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https://www.readbyqxmd.com/read/28522182/hodotopy-neuroplasticity-and-diffuse-gliomas
#1
H Duffau
BACKGROUND AND PURPOSE: The historical approach in neurooncology is used to mainly investigate the tumor, with very few considerations regarding the brain itself. Nonetheless, to select the best personalized therapeutic management for each patient with a diffuse glioma, i.e. to optimize the "onco-functional balance", the brain reaction induced by glioma growth and migration should be studied. Indeed, due to strong interactions between the glioma and the brain, cerebral adaptive phenomena often occur in order to maintain neurological and cognitive functions, as well as to compensate glioma spreading...
May 15, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28511670/onco-testicular-sperm-extraction-onco-tese-for-bilateral-testicular-tumors-two-case-reports
#2
Sohgo Tsutsumi, Takashi Kawahara, Teppei Takeshima, Sawako Chiba, Koichi Uemura, Masako Otani, Kota Shimokihara, Yutaro Hayashi, Taku Mochizuki, Daiji Takamoto, Yusuke Hattori, Jun-Ichi Teranishi, Yasuhide Miyoshi, Masahiro Yao, Yoshiaki Inayama, Yasushi Yumura, Hiroji Uemura
BACKGROUND: Most patients with testicular cancer are infertile; thus, the preservation of the sperm after surgery is an important factor to consider. We report two cases of bilateral testicular cancer in patients who underwent bilateral higher orchiectomy and simultaneous testicular sperm extraction. CASE PRESENTATION: Two Asian-Japanese men were referred to our hospital with bilateral testicular tumors. Both of the patients were preoperatively diagnosed with azoospermia and requested testicular sperm extraction at the time of higher orchiectomy...
May 17, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28505193/the-drosophila-orthologue-of-the-int6-onco-protein-regulates-mitotic-microtubule-growth-and-kinetochore-structure
#3
Fioranna Renda, Claudia Pellacani, Anton Strunov, Elisabetta Bucciarelli, Valeria Naim, Giuseppe Bosso, Elena Kiseleva, Silvia Bonaccorsi, David J Sharp, Alexey Khodjakov, Maurizio Gatti, Maria Patrizia Somma
INT6/eIF3e is a highly conserved component of the translation initiation complex that interacts with both the 26S proteasome and the COP9 signalosome, two complexes implicated in ubiquitin-mediated protein degradation. The INT6 gene was originally identified as the insertion site of the mouse mammary tumor virus (MMTV), and later shown to be involved in human tumorigenesis. Here we show that depletion of the Drosophila orthologue of INT6 (Int6) results in short mitotic spindles and deformed centromeres and kinetochores with low intra-kinetochore distance...
May 15, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28495035/selection-of-bacillus-thuringiensis-strains-toxic-to-cotton-boll-weevil-anthonomus-grandis-coleoptera-curculionidae-larvae
#4
Melisa P Pérez, Diego H Sauka, María I Onco, Marcelo F Berretta, Graciela B Benintende
Preliminary bioassays with whole cultures (WC) of 124 Bacillus thuringiensis strains were performed with neonate larvae of Anthonomus grandis, a major cotton pest in Argentina and other regions of the Americas. Three exotic and four native strains were selected for causing more than 50% mortality. All of them were β-exotoxin producers. The native strains shared similar morphology of parasporal crystals, similar protein pattern and identical insecticidal gene profiles. These features resembled Lepidoptera-toxic strains...
May 8, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28488971/quality-assessment-and-transfusion-efficacy-of-buffy-coat-derived-platelet-concentrates-washed-with-platelet-additive-solution
#5
Hermógenes Fernández-Muñoz, Cristina Castilla-Llorente, Eva M Plaza, Cristina Martínez-Millán, Inmaculada Heras, Pastora Iniesta, María L Amigo, Francisca Ferrer-Marin, María J Candela, María L Lozano, Vicente Vicente, José Rivera
BACKGROUND: Transfusion of washed platelet concentrates (W-PC) is recommended for some patients, such as those who have had previous severe allergic transfusion reactions. However, we still lack a standardised method for preparing these products. Here, we assessed the effect of a manual washing procedure on in vitro platelet quality and on the transfusion efficacy of W-PCs. MATERIALS AND METHODS: Buffy coat-derived W-PC in Composol solution were prepared by onestep centrifugation...
April 13, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28486238/dermoscopy-of-malignant-skin-tumours-what-s-new
#6
Teresa Russo, Vincenzo Piccolo, Aimilios Lallas, Jason Jacomel, Elvira Moscarella, Roberto Alfano, Giuseppe Argenziano
Dermoscopy represents a new and effective tool that assists dermatologists in improving the accuracy of clinical diagnosis in onco-dermatology. The aim of this article is to provide an overview of the latest and important dermoscopic progress and observations in this ever-evolving field of dermatology.
May 10, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28483482/-sexual-consequences-after-treatment-of-prostate-cancer-inquiry-among-members-of-the-association-nationale-des-malades-du-cancer-de-la-prostate
#7
D Girier, A Chevrot, P Costa, R Thuret, A Faix, A Mestre, S Droupy
INTRODUCTION: Complications of prostate cancer treatments are responsible of a lower quality of life. We evaluated the prevalence and the perceptions of sexual consequences of prostate cancer treatments. MATERIALS AND METHODS: A retrospective self-administered questionnaire was sent to all the members of the Association Nationale des Malades du Cancer de la Prostate (ANAMACAP). All the answers were analyzed. RESULTS: 226 questionnaires were analyzed, the average age was 67...
May 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28473255/inhibition-of-akt-and-other-agc-kinases-a-target-for-clinical-cancer-therapy
#8
REVIEW
Vincent Prêtre, Andreas Wicki
AGC kinases have been identified to contribute to cancer development and progression. Currently, most AGC inhibitors in clinical development are Akt inhibitors such as MK-2206 or GDC-0068, which are known to promote cell growth arrest and to sensitize cancer cells to radiotherapy. Response rates in clinical trials with single agent Akt inhibitors are typically low. The observed adverse events are within the expected limits for compounds inhibiting the PI3K-mTOR axis. Preclinical and early clinical data for combination therapies are accumulating...
May 1, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28468276/oleuropein-and-cancer-chemoprevention-the-link-is-hot
#9
REVIEW
Ammad Ahmad Farooqi, Sundas Fayyaz, Ana Sanches Silva, Antoni Sureda, Seyed Fazel Nabavi, Andrei Mocan, Seyed Mohammad Nabavi, Anupam Bishayee
Cancer comprises a collection of related diseases characterized by the existence of altered cellular pathways resulting in an abnormal tendency for uncontrolled growth. A broad spectrum, coordinated, and personalized approach focused on targeting diverse oncogenic pathways with low toxicity and economic natural compounds can provide a real benefit as a chemopreventive and/or treatment of this complex disease. Oleuropein, a bioactive phenolic compound mainly present in olive oil and other natural sources, has been reported to modulate several oncogenic signalling pathways...
April 29, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28468025/science-as-religion-when-science-becomes-too-irrational
#10
Amir Muzur, Iva Rinčić
Science is expected to be objective: however, since practiced and produced by humans, it has to reflect human flows - prejudices, stubbornness, malice, and the tendency to be misused. No wonder an excellent scientist like John Eccles proclaimed science to be among the most personal activities he had known. By analysing a few examples from the history of science (in particular the intellectual development of Van Rensselaer Potter, the American onco-biochemist and bioethics pioneer), as well as the current trend of the evidence-based approach, the present paper will try to demonstrate that denying, distrusting, and opposing science for the sake of religion, as seen so many times in human history, has significant similarities to the overestimation of science we more often encounter in our times...
April 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28441737/commitment-of-scaffold-proteins-in-the-onco-biology-of-human-colorectal-cancer-and-liver-metastases-after-oxaliplatin-based-chemotherapy
#11
Deborah Rotoli, Manuel Morales, Julio Ávila, María Del Carmen Maeso, María Del Pino García, Ali Mobasheri, Pablo Martín-Vasallo
Scaffold proteins play pivotal roles in the regulation of signaling pathways, integrating external and internal stimuli to various cellular outputs. We report the pattern of cellular and subcellular expression of scaffoldins angiomotin-like 2 (AmotL2), FK506 binding protein 5 (FKBP51) and IQ motif containing GTPase-activating protein 1 (IQGAP1) in colorectal cancer (CRC) and metastases in liver resected after oxaliplatin-based chemotherapy (CT). Positive immunostaining for the three scaffoldins was found in most cells in healthy colon, tumor, healthy liver and metastasized liver...
April 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28398925/urgent-chemotherapy-for-life-threatening-complications-related-to-solid-neoplasms
#12
Yoann Zerbib, Antoine Rabbat, Muriel Fartoukh, Naïke Bigé, Claire Andréjak, Julien Mayaux, Nicolas De Prost, Benoît Misset, Virginie Lemiale, Fabrice Bruneel, Julien Maizel, Sylvie Ricome, Frédéric Jacobs, Caroline Bornstain, Hervé Dupont, François Baudin, Elie Azoulay, Frédéric Pène
OBJECTIVES: Solid neoplasms can be directly responsible for organ failures at the time of diagnosis or relapse. The management of such specific complications relies on urgent chemotherapy and eventual instrumental or surgical procedures, combined with advanced life support. We conducted a multicenter study to address the prognosis of this condition. DESIGN: A multicenter retrospective (2001-2015) chart review. SETTING: Medical and respiratory ICUs...
April 10, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28391984/-french-national-survey-on-incoming-phone-calls-in-oncology-departments
#13
Florence Joly, Aline Guillot, Yann-Alexandre Vano, Dominique Spaeth, Delphine Topart, Pascal Roffet, Rachid El Amarti, Ali Hasbini, Aude Fléchon
INTRODUCTION: Oral therapies have shifted the follow-up of patients with cancer from hospital to home. As a consequence, the number of incoming calls has increased. To understand the source, reasons, management and burden of calls, we underwent a French national survey. The objective was to describe the way calls are managed in oncology departments. METHODS: The study was a prospective survey in a representative sample of French oncology specialists using oral therapies...
April 6, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28389669/exploring-functions-of-long-noncoding-rnas-across-multiple-cancers-through-co-expression-network
#14
Suqing Li, Bin Li, Yuanting Zheng, Menglong Li, Leming Shi, Xuemei Pu
In contrast to protein-coding genes, long-noncoding RNAs (lncRNAs) are much less well understood, despite increasing evidence indicating a wide range of their biological functions, and possible roles in various cancers. Based on public RNA-seq datasets of four solid cancer types, we here utilize Weighted Correlation Network Analysis (WGCNA) to propose a strategy for exploring the functions of lncRNAs altered in more than two cancer types, which we call onco-lncRNAs. Results indicate that cancer-expressed lncRNAs show high tissue specificity and are weakly expressed, more so than protein-coding genes...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28386333/microrna-150-regulates-glycolysis-by-targeting-von-hippel-lindau-in-glioma-cells
#15
Shi-Jie Li, Hong-Lin Liu, Shi-Lei Tang, Xiao-Juan Li, Xiao-Yin Wang
Warburg effect, characterized by enhanced glycolysis and lactate production, even under aerobic conditions, is one of the hallmarks of cancer cells. However, the mechanism underlying this phenomenon remains poorly understood. Previous studies have shown that microRNA-150 (miR-150) is significantly up-regulated in various malignancies and represents a putative onco-miRNA in human cancers. In the present study, we aim to investigate the functional significance and molecular target of miR-150 in glioma. As a result, von Hippel-Lindau (VHL), which is a specific E3 ligase for hypoxia inducible factor 1 (HIF1α), was identified as a novel target of miR-150...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28364980/sexual-quality-of-life-and-needs-for-sexology-care-of-cancer-patients-admitted-for-radiotherapy-a-3-month-cross-sectional-study-in-a-regional-comprehensive-reference-cancer-center
#16
Thierry Almont, Martine Delannes, Anne Ducassou, André Corman, Pierre Bondil, Elizabeth Moyal, Leslie Schover, Eric Huyghe
BACKGROUND: Providing early and better care in onco-sexuality and a better understanding of the sexual health care needs of patients before they start treatment is required. OBJECTIVE: To assess sexual quality of life and need for sexology care of patients when they are starting radiotherapy. DESIGN: We performed a cross-sectional study of adult patients with cancer admitted for radiotherapy treatment in a regional comprehensive cancer center...
April 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28359057/the-versatile-role-of-microrna-30a-in-human-cancer
#17
Xiang Yang, Yitian Chen, Longbang Chen
MicroRNAs (miRNAs) are a group of noncoding RNA molecules of 20-23 nucleotides length that negatively regulate gene expressions in numerous cellular processes. Through complementary paring with target mRNAs, miRNAs have frequently emerged as dual regulators of cancer development by acting on multiple signaling pathways, thereby act as novel biomarkers for cancer diagnosis, prognosis, and prediction of response to treatment. As one of them, miR-30a has been found to act as an onco-suppressor of tumorigenesis pathways through inhibition of cellular proliferation, migration and invasion...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28358704/prevalence-of-neurotropic-viruses-in-malignant-glioma-and-their-onco-modulatory-potential
#18
Tadej Strojnik, Darja Duh, Tamara T Lah
BACKGROUND: the association between infectious agents and tumour aetiology is relevant in about 20% of cases. PATIENTS AND METHODS: We tested high-grade glioma tissues from 45 patients for the presence of viral nucleic acids of six herpes viruses, human adenoviruses (A-G), and two neurotropic human viruses (enteroviruses, tick-borne encephalitis virus). Real-time polymerase chain reaction was used with immunolabelling. RESULTS: Three species of herpes viruses were detected: HSV-2, Epstein-Barr virus (EBV), HHV-6, and one human enterovirus...
March 2017: In Vivo
https://www.readbyqxmd.com/read/28350509/epstein-barr-virus-and-its-association-with-fascin-expression-in-colorectal-cancers-in-the-syrian-population-a-tissue-microarray-study
#19
Noor Al-Antary, Hanan Farghaly, Tahar Aboulkassim, Amber Yasmeen, Nizar Akil, Ala-Eddin Al Moustafa
Colorectal cancer (CRC) is the third most common malignancy in both men and women worldwide. Colorectal carcinogenesis is a complex, multistep process involving environmental and lifestyle features as well as sequential genetic changes in addition to bacterial and viral infections. Viral infection has a proven role in the incidence of approximately 20% of human cancers including gastric malignancies. Accordingly, Epstein-Barr virus (EBV) has been recently shown to be present in human gastric cancers, which could play an important role in the initiation and progression of these cancers...
March 28, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28345464/microrna-590-3p-promotes-cell-proliferation-and-invasion-by-targeting-inositol-polyphosphate-4-phosphatase-type-ii-in-human-prostate-cancer-cells
#20
Haiwen Chen, Qidong Luo, Hongliang Li
Inositol polyphosphate 4-phosphatase type II emerges as a tumor suppressor in prostate cancer, and its loss of expression is associated with poor prognosis for prostate cancer. However, the mechanism of downregulation of inositol polyphosphate 4-phosphatase type II in prostate cancer development has not yet been fully clarified. In this study, microRNA-590-3p was found to be upregulated in both prostate cancer tissues and cell lines. Overexpression of microRNA-590-3p by microRNA-590-3p mimics promoted prostate cancer cell proliferation and invasion and accelerated the growth of xenografted tumors, while microRNA-590-3p inhibitors contributed to inhibition of cellular proliferation and invasion as well as tumor growth...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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