keyword
https://read.qxmd.com/read/38487212/cardiometabolic-improvements-after-metabolic-surgery-and-related-presurgery-factors
#21
JOURNAL ARTICLE
Lei Wang, Michael T O'Brien, Xinmeng Zhang, You Chen, Wayne J English, Brandon Williams, Matthew Spann, Vance Albaugh, Xiao-Ou Shu, Charles R Flynn, Danxia Yu
CONTEXT: Metabolic surgery remains the most effective and durable treatment for severe obesity and related metabolic diseases. OBJECTIVE: We examined cardiometabolic improvements after metabolic surgery and associated presurgery demographic and clinical factors in a large multiracial cohort. METHODS: Included were 7804 patients (20-79 years) undergoing first-time metabolic surgery at Vanderbilt University Medical Center from 1999 to 2022. Pre- and 1-year postsurgery cardiometabolic profiles were extracted from medical records, including body mass index (BMI), blood pressure, blood lipids, glucose, and hemoglobin A1c...
March 12, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38481283/postoperative-complications-and-unanticipated-healthcare-encounters-following-mini-laparotomy-vs-laparoscopic-robotic-assisted-sacrocolpopexy-a-comparative-retrospective-study
#22
JOURNAL ARTICLE
Henry H Chill, Alireza Hadizadeh, Claudia Paya-Ten, Angela Leffelman, Cecilia Chang, Nani P Moss, Roger P Goldberg
BACKGROUND: Pelvic organ prolapse is a debilitating condition impacting lives of millions of women worldwide. Sacrocolpopexy (SCP) is considered an effective and durable surgical technique for treatment of apical prolapse. The aim of this study was to compare short-term outcomes including postoperative complications and unanticipated healthcare encounters between patients who underwent SCP with a mini-laparotomy approach compared to patients treated with laparoscopic and robotic-assisted laparoscopic SCP...
March 13, 2024: BMC Women's Health
https://read.qxmd.com/read/38479980/-it-is-both-necessary-and-possible-to-formalize-the-teaching-of-professional-skills-during-medical-studies-in-france
#23
JOURNAL ARTICLE
T Hanslik, D Roux
No abstract text is available yet for this article.
March 2024: La Revue de Médecine Interne
https://read.qxmd.com/read/38476207/esophageal-squamous-cell-carcinoma-transformed-into-neuroendocrine-carcinoma-after-neoadjuvant-immunochemotherapy-a-case-report
#24
Gaojie Xin, Naicheng Song, Ke Jiang
Immunotherapy provides durable responses for locally advanced esophageal carcinoma clinical therapy in numerous patients. However, the mechanisms of resistance to immunotherapy have not been elucidated. The phenomenon of the histological transformation of non-small cell lung cancer to small cell lung cancer resulting in resistance to immune checkpoint inhibitors (ICIs) has been reported. It remains unclear whether ICIs or chemotherapy could cause a similar transformation from esophageal squamous cell carcinoma (ESCC) to esophageal neuroendocrine carcinoma (ENEC)...
April 2024: Oncology Letters
https://read.qxmd.com/read/38474684/recent-advances-in-antibacterial-coatings-to-combat-orthopedic-implant-associated-infections
#25
REVIEW
Seref Akay, Anan Yaghmur
Implant-associated infections (IAIs) represent a major health burden due to the complex structural features of biofilms and their inherent tolerance to antimicrobial agents and the immune system. Thus, the viable options to eradicate biofilms embedded on medical implants are surgical operations and long-term and repeated antibiotic courses. Recent years have witnessed a growing interest in the development of robust and reliable strategies for prevention and treatment of IAIs. In particular, it seems promising to develop materials with anti-biofouling and antibacterial properties for combating IAIs on implants...
March 6, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38471002/microwave-ablation-of-the-pig-growth-plate-proof-of-concept-for-minimally-invasive-epiphysiodesis
#26
JOURNAL ARTICLE
Samuel O Noonan, Kyle J Miller, Stephanie Goldstein, Ellen Leiferman, James White, Chris Brace, Kenneth J Noonan
BACKGROUND: Different surgical methods for epiphysiodesis of limb length discrepancy (LLD) have been described. Although these methods are variably effective, they are associated with morbidity (pain and limp) and potential complications. Microwave ablation is a less-invasive opportunity to halt growth by selectively destroying the growth plate via thermal energy to treat LLD in children. QUESTIONS/PURPOSES: In this proof-of-concept study using an in vivo pig model, we asked: (1) What is the durability of response 2 to 4 months after microwave ablation of the tibial growth plate as measured by length and angulation of the tibia via a CT scan? (2) Was articular cartilage maintained as measured by standard histologic staining for articular cartilage viability? METHODS: To develop an in vivo protocol for microwave ablation, we placed microwave antennas adjacent to the proximal tibia growth plate in the cadaveric hindlimbs of 18 3-month-old pigs...
March 12, 2024: Clinical Orthopaedics and related Research
https://read.qxmd.com/read/38462731/factors-associated-with-the-maintenance-of-cost-effectiveness-at-5-years-in-adult-spinal-deformity-corrective-surgery
#27
JOURNAL ARTICLE
Peter G Passias, Jamshaid M Mir, Pooja Dave, Justin S Smith, Renaud Lafage, Jeffrey Gum, Breton G Line, Bassel Diebo, Alan H Daniels, David Kojo Hamilton, Thomas J Buell, Justin K Scheer, Robert K Eastlack, Jeffrey P Mullin, Gregory M Mundis, Naobumi Hosogane, Mitsuru Yagi, Andrew J Schoenfeld, Juan S Uribe, Neel Anand, Praveen V Mummaneni, Dean Chou, Eric O Klineberg, Khaled M Kebaish, Stephen J Lewis, Munish C Gupta, Han Jo Kim, Robert A Hart, Lawrence G Lenke, Christopher P Ames, Christopher I Shaffrey, Frank J Schwab, Virginie Lafage, Richard A Hostin, Shay Bess, Douglas C Burton
STUDY DESIGN: Retrospective cohort. OBJECTIVE: To evaluate factors associated with the long-term durability of cost-effectiveness (CE) in ASD patients. BACKGROUND: A substantial increase in costs associated with the surgical treatment for adult spinal deformity (ASD) has given precedence to scrutinize the value and utility it provides. METHODS: We included 327 operative ASD patients with 5-year (5 Y) follow-up. Published methods were used to determine costs based on CMS...
March 11, 2024: Spine
https://read.qxmd.com/read/38461567/evolving-survival-gains-in-patients-with-young-onset-colorectal-cancer-and-synchronous-resectable-liver-metastases
#28
JOURNAL ARTICLE
Harufumi Maki, Antony Haddad, Mateo Lendoire, Timothy E Newhook, Oliver Peacock, Brian K Bednarski, Tsuyoshi Konishi, Jean-Nicolas Vauthey, Y Nancy You
We aimed to evaluate the practice and the associated outcomes of surgical treatment for young-onset colorectal cancer (YOCRC) patients presenting with synchronous liver metastases. The study cohort was divided into two groups according to surgery date: 131 patients in the early era (EE, 1998-2011) and 179 in the contemporary era (CE, 2012-2020). The CE had a higher rate of node-positive primary tumors, higher carcinoembryonic antigen level, and lower rate of RAS/BRAF mutations. The CE had higher rates of reverse or combined resection, multi-drug prehepatectomy chemotherapy, and two-stage hepatectomy...
February 23, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38457827/the-extent-and-growth-of-prior-authorization-in-medicare-advantage
#29
JOURNAL ARTICLE
Hannah T Neprash, John F Mulcahy, Ezra Golberstein
OBJECTIVES: To assess trends in the use of prior authorization requirements among Medicare Advantage (MA) plans. STUDY DESIGN: Descriptive quantitative analysis. METHODS: Data were from the CMS MA benefit and enrollment files for 2009-2019, supplemented with area-level data on demographic and provider market characteristics. For each service category, we calculated the annual share of MA enrollees in plans requiring at least some prior authorization and plotted trends over time...
March 1, 2024: American Journal of Managed Care
https://read.qxmd.com/read/38455743/management-of-long-gap-esophageal-atresia
#30
REVIEW
Annalise B Penikis, Anne M Sescleifer, Shaun M Kunisaki
A uniquely challenging subset of infants diagnosed with esophageal atresia (EA) are those born with long-gap EA (LGEA). The common unifying feature in infants with LGEA is that the proximal and distal segments of the esophagus are too far apart to enable primary anastomosis via a single operation in the newborn period. Although any type of EA can technically result in a long gap, the Gross type A variant occurs in 8% of all EA cases and is most commonly associated with LGEA. In this review, we provide an evidence-based approach to the current challenges and management strategies employed in LGEA...
February 29, 2024: Translational Pediatrics
https://read.qxmd.com/read/38455062/dynamics-of-sars-cov-2-immunity-after-vaccination-and-breakthrough-infection-in-rituximab-treated-rheumatoid-arthritis-patients-a-prospective-cohort-study
#31
JOURNAL ARTICLE
Hassen Kared, Ingrid Jyssum, Amin Alirezaylavasani, Ingrid M Egner, Trung The Tran, Lisa Tietze, Katrine Persgård Lund, Anne Therese Tveter, Sella A Provan, Hilde Ørbo, Espen A Haavardsholm, John Torgils Vaage, Kristin Jørgensen, Silje Watterdal Syversen, Fridtjof Lund-Johansen, Guro Løvik Goll, Ludvig A Munthe
BACKGROUND: SARS-CoV-2 vaccination in rheumatoid arthritis (RA) patients treated with B cell-depleting drugs induced limited seroconversion but robust cellular response. We aimed to document specific T and B cell immunity in response to vaccine booster doses and breakthrough infection (BTI). METHODS: We included 76 RA patients treated with rituximab who received up to four SARS-CoV-2 vaccine doses or three doses plus BTI, in addition to vaccinated healthy donors (HD) and control patients treated with tumor necrosis factor inhibitor (TNFi)...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38455036/comparison-of-endoscopic-healing-and-durability-between-infliximab-originator-and-ct-p13-in-pediatric-patients-with-inflammatory-bowel-disease
#32
JOURNAL ARTICLE
Eun Sil Kim, Sujin Choi, Byung-Ho Choe, Sowon Park, Yeoun Joo Lee, Sang Jun Sohn, Soon Chul Kim, Ki Soo Kang, Kunsong Lee, Jung Ok Shim, Yu Bin Kim, Suk Jin Hong, Yoo Min Lee, Hyun Jin Kim, So Yoon Choi, Ju Young Kim, Yoon Lee, Ji-Sook Park, Jae Young Kim, Dae Yong Yi, Ji Hyuk Lee, Kwang-Hae Choi, Hyo-Jeong Jang, In Sook Jeong, Ben Kang
BACKGROUND AND AIMS: Favourable clinical data were published on the efficacy of CT-P13, the first biosimilar of infliximab (IFX), in pediatric inflammatory bowel disease (IBD); however, few studies have compared the effect on endoscopic healing (EH) and drug retention rate between the IFX originator and CT-P13. Therefore, we aimed to compare EH and the drug retention rate between the IFX originator and CT-P13. METHODS: Children with Crohn's disease (CD) and ulcerative colitis (UC)/IBD-unclassified (IBD-U) at 22 medical centers were enrolled, with a retrospective review conducted at 1-year and last follow-up...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38454351/sling-for-the-sling-a-new-technique-for-long-term-correction-of-severe-congenital-ptosis
#33
JOURNAL ARTICLE
Ahmed N Kotb, Noha M Soliman, Ahmer Raza, Noran A Nour, Hala K Mattout
INTRODUCTION: Severe congenital ptosis poses a complex challenge for oculoplastic surgeons, requiring meticulous surgical intervention to restore eyelid function and improve aesthetic outcomes mainly by using frontalis sling approach. A crucial issue in frontalis sling surgeries is the sustainability of effect. PURPOSE: This retrospective study reports the outcomes of two surgical techniques for treating severe congenital ptosis in the paediatric age group: Silicon rods ptosis sling and a novel technique involving the use of Silicon rods with green braided polyester (Ethibond) sutures to secure the rods in place "sling for the sling"...
March 7, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38446475/recombinant-interferon-alfa-in-bcr-abl-negative-chronic-myeloproliferative-neoplasms
#34
REVIEW
Sandy El Bitar, Murat O Arcasoy
The treatment landscape for BCR/ABL-negative myeloproliferative neoplasms (MPNs), driven by JAK2, CALR, and MPL mutations, has evolved significantly over the last decade. Recent regulatory approvals in polycythemia vera (PV) include the JAK inhibitor ruxolitinib, and more recently, a novel recombinant interferon alfa-2 (IFN-α) therapeutic agent. Many clinical trials have documented the safety and efficacy of IFN-α therapy in PV and essential thrombocythemia, the classical BCR/ABL-negative MPNs. Used off-label for more than 30 years as a cytoreductive agent, IFN-α therapy promotes significant clinical, hematologic, and molecular responses...
March 2024: Clinical Advances in Hematology & Oncology: H&O
https://read.qxmd.com/read/38442083/clinical-outcomes-of-arthroscopic-surgery-in-patients-with-gluteal-muscle-contracture-single-institution-results-from-a-high-volume-cohort
#35
JOURNAL ARTICLE
Jianhai Hu, Jiazhuang Zhu, Zheng Zhou, Xiaoxiang Yang, Min Zhu, Peng Wu
BACKGROUND The aim of this study was to assess clinical outcomes of arthroscopic surgery for gluteal muscle contracture (GMC) with at least 2 years of follow-up in a large sample. MATERIAL AND METHODS A total of 665 patients who underwent arthroscopic release procedure at our institution between March 2014 and December 2018 and met the inclusion criteria were included in this study. All the patients were operated on by the same surgeon and the surgeon released the contracture band from anterior to posterior starting from the anterior edge of the ITB, the contracture band of the gluteus maximus, and vastus medialis tensor...
March 5, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/38439727/merkel-cell-carcinoma-of-unknown-primary-origin
#36
JOURNAL ARTICLE
Helena Francetić, Luka Simetić, Čedna Tomasović Lončarić, Daška Štulhofer Buzina, Romana Čeović
Merkel cell carcinoma (MCC) is a rare and highly aggressive primary cutaneous neuroendocrine carcinoma most often occurring in the elderly. Risk factors include chronic sun exposure and immunosuppression (1). MCC is associated with frequent recurrences and a high metastatic potential and mortality rate (1). It is the second most common cause of skin-cancer-related death after melanoma. At primary diagnosis with an apparent cutaneous tumor, loco-regional metastases are present in up to 30% of patients, and 6-12% have distant metastatic disease (2-3)...
December 2023: Acta Dermatovenerologica Croatica: ADC
https://read.qxmd.com/read/38439611/dental-ceramic-damage-associated-with-incorrect-laboratory-procedures
#37
REVIEW
Magdalena Szawioła-Kirejczyk, Karolina Chmura, Wojciech Ryniewicz
Ceramic is a commonly used material in dentistry for reconstructing missing teeth or their tissues due to its biocompatibility, durability and excellent esthetic properties. Despite these advantages, the ceramic restoration damage remains a significant clinical problem. Its causes can be divided into clinical and laboratory factors. The most known include uneven occlusion, improper preparation, trauma, or parafunctions. This study focuses on characterizing less known laboratory causes of ceramic restoration damage...
March 1, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38435448/durable-response-to-programmed-death-1-directed-antibodies-in-a-hypermutated-triple-negative-breast-cancer-a-case-report
#38
Emilie Platteter, Gerburg Wulf
INTRODUCTION: The advent of immune checkpoint inhibitors marks significant progress in the evolution of cancer treatment. Recent clinical trials have demonstrated the success of immune-oncologic (IO) agents like pembrolizumab (Keytruda™ ) in combination with chemotherapy against triple-negative breast cancer (TNBC) [Ann Oncol. 2017 Jun 1;28(6):1388-1398]. There is less literature investigating pembrolizumab in monotherapy and in cases of rare tumor mutational burden. CASE PRESENTATION: Here, we report the case of a 65-year-old Native American and African American woman with previous incomplete lines of therapy diagnosed with recurrent TNBC and pulmonary metastases...
2024: Case Reports in Oncology
https://read.qxmd.com/read/38433951/dose-escalated-sbrt-for-borderline-and-locally-advanced-pancreatic-cancer-feasibility-safety-and-preliminary-clinical-results-of-a-multicenter-study
#39
JOURNAL ARTICLE
B Salas, L Ferrera-Alayón, A Espinosa-López, A Vera-Rosas, E Salcedo, A Kannemann, A Alayon, R Chicas-Sett, M LLoret, P C Lara
BACKGROUND: Pancreatic Stereotactic Body Radiotherapy (SBRT) allows for the administration of a higher biologically effective doses (BED), that would be essential to achieve durable tumor control. Escalating treatment doses need a very accurate tumor positioning and motion control during radiotherapy.The aim of this study to assess the feasibility and safety of a Simultaneous Integrated Boost (SIB) dose-escalated protocol at 45 Gy, 50 Gy and 55 Gy in 5 consecutive daily fractions, in Border Line Resectable Pancreatic Cancer (BRCP) /Locally Advanced Pancreatic Cancer (LAPC) by means of a standard LINAC platform...
March 2024: Clinical and Translational Radiation Oncology
https://read.qxmd.com/read/38432641/the-effect-of-connective-tissue-graft-compared-to-concentrated-growth-factors-on-buccal-peri-implant-gingival-thickness-a-12-month-randomized-controlled-clinical-trial
#40
JOURNAL ARTICLE
Joul Kassis, Magd Esber Aboud
BACKGROUND: Attached gingival phenotype has a crucial impact on the implant's durability and its future success. PURPOSE: This study aims to measure and compare buccal peri-implant gingival thickness following grafting with connective tissue graft (CTG) and the concentrated growth factor (CGF) graft. STUDY DESIGN, SETTING, SAMPLE: This is a split-mouth designed randomized controlled clinical study in which a total of 20 aged 18 to 55 have bilateral missing teeth in the maxillary premolar region with less than 2 mm of healthy peri-implant gingival thickness...
February 15, 2024: Journal of Oral and Maxillofacial Surgery
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