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https://www.readbyqxmd.com/read/28544959/effect-of-different-mineralization-processes-on-in-vitro-and-in-vivo-bone-regeneration-and-osteoblast-macrophage-cross-talk-in-co-culture-system-using-dual-growth-factor-mediated-non-mulberry-silk-fibroin-grafted-poly-%C3%B0-caprolactone-nanofibrous-scaffold
#1
Promita Bhattacharjee, Tapas K Maiti, Debasis Bhattacharya, Samit Kumar Nandi
This study evaluates mineralized nanofibrous polymeric scaffolds at supporting in vitro osteogenic differentiation of human mesenchymal stem cells (hMSCs) and in vivo bone tissue regeneration. Co-electrospin, alternative soaking, and electrodeposition were used to introduce hydroxyapatite in non-mulberry silk fibroin grafted poly(Є-caprolactone) nanofibrous scaffolds. Bone morphogenic protein-2 and Transforming growth factor-β, at a potency ratio of 1:1, are covalently coupled onto the scaffolds. hMSCs proliferation and interactions are studied through MTT and Alamar blue assay and scanning electron and confocal microscopy...
May 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28544807/effects-of-teriparatide-on-joint-erosions-in-rheumatoid-arthritis-a-randomized-controlled-trial
#2
D H Solomon, J Kay, J Duryea, B Lu, M B Bolster, R A Yood, R Han, S Ball, C Coleman, E Lo, A Wohlfahrt, M Sury, M Yin, Z Yu, A Zak, E M Gravallese
BACKGROUND: Articular erosions correlate with disability in rheumatoid arthritis (RA). Biologic treatments for RA reduce erosion progression, but erosion healing occurs infrequently. The goal of this study was to assess the effects of the anabolic agent teriparatide on joint erosion volume in RA patients treated with a tumor necrosis factor inhibitor (TNFi). METHODS: We conducted a randomized controlled trial in 24 patients with erosive RA, osteopenia, and disease activity controlled on a TNFi for at least three months...
May 23, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28544667/effect-of-the-long-term-administration-of-cyclosporine-a-on-bone-healing-around-osseointegrated-titanium-implants-a-histomorphometric-study-in-the-rabbit-tibia
#3
Rafael Scaf de Molon, Celso Eduardo Sakakura, Rafael Silveira Faeda, Rafael Sartori, Daniel Palhares, Rogerio Margonar, Elcio Marcantonio
The aim of this study was to investigate the effect of cyclosporine A (CsA) therapy on bone healing around osseointegrated implants in the rabbit by means of descriptive histologic and histomorphometric analyses. Eighteen rabbits received one implant each in the right tibia proximal metaphysis. After the bone-healing period of 3 months, 6 randomly selected animals were sacrificed (Group CTL-12) before the immunosuppression therapy initiation to obtain a standard of implant integration. Another six randomly selected animals were submitted to a daily subcutaneous (sc) injection of 10 mg/kg CsA (Group CsA) whereas the six remaining animals received daily sc injections of saline solution (Group CTL-24)...
May 22, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28544215/anterior-single-implants-with-different-neck-designs-5-year-results-of-a-randomized-clinical-trial
#4
Laurens den Hartog, Henny J A Meijer, Arjan Vissink, Gerry M Raghoebar
BACKGROUND: The design of the implant neck might be significant for preservation of marginal bone. PURPOSE: To compare the 5-year radiographic and clinical outcome of single anterior implants provided with a smooth neck, a rough neck or a scalloped rough neck. MATERIALS AND METHODS: 93 Patients with a missing anterior tooth in the maxilla were included. At random, patients received an implant with a 1.5 mm smooth neck ("smooth group"), a rough neck with grooves ("rough group") or a scalloped rough neck with grooves ("scalloped group")...
May 23, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28543806/effect-of-microthreads-on-coronal-bone-healing-of-narrow-diameter-implants-with-reverse-tapered-design-in-beagle-dogs
#5
Yun-Young Chang, Su-Hwan Kim, Keun-Oh Park, Jeong-Ho Yun
OBJECTIVES: The objective of this study was to investigate the effect of microthreads on the coronal bone healing of narrow-diameter implants with reverse-tapered design. MATERIAL AND METHODS: A total of 52 implants were classified into two groups according to presence or absence of coronal microthreads, the reverse-tapered narrow-diameter implant (RTN) group, and the reverse-tapered narrow-diameter implant with microthreads (RTNM) group. The implants were installed in split-mouth design in the edentulous mandible of six dogs...
May 22, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28541269/immediate-loading-of-tantalum-based-implants-in-fresh-extraction-sockets-in-patient-with-sjogren-syndrome-a-case-report-and-literature-review
#6
Cristian Peron, Fawad Javed, Georgios E Romanos
PURPOSE: The objective of this article is to demonstrate treatment of a clinical case using implants in conjunction with immediate loading in a patient with Sjogren syndrome (SS) and to present the current status of knowledge about this type of patients with dental implants. MATERIALS AND METHODS: This article describes a 62-year-old woman patient with SS and partially edentulous maxilla who was rehabilitated with 5 immediately loaded tantalum-based dental implants (TBDIs) placed in fresh extraction sockets...
May 22, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28541092/amniotic-mesenchymal-stromal-cells-exhibit-preferential-osteogenic-and-chondrogenic-differentiation-and-enhanced-matrix-production-compared-with-adipose-mesenchymal-stromal-cells
#7
Natasha Topoluk, Richard Hawkins, John Tokish, Jeremy Mercuri
BACKGROUND: Therapeutic efficacy of various mesenchymal stromal cell (MSC) types for orthopaedic applications is currently being investigated. While the concept of MSC therapy is well grounded in the basic science of healing and regeneration, little is known about individual MSC populations in terms of their propensity to promote the repair and/or regeneration of specific musculoskeletal tissues. Two promising MSC sources, adipose and amnion, have each demonstrated differentiation and extracellular matrix (ECM) production in the setting of musculoskeletal tissue regeneration...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28540568/-tibial-pilon-fractures-advoidance-and-therapy-of-complications
#8
REVIEW
Ralph Gaulke, Christian Krettek
Because of the complex fracture morphology and vulnerable soft tissue coverage, fractures of the tibial pilon are difficult to treat. Complications are more common than in bi- or trimalleolar fractures. The surgeon has to know about the special risks of these injuries to avoid complications. Early complications are soft tissue necrosis, persisting fragment dislocations after surgery, loss of reposition and deep wound infection. The surgeon has to be aware of early signs of compartment-syndrome and chronic regional pain syndrome (CRPS)...
May 24, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28540528/sema3a-promotes-the-resolution-of-cardiac-inflammation-after-myocardial-infarction
#9
Marieke Rienks, Paolo Carai, Nicole Bitsch, Mark Schellings, Maarten Vanhaverbeke, Johan Verjans, Ilona Cuijpers, Stephane Heymans, Anna Papageorgiou
Optimal healing after myocardial infarction requires not only the induction of inflammation, but also its timely resolution. In patients, 30 days post myocardial infarction, circulating monocytes have increased expression of Semaphorin3A (Sema3A) as compared to directly after admission. This increased expression coincides with increased expression of Cx3CR1-a marker of non-classical monocytes that are important for immune resolution hence proper wound healing. In mice, the expression of Sema3A also increases in response to myocardial ischemia being expressed by infiltrating leukocytes...
July 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28540414/bone-substitutes-in-adolescent-idiopathic-scoliosis-surgery-using-sublaminar-bands-is-it-useful-a-case-control-study
#10
Sebastien Pesenti, Soufiane Ghailane, Jeffrey J Varghese, Matthieu Ollivier, Emilie Peltier, Elie Choufani, Gerard Bollini, Benjamin Blondel, Jean-Luc Jouve
INTRODUCTION: In order to avoid pseudarthrosis in adolescent idiopathic (AIS) patients, it is recommended to bring additional bone graft or substitute. Modern rigid instrumentations have been shown to provide less pseudarthroses even without bone substitutes. The aim of our study was to determine the impact of using bones substitutes on fusion rates in adolescent idiopathic scoliosis patients undergoing PSF with sublaminar bands. METHOD: AIS patients scheduled to undergo PSF with sublaminar bands were prospectively enrolled into this study and not given any bone substitutes (no-substitute group)...
May 24, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28538564/discussion-combining-smoothened-agonist-and-nel-like-protein-1-enhances-bone-healing
#11
Ryan C Ransom, Michael T Longaker
No abstract text is available yet for this article.
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28538459/patient-comprehension-and-compliance-survey-to-assess-postoperative-pain-regimens-in-the-orthopaedic-trauma-population
#12
Anup K Gangavalli, Ajith Malige, Saqib Rehman, Chinenye O Nwachuku
OBJECTIVE: This study aims to determine the groups of patients who are at risk for noncompliance and misunderstanding of their pain regimen. DESIGN: Survey-based cohort study. SETTING: Suburban Level-I trauma center. PATIENTS/PARTICIPANTS: A total of 171 patients between the ages of 18-89 years who underwent surgical fixation of fractures involving the pelvis, long bones, or periarticular regions of the knee, ankle, elbow, and wrist...
June 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28538076/regeneration-of-cystic-bone-cavities-and-bone-defects-with-bioactive-glass-s53p4-in-the-upper-and-lower-jaws
#13
Patricia Stoor, Satu Apajalahti, Risto Kontio
Cysts and tumors are common lesions in the jaws. To be able to retain a good volume of the alveolar ridge during healing as well as strengthening the angle and body of the mandible and provide an instant improved support for adjacent teeth, reliable long-term bone regeneration is needed. The purpose of this prospective study was to promote bone regeneration by filling bony defects in the upper or lower jaw with granules of the bioactive glass S53P4 (BAG), which have osteostimulative and antimicrobial properties...
May 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28538066/radial-forearm-osteocutaneous-free-flap-for-reconstruction-of-hard-palate-with-alveolar-defect
#14
Euicheol C Jeong, Sehoon Yoon, Young Ho Jung
The radial forearm free flap is beneficial for reconstruction of large palatal defect with oronasal fistula.A 51-year-old male patient who had anterior palate defect including alveolus after the radiation therapy of malignant cancer on the nasopharyngeal area undertook the radial forearm osteocutaneous free flap to close the oronasal fisula and restore the alveolar arch. The small radial bone segment was fixed in the alveolar defect and vascular anastomoses were performed with facial vessels in neck. The donor site was closed with split thickness skin graft...
May 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28537650/tendon-healing-induced-by-chemically-modified-mrnas
#15
K Groth, T Berezhanskyy, M K Aneja, J Geiger, M Schweizer, L Maucksch, T Pasewald, T Brill, B Tigani, E Weber, C Rudolph, G Hasenpusch
Tendon disorders are frequent both in human and veterinary medicine with high re-injury rates and unsatisfactory therapeutic treatments. Application of naked, chemically-modified mRNA (cmRNA), encoding for therapeutic proteins, is an innovative approach to address tendon healing. In the current study, we demonstrated that injection of naked cmRNA, diluted in a glucose-containing solution, into tendons resulted in high protein expression in healthy and experimentally-injured tendons. Injection of bone morphogenetic protein 7 (BMP-7)-encoding cmRNA resulted in a significantly higher expression of BMP-7 protein and reduced formation of collagen type III, compared to vehicle control...
May 24, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28537529/a-versatile-protocol-for-studying-calvarial-bone-defect-healing-in-a-mouse-model
#16
Rebekah Margaret Samsonraj, Amel Dudakovic, Pengfei Zan, Oksana Pichurin, Simon Cool, Andre J van Wijnen
Animal models are vital tools for the preclinical development and testing of therapies aimed at providing solutions for several musculoskeletal disorders. For bone tissue engineering strategies addressing non-union conditions, rodent models are particularly useful for studying bone healing in a controlled environment. The mouse calvarial defect model permits evaluation of drug, growth factor or cell transplantation efficacy, together with offering the benefit of utilizing genetic models to study intramembranous bone formation within defect sites...
May 24, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28537107/clinical-and-audiological-short-term-and-long-term-outcomes-of-fat-graft-myringoplasty
#17
Johan Knutsson, Annika Kahlin, Magnus von Unge
INTRODUCTION: Results of fat graft myringoplasty are often reported with only short-term follow-up. Audiological results are less commonly reported, as well as long-term follow-up results. MATERIALS AND METHODS: One hundred consecutive patients scheduled for fat graft myringoplasty were included in a prospective cohort study. Clinical and audiological outcomes were assessed at six weeks and one year postoperatively. RESULTS: Perforation sizes ranged from 0...
May 24, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28536801/induced-membrane-technique-using-beta-tricalcium-phosphate-for-reconstruction-of-femoral-and-tibial-segmental-bone-loss-due-to-infection-technical-tips-and-preliminary-clinical-results
#18
Gen Sasaki, Yoshinobu Watanabe, Wataru Miyamoto, Youichi Yasui, Shota Morimoto, Hirotaka Kawano
PURPOSE: This study aimed to provide preliminary evidence regarding effectiveness of grafting beta-tricalcium phosphate (β-TCP) combined with a cancellous autograft for treating nonunion of long bones in the lower extremity due to infection by evaluating clinical and radiological outcomes. METHODS: We retrospectively reviewed the clinical and radiological results in seven patients (six men, one woman; median age 39 years) treated by the induced membrane technique for nonunion of the femur or tibia due to infection...
May 24, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28535616/drug-induced-osteonecrosis-of-the-jaw-the-state-of-the-art
#19
A Fassio, F Bertoldo, L Idolazzi, O Viapiana, M Rossini, D Gatti
Osteonecrosis of the jaw (ONJ) is a rare adverse event of antiresorptive drugs such as bisphosphonates (BP) and denosumab (DMAb). The diagnosis of ONJ is considered in cases where exposed bone in the maxillofacial region does not heal within 8 weeks in a patient previously treated with an antiresorptive agent. In patients with osteoporosis, ONJ is reported as a very rare adverse event while in oncologic patients with bone metastases or malignant hypercalcemia the incidence is significantly higher (up to the 1-10% of the patients)...
May 22, 2017: Reumatismo
https://www.readbyqxmd.com/read/28534951/contribution-of-methylglyoxal-to-delayed-healing-of-bone-injury-in-diabetes
#20
Takao Aikawa, Hidenori Matsubara, Shuhei Ugaji, Junichi Shirakawa, Ryoji Nagai, Seiichi Munesue, Ai Harashima, Yasuhiko Yamamoto, Hiroyuki Tsuchiya
Patients with diabetes are vulnerable to delayed bone fracture healing or pseudoarthrosis. Chronic sustained hyperglycemia, reactive intermediate derivatives of glucose metabolism, such as methylglyoxal (MGO), and advanced glycation end‑products (AGEs) are implicated in diabetic complications. In the present study, it was examined whether MGO is able to cause disturbed bone healing in diabetes. Diabetes was induced in male mice by injection of streptozotocin (50 mg/kg) for 5 days. A bone defect (1.0‑mm diameter) was created in the left distal femur, and bone repair was assessed from an examination of computed tomography scans...
May 16, 2017: Molecular Medicine Reports
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