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https://www.readbyqxmd.com/read/27904694/soluble-flt-1-improves-the-repair-of-ankle-joint-injury-in-rats
#1
Jing Tian, Bing Xie, Liangbi Xiang, Yong Zhao, Dapeng Zhou
The ankle injuries create great pain to a great number of patients worldwide. Past studies have focused on the development of practical treatments to relieve pain and improve recovery, but the molecular mechanisms underlying the ankle injuries, especially the local inflammation in the damaged ankle joint, have been rarely studied. Moreover, although reduction of production and secretion of pro-inflammatory cytokines may reduce the pain and promote the recovery, a practical approach is currently lacking. Here, we detected significantly higher levels of placental growth factor (PLGF) and pro-inflammatory cytokines in the joint fluid from the patients of acute ankle joint injury (AAJI)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27891549/a-pilot-study-of-the-diagnostic-and-prognostic-values-of-flt-pet-ct-for-pancreatic-cancer-comparison-with-fdg-pet-ct
#2
Masatoyo Nakajo, Yoriko Kajiya, Atsushi Tani, Megumi Jinguji, Masayuki Nakajo, Tohru Nihara, Yoshihiko Fukukura, Takashi Yoshiura
PURPOSE: The purpose of the study was to examine the diagnostic and prognostic values of (18)F-fluorothymidine (FLT)-PET/CT for pancreatic cancer by comparing with (18)F-fluorodeoxyglucose (FDG)-PET/CT. METHODS: Fifteen patients with newly diagnosed pancreatic cancer underwent both FLT and FDG-PET/CT scans before treatment. The sensitivity, specificity, and accuracy in detecting nodal and distant metastases were compared between both scans using McNemar exact or χ (2) test...
November 28, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27873232/evidence-based-revised-view-of-the-pathophysiology-of-preeclampsia
#3
Asif Ahmed, Homira Rezai, Sophie Broadway-Stringer
Preeclampsia is a life-threatening vascular disorder of pregnancy due to a failing stressed placenta. Millions of women risk death to give birth each year and globally each year, almost 300,000 lose their life in this process and over 500,000 babies die as a consequence of preeclampsia. Despite decades of research, we lack pharmacological agents to treat it. Maternal endothelial oxidative stress is a central phenomenon responsible for the preeclampsia phenotype of high maternal blood pressure and proteinuria...
November 22, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27871461/nuclear-factor-of-activated-t-cells-nfat-regulates-soluble-fms-like-tyrosine-kinase-1-secretion-sflt-1-from-human-placenta
#4
Louie Ye, Amy Gratton, Natalie J Hannan, Ping Cannon, Minh Deo, Kirsten R Palmer, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot
INTRODUCTION: Preeclampsia is a serious complication affecting 5-8% of pregnancies. Central to its pathogenesis is placental hypoxia and inflammation which leads to secretion of soluble fms-like tyrosine kinase 1 (sFlt-1). sFlt-1 causes widespread endothelial dysfunction. The molecular mechanisms regulating sFlt-1 production remain poorly understood. Recently, a binding site for the nuclear factor activated T cells (NFAT) transcription factor has been found on fms-like tyrosine kinase 1 (FLT-1) promoter...
December 2016: Placenta
https://www.readbyqxmd.com/read/27870972/mek-erk-signaling-is-involved-in-the-role-of-vegf-and-igf1-in-cardiomyocyte-differentiation-of-mouse-adipose-tissue-derived-stromal-cells
#5
Chunhui Wang, Wenhui Liu, Xianning Zhang, Yinghui Wang, Huan Liu, Haifang Li
BACKGROUND: We found that mouse brown adipose tissue-derived stromal cells (BATDCs), but not white adipose tissue-derived stromal cells (WATDCs), could spontaneously differentiate into cardiomyocyte-like cells in a simple culture medium. This study would find out some critical trophic factors that were responsible for such difference in differentiation, and further determine the involved signaling pathway. METHODS AND RESULTS: The cardiomyocyte differentiation capacity of cells was identified by morphological observations, immunofluorescence staining, and evaluation of expression of cardiomyocyte specific markers...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27854031/evaluation-of-18-f-fluorothymidine-positron-emission-tomography-18-f-flt-pet-ct-methodology-in-assessing-early-response-to-chemotherapy-in-patients-with-gastro-oesophageal-cancer
#6
R Sharma, P Mapelli, G B Hanna, R Goldin, D Power, A Al-Nahhas, S Merchant, R Ramaswami, A Challapalli, T Barwick, E O Aboagye
BACKGROUND: 3'-Deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) PET has limited utility in abdominal imaging due to high physiological hepatic uptake of a tracer. We evaluated [(18)F]FLT-PET/CT combined with a temporal-intensity information-based voxel-clustering approach termed kinetic spatial filtering (KSF) to improve tumour visualisation in patients with locally advanced and metastatic gastro-oesophageal cancer and as a marker of early response to chemotherapy. Dynamic [(18)F]FLT-PET/CT data were collected before and 3 weeks post first cycle of chemotherapy...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27817059/-18-f-flt-pet-ct-imaging-in-patients-with-advanced-solid-malignancies-treated-with-axitinib-on-an-intermittent-dosing-regimen
#7
Matthew Scarpelli, Justine Yang Bruce, Lakeesha Carmichael, Jens Eickhoff, Jill Kolesar, Scott Perlman, Robert Jeraj, Glenn Liu
PURPOSE: This study utilizes FLT PET/CT imaging to characterize changes in tumor cell proliferation and vasculature during intermittent treatment with VEGR-TKI axitinib. METHODS: Patients with metastatic solid malignancies underwent 3-week treatment cycles with axitinib (7 and 5 mg BID for safety and pharmacodynamic cohorts, respectively). Cycles consisted of 2 weeks of treatment (dosing period) followed by a 1-week treatment break (washout period). Patients in the pharmacodynamic cohort had up to six FLT PET/CT scans (three scans in each cycle 1 and cycle 3) and had plasma VEGF concentrations measured at imaging timepoints...
November 5, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27798786/response-monitoring-with-18-f-flt-pet-and-diffusion-weighted-mri-after-cytotoxic-5-fu-treatment-in-an-experimental-rat-model-for-colorectal-liver-metastases
#8
Sandra Heskamp, Linda Heijmen, Danny Gerrits, Janneke D M Molkenboer-Kuenen, Edwin G W Ter Voert, Kathrin Heinzmann, Davina J Honess, Donna-Michelle Smith, John R Griffiths, Sabrina Doblas, Ralph Sinkus, Peter Laverman, Wim J G Oyen, Arend Heerschap, Otto C Boerman
PURPOSE: The aim of the study was to investigate the potential of diffusion-weighted magnetic resonance imaging (DW-MRI) and 3'-dexoy-3'-[(18)F]fluorothymidine ([(18)F]FLT) positron emission tomography (PET) as early biomarkers of treatment response of 5-fluorouracil (5-FU) in a syngeneic rat model of colorectal cancer liver metastases. PROCEDURES: Wag/Rij rats with intrahepatic syngeneic CC531 tumors were treated with 5-FU (15, 30, or 60 mg/kg in weekly intervals)...
October 31, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27784748/gemcitabine-mechanism-of-action-confounds-early-assessment-of-treatment-response-by-3-deoxy-3-18f-fluorothymidine-in-preclinical-models-of-lung-cancer
#9
Sonja Schelhaas, Annelena Held, Lydia Wachsmuth, Sven Hermann, Davina J Honess, Kathrin Heinzmann, Donna-Michelle Smith, John R Griffiths, Cornelius Faber, Andreas H Jacobs
3'-Deoxy-3'-[(18)F]fluorothymidine positron emission tomography ([(18)F]FLT PET) and diffusion weighted magnetic resonance imaging (DW-MRI) are promising approaches to monitor tumor therapy response. Here, we employed these two imaging modalities to evaluate the response of lung carcinoma xenografts in mice after gemcitabine therapy. Caliper measurements revealed that H1975 xenografts responded to gemcitabine treatment, whereas A549 growth was not affected. In both tumor models uptake of [(18)F]FLT was significantly reduced 6 h after drug administration...
October 26, 2016: Cancer Research
https://www.readbyqxmd.com/read/27784367/-manifestations-of-pet-ct-imaging-in-primary-central-nervous-system-lymphoma
#10
Liang Yin, Zhi-Chun Lin, Jian-Lan Yue, Shi-Ming Huang, Wei Chen
OBJECTIVE: To investigate the PET/CT features of primary central nervous system lymphoma(PCNSL). METHODS: A retrospective analysis of PET/CT imaging manifestations and clinical data was performed in 4 PCNSL cases which were confirmed by surgery or stereotactic pathologic biopsy. RESULTS: The pathologic biopsy in 4 patients all showed diffuse large B cell lymphoma with a total of 8 lesions. All cases were performed with (18)F-FDG PET/CT imaging except 1 patient simultaneously with (18)F-FLT PET/CT imaging in the brain...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27751167/effects-of-capecitabine-treatment-on-the-uptake-of-thymidine-analogs-using-exploratory-pet-imaging-agents-18-f-fau-18-f-fmau-and-18-f-flt
#11
Christopher I McHugh, Jawana M Lawhorn-Crews, Dipenkumar Modi, Kirk A Douglas, Steven K Jones, Thomas J Mangner, Jerry M Collins, Anthony F Shields
BACKGROUND: A principal goal for the use of positron emission tomography (PET) in oncology is for real-time evaluation of tumor response to chemotherapy. Given that many contemporary anti-neoplastic agents function by impairing cellular proliferation, it is of interest to develop imaging modalities to monitor these pathways. Here we examined the effect of capecitabine on the uptake of thymidine analogs used with PET: 3'-deoxy-3'-[(18)F]fluorothymidine ((18)F-FLT), 1-(2'-deoxy-2'-[(18)F]fluoro-β-D-arabinofuranosyl) thymidine ((18)F-FMAU), and 1-(2'-deoxy-2'-[(18)F]fluoro-β-D-arabinofuranosyl) uracil ((18)F-FAU) in patients with advanced cancer...
October 17, 2016: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/27743086/bp-1t-an-antiangiogenic-benzophenone-thiazole-pharmacophore-counteracts-hif-1-signalling-through-p53-mdm2-mediated-hif-1%C3%AE-proteasomal-degradation
#12
Prabhu Thirusangu, V Vigneshwaran, T Prashanth, B R Vijay Avin, Vikas H Malojirao, H Rakesh, Shaukath Ara Khanum, Riaz Mahmood, B T Prabhakar
Hypoxia is a feature of all solid tumours, contributing to tumour progression. Activation of HIF-1α plays a critical role in promoting tumour angiogenesis and metastasis. Since its expression is positively correlated with poor prognosis for cancer patients, HIF-1α is one of the most convincing anticancer targets. BP-1T is a novel antiproliferative agent with promising antiangiogenic effects. In the present study, the molecular mechanism underlying cytotoxic/antiangiogenic effects of BP-1T on tumour/non-tumour angiogenesis was evaluated...
October 14, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27737805/differentiation-of-nerve-derived-adult-pluripotent-stem-cells-into-osteoblastic-and-endothelial-cells
#13
Shang-You Yang, Nora Strong, Xuan Gong, Michael H Heggeness
BACKGROUND: Stem cell-involved tissue engineering has gained dramatic attention as a therapeutic strategy for tissue regeneration including bone repair. However, the currently available possibilities to use embryonic stem cells and induced pluripotent stem cells (iPCs) face potential ethical issues, as well as risks of malignant transformation and immune rejection. Recently identified peripheral nerve-derived adult pluripotent cells (NEDAPS) that quickly proliferate after exposure to BMP-2 or nerve trauma and exhibit many embryonic stem cell characteristics may provide an attractive source cells for a variety of regenerative therapies...
October 10, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27730471/monitoring-tumor-response-after-liposomal-doxorubicin-in-combination-with-liposomal-vinorelbine-treatment-using-3-deoxy-3-18-f-fluorothymidine-pet
#14
Chun-Yi Wu, Jo-Hsin Tang, Pei-Chia Chan, Jia-Je Li, Ming-Hsien Lin, Chih-Chieh Shen, Ren-Shyan Liu, Hsin-Ell Wang
PURPOSE: Surgical resection is the standard treatment for localized colorectal cancer, which is the most common type of gastrointestinal cancer. However, over 40 % cases are diagnosed metastasized and apparently inoperable. Systemic chemotherapy provides an alternative to these patients. This study aims to evaluate the therapeutic potential of liposomal doxorubicin (lipoDox) in combination with liposomal vinorelbine (lipoVNB) in a CT-26 colon carcinoma-bearing mouse model. PROCEDURES: The in vitro cytotoxicity of Dox and VNB on CT-26 cancer cells was determined by MTT and colony formation assays...
October 11, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27729111/vascularization-and-vegf-expression-altered-in-bovine-yolk-sacs-from-ivf-and-nt-technologies
#15
Andrea Maria Mess, Ana Claudia Oliveira Carreira, Cláudia Marinovic de Oliveira, Paula Fratini, Phelipe Oliveira Favaron, Rodrigo da Silva Nunes Barreto, Christiane Pfarrer, Flávio Vieira Meirelles, Maria Angelica Miglino
Reproductive technologies are widely used in cattle, although many are associated with high-embryonic mortality, especially during early gestation, when the yolk sac undergoes macroscopic changes in structure. We hypothesized that vasculogenesis and angiogenesis are affected, thereby affecting embryonic and placental differentiation. To test this, we studied yolk sac development and gene expression of the vascular endothelial growth factor system (VEGF-A, VEGFR-1/Flt-1, VEGFR-2/KDR). Samples from Days 25 to 40/41 of pregnancy from control cattle (n = 8) and from pregnancies established with IVF, (n = 7) or somatic cell nuclear transfer/clones (n = 5) were examined by histology, immunohistochemistry, and quantitative reverse transcriptase PCR...
September 13, 2016: Theriogenology
https://www.readbyqxmd.com/read/27701464/the-positron-emission-tomography-tracer-3-deoxy-3-18f-fluorothymidine-18f-flt-is-not-suitable-to-detect-tissue-proliferation-induced-by-systemic-yersinia-enterocolitica-infection-in-mice
#16
Stefan Wiehr, Anna-Maria Rolle, Philipp Warnke, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Gerald Reischl, Ingo B Autenrieth, Bernd J Pichler, Stella E Autenrieth
Most frequently, gram-negative bacterial infections in humans are caused by Enterobacteriaceae and remain a major challenge in medical diagnostics. We non-invasively imaged moderate and severe systemic Yersinia enterocolitica infections in mice using the positron emission tomography (PET) tracer 3'-deoxy-3'-[18F]fluorothymidine ([18F]FLT), which is a marker of proliferation, and compared the in vivo results to the ex vivo biodistributions, bacterial loads, and histologies of the corresponding organs. Y. enterocolitica infection is detectable with histology using H&E staining and immunohistochemistry for Ki 67...
2016: PloS One
https://www.readbyqxmd.com/read/27694056/copper-64-labeled-liposomes-for-imaging-bone-marrow
#17
Sang-Gyu Lee, Kishore Gangangari, Teja Muralidhar Kalidindi, Blesida Punzalan, Steven M Larson, Naga Vara Kishore Pillarsetty
INTRODUCTION: Bone marrow is the soft tissue compartment inside the bones made up of hematopoietic cells, adipocytes, stromal cells, phagocytic cells, stem cells, and sinusoids. While [(18)F]-FLT has been utilized to image proliferative marrow, to date, there are no reports of particle based positron emission tomography (PET) imaging agents for imaging bone marrow. We have developed copper-64 labeled liposomal formulation that selectively targets bone marrow and therefore serves as an efficient PET probe for imaging bone marrow...
December 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27688473/repeatability-of-18f-flt-pet-in-a-multi-center-study-of-patients-with-high-grade-glioma
#18
Martin A Lodge, Matthias Holdhoff, Jeffrey P Leal, Asim K Bag, L Burt Nabors, Akiva Mintz, Glenn J Lesser, David A Mankoff, Arati S Desai, James M Mountz, Frank S Lieberman, Joy D Fisher, Serena Desideri, Xiaobu Ye, Stuart A Grossman, David Schiff, Richard L Wahl
: Quantitative (18)F-3'-fluoro-3'-deoxy-L-thymidine ((18)F-FLT) positron emission tomography (PET) has potential as a non-invasive tumor biomarker for the objective assessment of response to treatment. To guide interpretation of these quantitative data, we evaluated the repeatability of (18)F-FLT PET as part of a multi-center trial involving patients with high grade glioma. METHODS: (18)F-FLT PET was performed on 10 patients with recurrent high grade glioma at 5 different institutions within the Adult Brain Tumor Consortium trial ABTC1101...
September 29, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27632846/effects-of-a-four-week-biomechanical-ankle-platform-system-protocol-on-balance-in-high-school-athletes-with-chronic-ankle-instability
#19
Mary Spencer Cain, Stacy Watt Garceau, Shelley W Linens
CONTEXT: Chronic Ankle Instability (CAI) describes the residual symptoms present after repetitive ankle sprains. Current rehabilitation programs in the high school population focus on a multi-station approach or general lower extremity injury prevention program. Specific rehabilitation techniques for CAI have not been established. OBJECTIVE: To determine the effectiveness of a 4-week Biomechanical Ankle Platform System (BAPS) Board protocol on balance of high school athletes with CAI...
August 24, 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27621630/effect-of-low-energy-extracorporeal-shock-wave-on-vascular-regeneration-after-spinal-cord-injury-and-the-recovery-of-motor-function
#20
Lei Wang, Yuquan Jiang, Zheng Jiang, Lizhang Han
BACKGROUND: Latest studies show that low-energy extracorporeal shock wave therapy (ESWT) can upregulate levels of vascular endothelial growth factor (VEGF). VEGF can ease nervous tissue harm after spinal cord injury (SCI). This study aims to explore whether low-energy ESWT can promote expression of VEGF, protect nervous tissue after SCI, and improve motor function. METHODS: Ninety adult female rats were divided into the following groups: Group A (simple laminectomy), Group B (laminectomy and low-energy ESWT), Group C (spinal cord injury), and Group D (spinal cord injury and low-energy ESWT)...
2016: Neuropsychiatric Disease and Treatment
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