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https://www.readbyqxmd.com/read/29684820/increased-oxidative-stress-mediates-the-antitumor-effect-of-parp-inhibition-in-ovarian-cancer
#1
Dong Hou, Zhaojian Liu, Xiuhua Xu, Qiao Liu, Xiyu Zhang, Beihua Kong, Jian-Jun Wei, Yaoqin Gong, Changshun Shao
PARP inhibitors have been widely tested in clinical trials, especially for the treatment of breast cancer and ovarian cancer, and were shown to be highly successful. Because PARP primarily functions in sensing and repairing DNA strand breaks, the therapeutic effect of PARP inhibition is generally believed to be attributed to impaired DNA repair. We here report that oxidative stress is also increased by PARP inhibition and mediates the antitumor effect. We showed that PARP1 is highly expressed in specimens of high grade serous ovarian carcinoma and its activity is required for unperturbed proliferation of ovarian cancer cells...
March 30, 2018: Redox Biology
https://www.readbyqxmd.com/read/29684708/structural-based-design-synthesis-and-antitumor-activity-of-novel-alloxazine-analogues-with-potential-selective-kinase-inhibition
#2
Waleed H Malki, Ahmed M Gouda, Hamdy E A Ali, Rabaa Al-Rousan, Doaa Samaha, Ashraf N Abdalla, Juan Bustamante, Zakaria Y Abd Elmageed, Hamed I Ali
Protein kinases are promising therapeutic targets for cancer therapy. Here, we applied multiple approaches to optimize the potency and selectivity of our reported alloxazine scaffold. Flexible moieties at position 2 of the hetero-tricyclic system were incorporated to fit into the ATP binding site and extend to the adjacent allosteric site and selectively inhibit protein kinases. This design led to potential selective inhibition of ABL1, CDK1/Cyclin A1, FAK, and SRC kinase by 30-59%. Cytotoxicity was improved by ∼50 times for the optimized lead (10b; IC50  = 40 nM) against breast cancer (MCF-7) cells...
April 17, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29684697/new-arene-ruthenium-ii-complexes-of-4%C3%A2-aryl%C3%A2-4h%C3%A2-naphthopyrans-with-anticancer-and-anti-vascular-activities
#3
Florian Schmitt, Jana Kasparkova, Viktor Brabec, Gerrit Begemann, Rainer Schobert, Bernhard Biersack
A series of four 2‑amino‑3‑cyano‑4‑(3/4‑pyridyl)‑4H‑benzo[h]chromenes 2a-d and their dichlorido(p‑cymene)ruthenium(II) complexes 3a-d were tested for antiproliferative, vascular-disruptive, anti-angiogenic and DNA-binding activity. The coordination of the 4‑pyridyl‑4H‑naphthopyrans 2 to ruthenium led to complexes with pleiotropic effects. Unlike the free ligands 2a-d, their ruthenium complexes 3a-d showed a significant affinity for DNA as demonstrated by electrophoretic mobility shift assays (EMSA) and ethidium bromide assays...
April 5, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29683756/de-novo-expression-of-transfected-sirtuin-3-enhances-susceptibility-of-human-mcf-7-breast-cancer-cells-to-hyperoxia-treatment
#4
Marija Pinterić, Iva I Podgorski, Sandra Sobočanec, Marijana Popović Hadžija, Mladen Paradžik, Ana Dekanić, Maja Marinović, Mirna Halasz, Robert Belužić, Grazia Davidović, Andreja Ambriović Ristov, Tihomir Balog
Sirtuin 3 (Sirt3) has a promising role in cancer tumourigenesis and treatment, but there have been controversies about its role as oncogene or tumour suppressor in different types of cancer. Changes in its expression are associated with the excessive production of reactive oxygen species (ROS), thus contributing to mitochondrial dysfunction and age-related pathologies. Hyperoxic treatment (i.e. generator of ROS) was shown to support some tumourigenic properties, but finally suppresses growth of certain mammary carcinoma cells...
April 23, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29683229/stromal-immunoglobulin-%C3%AE%C2%BAc-expression-is-associated-with-initiation-of-breast-cancer-in-ta2-mice-and-human-breast-cancer
#5
Shiwu Zhang, Fei Fei, Hua Wang, Yanjun Gu, Chunyuan Li, Xinlu Wang, Yongjie Zhao, Yuwei Li
The initiation of spontaneous breast cancer (SBC) in Tientsin Albino 2 (TA2) mice is related to mouse mammary tumor virus (MMTV) infection, and MMTV amplification is hormonally regulated. To explore the insertion site of MMTVLTR in TA2 mouse genome, reverse PCR and nested PCR were used to amplify the unknown sequence on both sides of the MMTV-LTRSAG gene in SBC and normal breast tissue of TA2 mice. Furthermore, the clinicopathological significance of the insertion site was evaluated in 43 samples of normal breast tissue, 46 samples of breast cystic hyperplasia, 54 samples of ductal carcinoma in situ, 142 samples of primary breast cancer, and 47 samples of lymph node metastatic breast cancer by RNA in situ hybridization...
April 23, 2018: Cancer Science
https://www.readbyqxmd.com/read/29682554/differential-expression-patterns-of-eph-receptors-and-ephrin-ligands-in-human-cancers
#6
REVIEW
Chung-Ting Jimmy Kou, Raj P Kandpal
Eph receptors constitute the largest family of receptor tyrosine kinases, which are activated by ephrin ligands that either are anchored to the membrane or contain a transmembrane domain. These molecules play important roles in the development of multicellular organisms, and the physiological functions of these receptor-ligand pairs have been extensively documented in axon guidance, neuronal development, vascular patterning, and inflammation during tissue injury. The recognition that aberrant regulation and expression of these molecules lead to alterations in proliferative, migratory, and invasive potential of a variety of human cancers has made them potential targets for cancer therapeutics...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682433/a-comparative-review-of-demographics-incidence-and-epidemiology-of-histologically-confirmed-intracranial-tumors-in-brazil-and-bulgaria
#7
REVIEW
George S Stoyanov, Jonathan S Sarraf, Boyko K Matev, Deyan L Dzhenkov, Martina Kitanova, Bogomil Iliev, Peter Ghenev, Anton B Tonchev, Yavor Enchev, Fernando Adami, Luis Eduardo W De Carvalho
Intracranial tumors (ICTs) attract numerous scientific teams and tremendous financial resources worldwide. These lesions of the central nervous system (CNS) can be both benign and malignant in biological behavior as well as local or metastatic in origin. We compared data from two studies on primary and metastatic ICTs from Brazil and Bulgaria, based on histopathologically confirmed ICTs from tertiary health centers. Primary ICTs significantly outweigh the frequency of metastatic ICTs. Primary ICTs represent 86...
February 19, 2018: Curēus
https://www.readbyqxmd.com/read/29682200/small-molecule-cxcr4-antagonists-block-the-hiv-1-nef-cxcr4-axis-and-selectively-initiate-the-apoptotic-program-in-breast-cancer-cells
#8
Ming-Bo Huang, Kyle E Giesler, Brooke M Katzman, Anthony R Prosser, Valarie Truax, Dennis C Liotta, Lawrence J Wilson, Vincent C Bond
The chemokine receptor CXCR4 plays an integral role in the development of highly metastatic breast cancer and in the pathogenesis of chronic HIV infection. In this study, we compared the effects of CXCR4 antagonists on apoptosis induction in hematopoietic cells and in tumor cells. We incubated cells expressing CXCR4 with a series of CXCR4 antagonists and subsequently exposed the cultures to a pro-apoptotic peptide derived from the HIV-1 Nef protein (NefM1). The NefM1 peptide contains residues 50-60 of Nef and was previously shown to be the sequence necessary for Nef to initiate the apoptotic program through CXCR4 signaling...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29680858/relationship-between-histone-deacetylase-3-hdac3-and-breast-cancer
#9
Zhuhong Cui, Mingjun Xie, Zhenru Wu, Yujun Shi
BACKGROUND The modification of histone acetylation and deacetylation is the most important mechanism of chromatin remodeling. These modifications are a subset of epigenetic alterations which affect tumorigenesis and progression through changes in gene expression and cell growth. Results of histone modification studies prompted us to explore the therapeutic and prognostic significance of histone deacetylase 3 (HDAC3) expression in patients with breast cancer. MATERIAL AND METHODS Immunohistochemical (IHC) staining was used to detect HDAC3 expression in a tissue microarray (TMA) that included 145 patients diagnosed with invasive ductal breast carcinoma...
April 22, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29679553/potential-diagnostic-role-of-circulating-mirnas-in-breast-cancer-implications-on-clinicopathological-characters
#10
Menha Swellam, Hekmat M El Magdoub, Naglaa M Hassan, Mona M Hefny, Mohamed Emam Sobeih
BACKGROUND: Circulating miRNAs are stable in body fluids and resembles their levels in cancer tissue/cells. They have been expressed in many cancers among them is breast cancer. Authors aimed to investigate the expression level of three circulating oncomiRNAs (miRNA-21, miRNA-222 and miRNA-373) in serum samples as a minimally non-invasive method for early detection of breast cancer, and study their relation with clinicopathological characters. METHODS: MiRNAs expression levels were determined using quantitative real-time polymerase chain reaction (qPCR) in serum samples from three groups: primary breast cancer patients (n = 137), benign breast lesion patients (n = 60), and healthy individuals as control group (n = 38)...
April 18, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29679549/chm-1-a-novel-microtubule-destabilizing-agent-exhibits-antitumor-activity-via-inducing-the-expression-of-sirt2-in-human-breast-cancer-cells
#11
Chin-Wei Liu, Ying-Chao Lin, Chao-Ming Hung, Bing-Lan Liu, Sheng-Chu Kuo, Chi-Tang Ho, Tzong-Der Way, Chih-Hsin Hung
Breast cancer is a major public health problem throughout the world. In this report, we investigated whether CHM-1, a novel synthetic antimitotic agent could be developed into a potent antitumor agent for treating human breast cancer. CHM-1 induced growth inhibition in MDA-MB-231, MDA-MB-453 and MCF-7 cells in a concentration-dependent manner. Importantly, CHM-1 is less toxic to normal breast (HBL-100) cells. CHM-1 interacted with tubulin, markedly inhibited tubulin polymerization, and disrupted microtubule organization...
April 18, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29679219/rf-ablation-pattern-shaping-employing-switching-channels-of-dual-bipolar-needle-electrodes-ex-vivo-results
#12
Jens Ziegle, Chloé Audigier, Johannes Krug, Ghazanfar Ali, Younsu Kim, Emad M Boctor, Michael Friebe
PURPOSE: Radiofrequency (RF) ablation with mono- or bipolar electrodes is a common procedure for hepatocellular carcinoma (HCC) with a low rate of recurrence for small size tumors. For larger lesions and/or non-round/ellipsoid shapes RF ablation has some limitations and generally does not achieve comparable success rates to microwave ablation or high-intensity focused ultrasound therapies. MATERIALS AND METHODS: To shape RF ablations for matching a tumor size and geometry, we have developed an electronic channel switch box for two bipolar needles that generates multiple selectable ablation patterns...
April 20, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29678165/retrospective-analysis-of-the-impact-of-anthracycline-dose-reduction-and-chemotherapy-delays-on-the-outcomes-of-early-breast-cancer-molecular-subtypes
#13
Sigita Liutkauskiene, Saulius Grizas, Kristina Jureniene, Jorune Suipyte, Akvile Statnickaite, Elona Juozaityte
BACKGROUND: The objective of study was to determine the effect of anthracycline dose reduction and chemotherapy delays on 5-year overall survival in patients with stage I-III breast cancer, to establish the impact of molecular subtypes on the anthracycline modification effects and to analyze reasons for such chemotherapy scheme modifications. METHODS: Medical records of patients with stage I-III breast cancer were reviewed. Inclusion criteria involved stage I- III breast carcinoma; radical surgery performed and 4 courses of AC regimen (doxorubicin and cyclophosphamide), or at least 6 courses of FAC regimen (fluorouracil, doxorubicin and cyclophosphamide) completed; no neoadjuvant chemotherapy applied; no taxane group medications administered; medical records maintain comprehensive data on treatment and follow-up...
April 20, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29677398/does-stress-increase-risk-of-breast-cancer-a-15-year-prospective-study
#14
Phyllis Butow, Melanie Price, Joseph Coll, Katherine Tucker, Bettina Meiser, Roger Milne, Judith Wilson, Louise Heiniger, Brandi Baylock, Tracey Bullen, Prue Weideman, Kelly-Anne Phillips
OBJECTIVE: The possible impact of stress on cancer incidence remains controversial. We prospectively evaluated associations between life event stressors, social support, personality characteristics (optimism, anger control, anti-emotionality) and risk of developing primary breast cancer (BCa), in women at increased familial risk of BCa. METHODS: A prospective cohort, repeated measures design was employed. Recruitment was through the Kathleen Cuningham Foundation Consortium for Research into Familial breast cancer (kConFab), which collects genetic, epidemiological and clinical data from Australasian families with multiple BCa cases...
April 20, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29677171/does-bca3-play-a-role-in-the-hiv-1-replication-cycle
#15
Michaela Rumlová, Ivana Křížová, Jaroslav Zelenka, Jan Weber, Tomáš Ruml
The cellular role of breast carcinoma-associated protein (BCA3), also known as A-kinase-interacting protein 1 (AKIP-1), is not fully understood. Recently, we reported that full-length, but not C-terminally truncated, BCA3 is incorporated into virions of Mason-Pfizer monkey virus, and that BCA3 enhances HIV-1 protease-induced apoptosis. In the present study, we report that BCA3 is associated with purified and subtilisin-treated HIV particles. Using a combination of immune-based methods and confocal microscopy, we show that the C-terminus of BCA3 is required for packaging into HIV-1 particles...
April 20, 2018: Viruses
https://www.readbyqxmd.com/read/29676707/-ultrasound-guided-surgery-for-breast-cancer
#16
J H Volders, N M H Krekel, M H Haloua, S Meijer, M P van den Tol
Recent literature shows that perioperative ultrasound guidance of surgery for palpable and nonpalpable breast carcinoma results in improved surgical effectiveness. Ultrasound-guided surgery can easily lead to significant improvement of the number of radical resections and can decrease the need for additional surgery or extra radiotherapy. Ultrasound-guided surgery also contributes to a reduction in the amount of excessive breast tissue removal, which means the final cosmetic result is better. Ultrasound-guided surgery is cost-effective and easy to learn...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29676352/comparison-of-lymphangiogenesis-lymphatic-invasion-and-axillary-lymph-node-metastasis-in-breast-carcinoma
#17
Prerna Guleria, V Srinivas, D Basannar, Vibha Dutta
Context: Lymphangiogenesis correlates with poor prognosis in Invasive Ductal Carcinoma (IDC) breast. D2-40 antibody, a specific marker for lymphatic endothelium, differentiates lymphatic from vascular endothelium. Therefore, the aims of this study were to estimate lymphangiogenesis using D2-40 antibody and correlate with lymphatic invasion (LI) and axillary lymph node (LN) status and compare lymphatic mean vessel density (LMVD) with Tumor (T) and Node (N) stages and grade of tumor. Methods and Material: The study was conducted on fifty consecutive cases of IDC breast who underwent modified radical mastectomy (MRM) from Jan 2009 to March 2011...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29675931/efficacy-studies-of-sclerotium-rolfsii-lectin-on-breast-cancer-using-nod-scid-mouse-model
#18
Prajna Hegde, Jagadeesh Narasimhappagari, Bale M Swamy, Shashikala R Inamdar
Expression of altered glycans like TF, Tn and sTn antigens has been observed in a number of carcinomas which are targeted in cancer therapy. Sclerotium rolfsii lectin (SRL) is known to recognize TF and its substituted forms. Clinical potential of SRL has been demonstrated by studying its interaction with different types of cancer cells. Here we report, in vitro studies of SRL on breast cancer MDA-MB-468 cells and in vivo studies with MCF-7 xenografts. In vitro growth inhibitory studies of SRL on metastatic triple negative breast cancer MDA-MB-468 cells was performed by MTT assay, flow cytometry, adhesion and CAM assay...
April 20, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29675784/isolation-of-normal-fibroblasts-and-their-cancer-associated-counterparts-cafs-for-biomedical-research
#19
Barbora Dvořánková, Lukáš Lacina, Karel Smetana
Cancer-associated fibroblasts (CAFs) represent a crucial component of cancer microenvironment. CAFs significantly influence biological properties of various types of cancer in terms of local aggressiveness, recurrence, and metastatic behaviour. This chapter summarizes a simple protocol for isolation of normal fibroblasts and their cancer-associated counterparts from normal human skin and mucosa, respectively, as well as from samples of human tumours such as basal/squamous carcinoma, melanoma, and breast cancer, and employment of this procedure for other types of cancer is possible...
April 20, 2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29675107/reassessing-the-potential-of-myb-targeted-anti-cancer-therapy
#20
REVIEW
Xiaofeng Liu, Yunxiao Xu, Liping Han, Yan Yi
Transcription factor MYB is essential for the tumorigenesis of multiple cancers, especially leukemia, breast cancer, colon cancer, adenoid cystic carcinoma and brain cancer. Thus, MYB has been regarded as an attractive target for tumor therapy. However, pioneer studies of antisense oligodeoxynucleotides against MYB, which were launched three decades ago in leukemia therapy, were discontinued because of their unsatisfactory clinical outcomes. In recent years, the roles of MYB in tumor transformation have become increasingly clear...
2018: Journal of Cancer
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