keyword
MENU ▼
Read by QxMD icon Read
search

DCE MRI

keyword
https://www.readbyqxmd.com/read/28817662/single-scan-rest-stress-imaging-with-99mtc-sestamibi-and-cadmium-zinc-telluride-based-spect-for-hyperemic-flow-quantification-a-feasibility-study-evaluated-with-cardiac-magnetic-resonance-imaging
#1
Yu-Hua Dean Fang, Yuan-Chang Liu, Kung-Chu Ho, Feng-Cheng Kuo, Ching-Fang Yang, Tzu-Chen Yen, I-Chang Hsieh
INTRODUCTION: We aimed to evaluate whether the hyperemic myocardial blood flow (MBF) can be estimated using cadmium zinc telluride (CZT)-based single-photon emission computed tomography (SPECT) cameras with a single, rapid rest/stress dynamic scan. Dynamic contrast-enhanced (DCE) cardiac magnetic resonance imaging (MRI) was used as a reference modality for flow measurement. MATERIALS AND METHODS: The proposed protocol included both the rest and stress acquisitions within a 24-min scan...
2017: PloS One
https://www.readbyqxmd.com/read/28806317/quantitative-evaluation-of-diffusion-and-dynamic-contrast-enhanced-magnetic-resonance-imaging-for-differentiation-between-primary-central-nervous-system-lymphoma-and-glioblastoma
#2
Shanshan Lu, Siqi Wang, Qianqian Gao, Minlin Zhou, Yang Li, Peng Cao, Xunning Hong, Haibin Shi
OBJECTIVE: This study aimed to evaluate the utility of diffusion and permeability parameters derived from diffusion-weighted imaging and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for differentiating primary central nervous system lymphoma (PCNSL) and glioblastoma multiforme (GBM) and to assess the correlation among these parameters. MATERIALS AND METHODS: Forty-two patients with GBM and 18 patients with PCNSL underwent conventional 3.0-T MRI, diffusion-weighted imaging, and DCE-MRI before surgery...
August 12, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28803622/effect-of-hyoscine-butylbromide-on-prostate-multiparametric-mri-anatomical-and-functional-image-quality
#3
R A Slough, I Caglic, N L Hansen, A J Patterson, T Barrett
AIM: To evaluate the effect of the spasmolytic agent hyoscine butylbromide (HBB) on the quality of anatomical and functional imaging of the prostate. MATERIALS AND METHODS: One hundred and seventy-three patients were included in this retrospective study. Eighty-seven patients received intravenous HBB prior to scanning (HBB group) and 86 patients did not (non-HBB group). Multiparametric (mp) 3 T magnetic resonance imaging (MRI) was performed using a 32-channel body coil...
August 10, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28802567/nano-sized-and-other-improved-reporters-for-magnetic-resonance-imaging-of-angiogenesis
#4
Simonetta Geninatti Crich, Enzo Terreno, Silvio Aime
Magnetic Resonance Imaging (MRI) enables to provide anatomical, functional and molecular information of pathological angiogenesis when used with properly tailored imaging probes. Functional studies have been the domain of Dynamic Contrast Enhancement (DCE) -MRI protocols from which it is possible to extract quantitative estimations on key parameters such as the volumes of vascular and extracellular compartments and the rates of the bidirectional exchange of the imaging reporters across the endothelial barrier...
August 9, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28802145/ensemble-of-expert-deep-neural-networks-for-spatio-temporal-denoising-of-contrast-enhanced-mri-sequences
#5
A Benou, R Veksler, A Friedman, T Riklin Raviv
Dynamic contrast-enhanced MRI (DCE-MRI) is an imaging protocol where MRI scans are acquired repetitively throughout the injection of a contrast agent. The analysis of dynamic scans is widely used for the detection and quantification of blood-brain barrier (BBB) permeability. Extraction of the pharmacokinetic (PK) parameters from the DCE-MRI concentration curves allows quantitative assessment of the integrity of the BBB functionality. However, curve fitting required for the analysis of DCE-MRI data is error-prone as the dynamic scans are subject to non-white, spatially-dependent and anisotropic noise...
August 2, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28797238/with-a-biomechanical-treatment-in-knee-osteoarthritis-less-knee-pain-did-not-correlate-with-synovitis-reduction
#6
Vikram Swaminathan, Matthew J Parkes, Michael J Callaghan, Terence W O'Neill, Richard Hodgson, Andrew D Gait, David T Felson
BACKGROUND: Braces are used to treat pain in patellofemoral joint osteoarthritis (PFJOA). In a trial, we previously reported pain improvement after 6-weeks brace use. The pain reduction did not correlate with changes in Magnetic Resonance Imaging (MRI) assessed Bone Marrow Lesion volume or static synovial volume. Studies show that changes in the synovium on dynamic contrast enhanced (DCE) MRI are more closely associated with symptom change than static synovial volume changes. We hypothesised change in synovitis assessed using dynamic imaging could explain the reduction in pain...
August 10, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28796620/transport-of-liposome-encapsulated-drugs-in-voxelized-computational-model-of-human-brain-tumors
#7
A Bhandari, A Bansal, A Singh, N Sinha
There are many obstacles to transport of chemotherapeutic drugs to tumor cells that lead to irregular and non-uniform uptake of drugs inside tumors. Study of these transport problems will help in accurate prediction of drug transport and optimizing treatment strategy. To this end, liposome mediated drug delivery has emerged as an excellent anticancer therapy due to its ability to deliver drugs at site of action and reducing the chances of side effects to the healthy tissues. In this study, a computational fluid dynamics (CFD) model based on realistic vasculature of human brain tumor is presented...
August 7, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28796069/assessment-of-therapeutic-response-in-crohn-s-disease-using-quantitative-dynamic-contrast-enhanced-mri-dce-mri-parameters-a-preliminary-study
#8
Jianguo Zhu, Faming Zhang, Jinfa Zhou, Haige Li
The aim of the study was to investigate dynamic contrast enhanced MRI (DCE-MRI) as a potential marker to assess the therapeutic responses of fecal microbiota transplantation (FMT) in patients with Crohn's disease (CD) and to determine the parameter or combination of parameters most strongly associated with changes in clinical indicators after treatment.In 22 CD patients, DCE-MRI was performed with a 3.0T scanner. Parameters of DCE-MRI (vascular transfer constant [K] and blood volume [BV]) in the terminal ileum were compared between before and day 90 after FMT treatment...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28790159/functional-imaging-and-circulating-biomarkers-of-response-to-regorafenib-in-treatment-refractory-metastatic-colorectal-cancer-patients-in-a-prospective-phase-ii-study
#9
Khurum Khan, Mihaela Rata, David Cunningham, Dow-Mu Koh, Nina Tunariu, Jens C Hahne, George Vlachogiannis, Somaieh Hedayat, Silvia Marchetti, Andrea Lampis, Mahnaz Darvish Damavandi, Hazel Lote, Isma Rana, Anja Williams, Suzanne A Eccles, Elisa Fontana, David Collins, Zakaria Eltahir, Sheela Rao, David Watkins, Naureen Starling, Jan Thomas, Eleftheria Kalaitzaki, Nicos Fotiadis, Ruwaida Begum, Maria Bali, Massimo Rugge, Eleanor Temple, Matteo Fassan, Ian Chau, Chiara Braconi, Nicola Valeri
OBJECTIVE: Regorafenib demonstrated efficacy in patients with metastatic colorectal cancer (mCRC). Lack of predictive biomarkers, potential toxicities and cost-effectiveness concerns highlight the unmet need for better patient selection. DESIGN: Patients with RAS mutant mCRC with biopsiable metastases were enrolled in this phase II trial. Dynamic contrast-enhanced (DCE) MRI was acquired pretreatment and at day 15 post-treatment. Median values of volume transfer constant (K(trans)), enhancing fraction (EF) and their product KEF (summarised median values of K(trans)× EF) were generated...
August 8, 2017: Gut
https://www.readbyqxmd.com/read/28790119/complementary-value-of-contralateral-parenchymal-enhancement-on-dce-mri-to-prognostic-models-and-molecular-assays-in-high-risk-er-her2-breast-cancer
#10
Bas H M van der Velden, Sjoerd G Elias, Tycho Bismeijer, Claudette E Loo, Max A Viergever, Lodewyk F A Wessels, Kenneth G A Gilhuijs
Purpose: To determine whether markers of healthy breast stroma are able to select a subgroup of patients at low risk of death or metastasis from patients considered at high risk according to routine markers of the tumor. <p>Experimental Design: Patients with ER-positive/HER2-negative breast cancer were consecutively included for retrospective analysis. The contralateral parenchyma was segmented automatically on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), whereupon the average of the top-10% late enhancement was calculated...
August 8, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28771446/micro-hccs-in-rats-with-liver-cirrhosis-paradoxical-effects-with-vascular-disrupting-agent-ca4p
#11
Yewei Liu, Ting Yin, Frederik De Keyzer, Yuanbo Feng, Feng Chen, Jianjun Liu, Shaoli Song, Jie Yu, Vincent Vandecaveye, Johan Swinnen, Guy Bormans, Uwe Himmelreich, Raymond Oyen, Jian Zhang, Gang Huang, Yicheng Ni
We sought to investigate anticancer efficacy of a vascular disrupting agent (VDA) combretastatin A-4 phosphate (CA4P) in relation to tumor size among hepatocellular carcinomas (HCCs) in rats using magnetic resonance imaging (MRI) and postmortem techniques. Nineteen rats with 43 chemically-induced HCCs of 2.8-20.9 mm in size on liver cirrhosis received CA4P intravenously at 10 mg/kg. Tumor-diameter was measured by T2-weighted imaging (T2WI) to define microcancers (< 5 mm) versus larger HCCs. Vascular responses and tissue necrosis were detected by diffusion-weighted imaging (DWI), contrast-enhanced T1-weighted imaging (CE-T1WI) and dynamic contrast enhanced (DCE-) MRI, which were validated by microangiography and histopathology...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28767583/percentage-change-of-primary-tumor-on-18f-fdg-pet-ct-as-a-prognostic-factor-for-invasive-ductal-breast-cancer-with-axillary-lymph-node-metastasis-comparison-with-mri
#12
Jang Yoo, Bom Sahn Kim, Jin Chung, Hai-Jeon Yoon
We evaluated the prognostic value of quantitative parameters using dual time point (DTP) F-FDG PET/CT (PET/CT) in invasive ductal breast cancer (IDC) with metastatic axillary lymph nodes (ALN) as compared with dynamic contrast-enhanced (DCE) and diffusion-weighted (DW) MRI.Seventy patients with IDC and metastatic ALN were retrospectively registered. Static PET parameters including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG) of primary tumor, SUVmax of ALN (SUVALN), and percentage changes (Δ%) in those parameters were measured with DTP PET/CT...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28766001/dynamic-contrast-enhanced-magnetic-resonance-imaging-parameters-correlate-with-advanced-revised-iss-and-angiopoietin-1-angiopoietin-2-ratio-in-patients-with-multiple-myeloma
#13
Evangelos Terpos, Dimitris Matsaridis, Vassilis Koutoulidis, Flora Zagouri, Dimitrios Christoulas, Sophia Fontara, Evangelia Panourgias, Maria Gavriatopoulou, Efstathios Kastritis, Meletios A Dimopoulos, Lia A Moulopoulos
The aim of the study was to assess the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with newly diagnosed multiple myeloma (MM) who were treated with novel anti-myeloma agents. We studied 60 previously untreated MM patients at diagnosis, 14 with smoldering MM (SMM) and 5 with MGUS. All patients underwent MRI of the thoracolumbar spine and pelvis before the administration of any kind of therapy, and DCE-MRI was performed. The MRI perfusion parameters evaluated were wash-in (WIN), washout (WOUT), time-to-peak (TTPK), time-to-maximum slope (TMSP), and the WIN/TMSP ratio...
August 1, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28763148/contribution-of-diffusion-weighted-imaging-to-dynamic-contrast-enhanced-mri-in-the-characterization-of-papillary-breast-lesions
#14
Seyma Yildiz, Huseyin Toprak, Yeliz Emine Ersoy, Fatma Ümit Malya, Ayşe Ahsen Bakan, Ayşe Aralaşmak, Zuhal Gucin
Papillary lesions have a broad spectrum of appearances on magnetic resonance imaging (MRI). The purpose of this study was to evaluate whether apparent diffusion coefficient (ADC) values of papillary lesions can be used to characterize lesion as benign or malignant. This retrospective study included 29 papillary lesions. Diagnostic values of dynamic contrast-enhanced MRI (DCE-MRI), DWI-ADC, and DCE-MRI plus DWI-ADC were separately calculated. The malignant papillary lesions (0.744×10(-3)  mm(2) /s) exhibited significantly lower mean ADC values than the benign lesions (1...
August 1, 2017: Breast Journal
https://www.readbyqxmd.com/read/28754853/dna-repair-deregulation-in-discrete-prostate-cancer-lesions-identified-on-multi-parametric-mri-and-targeted-by-mri-ultrasound-fusion-guided-biopsy
#15
Caleb R Dulaney, Soroush Rais-Bahrami, Debra Della Manna, Jennifer B Gordetsky, Jeffrey W Nix, Eddy S Yang
Prostate cancer is histologically and molecularly heterogeneous. Clinically significant disease is often driven by dominant intra-prostatic lesions (IPLs). Prostate cancers cluster into molecular phenotypes with substantial genetic heterogeneity making pathway-based molecular analysis appealing. MRI/ultrasound fusion biopsy provides a unique opportunity to characterize tumor biology of discrete lesions at diagnosis. This study determined the feasibility of pathway-based gene expression analysis of prostate biopsies and characterized cancer pathway deregulation...
July 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28753225/review-of-dynamic-contrast-enhanced-mri-technical-aspects-and-applications-in-the-musculoskeletal-system
#16
REVIEW
Parvinder Sujlana, Jan Skrok, Laura M Fayad
Although postcontrast imaging has been used for many years in musculoskeletal imaging, dynamic contrast enhanced (DCE) MRI is not routinely used in many centers around the world. Unlike conventional contrast-enhanced sequences, DCE-MRI allows the evaluation of the temporal pattern of enhancement in the musculoskeletal system, perhaps best known for its use in oncologic applications (such as differentiating benign from malignant tumors, evaluating for treatment response after neoadjuvant chemotherapy, and differentiating postsurgical changes from residual tumor)...
July 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28751444/pediatric-phase-1-trial-and-pharmacokinetic-study-of-trebananib-in-relapsed-solid-tumors-advl1115-a-children-s-oncology-group-phase-1-consortium-report
#17
Sarah E S Leary, Julie R Park, Joel M Reid, Andrew T Ralya, Sylvain Baruchel, Bing Wu, Timothy P L Roberts, Xiaowei Liu, Charles G Minard, Elizabeth Fox, Brenda J Weigel, Susan Blaney
Trebananib is a first-in-class anti-angiogenic peptibody (peptide-Fc fusion protein) that inhibits Angiopoietin 1 and 2. A pediatric phase 1 trial was performed to define trebananib dose limiting toxicities (DLT), recommended phase 2 dose (RP2D) and pharmacokinetics (PK).<br /><br />Experimental Design: Trebananib was administered by weekly infusion. Three dose levels (10, 15 or 30 mg/kg/dose) were evaluated using a rolling-six design. Part 2 evaluated a cohort of subjects with primary central nervous system (CNS) tumors...
July 27, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28744320/quantification-of-tumor-vascular-permeability-and-blood-volume-by-positron-emission-tomography
#18
Haojun Chen, Xiao Tong, Lixin Lang, Orit Jacobson, Bryant C Yung, Xiangyu Yang, Ruiliang Bai, Dale O Kiesewetter, Ying Ma, Hua Wu, Gang Niu, Xiaoyuan Chen
Purpose: Evans Blue (EB) is an azo dye that binds quantitatively with serum albumin. With an albumin binding, NOTA conjugated truncated Evan's blue (NEB) dye derived PET tracer, we aimed to establish a strategy for evaluating vascular permeability in malignant tumors via non-invasive PET. Experimental design: Sixty-minute dynamic PET using [(18)F]FAl-NEB was performed in three xenograft tumor models including INS-1 rat insulinoma, UM-SCC-22B human head and neck carcinoma and U-87 MG human glioblastoma. Tumor vascular permeability was quantified by the difference of the slopes between tumor and blood time-activity curve (TACs, expressed as Ps )...
2017: Theranostics
https://www.readbyqxmd.com/read/28740447/breast-dynamic-contrast-enhanced-mri-fibrocystic-changes-presenting-as-a-non-mass-enhancement-mimicking-malignancy
#19
Zorica C Milosevic, Mirjan M Nadrljanski, Zorka M Milovanovic, Nina Z Gusic, Slavko S Vucicevic, Olga S Radulovic
BACKGROUND: We aimed to analyse the morphokinetic features of breast fibrocystic changes (nonproliferative lesions, proliferative lesions without atypia and proliferative lesions with atypia) presenting as a non-mass enhancement (NME)in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) examination. PATIENTS AND METHODS: Forty-six patients with histologically proven fibrocystic changes (FCCs) were retrospectively reviewed, according to Breast Imaging Reporting and Data System (BI-RADS) lexicon...
June 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28733632/3d-anatomical-and-perfusion-mri-for-longitudinal-evaluation-of-biomaterials-for-bone-regeneration-of-femoral-bone-defect-in-rats
#20
Emeline J Ribot, Clement Tournier, Rachida Aid-Launais, Neha Koonjoo, Hugo Oliveira, Aurelien J Trotier, Sylvie Rey, Didier Wecker, Didier Letourneur, Joelle Amedee Vilamitjana, Sylvain Miraux
Magnetic Resonance Imaging (MRI) appears as a good surrogate to Computed Tomography (CT) scan as it does not involve radiation. In this context, a 3D anatomical and perfusion MR imaging protocol was developed to follow the evolution of bone regeneration and the neo-vascularization in femoral bone defects in rats. For this, three different biomaterials based on Pullulan-Dextran and containing either Fucoidan or HydroxyApatite or both were implanted. In vivo MRI, ex vivo micro-CT and histology were performed 1, 3 and 5 weeks after implantation...
July 21, 2017: Scientific Reports
keyword
keyword
39759
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"