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https://www.readbyqxmd.com/read/29235158/single-staged-implant-placement-using-bone-ring-technique-with-and-without-membrane-placement-an-experimental-study-in-the-beagle-dog
#1
Maiko Haga-Tsujimura, Ken Nakahara, Eizaburo Kobayashi, Kensuke Igarashi, Benoit Schaller, Nikola Saulacic
AIM: To evaluate the impact of a collagen membrane on bone remodeling and osseointegration of implants placed simultaneously with a bone ring technique. MATERIAL AND METHODS: Standardized, vertical alveolar bone defects in the mandibles of six dogs were created. Tapered dental implants designed for two-stage subcrestal placement were inserted simultaneously with a bone ring technique. On one side of the mandible, the augmented sites were covered with a collagenous membrane...
December 12, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29234746/short-implants-as-an-alternative-to-crestal-sinus-lift-a-3-year-multicentre-randomised-controlled-trial
#2
Giorgio Gastaldi, Pietro Felice, Roberto Pistilli, Carlo Barausse, Anna Trullenque-Eriksson, Marco Esposito
PURPOSE: To evaluate the efficacy of short (5 or 6 mm long) dental implants vs 10 mm or longer implants placed in crestally lifted sinuses. MATERIALS AND METHODS: Twenty partially edentulous patients with 5 to 7 mm of residual crestal height and at least 7 mm thickness below the maxillary sinuses as measured on computed tomography scans were randomised according to a parallel group design to receive either one to two 5 or 6 mm long implants (10 patients) or 10 mm long implants (10 patients) after crestal sinus lifting and grafting with anorganic bovine bone...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/29234653/evaluation-of-the-effectiveness-of-platelet-rich-plasma-in-the-bone-consolidation-of-patients-submitted-to-lumbar-arthrodesis
#3
Caroline Ferraz Rezende, Danielly de Paula Azevedo, Rafael Burgomeister Lourenço, José Fernando Duarte, Igor Machado Cardoso, Charbel Jacob Júnior
Objective: To determine whether the use of autograft associated with platelet-rich plasma (PRP) increases bone healing in patients undergoing lumbar fusion. Method: This was a prospective, descriptive, and comparative study, which included 40 patients undergoing lumbar fusion, who were divided into two groups: group I, autograft only, and group II, autograft associated with PRP. After surgery, patients were followed-up on the first, third, and sixth month. The Molinari radiographic classification and Glassman tomographic classification were used as criteria to analyze the bone consolidation...
November 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29234646/a-retrospective-analysis-of-surgically-treated-complex-proximal-femur-fractures-with-proximal-femoral-locking-compression-plate
#4
Syed Ibrahim, Jimmy Joseph Meleppuram
Objective: Analyze the outcomes of proximal femoral locking compression plate (PF-LCP) in these complex fractures. Methods: This study retrospectively analyzed 21 proximal femoral fractures treated with PF-LCP from June 2013 to February 2015. There were 15 females (71%) and six males (29%) with an average age of 61.4 years (range: 34-80 years). The peritrochanteric fractures constituted by intertrochanteric and subtrochanteric fractures were classified by the Boyd and Griffin classification and Seinshemier's classification, respectively...
November 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29232698/low-energy-extracorporeal-shockwave-therapy-eswt-improves-metaphyseal-fracture-healing-in-an-osteoporotic-rat-model
#5
Gina A Mackert, Matthias Schulte, Christoph Hirche, Dimitra Kotsougiani, Julian Vogelpohl, Bernd Hoener, Teresa Fiebig, Stefanie Kirschner, Marc A Brockmann, Marcus Lehnhardt, Ulrich Kneser, Leila Harhaus
PURPOSE: As result of the current demographic changes, osteoporosis and osteoporotic fractures are becoming an increasing social and economic burden. In this experimental study, extracorporeal shock wave therapy (ESWT), was evaluated as a treatment option for the improvement of osteoporotic fracture healing. METHODS: A well-established fracture model in the metaphyseal tibia in the osteoporotic rat was used. 132 animals were divided into 11 groups, with 12 animals each, consisting of one sham-operated group and 10 ovariectomized (osteoporotic) groups, of which 9 received ESWT treatment...
2017: PloS One
https://www.readbyqxmd.com/read/29232643/mechanical-corrosion-and-biocompatibility-behaviour-of-mg-3zn-ha-biodegradable-composites-for-orthopaedic-fixture-accessories
#6
Satish Jaiswal, R Manoj Kumar, Pallavi Gupta, Murali Kumaraswamy, Partha Roy, Debrupa Lahiri
Development of biodegradable implants has grown into one of the important areas in medical science. Degradability becomes more important for orthopaedic accessories used to support fractured and damaged bones, in order to avoid second surgery for their removal after healing. Clinically available biodegradable orthopaedic materials are mainly made of polymers or ceramics. These orthopaedic accessories have an unsatisfactory mechanical strength, when used in load-bearing parts. Magnesium and its alloys can be suitable candidate for this purpose, due to their outstanding strength to weight ratio, biodegradability, non-toxicity and mechanical properties, similar to natural bone...
November 21, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29230303/case-series-of-paragonimiasis-from-nepal
#7
Ranjit Sah, Shusila Khadka
Paragonimiasis is an important food-borne parasitic zoonosis caused by trematodes of genus Paragonimus. We report case series of paragonimiasis with common symptoms of cough with blood tinged sputum, shortness of breath, chest pain with occasional fever, eosinophilia and radiological findings mimicking pulmonary tuberculosis and had taken anti-tubercular drug despite all investigation negative for tuberculosis without improvement. They all had common history of consumption of raw/undercooked crab. There is a local belief in remote villages of Nepal that eating raw crab helps in healing bone fracture and cure jaundice...
November 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29230039/gli1-identifies-osteogenic-progenitors-for-bone-formation-and-fracture-repair
#8
Yu Shi, Guangxu He, Wen-Chih Lee, Jennifer A McKenzie, Matthew J Silva, Fanxin Long
Bone formation in mammals requires continuous production of osteoblasts throughout life. A common molecular marker for all osteogenic mesenchymal progenitors has not been identified. Here, by lineage-tracing experiments in fetal or postnatal mice, we discover that Gli1+ cells progressively produce osteoblasts in all skeletal sites. Most notably, in postnatal growing mice, the Gli1+ cells residing immediately beneath the growth plate, termed here "metaphyseal mesenchymal progenitors" (MMPs), are essential for cancellous bone formation...
December 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/29229668/multiple-myeloma-and-bone-the-fatal-interaction
#9
Silvia Marino, G David Roodman
Multiple myeloma (MM) is the second-most-common hematologic malignancy and the most frequent cancer to involve bone. MM bone disease (MMBD) has devastating consequences for patients, including dramatic bone loss, severe bone pain, and pathological fractures that markedly decrease the quality of life and impact survival of MM patients. MMBD results from excessive osteoclastic bone resorption and persistent suppressed osteoblastic bone formation, causing lytic lesions that do not heal, even when patients are in complete and prolonged remission...
December 11, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29228043/novel-systems-for-the-application-of-isolated-tensile-compressive-and-shearing-stimulation-of-distraction-callus-tissue
#10
Nicholaus Meyers, Julian Schülke, Anita Ignatius, Lutz Claes
BACKGROUND: Distraction osteogenesis is a procedure widely used for the correction of large bone defects. However, a high complication rate persists, likely due to insufficient stability during maturation. Numerical fracture healing models predict bone regeneration under different mechanical conditions allowing fixation stiffness optimization. However, most models apply a linear elastic material law inappropriate for the transient stresses/strains present during limb lengthening or segment transport...
2017: PloS One
https://www.readbyqxmd.com/read/29227827/determining-when-a-fracture-occurred-does-the-method-matter-analysis-of-the-similarity-of-three-different-methods-for-estimating-time-since-fracture-of-juvenile-long-bones
#11
Anne Drury, Craig Cunningham
Radiographic fracture date estimation is a critical component of skeletal trauma analysis in the living. Several timetables have been proposed for how the appearance of radiographic features can be interpreted to provide a likely time frame for fracture occurrence. This study compares three such timetables for pediatric fractures, by Islam et al. (2000), Malone et al. (2011), and Prosser et al. (2012), in order to determine whether the fracture date ranges produced by using these methods are in agreement with one another...
November 26, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29227581/aging-of-lymphoid-organs-can-photobiomodulation-reverse-age-associated-thymic-involution-via-stimulation-of-extrapineal-melatonin-synthesis-and-bone-marrow-stem-cells
#12
REVIEW
Denis Odinokov, Michael R Hamblin
Thymic atrophy and the subsequent reduction in T cell production are the most noticeable age-related changes affecting lymphoid organs in the immune system. In fact thymic involution has been described as "programmed aging". New therapeutic approaches such as photobiomodulation (PBM) may reduce or reverse these changes. PBM (also known as low-level laser therapy or LLLT) involves the delivery of non-thermal levels of red or near-infrared light that are absorbed by mitochondrial chromophores, in order to prevent tissue death and stimulate healing and regeneration...
December 11, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29226477/cell-therapy-for-critical-limb-ischemia-an-integrated-review-of-pre-clinical-and-clinical-studies
#13
REVIEW
Mohammad Qadura, Daniella C Terenzi, Subodh Verma, Mohammed Al-Omran, David A Hess
Critical limb ischemia (CLI), the most severe form of peripheral artery disease, is characterized by pain at rest and non-healing ulcers in the lower extremities. For patients with CLI, where the extent of atherosclerotic artery occlusion is too severe for surgical bypass or percutaneous interventions, limb amputation remains the only treatment option. Thus, cell-based therapy to restore perfusion and promote wound healing in patients with CLI is under intense investigation. Despite promising preclinical studies in animal models, transplantation of bone marrow (BM) derived cell populations in patients with CLI has shown limited benefit preventing limb amputation...
December 11, 2017: Stem Cells
https://www.readbyqxmd.com/read/29226199/effectiveness-of-minimally-invasive-plate-osteosynthesis-mipo-on-comminuted-tibial-or-femoral-fractures
#14
Ali Andalib, Erfan Sheikhbahaei, Zeynab Andalib, Mohammad A Tahririan
Background: Comminuted fractures happen frequently due to traumas. Fixation without opening the fracture site, known as minimally invasive plate osteosynthesis (MIPO), has recently become prevalent. This study has been designed to assess the outcomes of this treatment for tibial and femoral comminuted fractures. Methods: A total of 60 patients with comminuted femoral or tibial fractures were operated with MIPO method in this cross-sectional study at Alzahra university hospital in 2015...
September 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29225463/nano-copper-bearing-stainless-steel-promotes-fracture-healing-by-accelerating-the-callus-evolution-process
#15
Lei Wang, Guoyuan Li, Ling Ren, Xiangdong Kong, Yugang Wang, Xiuguo Han, Wenbo Jiang, Kerong Dai, Ke Yang, Yongqiang Hao
Treatment for fractures requires internal fixation devices, which are mainly produced from stainless steel or titanium alloy without biological functions. Therefore, we developed a novel nano-copper-bearing stainless steel with nano-sized copper-precipitation (317L-Cu SS). Based on previous studies, this work explores the effect of 317L-Cu SS on fracture healing; that is, proliferation, osteogenic differentiation, osteogenesis-related gene expression, and lysyl oxidase activity of human bone mesenchymal stem cells were detected in vitro...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29224947/functional-outcomes-of-compression-plating-and-bone-grafting-for-operative-treatment-of-nonunions-about-the-forearm
#16
Deirdre K Regan, Alexander M Crespo, Sanjit R Konda, Kenneth A Egol
PURPOSE: To describe one center's experience with nonunion of one or both bones of the forearm and report on the functional recovery of patients treated for a single- or 2-bone forearm nonunion. METHODS: We performed a retrospective analysis of 23 patients who presented to our institution over an 11-year period and underwent surgical repair of a forearm nonunion (radius, ulna, or both bones). The main outcome measurements included time to union, visual analog scale pain scores, range of motion, Short Musculoskeletal Function Assessment scores, and postoperative complications...
December 7, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29223735/targeting-secreted-cytokine-bmp9-gates-the-attenuation-of-hepatic-fibrosis
#17
Peng Li, Yongyun Li, Liqi Zhu, Zhi Yang, Jie He, Lihua Wang, Qingfeng Shang, Hui Pan, Huixue Wang, Xiong Ma, Bin Li, Xianqun Fan, Shengfang Ge, Renbing Jia, He Zhang
Liver fibrosis is overly exuberant wound healing that leads to portal hypertension or liver cirrhosis. Recent studies have demonstrated the functions of bone morphogenetic protein 9 (BMP9) in liver fibrosis, and thus, targeting liver-specific BMP9 abnormalities will become an attractive approach for developing therapeutics to treat liver fibrosis. Here, we reveal that BMP9 serves as a valuable serum diagnostic indicator and efficient therapeutic target to attenuate liver fibrogenesis. Our analysis of biopsies from liver fibrotic patients revealed that higher BMP9 levels accompanied advanced stages of liver fibrosis...
December 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29223594/femoral-neck-fractures-after-removal-of-hardware-in-healed-trochanteric-fractures
#18
REVIEW
Antonio Barquet, Peter V Giannoudis, Andrés Gelink
INTRODUCTION: Hardware removal in healed trochanteric fractures (TF) in the absence of infection or significant mechanical complications is rarely indicated. However, in patients with persistent pain, prominent material and discomfort in the activities of daily living, the implant is eventually removed. Publications of ipsilateral femoral neck fracture after removal of implants from healed trochanteric fractures (FNFARIHTF) just because of pain or discomfort are rare. The purpose of this systematic review of the literature is to report on the eventual risk factors, the mechanisms, the clinical presentation, and frequency, and to pay special emphasis in their prevention...
December 2017: Injury
https://www.readbyqxmd.com/read/29222809/effect-of-abutment-height-on-interproximal-implant-bone-level-in-the-early-healing-a-randomized-clinical-trial
#19
Juan Blanco, Alexandre Pico, Leticia Caneiro, Lourdes Nóvoa, Pilar Batalla, Pablo Martín-Lancharro
OBJECTIVE: The aim of this randomized clinical trial was to compare the effect on the interproximal implant bone loss (IBL) of two different heights (1 and 3 mm) of definitive abutments placed at bone level implants with a platform switched design. MATERIAL AND METHODS: Twenty-two patients received forty-four implants (6.5-10 mm length and 3.5-4 mm diameter) to replace at least two adjacent missing teeth, one bridge set to each patient-two implants per bridge...
December 8, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29222072/heparan-sulfate-potentiates-leukocyte-adhesion-on-cardiac-fibroblast-by-enhantcing-vcam-1-and-icam-1-expression
#20
Francisco Olivares-Silva, Rodolfo Landaeta, Pablo Aránguiz, Samir Bolivar, Claudio Humeres, Renatto Anfossi, Raúl Vivar, Pía Boza, Claudia Muñoz, Viviana Pardo-Jiménez, Concepción Peiró, Carlos F Sánchez-Ferrer, Guillermo Díaz-Araya
Cardiac fibroblasts (CF) act as sentinel cells responding to chemokines, cytokines and growth factors released in cardiac tissue in cardiac injury events, such as myocardial infarction (MI). Cardiac injury involves the release of various damage-associated molecular patterns (DAMPs) including heparan sulfate (HS), a constituent of the extracellular matrix (ECM), through the TLR4 receptor activation triggering a strong inflammatory response, inducing leukocytes recruitment. This latter cells are responsible of clearing cell debris and releasing cytokines that promote CF differentiation to myofibroblast (CMF), thus initiating scar formation...
December 5, 2017: Biochimica et Biophysica Acta
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