keyword
MENU ▼
Read by QxMD icon Read
search

Onco

keyword
https://www.readbyqxmd.com/read/28632300/chemo-bacterial-synthesis-of-a-sialyl-tn-cyclopeptide-vaccine-candidate
#1
Emeline Richard, C Pifferi, M Fiore, Eric Samain, Audrey Le Gouellec, Sébastien Fort, Olivier Renaudet, Bernard Priem
A conjugatable form of the tumour-associated carbohydrate antigen sialyl-Tn (Neu5Ac-alfa-2,6-GalNAc) was efficiently produced in Escherichia coli. Metabolically engineered E. coli strains overexpressing the 6-sialyl-transferase gene of Photobacterium sp. and CMP-Neu5Ac synthetase genes of Neisseria meningitidis were cultivated at high density in presence of GalNAc-alfa-propargyl as the exogeneous acceptor. The target disaccharides, which were produced on the scale of several hundred milligrams, were then conjugated using CuAAC click chemistry to a fully synthetic and immunogenic scaffold with the aim to create a candidate anticancer vaccine...
June 20, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28627778/engineering-cho-cells-with-an-oncogenic-kit-improves-cells-growth-resilience-to-stress-and-productivity
#2
Mohamed Mahameed, Boaz Tirosh
An optimized biomanufacturing process in mammalian cells is contingent on the ability of the producing cells to reach high viable cell densities. In addition, at the peak of growth, cells need to continue producing the biological entity at a consistent quality. Thus, engineering cells with robust growth performance and resilience to variable stress conditions is highly desirable. The tyrosine kinase receptor, KIT, plays a key role in cell differentiation and the survival of several immune cell types. Its oncogenic mutant, D816V, endows cells with high proliferation capacity and resistance to kinase inhibitors...
June 19, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28608763/identifying-clinical-risk-in-low-grade-gliomas-and-appropriate-treatment-strategies-with-special-emphasis-on-the-role-of-surgery
#3
Sébastien Boissonneau, Hugues Duffau
Diffuse low-grade glioma (DLGG) is a chronic tumoral disease that ineluctably grows, migrates along white matter pathways, and progresses to a higher grade of malignancy. Areas covered: To determine the best individualized treatment attitude for each DLGG patient, and to redefine it over the years, i.e. to optimize the "onco-functional balance" of serial and multimodal therapies, the understanding of the natural history of this chronic disease is crucial but not sufficient. A paradigmatic shift is to tailor the individual management according to the dynamic relationships between DLGG course and neural remodeling...
June 13, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28608137/red-blood-cell-transfusion-in-the-resuscitation-of-septic-patients-with-hematological-malignancies
#4
Adrien Mirouse, Matthieu Resche-Rigon, Virginie Lemiale, Djamel Mokart, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne Renault, Anne-Pascale Meert, Dominique Benoit, Rebecca Hamidfar, Mercé Jourdain, Michaël Darmon, Elie Azoulay, Frédéric Pène
BACKGROUND: Indications for red blood cell (RBC) transfusion in septic acute circulatory failure remain unclear. We addressed the practices and the prognostic impact of RBC transfusion in the early resuscitation of severe sepsis and septic shock in patients with hematological malignancies. METHODS: We performed a retrospective analysis of a prospectively collected database of patients with hematological malignancies who required intensive care unit (ICU) admission in 2010-2011...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28602709/factors-associated-with-the-use-of-potentially-inappropriate-medications-by-older-adults-with-cancer
#5
Cristiane Moreira Reis, Andrezza Gouvêa Dos Santos, Paula de Jesus Souza, Adriano Max Moreira Reis
OBJECTIVES: To determine the frequency and the factors associated with the use of potentially inappropriate medications (PIMs) by older adults with cancer at an onco-haematology ambulatory clinic of a teaching hospital in Brazil. MATERIAL AND METHODS: Patients aged 60years or older (n=160) subjected to parenteral antineoplastic chemotherapy from May to December 2015 and treated with one or more medications in the ambulatory clinic were interviewed. Data on medications, comorbidities, oncological diagnosis, and functional status were recorded...
June 8, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28598990/neurological-failure-in-icu-patients-with-hematological-malignancies-a-prospective-cohort-study
#6
Chiara Marzorati, Djamel Mokart, Frederic Pène, Virginie Lemiale, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Dominique Benoit, Giuseppe Citerio, Elie Azoulay, Stephane Legriel
BACKGROUND: Epidemiological studies of neurological complications in patients with hematological malignancies are scant. The objective of the study was to identify determinants of survival in patients with hematological malignancy and neurological failure. METHODS: Post hoc analysis of a prospective study of adults with hematological malignancies admitted for any reason to one of 17 university or university-affiliated participating ICUs in France and Belgium (2010-2012)...
2017: PloS One
https://www.readbyqxmd.com/read/28559989/microrna-142-5p-promotes-cell-growth-and-migration-in-renal-cell-carcinoma-by-targeting-btg3
#7
Lingqi Liu, Shuchao Liu, Qixin Duan, Liang Chen, Tianpeng Wu, Huijun Qian, Sixing Yang, Dianqi Xin, Zhisong He, Yinglu Guo
PURPOSE: Some microRNA (miRNA) levels have been found to be dysregulated in cancer patients, suggesting the potential usefulness of miRNAs in cancer therapies. The purpose of this study was to investigate the expression of miR-142-5p in human renal cell carcinoma (RCC) and its potential role in tumor growth and metastasis. METHODS: The expression level of miR-142-5p in human RCC tissue and cell lines was determined by quantitative reverse transcription polymerase chain reaction analysis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28557833/lymphovascular-space-invasion-for-endometrial-cancer-undertreatment-and-overtreatment-risks-a-survey-of-the-spanish-gynecologic-oncology-group
#8
Mikel Gorostidi Pulgar, Begoña Diaz de la Noval, Blanca Gil-Ibañez, Victor Lago Leal, Ibon Jaunarena Marin, Pablo Padilla Iserte
OBJECTIVE: The purpose of this study is to asses the impact of lymphovascular space invasion (LVSI) present in early-stage endometrial cancer, regarding its therapeutic management and prognosis knowledge, based on a survey among Spanish oncologic gynecologist. METHODS/MATERIALS: Between October and November 2014, the Young Spanish Onco-gynecologist Group carried out a survey to perform a cross-sectional study about the management of LVSI. All active members in the oncology field of the Spanish Society of Gynecology and Obstetrics were invited to participate in the survey...
May 26, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28556798/loss-of-bax-by-mir-365-promotes-cutaneous-squamous-cell-carcinoma-progression-by-suppressing-apoptosis
#9
Liang Zhou, Ruirui Gao, Yinghui Wang, Meijuan Zhou, Zhenhua Ding
Pro-apoptotic BCL2 associated X (BAX) is traditionally thought to be regulated by anti-apoptotic BCL-2 family members, like BCL2-like 1 (BCL-XL), at the protein level. However, the posttranscriptional regulation of BAX is under explored. In this study, we identified BAX as the novel downstream target of miR-365, which is supported by gain- and loss-of-function studies of onco-miR-365. Loss of BAX by either RNA interference or highly-expressed miR-365 in cells of cutaneous squamous cell carcinoma (CSCC) enhanced the tumor resistance against apoptosis, while repressing cell proliferation, migration, and invasiveness...
May 30, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28556426/retrospective-study-on-the-incidence-and-outcome-of-proven-and-probable-invasive-fungal-infections-in-high-risk-pediatric-onco-hematological-patients
#10
Simone Cesaro, Gloria Tridello, Elio Castagnola, Elisabetta Calore, Francesca Carraro, Ilaria Mariotti, Antonella Colombini, Katia Perruccio, Nunzia Decembrino, Giovanna Russo, Natalia Maximova, Valentina Baretta, Désirée Caselli
BACKGROUND: invasive fungal infection (IFI) is a cause of morbidity, mortality and increased health costs in children undergoing chemotherapy or hematopoietic stem cell transplant (HSCT). METHODS: multi-center, retrospective study to assess the incidence, outcome of proven and probable IFI (PP-IFI) in children treated for acute leukemia, non-Hodgkin lymphoma or who underwent HSCT from 2006 to 2012. RESULTS: Over the 7-year period, 127 PP-IFI were diagnosed in 123 patients, median age of 9...
May 27, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28554917/optimisation-and-validation-of-a-remote-monitoring-system-onco-trec-for-home-based-management-of-oral-anticancer-therapies-an-italian-multicentre-feasibility-study
#11
Alessandro Passardi, Mimma Rizzo, Francesca Maines, Carlo Tondini, Alberto Zambelli, Roberto Vespignani, Daniele Andreis, Ilaria Massa, Marco Dianti, Stefano Forti, Enrico Maria Piras, Claudio Eccher
INTRODUCTION: Despite the growing number of oral agents available for cancer treatment, their efficacy may be reduced due to the lack of adherence, inappropriate adverse event self-management and arbitrary dose adjustment. The management of anticancer therapies could exponentially benefit from the introduction of mobile health technologies in a highly integrated electronic oncology system. METHODS AND ANALYSIS: We plan to customise and fine-tune an existing monitoring TreC platform used in different chronic diseases in the oncology setting...
May 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28554666/human-cytomegalovirus-mediated-immunomodulation-effects-on-glioblastoma-progression
#12
REVIEW
Haidn Foster, Ilya V Ulasov, Charles S Cobbs
The presence of human cytomegalovirus (HCMV) and glioblastoma multiforme (GBM), first established in 2002, has developed into an area of considerable interest and controversy. Numerous studies have found evidence of possible HCMV infection of GBM tumor cells as well as myriad onco- and immunomodulatory properties exhibited by HCMV antigens and transcripts, while recent reports have failed to detect HCMV particles in GBM and question the virus' role in tumor progression. This review highlights the known immunomodulatory properties of HCMV, independent of GBM infection status, that help drive the virus from peripheral blood into the vital tissues and subsequently dampen local immune response, assisting GBM tumors in evading immune surveillance and contributing to the disease's poor prognosis...
May 26, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28546132/identification-of-direct-target-genes-of-mir-7-mir-9-mir-96-and-mir-182-in-the-human-breast-cancer-cell-lines-mcf-7-and-mda-mb-231
#13
Hamidreza Moazzeni, Ali Najafi, Marzieh Khani
Some microRNAs have carcinogenic or tumor suppressive effects in breast cancer, which is the most common cancer in women worldwide. MiR-7 and miR-9 are tumor suppressor microRNAs, which induce apoptosis and inhibit proliferation in breast cancer cells. Moreover, miR-96 and miR-182 are onco-microRNAs that increase proliferation, migration, and tumorigenesis in breast cancer cells. This study aimed to identify the direct target genes of these four microRNAs in the human breast cancer cell lines MCF-7 and MDA-MB-231...
May 22, 2017: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/28536393/the-strategies-to-homogenize-pet-ct-metrics-the-case-of-onco-haematological-clinical-trials
#14
REVIEW
Stephane Chauvie, Fabrizio Bergesio
Positron emission tomography (PET) has been a widely used tool in oncology for staging lymphomas for a long time. Recently, several large clinical trials demonstrated its utility in therapy management during treatment, paving the way to personalized medicine. In doing so, the traditional way of reporting PET based on the extent of disease has been complemented by a discrete scale that takes in account tumour metabolism. However, due to several technical, physical and biological limitations in the use of PET uptake as a biomarker, stringent rules have been used in clinical trials to reduce the errors in its evaluation...
November 15, 2016: Biomedicines
https://www.readbyqxmd.com/read/28522182/hodotopy-neuroplasticity-and-diffuse-gliomas
#15
H Duffau
BACKGROUND AND PURPOSE: The historical approach in neurooncology is used to mainly investigate the tumor, with very few considerations regarding the brain itself. Nonetheless, to select the best personalized therapeutic management for each patient with a diffuse glioma, i.e. to optimize the "onco-functional balance", the brain reaction induced by glioma growth and migration should be studied. Indeed, due to strong interactions between the glioma and the brain, cerebral adaptive phenomena often occur in order to maintain neurological and cognitive functions, as well as to compensate glioma spreading...
May 15, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28511670/onco-testicular-sperm-extraction-onco-tese-for-bilateral-testicular-tumors-two-case-reports
#16
Sohgo Tsutsumi, Takashi Kawahara, Teppei Takeshima, Sawako Chiba, Koichi Uemura, Masako Otani, Kota Shimokihara, Yutaro Hayashi, Taku Mochizuki, Daiji Takamoto, Yusuke Hattori, Jun-Ichi Teranishi, Yasuhide Miyoshi, Masahiro Yao, Yoshiaki Inayama, Yasushi Yumura, Hiroji Uemura
BACKGROUND: Most patients with testicular cancer are infertile; thus, the preservation of the sperm after surgery is an important factor to consider. We report two cases of bilateral testicular cancer in patients who underwent bilateral higher orchiectomy and simultaneous testicular sperm extraction. CASE PRESENTATION: Two Asian-Japanese men were referred to our hospital with bilateral testicular tumors. Both of the patients were preoperatively diagnosed with azoospermia and requested testicular sperm extraction at the time of higher orchiectomy...
May 17, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28505193/the-drosophila-orthologue-of-the-int6-onco-protein-regulates-mitotic-microtubule-growth-and-kinetochore-structure
#17
Fioranna Renda, Claudia Pellacani, Anton Strunov, Elisabetta Bucciarelli, Valeria Naim, Giuseppe Bosso, Elena Kiseleva, Silvia Bonaccorsi, David J Sharp, Alexey Khodjakov, Maurizio Gatti, Maria Patrizia Somma
INT6/eIF3e is a highly conserved component of the translation initiation complex that interacts with both the 26S proteasome and the COP9 signalosome, two complexes implicated in ubiquitin-mediated protein degradation. The INT6 gene was originally identified as the insertion site of the mouse mammary tumor virus (MMTV), and later shown to be involved in human tumorigenesis. Here we show that depletion of the Drosophila orthologue of INT6 (Int6) results in short mitotic spindles and deformed centromeres and kinetochores with low intra-kinetochore distance...
May 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28495035/selection-of-bacillus-thuringiensis-strains-toxic-to-cotton-boll-weevil-anthonomus-grandis-coleoptera-curculionidae-larvae
#18
Melisa P Pérez, Diego H Sauka, María I Onco, Marcelo F Berretta, Graciela B Benintende
Preliminary bioassays with whole cultures (WC) of 124 Bacillus thuringiensis strains were performed with neonate larvae of Anthonomus grandis, a major cotton pest in Argentina and other regions of the Americas. Three exotic and four native strains were selected for causing more than 50% mortality. All of them were β-exotoxin producers. The native strains shared similar morphology of parasporal crystals, similar protein pattern and identical insecticidal gene profiles. These features resembled Lepidoptera-toxic strains...
May 8, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28488971/quality-assessment-and-transfusion-efficacy-of-buffy-coat-derived-platelet-concentrates-washed-with-platelet-additive-solution
#19
Hermógenes Fernández-Muñoz, Cristina Castilla-Llorente, Eva M Plaza, Cristina Martínez-Millán, Inmaculada Heras, Pastora Iniesta, María L Amigo, Francisca Ferrer-Marin, María J Candela, María L Lozano, Vicente Vicente, José Rivera
BACKGROUND: Transfusion of washed platelet concentrates (W-PC) is recommended for some patients, such as those who have had previous severe allergic transfusion reactions. However, we still lack a standardised method for preparing these products. Here, we assessed the effect of a manual washing procedure on in vitro platelet quality and on the transfusion efficacy of W-PCs. MATERIALS AND METHODS: Buffy coat-derived W-PC in Composol solution were prepared by onestep centrifugation...
April 13, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28486238/dermoscopy-of-malignant-skin-tumours-what-s-new
#20
Teresa Russo, Vincenzo Piccolo, Aimilios Lallas, Jason Jacomel, Elvira Moscarella, Roberto Alfano, Giuseppe Argenziano
Dermoscopy represents a new and effective tool that assists dermatologists in improving the accuracy of clinical diagnosis in onco-dermatology. The aim of this article is to provide an overview of the latest and important dermoscopic progress and observations in this ever-evolving field of dermatology.
May 10, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
keyword
keyword
39735
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"