keyword
https://read.qxmd.com/read/38523303/recurrent-severe-hypocalcemia-following-chemotherapy-regimen-changes-in-advanced-breast-cancer-two-case-reports
#21
JOURNAL ARTICLE
Yurina Yanase, Hiroko Bando, Riko Sato, Tomohei Matsuo, Aya Ueda, Mai Okazaki, Sachie Hashimoto, Akiko Iguchi-Manaka, Hisato Hara
BACKGROUND: As an oncologic emergency related to abnormalities in calcium metabolism, hypercalcemia associated with paraneoplastic syndrome and bone metastases is well known. Meanwhile, the incidence of hypocalcemia is low, except in cases associated with bone-modifying agents used for bone metastases. Hypocalcemia induced by bone-modifying agents typically occurs early after the initial administration, and its incidence can be significantly reduced by preventive administration of calcium and vitamin D3 supplements...
March 25, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38523186/multi-omic-profiling-of-simultaneous-ductal-carcinoma-in-situ-and-invasive-breast-cancer
#22
JOURNAL ARTICLE
Henry G Kaplan, Alexa K Dowdell, Anna B Berry, Racheli Ben Shimol, Fred L Robinson, Christopher A Carney, Brian D Piening
PURPOSE: The progression of ductal carcinoma in situ (DCIS) to invasive breast carcinoma (IBC) in humans is highly variable. To better understand the relationship between them, we performed a multi-omic characterization of co-occurring DCIS and IBC lesions in a cohort of individuals. METHODS: Formalin-fixed paraffin-embedded tissue samples from 50 patients with co-occurring DCIS and IBC lesions were subjected to DNA-seq and whole transcriptome RNA-seq. Paired DCIS and IBC multi-omics profiles were then interrogated for DNA mutations, gene expression profiles and pathway analysis...
March 24, 2024: Breast Cancer Research and Treatment
https://read.qxmd.com/read/38520579/clinicopathological-predictors-of-positive-resection-margins-in-breast-conserving-surgery
#23
JOURNAL ARTICLE
Hemali Chauhan, Natasha Jiwa, Vikneswaran Raj Nagarajan, Paul Thiruchelvam, Katy Hogben, Ragheed Al-Mufti, Dimitri Hadjiminas, Sami Shousha, Ramsey Cutress, Hutan Ashrafian, Zoltan Takats, Daniel Richard Leff
BACKGROUND: Ductal carcinoma in situ (DCIS) is associated with risk of positive resection margins following breast-conserving surgery (BCS) and subsequent reoperation. Prior reports grossly underestimate the risk of margin positivity with IBC containing a DCIS component (IBC + DCIS) due to patient-level rather than margin-level analysis. OBJECTIVE: The aim of this study was to delineate the relative risk of IBC + DCIS compared with pure IBC (without a DCIS component) on margin positivity through detailed margin-level interrogation...
March 23, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38519745/artificial-intelligence-algorithm-accurately-assesses-oestrogen-receptor-immunohistochemistry-in-metastatic-breast-cancer-cytology-specimens-a-pilot-study
#24
JOURNAL ARTICLE
Brenna C Li, Scott Hammond, Anil V Parwani, Rulong Shen
OBJECTIVE: The Visiopharm artificial intelligence (AI) algorithm for oestrogen receptor (ER) immunohistochemistry (IHC) in whole slide images (WSIs) has been successfully validated in surgical pathology. This study aimed to assess its efficacy in cytology specimens. METHODS: The study cohort comprised 105 consecutive cytology specimens with metastatic breast carcinoma. ER IHC WSIs were seamlessly integrated into the Visiopharm platform from the Image Management System (IMS) during our routine digital workflow, and an AI algorithm was employed for analysis...
March 22, 2024: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/38519642/zeb1-controls-a-lineage-specific-transcriptional-program-essential-for-melanoma-cell-state-transitions
#25
JOURNAL ARTICLE
Simon Durand, Yaqi Tang, Roxane M Pommier, Valentin Benboubker, Maxime Grimont, Felix Boivin, Laetitia Barbollat-Boutrand, Eric Cumunel, Florian Dupeuble, Anaïs Eberhardt, Maud Plaschka, Stéphane Dalle, Julie Caramel
Cell plasticity sustains intra-tumor heterogeneity and treatment resistance in melanoma. Deciphering the transcriptional mechanisms governing reversible phenotypic transitions between proliferative/differentiated and invasive/stem-like states is required. Expression of the ZEB1 transcription factor is frequently activated in melanoma, where it fosters adaptive resistance to targeted therapies. Here, we performed a genome-wide characterization of ZEB1 transcriptional targets, by combining ChIP-sequencing and RNA-sequencing, upon phenotype switching in melanoma models...
March 22, 2024: Oncogene
https://read.qxmd.com/read/38519456/nuclear-localization-of-heparanase-2-hpa2-attenuates-breast-carcinoma-growth-and-metastasis
#26
JOURNAL ARTICLE
Maram Hilwi, Katherina Shulman, Inna Naroditsky, Sari Feld, Miriam Gross-Cohen, Ilanit Boyango, Soaad Soboh, Olga Vornicova, Malik Farhoud, Preeti Singh, Gil Bar-Sela, Hadassah Goldberg, Martin Götte, Andrew D Sharrocks, Yaoyong Li, Ralph D Sanderson, Neta Ilan, Israel Vlodavsky
Unlike the intense research effort devoted to exploring the significance of heparanase in cancer, very little attention was given to Hpa2, a close homolog of heparanase. Here, we explored the role of Hpa2 in breast cancer. Unexpectedly, we found that patients endowed with high levels of Hpa2 exhibited a higher incidence of tumor metastasis and survived less than patients with low levels of Hpa2. Immunohistochemical examination revealed that in normal breast tissue, Hpa2 localizes primarily in the cell nucleus...
March 22, 2024: Cell Death & Disease
https://read.qxmd.com/read/38519275/exploratory-pilot-study-to-characterize-the-immune-landscapes-of-malignant-pleural-effusions-and-their-corresponding-primary-tumors-from-patients-with-breast-carcinoma-and-lung-adenocarcinoma
#27
JOURNAL ARTICLE
Caddie Laberiano-Fernandez, Qiong Gan, Sophia Mei Wang, Auriole Tamegnon, Ignacio Wistuba, Esther Yoon, Sinchita Roy-Chowdhuri, Edwin Roger Parra
INTRODUCTION: Malignant pleural effusion (MPE) is a frequent complication of advanced malignancies. In this pilot study, we characterized the immune landscapes of MPEs, compared them to their primary tumor (PT) samples from breast carcinoma (BC) and lung adenocarcinoma (LADC), and tested the utility of multiplexed image technology in cytological samples. MATERIALS AND METHODS: We evaluated the immune contexture of 6 BC and 5 LADC MPEs and their PTs using 3 multiplex immunofluorescence panels...
February 29, 2024: Journal of the American Society of Cytopathology
https://read.qxmd.com/read/38518464/primary-cutaneous-apocrine-carcinoma-a-challenging-case-report
#28
Nayssem Khessairi, Yasmine Fertani, Saida Sakhri, Imen Abbess, Ines Zemni, Tarek Ben Dhiab
INTRODUCTION: Primary cutaneous apocrine carcinomas of the axilla represents an extremely rare entity, with <200 cases reported in the literature. It can be challenging, even almost impossible, to distinguish histologically from metastases of breast origin. We herein present the first case of an axillary cutaneous apocrine adenocarcinoma followed and treated in our institute. CASE PRESENTATION: A 58-year-old man with a history of myopathy, presented for a right axillary swelling...
March 14, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38518165/re-evaluation-of-ipsilateral-multiple-focal-breast-cancer-case-report-and-literature-review
#29
JOURNAL ARTICLE
Lei Hou, Ziyi Fan, Luming Zheng
OBJECTIVE: Ipsilateral multiple breast cancer is a unique situation in which multiple breast cancer lesions are present in the same or different quadrant of the breast. While current research on ipsilateral multiple breast cancer primarily focuses on its existence or heterogeneity, it is important to evaluatethe risk level stratification of heterogenous lesion and determine the intensity of anti-tumor treatments for every lesion, achieving a rational and personalized anti-cancer strategy...
March 22, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38517441/intraoperative-evaluation-of-breast-tissues-during-breast-cancer-operations-using-the-masspec-pen
#30
JOURNAL ARTICLE
Kyana Y Garza, Mary E King, Chandandeep Nagi, Rachel J DeHoog, Jialing Zhang, Marta Sans, Anna Krieger, Clara L Feider, Alena V Bensussan, Michael F Keating, John Q Lin, Min Woo Sun, Robert Tibshirani, Christopher Pirko, Kirtan A Brahmbhatt, Ahmed R Al-Fartosi, Alastair M Thompson, Elizabeth Bonefas, James Suliburk, Stacey A Carter, Livia S Eberlin
IMPORTANCE: Surgery with complete tumor resection remains the main treatment option for patients with breast cancer. Yet, current technologies are limited in providing accurate assessment of breast tissue in vivo, warranting development of new technologies for surgical guidance. OBJECTIVE: To evaluate the performance of the MasSpec Pen for accurate intraoperative assessment of breast tissues and surgical margins based on metabolic and lipid information. DESIGN, SETTING, AND PARTICIPANTS: In this diagnostic study conducted between February 23, 2017, and August 19, 2021, the mass spectrometry-based device was used to analyze healthy breast and invasive ductal carcinoma (IDC) banked tissue samples from adult patients undergoing breast surgery for ductal carcinomas or nonmalignant conditions...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38516685/clinical-analysis-of-metaplastic-breast-carcinoma-with-distant-metastases-a-multi%C3%A2-centre-experience
#31
JOURNAL ARTICLE
Mirosława Püsküllüoğlu, Katarzyna Swiderska, Aleksandra Konieczna, Joanna Streb, Aleksandra Grela-Wojewoda, Agnieszka Rudzinska, Jolanta Dobrzańska, Renata Pacholczak-Madej, Anna Mucha-Malecka, Michał Kunkiel, Jerzy W Mitus, Michał Jarząb, Marek Ziobro
Metaplastic breast cancer (BC-Mp), which includes a range of epithelial and mixed epithelial-mesenchymal tumours, are rare malignancies with an unfavourable prognosis. The limited literature on BC-Mp focuses mainly on retrospective data for radically treated patients. Notably absent are studies dedicated to the palliative treatment of BC-Mp with distant metastases. The present retrospective study investigated treatment modalities and prognosis in a multi-centre cohort of 31 female participants diagnosed with distant metastatic BC-Mp, including 7 patients with de novo metastatic disease...
May 2024: Oncology Letters
https://read.qxmd.com/read/38515856/article-review-brazilin-as-potential-anticancer-agent
#32
REVIEW
Callista Najla Raptania, Syifa Zakia, Alistia Ilmiah Fahira, Riezki Amalia
Brazilin is the main compound in Caesalpinia sappan and Haematoxylum braziletto , which is identified as a homoisoflavonoid based on its molecular structure. These plants are traditionally used as an anti-inflammatory to treat fever, hemorrhage, rheumatism, skin problems, diabetes, and cardiovascular diseases. Recently, brazilin has increased its interest in cancer studies. Several findings have shown that brazilin has cytotoxic effects on colorectal cancer, breast cancer, lung cancer, multiple myeloma, osteosarcoma, cervical cancer, bladder carcinoma, also other cancers, along with numerous facts about its possible mechanisms that will be discussed...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38515774/paclitaxel-combined-with-trastuzumab-chemotherapy-related-posterior-reversible-encephalopathy-syndrome-a-case-report-and-literature-review
#33
Jing Li, Yanlan Huang, Qifang Lao
Posterior reversible encephalopathy syndrome (PRES) in breast carcinoma is a rare disease in clinical practice that is often misdiagnosed and ignored. This study reported a case of a patient admitted to our hospital and discussed the clinical, imaging, and pathogenesis properties of the disease. We retrospectively analyzed the clinical data of this patient and reviewed the relevant literature. Imaging was used to diagnose PRES based on clinical findings, and clinical symptoms improved after discontinuation of the relevant drugs...
June 2024: Radiology Case Reports
https://read.qxmd.com/read/38515725/knowledge-domains-and-emerging-trends-in-immune-related-adverse-events-from-immune-checkpoint-inhibitors-a-bibliometrics-and-visualized-analysis
#34
JOURNAL ARTICLE
Jun Zhao, Yujie Feng, Guang-Wei Liu
OBJECTIVE: The primary objective of this paper is to investigate the research hotspots and future trends of immune-related adverse events induced by immune checkpoint inhibitors, offering valuable insights for researchers in this field. METHODOLOGY: Using the visual analysis software, this study conducted quantitative statistics and visualization research on the relevant literature concerning immune-related adverse events caused by immune checkpoint inhibitors in the Web of Science Core Collection Database...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38515278/prom2-overexpression-induces-metastatic-potential-through-epithelial-to-mesenchymal-transition-and-ferroptosis-resistance-in-human-cancers
#35
JOURNAL ARTICLE
Justine Paris, Claire Wilhelm, Celeste Lebbé, Mohammed Elmallah, Frédéric Pamoukdjian, Audrey Héraud, Guillaume Gapihan, Aurore Van De Walle, Van Nhan Tran, Diaddin Hamdan, Clara Allayous, Maxime Battistella, Emmanuel Van Glabeke, Kah Wai Lim, Christophe Leboeuf, Sébastien Roger, Géraldine Falgarone, Anh Tuan Phan, Guilhem Bousquet
INTRODUCTION: Despite considerable therapeutic advances in the last 20 years, metastatic cancers remain a major cause of death. We previously identified prominin-2 (PROM2) as a biomarker predictive of distant metastases and decreased survival, thus providing a promising bio-target. In this translational study, we set out to decipher the biological roles of PROM2 during the metastatic process and resistance to cell death, in particular for metastatic melanoma. METHODS AND RESULTS: Methods and results: We demonstrated that PROM2 overexpression was closely linked to an increased metastatic potential through the increase of epithelial-to-mesenchymal transition (EMT) marker expression and ferroptosis resistance...
March 2024: Clinical and Translational Medicine
https://read.qxmd.com/read/38515107/factors-associated-with-engraftment-success-of-patient-derived-xenografts-of-breast-cancer
#36
JOURNAL ARTICLE
Jongwon Lee, GunHee Lee, Hye Seon Park, Byung-Kwan Jeong, Gyungyub Gong, Jae Ho Jeong, Hee Jin Lee
BACKGROUND: Patient-derived xenograft (PDX) models serve as a valuable tool for the preclinical evaluation of novel therapies. They closely replicate the genetic, phenotypic, and histopathological characteristics of primary breast tumors. Despite their promise, the rate of successful PDX engraftment is various in the literature. This study aimed to identify the key factors associated with successful PDX engraftment of primary breast cancer. METHODS: We integrated clinicopathological data with morphological attributes quantified using a trained artificial intelligence (AI) model to identify the principal factors affecting PDX engraftment...
March 21, 2024: Breast Cancer Research: BCR
https://read.qxmd.com/read/38515093/clinical-outcomes-of-screening-and-diagnostic-mammography-in-a-limited-resource-healthcare-system
#37
JOURNAL ARTICLE
Mahmoud Al-Balas, Hamzeh Al-Balas, Zain AlAmer, Ghadeer Al-Taweel, Aseel Ghabboun, Farh Al Bzoor, Sumaia Abumkarab, Tala Abu Bakr, Batool Eleiwat
INTRODUCTION: Breast cancer is a significant public health concern in Jordan. It is the most common cancer among Jordanian women. Despite its high incidence and advanced stage at time of diagnosis, the uptake of breast cancer screening in Jordan is low. This study aims to compare clinical outcomes of both screening and diagnostic mammogram among women in Jordan. METHODS: A retrospective cohort of 1005 women who underwent mammography in breast imaging unit in a tertiary hospital in Jordan...
March 21, 2024: BMC Women's Health
https://read.qxmd.com/read/38514057/elevated-mmp1-expression-in-carcinoma-associated-fibroblasts-of-breast-cancer-contributes-to-tumor-progression-and-unfavorable-prognosis
#38
JOURNAL ARTICLE
Chunfang Xi, Zhendi Song, Qingyu Cui, Ye Zhao, Kaifu Li, Hua Kang
OBJECTIVE: Previous studies have shown that cancer-associated fibroblasts (CAFs) may play a role in tumor growth and development through paracrine action. Several studies reported upregulated matrix metallopeptidase 1 (MMP1) expression in various cancers. The aim is to investigate the role of elevated MMP1 expression in CAFs of breast cancer. METHODS: A total of 203 cases were used for immunohistochemical analysis based on multiple clinical parameters. Tissues for primary cultures of CAFs were collected from 10 breast cancer patients who underwent complete surgical resection of their tumors...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38513191/comparison-of-clinicopathological-features-of-pleomorphic-and-invasive-lobular-breast-carcinomas
#39
JOURNAL ARTICLE
Mehmet F Sağdıç, Onur C Güler, Orkun Subaşı, Özhan Albayrak, Cihangir Özaslan
PURPOSE: Accounting for about 15% of invasive lobular carcinomas and 1% of breast carcinomas, pleomorphic lobular carcinoma is known to be a rare histological subtype of invasive lobular carcinoma. Yet, it is more aggressive and produces a worse prognosis than other breast cancers. Ultimately, the present study compares the clinicopathological features of pleomorphic and invasive lobular breast carcinomas. METHODS: In the study, we retrospectively evaluated the data of 262 patients with histological subtypes of classical and pleomorphic lobular cancers having been recruited for surgical operations...
March 21, 2024: American Surgeon
https://read.qxmd.com/read/38512628/long-term-outcome-of-9g-mri-guided-vacuum-assisted-breast-biopsy-results-of-293-single-center-procedures-and-underestimation-rate-of-high-risk-lesions-over-12%C3%A2-years
#40
JOURNAL ARTICLE
Giuseppe Rescinito, Nicole Brunetti, Alessandro Garlaschi, Simona Tosto, Licia Gristina, Benedetta Conti, Diletta Pieroni, Massimo Calabrese, Alberto Stefano Tagliafico
PURPOSE: Breast magnetic resonance imaging (MRI) can detect some malignant lesions that are not visible on mammography (MX) or ultrasound (US). If a targeted, second-look fails, MRI-guided breast biopsy is the only available tool to obtain a tissue sample and pathological proof of these "MRI-only lesions". The aim of this study is to report the performance and underestimation rate of 9G MRI-guided vacuum-assisted breast biopsy (VABB) over 12 years at a single center. MATERIAL AND METHODS: All 9G MRI-VABB procedures performed from January 2010 to December 2021 were retrospectively reviewed...
March 21, 2024: La Radiologia Medica
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