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https://www.readbyqxmd.com/read/28928024/two-novel-challenges-in-platelets-potential-cause-of-transfusion-failures-in-onco-hematologic-patients-versus-success-in-eye-regenerative-medicine
#1
EDITORIAL
Jerard Seghatchian
No abstract text is available yet for this article.
August 26, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28923920/microrna-dysregulation-to-identify-therapeutic-target-combinations-for-chronic-lymphocytic-leukemia
#2
Laura Z Rassenti, Veronica Balatti, Emanuela M Ghia, Alexey Palamarchuk, Luisa Tomasello, Paolo Fadda, Yuri Pekarsky, George F Widhopf, Thomas J Kipps, Carlo M Croce
Loss of miR-15/16 is the most common genetic lesion in chronic lymphocytic leukemia (CLL), promoting overexpression of BCL2, which factors in leukemia pathogenesis. Indeed, an inhibitor of Bcl2, venetoclcax, is highly active in the treatment of patients with CLL. However, single-agent venetoclcax fails to eradicate minimal residual disease in most patients. Accordingly, we were interested in other genes that may be regulated by miR-15/16, which may target other drivers in CLL. We found that miR-15/16 targets ROR1, which encodes an onco-embryonic surface protein expressed on the CLL cells of over 90% of patients, but not on virtually all normal postpartum tissues...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28923911/how-ribosomes-translate-cancer
#3
REVIEW
Sergey O Sulima, Isabel J F Hofman, Kim De Keersmaecker, Jonathan D Dinman
A wealth of novel findings, including congenital ribosomal mutations in ribosomopathies and somatic ribosomal mutations in various cancers, have significantly increased our understanding of the relevance of ribosomes in oncogenesis. Here, we explore the growing list of mechanisms by which the ribosome is involved in carcinogenesis-from the hijacking of ribosomes by oncogenic factors and dysregulated translational control, to the effects of mutations in ribosomal components on cellular metabolism. Of clinical importance, the recent success of RNA polymerase inhibitors highlights the dependence on "onco-ribosomes" as an Achilles' heel of cancer cells and a promising target for further therapeutic intervention...
September 18, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28902356/mir-378-functions-as-an-onco-mirna-by-targeting-the-st7l-wnt-%C3%AE-catenin-pathway-in-cervical-cancer
#4
Shengjie Li, Fengxia Yang, Meiyan Wang, Wenjun Cao, Zhen Yang
Upregulation or downregulation of microRNAs (miRNAs) has been identified in human cervical cancer (CC). However, the character and function of miR-378 in CC remains unknown. In the present study, the authors demonstrated that miR-378 was upregulated in CC used the reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) assay, and promoted cell proliferation by accelerating the progress of cell cycle and repressing cell apoptosis in CC cells. The predicted target genes of miR-378 were determined by enhanced green fluorescent protein (EGFP) reporter assays, RT-qPCR assay and western blot analysis...
August 30, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28901791/determinants-of-1-year-survival-in-critically-ill-acute-leukemia-patients-a-grrr-oh-study
#5
Márcio Tavares, Virginie Lemiale, Djamel Mokart, Frédéric Pène, Etienne Lengliné, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne-Pascale Meert, Dominique Benoit, Michael Darmon, Elie Azoulay
Acute leukemia (AL) is the most common hematological malignancy requiring intensive care unit (ICU) management. Data on long-term survival are limited. This is a post hoc analysis of the prospective multicenter data from France and Belgium: A Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique [A Research Group on Acute Respiratory Failure in Onco-Hematological Patients (French)] Study, to identify determinants of 1-year survival in critically ill AL patients. A total of 278 patients were admitted in the 17 participating ICUs...
September 13, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28862319/breakthroughs-in-modern-cancer-therapy-and-elusive-cardiotoxicity-critical-research-practice-gaps-challenges-and-insights
#6
REVIEW
Ping-Pin Zheng, Jin Li, Johan M Kros
To date, five cancer treatment modalities have been defined. The three traditional modalities of cancer treatment are surgery, radiotherapy, and conventional chemotherapy, and the two modern modalities include molecularly targeted therapy (the fourth modality) and immunotherapy (the fifth modality). The cardiotoxicity associated with conventional chemotherapy and radiotherapy is well known. Similar adverse cardiac events are resurging with the fourth modality. Aside from the conventional and newer targeted agents, even the most newly developed, immune-based therapeutic modalities of anticancer treatment (the fifth modality), e...
September 1, 2017: Medicinal Research Reviews
https://www.readbyqxmd.com/read/28861152/microrna-138-attenuates-epithelial-to-mesenchymal-transition-by-targeting-sox4-in-clear-cell-renal-cell-carcinoma
#7
Feng Liu, Linfeng Wu, Anping Wang, Yajun Xu, Xiaodong Luo, Xing Liu, Yi Hua, Deying Zhang, Shengde Wu, Tao Lin, Dawei He, Guanghui Wei, Shanwen Chen
MicroRNAs (miRNAs) are small, non-coding RNAs which can serve as oncogenes or tumor suppressor genes in human cancers. Herein, the transcriptomic differences of miRNAs in ccRCC were globally assessed using publicly available microarray dataset (GSE71302) from Gene Expression Omnibus (GEO) and we identified miR-138 as a potential onco-suppressive miRNA. We further found that the expression of miR-138 was dramatically decreased in ccRCC cell lines and clinical ccRCC tissue samples, and the low miR-138 expression was closely correlated with tumor progression and prognosis in ccRCC patients...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28858535/implementation-of-surgeon-initiated-gene-expression-profile-testing-onco-type-dx-among-patients-with-early-stage-breast-cancer-to-reduce-delays-in-chemotherapy-initiation
#8
Katya Losk, Rachel A Freedman, Nancy U Lin, Mehra Golshan, Stephen M Pochebit, Susan C Lester, Kelsey Natsuhara, Kristen Camuso, Tari R King, Craig A Bunnell
PURPOSE: Delays to adjuvant chemotherapy initiation in breast cancer may adversely affect clinical outcomes and patient satisfaction. We previously identified an association between genomic testing (Onco type DX) and delayed chemotherapy initiation. We sought to reduce the interval between surgery and adjuvant chemotherapy initiation by developing standardized criteria and workflows for Onco type DX testing. METHODS: Criteria for surgeon-initiated reflex Onco type DX testing, workflows for communication between surgeons and medical oncologists, and a streamlined process for receiving and processing Onco type DX requests in pathology were established by multidisciplinary consensus...
September 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28845130/anaesthetic-challenges-in-cancer-patients-current-therapies-and-pain-management
#9
Jūratė Gudaitytė, Dominykas Dvylys, Indrė Šimeliūnaitė
THE OBJECTIVE: The aim is to present the major effects of cancer treatment (chemotherapy, radiotherapy, surgery) that the anaesthesiologist should consider preoperatively, and to review techniques of the analgesic management of the disease. MATERIALS AND METHODS: To summarize the major challenges that cancer patients present for the anaesthesiologists, a literature review was conducted. Articles presenting evidence or reviewing the possible effects of anaesthetics on cancer cells were also included...
2017: Acta medica Lituanica
https://www.readbyqxmd.com/read/28838770/a-modified-nasolabial-flap-for-reconstruction-of-transfixing-alar-wing-defects
#10
J Bouhassira, B Hersant, W Noel, P Aguilar, J Niddam, J-P Meningaud
Reconstruction of an entire alar wing is a frequently encountered reconstructive challenge in onco-dermatologic surgery. The aim of this technical note was to describe a surgical technique total for reconstruction of the alar wing, with a modified nasolabial flap with an inferior pedicle associated with a cartilaginous graft. This rapid procedure seems to be a well alternative for elderly people and patients who do not want a forehead flap. The aesthetic and functional outcomes of the donor and recipient sites were satisfactory...
August 22, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28837809/decomposing-oncogenic-transcriptional-signatures-to-generate-maps-of-divergent-cellular-states
#11
Jong Wook Kim, Omar O Abudayyeh, Huwate Yeerna, Chen-Hsiang Yeang, Michelle Stewart, Russell W Jenkins, Shunsuke Kitajima, David J Konieczkowski, Kate Medetgul-Ernar, Taylor Cavazos, Clarence Mah, Stephanie Ting, Eliezer M Van Allen, Ofir Cohen, John Mcdermott, Emily Damato, Andrew J Aguirre, Jonathan Liang, Arthur Liberzon, Gabriella Alexe, John Doench, Mahmoud Ghandi, Francisca Vazquez, Barbara A Weir, Aviad Tsherniak, Aravind Subramanian, Karina Meneses-Cime, Jason Park, Paul Clemons, Levi A Garraway, David Thomas, Jesse S Boehm, David A Barbie, William C Hahn, Jill P Mesirov, Pablo Tamayo
The systematic sequencing of the cancer genome has led to the identification of numerous genetic alterations in cancer. However, a deeper understanding of the functional consequences of these alterations is necessary to guide appropriate therapeutic strategies. Here, we describe Onco-GPS (OncoGenic Positioning System), a data-driven analysis framework to organize individual tumor samples with shared oncogenic alterations onto a reference map defined by their underlying cellular states. We applied the methodology to the RAS pathway and identified nine distinct components that reflect transcriptional activities downstream of RAS and defined several functional states associated with patterns of transcriptional component activation that associates with genomic hallmarks and response to genetic and pharmacological perturbations...
August 23, 2017: Cell Systems
https://www.readbyqxmd.com/read/28837697/herpesviruses-shape-tumour-microenvironment-through-exosomal-transfer-of-viral-micrornas
#12
Ohad Yogev, Stephen Henderson, Matthew John Hayes, Sara Sofia Marelli, Yifat Ofir-Birin, Neta Regev-Rudzki, Javier Herrero, Tariq Enver
Metabolic changes within the cell and its niche affect cell fate and are involved in many diseases and disorders including cancer and viral infections. Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS). KSHV latently infected cells express only a subset of viral genes, mainly located within the latency-associated region, among them 12 microRNAs. Notably, these miRNAs are responsible for inducing the Warburg effect in infected cells. Here we identify a novel mechanism enabling KSHV to manipulate the metabolic nature of the tumour microenvironment...
August 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28817181/introduction-of-hsa-mir-103a-and-hsa-mir-1827-and-hsa-mir-137-as-new-regulators-of-wnt-signaling-pathway-and-their-relation-to-colorectal-carcinoma
#13
Ali Fasihi, Bahram M Soltani, Amir Atashi, Shirzad Nasiri
Wnt signaling is hyper-activated in most of human cancers including colorectal carcinoma (CRC). Therefore, the introduction of new regulators for Wnt pathway possesses promising diagnostic and therapeutic applications in cancer medicine. Bioinformatics analysis introduced hsa-miR-103a, hsa-miR-1827, and hsa-miR-137 as potential regulators of Wnt signaling pathway. Here, we intended to examine the effect of these human miRNAs on Wnt signaling pathway components, on the cell cycle progression in CRC originated cell lines and their expression in CRC tissues...
August 17, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28796812/toxicological-and-bio-distribution-profile-of-a-gm-csf-expressing-double-targeted-chimeric-oncolytic-adenovirus-oncos-102-support-for-clinical-studies-on-advanced-cancer-treatment
#14
Lukasz Kuryk, Lotta Vassilev, Tuuli Ranki, Akseli Hemminki, Aila Karioja-Kallio, Onerva Levälampi, Antti Vuolanto, Vincenzo Cerullo, Sari Pesonen
The purpose of this work was to carry out preclinical toxicity and bio-distribution studies required for regulatory approval of a clinical trial application for Phase I clinical studies of ONCOS-102 (Ad5/3-D24-GM-CSF) for therapy of advanced cancers (NCT01598129). The study design, route of administration and dosage differs from the clinical protocol and in more detail, investigate bio-distribution and toxicological profile of ONCOS-102 treatment in animal model. The study was carried out in 300 hamsters divided into nine test groups-three bio-distribution groups and six groups for analysis of toxicity...
2017: PloS One
https://www.readbyqxmd.com/read/28781949/mir-203a-3p-1-targets-il-24-to-modulate-hepatocellular-carcinoma-cell-growth-and-metastasis
#15
Wei Huo, Min Du, Xinyan Pan, Xiaomin Zhu, Yu Gao, Zhimin Li
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death. Cytokines, including interleukin 24 (IL-24), play an important role in HCC. IL-24 inhibits HCC metastasis but the molecular mechanism by which this occurs is still unknown. MicroRNAs (miRNAs) are regulators of cancers including hepatocellular carcinoma (HCC). However, the role that miRNAs play in the regulation of IL-24 in HCC is unclear. The aim of this study was to investigate the effects of regulation of IL-24 by miR-203a-3p...
August 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28780419/down-regulation-of-microrna-224-inhibites-growth-and-epithelial-to-mesenchymal-transition-phenotype-via-modulating-sufu-expression-in-bladder-cancer-cells
#16
Xiaobo Miao, Hai Gao, Shiyong Liu, Meijuan Chen, Wenwen Xu, Xuguang Ling, Xubin Deng, Chuangzhou Rao
Aberrant expression of miR-224 is usually found in cancer studies; however, the role of miR-224 has seldom been reported in bladder cancer (BC). We explored miR-224's function and the underlying mechanism in BC. It was found that miR-224 expression was significantly up-regulated in BC tissues and cell lines. Knockdown of miR-224 decreased BC cell growth and invasion both in vitro and in vivo. We identified the SUFU protein as a downstream target of miR-224 by using luciferase and western blot assays. We proposed that miR-224 promoted BC cell growth and invasion via sustaining the activity of Hedgehog pathway, which was negatively regulated by SUFU...
August 2, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28771442/oncomir-17-5p-alarm-signal-in-cancer
#17
REVIEW
Madhusudhan Reddy Bobbili, Robert M Mader, Johannes Grillari, Hanna Dellago
Soon after microRNAs entered the stage as novel regulators of gene expression, they were found to regulate -and to be regulated by- the development, progression and aggressiveness of virtually all human types of cancer. Therefore, miRNAs in general harbor a huge potential as diagnostic and prognostic markers as well as potential therapeutic targets in cancer.The miR-17-92 cluster was found to be overexpressed in many human cancers and to promote unrestrained cell growth, and has therefore been termed onco-miR-1...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28753865/prognostic-biomarkers-used-for-localised-prostate-cancer-management-a-systematic-review
#18
REVIEW
Pierre-Jean Lamy, Yves Allory, Anne-Sophie Gauchez, Bernard Asselain, Philippe Beuzeboc, Patricia de Cremoux, Jacqueline Fontugne, Agnès Georges, Christophe Hennequin, Jacqueline Lehmann-Che, Christophe Massard, Ingrid Millet, Thibaut Murez, Marie-Hélène Schlageter, Olivier Rouvière, Diana Kassab-Chahmi, François Rozet, Jean-Luc Descotes, Xavier Rébillard
CONTEXT: Prostate cancer stratification is based on tumour size, pretreatment PSA level, and Gleason score, but it remains imperfect. Current research focuses on the discovery and validation of novel prognostic biomarkers to improve the identification of patients at risk of aggressive cancer or of tumour relapse. OBJECTIVE: This systematic review by the Intergroupe Coopérateur Francophone de Recherche en Onco-urologie (ICFuro) analysed new evidence on the analytical validity and clinical validity and utility of six prognostic biomarkers (PHI, 4Kscore, MiPS, GPS, Prolaris, Decipher)...
March 7, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28752827/clinical-pathway-for-patients-with-chronic-myeloid-leukaemia-the-euriclea-project
#19
Stefano Botti, Gianpaolo Gargiulo, Felice Bombaci, Giovanna Artioli, Chiara Cosentino, Adriana Concetta Pignatelli, Daniela Torino, Maria Marcella Lionetti, Emanuela Samarani, Lorella Cappucciati, Paola Bordiga, Antonella Diodati, Cristiana Caffarri, Irene Rosini, Fabrizio Pane
BACKGROUND AND AIMS: The use of Tirosine Kinase Ihnibitors (TKIs) for the treatment of Chronic Myeloid Leukemia (CML) has definitely represented a turning point in the treatment of the onco-hematological diseases. Over the years, the interest of physicians, nurses, patients and caregivers has increasingly focused on the aspects of the humanization of care, the management of side effects and on the full and constant therapeutic adherence. The aim of the project was to define patient-oriented care processes, based on a proactive approach that can fully respond to the new health needs of CML patients...
July 18, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28749989/respiratory-events-in-ward-are-associated-with-later-intensive-care-unit-icu-admission-and-hospital-mortality-in-onco-hematology-patients-not-admitted-to-icu-after-a-first-request
#20
Laure Doukhan, Magali Bisbal, Laurent Chow-Chine, Antoine Sannini, Jean Paul Brun, Sylvie Cambon, Lam Nguyen Duong, Marion Faucher, Djamel Mokart
INTRODUCTION: Prognostic impact of delayed intensive care unit(ICU) admission in critically ill cancer patients remains debatable. We determined predictive factors for later ICU admission and mortality in cancer patients initially not admitted after their first ICU request. METHODS: All cancer patients referred for an emergency ICU admission between 1 January 2012 and 31 August 2013 were included. RESULTS: Totally, 246(54.8%) patients were immediately admitted...
2017: PloS One
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