keyword
MENU ▼
Read by QxMD icon Read
search

Verify now

keyword
https://www.readbyqxmd.com/read/28520845/follow-up-of-a-large-prospective-united-states-cohort-by-linkage-with-multiple-state-cancer-registries
#1
Eric J Jacobs, Peter J Briggs, Anusila Deka, Christina C Newton, Kevin C Ward, Betsy A Kohler, Susan M Gapstur, Alpa V Patel
All states in the United States now have a well-established cancer registry. Linkage with these registries may be a cost-effective method of follow-up for cancer incidence in multi-state cohort studies. However, the sensitivity of linkage with the current network of state registries for detecting incident cancer diagnoses within cohort studies is not well-documented. We examined the sensitivity of registry linkage among 39,368 men and women from 23 states who enrolled in the Cancer Prevention Study-3 cohort from 2006-2009 and had the opportunity to self-report cancer diagnoses on a questionnaire in 2011...
May 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28511651/high-resolution-mucociliary-transport-measurement-in-live-excised-large-animal-trachea-using-synchrotron-x-ray-imaging
#2
Martin Donnelley, Kaye S Morgan, Maged Awadalla, Nigel R Farrow, Chris Hall, David W Parsons
BACKGROUND: The Australian Synchrotron Imaging and Medical Beamline (IMBL) was designed as the world's widest synchrotron X-ray beam, enabling both clinical imaging and therapeutic applications for humans as well as the imaging of large animal models. Our group is developing methods for imaging the airways of newly developed CF animal models that display human-like lung disease, such as the CF pig, and we expect that the IMBL can be utilised to image airways in animals of this size. METHODS: This study utilised samples of excised tracheal tissue to assess the feasibility, logistics and protocols required for airway imaging in large animal models such as pigs and sheep at the IMBL...
May 16, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28507680/an-albumin-based-tumor-targeted-oxaliplatin-prodrug-with-distinctly-improved-anticancer-activity-in-vivo
#3
Josef Mayr, Petra Heffeter, Diana Groza, Luis Galvez, Gunda Koellensperger, Alexander Roller, Beatrix Alte, Melanie Haider, Walter Berger, Christian R Kowol, Bernhard K Keppler
The design of targeted platinum(iv) prodrugs is a very promising approach to enhance the low selectivity of platinum(ii) drugs towards cancerous tissue in order to reduce the impact on healthy tissue and, consequently, the often severe side-effects. Herein, we report a set of mono-functionalized cis- and oxaliplatin-based platinum(iv) complexes bearing a maleimide moiety, which allows selective binding to serum albumin in the bloodstream. This leads not only to a prolonged plasma half-life by avoidance of fast renal clearance, but also to preferential accumulation of the drug in the tumor tissue due to the EPR-effect...
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28483832/screening-for-atrial-fibrillation-a-report-of-the-af-screen-international-collaboration
#4
REVIEW
Ben Freedman, John Camm, Hugh Calkins, Jeffrey S Healey, Mårten Rosenqvist, Jiguang Wang, Christine M Albert, Craig S Anderson, Sotiris Antoniou, Emelia J Benjamin, Giuseppe Boriani, Johannes Brachmann, Axel Brandes, Tze-Fan Chao, David Conen, Johan Engdahl, Laurent Fauchier, David A Fitzmaurice, Leif Friberg, Bernard J Gersh, David J Gladstone, Taya V Glotzer, Kylie Gwynne, Graeme J Hankey, Joseph Harbison, Graham S Hillis, Mellanie T Hills, Hooman Kamel, Paulus Kirchhof, Peter R Kowey, Derk Krieger, Vivian W Y Lee, Lars-Åke Levin, Gregory Y H Lip, Trudie Lobban, Nicole Lowres, Georges H Mairesse, Carlos Martinez, Lis Neubeck, Jessica Orchard, Jonathan P Piccini, Katrina Poppe, Tatjana S Potpara, Helmut Puererfellner, Michiel Rienstra, Roopinder K Sandhu, Renate B Schnabel, Chung-Wah Siu, Steven Steinhubl, Jesper H Svendsen, Emma Svennberg, Sakis Themistoclakis, Robert G Tieleman, Mintu P Turakhia, Arnljot Tveit, Steven B Uittenbogaart, Isabelle C Van Gelder, Atul Verma, Rolf Wachter, Bryan P Yan
Approximately 10% of ischemic strokes are associated with atrial fibrillation (AF) first diagnosed at the time of stroke. Detecting asymptomatic AF would provide an opportunity to prevent these strokes by instituting appropriate anticoagulation. The AF-SCREEN international collaboration was formed in September 2015 to promote discussion and research about AF screening as a strategy to reduce stroke and death and to provide advocacy for implementation of country-specific AF screening programs. During 2016, 60 expert members of AF-SCREEN, including physicians, nurses, allied health professionals, health economists, and patient advocates, were invited to prepare sections of a draft document...
May 9, 2017: Circulation
https://www.readbyqxmd.com/read/28470438/a-novel-physical-colonoscopy-simulator-based-on-analysis-of-data-from-computed-tomography-colonography
#5
Katsuhisa Noda, Takatoshi Kitada, Yasumoto Suzuki, Hugh Shunsuke Colvin, Taishi Hata, Tsunekazu Mizushima
PURPOSE: Laparoscopic surgery is now practiced widely because of its lower postoperative morbidity. As flexible endoscopy during laparoscopic surgery minimizes surgical trauma further, training in endoscopy will become more important for surgeons. Thus, we designed a physical simulator, the Noda-Kitada-Suzuki (NKS) model, which could provide the more realistic insertion of a colonoscope. METHODS: We designed a colonoscopy simulator, based on information from computed tomography colonography scans of the anatomy and kinetic properties of the colon and rectum...
May 3, 2017: Surgery Today
https://www.readbyqxmd.com/read/28467154/how-do-people-who-frequently-attend-emergency-departments-for-alcohol-related-reasons-use-view-and-experience-specialist-addiction-services
#6
Thomas Parkman, Joanne Neale, Ed Day, Colin Drummond
BACKGROUND: People who frequently attend emergency departments (EDs) for alcohol-related reasons, cost health systems greatly. Although specialist addiction services may be more appropriate for their needs, drinkers often experience barriers accessing specialist alcohol-related support. OBJECTIVES: This study explores how people who frequently attend EDs for alcohol-related reasons use, view, and experience specialist addiction services. METHODS: We conducted semi-structured interviews with 30 individuals recruited from six EDs across London, United Kingdom...
May 3, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28464822/a-high-quality-assembly-of-the-nile-tilapia-oreochromis-niloticus-genome-reveals-the-structure-of-two-sex-determination-regions
#7
Matthew A Conte, William J Gammerdinger, Kerry L Bartie, David J Penman, Thomas D Kocher
BACKGROUND: Tilapias are the second most farmed fishes in the world and a sustainable source of food. Like many other fish, tilapias are sexually dimorphic and sex is a commercially important trait in these fish. In this study, we developed a significantly improved assembly of the tilapia genome using the latest genome sequencing methods and show how it improves the characterization of two sex determination regions in two tilapia species. RESULTS: A homozygous clonal XX female Nile tilapia (Oreochromis niloticus) was sequenced to 44X coverage using Pacific Biosciences (PacBio) SMRT sequencing...
May 2, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28450155/ionised-concentrations-in-calcium-and-magnesium-buffers-standards-and-precise-measurement-are-mandatory
#8
John A S McGuigan, James W Kay, Hugh Y Elder
In Ca(2+) and Mg(2+) buffer solutions the ionised concentrations ([X(2+)]) are either calculated or measured. Calculated values vary by up to a factor of seven due to the following four problems: The calculated [X(2+)] in buffers are so inconsistent that calculation is not an option. Until standards are available, the [X(2+)] in the buffers must be measured. The Ligand Optimisation Method is an accurate and independently verified method of doing this (McGuigan & Stumpff, Anal. Biochem. 436, 29, 2013). Lack of standards means it is not possible to compare the published [Ca(2+)] in the nmolar range, and the apparent constant (K(/)) values for Ca(2+) and Mg(2+) binding to intracellular ligands amongst different laboratories...
April 24, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28432354/structural-and-functional-analysis-of-lysozyme-after-treatment-with-dielectric-barrier-discharge-plasma-and-atmospheric-pressure-plasma-jet
#9
Sooho Choi, Pankaj Attri, Inhwan Lee, Jeongmin Oh, Ji-Hye Yun, Ji Hoon Park, Eun Ha Choi, Weontae Lee
The variation in the biological function of proteins plays an important role in plasma medicine and sterilization. Several non-thermal plasma sources with different feeding gases are used worldwide for plasma treatment, including dielectric barrier discharge (DBD) and atmospheric-pressure plasma jet (APPJ) as the most commonly used sources. Therefore, in the present work, we used both DBD and APPJ plasma sources with N2 and air as feeding gases to evaluate the effects on the structural, thermodynamic, and activity changes of enzymes...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28431336/beam-induced-back-streaming-electron-suppression-analysis-for-an-accelerator-type-neutron-generator-designed-for-40-ar-39-ar-geochronology
#10
Cory Waltz, Mauricio Ayllon, Tim Becker, Lee Bernstein, Ka-Ngo Leung, Leo Kirsch, Paul Renne, Karl Van Bibber
A facility based on a next-generation, high-flux D-D neutron generator has been commissioned and it is now operational at the University of California, Berkeley. The current generator designed for (40)Ar/(39)Ar dating of geological materials produces nearly monoenergetic 2.45MeV neutrons at outputs of 10(8)n/s. The narrow energy range is advantageous relative to the (235)U fission spectrum neutrons due to (i) reduced (39)Ar recoil energy, (ii) minimized production of interfering argon isotopes from K, Ca, and Cl, and (iii) reduced total activity for radiological safety and waste generation...
April 13, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28429634/migration-of-oligomers-from-pet-determination-of-diffusion-coefficients-and-comparison-of-experimental-versus-modelled-migration
#11
Maria Hoppe, Roberta Fornari, Pim de Voogt, Roland Franz
Polyethylene terephthalate is increasingly used as food contact material for example in containers for beverage such as bottles for soft drinks, mineral water, juices and beer. Mass transport of substances present in packaging materials into the packed food and beverages is monitored to verify the food law compliance of the materials. PET is known to contain or give rise to migrants that are oligomers derived from the polymeric material. Until now their actual migration potential has been investigated only poorly...
April 21, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28411142/pressure-temperature-phase-diagram-of-the-dimorphism-of-the-anti-inflammatory-drug-nimesulide
#12
M Barrio, J Huguet, B Robert, I B Rietveld, R Céolin, J Ll Tamarit
Understanding the phase behavior of active pharmaceutical ingredients is important for formulations of dosage forms and regulatory reasons. Nimesulide is an anti-inflammatory drug that is known to exhibit dimorphism; however up to now its stability behavior was not clear, as few thermodynamic data were available. Therefore, calorimetric melting data have been obtained, which were found to be TI-L=422.4±1.0K, ΔI→LH=117.5±5.2Jg(-1),TII-L=419.8±1.0K and ΔII→LH=108.6±3.3Jg(-1). In addition, vapor-pressure data, high-pressure melting data, and specific volumes have been obtained...
April 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28395223/potassium-compounds-for-gamma-spectrometer-efficiency-verification
#13
E Eren Belgin, G A Aycik
Now-a-days several standard and well calibrated radioactive sources are available for gamma spectrometer efficiency calibration but at some situations, like lack of standard calibrators, in need of verification of standards or preparation a standard with the same properties with the interested sample, (40)K is a cheap and easily available radioisotope that could be used. In this study, eighteen different inorganic potassium compounds that have different potassium abundances, types of elements, densities and particle sizes were studied as efficiency verification sources...
April 5, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28392575/the-cnidome-and-internal-morphology-of-lophelia-pertusa-linnaeus-1758-cnidaria-anthozoa
#14
Susanna M Strömberg, Carina Östman
The cnidome of the scleractinian cold-water coral Lophelia pertusa (Linnaeus, 1758, syn. Lophohelia prolifera) was described by Carlgren in 1940. Due to a renewed interest in the cnidae of L. pertusa, specifically comparisons of adult and larval cnidae and their functions, we now redescribe the cnidome from material collected at the Tisler reef in Norway, close to Carlgren's collection site at Saekken (Sweden). Cnidae from column, tentacles, actinopharynx, mesenterial filaments and acontia were investigated...
April 2017: Acta Zoologica
https://www.readbyqxmd.com/read/28388502/the-bmi-values-of-the-lower-classes-likely-declined-during-the-great-depression
#15
John Komlos, Scott Carson
The BMI values of inmates in the McNeil Island Penitentiary in Washington State declined between the 1860s and the 1910s birth cohorts by 1.44. Furthermore, those who were imprisoned in the 1930s had significantly lower BMI values (by between 0.72 and 1.01) than those who were incarcerated at the end of the 19th century. This corresponds to a decrease in weight of some 2.25kg (4.95lbs) for a man of average height of 173.86cm (68.5inches). The diminution in nutritional status among this lower-class sample is hardly surprising, given the high level of unemployment at the time but has not been verified until now...
March 22, 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/28384329/oxygen-uptake-efficiency-slope-as-a-useful-measure-of-cardiorespiratory-fitness-in-morbidly-obese-women
#16
Tatiana Onofre, Nicole Oliver, Renata Carlos, Amanda Felismino, Renata Cristina Corte, Eliane Silva, Selma Bruno
Cardiopulmonary assessment through oxygen uptake efficiency slope (OUES) data has shown encouraging results, revealing that we can obtain important clinical information about functional status. Until now, the use of OUES has not been established as a measure of cardiorespiratory capacity in an obese adult population, only in cardiac and pulmonary diseases or pediatric patients. The aim of this study was to characterize submaximal and maximal levels of OUES in a sample of morbidly obese women and analyze its relationship with traditional measures of cardiorespiratory fitness, anthropometry and pulmonary function...
2017: PloS One
https://www.readbyqxmd.com/read/28369575/chloroplast-function-revealed-through-analysis-of-greencut2-genes
#17
Rikard Fristedt
Chloroplasts are the green plastids responsible for light-powered photosynthetic reactions and carbon assimilation in the plant cell. Our knowledge of chloroplast functions is constantly increasing and we now know this plastid is predicted to house around 3000 proteins. However, even with generous estimates, we do not know the function of more than 10-15% of these proteins. The next frontier in chloroplast research is to identify and characterize the function of the whole chloroplast proteome, a challenging task due to the inherent complexity a proteome possesses...
March 22, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28366819/direct-detection-of-nano-scale-extracellular-vesicles-derived-from-inflammation-triggered-endothelial-cells-using-surface-plasmon-resonance
#18
Baharak Hosseinkhani, Nynke van den Akker, Jan D'Haen, Mick Gagliardi, Tom Struys, Ivo Lambrichts, Johannes Waltenberger, Inge Nelissen, Jef Hooyberghs, Daniel G M Molin, Luc Michiels
A major conceptual breakthrough in cell signaling has been the finding of EV as new biomarker shuttles in body fluids. Now, one of the major challenges in using these nanometer-sized biological entities as diagnostic marker is the development of translational methodologies to profile them. SPR offers a promising label-free and real time platform with a high potential for biomarker detection. Therefore, we aimed to develop a uniform SPR methodology to detect specific surface markers on EV derived from patient with CHD...
March 30, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28358842/the-risk-of-clopidogrel-resistance-is-associated-with-abcb1-polymorphisms-but-not-promoter-methylation-in-a-chinese-han-population
#19
Jia Su, Qinglin Yu, Hao Zhu, Xiaojing Li, Hanbin Cui, Weiping Du, Lindan Ji, Maoqing Tong, Yibo Zheng, Hongyu Xu, Jianjiang Zhang, Yunyun Zhu, Yezi Xia, Ting Liu, Qi Yao, Jun Yang, Xiaomin Chen, Jingbo Yu
The goal of our study was to investigate the contribution of ABCB1 expression to the risk of clopidogrel resistance (CR). Platelets functions were measured using the Verify-Now P2Y12 assay. Applying Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP), the single-nucleotide polymorphisms (SNPs) was tested. Using bisulphite pyrosequencing assay, we investigated the association of the ABCB1 DNA methylation levels and CR. It was shown that female, hypertension, and lower albumin levels increased the risk of CR (P<0...
2017: PloS One
https://www.readbyqxmd.com/read/28357402/copar-a-chip-seq-optimal-peak-analyzer
#20
Binhua Tang, Xihan Wang, Victor X Jin
Sequencing data quality and peak alignment efficiency of ChIP-sequencing profiles are directly related to the reliability and reproducibility of NGS experiments. Till now, there is no tool specifically designed for optimal peak alignment estimation and quality-related genomic feature extraction for ChIP-sequencing profiles. We developed open-sourced COPAR, a user-friendly package, to statistically investigate, quantify, and visualize the optimal peak alignment and inherent genomic features using ChIP-seq data from NGS experiments...
2017: BioMed Research International
keyword
keyword
39782
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"