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Microglia process length skeleton

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https://www.readbyqxmd.com/read/29038483/quantitative-microglia-analyses-reveal-diverse-morphologic-responses-in-the-rat-cortex-after-diffuse-brain-injury
#1
Helena Morrison, Kimberly Young, Mahir Qureshi, Rachel K Rowe, Jonathan Lifshitz
Determining regions of altered brain physiology after diffuse brain injury is challenging. Microglia, brain immune cells with ramified and dynamically moving processes, constantly surveil the parenchyma for dysfunction which, when present, results in a changed morphology. Our purpose was to define the spatiotemporal changes in microglia morphology over 28 days following rat midline fluid percussion injury (mFPI) as a first step in exploiting microglia morphology to reflect altered brain physiology. Microglia morphology was quantified from histological sections using Image J skeleton and fractal analysis procedures at three time points and in three regions post-mFPI: impact site, primary somatosensory cortex barrel field (S1BF), and a remote region...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28270592/evidence-that-remodeling-of-insular-cortex-neurovascular-unit-contributes-to-hypertension-related-sympathoexcitation
#2
Fernanda R Marins, Jennifer A Iddings, Marco A P Fontes, Jessica A Filosa
The intermediate region of the posterior insular cortex (intermediate IC) mediates sympathoexcitatory responses to the heart and kidneys. Previous studies support hypertension-evoked changes to the structure and function of neurons, blood vessels, astrocytes and microglia, disrupting the organization of the neurovascular unit (NVU). In this study, we evaluated the functional and anatomical integrity of the NVU at the intermediate IC in the spontaneously hypertensive rat (SHR) and its control the Wistar-Kyoto (WKY)...
March 2017: Physiological Reports
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