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https://www.readbyqxmd.com/read/28153785/aortic-and-splanchnic-artery-aneurysms-unusual-causes-of-biliary-obstruction-a-retrospective-cohort-from-literature
#1
REVIEW
Kevin Tin, Zain A Sobani, Joel Horovitz, Rabin Rahmani
Mechanical obstruction of the biliary tree and resultant stasis are the cornerstone of a spectrum of diseases ranging from biliary colic to fulminant cholangitis. Infrequently acquired abnormalities of the abdominal vasculature can lead to biliary obstruction. In 2010, we reported a case of acute cholangitis resulting from compression of extra hepatic bile duct by an abdominal aortic aneurysm (AAA). We subsequently conducted a follow up scoping review of literature to identify other cases of acquired abdominal arterial abnormalities resulting in biliary obstruction looking at their management and outcomes...
January 30, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28120135/extraperitoneal-vs-transperitoneal-robot-assisted-radical-prostatectomy-in-patients-with-a-history-of-prior-inguinal-hernia-repair-with-mesh
#2
David Horovitz, Changyong Feng, Edward M Messing, Jean V Joseph
Robot-assisted radical prostatectomy (RARP) may be performed via an extraperitoneal (eRARP) or transperitoneal (tRARP) approach. There are no published studies comparing these two methods in patients with a history of prior inguinal hernia repair with mesh (IHRm), but the latter is often advocated in this setting. A retrospective review of patients who underwent RARP with prior IHRm who had a minimum follow-up of 3 months from July 1, 2003 to December 31, 2014 was undertaken. Of 2927 patients who underwent RARP for primary treatment of adenocarcinoma of the prostate, 286 patients had a clear history of IHRm...
January 24, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28116232/changes-in-functional-organization-and-white-matter-integrity-in-the-connectome-in-parkinson-s-disease
#3
Sule Tinaz, Peter M Lauro, Pritha Ghosh, Codrin Lungu, Silvina G Horovitz
Parkinson's disease (PD) leads to dysfunction in multiple cortico-striatal circuits. The neurodegeneration has also been associated with impaired white matter integrity. This structural and functional "disconnection" in PD needs further characterization. We investigated the structural and functional organization of the PD whole brain connectome consisting of 200 nodes using diffusion tensor imaging and resting-state functional MRI, respectively. Data from 20 non-demented PD patients on dopaminergic medication and 20 matched controls were analyzed using graph theory-based methods...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28073298/extraperitoneal-vs-transperitoneal-robot-assisted-radical-prostatectomy-in-the-setting-of-prior-abdominal-or-pelvic-surgery
#4
David Horovitz, Changyong Feng, Edward M Messing, Jean Volny Joseph
INTRODUCTION: During Robotic-Assisted Radical Prostatectomy (RARP), the prostate may be approached extraperiteoneally (eRARP) or transperitoneally (tRARP). The former avoids the abdominal cavity which might be of benefit in patients who have had prior abdominal or pelvic surgery (PAPS). Our objective was to compare the outcomes of patients with PAPS undergoing either technique. METHODS: A retrospective review of patients treated with RARP from July 1, 2003-Dec. 31, 2014 with a minimum follow-up of 3 months was undertaken...
January 10, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28060550/evaluating-platelet-function-disorders-in-children-with-bleeding-tendency-a-single-center-study
#5
Osama Tanous, Orna Steinberg Shemer, Joanne Yacobovich, Meira Zoldan, Yoseph Horovitz, Isaac Yaniv, Esther Rabizadeh, Hannah Tamary, Sigal Nakav, Judith Lahav
Platelet function disorders (PFDs) are a common cause of mild bleeding tendency. However, they cannot be recognized by standard screening studies. The gold standard test for PFD is platelet aggregation, performed by light transmission aggregometry (LTA). A newer and less validated method is the closure time (CT), performed by the platelet function Analyzer 100 (PFA-100). Data regarding the validity of these tests in children are limited. The aim of this study was to evaluate the usefulness of LTA and PFA-100 for the diagnosis of pediatric patients with bleeding tendency...
January 6, 2017: Platelets
https://www.readbyqxmd.com/read/27709275/-impairment-of-oxygenation-of-patients-in-surgical-intensive-care-early-symptom-of-severe-sepsis
#6
M Hückstädt, G O Hofmann, T Mendel, R Stuttmann, P Hilbert-Carius
BACKGROUND: Sepsis and septic shock are major contributors to morbidity and mortality in intensive care patients. Early identification and adequate therapy are of utmost importance to reduce the still high mortality in patients with severe sepsis. Many of the pathophysiologic changes are nonspecific. Thus, a combination of symptoms and laboratory results are necessary to confirm the diagnosis. Impairment of the Horovitz index is identified as being a primal prognostic criterion for early diagnosis in serious progression of sepsis, after exclusion of a few differential diagnoses...
November 2016: Der Anaesthesist
https://www.readbyqxmd.com/read/27686496/transient-kinetic-analysis-of-atp-hydrolysis-by-the-cct-tric-chaperonin
#7
Ilia Korobko, Michal Nadler-Holly, Amnon Horovitz
The chaperonin-containing t-complex polypeptide 1 (CCT, also known as TRiC) assists protein folding in an ATP-dependent manner. CCT/TRiC was mixed rapidly with different concentrations of ATP, and the amount of phosphate formed upon ATP hydrolysis was measured as a function of time using the coumarin-labeled phosphate-binding protein method. Two burst phases were observed, followed by a lag phase and then a linear steady-state phase of ATP hydrolysis. The phases were assigned by (i) determining their dependence on ATP and K(+) concentrations and (ii) by measuring their sensitivity to the mutation Gly345→Asp in subunit CCT4, which decreases cooperativity in ATP binding...
September 26, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27634356/gabaergic-synapses-at-the-axon-initial-segment-of-basolateral-amygdala-projection-neurons-modulate-fear-extinction
#8
Rinki Saha, Stephanie Knapp, Darpan Chakraborty, Omer Horovitz, Anne Albrecht, Martin Kriebel, Hanoch Kaphzan, Ingrid Ehrlich, Hansjürgen Volkmer, Gal Richter-Levin
Inhibitory synaptic transmission in the amygdala has a pivotal role in fear learning and its extinction. However, the local circuits formed by GABAergic inhibitory interneurons within the amygdala and their detailed function in shaping these behaviors are not well understood. Here we used lentiviral-mediated knockdown of the cell adhesion molecule neurofascin in the basolateral amygdala (BLA) to specifically remove inhibitory synapses at the axon initial segment (AIS) of BLA projection neurons. Quantitative analysis of GABAergic synapse markers and measurement of miniature inhibitory postsynaptic currents in BLA projection neurons after neurofascin knockdown ex vivo confirmed the loss of GABAergic input...
January 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27498540/erratum-to-alg6-cdg-a-recognizable-phenotype-with-epilepsy-proximal-muscle-weakness-ataxia-and-behavioral-and-limb-anomalies
#9
Eva Morava, Vera Tiemes, Christian Thiel, Nathalie Seta, Pascale de Lonlay, Hans de Klerk, Margot Mulder, Estela Rubio-Gozalbo, Gepke Visser, Peter van Hasselt, Dafne D G Horovitz, Carolina Fischinger Moura de Souza, Ida V D Schwartz, Andrew Green, Mohammed Al-Owain, Graciella Uziel, Sabine Sigaudy, Brigitte Chabrol, Franc-Jan van Spronsen, Martin Steinert, Eleni Komini, Donald Wurm, Andrea Bevot, Addelkarim Ayadi, Karin Huijben, Marli Dercksen, Peter Witters, Jaak Jaeken, Gert Matthijs, Dirk J Lefeber, Ron A Wevers
No abstract text is available yet for this article.
September 2016: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/27466043/impairment-of-a-parieto-premotor-network-specialized-for-handwriting-in-writer-s-cramp
#10
Cecile Gallea, Silvina G Horovitz, Muslimah 'Ali Najee-Ullah, Mark Hallett
Handwriting with the dominant hand is a highly skilled task singularly acquired in humans. This skill is the isolated deficit in patients with writer's cramp (WC), a form of dystonia with maladaptive plasticity, acquired through intensive and repetitive motor practice. When a skill is highly trained, a motor program is created in the brain to execute the same movement kinematics regardless of the effector used for the task. The task- and effector-specific symptoms in WC suggest that a problem particularly occurs in the brain when the writing motor program is carried out by the dominant hand...
December 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27405707/receptor-tyrosine-kinase-epha7-is-required-for-interneuron-connectivity-at-specific-subcellular-compartments-of-granule-cells
#11
Simone Beuter, Ziv Ardi, Omer Horovitz, Jennifer Wuchter, Stefanie Keller, Rinki Saha, Kuldeep Tripathi, Rachel Anunu, Orli Kehat, Martin Kriebel, Gal Richter-Levin, Hansjürgen Volkmer
Neuronal transmission is regulated by the local circuitry which is composed of principal neurons targeted at different subcellular compartments by a variety of interneurons. However, mechanisms that contribute to the subcellular localisation and maintenance of GABAergic interneuron terminals are poorly understood. Stabilization of GABAergic synapses depends on clustering of the postsynaptic scaffolding protein gephyrin and its interaction with the guanine nucleotide exchange factor collybistin. Lentiviral knockdown experiments in adult rats indicated that the receptor tyrosine kinase EphA7 is required for the stabilisation of basket cell terminals on proximal dendritic and somatic compartments of granular cells of the dentate gyrus...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27385746/impaired-self-agency-in-functional-movement-disorders-a-resting-state-fmri-study
#12
Carine W Maurer, Kathrin LaFaver, Rezvan Ameli, Steven A Epstein, Mark Hallett, Silvina G Horovitz
OBJECTIVE: To investigate the neural mechanisms underlying impaired self-agency in patients with functional movement disorders using resting-state functional MRI (fMRI). METHODS: We obtained resting-state fMRI on 35 patients with clinically definite functional movement disorders and 35 age- and sex-matched healthy controls. Between-group differences in functional connectivity from the right temporo-parietal junction (TPJ), a region previously demonstrated to play a critical role in self-agency by comparing internal predictions of movement with actual external events, were assessed using t tests...
August 9, 2016: Neurology
https://www.readbyqxmd.com/read/27378805/cranial-bone-collapse-in-microcephalic-infants-prenatally-exposed-to-zika-virus-infection
#13
Dafne Dain Gandelman Horovitz, Marcos Vinicius da Silva Pone, Sheila Moura Pone, Tania Regina Dias Saad Salles, Marcia Cristina Bastos Boechat
No abstract text is available yet for this article.
July 5, 2016: Neurology
https://www.readbyqxmd.com/read/27310037/diagnosis-of-familial-mediterranean-fever-following-the-initial-presentation-of-monoarthritis
#14
Yoseph Horovitz, Osama Tanous, Morad Khayat, Munir Shaker, Stavit Shalev, Ronen Spiegel
AIMS: To determine if familial Mediterranean fever (FMF) genetic testing should be advised in children with initial presentation of monoarthritis and to identify clinical parameters associated with FMF-induced arthritis that warrant genetic investigation. METHODS: A prospective study of 71 otherwise healthy children admitted to our pediatric department between 2010-2013 with a first episode of idiopathic monoarthritis. Demographic, clinical and laboratory data were documented and genetic assay of the five common mutations in our population of the MEFV gene that cause FMF syndrome were analyzed in the entire study population...
June 16, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/27129473/alternative-laronidase-dose-regimen-for-patients-with-mucopolysaccharidosis-i-a-multinational-retrospective-chart-review-case-series
#15
Dafne Dain Gandelman Horovitz, Angelina X Acosta, Roberto Giugliani, Anna Hlavatá, Katarína Hlavatá, Michel C Tchan, Anneliese Lopes Barth, Laercio Cardoso, Emília Katiane Embiruçu de Araújo Leão, Ana Carolina Esposito, Sandra Obikawa Kyosen, Carolina Fischinger Moura De Souza, Ana Maria Martins
BACKGROUND: Enzyme replacement therapy (ERT) with laronidase (recombinant human α-L-iduronidase, Aldurazyme®) is indicated for non-neurological signs and symptoms of mucopolysaccharidosis type I (MPS I). The approved laronidase dose regimen is weekly infusions of 0.58mg/kg, however, patients and caregivers may have difficulty complying with the weekly regimen. We examined clinical outcomes, tolerability, compliance, and satisfaction in a series of patients who switched to every other week infusions...
2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/26921616/tractography-patterns-of-subthalamic-nucleus-deep-brain-stimulation
#16
Nora Vanegas-Arroyave, Peter M Lauro, Ling Huang, Mark Hallett, Silvina G Horovitz, Kareem A Zaghloul, Codrin Lungu
Deep brain stimulation therapy is an effective symptomatic treatment for Parkinson's disease, yet the precise mechanisms responsible for its therapeutic effects remain unclear. Although the targets of deep brain stimulation are grey matter structures, axonal modulation is known to play an important role in deep brain stimulation's therapeutic mechanism. Several white matter structures in proximity to the subthalamic nucleus have been implicated in the clinical benefits of deep brain stimulation for Parkinson's disease...
April 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/26900981/carbamazepine-degradation-using-a-n-doped-tio2-coated-photocatalytic-membrane-reactor-influence-of-physical-parameters
#17
Inna Horovitz, Dror Avisar, Mark A Baker, Rossana Grilli, Luca Lozzi, Daniela Di Camillo, Hadas Mamane
Commercial α-Al2O3 photocatalytic membranes with a pore size of 200 and 800-nm were coated with N-doped TiO2 photocatalytic film using a sol-gel technique for concurrent bottom-up filtration and photocatalytic oxidation. X-ray diffraction confirmed that the deposited N-doped TiO2 films are in the form of anatase with 78-84% coverage of the membrane surface. The concentration of N found by X-ray photoelectron spectroscopy was in the range of 0.3-0.9 atomic percentage. Membrane permeability after coating decreased by 50% and 12% for the 200- and 800-nm membrane substrates, respectively...
June 5, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/26820244/possible-association-between-zika-virus-infection-and-microcephaly-brazil-2015
#18
Lavinia Schuler-Faccini, Erlane M Ribeiro, Ian M L Feitosa, Dafne D G Horovitz, Denise P Cavalcanti, André Pessoa, Maria Juliana R Doriqui, Joao Ivanildo Neri, Joao Monteiro de Pina Neto, Hector Y C Wanderley, Mirlene Cernach, Antonette S El-Husny, Marcos V S Pone, Cassio L C Serao, Maria Teresa V Sanseverino
In early 2015, an outbreak of Zika virus, a flavivirus transmitted by Aedes mosquitoes, was identified in northeast Brazil, an area where dengue virus was also circulating. By September, reports of an increase in the number of infants born with microcephaly in Zika virus-affected areas began to emerge, and Zika virus RNA was identified in the amniotic fluid of two women whose fetuses had been found to have microcephaly by prenatal ultrasound. The Brazil Ministry of Health (MoH) established a task force to investigate the possible association of microcephaly with Zika virus infection during pregnancy and a registry for incident microcephaly cases (head circumference ≥2 standard deviations [SD] below the mean for sex and gestational age at birth) and pregnancy outcomes among women suspected to have had Zika virus infection during pregnancy...
January 29, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/26817655/a-comparison-of-thi-indices-leads-to-a-sensible-heat-based-heat-stress-index-for-shaded-cattle-that-aligns-temperature-and-humidity-stress
#19
A Berman, Talia Horovitz, M Kaim, H Gacitua
The combined temperature-humidity heat stress is estimated in farm animals by indices derived of an index based on human thermal comfort sensation. The latter index consists of temperature and humidity measures that sum to form the temperature-humidity index (THI). The hitherto unknown relative contribution of temperature and humidity to the THI was examined. A temperature-humidity data set (temperature 20-42 °C and relative humidity 10-70 %) was used to assess by regression procedures the relative weights of temperature and humidity in the variance of THI values produced by six commonly used heat stress indices...
October 2016: International Journal of Biometeorology
https://www.readbyqxmd.com/read/26802169/global-molecular-analysis-and-apoe-mutations-in-a-cohort-of-autosomal-dominant-hypercholesterolemia-patients-in-france
#20
René Wintjens, Dominique Bozon, Khaldia Belabbas, Félicien MBou, Jean-Philippe Girardet, Patrick Tounian, Mathilde Jolly, Franck Boccara, Ariel Cohen, Alexandra Karsenty, Béatrice Dubern, Jean-Claude Carel, Ahlam Azar-Kolakez, François Feillet, François Labarthe, Anne-Marie Colin Gorsky, Alice Horovitz, Catherine Tamarindi, Pierre Kieffer, Anne Lienhardt, Olivier Lascols, Mathilde Di Filippo, Fabienne Dufernez
Autosomal dominant hypercholesterolemia (ADH) is a human disorder characterized phenotypically by isolated high-cholesterol levels. Mutations in the low density lipoprotein receptor (LDLR), APOB, and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes are well known to be associated with the disease. To characterize the genetic background associated with ADH in France, the three ADH-associated genes were sequenced in a cohort of 120 children and 109 adult patients. Fifty-one percent of the cohort had a possible deleterious variant in LDLR, 3...
March 2016: Journal of Lipid Research
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