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https://www.readbyqxmd.com/read/28915832/dogs-as-victims-of-their-own-worms-serodiagnosis-of-canine-alveolar-echinococcosis
#1
C F Frey, N Marreros, S Renneker, L Schmidt, H Sager, B Hentrich, S Milesi, B Gottstein
BACKGROUND: Besides acting as definitive hosts for Echinococcus multilocularis, dogs can become infected by the larval form of this parasite and thereby develop life-threatening alveolar echinococcosis (AE). Although AE is a zoonotic disease, most therapeutic and diagnostic approaches have been developed for human patients. In dogs, AE is typically diagnosed in the advanced stage of the disease when the parasitic mass has already caused abdominal distension. At that stage, complete resection of the parasitic mass is often impossible, leaving a guarded prognosis for the affected dogs...
September 16, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28912145/dynamic-18-f-fdg-pet-lymphography-for-in-vivo-identification-of-lymph-node-metastases-in-murine-melanoma
#2
Hannah H Lockau, Volker Neuschmelting, Anuja Ogirala, Antoni Vilaseca, Jan Grimm
Objective: Positron Lymphography using (18)F-FDG followed by Cerenkov guided resection of lymph nodes in healthy mice has previously been introduced by our group. Our aim in this study was to further assess the technique`s potential beyond merely localizing sentinel lymph nodes. We now aimed to evaluate the potential of Positron Lymphography to characterize the nodes with respect to their tumor status on order to identify metastatic lymph nodes. We explored if metastatic nodes could be distinguished from normal nodes via dynamic (18)F-FDG-lymphography, in order to then be resected under Cerenkov imaging guidance...
September 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28898878/development-of-laboratory-investigations-in-disorders-of-sex-development
#3
Laura Audí, Núria Camats, Mónica Fernández-Cancio, María L Granada
Scientific knowledge to understand the biological basis of sex development was prompted by the observation of variants different from the 2 most frequent body types, and this became one of the fields first studied by modern pediatric endocrinology. The clinical observation was supported by professionals working in different areas of laboratory sciences which led to the description of adrenal and gonadal steroidogenesis, the enzymes involved, and the different deficiencies. Steroid hormone measurements evolved from colorimetry to radioimmunoassay (RIA) and automated immunoassays, although gas and liquid chromatography coupled to mass spectrometry are now the gold standard techniques for steroid measurements...
September 13, 2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/28888935/viscoplastic-crack-initiation-and-propagation-in-crosslinked-uhmwpe-from-clinically-relevant-notches-up-to-0-5mm-radius
#4
P Abhiram Sirimamilla, Clare M Rimnac, Jevan Furmanski
Highly crosslinked UHMWPE is now the material of choice for hard-on-soft bearing couples in total joint replacements. However, the fracture resistance of the polymer remains a design concern for increased longevity of the components in vivo. Fracture research utilizing the traditional linear elastic fracture mechanics (LEFM) or elastic plastic fracture mechanics (EPFM) approach has not yielded a definite failure criterion for UHMWPE. Therefore, an advanced viscous fracture model has been applied to various notched compact tension specimen geometries to estimate the fracture resistance of the polymer...
September 1, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28885215/hyperspectral-imaging-as-a-novel-diagnostic-tool-in-microcirculation-of-wounds
#5
Georg Daeschlein, Inga Langner, Thomas Wild, Sebastian von Podewils, Claudia Sicher, Thomas Kiefer, Michael Jünger
Monitoring of perfusion is a cornerstone in surgery, phlebology and basic science to proof wound healing by interventions. In chronic wound management it is of utmost importance to realize and parametrize wound bed perfusion to verify actual, and plan further treatment by noninvasive diagnostics. Up to now monitoring is based on visual inspection of wounds as conventionally practiced over more than decades. The main problems of visual inspection are the lack of standardization and comparability because of interindividual variations...
September 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28881780/pd-l1-a-novel-prognostic-biomarker-in-head-and-neck-squamous-cell-carcinoma
#6
Tim Müller, Martin Braun, Dimo Dietrich, Seher Aktekin, Simon Höft, Glen Kristiansen, Friederike Göke, Andreas Schröck, Johannes Brägelmann, Stefanie A E Held, Friedrich Bootz, Peter Brossart
BACKGROUND: The PD-1 receptor and its ligands PD-L1 and PD-L2 are known to be significantly involved in T-cell regulation. Recent studies suggest that PD-L1 expression in malignant tumors contributes to an immunosuppressive microenvironment and disruption of antitumoral immune response. Drugs targeting this pathway are already tested in clinical trials against several tumor entities with promising results. However, until now comprehensive data with regard to PD-L1 and PD-L2 expression in head and neck squamous cell carcinoma (HNSCC) is still lacking...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28873418/empirical-research-on-kano-s-model-and-customer-satisfaction
#7
Feng-Han Lin, Sang-Bing Tsai, Yu-Cheng Lee, Cheng-Fu Hsiao, Jie Zhou, Jiangtao Wang, Zhiwen Shang
Products are now developed based on what customers desire, and thus attractive quality creation has become crucial. In studies on customer satisfaction, methods for analyzing quality attributes and enhancing customer satisfaction have been proposed to facilitate product development. Although substantial studies have performed to assess the impact of the attributes on customer satisfaction, little research has been conducted that quantitatively calculate the odds of customer satisfaction for the Kano classification, fitting a nonlinear relationship between attribute-level performance and customer satisfaction...
2017: PloS One
https://www.readbyqxmd.com/read/28869780/deciphering-the-enigma-of-undetected-species-phylogenetic-and-functional-diversity-based-on-good-turing-theory
#8
Anne Chao, Chun-Huo Chiu, Robert K Colwell, Luiz Fernando S Magnago, Robin L Chazdon, Nicholas J Gotelli
Estimating the species, phylogenetic, and functional diversity of a community is challenging because rare species are often undetected, even with intensive sampling. The Good-Turing frequency formula, originally developed for cryptography, estimates in an ecological context the true frequencies of rare species in a single assemblage based on an incomplete sample of individuals. Until now, this formula has never been used to estimate undetected species, phylogenetic, and functional diversity. Here, we first generalize the Good-Turing formula to incomplete sampling of two assemblages...
September 4, 2017: Ecology
https://www.readbyqxmd.com/read/28856789/longitudinal-telomere-shortening-and-early-alzheimer-s-disease-progression-in-adults-with-down-syndrome
#9
Edmund C Jenkins, Elaine J Marchi, Milen T Velinov, Lingling Ye, Sharon J Krinsky-McHale, Warren B Zigman, Nicole Schupf, Wayne P Silverman
Telomere shortening was shown to parallel Alzheimer's disease (AD) associated dementia. By using a dual PNA Probe system we have developed a practical method for comparing telomere length in T-lymphocyte interphases from individuals with Down syndrome (DS) with and without "mild cognitive impairment" (MCI-DS) and demonstrated that telomere length can serve as a valid biomarker for the onset of MCI-DS in this high-risk population. To verify progressive cognitive decline we have now examined sequential changes in telomere length in 10 adults with DS (N = 4 Female, N = 6 Male) developing MCI-DS...
August 30, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28831344/rhinoplasty-setsquare-device-a-novel-instrument-to-verify-columellar-and-nasal-dorsal-position-at-the-midsagittal-line
#10
Aret Çerçi Özkan
Even a mild degree of postoperative deviation of the nasal dorsum and/or columella from the midsagittal plane could be enough to displease a patient. Postoperative judgment of the nasal dorsum and the columellar positioning on the midsagittal plane is somewhat of a subjective decision determined by the surgeons' naked eye. Most innovations tend to evolve from necessities. The risk and reality of misjudging the positioning for both the nasal dorsum and/or the columella led me to develop a device for the objective measurement of the midsagittal axis of the nose...
July 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28813980/human-mimetic-forearm-mechanism-towards-bionic-arm
#11
Minsang Seo, Hogyun Kim, Youngjin Choi
The paper presents a mechanical forearm mechanism to extend the pronation and supination (P/S) movement of the trans-radial amputee when he/she is able to conduct the P/S motion partially with his/her remaining forearm. The P/S motions of the existing prostheses and robotic arms developed till now are completely different from those of the human. When we are to develop the robotic prostheses for the amputees, two important issues should be considered such as cosmetic issue to look like normal arm and motion harmony issue between robotic prosthesis and the amputated living arm...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28809638/-four-corner-arthrodesis-of-the-wrist-with-dorsal-circular-plate-a-retrospective-monocentric-study
#12
T Zatrapa, D Veigl, J Pech, I Landor, M Šimková
PURPOSE OF THE STUDY Our study aimed to evaluate a group of patients who in the period from 2005 to 2014 underwent a four-corner arthrodesis of the wrist in our department. We also wanted to verify the hypothesis as to whether the use of conventional dorsal plate without the application of bone grafts leads to comparable results as the use of dorsal locking plates and routine application of bone grafts. MATERIAL AND METHODS Throughout the years 2005 to 2014 the four-corner arthrodesis of the wrist was performed in our department in a total of 62 patients, in two cases bilaterally...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28807931/identification-of-novel-growth-regulators-in-plant-populations-expressing-random-peptides
#13
Zhilong Bao, Maureen A Clancy, Raquel F Carvalho, Kiona Elliott, Kevin M Folta
The use of chemical genomics approaches allows the identification of small molecules that integrate into biological systems, thereby changing discrete processes that influence growth, development or metabolism. Libraries of chemicals are applied to living systems, and changes in phenotype are observed, potentially leading to the identification of new growth regulators. This work describes an approach that is the nexus of chemical-genomics and synthetic biology. Here each plant in an extensive population synthesizes a unique small peptide arising from a transgene composed of a randomized nucleic acid sequence core, flanked by translational start, stop, and cysteine-encoding (for disulfide cyclization) sequences...
August 14, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28806185/graft-quality-verification-in-coronary-artery-bypass-graft-surgery-how-when-and-why
#14
Teresa M Kieser
PURPOSE OF REVIEW: The coronary artery bypass graft (CABG) operation is one of the few remaining operations/interventions on diseased arteries that are not routinely verified during or immediately after the procedure. This review answers the 'how', 'when' and 'why' of intraoperative CABG assessment. RECENT FINDINGS: More recent than new literature on this topic, is the increased interest in quality assurance of CABG. This is most likely due to reports in the last 5 years suggesting CABG superiority to percutaneous coronary intervention (PCI) for improved mid-term and long-term outcomes; for example, for patients with diabetes mellitus (Freedom Trial by Farkouh in 2012), and for patients with SYNTAX score ≥ 33 (SYNTAX Trial by Mohr in 2013)...
August 12, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28772878/fabrication-processes-to-generate-concentration-gradients-in-polymer-solar-cell-active-layers
#15
REVIEW
Shusei Inaba, Varun Vohra
Polymer solar cells (PSCs) are considered as one of the most promising low-cost alternatives for renewable energy production with devices now reaching power conversion efficiencies (PCEs) above the milestone value of 10%. These enhanced performances were achieved by developing new electron-donor (ED) and electron-acceptor (EA) materials as well as finding the adequate morphologies in either bulk heterojunction or sequentially deposited active layers. In particular, producing adequate vertical concentration gradients with higher concentrations of ED and EA close to the anode and cathode, respectively, results in an improved charge collection and consequently higher photovoltaic parameters such as the fill factor...
May 9, 2017: Materials
https://www.readbyqxmd.com/read/28772370/simulation-aided-design-of-tubular-polymeric-capsules-for-self-healing-concrete
#16
Branko Šavija, João Feiteira, Maria Araújo, Sutima Chatrabhuti, Jean-Marie Raquez, Kim Van Tittelboom, Elke Gruyaert, Nele De Belie, Erik Schlangen
Polymeric capsules can have an advantage over glass capsules used up to now as proof-of-concept carriers in self-healing concrete. They allow easier processing and afford the possibility to fine tune their mechanical properties. Out of the multiple requirements for capsules used in this context, the capability of rupturing when crossed by a crack in concrete of a typical size is one of the most relevant, as without it no healing agent is released into the crack. This study assessed the fitness of five types of polymeric capsules to fulfill this requirement by using a numerical model to screen the best performing ones and verifying their fitness with experimental methods...
December 24, 2016: Materials
https://www.readbyqxmd.com/read/28769780/automated-functional-analysis-of-astrocytes-from-chronic-time-lapse-calcium-imaging-data
#17
Yinxue Wang, Guilai Shi, David J Miller, Yizhi Wang, Congchao Wang, Gerard Broussard, Yue Wang, Lin Tian, Guoqiang Yu
Recent discoveries that astrocytes exert proactive regulatory effects on neural information processing and that they are deeply involved in normal brain development and disease pathology have stimulated broad interest in understanding astrocyte functional roles in brain circuit. Measuring astrocyte functional status is now technically feasible, due to recent advances in modern microscopy and ultrasensitive cell-type specific genetically encoded Ca(2+) indicators for chronic imaging. However, there is a big gap between the capability of generating large dataset via calcium imaging and the availability of sophisticated analytical tools for decoding the astrocyte function...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28753559/mir-19b-promotes-breast-cancer-metastasis-through-targeting-mylip-and-its-related-cell-adhesion-molecules
#18
Luqing Zhao, Yuelong Zhao, Yanong He, Yitao Mao
miR-19b is a key molecule for cancer development, however its crucial roles in breast cancer metastasis are rarely studied right now. In this study, using several bioinformatics databases to predict the downstream targets for miR-19b, we verified that a novel target gene, myosin regulatory light chain interacting protein (MYLIP), could be directly down-regulated by miR-19b through its 3'-UTR region. MYLIP belongs to the cytoskeletal protein clusters and is involved in the regulation of cell movement and migration...
July 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28749320/reliability-of-heart-rate-mobile-apps-in-young-healthy-adults-exploratory-study-and-research-directions
#19
Maria Parpinel, Laura Scherling, Stefano Lazzer, Vincenzo Della Mea
BACKGROUND: Recently, a number of smartphone apps appeared that allow for heart rate measurements basing on the photoplethysmography principle. In fact, almost every smartphone now has a camera with flash that could be used for that. Some studies appeared on the reliability of some of those apps, with heterogeneous results. OBJECTIVES: The present study aims at adding up evidence in particular during physical activity, by comparing 3 apps on two different platforms (IOs and Android), on a broad range of heart rates...
June 30, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28741602/journal-of-radiological-protection-now-offers-reviewer-recognition-with-publons
#20
Maggie Simmons
No abstract text is available yet for this article.
July 25, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
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