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https://www.readbyqxmd.com/read/29791046/impact-of-intensive-dosing-of-mycophenolate-on-pancreas-allograft-survival
#1
Jillian L Descourouez, Margaret Jorgenson, Nathan Menninga, Glen Leverson, Jon Odorico, Robert Redfield
PURPOSE: Evaluate the effect of mycophenolate (mycophenolic acid, MPA) dose on pancreas allograft survival following simultaneous pancreas kidney (SPK) transplant. METHODS: This was an observational study of adult SPK recipients transplanted between 1/1/2002-6/30/2015. Recipients were divided into cohorts based on MPA dose at discharge; high dose (HD) 1000mg three times daily mycophenolate mofetil (MMF) and standard dose (SD) 1000mg twice daily MMF. Primary outcome was pancreas allograft survival...
May 23, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29790481/antiviral-combination-therapy-for-cytomegalovirus-infection-in-high-risk-infants
#2
Surabhi B Vora, Adam W Brothers, Alpana Waghmare, Janet A Englund
BACKGROUND: Cytomegalovirus (CMV) infection is a major risk factor for mortality in infants with severe combined immunodeficiency (SCID) and other profound immune defects. Specific antiviral therapy must be initiated early and aggressively because of the potential for antiviral resistance, rapid dissemination and poor transplant outcomes. Combination antiviral therapy is routinely administered for some viral infections, but the value of this approach for the treatment of CMV is unclear...
May 23, 2018: Antiviral Therapy
https://www.readbyqxmd.com/read/29790456/evaluation-of-neuroimaging-findings-of-central-nervous-system-complications-in-heart-transplant-recipients
#3
Hale Turnaoglu, Ahmet Muhtesem Agildere, Feride Kural Rahatli, Fuldem Yildirim Donmez, Ruhsen Ocal, Taner Sezer, Ufuk Can, Atilla Sezgin, Sait Aslamaci
OBJECTIVES: In this study, we presented neuroradiologic findings and diagnoses of neurologic complications in a series of heart transplant recipients. MATERIALS AND METHODS: A retrospective review was conducted at Başkent University Hospital. We searched the hospital and radiology databases and identified 109 heart transplant recipients. Thirty-one of these recipients had neuroradiologic evaluations secondary to presentation of neurologic symptoms after heart transplant, with 18 patients evaluated with computed tomography and 22 patients evaluated with magnetic resonance imaging (overlap of imaging-defined groups occurred in 9 recipients)...
May 23, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29790455/successful-management-of-de-novo-acute-hepatitis-b-virus-infection-with-entecavir-in-a-living-donor-liver-transplant-patient
#4
Sami Akbulut, Murat Harputluoglu, Sezai Yilmaz
The risk of de novo hepatitis B virus infection is lower after liver transplant using hepatitis B core antibody-negative donors into negative recipients versus hepatitis B core antibody-positive donors but can occur. Here, we present a 34-year-old male patient with acute de novo hepatitis B virus that developed 7 months after successful liver transplant. The case we report here is the first in the literature with regard to both switch from tenofovir to entecavir treatment and the presentation of de novo acute hepatitis B virus after liver transplant...
May 23, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29790292/failure-of-voriconazole-therapy-due-to-acquired-azole-resistance-in-aspergillus-fumigatus-in-a-kidney-transplant-recipient-with-chronic-necrotizing-aspergillosis
#5
Benoit Pilmis, Dea Garcia-Hermoso, Alexandre Alanio, Emilie Catherinot, Anne Scemla, Vincent Jullien, Stéphane Bretagne, Olivier Lortholary
Invasive aspergillosis (IA) affects lungs and disseminates mostly in patients with neutropenia and/or receiving immunosuppressive and steroid therapies. Despite progress in diagnosis and therapy of IA, it is still characterized by a high mortality rate. Currently, voriconazole is considered as the standard therapy for invasive aspergillosis. Over the recent years, triazole resistant Aspergillus fumigatus isolates have emerged in the environment due to the use of fungicidal agricultural products with the risk of developing IA related to a resistant isolate...
May 22, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29789960/cutaneous-manifestations-of-infections-in-solid-organ-transplant-recipients
#6
REVIEW
Cory J Pettit, Katherine Mazurek, Benjamin Kaffenberger
PURPOSE OF REVIEW: Post-transplant infections present a formidable challenge to the physician due to their varied presentation. Many of these infections begin by inoculation following skin compromise or disseminate to the skin hematogenously, making cutaneous manifestations of infection an important diagnostic clue in the immunocompromised. Quality research in this field is lacking, and this articles seeks to review the literature and present a guide to physicians in order for them to suspect certain infections by their cutaneous presentation...
May 22, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29789956/hepatitis-c-current-controversies-and-future-potential-in-solid-organ-transplantation
#7
REVIEW
Lucy Somerville, Karen Doucette
PURPOSE OF REVIEW: To highlight the changing landscape of hepatitis C virus (HCV) infection in the context of organ transplantation. This focuses on areas of controversy and future potential in the era of highly effective direct-acting antiviral (DAA) agents. RECENT FINDINGS: Since the advent of safe and highly effective DAA therapy, HCV infection is now curable in virtually all cases, including organ transplant recipients. Excellent drug tolerability and safety combined with high cure rates across all organ groups means that HCV is no longer a barrier to transplantation or its outcomes...
May 22, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29789006/outcomes-of-lung-transplantation-in-adults-with-bronchiectasis
#8
Jodie Birch, Syba S Sunny, Katy L M Hester, Gareth Parry, F Kate Gould, John H Dark, Stephen C Clark, Gerard Meachery, James Lordan, Andrew J Fisher, Paul A Corris, Anthony De Soyza
BACKGROUND: Lung transplantation is a well-established treatment for end-stage non-cystic fibrosis bronchiectasis (BR), though information regarding outcomes of transplantation remains limited. Our results of lung transplantation for Br are reported here. METHODS: A retrospective review of case notes and transplantation databases was conducted for patients that had underwent lung transplantation for bronchiectasis at the Freeman Hospital between 1990 and 2013. RESULTS: Fourty two BR patients underwent lung transplantation, the majority (39) having bilateral sequential lung transplantation...
May 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29788939/nontuberculous-mycobacteria-infection-and-lung-transplantation-in-cystic-fibrosis-a-worldwide-survey-of-clinical-practice
#9
Adrien Tissot, Matthew F Thomas, Paul A Corris, Malcolm Brodlie
BACKGROUND: In people with cystic fibrosis infection with NonTuberculous Mycobacteria is of increasing prevalence. Mycobacterium abscessus complex is of particular concern and has been associated with adverse clinical outcomes. Optimal treatment usually requires multiple antibiotics for over 12 months. When considering lung transplantation for patients with NonTuberculous Mycobacteria potential benefits must be balanced against the risks of uncontrolled infection post-transplant and significant side-effects associated with treatment...
May 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29788730/afp-role-in-predicting-recurrence-of-hepatocellular-carcinoma-after-living-donor-liver-transplantation-in-hcv-patients
#10
A Lech Komorowski, C C Hsu, K D Julka, B Vasavada, C C Lin, C C Wang, C L Chen
HCC is one of the leading causes of death worldwide. Liver transplantation including living donor transplantation is the best available treatment. We have analyzed our experience with LDLT in patients with HCC and HCV in order to determine if alpha feto-protein (AFP) is a better predictor of recurrence than the tumor burden. We have identified all patients with HCV related liver disease and HCC who have undergone LDLT in one center during the period from December 2000 to December 2014. Outcomes from the prospective database were compared for patients who met Milan criteria (single tumor ≤5 cm, maximum of 3 total tumors with none >3 cm) or not...
March 14, 2018: Neoplasma
https://www.readbyqxmd.com/read/29788538/hepatitis-e-virus-in-south-america-the-current-scenario
#11
María Belén Pisano, Maribel Martínez Wassaf, Santiago Mirazo, Anabella Fantilli, Juan Arbiza, José Debes, Viviana E Ré
Hepatitis E virus (HEV) is one of the most frequent causes of acute viral hepatitis of enteric transmission worldwide. In South America the overall epidemiology has been little studied, and the burden of the disease remains largely unknown. A research of all scientific articles about HEV circulation in South America until November 2017 was carried out. Human seroprevalences of HEV varied according to the studied population: blood donors presented prevalence rates ranging from 1.8 to 9.8%, while reports from HIV-infected individuals, transplant recipients and patients on hemodialysis showed higher prevalence rates...
May 22, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29788474/umbilical-cord-blood-transplantation-corrects-very-early-onset-inflammatory-bowel-disease-in-chinese-patients-with-il10ra-associated-immune-deficiency
#12
Kaiyue Peng, Xiaowen Qian, Zhiheng Huang, Junping Lu, Yuhuan Wang, Ying Zhou, Huijun Wang, Bingbing Wu, Ying Wang, Lingli Chen, Xiaowen Zhai, Ying Huang
Background: Hematopoietic stem cell transplantation is considered the only curative therapy for very early-onset inflammatory bowel disease with specific immune defects, such as interleukin-10 receptor deficiency. We performed reduced-intensity conditioning before umbilical cord blood transplantation in patients with interleukin-10 receptor-A deficiency. Methods: We enrolled 9 very early-onset inflammatory bowel disease patients with typical manifestations. We diagnosed the patients with interleukin-10 receptor-A deficiency by whole-exome sequencing...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29787887/human-pegivirus-persistence-in-the-human-blood-virome-after-allogeneic-haematopoietic-stem-cell-transplantation
#13
Diem-Lan Vu, Samuel Cordey, Federico Simonetta, Francisco Brito, Mylène Docquier, Lara Turin, Christian van Delden, Elsa Boely, Carole Dantin, Amandine Pradier, Eddy Roosnek, Yves Chalandon, Evgeny M Zdobnov, Stavroula Masouridi-Levrat, Laurent Kaiser
OBJECTIVES: As commensal viruses are defined by the immunological tolerance afforded to them, any immunomodulation, such as is received during haematopoietic stem cell transplantation, may shift the demarcation between innocuous viral resident and disease-causing pathogen. METHODS: We analysed by deep-sequencing the plasma virome of 40 allogeneic haematopoietic stem cell transplant (allo-HSCT) patients 1 month post-transplantation. As human pegivirus (HPgV) was highly prevalent, we performed a one-year screening of 122 plasma samples by specific rRT-PCR assay...
May 19, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29786579/operative-treatment-of-corrosive-esophageal-strictures
#14
Volodymyr O Shaprynskyi, Yevhen V Shaprynskyi, Yaroslav V Karyi, Serhii A Lysenko, Oleg O Vorovskyi, Andrii I Semenenko
OBJECTIVE: Introduction: Nowadays operative treatment of corrosive esophageal strictures remains one of the difficult and unsolved problems in surgery. The level of postoperative complications such as anastomotic leak (develops in 7-30% of cases), infections, pneumonia, pleural empyema, mediastinitis, peritonitis, postoperative corrosive strictures is still rather high. The aim of our work was to improve the results of surgical treatment of patients with corrosive esophageal strictures by analyzing and refining on conservative therapy options as well as differentiated approach to each operative treatment method...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29785692/impact-of-enteral-nutrition-with-an-immunomodulating-diet-enriched-with-hydrolyzed-whey-peptide-on-infection-after-liver-transplantation
#15
Naoko Kamo, Toshimi Kaido, Yuhei Hamaguchi, Ryuji Uozumi, Shinya Okumura, Atsushi Kobayashi, Hisaya Shirai, Shintaro Yagi, Hideaki Okajima, Shinji Uemoto
BACKGROUND: Infection is a leading cause of death after liver transplantation (LT). Therefore, prevention of infection is crucial for improving outcomes after LT. We examined the impact of early enteral nutrition with an immunomodulating diet (IMD) enriched with hydrolyzed whey peptide (HWP) formulation on infection after living donor LT (LDLT), focusing on sarcopenia. METHODS: This study enrolled 279 consecutive patients who underwent primary LDLT at our institute between January 2008 and April 2015...
May 21, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29785139/blockage-of-store-operated-ca-2-entry-antagonizes-epstein-barr-virus-promoted-angiogenesis-by-inhibiting-ca-2-signaling-regulated-vegf-production-in-nasopharyngeal-carcinoma
#16
Jiaxiang Ye, Junqi Huang, Qian He, Weilin Zhao, Xiaoying Zhou, Zhe Zhang, Yongqiang Li, Jiazhang Wei, Jinyan Zhang
Background: Epstein-Barr virus (EBV) actively contributes to the pathological process of nasopharyngeal carcinoma (NPC) by enabling NPC cells to acquire various capacities required for their malignant biological actions. Our earlier works demonstrated that EBV-encoded latent membrane protein 1 (LMP1) enhanced vascular endothelial growth factor (VEGF)-mediated angiogenesis by boosting store-operated Ca2+ entry (SOCE) upon extracellular epidermal growth factor (EGF) stimulation. However, the antagonistic effects of SOCE blockage on EBV-promoted angiogenesis must be appropriately evaluated in vivo, and the global effect of EBV infection on the EGF-elicited cytosolic Ca2+ signaling, which regulates VEGF-mediated angiogenesis remains to be further clarified...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29785131/epidemiology-susceptibility-and-risk-factors-for-acquisition-of-mdr-xdr-gram-negative-bacteria-among-kidney-transplant-recipients-with-urinary-tract-infections
#17
Xiuhong Yuan, Taohua Liu, Di Wu, Qiquan Wan
Background: Multiple drug resistant/extensively drug resistant (MDR/XDR) Gram-negative urinary tract infections (UTIs) represent a growing threat to kidney transplant recipients. This retrospective study aimed to assess the incidence and microbiological profile of MDR/XDR Gram-negative UTIs, to identify drug susceptibility of MDR/XDR bacteria, and to determine the potential risk factors for MDR/XDR UTIs in kidney recipients. Materials and methods: During the study period, 1569 patients underwent consecutive kidney transplantation in two transplantation centers...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29785130/human-herpesvirus-6-pneumonitis-in-a-patient-with-follicular-lymphoma-following-immunochemotherapy-with-rituximab
#18
Saeko Kuwahara-Ota, Yoshiaki Chinen, Yoshimi Mizuno, Tomoko Takimoto-Shimomura, Yayoi Matsumura-Kimoto, Kazuna Tanba, Taku Tsukamoto, Shinsuke Mizutani, Yuji Shimura, Tsutomu Kobayashi, Shigeo Horiike, Junya Kuroda
Primary infection with human herpesvirus-6 (HHV-6) commonly occurs at an early age in children, most often at 3 years of age, and is associated with childhood diseases, such as exanthema subitum, hepatitis, febrile convulsions, or encephalitis. However, the virus occasionally reactivates from its latent state in immunosuppressed adults, especially post-transplant, resulting in serious disseminated, sometimes life-threatening end-organ complications. Herein, we report a case of a 68-year-old man with relapsed follicular lymphoma who developed HHV-6 pneumonitis...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29784907/a-predictive-model-for-risk-of-early-grade-%C3%A2-3-infection-in-patients-with-multiple-myeloma-not-eligible-for-transplant-analysis-of-the-first-trial
#19
Charles Dumontet, Cyrille Hulin, Meletios A Dimopoulos, Andrew Belch, Angela Dispenzieri, Heinz Ludwig, Philippe Rodon, Jan Van Droogenbroeck, Lugui Qiu, Michele Cavo, Ann Van de Velde, Juan José Lahuerta, Olivier Allangba, Jae Hoon Lee, Eileen Boyle, Aurore Perrot, Philippe Moreau, Salomon Manier, Michel Attal, Murielle Roussel, Mohamad Mohty, Jean Yves Mary, Alexandre Civet, Bruno Costa, Antoine Tinel, Yann Gaston-Mathé, Thierry Facon
Infections are a major cause of death in patients with multiple myeloma. A post hoc analysis of the phase 3 FIRST trial was conducted to characterize treatment-emergent (TE) infections and study risk factors for TE grade ≥ 3 infection. The number of TE infections/month was highest during the first 4 months of treatment (defined as early infection). Of 1613 treated patients, 340 (21.1%) experienced TE grade ≥ 3 infections in the first 18 months and 56.2% of these patients experienced their first grade ≥ 3 infection in the first 4 months...
April 26, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29783907/association-between-potential-drug-interactions-and-clinical-outcomes-in-hematopoietic-stem-cell-transplantations
#20
Ingrid Apm Valverde, Mario Js da Silva, Maely Pf Retto
The association of anti-infective, antineoplastic and immunosuppressant drugs makes patients undergoing hematopoietic stem cell transplantation susceptible to the effects resulting from drug interactions. In this study, we analyzed the potential drug interactions in the association between anti-infective, antineoplastic and immunomodulators agents and their clinical effects presented by patients from a bone marrow transplant service of a Brazilian hospital specialized in cancer treatment. The retrospective cohort involved patients in the conditioning phase undergoing transplantation in the year 2013...
January 1, 2018: Journal of Oncology Pharmacy Practice
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