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https://www.readbyqxmd.com/read/29452295/what-types-of-treatment-are-provided-for-patients-with-carpal-tunnel-syndrome-a-retrospective-analysis-of-commercial-insurance
#1
Nancy A Baker, Joel Stevans, Lauren Terhorst, Allen M Haas, Yong-Fan Kuo, Soham Al Snih
BACKGROUND: Treatment of carpal tunnel syndrome (CTS) in commercially insured patients across the spectrum of provider types has rarely been described. OBJECTIVE: The purpose of this study was to describe patterns of types of treatment for patients with CTS using a large commercial insurance database. DESIGN: Retrospective cohort descriptive study SETTING: Administrative health data from the Clinformatics® Datamart (OptumInsight, Eden Prairie, MN)...
February 13, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29444946/karyopherin-alpha6-is-required-for-the-replication-of-porcine-reproductive-and-respiratory-syndrome-virus-and-zika-virus
#2
Liping Yang, Rong Wang, Shixing Yang, Zexu Ma, Shaoli Lin, Yuchen Nan, Qisheng Li, Qiyi Tang, Yan-Jin Zhang
Movement of macromolecules between the cytoplasm and the nucleus occurs through the nuclear pore complex (NPC). Karyopherins comprise a family of soluble transport factors facilitating nucleocytoplasmic translocation of proteins through the NPC. In this study, we discovered that karyopherin alpha6 (KPNA6, also known as importin alpha7) was required for the optimal replication of porcine reproductive and respiratory syndrome virus (PRRSV) and Zika virus (ZIKV), which are positive-sense, single-stranded RNA viruses replicating in the cytoplasm...
February 14, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29428899/efficacy-of-lacosamide-in-children-and-adolescents-with-drug-resistant-epilepsy-and-refractory-status-epilepticus-a-systematic-review
#3
REVIEW
Johann Sebastián Ortiz de la Rosa, Lady Diana Ladino, Paula Juliana Rodríguez, María Camila Rueda, Juan Pablo Polanía, Angie Catalina Castañeda
PURPOSE: Lacosamide, is one of the newer antiepileptic drug approved for focal drug-resistant epilepsy as an add-on treatment in patients older than 16 years. However, there is growing evidence of its use, safety and efficacy in children. We aim to evaluate efficacy and tolerability of lacosamide in focal and generalized drug-resistant epilepsy and refractory status epilepticus in the pediatric population. METHODS: We conducted a systematic review on MEDLINE, EMBASE, COCHRANE, Google Scholar and Scielo from January 2008 to January 2017...
February 7, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29419523/association-between-the-mode-of-transport-and-in-hospital-medical-complications-in-trauma-patients-findings-from-a-level-i-trauma-center-in-saudi-arabia
#4
Nawfal Aljerian, Saleh Alhaidar, Ali Alothman, Wijdan AlJohi, Faisal Abdullah Albaqami, Suliman Abdullah Alghnam
BACKGROUND: In Saudi Arabia, injury is the leading cause of death. Even if nonfatal, the impact of injuries on population health is enormous, as thousands of young patients suffer permanent disabilities every year. Unlike in developed countries, private transportation (PT) is a common means to transport trauma patients. Outcome differences between patients transported via PT relative to emergency medical services (EMS) has not been previously explored. OBJECTIVES: To evaluate the association between transportation mode and in-hospital complications among trauma patients...
January 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29410740/crude-and-adjusted-prevalence-of-sleep-complaints-in-mexico-city
#5
Alejandro Jiménez-Genchi, Jorge Caraveo-Anduaga
OBJECTIVE: To estimate the crude prevalence rates of several sleep complaints and the prevalence for each one adjusted for the coexistence of symptoms in other sleep domains in a representative sample of adult individuals from Mexico City. METHODS: A probabilistic sample of 1933 adult individuals living in Mexico City was surveyed using fourteen questions of the Sleep Disorders Questionnaire to assess sleep-related symptoms and sleep complaints. Estimates of crude prevalence rates for each sleep disturbance and adjusted for a score ≥ the 80th...
July 2017: Sleep Science
https://www.readbyqxmd.com/read/29409846/metabolic-syndrome-and-cardiovascular-risk-factors-after-hematopoietic-cell-transplantation-in-severe-mucopolysaccharidosis-type-i-hurler-syndrome
#6
Elizabeth Braunlin, Julia Steinberger, Todd DeFor, Paul Orchard, Aaron S Kelly
BACKGROUND: Hematopoietic cell transplantation is a life-saving procedure, but one associated with increasing long term cardiovascular risk requiring frequent long term follow-up. This therapy has significantly lengthened survival in mucopolysaccharidosis, type I H (Hurler syndrome), a disease with known coronary artery involvement. Metabolic syndrome - a constellation of central obesity, high blood pressure, low HDL cholesterol, elevated triglycerides and fasting blood glucose - is associated with increased cardiovascular risk, and occurs when any 3 or more of these 5 components is present within a single individual...
January 31, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29385997/proteinuric-kidney-disease-in-children-at-queen-elizabeth-central-hospital-malawi
#7
Zondiwe Victor Mwanza, Mignon McCulloch, Mark Drayson, Timothy Plant, David V Milford, Gavin Dreyer
BACKGROUND: There is a paucity of data on paediatric kidney disease in developing countries such as Malawi. Descriptive research on kidney disease is essential to improving patient outcomes. METHODS: We conducted a cross-sectional study at a tertiary hospital in Malawi from 2012 to 2013. Children under 14 years with proteinuric kidney disease were enrolled from paediatric wards and outpatient clinics at Queen Elizabeth Central Hospital (QECH). Demographic, clinical and laboratory data were collected from patients at enrolment and at 3 months review at which point clinical status and disease outcome were ascertained...
January 31, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29383261/case-report-of-a-patient-with-one-and-a-half-plus-syndrome-nine-syndrome
#8
Muhammad Uthman, Mehreen Kamran
This case talks about 'One-and-a-half plus syndrome', a clinical syndrome affecting binocular vision and facial nerve. One-and-a-half plus syndrome is a less known clinical syndrome which constitutes of a conjugate horizontal gaze palsy in one direction and an internuclear ophthalmoplegia in the other direction. Despite the known association between ischemia, autoimmune disorders, multiple sclerosis, with mono neuritis multiplex resulting in extra ocular movement disorder, one-and-a-half plus syndrome is rarely considered in the differential diagnosis of eye ball movement disorders, as many clinicians are not able to diagnose such a case as ' the eyes don't see what the mind doesn't know'...
January 2018: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29380718/antidepressant-switching-patterns-in-the-elderly
#9
Svetla Gadzhanova, Elizabeth E Roughead, Lisa G Pont
BACKGROUND: Switching between antidepressants is complex due to potential adverse outcomes such as serotonin syndrome and antidepressant discontinuation syndrome, yet switching is often required due to non-response to initial treatment. This study aimed to examine the patterns and extent of antidepressant switching in a cohort of older adults in long-term residential care. METHODS: A cohort study of medication supply data from 6011 aged care residents in 60 long-term care facilities was conducted...
January 30, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29374635/rare-occurrence-of-eight-and-a-half-syndrome-as-a-clinically-isolated-syndrome
#10
Sneha Jacob, Ann Murray
Eight-and-a-half syndrome is a rare condition that is described as a combination of one-and-a-half syndrome and an ipsilateral facial nucleus lesion. We present a clinical case of occurrence of eight-and-a-half syndrome that was caused by a demyelinating lesion in the dorsal pontine tegmentum. A 44-year-old man presented to the hospital with a subacute onset of horizontal diplopia and left-sided facial weakness. MRI revealed a T2 hyperintense lesion in his dorsal pons, which was consistent with a demyelinating pathology...
January 26, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29372449/unsafe-drug-use-and-arrhythmic-events-in-brugada-patients-with-icd-results-of-a-long-term-follow-up
#11
Diogo de Almeida Fernandes, Natália António, Marta Madeira, Pedro Sousa, Miguel Ventura, João Cristóvão, José Nascimento, Luís Elvas, Lino Gonçalves, Guilherme Mariano Pego
PURPOSE: Brugada syndrome is a hereditary disease linked with an increased risk of sudden death that may require an implantable cardioverter-defibrillator (ICD) in order to halt the arrhythmic events. The aim of this study was to identify possible triggers for appropriate ICD therapies in patients with Brugada syndrome, focusing on their past and current therapeutic profiles. METHODS: Thirty patients with high-risk Brugada syndrome, with ICD implanted at the Coimbra Hospital and University Center, were enrolled...
January 25, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29371146/couplepause-a-new-paradigm-in-treating-sexual-dysfunction-during-menopause-and-andropause
#12
REVIEW
Emmanuele A Jannini, Rossella E Nappi
BACKGROUND: At midlife and beyond, both men and women face organic changes that can affect sexual functioning. For women, ovarian exhaustion causes estrogen deficiency, leading to genitourinary syndrome of menopause, which may include vaginal dryness, irritation/itching, inadequate lubrication, and dyspareunia. Hypoactive sexual desire disorder also can result from biopsychosocial factors. For men, erectile dysfunction prevalence increases with age, and some men develop testosterone deficiency...
January 19, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29357955/demographics-of-a-large-paediatric-postural-orthostatic-tachycardia-syndrome-program
#13
Jeffrey R Boris, Thomas Bernadzikowski
OBJECTIVE: The aim of this study was to identify and evaluate demographic and clinical features of paediatric patients with postural orthostatic tachycardia syndrome in a tertiary hospital speciality clinic. METHOD: This is a retrospective review of clinical data obtained during initial outpatient evaluation. RESULTS: A total of 708 patients met the evaluation criteria. Female patients outnumbered males, 3.45:1. Caucasians were over-represented at 94...
January 23, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29352691/adopting-an-early-invasive-strategy-for-non-st-elevation-myocardial-infarction-analysis-of-the-portuguese-registry-on-acute-coronary-syndromes
#14
Gonçalo Morgado, Hélder Pereira, Daniel Caldeira
INTRODUCTION: In patients with non-ST-elevation myocardial infarction (NSTEMI), the best timing for coronary angiography is not definitely established, although it is recognized that in high-risk patients it should be performed within the first 24 hours. The aim of this work was to describe the evolution over time of the use of an invasive strategy in the treatment of NSTEMI and in-hospital mortality. METHODS: We performed a retrospective analysis of patients admitted with NSTEMI included in the Portuguese Registry on Acute Coronary Syndromes (ProACS) between 2002 and 2015...
January 15, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29351181/cleft-palate-repair-description-of-an-approach-its-evolution-and-analysis-of-post-operative-fistulas
#15
Raymond W Tse, Babette Siebold
BACKGROUND: Fistulas following cleft palate repair impair speech, health, and hygiene and occur in up to 35% cases. The purpose of this study was to (1) describe the evolution of a surgical approach to cleft palate repair; (2) assess the rates, causes, and predictive factors of fistulas; (3) assess the temporal association of modifications to fistula rates during six years of a single surgeon experience. METHODS: Consecutive patients (N=146) undergoing cleft palate repair were included...
January 12, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29332008/leg-stereotypy-syndrome-phenomenology-and-prevalence
#16
Mitesh Lotia, Michele K York, Adriana M Strutt, Joseph Jankovic
OBJECTIVES: To describe the phenomenology and prevalence of leg stereotypy syndrome (LSS), characterised chiefly by repetitive, rhythmical, stereotypic leg movement, especially when sitting. METHODS: We sought to characterise LSS in two groups of subjects: (1) general population (GP) group, defined as individuals accompanying patients during their visits to Baylor College of Medicine Parkinson's Disease Center and Movement Disorders Clinic who are not genetically related to the patients; and (2) movement disorders (MD) group, composed of consecutive patients with diagnoses of restless legs syndrome, Parkinson's disease, Tourette syndrome and tardive dyskinesia...
January 13, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29320517/explaining-the-decline-in-coronary-heart-disease-mortality-rates-in-the-slovak-republic-between-1993-2008
#17
Marek Psota, Piotr Bandosz, Eva Gonçalvesová, Mária Avdičová, Mária Bucek Pšenková, Martin Studenčan, Jarmila Pekarčíková, Simon Capewell, Martin O'Flaherty
OBJECTIVE: Between the years 1993 and 2008, mortality rates from coronary heart disease (CHD) in the Slovak Republic have decreased by almost one quarter. However, this was a smaller decline than in neighbouring countries. The aim of this modelling study was therefore to quantify the contributions of risk factor changes and the use of evidence-based medical therapies to the CHD mortality decline between 1993 and 2008. METHODS: We identified, obtained and scrutinised the data required for the model...
2018: PloS One
https://www.readbyqxmd.com/read/29316724/biochemical-and-clinical-impact-of-organic-uremic-retention-solutes-a-comprehensive-update
#18
REVIEW
Raymond Vanholder, Anneleen Pletinck, Eva Schepers, Griet Glorieux
In this narrative review, the biological/biochemical impact (toxicity) of a large array of known individual uremic retention solutes and groups of solutes is summarized. We classified these compounds along their physico-chemical characteristics as small water-soluble compounds or groups, protein bound compounds and middle molecules. All but one solute (glomerulopressin) affected at least one mechanism with the potential to contribute to the uremic syndrome. In general, several mechanisms were influenced for each individual solute or group of solutes, with some impacting up to 7 different biological systems of the 11 considered...
January 8, 2018: Toxins
https://www.readbyqxmd.com/read/29312874/one-and-a-half-syndrome-with-its-spectrum-disorders
#19
Fang Xue, Lihong Zhang, Li Zhang, Zhenguang Ying, Ou Sha, Yan Ding
One-and-a-half syndrome is a syndrome characterized by horizontal movement disorders of the eyeballs, which was first reported and named by Fisher in 1967. It presents a combination of ipsilateral conjugate horizontal gaze palsy (one) and ipsilateral internuclear ophthalmoplegia (INO) (a half). On the basis of the one-and-a-half syndrome, there are a series of related rare syndromes called the one-and-a-half syndrome spectrum disorders. This article reviews rare cases of one-and-a-half syndrome spectrum disorder, describes the clinical and pathological features of different syndromes, and summarizes their nomenclature...
December 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29311367/one-and-a-half-syndrome-secondary-to-transorbital-penetrating-injury
#20
Tess Fitzpatrick, Margaret Moores, Simon Thebault, Hyman Rabinovitch
No abstract text is available yet for this article.
January 9, 2018: Neurology
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