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MMP peridontal

Núria Cerdà-Costa, Tibisay Guevara, Abdulkarim Y Karim, Miroslaw Ksiazek, Ky-Anh Nguyen, Joan L Arolas, Jan Potempa, F Xavier Gomis-Rüth
Metallopeptidases (MPs) are among virulence factors secreted by pathogenic bacteria at the site of infection. One such pathogen is Tannerella forsythia, a member of the microbial consortium that causes peridontitis, arguably the most prevalent infective chronic inflammatory disease known to mankind. The only reported MP secreted by T. forsythia is karilysin, a 52 kDa multidomain protein comprising a central 18 kDa catalytic domain (CD), termed Kly18, flanked by domains unrelated to any known protein. We analysed the 3D structure of Kly18 in the absence and presence of Mg(2+) or Ca(2+) , which are required for function and stability, and found that it evidences most of the structural features characteristic of the CDs of mammalian matrix metalloproteinases (MMPs)...
January 2011: Molecular Microbiology
Xiao-Qin Zhao, Shu Meng, Ya-Fei Wu, Yu Chen, Song Ge
OBJECTIVE: To investigate the expression of MMP-2 and MMP-3 in periodontal tissues of rat periodontitis model at different stages of inflammation of varied severity. METHODS: The periodontal tissues were immunohistochemically stained by antibody of MMP-2 and MMP-3. RESULTS: MMP-2 and MMP-3 were both strongly positive in gingival epithelia and fibroblasts in periodontal ligament in rat periodontitis model. And chronic periodontitis showed lower expression of MMP-2 and MMP-3 than that of acute gingivitis and acute peridontitis...
June 2006: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
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