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https://www.readbyqxmd.com/read/29772166/pixel-counting-of-fluorescence-spots-triggered-by-dna-walkers-for-ultrasensitive-quantification-of-nucleic-acid
#1
Longyi Zhu, Qihui Liu, Bangyu Yang, Huangxian Ju, Jianping Lei
A pixel counting strategy is designed based on DNA walker-triggered fluorescence spots for ultrasensitive detection of nucleic acid. The two-dimensional DNA walker was constructed by hybridization of the dye-labeled hairpin structure (hDNA) as track and swing strand (sDNA) as DNAzyme with two types of capture DNAs covalently modified by click chemistry on glass slide. Introduction of target DNA unlocked the sDNA via strand displacement to form the activated DNAzyme, and the latter cut nearby hDNA with Mn2+ as cofactor, resulting in fluorescence recovery of dye-labeled hDNA on the substrate due to the separation from the quencher...
May 17, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29764283/minimally-invasive-thread-trigger-digit-release-a-preliminary-report-on-34-digits-of-the-adult-hands
#2
Danqing Guo, Logan McCool, Alexander Senk, Brionn Tonkin, Joseph Guo, Rachel M Lytie, Danzhu Guo
The trigger finger release was performed in 34 digits (11 thumbs and 23 fingers) of 24 patients through the thread transecting technique with the tip-to-tip approach, in which a 22-gauge needle inserts into a 18-gauge needle when both needles are inside the hand, guiding the 22-gauge needle to exit the hand at the same access point of 18-gauge needle. We prospectively evaluated the effectiveness and functional recovery of these patients. In all 34 digits, triggering and locking were resolved, and complete extension and flexion occurred immediately following the release...
January 1, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29734896/different-dosages-of-triamcinolone-acetonide-injection-for-the-treatment-of-trigger-finger-and-thumb-a-randomized-controlled-trial
#3
Arkaphat Kosiyatrakul, Wittawat Loketkrawee, Suriya Luenam
BACKGROUND: This study was designed to compare the efficacy and complications between 3 different dosages of triamcinolone acetonide for the treatment of trigger finger. METHODS: Ninety-three patients with a total of 120 trigger digits were included in the study. The involved digits were randomized to 3 groups. Each group received treatment consisting of injection with 5, 10 or 20 mg triamcinolone acetonide. The clinical response to the steroid was evaluated during the first six weeks after injection...
June 2018: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29717435/basic-concepts-and-validation-of-digital-pcr-measurements
#4
Leonardo Pinheiro, Kerry R Emslie
Use of digital polymerase chain reaction (dPCR) technology is rapidly growing and diversifying into a range of areas in life science. The release of dPCR commercial systems has facilitated access, leading to recognition of the potential advantages compared to previous quantitative PCR technologies, and the scope for novel applications. The capability of dPCR to deliver unprecedented levels of precision, accuracy, and resolution in quantification of nucleic acids has triggered a strong interest by academia and the life sciences industry in use of this technology as a molecular diagnostic tool...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29703931/transient-peak-strain-matching-partially-recovers-the-age-impaired-mechanoadaptive-cortical-bone-response
#5
Behzad Javaheri, Alessandra Carriero, Maria Wood, Roberto De Souza, Peter D Lee, Sandra Shefelbine, Andrew A Pitsillides
Mechanoadaptation maintains bone mass and architecture; its failure underlies age-related decline in bone strength. It is unclear whether this is due to failure of osteocytes to sense strain, osteoblasts to form bone or insufficient mechanical stimulus. Mechanoadaptation can be restored to aged bone by surgical neurectomy, suggesting that changes in loading history can rescue mechanoadaptation. We use non-biased, whole-bone tibial analyses, along with characterisation of surface strains and ensuing mechanoadaptive responses in mice at a range of ages, to explore whether sufficient load magnitude can activate mechanoadaptation in aged bone...
April 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29694014/indigoid-photoswitches-visible-light-responsive-molecular-tools
#6
Christian Petermayer, Henry Dube
Indigoid photoswitches comprise a class of chromophores that are derived from the parent and well-known indigo dye. Different from most photoswitches their core structures absorb in the visible region of the spectrum in both isomeric states even without substitutions, which makes them especially interesting for applications not tolerant of high-energy UV light. Also different from most current photoswitching systems, they provide highly rigid structures that undergo large yet precisely controllable geometry changes upon photoisomerization...
April 25, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29684707/targeting-mitochondria-esters-of-rhodamine-b-with-triterpenoids-are-mitocanic-triggers-of-apoptosis
#7
Ratna Kancana Wolfram, Lucie Heller, René Csuk
Triterpenoic acids, ursolic acid (1), oleanolic acid (2), glycyrrhetinic acid (3) and betulinic acid (4) were converted into their corresponding methyl 5-8 and benzyl esters 9-12 or benzyl amides 21-24. These derivatives served as starting materials for the synthesis of pink colored rhodamine B derivatives 25-36 which were screened for cytotoxicity in colorimetric SRB assays. All of the compounds were cytotoxic for a variety of human tumor cell lines. The activity of the benzyl ester derivatives 29-32 was lower than the cytotoxicity of the methyl esters 25-28...
April 17, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29680907/nlrp3-inflammasome-activation-regulates-aged-rbc-clearance
#8
Li Qin, Zhao Fengyong, Zhang Jiamin, Yang Qixiu, Lu Geming, Xia Rongwei, Zhu Ziyan
The NLR family pyrin domain-containing protein 3 (NLRP3) inflammasome is triggered by various stimuli. Whether the NLRP3 inflammasome is activated during the monocyte clearing of aged or damaged erythrocytes is unknown. This work aimed to determine whether the NLRP3 inflammasome is activated during the THP-1 cell engulfing of aged erythrocytes. In the study, THP-1 cells were treated with PMA and then coincubated with untreated red blood cells (RBCs), 42 °C-treated RBCs, immunoglobulin G (IgG) anti-D-sensitized RBCs, Rhnull/Rhmod RBC sample, hemoglobin, and RBC ghost...
April 21, 2018: Inflammation
https://www.readbyqxmd.com/read/29674234/spiking-neural-networks-for-handwritten-digit-recognition-supervised-learning-and-network-optimization
#9
Shruti R Kulkarni, Bipin Rajendran
We demonstrate supervised learning in Spiking Neural Networks (SNNs) for the problem of handwritten digit recognition using the spike triggered Normalized Approximate Descent (NormAD) algorithm. Our network that employs neurons operating at sparse biological spike rates below 300Hz achieves a classification accuracy of 98.17% on the MNIST test database with four times fewer parameters compared to the state-of-the-art. We present several insights from extensive numerical experiments regarding optimization of learning parameters and network configuration to improve its accuracy...
April 6, 2018: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29671018/topographic-anatomical-landmarks-for-pulley-system-of-the-thumb
#10
Dhivyalakshmi Gnanasekaran, Raveendranath Veeramani, Aravindhan Karuppusamy
PURPOSE: Knowledge of anatomical landmark to pulley system of the thumb is essential in successful treatment of trigger thumb release either by percutaneous or by minimally invasive technique. Though surgical release of trigger thumb is done commonly, there is paucity of data in the literature regarding its surface landmarks. The purpose of this study is to identify palmar surface anatomical landmarks to the pulley system of the thumb. METHODS: Dissection was performed on 55 fresh frozen adult cadaveric thumbs...
April 18, 2018: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29667081/the-schultz-midi-benchmarking-toolbox-for-midi-interfaces-percussion-pads-and-sound-cards
#11
Benjamin G Schultz
The Musical Instrument Digital Interface (MIDI) was readily adopted for auditory sensorimotor synchronization experiments. These experiments typically use MIDI percussion pads to collect responses, a MIDI-USB converter (or MIDI-PCI interface) to record responses on a PC and manipulate feedback, and an external MIDI sound module to generate auditory feedback. Previous studies have suggested that auditory feedback latencies can be introduced by these devices. The Schultz MIDI Benchmarking Toolbox (SMIDIBT) is an open-source, Arduino-based package designed to measure the point-to-point latencies incurred by several devices used in the generation of response-triggered auditory feedback...
April 17, 2018: Behavior Research Methods
https://www.readbyqxmd.com/read/29666912/magnetic-bead-capture-dna-glucose-loaded-nanoliposomes-for-amplifying-the-glucometer-signal-in-the-rapid-screening-of-hepatitis-c-virus-rna
#12
Haijian Tu, Kun Lin, Yongzhi Lun, Liuming Yu
A digital detection strategy based on a portable personal glucometer (PGM) was developed for the simple, rapid, and sensitive detection of hepatitis C virus (HCV) RNA, involving the release of glucose-loaded nanoliposomes due to coupling-site-specific cleavage by the endonuclease BamHI. The glucose-loaded nanoliposomes were synthesized using a reversed-phase evaporation method and provided an amplified signal at the PGM in the presence of HCV RNA. Initially, a 21-mer oligonucleotide complementary to HCV RNA was covalently conjugated to a magnetic bead through the amino group at the 5' end of the oligonucleotide, and then bound to a glucose-loaded liposome by typical carbodiimide coupling at its 3' end...
April 17, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29660140/time-course-of-the-photochemical-reflectance-index-pri-during-photosynthetic-induction-its-relationship-with-the-photochemical-yield-of-photosystem-ii
#13
Keach Murakami, Yasuomi Ibaraki
Time courses of photochemical reflectance index (PRI) of an attached cucumber leaf during a dark-light transition were compared to those of photochemical yields of photosystem II (YII ) to discuss the feasibility of PRI imaging for estimating the efficiency of photosynthetic light use. YII and PRI were simultaneously evaluated with a pulse-amplitude modulation chlorophyll fluorometer and a low-cost imaging system consisted of digital cameras and band-pass filters, respectively. YII decreased immediately after the transition and then increased under various photon flux densities...
April 16, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29651162/quantitative-methods-to-monitor-rna-biomarkers-in-myotonic-dystrophy
#14
Marzena Wojciechowska, Krzysztof Sobczak, Piotr Kozlowski, Saam Sedehizadeh, Agnieszka Wojtkowiak-Szlachcic, Karol Czubak, Robert Markus, Anna Lusakowska, Anna Kaminska, J David Brook
Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are human neuromuscular disorders associated with mutations of simple repetitive sequences in affected genes. The abnormal expansion of CTG repeats in the 3'-UTR of the DMPK gene elicits DM1, whereas elongated CCTG repeats in intron 1 of ZNF9/CNBP triggers DM2. Pathogenesis of both disorders is manifested by nuclear retention of expanded repeat-containing RNAs and aberrant alternative splicing. The precise determination of absolute numbers of mutant RNA molecules is important for a better understanding of disease complexity and for accurate evaluation of the efficacy of therapeutic drugs...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29642639/influence-of-waveform-characteristics-on-lidar-ranging-accuracy-and-precision
#15
Xiaolu Li, Bingwei Yang, Xinhao Xie, Duan Li, Lijun Xu
Time of flight (TOF) based light detection and ranging (LiDAR) is a technology for calculating distance between start/stop signals of time of flight. In lab-built LiDAR, two ranging systems for measuring flying time between start/stop signals include time-to-digital converter (TDC) that counts time between trigger signals and analog-to-digital converter (ADC) that processes the sampled start/stop pulses waveform for time estimation. We study the influence of waveform characteristics on range accuracy and precision of two kinds of ranging system...
April 10, 2018: Sensors
https://www.readbyqxmd.com/read/29621236/automated-plant-species-identification-trends-and-future-directions
#16
REVIEW
Jana Wäldchen, Michael Rzanny, Marco Seeland, Patrick Mäder
Current rates of species loss triggered numerous attempts to protect and conserve biodiversity. Species conservation, however, requires species identification skills, a competence obtained through intensive training and experience. Field researchers, land managers, educators, civil servants, and the interested public would greatly benefit from accessible, up-to-date tools automating the process of species identification. Currently, relevant technologies, such as digital cameras, mobile devices, and remote access to databases, are ubiquitously available, accompanied by significant advances in image processing and pattern recognition...
April 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29619360/how-many-trigger-fingers-resolve-spontaneously-without-any-treatment
#17
Daniel McKee, Jan Lalonde, Don Lalonde
Introduction: There is very little information in the literature evaluating the natural history of adult trigger fingers and their rate of spontaneous resolution over time. Methods: A consecutive case series of patients with trigger finger was generated. For each patient, we recorded whether the patient's disease resolved from either no treatment versus active treatment options and over what time period. Results: Three hundred forty-three patients with trigger finger were included in the study...
February 2018: Plastic Surgery
https://www.readbyqxmd.com/read/29618454/development-of-whole-slide-imaging-on-smartphones-and-evaluation-with-thinprep-cytology-test-samples-follow-up-study
#18
Yu-Ning Huang, Xing-Chun Peng, Shuoxin Ma, Hong Yu, Yu-Biao Jin, Jun Zheng, Guo-Hui Fu
BACKGROUND: The smartphone-based whole slide imaging (WSI) system represents a low-cost and effective alternative to automatic scanners for telepathology. In a previous study, the development of one such solution, named scalable whole slide imaging (sWSI), was presented and analyzed. A clinical evaluation of its iOS version with 100 frozen section samples verified the diagnosis-readiness of the produced virtual slides. OBJECTIVE: The first aim of this study was to delve into the quantifying issues encountered in the development of an Android version...
April 4, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29603251/community-water-fluoridation-online-an-analysis-of-the-digital-media-ecosystem
#19
Mohammad Helmi, Mary Kate Spinella, Brittany Seymour
OBJECTIVES: Research demonstrates the safety and efficacy of community water fluoridation (CWF). Yet, the digitization of communication has triggered the spread of inaccurate information online. The purpose of this study was to analyze patterns of CWF information dissemination by a network of sources on the web. METHODS: We used Media Cloud, a searchable big data platform of over 550 million stories from 50 thousand sources, along with tools to analyze that archive...
March 30, 2018: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/29601625/proximal-subungual-onychomycosis-in-the-immunocompetent-a-case-report-and-review-of-the-literature
#20
Sydney E Liang, David E Cohen, Evan A Rieder
Proximal subungual onychomycosis (PSO), which predominantly involves the nail plate from the proximal nail fold, is the rarest form of onychomycosis. Classically associated with an immunocompromised state, PSO is an uncommon diagnosis in individuals without immunodeficiency. We present a case of a healthy 51-year-old man, who presented with a three-month history of white discoloration of multiple toenails. Physical examination revealed white, opaque patches on the proximal third nail plates of multiple toenails...
April 1, 2018: Journal of Drugs in Dermatology: JDD
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