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https://www.readbyqxmd.com/read/27909226/unique-cytokine-and-chemokine-responses-to-exertional-heat-stroke-in-mice
#1
Michelle A King, Lisa R Leon, Deborah A Morse, Thomas L Clanton
In heat stroke, cytokines are believed to play important roles in multi-organ dysfunction and recovery of damaged tissue. The time course of the cytokine response is well defined in passive heat stroke (PHS), but little is known about exertional heat stroke (EHS). In this study we used a recently developed mouse EHS model to measure the responses of circulating cytokines/chemokines and cytokine gene expression in muscle. A very rapid increase in circulating IL-6 was observed at max core temperature (Tc,max) that peaked at 0...
December 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27900794/fast-and-efficient-free-induction-decay-mr-spectroscopic-imaging-of-the-human-brain-at-9-4-tesla
#2
Grzegorz L Chadzynski, Jonas Bause, Gunamony Shajan, Rolf Pohmann, Klaus Scheffler, Philipp Ehses
PURPOSE: The purpose of this work was to develop a fast and efficient MRSI-FID acquisition scheme and test its performance in vivo. The aim was to find a trade-off between the minimal total acquisition time and signal-to-noise ratio of the acquired spectra. METHODS: Measurements were performed on a 9.4 Tesla system. Sequence optimization included redesign of water suppression, optimization of the sequence gradients, and improvement of the sampling efficiency by minimizing the read-out time...
November 29, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27796954/using-3d-culture-of-primary-mammary-epithelial-cells-to-define-molecular-entities-required-for-acinus-formation-analyzing-map-kinase-phosphatases
#3
Malgorzata Gajewska, Sara McNally
Three-dimensional (3D) cell cultures on reconstituted basement membrane (rBM) enable the study of complex interactions between extracellular matrix (ECM) components and epithelial cells, which are crucial for the establishment of cell polarity and functional development of epithelia. 3D cultures of mammary epithelial cells (MECs) on Matrigel (a laminin-rich ECM derived from the Engelbreth-Holm-Swarm (EHS) murine tumor) promote interactions of MECs with the matrix via integrins, leading to formation of spherical monolayers of polarized cells surrounding a hollow lumen (acini)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27795395/exported-epoxide-hydrolases-modulate-erythrocyte-vasoactive-lipids-during-plasmodium-falciparum-infection
#4
Natalie J Spillman, Varun K Dalmia, Daniel E Goldberg
: Erythrocytes are reservoirs of important epoxide-containing lipid signaling molecules, including epoxyeicosatrienoic acids (EETs). EETs function as vasodilators and anti-inflammatory modulators in the bloodstream. Bioactive EETs are hydrolyzed to less active diols (dihydroxyeicosatrienoic acids) by epoxide hydrolases (EHs). The malaria parasite Plasmodium falciparum infects host red blood cells (RBCs) and exports hundreds of proteins into the RBC compartment. In this study, we show that two parasite epoxide hydrolases, P falciparum epoxide hydrolases 1 (PfEH1) and 2 (PfEH2), both with noncanonical serine nucleophiles, are exported to the periphery of infected RBCs...
October 18, 2016: MBio
https://www.readbyqxmd.com/read/27789366/controlled-drug-release-from-hydrogels-for-contact-lenses-drug-partitioning-and-diffusion
#5
A F R Pimenta, J Ascenso, J C S Fernandes, R Colaço, A P Serro, B Saramago
Optimization of drug delivery from drug loaded contact lenses assumes understanding the drug transport mechanisms through hydrogels which relies on the knowledge of drug partition and diffusion coefficients. We chose, as model systems, two materials used in contact lens, a poly-hydroxyethylmethacrylate (pHEMA) based hydrogel and a silicone based hydrogel, and three drugs with different sizes and charges: chlorhexidine, levofloxacin and diclofenac. Equilibrium partition coefficients were determined at different ionic strength and pH, using water (pH 5...
October 24, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27738568/liver-transplantation-after-exertional-heatstroke-induced-acute-liver-failure
#6
Faisal Inayat, Hafeez Ul Hasan Virk
Exertional heatstroke (EHS) is a life-threatening disease characterized clinically by central nervous system dysfunction and severe hyperthermia. It frequently occurs among athletes, soldiers, and laborers. While cardiopulmonary symptoms are common in patients undergoing EHS, irreversible acute liver failure is a rarely described phenomenon. When managing cases of EHS complicated by acute liver failure, it is crucial to act promptly with aggressive total body cooling in order to prevent progression of the clinical syndrome...
September 6, 2016: Curēus
https://www.readbyqxmd.com/read/27715394/orphan-g-protein-coupled-receptor-gprc5a-modulates-integrin-%C3%AE-1-mediated-epithelial-cell-adhesion
#7
Daria R Bulanova, Yevhen A Akimov, Anne Rokka, Teemu D Laajala, Tero Aittokallio, Petri Kouvonen, Teijo Pellinen, Sergey G Kuznetsov
G-Protein Coupled Receptor (GPCR), Class C, Group 5, Member A (GPRC5A) has been implicated in several malignancies. The underlying mechanisms, however, remain poorly understood. Using a panel of human cell lines, we demonstrate that CRISPR/Cas9-mediated knockout and RNAi-mediated depletion of GPRC5A impairs cell adhesion to integrin substrates: collagens I and IV, fibronectin, as well as to extracellular matrix proteins derived from the Engelbreth-Holm-Swarm (EHS) mouse sarcoma (Matrigel). Consistent with the phenotype, knock-out of GPRC5A correlated with a reduced integrin β1 (ITGB1) protein expression, impaired phosphorylation of the focal adhesion kinase (FAK), and lower activity of small GTPases RhoA and Rac1...
October 7, 2016: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/27705730/erectile-function-recovery-after-robotic-assisted-radical-prostatectomy-rarp-long-term-exhaustive-analysis-across-all-preoperative-potency-categories
#8
Abdullah M Alenizi, Kevin C Zorn, Marc Bienz, Emad Rajih, Pierre Alain Hueber, Naif Al-Hathal, Serge Benayoun, Thierry Lebeau, Assaad El-Hakim
INTRODUCTION: To evaluate erectile function recovery following robotic-assisted radical prostatectomy (RARP) according to preoperative sexual health inventory for men (SHIM) score stratification. MATERIALS AND METHODS: We prospectively collected data on 250 consecutive patients who underwent RARP by a single surgeon between October 2006 and October 2012. Thirty-six patients were excluded because of lack of preoperative SHIM score. All patients had a minimum follow up of 2 years...
October 2016: Canadian Journal of Urology
https://www.readbyqxmd.com/read/27687595/differentiation-of-five-enterohepatic-helicobacter-species-by-nested-pcr-with-high-resolution-melting-curve-analysis
#9
Miaoli Wu, Dan Rao, Yujun Zhu, Jing Wang, Wen Yuan, Yu Zhang, Ren Huang, Pengju Guo
BACKGROUND: Enterohepatic Helicobacter species (EHS) are widespread in rodent species around the world. Several studies have demonstrated that infection with EHS can interfere with the outcomes of animal experiments in cancer research and significantly influence the study results. Therefore, it is essential to establish a rapid detection and identification of EHS for biomedical research using laboratory rodents. Our study aimed to develop a rapid and sensitive method to detect and distinguish five enterohepatic Helicobacter species...
September 30, 2016: Helicobacter
https://www.readbyqxmd.com/read/27663989/whole-brain-mp2rage-based-mapping-of-the-longitudinal-relaxation-time-at-9-4t
#10
G E Hagberg, J Bause, T Ethofer, P Ehses, T Dresler, C Herbert, R Pohmann, G Shajan, A Fallgatter, M A Pavlova, K Scheffler
Mapping of the longitudinal relaxation time (T1) with high accuracy and precision is central for neuroscientific and clinical research, since it opens up the possibility to obtain accurate brain tissue segmentation and gain myelin-related information. An ideal, quantitative method should enable whole brain coverage within a limited scan time yet allow for detailed sampling with sub-millimeter voxel sizes. The use of ultra-high magnetic fields is well suited for this purpose, however the inhomogeneous transmit field potentially hampers its use...
September 21, 2016: NeuroImage
https://www.readbyqxmd.com/read/27659062/depth-dependence-of-visual-signals-in-the-human-superior-colliculus-at-9-4-t
#11
Joana R Loureiro, Gisela E Hagberg, Thomas Ethofer, Michael Erb, Jonas Bause, Philipp Ehses, Klaus Scheffler, Marc Himmelbach
The superior colliculus (SC) is a layered structure located in the midbrain. We exploited the improved spatial resolution and BOLD signal strength available at 9.4 T to investigate the depth profile of visual BOLD responses in the human SC based on distortion-corrected EPI data with a 1 mm isotropic resolution. We used high resolution (350 µm in-plane) anatomical images to determine regions-of-interest of the SC and applied a semi-automated method to segment it into superficial, intermediate, and deep zones...
September 23, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27632869/can-temperate-water-immersion-effectively-reduce-rectal-temperature-in-exertional-heat-stroke-situations-a-critically-appraised-topic
#12
Tyler T Truxton, Kevin C Miller
Clinical Scenario Exertional heat stroke (EHS) is a medical emergency which, if left untreated, can result in death. The standard of care for EHS patients includes confirmation of hyperthermia via rectal temperature (Trec) and then immediate cold-water immersion (CWI). While CWI is the fastest way to reduce Trec,(1,2) it may be difficult to lower and maintain water bath temperature in the recommended ranges (1.7°C-15°C [35°F-59°F])(1) because of limited access to ice and/or the bath being exposed to high ambient temperatures for long periods of time...
August 24, 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27632849/should-cooling-vests-be-used-to-treat-exertional-heatstroke-a-critically-appraised-topic
#13
Megan L Keen, Kevin C Miller
: Clinical Scenario: Exercise performed in hot and humid environments increases core body temperature (TC). If TC exceeds 40°C for prolonged periods of time, exertional heat stroke (EHS) may occur. EHS is one of the leading causes of sudden death in athletes. Mortality and morbidity increase the longer the patient's TC remains above 40°C; thus, it is imperative to initiate cooling as quickly as possible. "Acceptable" cooling rates in EHS situations are between 0.08°C·min-1 and 0.15°C·min-1 while "ideal" cooling rates are above 0...
August 24, 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27598296/maintenance-of-hepatic-functions-in-primary-human-hepatocytes-cultured-on-xeno-free-and-chemical-defined-human-recombinant-laminins
#14
Masaaki Watanabe, Helen Zemack, Helene Johansson, Louise Hagbard, Carl Jorns, Meng Li, Ewa Ellis
Refined methods for maintaining specific functions of isolated hepatocytes under xeno-free and chemical defined conditions is of great importance for the development of hepatocyte research and regenerative therapy. Laminins, a large family of heterotrimeric basement membrane adhesion proteins, are highly cell and tissue type specific components of the extracellular matrix and strongly influence the behavior and function of associated cells and/or tissues. However, detailed biological functions of many laminin isoforms are still to be evaluated...
2016: PloS One
https://www.readbyqxmd.com/read/27589666/evaluation-of-an-oral-health-education-session-for-early-head-start-home-visitors
#15
Kevin Glatt, Christopher Okunseri, Diane Flanagan, Pippa Simpson, Yumei Cao, Earnestine Willis
OBJECTIVES: Home visiting programs promote the education and health of Early Head Start (EHS) children and pregnant women. However, EHS's oral health component is unevenly implemented. We conducted an educational intervention to improve oral health knowledge and motivational interviewing techniques among Wisconsin EHS home visitors. METHODS: A questionnaire assessing oral health-related knowledge and confidence was administered to home visitors before and after an educational session...
June 2016: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/27570092/erectile-function-after-treatment-for-rhabdomyosarcoma-of-prostate-and-bladder
#16
S Frees, P Rubenwolf, C Ziesel, J Faber, P Gutjahr, A Grossmann, J W Thüroff, R Stein
INTRODUCTION: Rhabdomyosarcoma (RMS) accounts for 5% of all pediatric tumors; 15-20% of these tumors are located in the urogenital tract, mostly originating from the prostate or bladder. In the light of the steadily improving prognosis for patients with RMS through interdisciplinary-multimodal study protocols with 60-70% long-term survivors, non oncological aspects such as erectile function (EF) have become increasingly important. The aim of this study was to evaluate EF in patients having undergone treatment for RMS of the bladder and prostate...
August 1, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27552398/first-generation-latina-mothers-experiences-of-supplementing-home-based-early-head-start-with-the-attachment-and-biobehavioral-catch-up-program
#17
Elizabeth M Aparicio, Nicole Denmark, Lisa J Berlin, Brenda Jones Harden
This qualitative pilot study examined first-generation Latina mothers' experiences of supplementing home-based Early Head Start (EHS) services with the evidence-based Attachment and Biobehavioral Catch-up (ABC; M. Dozier, O. Lindheim, & J. Ackerman, 2005) program. Ten low-income, first-generation Latina mothers with infants and toddlers enrolled in home-based EHS were provided 10 ABC home visits by a supplemental parent coach. Following delivery of ABC, mothers participated in in-depth, semistructured, qualitative interviews about their experiences...
September 2016: Infant Mental Health Journal
https://www.readbyqxmd.com/read/27539411/ion-transfer-between-ion-source-and-mass-spectrometer-inlet-electro-hydrodynamic-simulation-and-experimental-validation
#18
Xiaoyu Zhou, Zheng Ouyang
RATIONALE: The ion transfer from the atmospheric pressure ion source to mass spectrometer inlet is directly related to the sensitivity of the mass spectrometry (MS) analysis. Electric field and dynamic gas flow are typically used to facilitate the ionization process and ion transfer. While sophisticated methods have been developed for ion trajectory simulation with a pure electric field, the influence of the dynamic gas flow could not be easily incorporated for the study. METHODS: A nanoESI (electrospray ionization) source was set off-axis in front of an MS inlet to study the ion transfer under the influence of both electric field and gas flows...
August 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27523267/frameworks-and-tools-for-risk-assessment-of-manufactured-nanomaterials
#19
REVIEW
Danail Hristozov, Stefania Gottardo, Elena Semenzin, Agnes Oomen, Peter Bos, Willie Peijnenburg, Martie van Tongeren, Bernd Nowack, Neil Hunt, Andrea Brunelli, Janeck J Scott-Fordsmand, Lang Tran, Antonio Marcomini
Commercialization of nanotechnologies entails a regulatory requirement for understanding their environmental, health and safety (EHS) risks. Today we face challenges to assess these risks, which emerge from uncertainties around the interactions of manufactured nanomaterials (MNs) with humans and the environment. In order to reduce these uncertainties, it is necessary to generate sound scientific data on hazard and exposure by means of relevant frameworks and tools. The development of such approaches to facilitate the risk assessment (RA) of MNs has become a dynamic area of research...
October 2016: Environment International
https://www.readbyqxmd.com/read/27517655/initial-experience-with-pre-activation-of-the-cardiac-catheterization-lab-and-emergency-room-bypass-for-patients-with-st-elevation-myocardial-infarction-in-halifax-nova-scotia
#20
Adil Bata, Ata Ur Rehman Quraishi, Michael Love, Lawrence Title, Hussein Beydoun, Tony Lee, Najaf Nadeem, Bakhtiar Kidwai, Catherine Kells, Helen Curran
BACKGROUND: To determine whether pre-activation of the cardiac catheterization lab by Emergency Health Services (EHS) with a single call system in the field was associated with reduced time to reperfusion in patients with ST-Elevation Myocardial Infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). METHODS: Consecutive STEMI patients identified by EHS and subsequently taken to the Queen Elizabeth II Health Sciences Center (QEIIHSC) for PPCI between February 1, 2011 and January 30, 2013 were examined...
November 1, 2016: International Journal of Cardiology
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