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MiR-24 ovarian cancer

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https://www.readbyqxmd.com/read/26296081/enrichment-analysis-identifies-functional-microrna-disease-associations-in-humans
#1
Dandan Yuan, Xiaomeng Cui, Yang Wang, Yilei Zhao, Huiying Li, Suangjiu Hu, Xiaodan Chu, Yan Li, Qiang Li, Qian Liu, Wenliang Zhu
Substantial evidence has shown that microRNAs (miRNAs) may be causally linked to the occurrence and progression of human diseases. Herein, we conducted an enrichment analysis to identify potential functional miRNA-disease associations (MDAs) in humans by integrating currently known biological data: miRNA-target interactions (MTIs), protein-protein interactions, and gene-disease associations. Two contributing factors to functional miRNA-disease associations were quantitatively considered: the direct effects of miRNA that target disease-related genes, and indirect effects triggered by protein-protein interactions...
2015: PloS One
https://www.readbyqxmd.com/read/24911418/circulating-microrna-expression-profiles-in-ovarian-cancer
#2
L Ayaz, F Çayan, Ş Balci, A Görür, S Akbayir, H Yıldırım Yaroğlu, N Doğruer Unal, L Tamer
MicroRNA (miRNA) is an abundant class of small non-coding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression of human cancer. However, information about ovarian cancer-related miRNA is mostly limited to tissue miRNA. The aim of this study was to find specific profiles of plasma-derived miRNAs of ovarian cancer. In this present study, the expression profiles of 740 miRNAs in plasma from 18 patients and 24 healthy women subjects were evaluated using microfluidic based multiplex qRT-PCR...
October 2014: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/24411027/micrornas-regulate-several-functions-of-normal-tissues-and-malignancies
#3
REVIEW
Kuo-Chang Wen, Pi-Ling Sung, Ming-Shyen Yen, Chi-Mu Chuang, Wen-Shiung Liou, Peng-Hui Wang
MicroRNAs (miRNAs, miRs) are a cluster of naturally occurring small non-coding RNA molecules of 19-24 nucleotides in length. miRs control gene expression post-transcriptionally by binding to a specific site at the 3'-UTR of target mRNA, which results in mRNA cleavage and translation repression. Nearly 1000 miRs in the human genome have been identified, and it is believed that these miRs contribute to at least 60% of the human transcriptome. Recent research has shown that miRs are emerging as important regulators of cellular differentiation and dedifferentiation...
December 2013: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/24393345/ovarian-cancer-cell-invasiveness-is-associated-with-discordant-exosomal-sequestration-of-let-7-mirna-and-mir-200
#4
Miharu Kobayashi, Carlos Salomon, Jorge Tapia, Sebastian E Illanes, Murray D Mitchell, Gregory E Rice
BACKGROUND: The role of exosomes in the pathogenesis and metastatic spread of cancer remains to be fully elucidated. Recent studies support the hypothesis that the release of exosomes from cells modifies local extracellular conditions to promote cell growth and neovascularisation. In addition, exosomes may modify the phenotype of parent and/or target cell. For example, sequestration of signaling mediators into exosomes may reduce their intracellular bioavailability to the parent cell thereby altering cell phenotype and metastatic potential...
2014: Journal of Translational Medicine
https://www.readbyqxmd.com/read/24016480/-effects-of-mir-135a-on-hoxa10-expression-proliferation-and-apoptosis-of-ovarian-cancer-cells
#5
Wei-wei Tang, Gui-ping Wan, Yi-cong Wan, Lin Zhang, Wen-jun Cheng
OBJECTIVE: To investigate the effects of miR-135a on HOXA10 expression, proliferation and apoptosis of SKOV3 cells. METHODS: (1) Through computer-aided algorithms,the predicted target gene of miR-135a (HOXA10)were determined. (2) miR-135a mimics, miR-135a inhibitor and negative control were transfected into SKOV3 cells, respectively.Reverse transcription (RT)-PCR, western blot analysis were used to examine the expression levels of HOXA10 at different times (24, 48 and 72 hours)...
May 2013: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/23621234/therapeutic-potential-of-an-anti-diabetic-drug-metformin-alteration-of-mirna-expression-in-prostate-cancer-cells
#6
Cigir Biray Avci, Ece Harman, Yavuz Dodurga, Sunde Yilmaz Susluer, Cumhur Gunduz
BACKGROUND AND AIMS: Prostate cancer is the most commonly diagnosed cancer in males in many populations. Metformin is the most widely used anti-diabetic drug in the world, and there is increasing evidence of a potential efficacy of this agent as an anti-cancer drug. Metformin inhibits the proliferation of a range of cancer cells including prostate, colon, breast, ovarian, and glioma lines. MicroRNAs (miRNAs) are a class of small, non- coding, single-stranded RNAs that downregulate gene expression...
2013: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/23045278/mir-141-regulates-keap1-and-modulates-cisplatin-sensitivity-in-ovarian-cancer-cells
#7
M T M van Jaarsveld, J Helleman, A W M Boersma, P F van Kuijk, W F van Ijcken, E Despierre, I Vergote, R H J Mathijssen, E M J J Berns, J Verweij, J Pothof, E A C Wiemer
Epithelial ovarian cancer is the most lethal gynecological malignancy in the Western world. A major impediment for the successful treatment is the development of drug resistance. The molecular processes that contribute to resistance have been extensively studied; however, there is not much known about regulation by microRNAs (miRNAs). We compared miRNA expression profiles of an isogenic cisplatin-sensitive and -resistant ovarian cancer cell line pair (A2780/A2780 DDP) and found 27 miRNAs to be differentially expressed (2-fold)...
September 5, 2013: Oncogene
https://www.readbyqxmd.com/read/22455133/-expression-of-mir-130a-in-cisplatin-resistant-cell-lines-of-ovarian-cancer
#8
Ling-Yun Yang, Hong-Jing Wang, Xi-Biao Jia, Xue Wang, Juan Luo, Xiao-Yan Zhang
OBJECTIVE: To determine the expression of miR-130a in cisplatin resistant cell lines of ovarian cancer and its impact on cisplatin resistance. METHODS: Cisplatin resistant ovarian cancer cell lines were established by stepwise selection with gradual increase of cisplatin. MTT assay was applied to indentify the cisplatin resistant cell lines and determine their resistance index. The expression of miR-130a was measured by SYBR green real-time PCR. RESULTS : The resistance index of A2780/CIS1, A2780/CIS2 and SKOV3/CIS was 30...
January 2012: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/21807768/an-observational-study-of-bevacizumab-induced-hypertension-as-a-clinical-biomarker-of-antitumor-activity
#9
Olivier Mir, Romain Coriat, Laure Cabanes, Stanislas Ropert, Bertrand Billemont, Jérôme Alexandre, Jean-Philippe Durand, Jean-Marc Treluyer, Bertrand Knebelmann, François Goldwasser
BACKGROUND: Hypertension is a common toxicity of bevacizumab, but the frequency of assessment of blood pressure and standardized grading remain to be defined. This study aimed to describe the incidence of bevacizumab-induced hypertension and factors associated with its development, then to retrospectively assess its relation with activity. PATIENTS AND METHODS: One hundred nineteen patients with advanced or metastatic non-small cell lung cancer, colorectal cancer, or ovarian cancer receiving bevacizumab (2...
2011: Oncologist
https://www.readbyqxmd.com/read/21042738/short-gc-rich-rna-similar-to-mir-1909-and-1915-folds-in-silico-with-the-5-utr-and-orf-of-notch-and-responders-potential-for-the-elimination-of-cancer-stem-cells
#10
Yufeng Li, Takashi Mine, Constantin G Ioannides
Novel therapeutic approaches to eliminate cancer stem cells (CSCs) are being developed. This development is imperative as CSCs are resistant to drugs; they divide activated by ligands on the epithelium or on neighboring cancer cells. Specific commands for division originate from Notch-1 ligands. Notch-1 cleavage inhibitors can have opposite effects from the ones expected when the levels of Notch ligands are high on neighboring cancer cells. High levels of Jagged-1 are a common feature of ovarian tumors. Some gene pathways enhance, others repress transcription of Notch-1, while Notch-1 itself activates Myc and HIF-1α...
December 2010: Oncology Reports
https://www.readbyqxmd.com/read/20683447/whole-blood-derived-mirna-profiles-as-potential-new-tools-for-ovarian-cancer-screening
#11
S F M Häusler, A Keller, P A Chandran, K Ziegler, K Zipp, S Heuer, M Krockenberger, J B Engel, A Hönig, M Scheffler, J Dietl, J Wischhusen
BACKGROUND: Screening is an unsolved problem for ovarian cancer (OvCA). As late detection is equivalent to poor prognosis, we analysed whether OvCA patients show diagnostically meaningful microRNA (miRNA) patterns in blood cells. METHODS: Blood-borne whole miRNome profiles from 24 patients with OvCA and 15 age- and sex-matched healthy controls were biostatistically evaluated. RESULTS: Student's t-test revealed 147 significantly deregulated miRNAs before and 4 after Benjamini-Hochberg adjustment...
August 24, 2010: British Journal of Cancer
https://www.readbyqxmd.com/read/9859063/-incidence-of-de-novo-neoplasms-after-liver-transplantation
#12
M Berenguer, M Prieto, M Bustamante, D Carrasco, R López-Andújar, J Mir, J Berenguer
BACKGROUND: De novo malignancy developing after transplantation constitutes a well-known complication or organ transplantation, mainly described among renal recipients. AIM: To determine the incidence of de novo internal malignancies (excluding therefore skin cancers and recurrent hepatocellular carcinoma) in a cohort of 183 patients undergoing liver transplantation (OLT) between 6/1/1991 and 12/1/1996 with a minimum follow-up of 12 months and under cyclosporine-azathioprine-prednisone...
October 24, 1998: Medicina Clínica
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