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https://www.readbyqxmd.com/read/29149906/forebrain-specific-conditional-silencing-of-staufen2-alters-synaptic-plasticity-learning-and-memory-in-rats
#1
Stefan M Berger, Iván Fernández-Lamo, Kai Schönig, Sandra M Fernández Moya, Janina Ehses, Rico Schieweck, Stefano Clementi, Thomas Enkel, Sascha Grothe, Oliver von Bohlen Und Halbach, Inmaculada Segura, José María Delgado-García, Agnès Gruart, Michael A Kiebler, Dusan Bartsch
BACKGROUND: Dendritic messenger RNA (mRNA) localization and subsequent local translation in dendrites critically contributes to synaptic plasticity and learning and memory. Little is known, however, about the contribution of RNA-binding proteins (RBPs) to these processes in vivo. RESULTS: To delineate the role of the double-stranded RBP Staufen2 (Stau2), we generate a transgenic rat model, in which Stau2 expression is conditionally silenced by Cre-inducible expression of a microRNA (miRNA) targeting Stau2 mRNA in adult forebrain neurons...
November 17, 2017: Genome Biology
https://www.readbyqxmd.com/read/29144070/food-safety-program-performance-assessment-in-tennessee-2003-2011
#2
Heather Henderson, Lori LeMaster, John Dunn
To assess food safety program performance, the Tennessee Department of Health conducted food service surveys of randomly selected establishments and reviewed routine inspection reports by environmental health specialists (EHSs) of the same facilities. The individual restaurant sanitation scores, along with types and frequencies of violations noted by the survey team, were compared with records from the previous year. In addition, EHSs were observed as they each performed two routine inspections. Survey team staff consistently marked more critical violations than did field EHS staff...
March 2017: Journal of Environmental Health
https://www.readbyqxmd.com/read/29095276/outcome-and-risk-factors-associated-with-extent-of-central-nervous-system-injury-due-to-exertional-heat-stroke
#3
Mengmeng Yang, Zhi Li, Yan Zhao, Feihu Zhou, Yu Zhang, Jingli Gao, Ting Yin, Xin Hu, Zhi Mao, Jianguo Xiao, Li Wang, Chao Liu, Liqiong Ma, Zhihao Yuan, Jianfei Lv, Haoliang Shen, Peter C Hou, Hongjun Kang
To explore the relationship between the extent of central nervous system (CNS) injury and patient outcomes meanwhile research the potential risk factors associated with neurologic sequelae. In this retrospective cohort study, we analyzed data from 117 consecutive patients (86 survivors, 31 nonsurvivors) with exertional heat stroke (EHS) who had been admitted to intensive care unit (ICU) at 48 Chinese hospitals between April 2003 and July 2015. Extent of CNS injury was dichotomized according to Glasgow coma scale (GCS) score (severe 3-8, not severe 9-15)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29095274/comparison-of-the-effects-of-extracorporeal-shock-wave-therapy-and-a-vacuum-erectile-device-on-penile-erectile-dysfunction-a-randomized-clinical-trial
#4
RANDOMIZED CONTROLLED TRIAL
Tao Qi, Lei Ye, Bo Wang, Bin Zhang, Jun Chen
BACKGROUND: This randomized clinical trial (October 2012-December 2013) compared extracorporeal shock wave therapy (ESWT) and a vacuum erectile device (VED) for management of erectile dysfunction (ED). METHODS: Consecutive Chinese patients (20-55 years) with ED, abnormal nocturnal penile tumescence and rigidity (NPTR), and international index of erectile function-5 items (IIEF-5) score <22 were randomized to receive ESWT or VED (twice weekly, 4 weeks). Primary outcomes were treatment efficacy and success rate 4 weeks after completion of therapy...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29047457/effects-of-penile-fracture-and-its-surgical-treatment-on-psychosocial-and-sexual-function
#5
M S Bolat, M Özen, K Önem, A Açıkgöz, R Asci
The current therapy for penile fracture is immediate surgical repair, but sexual and psychosocial effects of the repair have been poorly investigated. We aimed to assess the impact of surgical correction of penile fracture on psychosocial status, sexual function, and erectile quality. Sixty-four patients classified into two subgroups according to follow-up: 2-24 months (Group 1), and longer than 24 months (Group 2), and 28 healthy men (Control group). The mean overall follow-up period was 39.1±32.7 months...
November 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28967058/topical-alprostadil-vitaros%C3%A2-in-the-treatment-of-erectile-dysfunction-after-non-nerve-sparing-robot-assisted-radical-prostatectomy
#6
Pier Andrea Della Camera, Simone Morselli, Gianmartin Cito, Giovanni Tasso, Nicola Laruccia, Andrea Cocci, Antonio Ruffo, Mauro Gacci, Sergio Serni, Marco Carini, Alessandro Natali
OBJECTIVE: The aim of the study is the evaluation of the efficacy and safety of the treatment with topical alprostadil (Vitaros©) in post-robot assisted radical prostatectomy (RARP) rehabilitation therapy of patients with erectile dysfunction (ED). METHODS: Seventy-four patients were enrolled and underwent non-nerve-sparing RARP. Inclusion criteria: age <75, preoperatively International Index of Erectile Function (IIEF-5) >16, erection hardness score (EHS) ≥2, weekly sexual intercourse ≥1, affirmative answers to Sexual Encounter Profile Question (SEP-Q) 2 and SEP-Q3, Charlson Comorbidity Index (CCI) ≤5, Eastern Cooperative Oncology Group (ECOG) performance status ≤1, no moderate/severe cardiovascular disease...
September 22, 2017: Urologia
https://www.readbyqxmd.com/read/28962876/low-intensity-extracorporeal-shock-wave-therapy-for-erectile-dysfunction-a-systematic-review-and-meta-analysis
#7
Libo Man, Guizhong Li
OBJECTIVE: To use systematic review and meta-analysis to assess the efficacy of low-energy extracorporeal shockwave therapy (LI-ESWT) for erectile dysfunction (ED) was undertaken with a meta-analysis to identify the efficacy of the treatment modality. METHODS: A comprehensive search of the PubMed, Cochrane Register and Embase databases to March 2017 was performed for randomized controlled trials reporting on patients with ED treated with LI- ESWT. The International Index of Erectile Function (IIEF) and the Erection Hardness Score (EHS) were the most commonly used tools to evaluate the therapeutic efficacy of LI-ESWT...
September 26, 2017: Urology
https://www.readbyqxmd.com/read/28944292/early-head-start-pediatric-dental-use-and-oral-health-related-quality-of-life
#8
J M Burgette, J S Preisser, M Weinberger, R S King, R G Rozier
The objective of the study was to examine the mediating effect of child dental use on the effectiveness of North Carolina Early Head Start (EHS) in improving oral health-related quality of life (OHRQoL). In total, 479 parents of children enrolled in EHS and 699 parents of Medicaid-matched children were interviewed at baseline when children were approximately 10 mo old and 24 mo later. In this quasi-experimental study, mediation analysis was performed using the counterfactual framework analysis, which employed 2 logit models with random effects: 1) for the mediator as a function of the treatment and covariates and 2) for the outcome as a function of the treatment, mediator, and covariates...
October 2017: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/28935827/short-term-dietary-curcumin-supplementation-reduces-gastrointestinal-barrier-damage-and-physiological-strain-responses-during-exertional-heat-stress
#9
Mandy C Szymanski, Trevor L Gillum, Lacey M Gould, David S Morin, Matthew R Kuennen
PURPOSE: This work investigated the effect of 3d of 500mg/d dietary curcumin supplementation on gastrointestinal (GI) barrier damage and systems-physiology responses to exertional heat stress in non-heat acclimated humans. METHODS: Eight participants ran (65%VO2max) for 60min in a Darwin® chamber (37°C/25%RH) two times (Curcumin/Placebo). Intestinal fatty acid binding protein (I-FABP) and associated pro-inflammatory (MCP-1, TNFα, IL-6) and anti-inflammatory (IL-1RA, IL-10) cytokines were assayed from plasma collected before (Pre), after (Post), 1hr (1-Post), and 4hrs after (4-Post) exercise...
September 21, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28910394/up-regulation-of-gap-junction-in-peripheral-blood-t-lymphocytes-contributes-to-the-inflammatory-response-in-essential-hypertension
#10
Xin Ni, Ai Wang, Liang Zhang, Li-Ya Shan, Hai-Chao Zhang, Li Li, Jun-Qiang Si, Jian Luo, Xin-Zhi Li, Ke-Tao Ma
Inflammation has been shown to play an important role in the mechanisms involved in the pathogenesis of hypertension. Connexins (Cxs)-based gap junction channels (GJCs) or hemichannels (HCs) are involved in the maintenance of homeostasis in the immune system. However, the role of Cx43-based channels in T-lymphocytes in mediating the immune response in essential hypertension is not fully understand. The present study was designed to investigate the role of Cxs-based channels in T lymphocytes in the regulation of hypertension-mediated inflammation...
2017: PloS One
https://www.readbyqxmd.com/read/28905416/sar-and-scan-time-optimized-3d-whole-brain-double-inversion-recovery-imaging-at-7t
#11
Eberhard D Pracht, Thorsten Feiweier, Philipp Ehses, Daniel Brenner, Alard Roebroeck, Bernd Weber, Tony Stöcker
PURPOSE: The aim of this project was to implement an ultra-high field (UHF) optimized double inversion recovery (DIR) sequence for gray matter (GM) imaging, enabling whole brain coverage in short acquisition times ( ≈5 min, image resolution 1 mm(3) ). METHODS: A 3D variable flip angle DIR turbo spin echo (TSE) sequence was optimized for UHF application. We implemented an improved, fast, and specific absorption rate (SAR) efficient TSE imaging module, utilizing improved reordering...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28890417/the-impact-of-vessel-size-orientation-and-intravascular-contribution-on-the-neurovascular-fingerprint-of-bold-bssfp-fmri
#12
Mario Gilberto Báez-Yánez, Philipp Ehses, Christian Mirkes, Philbert S Tsai, David Kleinfeld, Klaus Scheffler
Monte Carlo simulations have been used to analyze oxygenation-related signal changes in pass-band balanced steady state free precession (bSSFP) as well as in gradient echo (GE) and spin echo (SE) sequences. Signal changes were calculated for artificial cylinders and neurovascular networks acquired from the mouse parietal cortex by two-photon laser scanning microscopy at 1 μm isotropic resolution. Signal changes as a function of vessel size, blood volume, vessel orientation to the main magnetic field B0 as well as relations of intra- and extravascular and of micro- and macrovascular contributions have been analyzed...
September 8, 2017: NeuroImage
https://www.readbyqxmd.com/read/28884638/low-intensity-extracorporeal-shockwave-therapy-can-improve-erectile-function-in-patients-who-failed-to-respond-to-phosphodiesterase-type-5-inhibitors
#13
Chia-Chun Tsai, Chii-Jye Wang, Yung-Chin Lee, Yen-Ting Kuo, Hsiao-Hua Lin, Ching-Chia Li, Wen-Jeng Wu, Chia-Chu Liu
Managing patients with erectile dysfunction (ED) who failed to respond to phosphodiesterase type 5 inhibitors (PDE5is) is a challenging task. Recently, low-intensity extracorporeal shockwave therapy (LI-ESWT) was reported to improve ED by enhancing perfusion of the penis. The current study was performed to evaluate whether combined treatment with LI-ESWT and PDE5is can restore erectile function in patients who failed to respond to PDE5is alone. This was an open-label single-arm prospective study. ED patients with an erection hardness score (EHS) ≦2 under a maximal dosage of PDE5is were enrolled...
November 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28881497/therapies-for-advanced-stage-hepatocellular-carcinoma-with-macrovascular-invasion-or-metastatic-disease-a-systematic-review-and-meta-analysis
#14
REVIEW
Richard S Finn, Andrew X Zhu, Farah Wigdan, Jehad Almasri, Feras Zaiem, Larry J Prokop, Mohammad Hassan Murad, Khaled Mohammed
Hepatocellular carcinoma (HCC) is a complex disease most commonly arising in the background of chronic liver disease. In the past two decades there has been a significant increase in our understanding of both the clinical and molecular heterogeneity of HCC. There has been a robust increase in clinical trial activity in patients with poor prognostic factors such as macrovascular invasion and extrahepatic spread. We aimed to synthesize the evidence for the treatment of patients with advanced HCC based on these baseline characteristics including patients with both Child-Pugh scores of A and B...
September 7, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28879466/involvement-of-metabolic-components-volatile-compounds-pr-proteins-and-mechanical-strengthening-in-multilayer-protection-of-cucumber-plants-against-rhizoctonia-solani-activated-by-trichoderma-atroviride-trs25
#15
Justyna Nawrocka, U Małolepsza, K Szymczak, M Szczech
In the present study, the spread of Rhizoctonia solani-induced disease was limited when cucumber plants were pretreated with Trichoderma atroviride TRS25. The systemic disease suppression was related to TRS25-induced resistance (TISR) induction with simultaneous plant growth promotion. Protection of cucumber was related to enhanced activity of defense enzymes, e.g., guaiacol peroxidase (GPX), syringaldazine peroxidase (SPX), phenylalanine ammonia lyase (PAL), and polyphenol oxidase (PPO) as well as phenolic (PC) concentration increases in the conditions of hydrogen peroxide (H2O2) accumulation, resulting in thiobarbituric acid reactive substance (TBARS) decrease...
September 6, 2017: Protoplasma
https://www.readbyqxmd.com/read/28875350/enantioconvergent-hydrolysis-of-racemic-styrene-oxide-at-high-concentration-by-a-pair-of-novel-epoxide-hydrolases-into-r-phenyl-1-2-ethanediol
#16
Rui Wang, Die Hu, Xuncheng Zong, Jinping Li, Lei Ding, Minchen Wu, Jianfang Li
OBJECTIVES: To prepare (R)-phenyl-1,2-ethanediol ((R)-PED) with high enantiomeric excess (ee p) and yield from racemic styrene oxide (rac-SO) at high concentration by bi-enzymatic catalysis. RESULTS: The bi-enzymatic catalysis was designed for enantioconvergent hydrolysis of rac-SO by a pair of novel epoxide hydrolases (EHs), a Vigna radiata EH3 (VrEH3) and a variant (AuEH2(A250I)) of Aspergillus usamii EH2. The simultaneous addition mode of VrEH3 and AuEH2(A250I), exhibiting the highest average turnover frequency (aTOF) of 0...
September 5, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28810981/thermoregulatory-response-to-exercise-after-exertional-heat-stroke
#17
Emmanuel Sagui, Sophie Beighau, Arnaud Jouvion, Julie Trichereau, Delphine Cornet, René Charles Berthelot, Frédéric Canini, Laurent Grélot
BACKGROUND: After one episode of exertional heat stroke (EHS), risk factors must be identified to determine the potential for subsequent episodes. One of these risk factors, core body temperature (Tco) kinetics during strenuous exercise, may be a surrogate marker suggestive of impaired thermoregulation. This study aimed to determine the kinetics of increases in Tco among military subjects who had a history of EHS. METHODS: Forty subjects (38 males, mean age 28.4 ± 4...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28783460/engaging-parents-in-early-head-start-home-based-programs-how-do-home-visitors-do-this
#18
Caroline Shanti
Parental engagement is considered elemental to successful outcomes for parents and their children in early childhood home visiting programs. Engagement is that piece of parental involvement that refers to the working relationship between the parent and the home visitor. Multiple papers have called for research to pinpoint the ways in which home visitors work with parents to form these working relationships, and form partnerships to achieve positive outcomes. Analysis revealed that in individualizing their efforts to each family, home visitors follow semi-sequential steps in implementing engagement...
September 2017: Journal of Evidence-informed Social Work
https://www.readbyqxmd.com/read/28777927/carbohydrate-and-protein-intake-during-exertional-heat-stress-ameliorates-intestinal-epithelial-injury-and-small-intestine-permeability
#19
Rhiannon M J Snipe, Anthony Khoo, Cecilia M Kitic, Peter R Gibson, Ricardo J S Costa
Exertional heat stress (EHS) disturbs the integrity of the gastrointestinal tract leading to endotoxaemia and cytokinaemia, which have symptomatic and health implications. This study aimed to determine the effects of carbohydrate and protein intake during EHS on gastrointestinal integrity, symptoms, and systemic responses. Eleven (male, n = 6; female, n = 5) endurance runners completed 2 h of running at 60% maximal oxygen uptake in 35 °C ambient temperature on 3 occasions in randomised order, consuming water (WATER), 15 g glucose (GLUC), or energy-matched whey protein hydrolysate (WPH) before and every 20 min during EHS...
August 4, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28770494/cell-microencapsulation-in-polyethylene-glycol-hydrogel-microspheres-using-electrohydrodynamic-spraying
#20
Mozhdeh Imaninezhad, Era Jain, Silviya Petrova Zustiak
Microencapsulation of cells is beneficial for various biomedical applications, such as tissue regeneration and cell delivery. While a variety of techniques can be used to produce microspheres, electrohydrodynamic spraying (EHS) has shown promising results for the fabrication of cell-laden hydrogel microspheres in a wide range of sizes and in a relatively high-throughput manner. Here we describe an EHS technique for the fabrication of cell-laden polyethylene glycol (PEG) microspheres. We utilize mild hydrogel gelation chemistry and a combination of EHS parameters to allow for cell microencapsulation with high efficiency and viability...
August 3, 2017: Methods in Molecular Biology
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