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JOURNAL ARTICLE
Edinsson Muñoz-Vega, Marcel Horovitz, Lisa Dönges, Thomas Schiedek, Stephan Schulz, Christoph Schüth
Sorption of hydrophobic organic contaminants onto thermally altered carbonaceous materials (TACM) constitutes a widely used technology for remediation of polluted waters. This process is typically described by sorption isotherms, with one of the most used models, the Polanyi-Dubinin-Manes (PDM) equation, including water solubility (Sw ) as a normalizing factor. In case of pharmaceutical active compounds (PhACs), Sw depends on the pH of the environment due to the ionic/ionizable behavior of these chemicals, a fact frequently ignored in sorption studies of PhACs...
April 16, 2024: Journal of Hazardous Materials
#2
JOURNAL ARTICLE
Paul W Braunstein, David J Horovitz, Andreina M Hampton, Fiona Hollis, Lori A Newman, Reilly T Enos, Joseph A McQuail
Defective brain glucose utilization is a hallmark of Alzheimer's disease (AD) while Type II diabetes and elevated blood glucose escalate the risk for AD in later life. Isolating contributions of normal aging from coincident metabolic or brain diseases could lead to refined approaches to manage specific health risks and optimize treatments targeted to susceptible older individuals. We evaluated metabolic, neuroendocrine, and neurobiological differences between young adult (6 months) and aged (24 months) male rats...
2024: Aging brain
#3
JOURNAL ARTICLE
Noam Karsh, Eden Soker-Mijalevich, Omer Horovitz
Response inhibition refers to suppressing a prepotent motor response and is often studied and discussed as an act of cognitive control. Much less attention was given to the potential contribution of motor control processes to response inhibition. Accumulated empirical findings show that a perceptual effect temporally contiguous with a response improves motor control performance. In the current study, we followed this work by manipulating action-effect temporal contiguity to enhance motor performance and investigated its impact on response selection and inhibition...
March 7, 2024: Psychological Research
#4
JOURNAL ARTICLE
Brian Walitt, Komudi Singh, Samuel R LaMunion, Mark Hallett, Steve Jacobson, Kong Chen, Yoshimi Enose-Akahata, Richard Apps, Jennifer J Barb, Patrick Bedard, Robert J Brychta, Ashura Williams Buckley, Peter D Burbelo, Brice Calco, Brianna Cathay, Li Chen, Snigdha Chigurupati, Jinguo Chen, Foo Cheung, Lisa M K Chin, Benjamin W Coleman, Amber B Courville, Madeleine S Deming, Bart Drinkard, Li Rebekah Feng, Luigi Ferrucci, Scott A Gabel, Angelique Gavin, David S Goldstein, Shahin Hassanzadeh, Sean C Horan, Silvina G Horovitz, Kory R Johnson, Anita Jones Govan, Kristine M Knutson, Joy D Kreskow, Mark Levin, Jonathan J Lyons, Nicholas Madian, Nasir Malik, Andrew L Mammen, John A McCulloch, Patrick M McGurrin, Joshua D Milner, Ruin Moaddel, Geoffrey A Mueller, Amrita Mukherjee, Sandra Muñoz-Braceras, Gina Norato, Katherine Pak, Iago Pinal-Fernandez, Traian Popa, Lauren B Reoma, Michael N Sack, Farinaz Safavi, Leorey N Saligan, Brian A Sellers, Stephen Sinclair, Bryan Smith, Joseph Snow, Stacey Solin, Barbara J Stussman, Giorgio Trinchieri, Sara A Turner, C Stephenie Vetter, Felipe Vial, Carlotta Vizioli, Ashley Williams, Shanna B Yang, Avindra Nath
Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used rigorous criteria to recruit PI-ME/CFS participants with matched controls to conduct deep phenotyping. Among the many physical and cognitive complaints, one defining feature of PI-ME/CFS was an alteration of effort preference, rather than physical or central fatigue, due to dysfunction of integrative brain regions potentially associated with central catechol pathway dysregulation, with consequences on autonomic functioning and physical conditioning...
February 21, 2024: Nature Communications
#5
JOURNAL ARTICLE
Omer Horovitz
The study investigates the behavioral manifestations of the "Theory of Food" (ToF), a novel theoretical framework centered on the early development of food perceptions. The ToF posits that childhood experiences with food shape cognitive networks influencing adult dietary choices. Stemming from the "Theory of Mind," the ToF hypothesizes that individuals construct an associative world of food images and representations mirroring the socio-cognitive world shaped by proper theory of mind development. The study, involving 249 healthy adults, employs the Cognitive Food Preference Questionnaire (CFPQ) and the Adult Food Preference Profile (AFPP) to explore the correlation between childhood and adult food preferences across diet groups (omnivores, vegetarians, and vegans)...
January 31, 2024: Nutrients
#6
JOURNAL ARTICLE
Raja Idris, Ann-Sophie Zielbauer, Julia Koepsell, Jan Kloka, Nils Wetzstein
INTRODUCTION: Tuberculosis (TB) is still a major contributor to the global health burden. Pulmonary TB can lead to life-threatening respiratory failure necessitating extracorporeal membrane oxygenation (ECMO) therapy. However, data on ECMO experience in the management of TB patients are scarce. METHODS: We conducted a systematic review of the literature using the search terms ECMO, extracorporeal membrane oxygenation, TB and tuberculosis in three databases (Medline, Web of Science and EMBASE)...
January 22, 2024: BMC Pulmonary Medicine
#7
JOURNAL ARTICLE
Moritz L Schmidbauer, Tim L T Wiegand, Linus Keidel, Julia Zibold, Konstantinos Dimitriadis
BACKGROUND: Patients with subarachnoid hemorrhage (SAH) often necessitate intra-hospital transport (IHT) during intensive care treatment. These transfers to facilities outside of the neurointensive care unit (NICU) pose challenges due to the inherent instability of the hemodynamic, respiratory, and neurological parameters that are typical in these patients. METHODS: In this retrospective, single-center cohort study, a total of 108 IHTs were analyzed for demographics, transport rationale, clinical outcomes, and pre/post-IHT monitoring parameters...
December 13, 2023: Journal of Clinical Medicine
#8
REVIEW
Mousam Roy, Amnon Horovitz
Characterization of transition and intermediate states of reactions provides insights into their mechanisms and is often achieved through analysis of linear free energy relationships. Such an approach has been used extensively in protein folding studies but less so for analyzing allosteric transitions. Here, we point out analogies in ways to characterize pathways and intermediates in folding and allosteric transitions. Achieving an understanding of the mechanisms by which proteins undergo allosteric switching is important in many cases for obtaining insights into how they function...
November 1, 2023: Current Opinion in Structural Biology
#9
JOURNAL ARTICLE
Sasa Rajsic, Robert Breitkopf, Dejan Kojic, Zoran Bukumiric, Benedikt Treml
Extracorporeal membrane oxygenation (ECMO) may improve survival in patients with severe acute respiratory distress syndrome (ARDS). However, presence of immunosuppression is a relative contraindication for ECMO, which is withheld in HIV patients. We performed a systematic review to investigate the outcome of newly diagnosed HIV patients with ARDS receiving ECMO support. Our search yielded 288 publications, with 22 studies finally included. Initial presentation included fever, respiratory distress, and cough...
December 1, 2023: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
#10
Mousam Roy, Rachel C Fleisher, Alexander I Alexandrov, Amnon Horovitz
No abstract text is available yet for this article.
September 20, 2023: Communications Biology
#11
REVIEW
Omer Horovitz, Marios Argyrides
Orthorexia nervosa is an emerging and controversial eating disorder characterized by an obsessive preoccupation with healthy eating and an extreme fixation on food purity. Despite growing public interest in orthorexia, its classification as a distinct eating disorder remains a subject of ongoing debate in the mental health community. This paper comprehensively reviews the current literature on orthorexia nervosa, exploring the prevalence rates, risk factors, diagnosis, and treatment options. The paper offers an overview of orthorexia and its historical context and explores the challenges and considerations in diagnosing orthorexia and orthorexia nervosa...
September 3, 2023: Nutrients
#12
JOURNAL ARTICLE
Mousam Roy, Rachel C Fleisher, Alexander I Alexandrov, Amnon Horovitz
The CCT/TRiC chaperonin is found in the cytosol of all eukaryotic cells and assists protein folding in an ATP-dependent manner. The heterozygous double mutation T400P and R516H in subunit CCT2 is known to cause Leber congenital amaurosis (LCA), a hereditary congenital retinopathy. This double mutation also renders the function of subunit CCT2, when it is outside of the CCT/TRiC complex, to be defective in promoting autophagy. Here, we show using steady-state and transient kinetic analysis that the corresponding double mutation in subunit CCT2 from Saccharomyces cerevisiae reduces the off-rate of ADP during ATP hydrolysis by CCT/TRiC...
August 29, 2023: Communications Biology
#13
Olivia A Zin, Luiza M Neves, Daniela P Cunha, Fabiana L Motta, Bruna N S Agonigi, Dafne D G Horovitz, Daltro C Almeida, Jocieli Malacarne, Ana Paula S Rodrigues, Adriana B Carvalho, Cinthia A Rivello, Rita Espariz, Andrea A Zin, Juliana M F Sallum, Zilton F M Vasconcelos
Hereditary hyperferritinemia-cataract syndrome (HHCS) is a rare, frequently misdiagnosed, autosomal dominant disease caused by mutations in the FTL gene. It causes bilateral pediatric cataract and hyperferritinemia without iron overload. The objective of this case series, describing three Brazilian families, is to increase awareness of HHCS, as well as to discuss possible phenotypic interactions with concurrent mutations in HFE , the gene associated with autosomal recessive inheritance hereditary hemochromatosis...
July 25, 2023: International Journal of Molecular Sciences
#14
JOURNAL ARTICLE
Demian G Liebermann, Jakub Jungwirth, Inbal Riven, Yoav Barak, Dorit Levy, Amnon Horovitz, Gilad Haran
The chaperonin GroEL is a multisubunit molecular machine that assists in protein folding in the Escherichia coli cytosol. Past studies have shown that GroEL undergoes large allosteric conformational changes during its reaction cycle. Here, we report single-molecule Förster resonance energy transfer measurements that directly probe the conformational transitions of one subunit within GroEL and its single-ring variant under equilibrium conditions. We find that four microstates span the conformational manifold of the protein and interconvert on the submillisecond time scale...
July 13, 2023: Journal of Physical Chemistry Letters
#15
JOURNAL ARTICLE
Dafne Dain Gandelman Horovitz, Maria Angelica de Faria Domingues de Lima, Lais de Carvalho Pires, Abelardo de Queiroz Campos Araujo, Fernando Regla Vargas
IRF2BPL gene variants have recently been associated to developmental disability and epilepsy in children and movement disorders in adults. So far, only few cases have been reported; here we present four novel cases identified by exome sequencing, while investigating developmental delay, adult-onset cerebellar ataxia or regression.
2023: Journal of Central Nervous System Disease
#16
JOURNAL ARTICLE
E Fleischer, L Landaeta-Díaz, G González-Medina, O Horovitz
BACKGROUND: The COVID-19 pandemic has significantly impacted daily life. Beyond severe health and economic consequences, psychological consequences have surfaced that require in-depth research to understand the pandemic's effects on mental health. Aims: This study aimed to evaluate the association between anxiety levels and anhedonia with food consumption patterns and changes in body weight over the two years since the COVID-19 outbreak in Israel. METHODS: This cross-sectional study utilized non-randomized sampling through an online survey that included 741 study participants aged 18 to 94...
June 2023: Heliyon
#17
JOURNAL ARTICLE
Joseph Mehrabi, Waseem Shehadeh, Elisa S Gallo, Ofir Artzi, Tamir Horovitz
BACKGROUND: Hyaluronic acid (HA)-based fillers are effective at mitigating acne scars due to their filling effect. Complexes of high and low molecular weight HA demonstrated a delayed biostimulatory effect. OBJECTIVE: The authors sought to compare the results of acne scar treatment using a filler composed of complexes of high and low molecular weight HA versus a traditional cross-linking HA filler. METHODS: Thirty patients with moderate-to-severe atrophic acne scarring were included in this prospective, split-face, double-blinded, randomized controlled study...
April 12, 2023: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
#18
JOURNAL ARTICLE
Laurentius Huber, Panagiotis Kassavetis, Omer Faruk Gulban, Mark Hallett, Silvina G Horovitz
Focal Hand Dystonia (FHD) is a disabling movement disorder characterized by involuntary movements, cramps and spasms. It is associated with pathological neural microcircuits in the cortical somatosensory system. While invasive preclinical modalities allow researchers to probe specific neural microcircuits of cortical layers and columns, conventional functional magnetic resonance imaging (fMRI) cannot resolve such small neural computational units. In this study, we take advantage of recent developments in ultra-high-field MRI hardware and MR-sequences to capture altered digit representations and laminar processing in FHD patients...
2023: Dystonia
#19
EDITORIAL
Amnon Horovitz, Abdussalam Azem
No abstract text is available yet for this article.
2023: Frontiers in Molecular Biosciences
#20
JOURNAL ARTICLE
Leah Tsur Shenhav, Waseem Shehade, Gerardo Muravnik, Tamir Horovitz, Ofir Artzi
BACKGROUND: Many modalities are used for periorbital rejuvenation, with a wide range of efficacy and safety. To achieve favorable outcomes with minimal downtime and adverse effects, professionals developed a hybrid laser, which allows simultaneous treatment with 2 wavelengths: fractional ablative and fractional nonablative lasers. OBJECTIVE: To evaluate the safety and efficacy of a new hybrid laser for periorbital rejuvenation. MATERIALS AND METHODS: This retrospective single-center study includes 24 patients who underwent a single-pass treatment with a CO 2 and 1570-nm hybrid laser for periorbital rejuvenation between 2020 and 2022...
May 1, 2023: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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