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https://www.readbyqxmd.com/read/28653422/transcutaneous-recharge-a-comparison-of-numerical-simulation-to-in-vivo-experiments
#1
Brian Plourde, Lauren Vallez, Brittany Nelson-Cheeseman, John Abraham
OBJECTIVE: Numerical simulation and animal experiments quantified tissue temperatures during the transcutaneous recharge of neuromodulation implants. The temperature results were used to determine the likelihood of tissue injury in humans. MATERIALS AND METHODS: Experiments were completed using sheep with implants at different depths ranging from 0.7 to 2.15 cm. The calculations were replicates of the experiments. Additional calculations were completed for laterally offset implants (up to 2 cm)...
June 27, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28648656/endovascular-reconstruction-for-chronic-infrarenal-aortoiliac-occlusive-disease
#2
Russell J Pepe, Priya Patel, Lauren A Huntress, Naiem Nassiri
According to the 2007 TransAtlantic Inter-Society Consensus (TASC II) guidelines, surgery is the preferred treatment for extensive (TASC II type C and D) aortoiliac occlusive disease (AIOD). Recent studies, however, have shown that endovascular management can be an effective first-line treatment option for TASC II type C & D categories. While endovascular therapy is now commonly performed in patients with TASC II type D lesions, very few studies have investigated the feasibility and effectiveness of extending endovascular therapy to the most severe subcategory of TASC II D lesions, chronic infrarenal aortoiliac occlusion (CIAO)...
June 22, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28643301/-application-of-robotic-surgical-system-in-sphincter-preserving-surgery-for-low-rectal-cancer
#3
Pingping Xu, Jianmin Xu
Robotic surgical system has been widely applied in sphincter-preserving surgery for low rectal cancer with the advantages of clear 3D images and stably flexile manipulation. Its application principle includes radical resection of tumor and complete preservation of function. The main operation procedures of robotic surgical system in sphincter-preserving surgery for low rectal cancer are as follows: (1) Anterior resection of low rectal cancer: It is safe and feasible and has obvious advantages in observation of pelvic nerves, dissociation of presacral and sacral side, and high rate of sphincter-preserving, while the improvement of postoperative recovery and long-term survival needs to be verified by further large sample researches...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28631696/-ankylosing-spondylitis-and-non-radiographic-axial-spondyloarthritis-two-stages-of-disease
#4
D G Rumyantseva, T V Dubinina, A B Demina, O A Rumyantseva, E M Agafonova, A V Smirnov, Sh F Erdes
AIM: To compare the clinical manifestations of ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nrAxSpA). SUBJECTS AND METHODS: A Moscow early spondyloarthritis cohort has now included 132 patients with axial spondyloarthritis, of whom 69 patients who have been followed up at least 12 months are to be involved in a preliminary analysis. The mean age at the time of inclusion in the study was 28.1±5.5 years; the mean disease duration was 24...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28629618/conditioning-and-robustness-of-rna-boltzmann-sampling-under-thermodynamic-parameter-perturbations
#5
Emily Rogers, David Murrugarra, Christine Heitsch
Understanding how RNA secondary structure prediction methods depend on the underlying nearest-neighbor thermodynamic model remains a fundamental challenge in the field. Minimum free energy (MFE) predictions are known to be "ill conditioned" in that small changes to the thermodynamic model can result in significantly different optimal structures. Hence, the best practice is now to sample from the Boltzmann distribution, which generates a set of suboptimal structures. Although the structural signal of this Boltzmann sample is known to be robust to stochastic noise, the conditioning and robustness under thermodynamic perturbations have yet to be addressed...
June 16, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28612896/total-thyroidectomy-the-first-the-best-the-recurrent-goiter-issue
#6
A Cappellani, A Zanghì, F Cardì, A Cavallaro, G Piccolo, S Palmucci, G Fuccio Sanzà, M Di Vita
BACKGROUND: Redo surgery for recurrent goiter is still now, even in experienced hands, followed by higher morbidity than primary total thyroidectomy. Suppressive Levothyroxine therapy failed to improve the recurrence rate, while inducing a subclinical hyperthyroidism. Aim of this study is to verify morbidity after total thyroidectomy for benign thyroid diseases, both primary and after recurrence. MATERIALS AND METHODS: A series of 20 cases of total thyroidectomy for recurrent benign diseases (RG), performed between January 2001 and December 2013 was compared with 225 cases of primary total thyroidectomy (PT) ...
May 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28611743/identification-and-characterization-of-mycoplasma-feriruminatoris-sp-nov-strains-isolated-from-alpine-ibex-a-4th-species-in-the-mycoplasma-mycoides-cluster-hosted-by-non-domesticated-ruminants
#7
Chloé Ambroset, Corinne Pau-Roblot, Yvette Game, Patrice Gaurivaud, Florence Tardy
The genus Mycoplasma, a group of free-living, wall-less prokaryotes includes more than 100 species of which dozens are primary pathogens of humans and domesticated animals. Mycoplasma species isolated from wildlife are rarely investigated but could provide a fuller picture of the evolutionary history and diversity of this genus. In 2013 several isolates from wild Caprinae were tentatively assigned to a new species, Mycoplasma (M.) feriruminatoris sp. nov., characterized by an unusually rapid growth in vitro and close genetic proximity to ruminant pathogenic species...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28604657/in-beam-measurement-of-the-hydrogen-hyperfine-splitting-and-prospects-for-antihydrogen-spectroscopy
#8
M Diermaier, C B Jepsen, B Kolbinger, C Malbrunot, O Massiczek, C Sauerzopf, M C Simon, J Zmeskal, E Widmann
Antihydrogen, the lightest atom consisting purely of antimatter, is an ideal laboratory to study the CPT symmetry by comparison with hydrogen. With respect to absolute precision, transitions within the ground-state hyperfine structure (GS-HFS) are most appealing by virtue of their small energy separation. ASACUSA proposed employing a beam of cold antihydrogen atoms in a Rabi-type experiment, to determine the GS-HFS in a field-free region. Here we present a measurement of the zero-field hydrogen GS-HFS using the spectroscopy apparatus of ASACUSA's antihydrogen experiment...
June 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28588426/effects-of-ramadan-fasting-on-platelet-reactivity-in-diabetic-patients-treated-with-clopidogrel
#9
W Bouida, H Baccouche, M Sassi, Z Dridi, T Chakroun, I Hellara, R Boukef, M Hassine, F Added, R Razgallah, I Khochtali, S Nouira
BACKGROUND: The effects of Ramadan fasting (RF) on clopidogrel antiplatelet inhibition were not previously investigated. The present study evaluated the influence of RF on platelet reactivity in patients with high cardiovascular risk (CVR) in particular those with type 2 diabetes mellitus (DM). METHODS: A total of 98 stable patients with ≥2 CVR factors were recruited. All patients observed RF and were taking clopidogrel at a maintenance dose of 75 mg. Clinical findings and serum lipids data were recorded before Ramadan (Pre-R), at the last week of Ramadan (R) and 4 weeks after the end of Ramadan (Post-R)...
2017: Thrombosis Journal
https://www.readbyqxmd.com/read/28587109/identification-of-non-electrophilic-nrf2-activators-from-approved-drugs
#10
Qing-Ye Zhang, Xin-Yi Chu, Ling-Han Jiang, Meng-Yuan Liu, Zhi-Ling Mei, Hong-Yu Zhang
Oxidative damage can lead to a wide range of diseases. Nrf2 is an important transcription factor that regulates many of the cytoprotective enzymes involved in the oxidative stress response. Therefore, targeting the regulation of Nrf2 activation is one logical and effective strategy to prevent or lower the risk of oxidative stress-related diseases. Until now, most research has focused on electrophilic indirect Nrf2 activators, but the risk of 'off-target' effects may be associated with these activators. To find novel small non-electrophilic modulators of Nrf2, we started from chemical agents derived from a connectivity map (cMap) and identified 22 non-electrophilic potential Nrf2-activating drugs through a drug repositioning tactic...
May 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28585481/novel-approaches-to-develop-community-built-biological-network-models-for-potential-drug-discovery
#11
Marja Talikka, Natalia Bukharov, William S Hayes, Martin Hofmann-Apitius, Leonidas Alexopoulos, Manuel C Peitsch, Julia Hoeng
Hundreds of thousands of data points are now routinely generated in clinical trials by molecular profiling and NGS technologies. A true translation of this data into knowledge is not possible without analysis and interpretation in a well-defined biology context. Currently, there are many public and commercial pathway tools and network models that can facilitate such analysis. At the same time, insights and knowledge that can be gained is highly dependent on the underlying biological content of these resources...
June 6, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28583084/expression-and-functional-analysis-of-the-transcription-factor-encoding-gene-cserf004-in-cucumber-during-pseudoperonospora-cubensis-and-corynespora-cassiicola-infection
#12
Dong Liu, Ming Xin, Xiuyan Zhou, Chunhua Wang, Yanju Zhang, Zhiwei Qin
BACKGROUND: Cucumber downy mildew, caused by P. cubensis, is an important leaf disease that can severely affect cucumber production. In recent years, cucumber target spot, caused by C. cassiicola, has been reported in both Asia and Europe and is now considered as a major disease disrupting cucumber production. Single-disease-resistant cucumber varieties have been unable to satisfy production needs. To explore the molecular mechanisms of cucumber resistance to these two diseases, cucumber cultivars D9320 (resistant to downy mildew and target spot) and D0401 (susceptible to downy mildew and target spot) were used as experimental materials in this study...
June 5, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28573557/synthesis-of-the-ddt-metabolite-2-4-dichloro-1-2-chloro-1-4-chlorophenyl-ethenyl-benzene-o-cl-ddmu-and-its-detection-in-abiotic-and-biotic-samples
#13
Christoph Gallistl, Katie Proctor, Korinna Bader, Walter Vetter
Technical dichlorodiphenyltrichloroethane (DDT) has been used worldwide as a pesticide since the beginning of the 1940s. Due to its persistence, DDT residues are still ubiquitously distributed in the environment. Photochemical UV degradation has been shown to be a potent degradation path for DDT and most of the resulting photoproducts have been identified up to now. Nevertheless, in 2012, a new DDT metabolite, most likely formed photochemically from DDE, was detected in ray liver samples from Brazil, an area which is highly contaminated with DDT...
June 1, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28552844/pd-l1-a-novel-prognostic-biomarker-in-head-and-neck-squamous-cell-carcinoma
#14
Tim Müller, Martin Braun, Dimo Dietrich, Seher Aktekin, Simon Höft, Glen Kristiansen, Friederike Göke, Andreas Schröck, Johannes Brägelmann, Stefanie A E Held, Friedrich Bootz, Peter Brossart
BACKGROUND: The PD-1 receptor and its ligands PD-L1 and PD-L2 are known to be significantly involved in T-cell regulation. Recent studies suggest that PD-L1 expression in malignant tumors contributes to an immunosuppressive microenvironment and disruption of antitumoral immune response. Drugs targeting this pathway are already tested in clinical trials against several tumor entities with promising results. However, until now comprehensive data with regard to PD-L1 and PD-L2 expression in head and neck squamous cell carcinoma (HNSCC) is still lacking...
May 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28530504/functional-recovery-after-rotator-cuff-repair-the-role-of-biceps-surgery
#15
Bernardo Gialanella, Francesco Grossetti, Marina Mazza, Laura Danna, Laura Comini
CONTEXT: Surgical cuff repair is indicated in full-thickness rotator cuff tear when non-operative treatment fails. Surgical cuff repair can comprehend surgery of long head of the biceps when concomitant biceps pathology is present. However, the studies executed up to now do not have yet clearly defined if additional biceps surgery affects the shoulder functionality in patients who underwent rotator cuff repair. OBJECTIVE: The aim of this study is to verify if the concomitant biceps surgery prejudices the shoulder functionality during the short-term period in rotator cuff repair patients...
May 22, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28520845/follow-up-of-a-large-prospective-united-states-cohort-by-linkage-with-multiple-state-cancer-registries
#16
Eric J Jacobs, Peter J Briggs, Anusila Deka, Christina C Newton, Kevin C Ward, Betsy A Kohler, Susan M Gapstur, Alpa V Patel
All states in the United States now have a well-established cancer registry. Linkage with these registries may be a cost-effective method of follow-up for cancer incidence in multi-state cohort studies. However, the sensitivity of linkage with the current network of state registries for detecting incident cancer diagnoses within cohort studies is not well-documented. We examined the sensitivity of registry linkage among 39,368 men and women from 23 states who enrolled in the Cancer Prevention Study-3 cohort from 2006-2009 and had the opportunity to self-report cancer diagnoses on a questionnaire in 2011...
May 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28511651/high-resolution-mucociliary-transport-measurement-in-live-excised-large-animal-trachea-using-synchrotron-x-ray-imaging
#17
Martin Donnelley, Kaye S Morgan, Maged Awadalla, Nigel R Farrow, Chris Hall, David W Parsons
BACKGROUND: The Australian Synchrotron Imaging and Medical Beamline (IMBL) was designed as the world's widest synchrotron X-ray beam, enabling both clinical imaging and therapeutic applications for humans as well as the imaging of large animal models. Our group is developing methods for imaging the airways of newly developed CF animal models that display human-like lung disease, such as the CF pig, and we expect that the IMBL can be utilised to image airways in animals of this size. METHODS: This study utilised samples of excised tracheal tissue to assess the feasibility, logistics and protocols required for airway imaging in large animal models such as pigs and sheep at the IMBL...
May 16, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28507680/an-albumin-based-tumor-targeted-oxaliplatin-prodrug-with-distinctly-improved-anticancer-activity-in-vivo
#18
Josef Mayr, Petra Heffeter, Diana Groza, Luis Galvez, Gunda Koellensperger, Alexander Roller, Beatrix Alte, Melanie Haider, Walter Berger, Christian R Kowol, Bernhard K Keppler
The design of targeted platinum(iv) prodrugs is a very promising approach to enhance the low selectivity of platinum(ii) drugs towards cancerous tissue in order to reduce the impact on healthy tissue and, consequently, the often severe side-effects. Herein, we report a set of mono-functionalized cis- and oxaliplatin-based platinum(iv) complexes bearing a maleimide moiety, which allows selective binding to serum albumin in the bloodstream. This leads not only to a prolonged plasma half-life by avoidance of fast renal clearance, but also to preferential accumulation of the drug in the tumor tissue due to the EPR-effect...
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28483832/screening-for-atrial-fibrillation-a-report-of-the-af-screen-international-collaboration
#19
REVIEW
Ben Freedman, John Camm, Hugh Calkins, Jeffrey S Healey, Mårten Rosenqvist, Jiguang Wang, Christine M Albert, Craig S Anderson, Sotiris Antoniou, Emelia J Benjamin, Giuseppe Boriani, Johannes Brachmann, Axel Brandes, Tze-Fan Chao, David Conen, Johan Engdahl, Laurent Fauchier, David A Fitzmaurice, Leif Friberg, Bernard J Gersh, David J Gladstone, Taya V Glotzer, Kylie Gwynne, Graeme J Hankey, Joseph Harbison, Graham S Hillis, Mellanie T Hills, Hooman Kamel, Paulus Kirchhof, Peter R Kowey, Derk Krieger, Vivian W Y Lee, Lars-Åke Levin, Gregory Y H Lip, Trudie Lobban, Nicole Lowres, Georges H Mairesse, Carlos Martinez, Lis Neubeck, Jessica Orchard, Jonathan P Piccini, Katrina Poppe, Tatjana S Potpara, Helmut Puererfellner, Michiel Rienstra, Roopinder K Sandhu, Renate B Schnabel, Chung-Wah Siu, Steven Steinhubl, Jesper H Svendsen, Emma Svennberg, Sakis Themistoclakis, Robert G Tieleman, Mintu P Turakhia, Arnljot Tveit, Steven B Uittenbogaart, Isabelle C Van Gelder, Atul Verma, Rolf Wachter, Bryan P Yan
Approximately 10% of ischemic strokes are associated with atrial fibrillation (AF) first diagnosed at the time of stroke. Detecting asymptomatic AF would provide an opportunity to prevent these strokes by instituting appropriate anticoagulation. The AF-SCREEN international collaboration was formed in September 2015 to promote discussion and research about AF screening as a strategy to reduce stroke and death and to provide advocacy for implementation of country-specific AF screening programs. During 2016, 60 expert members of AF-SCREEN, including physicians, nurses, allied health professionals, health economists, and patient advocates, were invited to prepare sections of a draft document...
May 9, 2017: Circulation
https://www.readbyqxmd.com/read/28470438/a-novel-physical-colonoscopy-simulator-based-on-analysis-of-data-from-computed-tomography-colonography
#20
Katsuhisa Noda, Takatoshi Kitada, Yasumoto Suzuki, Hugh Shunsuke Colvin, Taishi Hata, Tsunekazu Mizushima
PURPOSE: Laparoscopic surgery is now practiced widely because of its lower postoperative morbidity. As flexible endoscopy during laparoscopic surgery minimizes surgical trauma further, training in endoscopy will become more important for surgeons. Thus, we designed a physical simulator, the Noda-Kitada-Suzuki (NKS) model, which could provide the more realistic insertion of a colonoscope. METHODS: We designed a colonoscopy simulator, based on information from computed tomography colonography scans of the anatomy and kinetic properties of the colon and rectum...
May 3, 2017: Surgery Today
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