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https://www.readbyqxmd.com/read/29304851/development-of-the-excitation-contraction-coupling-machinery-and-its-relation-to-myofibrillogenesis-in-human-ipsc-derived-skeletal-myocytes
#1
Jeanne Lainé, Gunnar Skoglund, Emmanuel Fournier, Nacira Tabti
BACKGROUND: Human induced pluripotent stem cells-derived myogenic progenitors develop functional and ultrastructural features typical of skeletal muscle when differentiated in culture. Besides disease-modeling, such a system can be used to clarify basic aspects of human skeletal muscle development. In the present study, we focus on the development of the excitation-contraction (E-C) coupling, a process that is essential both in muscle physiology and as a tool to differentiate between the skeletal and cardiac muscle...
January 5, 2018: Skeletal Muscle
https://www.readbyqxmd.com/read/29300763/food-words-distract-the-hungry-evidence-of-involuntary-semantic-processing-of-task-irrelevant-but-biologically-relevant-unexpected-auditory-words
#2
Fabrice B R Parmentier, Antonia P Pacheco-Unguetti, Sara Valero
Rare changes in a stream of otherwise repeated task-irrelevant sounds break through selective attention and disrupt performance in an unrelated visual task by triggering shifts of attention to and from the deviant sound (deviance distraction). Evidence indicates that the involuntary orientation of attention to unexpected sounds is followed by their semantic processing. However, past demonstrations relied on tasks in which the meaning of the deviant sounds overlapped with features of the primary task. Here we examine whether such processing is observed when no such overlap is present but sounds carry some relevance to the participants' biological need to eat when hungry...
2018: PloS One
https://www.readbyqxmd.com/read/29290504/conservative-management-of-trigger-finger-a-systematic-review
#3
Dianna Lunsford, Kristin Valdes, Selena Hengy
STUDY DESIGN: Systematic review INTRODUCTION: Trigger finger (TF) is a common condition in the hand. The primary purpose of this systematic review was to evaluate the current evidence to determine the efficacy of orthotic management of TF. A secondary purpose was to identify the characteristics of the orthotic management. The tertiary purpose of this study was to ascertain if the studies used a patient-reported outcome to assess gains from the patient's perspective. METHODS: All studies including randomized controlled trials, prospective, and retrospective cohort studies were included in this review due to limited high-level evidence...
December 28, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29273679/the-hoxd-cluster-is-a-dynamic-and-resilient-tad-boundary-controlling-the-segregation-of-antagonistic-regulatory-landscapes
#4
Eddie Rodríguez-Carballo, Lucille Lopez-Delisle, Ye Zhan, Pierre J Fabre, Leonardo Beccari, Imane El-Idrissi, Thi Hanh Nguyen Huynh, Hakan Ozadam, Job Dekker, Denis Duboule
The mammalian HoxD cluster lies between two topologically associating domains (TADs) matching distinct enhancer-rich regulatory landscapes. During limb development, the telomeric TAD controls the early transcription of Hoxd genes in forearm cells, whereas the centromeric TAD subsequently regulates more posterior Hoxd genes in digit cells. Therefore, the TAD boundary prevents the terminal Hoxd13 gene from responding to forearm enhancers, thereby allowing proper limb patterning. To assess the nature and function of this CTCF-rich DNA region in embryos, we compared chromatin interaction profiles between proximal and distal limb bud cells isolated from mutant stocks where various parts of this boundary region were removed...
December 22, 2017: Genes & Development
https://www.readbyqxmd.com/read/29250273/left-atrial-appendage-characteristics-in-patients-with-persistent-atrial-fibrillation-undergoing-catheter-ablation-laapaf-study
#5
Enes E Gul, Usama Boles, Sohaib Haseeb, Justin Flood, Ayuish Bansal, Benedict Glover, Damian Redfearn, Chris Simpson, Hoshiar Abdollah, Adrian Baranchuk, Kevin A Michael
Background: Despite technological and scientific efforts, the recurrence rate of persistent atrial fibrillation (AF) remains high. Several studies have shown that in addition to pulmonary vein (PV) isolation other non-PV triggers, particularly left atrial appendage may be the source of initiation and maintenance of AF. There are few studies showing the role of left atrial appendage (LAA) isolation in order to obtain higher success rate in persistent AF patients. Objective: We analyzed the LAA volume, volume index and shape relative to the LA in patients with persistent AF undergoing AF ablation...
February 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29239268/a-community-perspective-on-bowel-management-and-quality-of-life-after-spinal-cord-injury-the-influence-of-autonomic-dysreflexia
#6
Jessica A Inskip, Vera-Ellen M Lucci, Maureen S McGrath, Rhonda Willms, Victoria E Claydon
Autonomic dysfunction is common in individuals with spinal cord injury (SCI) and leads to numerous abnormalities, including profound cardiovascular and bowel dysfunction. In those with high level lesions, bowel management is a common trigger for autonomic dysreflexia (AD, hypertension provoked by sensory stimuli below the level of injury). Improving bowel care is integral for enhancing quality of life (QoL). We aimed to describe the relationships between bowel care, AD, and QoL in individuals with SCI. We performed an online community survey of individuals living with SCI (n=287; injury levels C1-sacral)...
December 14, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29218291/congenital-bilateral-multiple-trigger-fingers-in-a-5-year-old-child
#7
Neeraj Bhaban, Maksud Devale, Amarnath Munoli
Paediatric bilateral multiple trigger fingers are extremely rare. The underlying etiopathogenesis and hence the surgical principles of management of trigger finger in children are different from those of pediatric trigger thumb and adult trigger finger. In this paper, we report the case of a 5 year old girl with congenital trigger digits involving the middle, ring and little fingers of both hands. She did not have any episode of trauma, viral or bacterial infections or any metabolic disorder. Following lack of any improvement with a physiotherapy and a splintage regime for 6 weeks, we offered surgical management for the affected digits...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29210892/physiologically-triggered-digital-cognitive-aid-facilitates-crisis-management-in-a-simulated-operating-room-a-randomized-controlled-study
#8
Jonathan Lipps, Lori Meyers, Scott Winfield, Michael Durda, Vedat Yildiz, Michael Kushelev
INTRODUCTION: Although the benefits of using cognitive aids in anesthesia care have previously been demonstrated, several challenges remain. It must be presented in a timely manner, and providers must be amenable to using the tool once it is available. We hypothesized that anesthesia residents would perform superiorly when presented with a digital cognitive aid (DCogA) that is automatically triggered by a set vital sign aberration. METHODS: Thirty anesthesia residents were randomized to either control (with access to hard copy of the cognitive aid) or receive a DCogA projected on their anesthesia information management system with the onset of heart block and associated hypotension...
November 28, 2017: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/29197654/exploring-viral-reservoir-the-combining-approach-of-cell-sorting-and-droplet-digital-pcr
#9
REVIEW
Lara Gibellini, Simone Pecorini, Sara De Biasi, Marcello Pinti, Elena Bianchini, Anna De Gaetano, Margherita Digaetano, Rosalberta Pullano, Domenico Lo Tartaro, Anna Iannone, Cristina Mussini, Andrea Cossarizza, Milena Nasi
Combined antiretroviral therapy (cART) blocks different steps of HIV replication and maintains plasma viral RNA at undetectable levels. The virus can remain in long-living cells and create a reservoir where HIV can restart replicating after cART discontinuation. A persistent viral production triggers and maintains a persistent immune activation, which is a well-known feature of chronic HIV infection, and contributes either to precocious aging, or to the increased incidence of morbidity and mortality of HIV positive patients...
November 29, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29191438/real-time-eeg-defined-excitability-states-determine-efficacy-of-tms-induced-plasticity-in-human-motor-cortex
#10
Christoph Zrenner, Debora Desideri, Paolo Belardinelli, Ulf Ziemann
BACKGROUND: Rapidly changing excitability states in an oscillating neuronal network can explain response variability to external stimulation, but if repetitive stimulation of always the same high- or low-excitability state results in long-term plasticity of opposite direction has never been explored in vivo. OBJECTIVE/HYPOTHESIS: Different phases of the endogenous sensorimotor μ-rhythm represent different states of corticospinal excitability, and repetitive transcranial magnetic stimulation (rTMS) of always the same high- vs...
November 24, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29190506/mammographic-density-and-breast-cancer-risk-in-breast-screening-assessment-cases-and-women-with-a-family-history-of-breast-cancer
#11
Stephen W Duffy, Oliver W E Morrish, Prue C Allgood, Richard Black, Maureen G C Gillan, Paula Willsher, Julie Cooke, Karen A Duncan, Michael J Michell, Hilary M Dobson, Roberta Maroni, Yit Y Lim, Hema N Purushothaman, Tamara Suaris, Susan M Astley, Kenneth C Young, Lorraine Tucker, Fiona J Gilbert
BACKGROUND: Mammographic density has been shown to be a strong independent predictor of breast cancer and a causative factor in reducing the sensitivity of mammography. There remain questions as to the use of mammographic density information in the context of screening and risk management, and of the association with cancer in populations known to be at increased risk of breast cancer. AIM: To assess the association of breast density with presence of cancer by measuring mammographic density visually as a percentage, and with two automated volumetric methods, Quantra™ and VolparaDensity™...
January 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29179110/land-defend-an-innovative-database-structure-for-landslides-and-floods-and-their-consequences
#12
Elisabetta Napolitano, Ivan Marchesini, Paola Salvati, Marco Donnini, Cinzia Bianchi, Fausto Guzzetti
Information on historical landslides and floods - collectively called "geo-hydrological hazards - is key to understand the complex dynamics of the events, to estimate the temporal and spatial frequency of damaging events, and to quantify their impact. A number of databases on geo-hydrological hazards and their consequences have been developed worldwide at different geographical and temporal scales. Of the few available database structures that can handle information on both landslides and floods some are outdated and others were not designed to store, organize, and manage information on single phenomena or on the type and monetary value of the damages and the remediation actions...
November 24, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29168381/cellular-biosensors-with-engineered-genetic-circuits
#13
Behide Saltepe, Ebru Sahin Kehribar, Side Selin Su Yirmibesoglu, Urartu Ozgur Safak Seker
: An increasing interest in building novel biological devices with designed cellular functionalities has triggered the search of innovative tools for biocomputation. Utilizing the tools of synthetic biology, numerous genetic circuits have been imple-mented such as engineered logic operation in analog and digital circuits. Whole cell biosensors are widely used biological devices that employ several biocomputation tools to program cells for desired functions. Up to date, a wide range of whole-cell biosensors have been designed and implemented for disease theranostics, biomedical applications and environmental monitoring...
November 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29150192/thirty-day-reoperation-and-or-admission-after-elective-hand-surgery-in-adults-a%C3%A2-10-year-review
#14
Avi D Goodman, Joseph A Gil, Adam M Starr, Edward Akelman, Arnold-Peter C Weiss
PURPOSE: Whereas acute complications following elective hand surgery have been assumed to be rare, the incidence of 30-day unplanned reoperation and/or admission for the most common elective procedures has not been well described. Our goal was to calculate the incidence and identify the risk factors associated with these complications in a busy academic practice. METHODS: Our institution's quality assurance database was examined retrospectively for unplanned reoperations and/or admissions within 30 days in adults undergoing elective procedures with 2 senior attending surgeons from February 2006 to January 2016...
November 15, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29131646/multifunctional-material-with-efficient-optoelectronic-integrated-molecular-switches-based-on-a-flexible-thin-film-crystal
#15
Chang Xu, Wan-Ying Zhang, Qiong Ye, Da-Wei Fu
Switchable materials, due to their potential applications in the fields of sensors, photonic devices, digital processing, etc., have been developed drastically. However, they still face great challenges in effectively inducing multiple molecular switching. Herein organic-inorganic hybrid compounds, an emerging class of hydrosoluble optoelectronic-active materials, welcome a new member with smart unique optical/electrical (fluorescence/dielectric) dual switches (switching ON/OFF), that is, [C5H13NBr][Cd3Br7] (1) in the form of both a bulk crystal and an ultraflexible monodirectional thin film, which simultaneously exhibits fast dielectric/fluorescent dual switching triggered by an optical/thermal/electric signal with a high signal-to-noise ratio of 35 (the highest one in the known optical/dielectric dual molecular switches)...
November 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29117820/carpal-tunnel-syndrome-and-trigger-wrist-caused-by-localized-amyloidosis-a-case-report
#16
Takuma Wakasugi, Ritsuro Shirasaka, Toshiyuki Kawauchi, Koji Fujita, Atsushi Okawa
We report a case of carpal tunnel syndrome and trigger wrist caused by localized amyloidosis. A 37-year-old man, who worked as a manufacturer, presented with a 5-month history of tingling sensation in the three radial fingers of the left hand and a painful click at the volar aspect of the wrist during digital motion. We divided the transverse carpal ligament and detected diffuse tenosynovitis that was especially severe around the flexor digitorum profundus tendons. Histological findings led to a diagnosis of amyloidosis...
December 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29058341/multichannel-wearable-fnirs-eeg-system-for-long-term-clinical-monitoring
#17
Ali Kassab, Jérôme Le Lan, Julie Tremblay, Phetsamone Vannasing, Mahya Dehbozorgi, Philippe Pouliot, Anne Gallagher, Frédéric Lesage, Mohamad Sawan, Dang Khoa Nguyen
Continuous brain imaging techniques can be beneficial for the monitoring of neurological pathologies (such as epilepsy or stroke) and neuroimaging protocols involving movement. Among existing ones, functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG) have the advantage of being noninvasive, nonobstructive, inexpensive, yield portable solutions, and offer complementary monitoring of electrical and local hemodynamic activities. This article presents a novel system with 128 fNIRS channels and 32 EEG channels with the potential to cover a larger fraction of the adult superficial cortex than earlier works, is integrated with 32 EEG channels, is light and battery-powered to improve portability, and can transmit data wirelessly to an interface for real-time display of electrical and hemodynamic activities...
October 23, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29055964/the-safety-of-percutaneous-trigger-digit-release-increased-by-neurovascular-displacement-with-local-hydraulic-dilatation-an-anatomical-and-clinical-study
#18
Honggang Wang, Ping Wang, Obioma Amajoyi, Clark J Chen, Gary Y Chen
BACKGROUND Although percutaneous trigger digit release is common, controversy exists regarding its safety. The purpose of this study was to evaluate the feasibility and safety of the neurovascular displacement by local hydraulic dilatation (LHD) during percutaneous trigger digit release. MATERIAL AND METHODS Ten cadaver hands with 50 digits were dissected in this anatomical study. The distance between bilateral neurovascular bundles in each digit was measured before LHD and after LHD. The difference between the measured data before LHD and those after LHD in the same digit was compared to assess the feasibility of the neurovascular displacement by LHD...
October 22, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29041234/simultaneous-generation-of-multiple-vector-beams-on-a-single-slm
#19
Carmelo Rosales-Guzmán, Nkosiphile Bhebhe, Andrew Forbes
Complex vector light fields, classically entangled in polarization and phase, have become ubiquitous in a wide variety of research fields. This has triggered the demonstration of a wide variety of generation techniques. Of particular relevance are those based on computer-controlled devices due to their great flexibility. In particular, spatial light modulators have demonstrated their high capabilities to generate any vector beam, with various spatial profiles and polarization distributions. Here, we put forward a novel technique that exploits the superposition principle in optics to enable the simultaneous generation of many vector beams using a single digital hologram...
October 16, 2017: Optics Express
https://www.readbyqxmd.com/read/29039199/dielectric-breakdown-in-chemical-vapor-deposited-hexagonal-boron-nitride
#20
Lanlan Jiang, Yuanyuan Shi, Fei Hui, Kechao Tang, Qian Wu, Chengbin Pan, Xu Jing, Hasan Uppal, Felix Palumbo, Guangyuan Lu, Tianru Wu, Haomin Wang, Marco A Villena, Xiaoming Xie, Paul C McIntyre, Mario Lanza
Insulating films are essential in multiple electronic devices because they can provide essential functionalities, such as capacitance effects and electrical fields. Two-dimensional (2D) layered materials have superb electronic, physical, chemical, thermal, and optical properties, and they can be effectively used to provide additional performances, such as flexibility and transparency. 2D layered insulators are called to be essential in future electronic devices, but their reliability, degradation kinetics, and dielectric breakdown (BD) process are still not understood...
November 1, 2017: ACS Applied Materials & Interfaces
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