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osteoporosis fracture

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https://www.readbyqxmd.com/read/29453659/fracture-risk-in-women-with-type-ii-diabetes-results-from-a-historical-cohort-with-fracture-follow-up
#1
Jakob Præst Holm, Thomas Jensen, Lars Hyldstrup, Jens-Erik Beck Jensen
PURPOSE: To examine the independent association between type II diabetes and fracture risk in a population of predominantly postmenopausal women referred to a specialist clinic for osteoporosis evaluation. METHODS: Type II diabetes associated fracture risk were evaluated among to 229 patients with type II diabetes in a cohort of 6285 women followed on average (until major osteoporotic fracture (MOF), death or end of study) for 5.8 years. Information of fracture risk factors was obtained from a clinical database and from national registries...
February 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29447485/should-women-be-screened-for-osteoporosis-at-midlife
#2
T J de Villiers
Osteoporosis and associated fractures are common in women after midlife and will increase as the population ages. Osteoporosis-related fractures cause a significant increase in morbidity and mortality. Osteoporosis decreases the quality of life and productivity of many older women, with an increasing burden on health-care resources. Future risk of fracture can be managed by evidence-based interventions. It is thus appropriate to estimate the future risk of fracture in all women at the age of 50 years or at menopause, whichever occurs first...
February 15, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29447437/j-shaped-association-between-post-operative-levothyroxine-dosage-and-fracture-risk-in-thyroid-cancer-patients-a-retrospective-cohort-study
#3
Dong Wook Shin, Beomseok Suh, Hyunsun Lim, Jae Moon Yun, Sun Ok Song, Youngmin Park
Long-term administration of supraphysiologic dosages of levothyroxine can have detrimental effect on the bone. We aimed to investigate fracture incidence among post-thyroidectomy thyroid cancer patients compared with matched comparison group, and explore the association between levothyroxine dosage and fracture risk. From the Korean National Health Insurance database, virtually all thyroid cancer patients who received thyroidectomy in Korea from January 1, 2004 to December 31, 2012 were included. Matched subjects were selected by 1:1 propensity score matching...
February 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29445836/bone-loss-after-romosozumab-denosumab-effects-of-bisphosphonates
#4
Anne M Horne, Borislav Mihov, Ian R Reid
Romosozumab and denosumab are monoclonal antibodies for the treatment of osteoporosis. Both have a rapid offset of effect resulting in loss of bone density (BMD) gained on-treatment and, in some cases, multiple vertebral fractures following treatment cessation. We recently reported disappointing results from transitioning patients from denosumab to intravenous zoledronate at the time the next denosumab injection is due. The present report re-assesses the role of bisphosphonates following the use of denosumab...
February 14, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29445831/using-a-sequential-explanatory-mixed-method-to-evaluate-the-therapeutic-window-of-opportunity-for-initiating-osteoporosis-treatment-following-fragility-fractures
#5
S Roux, I Gaboury, N Gionet-Landry, M-P Garant, M-C Beaulieu, N Carrier, F Cabana, G Boire
Interventions targeting patients with recent fragility fracture and their physician were most successful at initiating osteoporosis treatment during the first 12 months. This window of opportunity had already closed after 1 year. The reasons for declining or accepting the intensive intervention were explored in patients still untreated at 12 months. INTRODUCTION: A fragility fracture (FF) event identifies patients most likely to benefit from osteoporosis treatment. Nonetheless, most FF patients go untreated...
February 14, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29445830/bone-health-assessment-in-older-people-with-or-without-muscle-health-impairment
#6
M Locquet, C Beaudart, O Bruyère, J A Kanis, L Delandsheere, J-Y Reginster
This study investigated the relationship between muscle and bone status in elderly individuals. Our results suggested links between sarcopenia and osteoporosis; impairment in muscle status (i.e., muscle mass, muscle strength, and physical performance) is associated with deterioration in bone mass and texture subsequently leading to an increased risk of fracture. INTRODUCTION: Accumulating evidence has shown associations between sarcopenia and osteoporosis, but existing studies face inconsistencies in the clinical definition of both conditions...
February 14, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29441402/-left-to-my-own-devices-i-don-t-know-using-theory-and-patient-reported-barriers-to-move-from-physical-activity-recommendations-to-practice
#7
C Ziebart, C McArthur, L Lee, A Papaioannou, J Laprade, A M Cheung, R Jain, L Giangregorio
Knowledge exchange with community-dwelling individuals across Ontario revealed barriers to implementation of physical activity recommendations that reflected capability, opportunity, and motivation; barriers unique to individuals with osteoporosis include fear of fracturing, trust in providers, and knowledge of exercise terminology. Using the Behaviour Change Wheel, we identified interventions (training, education, modeling) and policy categories (communication/marketing, guidelines, service provision). INTRODUCTION: Physical activity recommendations exist for individuals with osteoporosis; however, to change behavior, we must address barriers and facilitators to their implementation...
February 13, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29440880/comparison-of-three-tools-for-predicting-primary-osteoporosis-in-an-elderly-male-population-in-beijing-a-cross-sectional-study
#8
XiaoDong Zhang, JiSheng Lin, Yong Yang, Hao Wu, Yongjin Li, Xiuquan Yang, Qi Fei
Purpose: In this cross-sectional study, three clinical tools, the Osteoporosis Self-Assessment Tool for Asians (OSTA), Fracture Risk Assessment Tool (FRAX) without bone mineral density (BMD), and body mass index (BMI), for predicting primary osteoporosis (OP) were compared and ideal thresholds for omission of screening BMD were proposed in a community-dwelling elderly Han Beijing male population. Patients and methods: A total of 1,349 community-dwelling elderly Han Beijing males aged ≥50 years were enrolled in this study...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29440373/calcium-supplementation-in-osteoporosis-useful-or-harmful
#9
Iacopo Chiodini, Mark J Bolland
Osteoporosis and fragility fractures are important social and economic problems worldwide and are due to both the loss of bone mineral density and sarcopenia. Indeed, fragility fractures are associated with increased disability, morbidity and mortality. It is known that a normal calcium balance together with a normal vitamin D status is important for maintaining well-balanced bone metabolism and for many years calcium and vitamin D has been considered crucial in the prevention and treatment of osteoporosis...
February 12, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29439698/a-retrospective-analysis-of-bone-mineral-status-in-patients-requiring-spinal-surgery
#10
Tobias Schmidt, Katharina Ebert, Tim Rolvien, Nicola Oehler, Jens Lohmann, Luca Papavero, Ralph Kothe, Michael Amling, Florian Barvencik, Haider Mussawy
BACKGROUND: Impaired bone quality is associated with poor outcome of spinal surgery. The aim of the study was to assess the bone mineral status of patients scheduled to undergo spinal surgery and to report frequencies of bone mineral disorders. METHODS: We retrospectively analyzed the bone mineral status of 144 patients requiring spinal surgery including bone mineral density by dual-energy X-ray absorptiometry (DXA) as well as laboratory data with serum levels of 25-hydroxyvitamin D (25-OH-D), parathyroid hormone, calcium, bone specific alkaline phosphate, osteocalcin, and gastrin...
February 13, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29438343/development-of-an-mhealth-application-for-women-newly-diagnosed-with-osteoporosis-without-preceding-fractures-a-participatory-design-approach
#11
Pernille Ravn Jakobsen, Anne Pernille Hermann, Jens Søndergaard, Uffe Kock Wiil, Jane Clemensen
mHealth is a useful tool to improve health outcome within chronic disease management. However, mHealth is not implemented in the field of postmenopausal osteoporosis even though it is a major worldwide health challenge. Therefore, this study aims to design and develop an mHealth app to support women in self-management of osteoporosis when they are diagnosed without preceding fractures. Participatory design is conducted in three phases. Based on identified needs in the first phase, a prototype is designed and developed in an iterative process in the second phase before the mHealth app is tested in the third phase...
February 13, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29435849/denosumab-a-review-in-postmenopausal-osteoporosis
#12
Emma D Deeks
Denosumab (Prolia®; Pralia®) is a human monoclonal antibody targeting the key bone resorption mediator RANKL. The drug is administered via subcutaneous injection once every 6 months and is approved for various indications, including the treatment of postmenopausal (PM) women with osteoporosis at increased/high risk of fracture or failure/intolerance of other osteoporosis therapies (indications featured in this review). Denosumab showed benefit in several phase 3 or 4 studies in PM women with osteoporosis or low bone mineral density (BMD), including the pivotal 3-year double-blind FREEDOM trial and its 7-year open-label extension...
February 12, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29435407/bmp3-expression-by-osteoblast-lineage-cells-is-regulated-by-canonical-wnt-signaling
#13
Shoichiro Kokabu, Vicki Rosen
Bone morphogenetic protein (BMP) and canonical Wnt (cWnt) signaling factors are both known to regulate bone mass, fracture risk, fracture repair, and osteoblastogenesis. BMP3 is the most abundant BMP and negatively regulates osteoblastogenesis and bone mass. Thus, identifying the mechanism by which BMP3 acts to depress bone formation may allow for the development of new therapeutics useful in the treatment for osteopenia and osteoporosis. Here, we report that cWnt signaling stimulates BMP3 expression in osteoblast (OB) lineage cells...
February 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29431298/radiographic-measurements-following-surgery-for-distal-radius-fractures-in-an-israeli-population
#14
Alan Katz, Amanda Almakias, Ronit Wollstein
BACKGROUND: Fractures of the distal radius are the most common fractures in the upper extremity, and their incidence is increasing with the aging of the population. Despite anatomical reduction of the bones, many patients complain of residual pain. A reason for this may be ligament injury not addressed during surgery or conservative treatment. Radiographic measurements may allow assessment of ligament integrity but they may be population specific and differ among races. OBJECTIVES: To assess radiographic wrist measurements in an Israeli population and to compare them to existing values...
February 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29430846/low-grip-strength-is-a-strong-risk-factor-of-osteoporosis-in-postmenopausal-women
#15
Yi-Zhong Li, Hua-Feng Zhuang, Si-Qing Cai, Chang-Kun Lin, Pei-Wen Wang, Li-Sheng Yan, Jin-Kuang Lin, Hai-Ming Yu
OBJECTIVE: To investigate the effect of grip strength on bone mineral density (BMD) in postmenopausal women. Low BMD is related to risk of fracture and falling is the strongest factor for fragility fractures. Handgrip strength is a reliable indicator of muscle strength and muscle strength is associated with falling. METHODS: For the present study 120 women were divided into two groups: those ≤65 years and those >65 years. Serum 25 hydroxyvitamin D (25OHD), BMD, and handgrip strength were measured to observe the effect of age on 25OHD, grip strength, and BMD, as well as the effect of 25OHD on grip strength and BMD...
February 12, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29429033/implementing-a-fracture-liaison-service-open-model-of-care-utilizing-a-cloud-based-tool
#16
S L Greenspan, A Singer, K Vujevich, B Marchand, D A Thompson, Y-J Hsu, D Vaidya, L S Stern, D Zeldow, D B Lee, S Karp, R Recker
PURPOSE: Although half of women and one-quarter of men aged 50 and older will sustain an acute low-trauma fracture, less than a quarter receive appropriate secondary fracture prevention. The goal of this quality improvement demonstration project was to implement a Fracture Liaison Service (FLS) focused on secondary prevention of an osteoporotic fracture in three open health care systems aided by a cloud-based tool. METHODS: The pre-post study design examined the proportion of men and women over age 50 who received appropriate assessment (bone mineral density, vitamin D levels) and treatment (calcium/vitamin D, pharmacologic therapy) in the six months following a recently diagnosed fracture...
February 10, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29427789/bone-tissue-aging-affects-mineralization-of-cement-lines
#17
Petar Milovanovic, Annika Vom Scheidt, Kathrin Mletzko, George Sarau, Klaus Püschel, Marija Djuric, Michael Amling, Silke Christiansen, Björn Busse
Cement lines are known as thin peripheral boundaries of the osteons. With a thickness below 5 μm their composition of inorganic and organic compounds has been a matter of debate. Here, we hypothesized that cement lines become hypermineralized and their degree of mineralization is not constant but related to the tissue age of the osteon. Therefore, we analyzed the calcium content of osteons and their corresponding cement lines in a range of different tissue ages reflected by osteonal mineralization levels in cadaveric femoral cortical bone of both postmenopausal women with osteoporosis and bisphosphonate-treated cases...
February 7, 2018: Bone
https://www.readbyqxmd.com/read/29427505/does-the-association-of-comorbidity-with-1-year-mortality-after-hip-fracture-differ-according-to-gender-the-norwegian-epidemiologic-osteoporosis-studies-norepos
#18
Brit Solvor L Riska, Lisa Forsén, Tone K Omsland, Anne Johanne Søgaard, Haakon E Meyer, Kristin Holvik
BACKGROUND/OBJECTIVES: Excess mortality after hip fracture is higher in men than in women. The objective was to study whether comorbidity differs in men and women with hip fracture and to what degree differences in comorbidity according to gender may explain the higher excess mortality in men. DESIGN: Population-based matched cohort covering the population aged 50 and older in Norway. SETTING: Specialist healthcare (individuals with hip fracture) and general population (controls)...
February 10, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29425296/inhibiting-cellular-senescence-a-new-therapeutic-paradigm-for-age-related-osteoporosis
#19
Sundeep Khosla, Joshua N Farr, James L Kirkland
Context: With the aging of the population and projected increase in osteoporotic fractures, coupled with the declining use of osteoporosis medications, there is a compelling need for new approaches to treat osteoporosis. Given that age-related osteoporosis generally co-exists with multiple other co-morbidities (e.g., atherosclerosis, diabetes, frailty), all sharing aging itself as the leading risk factor, there is growing interest in the "Geroscience Hypothesis", which posits that manipulation of fundamental aging mechanisms will delay the appearance or severity of multiple chronic diseases because these diseases share the same underlying risk factor - age...
February 7, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29424771/t-cell-receptor-activator-of-nuclear-factor-%C3%AE%C2%BAb-ligand-osteoprotegerin-imbalance-is-associated-with-hiv-induced-bone-loss-in-patients-with-higher-cd4-t-cell-counts
#20
Kehmia Titanji, Aswani Vunnava, Antonina Foster, Anandi N Sheth, Jeffrey L Lennox, Andrea Knezevic, Neeta Shenvi, Kirk A Easley, Ighovwerha Ofotokun, M Neale Weitzmann
OBJECTIVE: Higher incidence of osteopenia and osteoporosis underlie increased rates of fragility fracture in HIV infection. B cells are a major source of osteoprotegerin (OPG), an inhibitor of the key osteoclastogenic cytokine receptor activator of nuclear factor-κB ligand (RANKL). We previously showed that higher B-cell RANKL/OPG ratio contributes to HIV-induced bone loss. T-cell OPG production in humans, however, remains undefined and the contribution of T-cell OPG and RANKL to HIV-induced bone loss has not been explored...
February 8, 2018: AIDS
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