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https://www.readbyqxmd.com/read/29656599/novel-cost-effective-cu-doped-calcium-silicate-nanoparticles-for-bone-fracture-intervention-inherent-bioactivity-and-in-vivo-performance
#1
Mostafa Mabrouk, Shaimaa A ElShebiney, Sayed H Kenawy, Gehan T El-Bassyouni, Esmat Ma Hamzawy
Copper (Cu)-doped calcium silicate nanoparticles were synthesized by a wet precipitation method as economical bone fracture filler. The aim was to improve the overall physicochemical properties, bioactivity, and biological performance of the bone fracture filler prepared herein. The synthesized nanoparticles were evaluated using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM). The bioactivity of the prepared nanoparticles was investigated after immersion in simulated body fluid (SBF) by means of inductively coupled plasma (ICP), SEM coupled with energy dispersive X-rays (EDX), and FTIR...
April 15, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29655780/dietary-flavonoid-kaempferol-inhibits-glucocorticoid-induced-bone-loss-by-promoting-osteoblast-survival
#2
Sulekha Adhikary, Dharmendra Choudhary, Naseer Ahmad, Anirudha Karvande, Avinash Kumar, Venkatesh Teja Banala, Prabhat Ranjan Mishra, Ritu Trivedi
OBJECTIVE: Kaempferol, a dietary flavonoid found in fruits and vegetables, has been reported to reverse osteopenic condition in ovariectomized rats. Because kaempferol is endowed with osteogenic activity, the aim of this study was to determine whether it has a beneficial effect on glucocorticoid (GC)-induced bone loss. METHODS: Adult female rats were divided into four groups as control (vehicle; distilled water), methylprednisolone (MP; 5 mg•kg•d, subcutaneously), MP + kaempferol (5 mg•kg•d, oral), and MP + human parathyroid 1-34 (30 µg/kg, 5 times/wk, subcutaneously) and treated for 4 wk...
February 13, 2018: Nutrition
https://www.readbyqxmd.com/read/29655367/biologic-plating-of-unstable-distal-radial-fractures
#3
Jae-Man Kwak, Gu-Hee Jung
BACKGROUND: Volar locking plating through the flexor carpi radialis is a well-established technique for treating unstable distal radial fractures, with few reported complications. In certain circumstances, including metaphyseal comminuted fractures, bridge plating through a pronator quadratus (PQ)-sparing approach may be required to preserve the soft tissue envelope. This study describes our prospective experience with bridge plating through indirect reduction. METHODS: Thirty-three wrists (four 23A2, six 23A3, 15 23C1, and eight 23C2) underwent bridge plating through a PQ-sparing approach with indirect reduction from June 2006 to December 2010...
April 14, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29653382/acute-exposure-of-white-tailed-deer-cortical-bone-to-staphylococcus-aureus-did-not-result-in-reduced-bone-stiffness
#4
Ariel Nicole Kunde, Victoria Jane Frost, Meir Max Barak
Staphylococcus aureus (S. aureus) is the main source of osteomyelitis in adults. The end-result of untreated osteomyelitis is bone necrosis and distraction of bone structure. While bone tissue can heal and remodel its structure to ameliorate its mechanical properties, so far no study has tested the mechanical properties of cortical bone tissue exposed to S. aureus. With the increase usage of bone banks as a source of bone graft supply, it is important to screen for any possible pathology that may affect the bone graft success to function normally in the receiving patient...
April 4, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29653317/increased-torsional-stability-by-a-novel-femoral-neck-locking-plate-the-role-of-plate-design-and-pin-configuration-in-a-synthetic-bone-block-model
#5
Jan Egil Brattgjerd, Martin Loferer, Sanyalak Niratisairak, Harald Steen, Knut Strømsøe
BACKGROUND: In undisplaced femoral neck fractures, internal fixation remains the main treatment, with mechanical failure as a frequent complication. As torsional stable fixation promotes femoral neck fracture healing, the Hansson Pinloc® System with a plate interlocking pins, was developed from the original hook pins. Since its effect on torsional stability is undocumented, the novel implant was compared with the original configurations. METHODS: Forty-two proximal femur models custom made of two blocks of polyurethane foam were tested...
March 27, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29653141/dual-mechanism-of-type-vii-collagen-transfer-by-bone-marrow-mesenchymal-stem-cell-extracellular-vesicles-to-recessive-dystrophic-epidermolysis-bullosa-fibroblasts
#6
Jeffrey McBride, Luis Rodriguez-Menocal, Ambar Candanedo, Wellington Guzman, Marta Garcia-Contreras, Evangelos Badiavas
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe blistering disease resulting from a lack of type VII collagen production. Recent clinical trials have shown efficacy of bone marrow-derived mesenchymal stem cells (BM-MSCs) in the treatment of epidermolysis bullosa, including improved basement membrane restructuring and cutaneous wound healing. The mechanism as to how type VII collagen is transferred from donor stem cell to recipient RDEB cells has not been defined. Here, we submit the model that BM-MSC-derived extracellular vesicles serve at least two roles: 1) to help transport type VII collagen within the extracellular space; and 2) to feed RDEB fibroblasts with messenger RNA that codes for type VII collagen, resulting in COL7A1 translation and synthesis of type VII collagen alpha chain proteins by RDEB fibroblasts...
April 10, 2018: Biochimie
https://www.readbyqxmd.com/read/29652605/improvement-of-bone-healing-by-neutralization-of-microrna-335-in-bmc-transplanted-in-a-femur-defect
#7
Maren Janko, Konstantin Dietz, Julia Rachor, Julian Sahm, Katrin Schroeder, Alex Schaible, Christoph Nau, Caroline Seebach, Ingo Marzi, Dirk Henrich
Transplanted bone marrow mononuclear cells (BMC) support the healing of large bone defects. Neutralization of microRNA (MiR) that negatively affects key processes of the reparative response in BMC might help to further improve the beneficial effect of transplanted BMC in bone healing. Hence, the aim of the current study was to evaluate, if the neutralization of MiR-92A (vascularization) and MiR-335-5p (osteogenic differentiation) in BMC using specific antiMiRs leads to a further improvement of the BMC supported therapy of large bone defects...
March 13, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29652023/actinomycotic-osteomyelitis-of-palate-masquerading-periapical-pathology-a-rare-case-report
#8
Prachi Baldawa, Pallavi Shirol, Dinraj Kulkarni, Supriya Koshti, Nitu Mishra
Osteomyelitis is an infection that is challenging to manage due to the poor vascularization of bone that favors the proliferation of microorganisms. We report a case of osteomyelitis occurring in endodontically treated teeth in the maxillary palatal region. Clinically and radiographically, it was initially diagnosed as osteomyelitis and was treated accordingly with antibiotics for 1 year with no reported healing. Later, biopsy was done and the findings were consistent with that of chronic osteomyelitis in association with infection by Actinomyces organisms...
March 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29651856/postoperative-fixation-after-repositioning-of-premaxilla-in-a-patient-with-bilateral-cleft-lip-and-palate-case-report
#9
M Koťová, M Dušková, E Leamerová, W Urbanová, K Schwarzmannová, K Novotná, A Sukop
This article presents orthodontic-surgical treatment in an eight-year-old patient with bilateral cleft lip and palate where premaxilla was surgically repositioned in the mixed dentition stage. By cranial and dorsal insertion of the premaxilla were created satisfactory occlusal relationship for ongoing eruption of permanent teeth, together with functional lip closure, improved pronunciation and a positive change in appearance of the centrofacial area. Reposition of premaxilla was associated with bilateral alveolar bone grafting of the cleft defect with cancellous bone from the iliac crest...
2018: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/29651831/does-age-affect-outcome-in-children-with-clavicle-fracture-treated-conservatively-quickdash-and-mrc-evaluation-of-131-consecutive-cases
#10
Vito Pavone, Claudia DE Cristo, Gianluca Testa, Federico Canavese, Ludovico Lucenti, Giuseppe Sessa
BACKGROUND: Non-operative treatment with immobilization is the gold-standard for paediatric clavicular fractures. Purpose of this study is to evaluate functional outcomes and efficacy of non-operative treatment of clavicular fractures in a succession of 131 children. METHODS: Between 2006 and 2012, we treated non-surgically 131 children for a clavicular fracture. All fractures have been classified according to Robinson classification. Clavicle shortening, range of movements and muscular strength through the Medical Research Council (MRC) scale were evaluated...
April 12, 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29651386/tissue-engineering-in-maxillary-bone-defects
#11
Azizollah Khodakaram-Tafti, Davood Mehrabani, Hanieh Shaterzadeh-Yazdi, Barbad Zamiri, Mahsa Omidi
BACKGROUND: Restoration of craniofacial bone defects has been a concern for oral and maxillofacial surgeons. In this study, the healing effect of fibrin glue scaffold was compared with autologous bone graft in mandibular defects of rabbit. METHODS: Bilateral unicortical osteotomy was performed in the diastema region of 10 male Dutch rabbits. The subjects were randomly divided into 2 equal groups. The mandibular defect on the right side was treated with fibrin glue scaffold and the defect on the left side with autologous bone graft provided from iliac crest...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29649067/outpatient-negative-pressure-wound-therapy-following-surgical-debridement-results-and-complications
#12
Eran Tamir, Aharon S Finestone, Itay Wiser, Yoram Anekstein, Gabriel Agar
OBJECTIVE: To present results and complications in a case series of outpatients with diabetic and neuropathic foot ulcers with exposed bone following surgical debridement treated with negative-pressure wound therapy (NPWT). METHODS: Retrospective data were obtained from digital medical records from the Maccabi Health Services High Risk Foot Clinic in Tel Aviv, Israel, between 2009 and 2014. Medical records examined were those of clinic outpatients with exposed bone following partial foot amputation or selective bone debridement (University of Texas grade III-A) treated with NPWT...
April 11, 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29649020/autologous-bone-flap-resorption-years-after-subtemporal-craniotomy
#13
John Oladapo Obafunwa, Emily Hammerl, David Jaskierny, Livia Taylor, Lynette Russell, Karl Reinhard
In Spring of 2012, the partially undressed and skeletonized remains of a homeless adult Hispanic male was found in a fairly open wooded area in Nebraska. The remains showed evidence of extensive pathologies, which included healed traumas and surgeries. Examination of the decedent's medical records revealed that he had a history of kidney and liver problems, alcohol abuse, several traumas including a major head injury that necessitated a craniotomy, and radiological features of neurocysticercosis. The autologous bone flap, which was replaced after the craniotomy, had resorbed significantly away from the edges of the injury...
April 11, 2018: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29645343/activation-of-hedgehog-signaling-by-systemic-agonist-improves-fracture-healing-in-aged-mice
#14
Jennifer A McKenzie, Clayton Maschhoff, Xiaochen Liu, Nicole Migotsky, Matthew J Silva, Michael J Gardner
Fracture healing is a complex process of many coordinated biological pathways. This system can go awry resulting in nonunion, which leads to significant patient morbidity. The Hedgehog (Hh) signaling pathway is upregulated in fracture healing. We hypothesized that the Hh signaling pathway can be pharmacologically modulated to positively affect fracture healing. Diaphyseal femur fractures were created in elderly mice (18 months, C57BL/6 females), which have a blunted and delayed healing response compared to younger mice, and were stabilized with intramedullary pins...
April 12, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29644275/delayed-identification-of-an-isolated-paediatric-capitate-fracture
#15
A Khoriati, C Jones, A Abdulkareem, N Ellahee
Fractures of the capitate bone are the second most common injury to a child's wrist but are rarely encountered in isolation. This is reflected in the paucity of described cases in the literature. Their true incidence is unknown as they often do not appear on plain radiographs and may heal without immobilisation. The easiest way to detect these fractures is with an MRI scan. The authors present a rare case of isolated capitate fracture that was initially missed on plain films. This case is important as it highlights the need for a high index of suspicion in paediatric patients with unresolving wrist pain...
December 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29644087/clinical-observation-of-biomimetic-mineralized-collagen-artificial-bone-putty-for-bone-reconstruction-of-calcaneus-fracture
#16
Yong-Xiong Pan, Guang-Gang Yang, Zhong-Wan Li, Zhong-Min Shi, Zhan-Dong Sun
This study investigated clinical outcomes of biomimetic mineralized collagen artificial bone putty for bone reconstruction in the treatment of calcaneus fracture. Sixty cases of calcaneal fractures surgically treated with open reduction and internal fixation in our hospital from June 2014-2015 were chosen and randomly divided into two groups, including 30 cases treated with biomimetic mineralized collagen artificial bone putty as treatment group, and 30 cases treated with autogenous ilia as control group. The average follow-up time was 17...
March 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29643002/3d-printing-of-a-lithium-calcium-silicate-crystal-bioscaffold-with-dual-bioactivities-for-osteochondral-interface-reconstruction
#17
Lei Chen, Cuijun Deng, Jiayi Li, Qingqiang Yao, Jiang Chang, Liming Wang, Chengtie Wu
It is difficult to achieve self-healing outcoming for the osteochondral defects caused by degenerative diseases. The simultaneous regeneration of both cartilage and subchondral bone tissues is an effective therapeutic strategy for osteochondral defects. However, it is challenging to design a single type of bioscaffold with suitable ionic components and beneficial osteo/chondral-stimulation ability for regeneration of osteochondral defects. In this study, we successfully synthesized a pure-phase lithium calcium silicate (Li2 Ca4 Si4 O13 , L2 C4 S4 ) bioceramic by a sol-gel method, and further prepared L2 C4 S4 scaffolds by using a 3D-printing method...
April 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29642944/concomitant-visceral-and-localized-cutaneous-leishmaniasis-in-two-moroccan-infants
#18
Tarik Mouttaki, Hasnaa Maksouri, Jilali El Mabrouki, Gema Merino-Espinosa, Hassan Fellah, Mohamed Itri, Joaquina Martin-Sanchez, Maha Soussi-Abdallaoui, Soumiya Chiheb, Myriam Riyad
BACKGROUND: Leishmaniases are vector-borne diseases caused by the protozoa of the Leishmania genus. The clinical spectrum of these diseases extends from benign dermal lesions to visceral forms. In the Mediterranean region, zoonotic visceral leishmaniasis (ZVL) is caused by L. infantum. If untreated within two years, the disease usually leads to death. In Morocco, ZVL is endemic in the north, with a hundred cases notified each year, mostly in children aged below five years. Here, we report on two clinical observations in infants presenting unusual concomitant VL and cutaneous leishmaniasis (CL) in Morocco...
April 12, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29642582/synthesis-of-a-novel-electrospun-polycaprolactone-scaffold-functionalized-with-ibuprofen-for-periodontal-regeneration-an-in-vitro-andin-vivo-study
#19
Fareeha Batool, David-Nicolas Morand, Lionel Thomas, Isaac Maximiliano Bugueno, Javier Aragon, Silvia Irusta, Laetitia Keller, Nadia Benkirane-Jessel, Henri Tenenbaum, Olivier Huck
Ibuprofen (IBU) has been shown to improve periodontal treatment outcomes. The aim of this study was to develop a new anti-inflammatory scaffold by functionalizing an electrospun nanofibrous poly-ε-caprolactone membrane with IBU (IBU-PCL) and to evaluate its impact on periodontal inflammation, wound healing and regeneration in vitro and in vivo. IBU-PCL was synthesized through electrospinning. The effects of IBU-PCL on the proliferation and migration of epithelial cells (EC) and fibroblasts (FB) exposed to Porphyromonas gingivlais lipopolysaccharide (Pg -LPS) were evaluated through the AlamarBlue test and scratch assay, respectively...
April 10, 2018: Materials
https://www.readbyqxmd.com/read/29642550/healing-of-osteochondral-defects-implanted-with-biomimetic-scaffolds-of-poly-%C3%AE%C2%B5-caprolactone-hydroxyapatite-and-glycidyl-methacrylate-modified-hyaluronic-acid-in-a-minipig
#20
Yi-Ho Hsieh, Bo-Yuan Shen, Yao-Horng Wang, Bojain Lin, Hung-Maan Lee, Ming-Fa Hsieh
Articular cartilage is a structure lack of vascular distribution. Once the cartilage is injured or diseased, it is unable to regenerate by itself. Surgical treatments do not effectively heal defects in articular cartilage. Tissue engineering is the most potential solution to this problem. In this study, methoxy poly(ethylene glycol)-block-poly(ε-caprolactone) (mPEG-PCL) and hydroxyapatite at a weight ratio of 2:1 were mixed via fused deposition modeling (FDM) layer by layer to form a solid scaffold. The scaffolds were further infiltrated with glycidyl methacrylate hyaluronic acid loading with 10 ng/mL of Transforming Growth Factor-β1 and photo cross-linked on top of the scaffolds...
April 9, 2018: International Journal of Molecular Sciences
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