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https://www.readbyqxmd.com/read/28432354/structural-and-functional-analysis-of-lysozyme-after-treatment-with-dielectric-barrier-discharge-plasma-and-atmospheric-pressure-plasma-jet
#1
Sooho Choi, Pankaj Attri, Inhwan Lee, Jeongmin Oh, Ji-Hye Yun, Ji Hoon Park, Eun Ha Choi, Weontae Lee
The variation in the biological function of proteins plays an important role in plasma medicine and sterilization. Several non-thermal plasma sources with different feeding gases are used worldwide for plasma treatment, including dielectric barrier discharge (DBD) and atmospheric-pressure plasma jet (APPJ) as the most commonly used sources. Therefore, in the present work, we used both DBD and APPJ plasma sources with N2 and air as feeding gases to evaluate the effects on the structural, thermodynamic, and activity changes of enzymes...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28431336/beam-induced-back-streaming-electron-suppression-analysis-for-an-accelerator-type-neutron-generator-designed-for-40-ar-39-ar-geochronology
#2
Cory Waltz, Mauricio Ayllon, Tim Becker, Lee Bernstein, Ka-Ngo Leung, Leo Kirsch, Paul Renne, Karl Van Bibber
A facility based on a next-generation, high-flux D-D neutron generator has been commissioned and it is now operational at the University of California, Berkeley. The current generator designed for (40)Ar/(39)Ar dating of geological materials produces nearly monoenergetic 2.45MeV neutrons at outputs of 10(8)n/s. The narrow energy range is advantageous relative to the (235)U fission spectrum neutrons due to (i) reduced (39)Ar recoil energy, (ii) minimized production of interfering argon isotopes from K, Ca, and Cl, and (iii) reduced total activity for radiological safety and waste generation...
April 13, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28429634/migration-of-oligomers-from-pet-determination-of-diffusion-coefficients-and-comparison-of-experimental-versus-modelled-migration
#3
Maria Hoppe, Roberta Fornari, Pim de Voogt, Roland Franz
Polyethylene terephthalate is increasingly used as food contact material for example in containers for beverage such as bottles for soft drinks, mineral water, juices and beer. Mass transport of substances present in packaging materials into the packed food and beverages is monitored to verify the food law compliance of the materials. PET is known to contain or give rise to migrants that are oligomers derived from the polymeric material. Until now their actual migration potential has been investigated only poorly...
April 21, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28411142/pressure-temperature-phase-diagram-of-the-dimorphism-of-the-anti-inflammatory-drug-nimesulide
#4
M Barrio, J Huguet, B Robert, I B Rietveld, R Céolin, J Ll Tamarit
Understanding the phase behavior of active pharmaceutical ingredients is important for formulations of dosage forms and regulatory reasons. Nimesulide is an anti-inflammatory drug that is known to exhibit dimorphism; however up to now its stability behavior was not clear, as few thermodynamic data were available. Therefore, calorimetric melting data have been obtained, which were found to be TI-L=422.4±1.0K, ΔI→LH=117.5±5.2Jg(-1),TII-L=419.8±1.0K and ΔII→LH=108.6±3.3Jg(-1). In addition, vapor-pressure data, high-pressure melting data, and specific volumes have been obtained...
April 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28395223/potassium-compounds-for-gamma-spectrometer-efficiency-verification
#5
E Eren Belgin, G A Aycik
Now-a-days several standard and well calibrated radioactive sources are available for gamma spectrometer efficiency calibration but at some situations, like lack of standard calibrators, in need of verification of standards or preparation a standard with the same properties with the interested sample, (40)K is a cheap and easily available radioisotope that could be used. In this study, eighteen different inorganic potassium compounds that have different potassium abundances, types of elements, densities and particle sizes were studied as efficiency verification sources...
April 5, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28392575/the-cnidome-and-internal-morphology-of-lophelia-pertusa-linnaeus-1758-cnidaria-anthozoa
#6
Susanna M Strömberg, Carina Östman
The cnidome of the scleractinian cold-water coral Lophelia pertusa (Linnaeus, 1758, syn. Lophohelia prolifera) was described by Carlgren in 1940. Due to a renewed interest in the cnidae of L. pertusa, specifically comparisons of adult and larval cnidae and their functions, we now redescribe the cnidome from material collected at the Tisler reef in Norway, close to Carlgren's collection site at Saekken (Sweden). Cnidae from column, tentacles, actinopharynx, mesenterial filaments and acontia were investigated...
April 2017: Acta Zoologica
https://www.readbyqxmd.com/read/28388502/the-bmi-values-of-the-lower-classes-likely-declined-during-the-great-depression
#7
John Komlos, Scott Carson
The BMI values of inmates in the McNeil Island Penitentiary in Washington State declined between the 1860s and the 1910s birth cohorts by 1.44. Furthermore, those who were imprisoned in the 1930s had significantly lower BMI values (by between 0.72 and 1.01) than those who were incarcerated at the end of the 19th century. This corresponds to a decrease in weight of some 2.25kg (4.95lbs) for a man of average height of 173.86cm (68.5inches). The diminution in nutritional status among this lower-class sample is hardly surprising, given the high level of unemployment at the time but has not been verified until now...
March 22, 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/28384329/oxygen-uptake-efficiency-slope-as-a-useful-measure-of-cardiorespiratory-fitness-in-morbidly-obese-women
#8
Tatiana Onofre, Nicole Oliver, Renata Carlos, Amanda Felismino, Renata Cristina Corte, Eliane Silva, Selma Bruno
Cardiopulmonary assessment through oxygen uptake efficiency slope (OUES) data has shown encouraging results, revealing that we can obtain important clinical information about functional status. Until now, the use of OUES has not been established as a measure of cardiorespiratory capacity in an obese adult population, only in cardiac and pulmonary diseases or pediatric patients. The aim of this study was to characterize submaximal and maximal levels of OUES in a sample of morbidly obese women and analyze its relationship with traditional measures of cardiorespiratory fitness, anthropometry and pulmonary function...
2017: PloS One
https://www.readbyqxmd.com/read/28369575/chloroplast-function-revealed-through-analysis-of-greencut2-genes
#9
Rikard Fristedt
Chloroplasts are the green plastids responsible for light-powered photosynthetic reactions and carbon assimilation in the plant cell. Our knowledge of chloroplast functions is constantly increasing and we now know this plastid is predicted to house around 3000 proteins. However, even with generous estimates, we do not know the function of more than 10-15% of these proteins. The next frontier in chloroplast research is to identify and characterize the function of the whole chloroplast proteome, a challenging task due to the inherent complexity a proteome possesses...
March 22, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28366819/direct-detection-of-nano-scale-extracellular-vesicles-derived-from-inflammation-triggered-endothelial-cells-using-surface-plasmon-resonance
#10
Baharak Hosseinkhani, Nynke van den Akker, Jan D'Haen, Mick Gagliardi, Tom Struys, Ivo Lambrichts, Johannes Waltenberger, Inge Nelissen, Jef Hooyberghs, Daniel G M Molin, Luc Michiels
A major conceptual breakthrough in cell signaling has been the finding of EV as new biomarker shuttles in body fluids. Now, one of the major challenges in using these nanometer-sized biological entities as diagnostic marker is the development of translational methodologies to profile them. SPR offers a promising label-free and real time platform with a high potential for biomarker detection. Therefore, we aimed to develop a uniform SPR methodology to detect specific surface markers on EV derived from patient with CHD...
March 30, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28358842/the-risk-of-clopidogrel-resistance-is-associated-with-abcb1-polymorphisms-but-not-promoter-methylation-in-a-chinese-han-population
#11
Jia Su, Qinglin Yu, Hao Zhu, Xiaojing Li, Hanbin Cui, Weiping Du, Lindan Ji, Maoqing Tong, Yibo Zheng, Hongyu Xu, Jianjiang Zhang, Yunyun Zhu, Yezi Xia, Ting Liu, Qi Yao, Jun Yang, Xiaomin Chen, Jingbo Yu
The goal of our study was to investigate the contribution of ABCB1 expression to the risk of clopidogrel resistance (CR). Platelets functions were measured using the Verify-Now P2Y12 assay. Applying Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP), the single-nucleotide polymorphisms (SNPs) was tested. Using bisulphite pyrosequencing assay, we investigated the association of the ABCB1 DNA methylation levels and CR. It was shown that female, hypertension, and lower albumin levels increased the risk of CR (P<0...
2017: PloS One
https://www.readbyqxmd.com/read/28357402/copar-a-chip-seq-optimal-peak-analyzer
#12
Binhua Tang, Xihan Wang, Victor X Jin
Sequencing data quality and peak alignment efficiency of ChIP-sequencing profiles are directly related to the reliability and reproducibility of NGS experiments. Till now, there is no tool specifically designed for optimal peak alignment estimation and quality-related genomic feature extraction for ChIP-sequencing profiles. We developed open-sourced COPAR, a user-friendly package, to statistically investigate, quantify, and visualize the optimal peak alignment and inherent genomic features using ChIP-seq data from NGS experiments...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28353333/tomographic-mapping-analysis-in-the-depth-direction-of-high-ge-content-sige-layers-with-compositionally-graded-buffers-using-nanobeam-x-ray-diffraction
#13
Kazuki Shida, Shotaro Takeuchi, Yasuhiko Imai, Shigeru Kimura, Andreas Schulze, Matty Caymax, Akira Sakai
A high-Ge-content Si1-yGey/compositionally graded Si1-xGex-stacked structure grown on Si(001) is now considered to be an important platform for the realization of advanced nanometer-scale complementary metal oxide semiconductor devices with high-mobility channel materials, such as III-V materials and Ge, and monolithically integrated photonic modules. The performance of such advanced devices is critically influenced by crystalline inhomogeneity in the stacked structure; therefore, precise characterization of the crystallinity is important...
April 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28343147/ethical-ramifications-of-the-paolo-macchiarini-case
#14
Jaime A Teixeira da Silva
The Paolo Macchiarini case has several ethical ramifications. Professor Macchiarini, formerly of the Karolinska Institutet (KI), became famous for the tracheal surgeries he conducted between 2008 and 2014. His rapid rise to fame was followed by an almost equally rapid fall from grace as official reports, articles in newspapers and television programmes revealed several aspects related to misconduct in his curriculum vitae, professional practices and publishing-related activity. Formal misconduct reports issued by four KI co-workers in late 2014, then again in 2016, coupled with social scandals, including the tricking of a famous US television newscaster into a false marriage, a previous arrest in Italy for apparent bribery, and acute narcissism, all tainted Macchiarini's legend...
March 15, 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28337682/three-members-of-opisthomonorcheides-parukhin-1966-digenea-monorchiidae-from-carangid-fishes-perciformes-from-indonesia-with-a-review-of-the-genus
#15
Rodney A Bray, Harry W Palm, Scott C Cutmore, Thomas H Cribb
Three species of Opisthomonorcheides Parukhin, 1966 are reported for the first time from Indonesian waters: O. pampi (Wang, 1982) Liu, Peng, Gao, Fu, Wu, Lu, Gao & Xiao, 2010 and O. ovacutus (Mamaev, 1970) Machida, 2011 from Parastromateus niger (Bloch), and O. decapteri Parukhin, 1966 from Atule mate (Cuvier). Both O. pampi and O. ovacutus can now be considered widespread in the Indo-Pacific region, with earlier records of these species being from Fujian Province, China and Penang, Malaysia, respectively. We redescribe O...
March 23, 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28333906/-phonosurgery-treatment-options-in-male-to-female-and-female-to-male-transsexuals
#16
Bożena Kosztyła-Hojna, Greta Berger, Vitaly Gryniewicz, Eugeniusz Tarasów
The voice is an important part of human identity. The voice is susceptible to impact of hormons mainly sexual hormons. The larynx is one of secondary sex characacteristics. Disorders of voice pose serious obstacle to full social integration in male to female and female to male transsexuals. The causes of transsexuality are still a matter of considerable debate. Now it is considered that, big nucleus suprachiasmaticus in the hypothalamus may be a cause of transsexuality. The aim of phonosurgery in transsexual patients is to gain acceptable voice by the patients...
March 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28316341/ground-based-measurements-of-the-1-3-to-0-3-millimeter-spectrum-of-jupiter-and-saturn-and-their-detailed-calibration
#17
Juan R Pardo, Eugene Serabyn, Martina C Wiedner, Raphäel Moreno, Glenn Orton
One of the legacies of the now retired Caltech Submillimeter Observatory (CSO) is presented in this paper. We measured for the first time the emission of the giant planets Jupiter and Saturn across the 0.3 to 1.3 mm wavelength range using a Fourier Transform Spectrometer mounted on the 10.4-meter dish of the CSO at Mauna Kea, Hawaii, 4100 meters above sea level. A careful calibration, including the evaluation of the antenna performance over such a wide wavelength range and the removal of the Earth's atmosphere effects, has allowed the detection of broad absorption lines on those planets' atmospheres...
July 1, 2017: Icarus
https://www.readbyqxmd.com/read/28303290/relationship-between-functional%C3%A2-endoscopy%C3%A2-and-impedance-ph%C3%A2-measurement
#18
F Michel, T Stroh, R Fritsche, P Ahrens
Classic gastroenterological diagnostic tools have proven to be insufficient in identifying the causal relationship between extra-esophageal symptoms and presumed pathological reflux activity. Some new methodological approaches, such as functional endoscopy (video panendoscopy, VPE), are considered to be helpful. However, there are currently no data objectively verifying the success of this method. In a previous study, we found a good correlation between the reflux symptom index (RSI) according to Belafsky and endoscopic findings...
March 16, 2017: HNO
https://www.readbyqxmd.com/read/28290613/selection-of-experimental-strawberry-fragaria-x-ananassa-hybrids-based-on-selection-indices
#19
S D Vieira, D C de Souza, I A Martins, G H M R Ribeiro, L V Resende, A K L Ferraz, A G Galvão, J T V de Resende
The strawberry (Fragaria x ananassa Dutch.), is the only vegetable belonging to the rosacea family. All strawberry species have now emerged from wild species and belong to the genus Fragaria, being that this genus presents more than 45 described species, and only 11 are considered natural species. Due to the octoploid nature of strawberry and its variability after hybridization, selecting one or more characters may result in unfavorable genotypes and even the exclusion of promising ones, because negative genetic correlations have been observed among them that cause inefficient selection...
March 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28283555/developmental-genetic-dietary-and-xenobiotic-influences-on-neonatal-hyperbilirubinemia
#20
REVIEW
Mei-Fei Yueh, Shujuan Chen, Nghia Nguyen, Robert H Tukey
Hyperbilirubinemia, caused by the accumulation of unconjugated bilirubin, is one of the most common clinical diagnoses in both premature and term newborns. Owing to the fact that bilirubin is metabolized solely through glucuronidation by UDP-glucuronosyltransferase (UGT) 1A1, it is now known that immaturity of UGT1A1, in combination with the overproduction of bilirubin during the developmental stage, acts as a bottleneck to bilirubin elimination and predisposes the infant to high total serum bilirubin levels...
May 2017: Molecular Pharmacology
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