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https://www.readbyqxmd.com/read/29349483/surgical-outcomes-of-primary-versus-post-neoadjuvant-chemotherapy-breast-conservation-surgery-a-comparative-study-from-a-developing-country
#1
Gaurav Agarwal, Chaitra Sonthineni, Sabaretnam Mayilvaganan, Anjali Mishra, Punita Lal, Vinita Agrawal
INTRODUCTION: In India and other developing countries, breast conservation surgery (BCS) rates in breast cancer patients are low due to advanced disease at presentation and misconceptions about BCS outcomes. Many patients presenting with large or locally advanced breast cancers (LABC) can be offered post-neoadjuvant chemotherapy (NACT) BCS, safety of which is not as well established as that of primary BCS. This retrospective study compared pathological and surgical outcome parameters in patients undergoing primary and post-NACT BCS...
January 18, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29347883/pulmonary-laser-metastasectomy-by-1318-nm-neodymium-doped-yttrium-aluminum-garnet-laser-a-retrospective-study-about-laser-metastasectomy-of-the-lung
#2
Calogero Porrello, Roberto Gullo, Antonino Vaglica, Gregorio Scerrino, Giuseppe Salamone, Leo Licari, Cristina Raspanti, Eliana Gulotta, Gaspare Gulotta, Gianfranco Cocorullo
BACKGROUND: The lungs are among the first organ affected by remote metastases from many primary tumors. The surgical resection of isolated pulmonary metastases represents an important and effective element of therapy. This is a retrospective study about our entire experience with pulmonary resection for metastatic cancer using 1318-nm neodymium-doped yttrium-aluminum garnet laser. METHOD: In this single-institution study, we retrospectively analyzed a group of 209 patients previously treated for primary malignant solid tumors...
January 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29344681/timing-of-blood-transfusion-and-oncologic-outcomes-in-patients-treated-with-radical-nephroureterectomy-for-upper-tract-urothelial-carcinoma
#3
Aditya Bagrodia, Samuel Kaffenberger, Andrew Winer, Katie Murray, Michael Vacchio, Junting Zheng, Irina Ostrovnaya, Bernard H Bochner, Guido Dalbagni, Eugene K Cha, Jonathan A Coleman
PURPOSE: To evaluate the impact of timing of blood transfusion in patients with upper tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU). METHODS: Outcomes of consecutive patients with UTUC treated with RNU were analyzed. Clinicopathologic factors were compared using Fisher's exact test or the Wilcoxon rank-sum test between patients who received any transfusion and no transfusion, and between patients receiving intraoperative transfusion only and patients receiving no transfusion...
January 17, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29341337/endoscopic-endonasal-approach-for-sinonasal-and-anterior-skull-base-malignancies-in-the-elderly
#4
Davide Lepera, Federico Leone, Luca Volpi, Maurizio Bignami, Apostolos Karligkiotis, Alessia Lambertoni, Andrea Pistochini, Remo Accorona, Piero Nicolai, Paolo Castelnuovo
BACKGROUND: The purpose of this study was to report the outcomes of endoscopic transnasal resection for sinonasal and anterior skull-base cancers in elderly patients. METHODS: A retrospective review was performed. The patients were divided into 2 groups, <70 years old and ≥70 years old and compared by univariate analysis. Prognostic factors were evaluated with a multivariate analysis. Survival rates were also calculated. RESULTS: Two hundred three elderly patients and 397 younger patients were enrolled in this study...
January 17, 2018: Head & Neck
https://www.readbyqxmd.com/read/29341160/genetic-analysis-of-surgical-margins-in-oral-cavity-cancer
#5
S A Liu, C C Wang, R S Jiang, W Y Wang, J C Lin
BACKGROUND: A histological, tumour-free surgical margin does not guarantee recurrence-free survival in patients with cancer. This study investigated the association between microsatellite alteration in tumour-free surgical margins and local recurrence in patients with oral cavity squamous cell carcinoma. METHODS: Patients with histologically confirmed oral cavity squamous cell carcinoma were enrolled in this prospective study. Cancerous specimens, corresponding surgical margins and peripheral blood were obtained...
January 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29341148/outcomes-after-prophylactic-gastrectomy-for-hereditary-diffuse-gastric-cancer
#6
R T van der Kaaij, J P van Kessel, J M van Dieren, P Snaebjornsson, O Balagué, F van Coevorden, L E van der Kolk, K Sikorska, A Cats, J W van Sandick
BACKGROUND: Patients with hereditary diffuse gastric cancer and a CDH1 mutation have a 60-80 per cent lifetime risk of developing diffuse gastric cancer. Total prophylactic gastrectomy eliminates this risk, but is associated with considerable morbidity. The effectiveness (removal of all gastric mucosa) and outcomes of this procedure were evaluated retrospectively. METHODS: All consecutive individuals undergoing a prophylactic gastrectomy for a CDH1 mutation or gastric signet ring cell foci at the authors' institute between 2005 and 2017 were included...
January 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29338088/margins-in-breast-cancer-how-much-is-enough
#7
REVIEW
Melissa Pilewskie, Monica Morrow
The appropriate negative margin width for women undergoing breast-conserving surgery for both ductal carcinoma in situ (DCIS) and invasive carcinoma is controversial. This review examines the available data on the margin status for invasive breast cancer and DCIS, and highlights the similarities and differences in tumor biology and standard treatments that affect the local recurrence (LR) risk and, therefore, the optimal surgical margin. Consensus guidelines support a negative margin, defined as no ink on tumor, for invasive carcinoma treated with breast-conserving therapy...
January 16, 2018: Cancer
https://www.readbyqxmd.com/read/29337774/gadolinium-based-contrast-agent-during-pelvic-mri-contribution-to-patient-management-in-rectal-cancer
#8
Marina J Corines, Stephanie Nougaret, Martin R Weiser, Monika Khan, Marc J Gollub
BACKGROUND: Few publications exist regarding gadolinium-enhanced sequences in rectal MRI. None have evaluated its potential impact on patient management. OBJECTIVE: This study aimed to assess whether gadolinium-enhanced sequences, including dynamic contrast enhancement, change radiologic interpretation and clinical management of rectal cancer. DESIGN: This is a retrospective analysis of 100 rectal MRIs (50 baseline and 50 postneoadjuvant treatment), both without and with gadolinium-enhanced sequences...
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29337773/prognostic-factors-for-locoregional-recurrence-in-neuroendocrine-tumors-of-the-rectum
#9
Erica S Tsang, Yarrow J McConnell, David F Schaeffer, Yaling Yin, Caroline H Speers, Hagen F Kennecke
BACKGROUND: Optimal management of rectal neuroendocrine tumors is not yet well defined. Various pathologic factors, particularly tumor size, have been proposed as prognostic markers. OBJECTIVE: We characterized sequential patients diagnosed with rectal neuroendocrine tumors in a population-based setting to determine whether tumor size and other pathologic markers could be useful in guiding locoregional management. DESIGN: This study is a retrospective analysis of data from the British Columbia provincial cancer registry...
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29337772/salvage-surgery-for-locoregional-failure-in-anal-squamous-cell-carcinoma
#10
Glen R Guerra, Joseph C Kong, Maria-Pia Bernardi, Robert G Ramsay, Wayne A Phillips, Satish K Warrier, A Craig Lynch, Samuel Y Ngan, Alexander G Heriot
BACKGROUND: Anal squamous cell carcinoma is a rare cancer with a high cure rate, making research into the treatment of locoregional failure difficult. OBJECTIVE: The purpose of this study was to examine factors related to local treatment failure and determine the outcomes of patients undergoing local salvage resection. DESIGN: This was a retrospective cohort study. SETTING: This study was conducted at a quaternary referral center...
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29337642/perineural-invasion-in-parotid-gland-malignancies
#11
Phillip Huyett, Umamaheswar Duvvuri, Robert L Ferris, Jonas T Johnson, Barry M Schaitkin, Seungwon Kim
Objectives To investigate the clinical predictors and survival implications of perineural invasion (PNI) in parotid gland malignancies. Study Design Case series with chart review. Setting Tertiary care medical center. Subjects and Methods Patients with parotid gland malignancies treated surgically from 2000 to 2015 were retrospectively identified in the Head and Neck Cancer Registry at a single institution. Data points were extracted from the medical record and original pathology reports. Results In total, 186 patients with parotid gland malignancies were identified with a mean follow-up of 5...
January 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29334791/application-of-fluorescence-guided-surgery-to-subsurface-cancers-requiring-wide-local-excision-literature-review-and-novel-developments-toward-indirect-visualization
#12
Kimberley S Samkoe, Brent D Bates, Jonathan T Elliott, Ethan LaRochelle, Jason R Gunn, Kayla Marra, Joachim Feldwisch, Dipak B Ramkumar, David F Bauer, Keith D Paulsen, Brian W Pogue, Eric R Henderson
The excision of tumors by wide local excision is challenging because the mass must be removed entirely without ever viewing it directly. Positive margin rates in sarcoma resection remain in the range of 20% to 35% and are associated with increased recurrence and decreased survival. Fluorescence-guided surgery (FGS) may improve surgical accuracy and has been utilized in other surgical specialties. ABY-029, an anti-epidermal growth factor receptor Affibody molecule covalently bound to the near-infrared fluorophore IRDye 800CW, is an excellent candidate for future FGS applications in sarcoma resection; however, conventional methods with direct surface tumor visualization are not immediately applicable...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29332100/robot-assisted-radical-prostatectomy-is-more-beneficial-for-prostate-cancer-patients-a-system-review-and-meta-analysis
#13
Yuefeng Du, Qingzhi Long, Bin Guan, Lijun Mu, Juanhua Tian, Yumei Jiang, Xiaojing Bai, Dapeng Wu
BACKGROUND Robot-assisted radical prostatectomy (RARP) is increasingly used worldwide, but comparisons of perioperative, functional, and oncologic outcomes among RARP, laparoscopic radical prostatectomy (LRP), and open radical prostatectomy (ORP) remain inconsistent. MATERIAL AND METHODS Systematic literature searches were conducted using EMBASE, PubMed, the Cochrane Library, CNKI, and Science Direct/Elsevier up to April 2017. A meta-analysis was conducted using Review Manager and Stata software. RESULTS We included 33 studies...
January 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29328775/breast-specimen-processing-and-reporting-with-an-emphasis-on-margin-evaluation
#14
Anthony J Guidi, Joseph A Tworek, Daniel D Mais, Rhona J Souers, Barbara J Blond, Richard W Brown
CONTEXT: The College of American Pathologists (CAP) developed protocols for reporting pathologic characteristics of breast cancer specimens, including margin status. The Society of Surgical Oncology (SSO) and the American Society for Radiation Oncology (ASTRO) published treatment guidelines regarding margins in patients with invasive cancer; and SSO, ASTRO, and the American Society of Clinical Oncology (ASCO) recently published guidelines for patients with ductal carcinoma in situ. OBJECTIVE: - To assess current practices among pathologists with regard to the processing/reporting of breast specimens, assess compliance with CAP cancer protocols, and assess alignment with SSO/ASTRO and SSO/ASTRO/ASCO guidelines...
January 12, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29327784/transoral-robotic-surgery-for-oropharyngeal-carcinoma-surgical-margins-and-oncologic-outcomes
#15
Eric J Moore, Kathryn M Van Abel, Daniel L Price, Christine M Lohse, Kerry D Olsen, Ryan S Jackson, Eliot J Martin
BACKGROUND: This study presents oncologic outcomes after transoral robotic surgery (TORS) ± adjuvant therapy for oropharyngeal squamous cell carcinoma (SCC). METHODS: Three hundred fourteen patients undergoing TORS ± adjuvant therapy for oropharyngeal SCC from May 1, 2007, to May 31, 2015, are analyzed. RESULTS: Median follow-up was 3.3 years (interquartile range [IQR] 1.8-5.3 years; range 1 day to 9.3 years). Estimated locoregional recurrence-free survival, distant metastasis-free survival (DMFS), overall survival (OS), and cancer-specific survival (CSS) rates (95% confidence interval [CI] number still at risk) at 5 years after surgery were 92% (88-95; 92), 90% (86-94; 92), 86% (82-92; 98), and 94% (91-97; 98), respectively...
January 12, 2018: Head & Neck
https://www.readbyqxmd.com/read/29327594/liver-resection-and-surgical-strategies-for-management-of-primary-liver-cancer
#16
Sonia T Orcutt, Daniel A Anaya
Primary liver cancer-including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC)-incidence is increasing and is an important source of cancer-related mortality worldwide. Management of these cancers, even when localized, is challenging due to the association with underlying liver disease and the complex anatomy of the liver. Although for ICC, surgical resection provides the only potential cure, for HCC, the risks and benefits of the multiple curative intent options must be considered to individualize treatment based upon tumor factors, baseline liver function, and the functional status of the patient...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29324542/extramammary-paget-disease-of-the-vulva-a-case-series-examining-treatment-recurrence-and-malignant-transformation
#17
Roni Nitecki, Michelle Davis, Jaclyn C Watkins, Yiru E Wu, Allison F Vitonis, Michael G Muto, Ross S Berkowitz, Neil S Horowitz, Colleen M Feltmate
OBJECTIVES: Extramammary Paget disease (EMPD) of the vulva is a rare lesion with a high recurrence rate ranging from 12% to 61%. The rate of underlying adenocarcinoma varies, but in the largest series was reported at 4%. Given the rarity of the disease there is a paucity of data to optimize treatment. This study aims to describe the management and recurrence patterns in a tertiary care setting and to offer suggestions for management in a modern-day setting. METHODS: Patients with pathologically confirmed EMPD treated from 2000 to 2015 were retrospectively identified using an IRB approved database...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29321645/mri-features-predictive-of-negative-surgical-margins-in-patients-with-her2-overexpressing-breast-cancer-undergoing-breast-conservation
#18
Brittany Z Dashevsky, Jung Hun Oh, Aditya P Apte, Blanca Bernard-Davila, Elizabeth A Morris, Joseph O Deasy, Elizabeth J Sutton
Here we develop a tool to predict resectability of HER2+ breast cancer at breast conservation surgery (BCS) utilizing features identified on preoperative breast MRI. We identified patients with HER2+ breast cancer who obtained pre-operative breast MRI and underwent BCS between 2002-2013. From the contoured tumor on pre-operative MRI, shape, histogram, and co-occurrence and size zone matrix texture features were extracted. In univariate analysis, Spearman's correlation coefficient (Rs) was used to assess the correlation between each image feature and an endpoint (surgical re-excision)...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316106/robotic-assisted-radical-cystectomy-with-intracorporeal-urinary-diversion-versus-open-early-australian-experience
#19
Ken Chow, Homayoun Zargar, Niall M Corcoran, Anthony J Costello, Justin S Peters, Philip Dundee
BACKGROUND: The aim of this study was to describe our initial Australian single surgeon experience with robotic-assisted radical cystectomy (RARC) and intracorporeal urinary diversion (ICUD) and to compare the outcomes with open radical cystectomy (ORC). METHODS: Between January 2014 and June 2016, consecutive patients diagnosed with muscle invasive and high-risk non-muscle invasive bladder cancer undergoing radical cystectomy were included. Treatment modalities included either RARC with ICUD or ORC...
January 8, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29313973/mouse-model-of-post-surgical-primary-tumor-recurrence-and-regional-lymph-node-metastasis-progression-in-hpv-related-head-and-neck-cancer
#20
Maxime Mermod, Agnès Hiou-Feige, Esther Bovay, Vincent Roh, Jana Sponarova, Massimo Bongiovanni, Daniel W Vermeer, John H Lee, Tatiana V Petrova, Jean-Paul Rivals, Yan Monnier, Genrich V Tolstonog, Christian Simon
HPV-positive head and neck squamous cell carcinoma (HNSCC) is increasingly frequent. Management is particularly debated in the case of post-surgical high-risk features, i.e., positive surgical margins and extracapsular spread (ECS). In this increasingly complex emerging framework of HNSCC treatment, representative pre-clinical models are needed to support future clinical trials and advances in personalized medicine. Here, we present an immunocompetent mouse model based on the implantation of mouse tonsil epithelial HPV16-E6/E7-expressing cancer cells into the submental region of the floor-of-the-mouth...
January 4, 2018: International Journal of Cancer. Journal International du Cancer
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