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https://www.readbyqxmd.com/read/29909597/recent-advances-and-future-of-gene-therapy-for-bone-regeneration
#1
REVIEW
Galina Shapiro, Raphael Lieber, Dan Gazit, Gadi Pelled
PURPOSE OF REVIEW: The purpose of this review is to discuss the recent advances in gene therapy as a treatment for bone regeneration. While most fractures heal spontaneously, patients who present with fracture nonunion suffer from prolonged pain, disability, and often require additional operations to regain musculoskeletal function. RECENT FINDINGS: In the last few years, BMP gene delivery by means of electroporation and sonoporation resulted in repair of nonunion bone defects in mice, rats, and minipigs...
June 16, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29908343/promoting-in-vivo-early-angiogenesis-with-sub-micrometer-strontium-contained-bioactive-microspheres-through-modulating-macrophage-phenotypes
#2
Fujian Zhao, Bo Lei, Xian Li, Yunfei Mo, Renxian Wang, Dafu Chen, Xiaofeng Chen
Early vascularization capacity of biomaterials plays an essential role in efficient wound healing and tissue regeneration, especially in large tissue tension implanting position such as bone augmentation. Strontium-contained silica-based bioactive materials have shown the role of promoting angiogenesis by stimulating osteoblasts to secrete angiogenesis related cytokines. However, osteoblasts have little effect on early angiogenesis due to the inflammatory reaction of implantation site. Here, for the first time, we found that the monodispersed strontium-contained bioactive glasses microspheres (SrBGM) could significantly promote the early angiogenesis through regulating macrophage phenotypes...
June 8, 2018: Biomaterials
https://www.readbyqxmd.com/read/29908007/cocl-2-a-mimic-of-hypoxia-enhances-bone-marrow-mesenchymal-stem-cells-migration-and-osteogenic-differentiation-via-stat3-signaling-pathway
#3
Xin Yu, Qilong Wan, Gu Cheng, Xin Cheng, Jing Zhang, Janak L Pathak, Zubing Li
Mesenchymal stem cells homing and migration is a crucial step during bone fracture healing. Hypoxic environment in fracture site induces bone marrow mesenchymal stem cells (BMSCs) migration, but its mechanism remains unclear. Our previous study and studies by other groups have reported the involvement of signal transducer and activator of transcription 3 (STAT3) pathway in cell migration. However, the role of STAT3 pathway in hypoxia-induced cell migration is still unknown. In this study, we investigated the role of STAT3 signaling in hypoxia-induced BMSCs migration and osteogenic differentiation...
June 16, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29907373/effect-of-trochleocapitellar-index-on-adult-patient-reported-outcomes-after-noncomminuted-intra-articular-distal-humeral-fractures
#4
Giuseppe Rollo, Roberto Rotini, Denise Eygendaal, Paolo Pichierri, Michele Bisaccia, Ante Prkic, Alessandro Stasi, Luigi Meccariello
BACKGROUND: Anatomic surgical reduction of intra-articular fractures of the distal humerus is important to achieve the best long-term outcomes and prevent post-traumatic arthritis. In this study we compared the radiographic reduction using the trochleocapitellar index. We also correlated the trochleocapitellar index to the functional outcomes next to the comparison of the triceps brachii lifting approach and olecranon osteotomy approach, 2 common approaches for distal humeral fractures...
July 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29905526/similar-function-and-complications-for-patients-with-short-versus-long-hip-nailing-for-unstable-pertrochanteric-fractures
#5
Ioannis P Galanopoulos, Andreas F Mavrogenis, Panayiotis D Megaloikonomos, Christos T Vottis, Evanthia Mitsiokapa, Panayiotis Koulouvaris, Dimitrios S Mastrokalos, Panayiotis J Papagelopoulos, Vasilios A Kontogeorgakos
PURPOSE: To compare short with long intramedullary hip nailing for elderly patients with unstable pertrochanteric fractures. METHODS: We prospectively studied 50 patients (33 women, 17 men; mean age, 80 years; range, 74-93 years) with unstable pertrochanteric fractures admitted and treated with a short (group A) or a long (group B) intramedullary hip nail from January 2013 to 2017. The patients were randomly allocated into each group according to their order of admission...
2018: SICOT-J
https://www.readbyqxmd.com/read/29905051/-new-type-of-sutured-titanium-wire-combined-with-titanium-nail-internal-fixation-for-correction-of-serious-old-medial-canthus-deformity
#6
Ying Zhang, Changhong Zeng, Jun Chen, Bo Guo
Objective: To evaluate the effectiveness of a new type of sutured titanium wire combined with titanium nail internal fixation in correction of serious old medial canthus deformity. Methods: Between March 2012 and June 2015, 18 patients with unilateral serious old medial canthus deformity were treated. There were 14 males and 4 females. The patient's age ranged from 23 to 62 years (mean, 42 years). The causes of deformity included accident injury in 10 cases, boxing injury in 4 cases, sharp device scratching in 3 cases, and animal bite in 1 case...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29902595/cigarette-smoke-increases-pro-inflammatory-markers-and-inhibits-osteogenic-differentiation-in-experimental-exposure-model
#7
G N Cyprus, J W Overlin, K M Hotchkiss, S Kandalam, R Olivares-Navarrete
Tobacco smokers have slowed bone growth and regeneration and more frequent implant failures than non-smokers, but the effect of cigarette smoking on the host response to bone-dwelling biomaterials is poorly understood. Macrophages and mesenchymal stem cells (MSCs) are essential in the healing response after implant placement. This study examined the effects of an experimental model of cigarette smoke exposure using cigarette smoke extract (CSE) on bone architecture in vivo and differentiation and inflammatory cytokine production on clinically relevant microstructured surfaces in vitro...
June 11, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29902525/propolis-extract-a-new-reinforcement-material-in-improving-bone-healing-an-in-vivo-study
#8
Abdolhamid Meimandi-Parizi, Ahmad Oryan, Emad Sayahi, Amin Bigham-Sadegh
BACKGROUND: propolis is known for its antioxidant, immune response modulating, and wound healing effects. In the present study in order to determine the bone healing capacity of the propolis extract, a critical sized, nonunion, radial bone defect model was repaired in rat, using chitosan and demineralized bone matrix (DBM) scaffolds along with propolis extract. MATERIALS AND METHODS: Seventy-two radial bone defects in 36 healthy male rats were randomly divided into 6 groups (n= 12/group)...
June 11, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29902161/curcumin-promotes-femoral-fracture-healing-in-a-rat-model-by-activation-of-autophagy
#9
Gang Li, Lei Chen, Kai Chen
BACKGROUND The aim of this study was to use a rat model of femoral fracture healing to study the effects of curcumin on cell autophagy, compared with treatment with 3-methyladenine (3-MA), an inhibitor of autophagy. MATERIAL AND METHODS Thirty-six Sprague-Dawley rats with right mid-femoral fracture were divided into three groups: the curcumin-treated group (N=12) (gavage with curcumin 400 mg/kg/day); the curcumin + 3-MA-treated group (gavage with curcumin 400 mg/kg/day + 3-MA 30 mg/kg/day); and the control group (N=12) (gavage normal saline)...
June 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29901481/reverse-reamed-intercalary-allograft-a-surgical-technique
#10
Benjamin Wilke, Anna Cooper, C Parker Gibbs, Andre Spiguel
Allograft reconstruction of large segmental intercalary bone defects after tumor resection is a well-accepted surgical technique. Although results generally have been satisfactory, nonunion at the allograft-host bone junction site remains a notable concern. Various reports have described attempts to enhance junctional healing with a variety of complex osteotomies, often complicating an already complex procedure. The use of an innovative reverse reaming technique can decrease the level of intraoperative difficulty mating the allograft-host junction and theoretically may improve junctional healing by enhancing stability and increasing the contact surface area...
June 11, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29901424/phenotyping-the-microvasculature-in-critical-sized-calvarial-defects-via-multimodal-optical-imaging
#11
Adam Mendez, Alexandra N Rindone, Namrata Batra, Pegah Abassnia, Janaka Senarathna, Stacy Gil, Darian H Hadjiabadi, Warren L Grayson, Arvind P Pathak
Tissue engineered scaffolds are a powerful means of healing craniofacial bone defects arising from trauma or disease. Murine models of critical-sized bone defects are especially useful in understanding the role of microenvironmental factors such as vascularization on bone regeneration. Here we demonstrate the capability of a novel multimodality imaging platform capable of acquiring in vivo images of microvascular architecture, microvascular blood flow and tracer/cell tracking via intrinsic optical signaling (IOS), laser speckle contrast (LSC) and fluorescence imaging, respectively in a critical-sized calvarial defect model...
June 14, 2018: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29900480/bioactive-hybrid-zirconia-implant-surface-for-enhancing-osseointegration-an-in-vivo-study
#12
Dawlat Mostafa, Moustafa Aboushelib
BACKGROUND: Zirconia is characterized by a hard, dense, and chemically inert surface which requires additional surface treatments in order to enhance osseointegration. The proposed hypothesis of the study was that combination of a nano-porous surface infiltrated with a bioactive material may enhance osseointegration of zirconia implants. METHODS: Custom-made zirconia implants (3.7 mm × 8 mm) were designed, milled, and sintered according to manufacturer recommendations...
June 14, 2018: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/29900156/clinical-utility-of-biochemical-marker-of-bone-turnover-fracture-risk-prediction-and-bone-healing
#13
REVIEW
Byung-Ho Yoon, Woojin Yu
Bone turnover markers (BTMs) are released during bone remodeling and are thought to reflect the metabolic activity of bone at the cellular level. This review examines BTM as a biological response marker for monitoring future fracture prediction and fracture healing processes. Substantial evidence has been of high value to investigate the use of BTM in fracture risk prediction; nevertheless, the conclusions of some studies are inconsistent due to their large variability. BTM is promising for fracture risk prediction for adopting international reference standards or providing absolute risks, such as 10-year fracture probabilities...
May 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29898959/myeloid-cell-restricted-stat3-signaling-controls-a-cell-autonomous-antifibrotic-repair-program
#14
Nhu-Nguyen Do, Sebastian Willenborg, Beate Eckes, Christian Jüngst, Gerhard Sengle, Frank Zaucke, Sabine A Eming
Myeloid cells can be beneficial as well as harmful in tissue regenerative responses. The molecular mechanisms by which myeloid cells control this critical decision of the immune system are not well understood. Using two different models of physiological acute or pathological chronic skin damage, in this study we identified myeloid cell-restricted STAT3 signaling as important and an injury context-dependent regulator of skin fibrosis. Targeted disruption of STAT3 signaling in myeloid cells significantly accelerated development of pathological skin fibrosis in a model of chronic bleomycin-induced tissue injury, whereas the impact on wound closure dynamics and quality of healing after acute excision skin injury was minor...
June 13, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29898646/pure-bone-marrow-aspirate-injection-for-chronic-greater-trochanteric-pain-syndrome-a-case-report
#15
Rachel G Henderson, Ricardo E Colberg
There are limited treatment options for patients with a chronic refractory greater trochanteric pain syndrome. Orthobiologic interventions may stimulate tendon healing and improve pain and function in patients who fail the standard conservative treatment. Since the US FDA's new position statement regarding the centrifugation of bone marrow aspirate products as a potentially 'more than minimally manipulated' product, there is a growing concern about the most common bone marrow aspirate concentrate technique...
June 14, 2018: Pain Management
https://www.readbyqxmd.com/read/29898174/alveolar-bone-healing-in-rats-micro-ct-immunohistochemical-and-molecular-analysis
#16
Jaqueline Suemi Hassumi, Gabriel Mulinari-Santos, André Luis da Silva Fabris, Ricardo Garcia Mureb Jacob, Alaíde Gonçalves, Ana Cláudia Rossi, Alexandre Rodrigues Freire, Leonardo Pérez Faverani, Roberta Okamoto
INTRODUCTION: Alveolar bone healing after upper incisor extraction in rats is a classical model of preclinical studies. The underlying morphometric, cellular and molecular mechanism, however, remains imprecise in a unique study. OBJECTIVES: The aim of this study was therefore to characterize the alveolar bone healing after upper incisor extraction in rats by micro computed tomographic (Micro-CT), immunohistochemical and real-time polymerase chain reaction (RT-PCR) analysis...
June 11, 2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29898065/influence-of-genetic-polymorphisms-in-genes-of-bone-remodeling-and-angiogenesis-process-in-the-apical-periodontitis
#17
Jardel Francisco Mazzi-Chaves, Igor Bassi Ferreira Petean, Isadora Mello Vilarinho Soares, Alessandro Guimarães Salles, Lívia Azeredo Alves Antunes, Raquel Assed Bezerra Segato, Léa Assed Bezerra da Silva, Erika Calvano Küchler, Leonardo Santos Antunes, Manoel Damião Sousa-Neto
Persistent apical periodontitis (AP) is a situation involving an inflammatory and immune response caused mainly by anaerobic polymicrobial infection of the root canal system and the outcome and follow-up of the root canal treatment has been reported as intimately related to host response. The apical periodontitis repair might be associated with genetic polymorphisms. This study aimed to evaluate the association between HIF1A genetic polymorphisms (rs2301113 and rs2057482) with PAP in Brazilian patients. Subjects with at least 1 year of follow-up after root canal therapy (RCT) were recalled...
March 2018: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29897868/extended-trochanteric-osteotomy-comparison-of-3-modes-of-fixation-metallic-wires-cables-plate-about-a-series-of-157-cases
#18
Jean Louis Prudhon, Nicolas Tardy
INTRODUCTION: The trans femoral osteotomy was initially described by Wagner in 1987 and the extended trochanteric osteotomy (ETO) was described by Younger et al. in 1995 and is considered to be the gold standard technique for removal of well-fixed femoral stems in revision total hip arthroplasty (THA). The purpose of this report is: to compare the different types of fixation metallic wires, cables, metallic reinforcement plate (MRP) we have used in revision THA where an ETO was performed; analyse the clinical and radiological outcomes of these devices at 1 year; analyse the complication...
2018: SICOT-J
https://www.readbyqxmd.com/read/29897355/histologic-evaluation-of-soft-and-hard-tissue-healing-following-alveolar-ridge-preservation-with-deproteinized-bovine-bone-mineral-covered-with-xenogenic-collagen-matrix
#19
Luca Ramaglia, Raffaele Saviano, Giovanni Matarese, Francesco Cassandro, Ray C Williams, Gaetano Isola
The purpose of this study was to histologically evaluate new bone formation and dimensional soft tissue changes of two different healing protocols (16 weeks and 32 weeks) using deproteinized bovine bone mineral (DBBM) covered with collagen matrix (CM) for alveolar ridge preservation in the anterior esthetic zone prior to dental implant placement. Compared to baseline, both treatments yielded statistically significant differences in several clinical parameters and in the microarchitecture of the native bone and in the newly formed bone in the augmented sites...
June 12, 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29897354/a-histologic-and-histomorphometric-retrospective-analysis-of-the-outcomes-of-ridge-preservation-using-anorganic-bovine-bone-minerals-and-a-nonresorbable-membrane
#20
Seiko Min, Marcelo Freire, Neema Bakshallian, Ivy Wu, Homayoun H Zadeh
The objective of this study was to examine wound healing in extraction sockets following ridge preservation and the outcome of implants placed in those sites. Extraction sockets (N = 31) were grafted with anorganic bovine bone mineral (ABBM) and covered with dense polytetrafluoroethylene membrane. Bone cores obtained during implant placement were examined histologically and histomorphometrically. Percentages of vital bone and residual graft were 37.5% ± 21.3% and 12.5% ± 8.9%, respectively. New vital bone showed a negative correlation with patient age...
June 12, 2018: International Journal of Periodontics & Restorative Dentistry
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