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https://www.readbyqxmd.com/read/29346507/activity-and-safety-of-afatinib-in-a-window-pre-operative-eortc-study-in-patients-with-squamous-cell-carcinoma-of-the-head-and-neck-scchn
#1
J P Machiels, P Bossi, J Menis, M Lia, C Fortpied, Y Liu, R Lhommel, M Lemort, S Schmitz, S Canevari, L De Cecco, M Guzzo, R Bianchi, P Quattrone, F Crippa, T Duprez, Y Lalami, M Quiriny, N de Saint Aubain, P M Clement, R Coropciuc, E Hauben, L F Licitra
Background: To investigate the activity and safety of afatinib in the pre-operative treatment of squamous cell carcinoma of the head and neck (SCCHN). Patients and methods: This study was an open-label, randomized, multicenter, phase II window of opportunity trial. Treatment-naïve SCCHN patients selected for primary curative surgery were randomized (5:1 ratio) to receive afatinib during 14 days (day -15 until day -1) before surgery (day 0) or no treatment. Tumor biopsies, 2-[fluorine-18]-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET), and magnetic resonance imaging (MRI) were performed at diagnosis and just before surgery...
January 15, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29341356/all-over-the-map-an-interobserver-agreement-study-of-tumor-location-based-on-the-pi-radsv2-sector-map
#2
Matthew D Greer, Joanna H Shih, Tristan Barrett, Sandra Bednarova, Ismail Kabakus, Yan Mee Law, Haytham Shebel, Maria J Merino, Bradford J Wood, Peter A Pinto, Peter L Choyke, Baris Turkbey
BACKGROUND: Prostate imaging reporting and data system version 2 (PI-RADSv2) recommends a sector map for reporting findings of prostate cancer mulitparametric MRI (mpMRI). Anecdotally, radiologists may demonstrate inconsistent reproducibility with this map. PURPOSE: To evaluate interobserver agreement in defining prostate tumor location on mpMRI using the PI-RADSv2 sector map. STUDY TYPE: Retrospective. POPULATION: Thirty consecutive patients who underwent mpMRI between October, 2013 and March, 2015 and who subsequently underwent prostatectomy with whole-mount processing...
January 17, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29339079/diagnostic-usefulness-of-combination-of-diffusion-weighted-imaging-and-t2wi-including-apparent-diffusion-coefficient-in-breast-lesions-assessment-of-histologic-grade
#3
Keum Won Kim, Cherie M Kuzmiak, Young Joong Kim, Jae Young Seo, Hae Kyoung Jung, Mu-Sik Lee
PURPOSE: This study aimed to compare the diagnostic values of a combination of diffusion-weighted imaging and T2-weighted imaging (DWI-T2WI) with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and to evaluate the correlation of DWI with the histologic grade in breast cancer. MATERIALS AND METHODS: This study evaluated a total of 169 breast lesions from 136 patients who underwent both DCE-MRI and DWI (b value, 1000s/mm2). Morphologic and kinetic analyses for DCE-MRI were classified according to the Breast Imaging-Reporting and Data System...
January 12, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29331677/identification-of-potential-mr-derived-biomarkers-for-tumor-tissue-response-to-177lu-octreotate-therapy-in-an-animal-model-of-small-intestine-neuroendocrine-tumor
#4
Mikael Montelius, Johan Spetz, Oscar Jalnefjord, Evelin Berger, Ola Nilsson, Maria Ljungberg, Eva Forssell-Aronsson
Magnetic resonance (MR) methods enable noninvasive, regional tumor therapy response assessment, but associations between MR parameters, underlying biology, and therapeutic effects must be investigated. The aim of this study was to investigate response assessment efficacy and biological associations of MR parameters in a neuroendocrine tumor (NET) model subjected to radionuclide treatment. Twenty-one mice with NETs received 177Lu-octreotate at day 0. MR experiments (day -1, 1, 3, 8, and 13) included T2-weighted, dynamic contrast-enhanced (DCE) and diffusion-weighted imaging (DWI) and relaxation measurements (T1/T2*)...
January 10, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29330968/correlation-of-dynamic-contrast-enhanced-mri-derived-volume-transfer-constant-with-histological-angiogenic-markers-in-high-grade-gliomas
#5
Ningning Di, Chenjun Yao, Wenna Cheng, Yan Ren, Jianxun Qu, Bin Wang, Zhenwei Yao
INTRODUCTION: To ascertain if the volume transfer constant (Ktrans ) derived from T1 dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) correlates with the immunohistological markers of angiogenesis in high-grade gliomas. METHODS: Fifty-one image-guided biopsy specimens in 34 patients with newly presenting high-grade gliomas (grade III = 16; grade IV = 18) underwent preoperative imaging (conventional imaging and T1 DCE-MRI). We correlated vascular endothelial growth factor (VEGF) expression and the microvessel density (MVD) of MRI-guided biopsy specimens with the corresponding DCE-derived Ktrans ...
January 13, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29327116/evaluation-of-hemodynamic-imaging-findings-of-hypervascular-hepatocellular-carcinoma-comparison-between-dynamic-contrast-enhanced-magnetic-resonance-imaging-using-radial-volumetric-imaging-breath-hold-examination-with-k-space-weighted-image-contrast-reconstruction
#6
Masahiro Kurozumi, Yasunari Fujinaga, Yoshihiro Kitou, Akira Yamada, Ayumi Ohya, Yasuo Adachi, Yoshinori Tsukahara, Marcel D Nickel, Katsuya Maruyama, Takeshi Uehara, Shin-Ichi Miyagawa, Masumi Kadoya
PURPOSE: To compare the visualization of hemodynamic imaging findings of hypervascular hepatocellular carcinoma (HCC) on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using radial volumetric imaging breath-hold examination with k-space-weighted image contrast reconstruction (r-VIBE-KWIC) versus dynamic computed tomography during hepatic arteriography (dyn-CTHA). MATERIALS AND METHODS: We retrospectively reviewed the databases of preoperative DCE-MRI using r-VIBE-KWIC, dyn-CTHA, and postoperative pathology of resected specimens...
January 11, 2018: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29325321/-preliminary-applicability-evaluation-of-prostate-imaging-reporting-and-data-system-version-2-diagnostic-score-in-3-0t-multi-parameters-magnetic-resonance-imaging-combined-with-prostate-specific-antigen-density-for-prostate-cancer
#7
M Z Zuo, W L Zhao, C G Wei, C Y Zhang, R Wen, Y F Gu, M J Li, Y Y Zhang, J F Wu, X Li, J K Shen
Objective: To investigate the preliminary applicability of Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) score in the condition of 3.0T multi-parametric magnetic resonance imaging (Mp-MRI) combined with clinical classic indicators for the diagnosis of prostate cancer (PCa). Methods: The clinical and MRI materials of 247 patients of suspicious prostate disease treated in Second Affiliated Hospital of Soochow University from June 2015 to November 2016 were analyzed retrospectively, including 110 cases with PCa and 137 cases without cancer...
December 19, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29320532/automatic-outer-and-inner-breast-tissue-segmentation-using-multi-parametric-mri-images-of-breast-tumor-patients
#8
Snekha Thakran, Subhajit Chatterjee, Meenakshi Singhal, Rakesh Kumar Gupta, Anup Singh
The objectives of the study were to develop a framework for automatic outer and inner breast tissue segmentation using multi-parametric MRI images of the breast tumor patients; and to perform breast density and tumor tissue analysis. MRI of the breast was performed on 30 patients at 3T-MRI. T1, T2 and PD-weighted(W) images, with and without fat saturation(WWFS), and dynamic-contrast-enhanced(DCE)-MRI data were acquired. The proposed automatic segmentation approach was performed in two steps. In step-1, outer segmentation of breast tissue from rest of body parts was performed on structural images (T2-W/T1-W/PD-W without fat saturation images) using automatic landmarks detection technique based on operations like profile screening, Otsu thresholding, morphological operations and empirical observation...
2018: PloS One
https://www.readbyqxmd.com/read/29317433/improved-evaluation-of-antivascular-cancer-therapy-using-constrained-tracer-kinetic-modeling-for-multi-agent-dynamic-contrast-enhanced-mri
#9
Stefanie Hectors, Igor Jacobs, Jasper Lok, Johannes Peters, Johan Bussink, Freek J M Hoeben, Henk Keizer, Henk M Janssen, Klaas Nicolay, Matthias Schabel, Gustav Strijkers
Dynamic contrast-enhanced MRI (DCE-MRI) is a promising technique for assessing the response of tumor vasculature to anti-vascular therapies. Multi-agent DCE-MRI employs a combination of low and high molecular weight contrast agents, which potentially improves the accuracy of estimation of tumor hemodynamic and vascular permeability parameters. In this study, we employed multi-agent DCE-MRI to assess changes in tumor hemodynamics and vascular permeability after vascular-disrupting therapy. Multi-agent DCE-MRI (sequential injection of G5 dendrimer, G2 dendrimer, and Gd-DOTA) was performed in tumor-bearing mice before, 2 h and 24 h after treatment with vascular disrupting agent DMXAA or placebo...
January 9, 2018: Cancer Research
https://www.readbyqxmd.com/read/29317377/multiparametric-mri-for-the-detection-of-local-recurrence-of-prostate-cancer-in-the-setting-of-biochemical-recurrence-after-low-dose-rate-brachytherapy
#10
Luca F Valle, Matthew D Greer, Joanna H Shih, Tristan Barrett, Yan Mee Law, Andrew B Rosenkrantz, Haytham Shebel, Akhil Muthigi, Daniel Su, Maria J Merino, Bradford J Wood, Peter A Pinto, Andra V Krauze, Aradhana Kaushal, Peter L Choyke, Barış Türkbey, Deborah E Citrin
PURPOSE: Prostate multiparametric magnetic resonance imaging (mpMRI) has utility in detecting post-radiotherapy local recurrence. We conducted a multireader study to evaluate the diagnostic performance of mpMRI for local recurrence after low dose rate (LDR) brachytherapy. METHODS: A total of 19 patients with biochemical recurrence after LDR brachytherapy underwent 3T endorectal coil mpMRI with T2-weighted imaging, dynamic contrast-enhanced imaging (DCE) and diffusion-weighted imaging (DWI) with pathologic confirmation...
January 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29316711/renal-cell-carcinoma-perfusion-before-and-after-radiofrequency-ablation-measured-with-dynamic-contrast-enhanced-mri-a-pilot-study
#11
Tze Min Wah, Steven Sourbron, Daniel Jonathan Wilson, Derek Magee, Walter Martin Gregory, Peter John Selby, David L Buckley
AIM: To investigate if the early treatment effects of radiofrequency ablation (RFA) on renal cell carcinoma (RCC) can be detected with dynamic contrast enhanced (DCE)-MRI and to correlate RCC perfusion with RFA treatment time. MATERIALS AND METHODS: 20 patients undergoing RFA of their 21 RCCs were evaluated with DCE-MRI before and at one month after RFA treatment. Perfusion was estimated using the maximum slope technique at two independent sittings. Total RCC blood flow was correlated with total RFA treatment time, tumour location, size and histology...
January 8, 2018: Diagnostics
https://www.readbyqxmd.com/read/29314345/differentiation-between-vasogenic-edema-and-infiltrative-tumor-in-patients-with-high-grade-gliomas-using-texture-patch-based-analysis
#12
Moran Artzi, Gilad Liberman, Deborah T Blumenthal, Orna Aizenstein, Felix Bokstein, Dafna Ben Bashat
BACKGROUND: High-grade gliomas (HGGs) induce both vasogenic edema and extensive infiltration of tumor cells, both of which present with similar appearance on conventional MRI. Using current radiological criteria, differentiation between these tumoral and nontumoral areas within the nonenhancing lesion area remains challenging. PURPOSE: To use radiomics patch-based analysis, based on conventional MRI, for the classification of the nonenhancing lesion area in patients with HGG into tumoral and nontumoral components...
January 3, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29314060/dynamic-field-of-view-imaging-to-increase-temporal-resolution-in-the-early-phase-of-contrast-media-uptake-in-breast-dce-mri-a-feasibility-study
#13
Federico D Pineda, Ty O Easley, Gregory S Karczmar
PURPOSE: To increase diagnostic accuracy of breast MRI by increasing temporal resolution and more accurately sampling the early kinetics of contrast media uptake. We tested the feasibility of accelerating bilateral breast DCE-MRI by reducing the FOV, allowing aliasing, and unfolding the resulting images. METHODS: Previous experience with an 'ultrafast' protocol for bilateral breast DCE-MRI (6s-10s temporal resolution) showed that the number of significantly enhancing voxels is very low in the first 30 to 45 seconds after contrast media injection...
January 3, 2018: Medical Physics
https://www.readbyqxmd.com/read/29312587/tumour-microenvironmental-blood-flow-determines-a-metabolomic-signature-identifying-lysophospholipids-and-resolvin-d-as-biomarkers-in-endometrial-cancer-patients
#14
Núria Eritja, Mariona Jové, Kristine Eldevik Fasmer, Sònia Gatius, Manuel Portero-Otin, Jone Trovik, Camilla Krakstad, Joaquim Sol, Reinald Pamplona, Ingfrid S Haldorsen, Xavier Matias-Guiu
Purpose: We aimed to study the potential influence of tumour blood flow -obtained from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)- in the metabolomic profiles of endometrial tumours. Methods: Liquid chromatography coupled to mass spectrometry established the metabolomic profile of endometrial cancer lesions exhibiting high (n=12) or low (n=14) tumour blood flow at DCE-MRI. Univariate and multivariate statistics (ortho-PLS-DA, a random forest (RF) classifier and hierarchical clustering) and receiver operating characteristic (ROC) curves were used to establish a panel for potentially discriminating tumours with high versus low blood flow...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29300270/18f-fluorodeoxyglucose-pet-ct-and-dynamic-contrast-enhanced-mri-as-imaging-biomarkers-in-malignant-pleural-mesothelioma
#15
David O Hall, Clare E Hooper, Julie Searle, Michael Darby, Paul White, John E Harvey, Jeremy P Braybrooke, Nick A Maskell, Vidan Masani, Iain D Lyburn
PURPOSE: The purpose of this study was to compare the use of fluorine-18-fluorodeoxyglucose (F-FDG) PET with computed tomography (CT) and dynamic contrast-enhanced (DCE) MRI to predict prognosis and monitor treatment in malignant pleural mesothelioma. PATIENTS AND METHODS: F-FDG PET/CT and DCE-MRI studies carried out as part of the South West Area Mesothelioma Pemetrexed trial were used. F-FDG PET/CT and DCE-MRI studies were carried out before treatment, and after two cycles of chemotherapy, on patients treated with pemetrexed and cisplatin...
January 3, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29300175/comparison-of-arterial-input-functions-measured-from-ultra-fast-dynamic-contrast-enhanced-mri-and-dynamic-contrast-enhanced-computed-tomography-in-prostate-cancer-patients
#16
Shiyang Wang, Zheng Feng Feng Lu, Xiaobing Fan, Milica Medved, Xia Jiang, Steffen Sammet, Ambereen Yousuf, Federico Pineda, Aytekin Oto, Gregory S Karczmar
The purpose of this study was to evaluate the accuracy of arterial input functions (AIFs) measured from dynamic contrast enhanced (DCE) MRI following a low dose of contrast media injection. The AIFs measured from DCE computed tomography (CT) were used as 'gold standard'. Total twenty patients received CT and MRI scans on the same day. Patients received 120mL Iohexol in DCE-CT and a low dose of (0.015mM/kg) of gadobenate dimeglumine in DCE-MRI. The AIFs were measured in the iliac artery and normalized to the CT and MRI contrast agent doses...
January 4, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29295753/differentiation-between-malignant-and-benign-breast-masses-combination-of-semi-quantitative-analysis-on-dce-mri-and-histogram-analysis-of-adc-maps
#17
H-L Liu, M Zong, H Wei, J-J Lou, S-Q Wang, Q-G Zou, H-B Shi, Y-N Jiang
AIM: To investigate the performance of combined semi-quantitative analysis on dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) and histogram analysis of diffusion-weighted imaging (DWI) for distinguishing malignant from benign breast masses. MATERIALS AND METHODS: This study included 178 patients with breast masses (benign:malignant=88:9) who underwent both DCE-MRI and DWI. The semi-quantitative parameters, derived from DCE-MRI, included maximum slope of increase (MSI), signal intensity slope (SIslope), initial percentage of enhancement (Einitial), percentage of peak enhancement (Epeak), early signal enhancement ratio (ESER), and second enhancement percentage (SEP)...
December 30, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29279173/differentiating-between-benign-and-malignant-sinonasal-lesions-using-dynamic-contrast-enhanced-mri-and-intravoxel-incoherent-motion
#18
Jingxuan Jiang, Zebin Xiao, Zuohua Tang, Yufeng Zhong, Jinwei Qiang
PURPOSE: To explore the value of dynamic contrast-enhanced MRI (DCE-MRI) and intravoxel incoherent motion (IVIM) for distinguishing between benign and malignant sinonasal lesions and investigate the correlations between the two methods. METHODS AND MATERIALS: Patients with sinonasal lesions (42 benign and 31 malignant) who underwent DCE-MRI and IVIM before confirmation by histopathology were enrolled in this prospective study. Parameters derived from DCE-MRI and IVIM were measured, the optimal cut-off values for differential diagnosis were determined, and the correlations between the two methods were evaluated...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29279147/seminal-vesicle-invasion-on-multi-parametric-magnetic-resonance-imaging-correlation-with-histopathology
#19
Nikolaos Grivas, Karel Hinnen, Jeroen de Jong, Wilma Heemsbergen, Luc Moonen, Thelma Witteveen, Henk van der Poel, Stijn Heijmink
OBJECTIVES: The pre-treatment risk of seminal vesicle (SV) invasion (SVI) from prostate cancer is currently based on nomograms which include clinical stage (cT), Gleason score (GS) and prostate-specific antigen (PSA). The aim of our study was to evaluate the staging accuracy of 3T (3T) multi-parametric (mp) Magnetic Resonance Imaging (MRI) by comparing the imaging report of SVI with the tissue histopathology. The additional value in the existing prediction models and the role of radiologists' experience were also examined...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29278764/robust-and-efficient-pharmacokinetic-parameter-non-linear-least-squares-estimation-for-dynamic-contrast-enhanced-mri-of-the-prostate
#20
Soudabeh Kargar, Eric A Borisch, Adam T Froemming, Akira Kawashima, Lance A Mynderse, Eric G Stinson, Joshua D Trzasko, Stephen J Riederer
PURPOSE: To describe an efficient numerical optimization technique using non-linear least squares to estimate perfusion parameters for the Tofts and extended Tofts models from dynamic contrast enhanced (DCE) MRI data and apply the technique to prostate cancer. METHODS: Parameters were estimated by fitting the two Tofts-based perfusion models to the acquired data via non-linear least squares. We apply Variable Projection (VP) to convert the fitting problem from a multi-dimensional to a one-dimensional line search to improve computational efficiency and robustness...
December 23, 2017: Magnetic Resonance Imaging
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