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JOURNAL ARTICLE
Joachim Doua, Jesús Rodríguez-Baño, Rachel Froget, Padma Puranam, Oscar Go, Jeroen Geurtsen, Sanne van Rooij, Tuba Vilken, Inage Minoru, Izumi Yasumori, Bart Spiessens, Evelina Tacconelli, Lena M Biehl, Joshua T Thaden, Michal Sarnecki, Herman Goossens, Jan Poolman, Marc Bonten, Miquel Ekkelenkamp
BACKGROUND: Clinical data characterizing invasive Escherichia coli disease (IED) are limited. We assessed the clinical presentation of IED and antimicrobial resistance (AMR) patterns of causative E. coli isolates in older adults. METHODS: EXPECT-2 (NCT04117113) was a prospective, observational, multinational, hospital-based study conducted in patients with IED aged ≥ 60 years. IED was determined by the microbiological confirmation of E...
January 25, 2024: Infection
#22
REVIEW
Hany A Zaki, Soumaya Bensliman, Khalid Bashir, Haris Iftikhar, Mohamed H Fayed, Waleed Salem, Amr Elmoheen, Yavuz Yigit
BACKGROUND: Differentiating sepsis from non-infectious systemic inflammatory response syndrome (SIRS) is challenging. Biomarkers like procalcitonin (PCT) aid early risk assessment and guide antibiotic use. This study aims to ascertain PCT's accuracy as a sepsis biomarker among adult emergency department admissions. METHOD: The PRISMA guidelines were followed to search for relevant articles in five electronic databases between April 14th and August 4th, 2023: PubMed, Cochrane Library, ProQuest, EMBASEs, and ScienceDirect...
January 22, 2024: Systematic Reviews
#23
JOURNAL ARTICLE
Suma D Borra, Dnyanesh N Morkar
INTRODUCTION: Sepsis is a complicated host response to infection involving organ failure which ultimately causes death of the host. Procalcitonin (PCT) is an effective marker used to diagnose sepsis but until now, there has been no ideal marker for sepsis. Phospholipase A2 (PLA2) also increases infections; however, only a few studies have assessed its capacity as a biomarker to diagnose sepsis. Thus, we aimed to examine PLA2 and compare its diagnostic capacity and accuracy with PCT as a biomarker of sepsis...
December 2023: Curēus
#24
JOURNAL ARTICLE
Roberto Jabornisky, Nathan Kuppermann, Sebastián González-Dambrauskas
No abstract text is available yet for this article.
January 21, 2024: JAMA
#25
JOURNAL ARTICLE
Luregn J Schlapbach, R Scott Watson, Lauren R Sorce, Andrew C Argent, Kusum Menon, Mark W Hall, Samuel Akech, David J Albers, Elizabeth R Alpern, Fran Balamuth, Melania Bembea, Paolo Biban, Enitan D Carrol, Kathleen Chiotos, Mohammod Jobayer Chisti, Peter E DeWitt, Idris Evans, Cláudio Flauzino de Oliveira, Christopher M Horvat, David Inwald, Paul Ishimine, Juan Camilo Jaramillo-Bustamante, Michael Levin, Rakesh Lodha, Blake Martin, Simon Nadel, Satoshi Nakagawa, Mark J Peters, Adrienne G Randolph, Suchitra Ranjit, Margaret N Rebull, Seth Russell, Halden F Scott, Daniela Carla de Souza, Pierre Tissieres, Scott L Weiss, Matthew O Wiens, James L Wynn, Niranjan Kissoon, Jerry J Zimmerman, L Nelson Sanchez-Pinto, Tellen D Bennett
IMPORTANCE: Sepsis is a leading cause of death among children worldwide. Current pediatric-specific criteria for sepsis were published in 2005 based on expert opinion. In 2016, the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) defined sepsis as life-threatening organ dysfunction caused by a dysregulated host response to infection, but it excluded children. OBJECTIVE: To update and evaluate criteria for sepsis and septic shock in children...
January 21, 2024: JAMA
#26
JOURNAL ARTICLE
Abdullah M Algarni, Musa S Alfaifi, Ali A Al Bshabshe, Othman M Omair, Mohammed A Alsultan, Hasan M Alzahrani, Hadi E Alali, Abdullah A Alsabaani, Ali M Alqarni, Salah A Alghanem, Bandar S Al Mufareh, Ayesha M Almemari, Abdulrahman A Sindi, Ibrahim U Ozturan, Abdullah A Alhadhira, Asaad S Shujaa, Abdullah H Alotaibi, Moosa M Awladthani, Ahmed A Alsaad, Abdullah A Almarshed, AlHanouv M AlQahtani, Tim R Harris, Bader A Alyahya, Saad A Assiri, Feras H Abuzeyad, Sara N Kazim, Abdulrahman A Al-Fares, Faisal Y Almazroua, Naif T Marzook, Abdullah A Basri, Abdallah M Elsafti, Abdulaziz S Alalshaikh, Cansu A Özturan, Yousef I Alawad, Awad AlOmari, Malek A Alkhateeb, Moonis M Farooq, Latifa Ali AlMutairi, Muneera M Alasfour, Mohammad I Al Haber, Umma-Kulthum A Umar, Nidal H Bokhary, Saeed F Alqahtani, Abdulrhman Almutairi, Hisham F Alyahya, Wejdan S Alzahrani, Fawziah Alsalmi, Abdulmajeed M Omair, Faysal M Alasmari, Sultan Y Alfifi, Mohammed S Al-Nujimi, Farid Foroutan
BACKGROUND: Early identification of a patient with infection who may develop sepsis is of utmost importance. Unfortunately, this remains elusive because no single clinical measure or test can reflect complex pathophysiological changes in patients with sepsis. However, multiple clinical and laboratory parameters indicate impending sepsis and organ dysfunction. Screening tools using these parameters can help identify the condition, such as SIRS, quick SOFA (qSOFA), National Early Warning Score (NEWS), or Modified Early Warning Score (MEWS)...
2024: PloS One
#27
JOURNAL ARTICLE
Emma Viikinkoski, Jenni Aittokallio, Joonas Lehto, Helena Ollila, Arto Relander, Tuija Vasankari, Juho Jalkanen, Jarmo Gunn, Sirpa Jalkanen, Juhani Airaksinen, Maija Hollmén, Tuomas O Kiviniemi
OBJECTIVES: Cardiac surgery induces systemic inflammatory response syndrome (SIRS), leading to higher morbidity and mortality. There are no individualized predictors for worse outcomes or biomarkers for the multifactorial, excessive inflammatory response. The interest of this study was to evaluate whether a systematic use of the SIRS criteria could be used to predict postoperative outcomes beyond infection and sepsis, and if the development of an exaggerated inflammation response could be observed preoperatively...
December 18, 2023: Journal of Cardiothoracic and Vascular Anesthesia
#28
Furkhan Ali, JinJin Wu, Dilip Kc
Serratia marcescens is a bacterial pathogen that tends to cause opportunistic infections, mainly in immune-compromised patients. In this case, we present a 69-year-old female who presented to the emergency department (ED) at Mount Sinai Hospital in Chicago on February 11th, 2022, after a mechanical fall. She had a medical history of metastatic lung cancer treated with chemotherapy, hypertension, pulmonary embolism, polysubstance abuse, and chronic obstructive pulmonary disease (COPD). The patient was found to be positive for systemic inflammatory response syndrome (SIRS)...
December 2023: Curēus
#29
REVIEW
Tania Marx, Nada Khelifi, Isabelle Xu, Laurie Ouellet, Annie Poirier, Benoit Huard, Myriam Mallet, Frédéric Bergeron, Maurice Boissinot, Michel G Bergeron, Simon Berthelot
OBJECTIVE: To identify tools that predict the risk of complications for patients presenting to an outpatient clinic or an emergency department (ED) with influenza-like illness. METHODS: We searched Medline, Embase, Cochrane Library and CINAHL from inception to July 2023. We included articles reporting on the derivation or validation of a score or algorithm used to stratify the risk of hospitalization or mortality among patients with influenza-like illness in the ED or outpatient clinic...
January 15, 2024: Heliyon
#30
JOURNAL ARTICLE
Kyle Schuchter, Donna M Shuler Truoccolo, William S Wilson, Greta Anton
BACKGROUND: Intravenous (IV) vancomycin is commonly used to treat a variety of infections caused by methicillin-resistant Staphylococcus aureus (MRSA). The practice of administering a single dose of IV vancomycin prior to emergency department (ED) discharge may be clinically ineffective and foster antimicrobial resistance. Furthermore, this practice introduces an unnecessary infection risk along with preventable adverse effects while potentially increasing ED length of stay (LOS). There is a paucity of literature identifying patient characteristics and objective findings in this patient population, which may foster future antimicrobial stewardship initiatives in the ED...
December 3, 2023: American Journal of Emergency Medicine
#31
JOURNAL ARTICLE
Gaden Osborne, Olivia Valenti, Juniella Jarvis, Evelynne Wentzel, Jorge Vidaurre, Dave F Clarke, Anup D Patel
BACKGROUND AND OBJECTIVES: The American Academy of Neurology has developed quality measures related to various neurologic disorders. A gap exists in the implementation of these measures in the different health care systems. To date, there has been no electronic health care record nor implementation of quality measures in Antigua. Therefore, we aimed to increase the percent of patients who have epilepsy quality measures documented using standardized common data elements in the outpatient neurology clinic at Sir Lester Bird Medical Center from 0% to 80% per week by June 1, 2022 and sustain for 6 months...
February 2024: Neurology. Clinical Practice
#32
JOURNAL ARTICLE
Salma Binzaqr, Frederic Debordeaux, Jean-Frédéric Blanc, Panteleimon Papadopoulos, Elif Hindie, Bruno Lapouyade, Jean-Baptiste Pinaquy
Hepatocellular carcinoma (HCC) is one of the most common neoplasms worldwide and the third most common cause of cancer-related death. Several liver-targeted intra-arterial therapies are available for unresectable HCC, including selective internal radiation therapy (SIRT) and trans-arterial chemoembolization (TACE). Those two are the most used treatment modalities in localized non-operable HCC. TACE is the treatment option for patients with stage B, according to the BCLC staging system. In contrast, SIRT does not have an official role in the treatment algorithm, but recent studies showed promising outcomes in patients treated with SIRT...
December 1, 2023: Pharmaceuticals
#33
REVIEW
Lin Lan, Meichi Zhou, Xiaoli Chen, Min Dai, Ling Wang, Hong Li
BACKGROUND: In recent years, some studies classified patients with sepsis and predicted their mortality by using some evaluation scales. Several studies reported significant differences in the predictive values of several tools, and the non-uniformity of the cut-off value. OBJECTIVE: To determine and compare the prognostic accuracy of Sequential Organ Failure Assessment (SOFA) score, Modified Early Warning Score (MEWS), and Systemic Inflammatory Response Syndrome (SIRS) criteria in predicting the mortality of patients with sepsis...
December 21, 2023: Nursing in Critical Care
#34
JOURNAL ARTICLE
Elliott K Main, Matt Fuller, Vesela P Kovacheva, Rania Elkhateb, Kristen Azar, Morgan Caldwell, Vanna Chiem, Mindy Foster, Ronald Gibbs, Brenna L Hughes, Rebecca Johnson, Nobin Kottukapally, Magdalena Sanz Cortes, Melissa G Rosenstein, Laurence E Shields, Sylvia Sudat, Caitlin D Sutton, Paloma Toledo, Austin Traylor, Kurt Wharton, Melissa E Bauer
OBJECTIVE: To evaluate the screening performance characteristics of existing tools for the diagnosis of sepsis during delivery admissions. METHODS: This was a case-control study using electronic health record data, including vital signs and laboratory results, for all delivery admissions of patients with sepsis from 59 nationally distributed hospitals. Patients with sepsis were matched by gestational age at delivery in a 1:4 ratio with patients without sepsis to create a comparison group...
December 12, 2023: Obstetrics and Gynecology
#35
JOURNAL ARTICLE
Melissa E Bauer, Matt Fuller, Vesela Kovacheva, Rania Elkhateb, Kristen Azar, Morgan Caldwell, Vanna Chiem, Mindy Foster, Ronald Gibbs, Brenna L Hughes, Rebecca Johnson, Nobin Kottukapally, Melissa G Rosenstein, Magdalena Sanz Cortes, Laurence E Shields, Sylvia Sudat, Caitlin D Sutton, Paloma Toledo, Austin Traylor, Kurt Wharton, Elliott Main
OBJECTIVE: To evaluate the performance characteristics of existing screening tools for the prediction of sepsis during antepartum and postpartum readmissions. METHODS: This was a case-control study using electronic health record data obtained between 2016 and 2021 from 67 hospitals for antepartum sepsis admissions and 71 hospitals for postpartum readmissions up to 42 days. Patients in the sepsis case group were matched in a 1:4 ratio to a comparison cohort of patients without sepsis admitted antepartum or postpartum...
December 12, 2023: Obstetrics and Gynecology
#36
JOURNAL ARTICLE
Finn Syryca, Costanza Pellegrini, Tobias Rheude, Florian Zobel, Katharina Kornhuber, Erion Xhepa, N Patrick Mayr, Hector A Alvarez-Covarrubias, Stefan Holdenrieder, Heribert Schunkert, Christian Thilo, Adnan Kastrati, Michael Joner
BACKGROUND: Data on systemic inflammatory response syndrome (SIRS) after transcatheter aortic valve implantation (TAVI) are scarce and limited to small cohorts. We aimed to investigate its incidence and mid-term impact in a large cohort of TAVI patients. METHODS: From January 2018 to December 2020, 717 patients with severe aortic valve stenosis undergoing TAVI were included. SIRS was defined as fulfilling at least two of the following criteria within 48 h from the procedure: leucocyte count >12...
November 30, 2023: Cardiovascular Revascularization Medicine: Including Molecular Interventions
#37
JOURNAL ARTICLE
Weidong Zhang, Jiapei Xie, Hongjian Liu, Meiyun Wang
OBJECTIVE: We compared the signal intensity ratio (SIR) of the cochlear basal turn between Meniere's disease and healthy controls to investigate potential damage of the blood-labyrinth barrier in Meniere's disease. METHODS: Thirty patients diagnosed with unilateral definite Meniere's disease and 24 healthy controls were enrolled. 3D-FLAIR scan was conducted to assess the grades of endolymphatic hydrops in Meniere's patients while measuring the SIR of cochlear basal turns in both groups...
December 6, 2023: European Archives of Oto-rhino-laryngology
#38
JOURNAL ARTICLE
Julian Wong, Kenneth K Lau
PURPOSE: Primary epiploic appendagitis (PEA) is not an uncommon cause of abdominal pain. The systemic inflammatory response syndrome (SIRS) criteria have high sensitivity for early detection of inflammation and infection. To date, there is limited data about the association between SIRS and PEA. The aims of this retrospective study were to evaluate the prevalence of SIRS response and its clinical relevance in patients diagnosed with PEA within a large tertiary hospital network. METHODS: A retrospective study was performed on all consecutive adult patients who presented to four major emergency departments with CT-confirmed PEA from 01 January 2022 to 27 March 2023...
December 5, 2023: Emergency Radiology
#39
JOURNAL ARTICLE
Joseph Boscia, Heather X Rhodes, Thomas Sanders, Saptarshi Biswas
Background and objective Facial fractures represent a growing concern among an aging population prone to falls. In light of this, this study aimed to investigate differential facial fracture patterns and outcomes based on age effects. Determining the differences between the severity and type of facial fractures in populations of different ages will help guide clinical decision-making when managing patients with facial fractures. Methods This was a single-center study involving trauma registry data, from July 1, 2016, to January 31, 2022...
November 2023: Curēus
#40
JOURNAL ARTICLE
Zhehao Xiao, Pingping Xiao, Yong Wang, Chen Fang, Yong Li
The incidence of cancer in acromegaly patients may be higher than that in the general population, although this has not been fully elucidated yet. This study analyzed the risk of various important types of cancer in acromegaly patients. The study was registered in INPLASY (registration number: INPLASY202340037). The PubMed, Web of Science, and EMBASE databases were searched for studies based on strict inclusion and exclusion criteria, from the time of database inception up to June 30, 2022. All observational studies of acromegaly patients with cancer were included, without language restrictions...
2023: PloS One
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