risk (CVR) factors to assess the effect of RF on aspirin resistance and explore whether type 2 diabetes mellitus (DM) would influence this effect. METHODS: A total of 177 stable patients with ≥2 CVR factors were recruited. All patients observed RF and were taking aspirin. Physical exam and standard biological tests including glycaemia and serum lipids data were performed before Ramadan (Pre-R), at the last week of Ramadan (R) and four weeks after the end of Ramadan (Post-R)...
2018: PloS One
Yomna I Mahmoud, Asmaa A Mahmoud, Faten S Abo-Zeid, Nagui H Fares
BACKGROUND: Dehydroepiandrosterone (DHEA) is a weak androgen and a crucial precursor of sex steroids. Exogenous supplementation of DHEA is now being commonly used to augment ovarian stimulation in women with diminished ovarian reserve. However, the effects of DHEA are controversial. AIMS: This study verifies the effects of pharmacologic doses of DHEA on the ovarian reserve variables, follicular development, reproductive function, and pregnancy outcomes of perimenopausal rats...
March 8, 2018: Life Sciences
Ron B Schifman, Daniel R Luevano
CONTEXT: - Annual monitoring with serum aluminum measurements is recommended for dialysis patients who are susceptible to toxic accumulation from contaminated dialysis fluid or from ingestion of aluminum-containing medications. OBJECTIVE: - To evaluate long-term trends in serum aluminum concentrations and frequency of chronic toxicity. DESIGN: - A retrospective observational study was conducted by analyzing serum aluminum results obtained from the Veterans Affairs corporate data warehouse...
March 6, 2018: Archives of Pathology & Laboratory Medicine
Deep Bera, Shreyas B Raghunathan, Chao Chen, Zhao Chen, Michiel A P Pertijs, Martin D Verweij, Verya Daeichin, Hendrik J Vos, Antonius F W van der Steen, Nico De Jong, Johan Hans G Bosch
Until now, no matrix transducer has been realized for 3D transesophageal echocardiography (TEE) in pediatric patients. In 3D TEE with a matrix transducer, the biggest challenges are to connect a large number of elements to a standard ultrasound system, and to achieve a high volume rate (>200 Hz). To address these issues, we have recently developed a prototype miniaturized matrix transducer for pediatric patients with micro-beamforming and a small central transmitter. In this paper we propose two multiline parallel 3D beamforming techniques (µBF25 and µBF169) using the micro-beamformed datasets from 25 and 169 transmit events to achieve volume rates of 300 Hz and 44 Hz, respectively...
March 6, 2018: Physics in Medicine and Biology
Fumi Matsui, Muneo Inaba, Kazushige Uchida, Akiyoshi Nishio, Toshiro Fukui, Hideaki Yoshimura, Atsushi Satake, Kazuhiko Yoshioka, Shosaku Nomura, Kazuichi Okazaki
BACKGROUND: Dendritic cells (DCs), primary antigen-presenting cells, are now well known as an immunoregulator of many aspects of immune responses including inflammatory bowel diseases (IBDs) such as Crohn's disease and ulcerative colitis. We have reported that PIR-A/Bhigh cDCs (conventional DCs) appeared in dextran sodium sulfate (DSS)-induced colitis and serve as a negative immunoregulator in an animal model of IBD. The immunoregulatory role of PIR-A/B+ cDCs was confirmed in both an in vitro culture system and an in vivo transfer experiment...
March 5, 2018: Journal of Gastroenterology
Gabriele Mascherini, Benedetta Tosi, Chiara Giannelli, Elisabetta Grifoni, Sonia Degl'innocenti, Giorgio Galanti
BACKGROUND: Improvements in prevention and therapeutic strategies over the years have increased the numbers of breast cancer survivors considerably. Sedentary behavior is now acknowledged to be a risk factor for cancer and cancer relapse. Currently, there are different approaches to increasing the effectiveness of long-term physical activity in these patients. The aim of this study was to verify the long-term effectiveness of a home-based program for active lifestyle change in overweight breast cancer survivors...
March 1, 2018: Journal of Sports Medicine and Physical Fitness
Susanne Saal, Gabriele Meyer, Katrin Beutner, Hanna Klingshirn, Ralf Strobl, Eva Grill, Eva Mann, Sascha Köpke, Michel H C Bleijlevens, Gabriele Bartoszek, Anna-Janina Stephan, Julian Hirt, Martin Müller
BACKGROUND: Joint contractures in nursing home residents limit the capacity to perform daily activities and restrict social participation. The purpose of this study was to develop a complex intervention to improve participation in nursing home residents with joint contractures. METHODS: The development followed the UK Medical Research Council framework using a mixed-methods design with re-analysis of existing interview data using a graphic modelling approach, group discussions with nursing home residents, systematic review of intervention studies, structured 2-day workshop with experts in geriatric, nursing, and rehabilitation, and group discussion with professionals in nursing homes...
February 28, 2018: BMC Geriatrics
Sven Falke, Karsten Dierks, Clement Blanchet, Melissa Graewert, Florent Cipriani, Rob Meijers, Dmitri Svergun, Christian Betzel
Small-angle X-ray scattering (SAXS) analysis of biomolecules is increasingly common with a constantly high demand for comprehensive and efficient sample quality control prior to SAXS experiments. As monodisperse sample suspensions are desirable for SAXS experiments, latest dynamic light scattering (DLS) techniques are most suited to obtain non-invasive and rapid information about the particle size distribution of molecules in solution. A multi-receiver four-channel DLS system was designed and adapted at the BioSAXS endstation of the EMBL beamline P12 at PETRA III (DESY, Hamburg, Germany)...
March 1, 2018: Journal of Synchrotron Radiation
Mauricio Sauerbrey, Lindsay J Rakers, Frank O Richards
The Onchocerciasis Elimination Program for the Americas (OEPA) is a regional initiative and international partnership that has made considerable progress toward its goal since it was launched in 1993. Its strategy is based on mass drug administration of ivermectin (Mectizan, donated by MSD, also known as Merck & Co., Inc., Kenilworth, NJ, USA), twice or four times per year, with at least 85% coverage of eligible populations. From 1989 to 2016, 11 741 276 ivermectin treatments have been given in the Americas, eliminating transmission in 11 of 13 foci...
March 1, 2018: International Health
Claudia Cagnoli, Alessandro Brussino, Cecilia Mancini, Marina Ferrone, Laura Orsi, Paola Salmin, Patrizia Pappi, Elisa Giorgio, Elisa Pozzi, Simona Cavalieri, Eleonora Di Gregorio, Marta Ferrero, Alessandro Filla, Giuseppe De Michele, Cinzia Gellera, Caterina Mariotti, Suran Nethisinghe, Paola Giunti, Giovanni Stevanin, Alfredo Brusco
Spinocerebellar ataxias (SCA) type 1, 2, 3, 6, and 7, associated with a (CAG)n repeat expansion in coding sequences, are the most prevalent autosomal dominant ataxias worldwide (approximately 60% of the cases). In addition, the phenotype of SCA2 expansions has been now extended to Parkinson's disease and amyotrophic lateral sclerosis. Their diagnosis is presently based on a PCR to identify small expanded alleles, followed by a second-level test whenever the suspect of false normal homozygous, or a CAT interruption in SCA1 needs to be verified...
February 17, 2018: Journal of Molecular Diagnostics: JMD
Wei Wang, Qing Li, Tao Yang, Dongsheng Li, Feng Ding, Hongzhi Sun, Guang Bai
Aquaporin 5 (AQP5) is a water channel protein that is over-expressed in many tumors. Elevated expression of AQP5 is associated with poor prognosis of colorectal cancer. Yet, whether AQP5 plays a role in epithelial-mesenchymal transition (EMT) of colorectal cancer has not been reported until now. Here we aim to investigate the function of AQP5 in the EMT process of colorectal cancer. We transfected HCT116 and SW480 cells with AQP5-specific shRNA and verified the knockdown efficiency through western blotting and real-time PCR...
February 17, 2018: Cytotechnology
Bregje Aj van Spijker, Aliza Werner-Seidler, Philip J Batterham, Andrew Mackinnon, Alison L Calear, John A Gosling, Julia Reynolds, Ad Jfm Kerkhof, Daniela Solomon, Fiona Shand, Helen Christensen
BACKGROUND: Treatment for suicidality can be delivered online, but evidence for its effectiveness is needed. OBJECTIVE: The goal of our study was to examine the effectiveness of an online self-help intervention for suicidal thinking compared to an attention-matched control program. METHODS: A 2-arm randomized controlled trial was conducted with assessment at postintervention, 6, and, 12 months. Through media and community advertizing, 418 suicidal adults were recruited to an online portal and were delivered the intervention program (Living with Deadly Thoughts) or a control program (Living Well)...
February 14, 2018: Journal of Medical Internet Research
Hao Yu, Zheng Qian, Huayi Liu, Jiaqi Qu
This paper analyzes the measurement error, caused by the position of the current-carrying conductor, of a circular array of magnetic sensors for current measurement. The circular array of magnetic sensors is an effective approach for AC or DC non-contact measurement, as it is low-cost, light-weight, has a large linear range, wide bandwidth, and low noise. Especially, it has been claimed that such structure has excellent reduction ability for errors caused by the position of the current-carrying conductor, crosstalk current interference, shape of the conduction cross-section, and the Earth's magnetic field...
February 14, 2018: Sensors
Bilal Ahmad, Anindyajit Banerjee, Harshita Tiwari, Shrabasti Jana, Sudeshna Bose, Saikat Chakrabarti
Vinblastine and its related compound vincristine are important mono terpenoid indole alkaloids accumulated in the leaves of Catharanthus roseus (Madagascar periwinkle). They serve as major anticancer drugs. Vinblastine is formed by the condensation of vindoline and catharanthine. The vindoline moiety is derived from tabersonine via vindoline biosynthesis pathway. The reaction sequence from tabersonine to vindoline is now well established and the enzymes involved in this pathway are identified. However, to date, the structures of the enzymes involved in the vindoline biosynthesis pathway are not known, leading to limited mechanistic understanding of the substrate binding and catalysis...
February 13, 2018: Journal of Molecular Modeling
Dominik Danso, Christel Schmeisser, Jennifer Chow, Wolfgang Zimmermann, Ren Wei, Christian Leggewie, Xiangzhen Li, Terry Hazen, Wolfgang R Streit
Polyethylene terephthalate (PET) is one of the most important synthetic polymers used nowadays. Unfortunately, the polymers accumulate in nature and until now, no highly active enzymes are known that can degrade it at high velocity. Enzymes involved in PET degradation are mainly α/β-hydrolases like cutinases and related enzymes (E.C. 3.1.-). Currently, only a small number of such enzymes are well characterized. Within this work, a search algorithm was developed that identified 504 possible PET hydrolase candidate genes from various databases...
February 2, 2018: Applied and Environmental Microbiology
Laiquan Huang, Kun He, Jianxin Wang, Jiawei Yan, Yizhi Jiang, Zhongling Wei, Jun Zhang, Guangxi Li, Dongping Huang
Eukaryotic translation initiation factors 3B (eIF3b) is a subtype of the eIF3 category, which has been verified to be over-expressed in colon cancer, bladder, prostate cancers and glioblastoma due to its impact on the cellular activity of cancer cells. However, no related research on exploring the correlation of eIF3b gene expression with cell proliferation and apoptosis in chronic myeloid leukemia (CML) has been conducted until now. Our study showed that the expression of eIF3b mRNA in CML patients was higher compared with nonmalignancy controls...
February 8, 2018: Oncology Research
Cristhina Bonilha Huster Siegle, Cristina Dos Santos Cardoso de Sá
BACKGROUND: Exposure to HIV during pregnancy is a risks to development. Exposed child should have assessed its development since birth. Alberta Infant Motor Scale is a tool which assess gross motor skills, with easy application and low cost. Up to now, this scale had not proven its validity for the population exposed to HIV. It's necessary to compare its with a gold standard tool, Bayley scale, which assess gross and fine motor skills, has a high cost and longer application time required...
February 1, 2018: Infant Behavior & Development
Di Che, Chuanbowen Sun, William Shieh
Direct detection is traditionally regarded as a detection method that recovers only the optical intensity. Compared with coherent detection, it owns a natural advantage-the simplicity-but lacks a crucial capability of field recovery that enables not only the multi-dimensional modulation, but also the digital compensation of the fiber impairments linear with the optical field. Full-field detection is crucial to increase the capacity-distance product of optical transmission systems. A variety of methods have been investigated to directly detect the optical field of the single polarization mode, which normally sends a carrier traveling with the signal for self-coherent detection...
February 5, 2018: Optics Express
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