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https://www.readbyqxmd.com/read/29044037/-review-of-epidemiology-of-fractures-in-the-icelandic-heart-association-cohort
#1
Gunnar Sigurdsson, Kristin Siggeirsdottir, Brynjolfur Y Jonsson, Brynjolfur Morgensen, Elías F Gudmundsson, Thor Aspelund, Vilmundur Gudnason
IIn recent years, scientific papers have been published in Osteoporosis International on the epidemiology of fractures in Iceland based on the Icelandic Heart Association cohort. We report the main results with emphasis on the major osteoporotic fractures (MOF), distal forearm, upper arm, clinical vertebral and hip. Those four types of fractures have been reported to cause about 90% of the total burden of all osteoporotic fractures. The incidence of those four fractures in the Icelandic Heart Association cohort have been used as the basis for the international fracture risk calculator "FRAX "in Iceland...
October 2017: Læknablađiđ
https://www.readbyqxmd.com/read/29043392/complex-interventions-can-increase-osteoporosis-investigations-and-treatment-a-systematic-review-and-meta-analysis
#2
REVIEW
M Kastner, L Perrier, S E P Munce, C C Adhihetty, A Lau, J Hamid, V Treister, J Chan, Y Lai, S E Straus
Osteoporosis is affecting over 200 million people worldwide. Despite available guidelines, care for these patients remains sub-optimal. We developed an osteoporosis tool to address the multiple dimensions of chronic disease management. Findings from its evaluation showed a significant increase from baseline in osteoporosis investigations and treatment, so we are revising this tool to include multiple chronic conditions including an update of evidence about osteoporosis. Our objectives were to conduct a systematic review of osteoporosis interventions in adults at risk for osteoporosis...
October 18, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29038836/automated-dxa-based-finite-element-analysis-for-hip-fracture-risk-stratification-a-cross-sectional-study
#3
S Yang, W D Leslie, Y Luo, A L Goertzen, S Ahmed, L M Ward, I Delubac, L M Lix
Fracture risk indices (FRIs) generated from DXA-based finite element analysis were associated with hip fracture independent of FRAX score computed with femoral neck bone mineral density (BMD). Prospective studies are warranted to determine whether FRIs represent an improvement over BMD for predicting incident hip fractures. INTRODUCTION: The study aims to examine the association between prior hip fracture and FRIs derived from automated finite element analysis (FEA) of DXA hip scans. Femoral neck, intertrochanteric, and subtrochanteric FRIs were calculated as the von Mises stress induced by a sideways fall divided by the bone yield stress over the specified region of interest (ROI)...
October 6, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29038673/thiazides-and-osteoporotic-spinal-fractures-a-suspected-linkage-investigated-by-means-of-a-two-center-case-control-study
#4
Renato De Vecchis, Carmelina Ariano, Giuseppina Di Biase, Michel Noutsias
BACKGROUND: An alleged association of chronic use of thiazide diuretics with an increased risk of bone fragility fractures has been highlighted by a relatively recent prospective cohort study. However, the concept that thiazides exert a beneficial effect on osteoporosis is still a predominant view. This effect would be mediated by the decrease in renal clearance of calcium ions, a pharmacological feature recognized for a long time now to this class of drugs, as opposed to the increase in calcium urinary excretion attributed instead to loop diuretics, i...
November 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29038066/in-vitro-and-preclinical-assessment-of-an-intranasal-spray-formulation-of-parathyroid-hormone-pth-1-34-for-the-treatment-of-osteoporosis
#5
Allan J Williams, Faron Jordan, Gareth King, Andrew L Lewis, Lisbeth Illum, Tahir Masud, Alan C Perkins, Richard G Pearson
Osteoporosis treatment with PTH 1-34 injections significantly reduces the incidence of bone fracture. Potential further reductions in fracture rate should be observed through nasal spray delivery to address the poor compliance associated with patient dislike of repeated PTH 1-34 subcutaneous injections. In vitro human osteoblast-like Saos-2 cell intracellular cAMP levels were used to define PTH 1-34 nasal spray formulation bioactivity. The chemically synthesised PTH 1-34 had an EC50 of 0.76nM. Absorption enhancers polyethylene glycol (15)-hydroxystearate (Solutol(®) HS15), poloxamer 407, chitosan or sodium hyaluronate did not diminish the bioactivity of PTH 1-34 within an in vitro cell culture model (p >0...
October 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29033381/the-effect-of-once-yearly-zoledronic-acid-on-hip-structural-and-biomechanical-properties-derived-using-computed-tomography-ct-in-japanese-women-with-osteoporosis
#6
Masako Ito, Teruki Sone, Masataka Shiraki, Satoshi Tanaka, Chika Irie, Yuri Ota, Toshitaka Nakamura
The effects of zoledronic acid on hip structural and biomechanical properties were evaluated in Japanese patients with osteoporosis by computed tomography (CT). The subjects included in this study were a subset of female subjects (zoledronic acid group, 49 subjects; placebo group, 53 subjects) in the phase 3 trial (ZONE study) who were available for multi-detector row CT (MDCT) scanning. Eligible subjects were those diagnosed with primary osteoporosis based on the Diagnostic Criteria for Primary Osteoporosis (2000) by the Japanese Society for Bone and Mineral Research and who had between one and four fractured vertebrae located between the fourth thoracic vertebra and the fourth lumbar vertebra...
October 12, 2017: Bone
https://www.readbyqxmd.com/read/29032463/kit-w-sh-mutation-prevents-cancellous-bone-loss-during-calcium-deprivation
#7
Sutada Lotinun, Jaijam Suwanwela, Suchit Poolthong, Roland Baron
Calcium is essential for normal bone growth and development. Inadequate calcium intake increases the risk of osteoporosis and fractures. Kit ligand/c-Kit signaling plays an important role in regulating bone homeostasis. Mice with c-Kit mutations are osteopenic. The present study aimed to investigate whether impairment of or reduction in c-Kit signaling affects bone turnover during calcium deprivation. Three-week-old male WBB6F1/J-Kit (W) /Kit (W-v) /J (W/W (v) ) mice with c-Kit point mutation, Kit (W-sh) /HNihrJaeBsmJ (W (sh) /W (sh) ) mice with an inversion mutation in the regulatory elements upstream of the c-Kit promoter region, and their wild-type controls (WT) were fed either a normal (0...
October 14, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29032384/proton-pump-inhibitor-use-and-the-risk-of-osteoporosis-and-fracture-in-stroke-patients-a-population-based-cohort-study
#8
S-M Lin, S-H Yang, C-C Liang, H-K Huang
A considerable proportion of stroke survivors are prescribed with proton pump inhibitors (PPIs). Our study indicated that PPI use is associated with an increased risk of osteoporosis, hip fracture, and vertebral fracture in stroke patients. The risk tends to increase as the cumulative doses of PPIs increase. INTRODUCTION: A considerable proportion of stroke survivors are prescribed with proton pump inhibitors (PPIs). Our study investigated the association between PPI use and the risk of osteoporosis and fracture among stroke survivors...
October 14, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29032291/impact-of-an-osteoporosis-specialized-unit-on-bone-health-in-breast-cancer-survivals-treated-with-aromatase-inhibitors
#9
Purificación Martínez, Elena Galve, Virginia Arrazubi, M Ángeles Sala, Seila Fernández, Clara E Pérez, Juan F Arango, Iñaki Torre
OBJECTIVE: Considering the increased fracture risk in early breast cancer patients treated with aromatase inhibitors (AI), we assessed the impact of a preventive intervention conducted by a specialized osteoporosis unit on bone health at AI treatment start. MATERIAL AND METHODS: Retrospective cohort of postmenopausal women who started treatment with AI after breast cancer surgical/chemotherapy treatment and were referred to the osteoporosis unit for a comprehensive assessment of bone health...
October 11, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29032175/the-effect-of-raloxifene-on-bone-marrow-adipose-tissue-and-bone-turnover-in-postmenopausal-women-with-osteoporosis
#10
Kerensa Beekman, Annegreet G Veldhuis-Vlug, Martin den Heijer, Mario Maas, Ania M Oleksik, Michael W Tanck, Susan M Ott, Rob J Van't Hof, Paul Lips, Peter H Bisschop, Nathalie Bravenboer
In patients with postmenopausal osteoporosis low bone volume is associated with high bone marrow adipose tissue (MAT). Moreover, high MAT is associated with increased fracture risk. This suggests an interaction between MAT and bone turnover, however literature remains equivocal. Estrogen treatment decreases MAT, but the effect of raloxifene, a selective estrogen receptor modulator (SERM) registered for treatment of postmenopausal osteoporosis, on MAT is not known. The aim of this study is 1] to determine the effect of raloxifene on MAT and 2] to determine the relationship between MAT and bone turnover in patients with osteoporosis...
October 11, 2017: Bone
https://www.readbyqxmd.com/read/29031689/oral-administration-of-kaempferol-inhibits-bone-loss-in-rat-model-of-ovariectomy-induced-osteopenia
#11
Beata Nowak, Agnieszka Matuszewska, Anna Nikodem, Jarosław Filipiak, Marcin Landwójtowicz, Ewa Sadanowicz, Diana Jędrzejuk, Marta Rzeszutko, Krzysztof Zduniak, Tomasz Piasecki, Przemysław Kowalski, Wojciech Dziewiszek, Anna Merwid-Ląd, Małgorzata Trocha, Tomasz Sozański, Joanna Kwiatkowska, Marek Bolanowski, Adam Szeląg
BACKGROUND: Postmenopausal osteoporosis and osteoporotic fractures constitute an increasing problem in developing countries. Kaempferol, isolated from seeds of Cuscuta chinensis, is an active flavonoid inhibiting in vitro osteoclast activity. The aim of the presented research was an assessment of kaempferol effect on estrogen-deficiency-induced bone structure disturbances in rats. METHODS: The study was performed on 24 Wistar female rats divided into 3 groups: SHAM - rats undergoing a "sham" surgery, OVX-C - control group of animals that underwent ovariectomy, OVX-K - rats undergoing ovariectomy and receiving kaempferol for 8 weeks (from day 56 to day 112)...
May 13, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29030888/the-emperor-redressed-treating-osteoporosis-to-prevent-hip-fractures-in-the-oldest-old
#12
Bo Abrahamsen
Managing osteoporosis and preventing hip fractures in the oldest old remains a challenge surrounded by controversy and strong opinions. This is understandable given the paucity of randomized controlled trial (RCT) data in patients aged 80 years and above [1], the legitimate concerns that efficacy would disappoint given the multiple comedications and comorbid conditions that are prevalent in many of the oldest osteoporosis patients, and the probability that adverse effects would be more common and more severe in this age group...
October 14, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29030774/effects-of-growth-hormone-therapy-on-bone-density-and-fracture-risk-in-age-related-osteoporosis-in-the-absence-of-growth-hormone-deficiency-a-systematic-review-and-meta-analysis
#13
Maya Barake, Asma Arabi, Nancy Nakhoul, Ghada El-Hajj Fuleihan, Sarah El Ghandour, Anne Klibanski, Nicholas A Tritos
PURPOSE: In adults, growth hormone deficiency (GHD) has been associated with low bone mineral density (BMD), an effect counteracted by growth hormone (GH) replacement. Whether GH is beneficial in adults with age-related bone loss and without hypopituitarism is unclear. METHODS: We conducted a systematic literature search using Medline, Embase and the Cochrane Register of Controlled Trials. We extracted and analyzed data according to the bone outcome included [bone mineral content (BMC), BMD, and bone biomarker, fracture risk]...
October 13, 2017: Endocrine
https://www.readbyqxmd.com/read/29028268/relationship-between-the-mediterranean-dietary-pattern-and-musculoskeletal-health-in-children-adolescents-and-adults-systematic-review-and-evidence-map
#14
Jean V Craig, Diane K Bunn, Richard P Hayhoe, Will O Appleyard, Elizabeth A Lenaghan, Ailsa A Welch
An understanding of the modifiable effects of diet on bone and skeletal muscle mass and strength over the life course will help inform strategies to reduce age-related fracture risk. The Mediterranean diet is rich in nutrients that may be important for optimal musculoskeletal health. The aim of this systematic review was to investigate the relationship between a Mediterranean diet and musculoskeletal outcomes (fracture, bone density, osteoporosis, sarcopenia) in any age group. Ten electronic databases were searched...
October 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/29027270/the-yerba-mate-intake-has-a-neutral-effect-on-bone-a-case-control-study-in-postmenopausal-women
#15
Denise T A da Veiga, Raísa Bringhenti, Aline A Bolignon, Etiane Tatsh, Rafael N Moresco, Fabio V Comim, Melissa O Premaor
Nutritional factors have been associated with osteoporosis and fractures. The intake of coffee may increase the risk of fracture whereas the intake of black and green tea is associated with its reduction. Recently, consumption of yerba mate was associated with increased bone mineral density in postmenopausal women. Nonetheless, its influence on fracture is not known. The aim of this study was to evaluate the effect of yerba mate tea intake on fractures, bone markers, calcium homeostasis, and oxidative stress in postmenopausal women...
October 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29027045/characteristics-of-patients-with-fragility-hip-fractures-in-the-northern-kyushu-district-in-japan-a-multicenter-prospective-registry-based-on-an-electronic-data-capture-system
#16
Akiko Oyamada, Yoshihiro Matsumoto, Yoshifumi Wakata, Atsushi Kimura, Ko Ikuta, Kuniyoshi Tsuchiya, Naohisa Tayama, Shinji Tomari, Hisaaki Miyahara, Takao Mae, Hirokazu Shiraishi, Taichi Saito, Takeshi Arizono, Kozo Kaji, Taro Mawatari, Masami Fujiwara, Riku Sakimura, Kunichika Shin, Kenichi Ninomiya, Kazutoshi Nakaie, Yasuaki Antoku, Shoji Tokunaga, Naoki Nakashima, Yukihide Iwamoto, Yasuharu Nakashima
Osteoporosis has become a worldwide public health problem, in part due to the fact that it increases the risk of fragility hip fractures (FHFs). The epidemiological assessment of FHFs is critical for their prevention; however, datasets for FHFs in Japan remain scarce. This was a multicenter, prospective, observational study in the northern district of Kyushu Island. Inclusion criteria were age > 60 years with a diagnosis of FHF and acquisition of clinical data by an electronic data capture system. Of 1294 registered patients, 1146 enrolled in the study...
October 12, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29023918/scrutinizing-the-genetic-underpinnings-of-bone-strength
#17
Fernando Rivadeneira, Andre G Uitterlinden
Every year osteoporosis causes millions of fractures worldwide, with the lifetime risk of suffering a wrist, hip or vertebral fracture estimated to be about 30% in developed countries [1]. Osteoporosis has been operationally defined for diagnostic and treatment purposes on the basis of the bone mineral density (BMD) assessment performed at the skeletal sites where fracture is most common. Nevertheless, BMD measurement alone is not optimal for the detection of individuals at high risk of fracture.
October 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29022168/vertebral-heights-and-ratios-are-not-only-race-specific-but-also-gender-and-region-specific-establishment-of-reference-values-for-mainland-chinese
#18
Lei Ning, Li-Jiang Song, Shun-Wu Fan, Xing Zhao, Yi-Lei Chen, Zhao-Zhi Li, Zi-Ang Hu
This study established gender-specific reference values in mainland Chinese (MC) and is important for quantitative morphometry for diagnosis and epidemiological study of osteoporotic vertebral compressive fracture. Comparisons of reference values among different racial populations are then performed to demonstrate the MC-specific characteristic. PURPOSE: Osteoporotic vertebral compressive fracture (OVCF) is a common complication of osteoporosis in the elder population. Clinical diagnosis and epidemiological study of OVCF often employ quantitative morphometry, which relies heavily on the comparison of patients' vertebral parameters to existing reference values derived from the normal population...
October 11, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29022057/multiple-cannulated-screws-vs-dynamic-hip-screws-for-femoral-neck-fractures-a%C3%A2-meta-analysis
#19
Lei Lei Zhang, Ying Zhang, Xianghao Ma, Youwen Liu
OBJECTIVE: Various fixation devices have been reported for stabilization of femoral neck fractures. Numerous studies on arthroplasty versus internal fixation devices in the treatment of femoral neck fractures have been performed, but the optimal approach for internal fixation has not been analyzed. METHODS: A meta-analysis and system evaluation were performed to compare clinical effects. We searched PubMed, Embase, Cochrane Library, and Web of Science(TM) for randomized, controlled trials (RCTs) comparing multiple cannulated screws (MCS) with dynamic hip screws (DHS) and analyzed the failure rate of operations, the reoperation rate, and postoperative complications...
October 11, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/29019717/adding-vfa-to-dxa-identifies-fracture-risk-in-a-way-not-duplicated-by-other-measures
#20
Jay P Ginther, Ann W Ginther, Lisa D Brodersen
OBJECTIVE: Published studies have demonstrated that adding Vertebral Fracture Assessment (VFA) to Dual-energy X-ray Absorptiometry (DXA) identifies more patients with increased fracture risk than DXA alone. But who needs VFA? This study attempts to determine if some test, other than VFA, could duplicate the additional information obtained by performing VFA on ALL first-time patients. This study looked at FRAX, Height Loss, Age, documented back pain, and Non-vertebral Fragility Fractures (FFs)...
October 11, 2017: Endocrine Practice
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