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https://www.readbyqxmd.com/read/28644937/predictors-of-recurrence-after-corticosteroid-injection-for-trigger-digits
#1
Louis C Grandizio, Amy Speeckaert, Justin Brothers, Jove Graham, Joel C Klena
BACKGROUND: We aimed to identify risk factors for recurrence of trigger digit following corticosteroid injection. METHODS: A retrospective review identified patients 18 years and older who presented to a single fellowship-trained hand surgeon with a symptomatic trigger digit during a 1-year period. Baseline demographic data were recorded. Patients with persistent trigger digit after a single injection were offered a second injection. Patients refusing a second injection were excluded from our analysis...
July 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28558098/complex-and-dynamic-chromosomal-rearrangements-in-a-family-with-seemingly-non-mendelian-inheritance-of-dopa-responsive-dystonia
#2
Katja Lohmann, Claire Redin, Holger Tönnies, Susan B Bressman, Jose Ignacio Martin Subero, Karin Wiegers, Frauke Hinrichs, Yorck Hellenbroich, Aleksandar Rakovic, Deborah Raymond, Laurie J Ozelius, Eberhard Schwinger, Reiner Siebert, Michael E Talkowski, Rachel Saunders-Pullman, Christine Klein
Importance: Chromosomal rearrangements are increasingly recognized to underlie neurologic disorders and are often accompanied by additional clinical signs beyond the gene-specific phenotypic spectrum. Objective: To elucidate the causal genetic variant in a large US family with co-occurrence of dopa-responsive dystonia as well as skeletal and eye abnormalities (ie, ptosis, myopia, and retina detachment). Design, Setting, and Participants: We examined 10 members of a family, including 5 patients with dopa-responsive dystonia and skeletal and/or eye abnormalities, from a US tertiary referral center for neurological diseases using multiple conventional molecular methods, including fluorescence in situ hybridization and array comparative genomic hybridization as well as large-insert whole-genome sequencing to survey multiple classes of genomic variations...
May 30, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28550001/more-than-a-text-message-dismantling-digital-triggers-to-curate-behavior-change-in-patient-centered-health-interventions
#3
Frederick Muench, Amit Baumel
Digital triggers such as text messages, emails, and push alerts are designed to focus an individual on a desired goal by prompting an internal or external reaction at the appropriate time. Triggers therefore have an essential role in engaging individuals with digital interventions delivered outside of traditional health care settings, where other events in daily lives and fluctuating motivation to engage in effortful behavior exist. There is an emerging body of literature examining the use of digital triggers for short-term action and longer-term behavior change...
May 26, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28530766/right-ring-finger-volar-mass-in-a-14-year-old-boy
#4
Mary P Fox, Jack E McKay, Randall D Craver, Nicholas D Pappas
A trigger digit is relatively uncommon in adolescents and often has a different etiology in that age group vs adults. In the pediatric population, trigger digits frequently arise from a variety of underlying anatomic situations, including thickening of the flexor digitorum superficialis or flexor digitorum profundus tendons, an abnormal relationship between the flexor digitorum superficialis and flexor digitorum profundus tendons, a proximal flexor digitorum superficialis decussation, or constriction of the pulleys...
May 20, 2017: Orthopedics
https://www.readbyqxmd.com/read/28529023/clinical-efficacy-of-transrectal-ultrasound-guided-prostate-biopsy-in-men-younger-than-50-years-old-with-an-elevated-prostate-specific-antigen-concentration-4-0%C3%A2-ng-ml
#5
Chin-Heng Lu, Tzu-Ping Lin, She Huei Shen, Yi-Hsiu Huang, Hsiao-Jen Chung, Junne-Yih Kuo, William J S Huang, Howard H H Wu, Yen-Hwa Chang, Alex T L Lin, Kuang-Kuo Chen
BACKGROUND: Prostate cancer (PCa) is not commonly found in men younger than 50 years of age. However, serum prostate-specific antigen (PSA) concentration has been examined more frequently at a younger age in Asia partially due to an increased awareness of prostate cancer. The purpose of our study was to investigate the efficacy and complication of PSA-triggered transrectal ultrasonography-guided prostate (TRUSP) biopsies. We retrospectively reviewed TRUSP biopsies in young men with elevated PSA concentration in Taipei Veterans General Hospital...
May 18, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28524096/itraq-mitoproteome-analysis-reveals-mechanisms-of-programmed-cell-death-in-arabidopsis-thaliana-induced-by-ochratoxin-a
#6
Yan Wang, Xiaoli Peng, Zhuojun Yang, Weiwei Zhao, Wentao Xu, Junran Hao, Weihong Wu, Xiao Li Shen, Yunbo Luo, Kunlun Huang
Ochratoxin A (OTA) is one of the most common and dangerous mycotoxins in the world. Previous work indicated that OTA could elicit spontaneous HR-like lesions formation Arabidopsis thaliana, reactive oxygen species (ROS) play an important role in OTA toxicity, and their major endogenous source is mitochondria. However, there has been no evidence as to whether OTA induces directly PCD in plants until now. In this study, the presence of OTA in Arabidopsisthaliana leaves triggered accelerated respiration, increased production of mitochondrial ROS, the opening of ROS-dependent mitochondrial permeability transition pores and a decrease in mitochondrial membrane potential as well as the release of cytochrome c into the cytosol...
May 18, 2017: Toxins
https://www.readbyqxmd.com/read/28506168/trigger-finger-an-atraumatic-medical-phenomenon
#7
Angelo V Vasiliadis, Iraklis Itsiopoulos
Trigger finger is a mechanical problem with many etiological factors as possible causes, such as diabetes mellitus, carpal tunnel syndrome and repetitive finger movements. Although it can afflict anyone, it is much commoner in middle-aged women than men and the most commonly involved digit is reported to be the thumb. The diagnosis is mainly based on clinical symptoms during examination and first-line treatment is conservative with splinting and corticosteroid injections. Surgical open release is the "gold standard" of trigger finger treatment because it allows more careful inspection of the surgical area and is highly effective with low complication rates...
June 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28506159/progression-from-injection-to-surgery-for-trigger-finger-a-statistical-analysis
#8
Hideyuki Ota, Katsuyuki Iwatsuki, Shigeru Kurimoto, Koji Iida, Hitoshi Hirata
BACKGROUND: The purpose of this study was to identify predictive factors of poor response to intra-flexoral sheath corticosteroid injection, as well as to identify factors associated with patients' decisions to undergo surgical treatment. METHODS: Data from 112 patients who received steroid injection treatment for trigger finger were reviewed retrospectively. Logistic regression was used to assess the prognostic value of factors assumed to affect prognosis (age, sex, underlying disease, history of illness, presence of carpal tunnel syndrome, multiple digit involvement, and pre- and post-operative disability scores)...
June 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28501945/macrophage-polarization-differs-between-apical-granulomas-radicular-cysts-and-dentigerous-cysts
#9
Manuel Weber, Tilo Schlittenbauer, Patrick Moebius, Maike Büttner-Herold, Jutta Ries, Raimund Preidl, Carol-Immanuel Geppert, Friedrich W Neukam, Falk Wehrhan
OBJECTIVES: Apical periodontitis can appear clinically as apical granulomas or radicular cysts. There is evidence that immunologic factors are involved in the pathogenesis of both pathologies. In contrast to radicular cysts, the dentigerous cysts have a developmental origin. Macrophage polarization (M1 vs M2) is a main regulator of tissue homeostasis and differentiation. There are no studies comparing macrophage polarization in apical granulomas, radicular cysts, and dentigerous cysts...
May 13, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28488453/evidence-based-management-of-adult-trigger-digits
#10
R Amirfeyz, R McNinch, A Watts, J Rodrigues, T R C Davis, N Glassey, J Bullock
The aim of this systematic review was to develop an evidence-based guideline to assist clinicians in the treatment of adult trigger digits. There is moderate evidence to suggest that local corticosteroid injection is a safe and effective short-term treatment and it may, therefore, be recommended as an initial treatment for this condition. However, when compared with surgery, there is strong evidence that corticosteroid injection is associated with increased rates of ongoing or recurrent symptoms at 6 months after intervention...
June 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28469529/protected-areas-in-the-world-s-ecoregions-how-well-connected-are-they
#11
Santiago Saura, Lucy Bastin, Luca Battistella, Andrea Mandrici, Grégoire Dubois
Protected areas (PAs) are the main instrument for biodiversity conservation, which has triggered the development of numerous indicators and assessments on their coverage, performance and efficiency. The connectivity of the PA networks at a global scale has however been much less explored; previous studies have either focused on particular regions of the world or have only considered some types of PAs. Here we present, and globally assess, ProtConn, an indicator of PA connectivity that (i) quantifies the percentage of a study region covered by protected connected lands, (ii) can be partitioned in several components depicting different categories of land (unprotected, protected or transboundary) through which movement between protected locations may occur, (iii) is easy to communicate, to compare with PA coverage and to use in the assessment of global targets for PA systems...
May 2017: Ecological Indicators
https://www.readbyqxmd.com/read/28468878/cell-culture-systems-to-study-human-herpesvirus-6a-b-chromosomal-integration
#12
Annie Gravel, Isabelle Dubuc, Nina Wallaschek, Shella Gilbert-Girard, Vanessa Collin, Ruth Hall-Sedlak, Keith R Jerome, Yasuko Mori, Julie Carbonneau, Guy Boivin, Benedikt B Kaufer, Louis Flamand
Human herpesviruses 6A/B (HHV-6A/B) can integrate their viral genomes in the telomeres of human chromosomes. The viral and cellular factors contributing to HHV-6A/B integration remain largely unknown, mostly due to the lack of efficient and reproducible cell culture models to study HHV-6A/B integration. In this study, we characterized the HHV-6A/B integration efficiencies in several human cell lines using two different approaches. First, after a short-term infection (5h) cells were processed to single-cell cloning and analyzed for chromosomally-integrated HHV-6A/B (ciHHV-6A/B)...
May 3, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28454779/congenital-extensor-tendon-dislocation-causing-pseudotriggering-of-the-little-finger
#13
Meriç Çırpar, Bülent Dağlar, Birhan Oktaş
The main complaints in extensor tendon dislocations are pain, swelling, sense of discomfort, snapping and difficulty in writing and forceful flexion. However, congenital extensor tendon subluxations may present with triggering of the fingers due to tendon dislocations. Unnecessary A1 pulley release may be performed for pseudotriggerring with unsuccessful results. Here, we report an unusual case of congenital extensor tendon subluxation of multiple digits with triggering of the left little finger and aim to attract notice to pseudotriggering of the digits due to tendon dislocations...
April 25, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28447017/in-sickness-and-in-health-clinical-research-and-social-media
#14
REVIEW
Saswata Ray
In this "digital age," the model of healthcare is changing rapidly, primarily in the area of communication that is happening among the major stakeholders each minute. Patients, being the central point of the importance of all the work and development, are more empowered than ever with information from various sources, among which social media is leading from the front. This article reviews how social media engages healthcare service providers, service seekers, and regulatory authorities. If the gaps in the current regulations are filled, better healthcare outputs can be triggered...
April 2017: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/28443675/the-effect-of-trigger-finger-injection-site-on-injection-related-pain
#15
Yoseph A Rosenbaum, Nikki Benvenuti, Jingzhen Yang, Michael E Ruff, Hisham M Awan, Julie Balch Samora
BACKGROUND: Stenosing tenosynovitis, or trigger digit, is a common condition for which patients often seek relief. Corticosteroid injections have been shown to provide relief in many cases, and several different approaches for delivering the injection have been described in the literature. We compared patients' perception of pain following each of 3 accepted injection methods, namely, palmar proximal, palmar distal, and webspace approaches. METHODS: We prospectively followed 38 patients with 39 symptomatic digits in this trial, with varying severities of trigger finger as graded by the Patel and Moradia classification...
April 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28436344/inattention-tests-for-delirium
#16
Paul Regal
Voyer and colleagues (2016) report an interesting and important comparison of ten attention/concentration tests for DSM-5 delirium. I have a number of questions and comments as follows: (1) What training did the research assistants have? DSM-5 diagnosis is generally regarded as a decision by medical specialists. When the person has prior dementia, identifying delirium is a high-level medical skill. Behavioral and psychological symptoms of dementia can closely mimic delirium unless the examiner focuses on behavioral triggers and the speed of cognitive decline...
April 24, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28435881/the-memory-remains-understanding-collective-memory-in-the-digital-age
#17
Ruth García-Gavilanes, Anders Mollgaard, Milena Tsvetkova, Taha Yasseri
Recently developed information communication technologies, particularly the Internet, have affected how we, both as individuals and as a society, create, store, and recall information. The Internet also provides us with a great opportunity to study memory using transactional large-scale data in a quantitative framework similar to the practice in natural sciences. We make use of online data by analyzing viewership statistics of Wikipedia articles on aircraft crashes. We study the relation between recent events and past events and particularly focus on understanding memory-triggering patterns...
April 2017: Science Advances
https://www.readbyqxmd.com/read/28435575/outpatient-percutaneous-release-of-trigger-finger-a-cost-effective-and-safe-procedure
#18
Z Marij, Q Aurangzeb, H R Rizwan, R Haroon, M H Pervaiz
INTRODUCTION: Trigger finger is a common cause of pain and disability of the hand. Percutaneous release results in earlier functional recovery and patient satisfaction. This is a rapid and cost-effective method which saves a surgical procedure and results in better functional outcome. MATERIALS AND METHODS: This is a prospective observational study conducted on fifty-two fingers and thumbs in 52 patients treated from 1st July 2014 till 31st December 2014, in the Orthopaedic Section, Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan...
March 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/28403262/combination-of-in-office-chemical-peels-with-a-topical-comprehensive-pigmentation-control-product-in-skin-of-color-subjects-with-facial-hyperpigmentation
#19
Jeanine Downie, Katie Schneider, Lisa Goberdhan, Elizabeth T Makino, Rahul C Mehta
<p>Dyschromia is one of the primary complaints for patients with skin of color. Treatments need to achieve a balance between tolerability and efficacy to address existing hyperpigmentation without causing additional damage that could trigger post-inflammatory hyperpigmentation (PIH). An open-label, single-center study was conducted to assess the efficacy of a novel comprehensive pigmentation control serum (LYT2) combined with a series of three very superficial chemical peels (VP) in skin of color subjects...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28387996/porosity-and-tissue-integration-of-elastic-mesh-implants-evaluated-in-vitro-and-in-vivo
#20
Alexander Ciritsis, Andreas Horbach, Manfred Staat, Christiane K Kuhl, Nils Andreas Kraemer
PURPOSE: In vivo, a loss of mesh porosity triggers scar tissue formation and restricts functionality. The purpose of this study was to evaluate the properties and configuration changes as mesh deformation and mesh shrinkage of a soft mesh implant compared with a conventional stiff mesh implant in vitro and in a porcine model. MATERIAL AND METHODS: Tensile tests and digital image correlation were used to determine the textile porosity for both mesh types in vitro...
April 7, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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