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network meta-analysis

Gary Tse, Cynthia Chan, Mengqi Gong, Lei Meng, Jian Zhang, Xiao-Ling Su, Sadeq Ali-Hasan-Al-Saegh, Abhishek C Sawant, George Bazoukis, Yun-Long Xia, Ji-Chao Zhao, Alex Pui Wai Lee, Leonardo Roever, Martin Cs Wong, Adrian Baranchuk, Tong Liu
Background: Heart failure is a significant problem leading to repeated hospitalizations. Telemonitoring and hemodynamic monitoring have demonstrated success in reducing hospitalization rates, but not all studies reported significant effects. The aim of this systematic review and meta-analysis is to examine the effectiveness of telemonitoring and wireless hemodynamic monitoring devices in reducing hospitalizations in heart failure. Methods & Results: PubMed and Cochrane Library were searched up to 1st May 2017 for articles that investigated the effects of telemonitoring or hemodynamic monitoring on hospitalization rates in heart failure...
April 2018: Journal of Geriatric Cardiology: JGC
Areti Angeliki Veroniki, Jesmin Antony, Sharon E Straus, Huda M Ashoor, Yaron Finkelstein, Paul A Khan, Marco Ghassemi, Erik Blondal, John D Ivory, Brian Hutton, Kevin Gough, Brenda R Hemmelgarn, Erin Lillie, Afshin Vafaei, Andrea C Tricco
BACKGROUND: Nearly all newly infected children acquire Human Immunodeficiency virus (HIV) via mother-to-child transmission (MTCT) during pregnancy, labour or breastfeeding from untreated HIV-positive mothers. Antiretroviral therapy (ART) is the standard care for pregnant women with HIV. However, evidence of ART effectiveness and harms in infants and children of HIV-positive pregnant women exposed to ART has been largely inconclusive. The aim of our systematic review and network meta-analysis (NMA) was to evaluate the comparative safety and effectiveness of ART drugs in children exposed to maternal HIV and ART (or no ART/placebo) across different study designs...
2018: PloS One
Eva Mennigen, Robyn L Miller, Barnaly Rashid, Susanna L Fryer, Rachel L Loewy, Barbara K Stuart, Daniel H Mathalon, Vince D Calhoun
New techniques to investigate functional network connectivity in resting state functional magnetic resonance imaging data have recently emerged. One novel approach, called meta-state analysis, goes beyond the mere cross-correlation of time courses of distinct brain areas and explores temporal dynamism in more detail, allowing for connectivity states to overlap in time and capturing global dynamic behavior. Previous studies have shown that patients with chronic schizophrenia exhibit reduced neural dynamism compared to healthy controls, but it is not known whether these alterations extend to earlier phases of the illness...
June 12, 2018: Schizophrenia Research
Pan Song, Chuiguo Huang, Yan Wang
AIMS: The aim of this study was to compare the efficacy and safety of docetaxel, cabazitaxel, docetaxel + estramustine, mitoxantrone in the management of castration-resistant prostate cancer (CRPC). METHODS: Electronic databases including PubMed, Cochrance Library and Embase were searched for studies published from when the databases were established to January 1 s t, 2018. Randomized controlled trials (RCTs) that compared docetaxel + prednisone (DP), cabazitaxel + prednisone (CP), docetaxel + estramustine + prednisone (DEP), and mitoxantrone + cabazitaxel prednisone (MP) for CRPC treatment were identified...
June 12, 2018: International Journal of Surgery
Gill Norman, Maggie J Westby, Amber D Rithalia, Nikki Stubbs, Marta O Soares, Jo C Dumville
BACKGROUND: Venous leg ulcers are open skin wounds on the lower leg which can be slow to heal, and are both painful and costly. The point prevalence of open venous leg ulcers in the UK is about 3 cases per 10,000 people, and many people experience recurrent episodes of prolonged ulceration. First-line treatment for venous leg ulcers is compression therapy, but a wide range of dressings and topical treatments are also used. This diversity of treatments makes evidence-based decision-making challenging, and a clear and current overview of all the evidence is required...
June 15, 2018: Cochrane Database of Systematic Reviews
Hongliang Wang, Hongshuang Tong, Haitao Liu, Yao Wang, Ruitao Wang, Hong Gao, Pulin Yu, Yanji Lv, Shuangshuang Chen, Guiyue Wang, Miao Liu, Yuhang Li, Kaijiang Yu, Changsong Wang
BACKGROUND: Catheter-related blood-stream infections (CRBSIs) are the most common complication when using central venous catheters (CVCs). Whether coating CVCs under bundles could further reduce the incidence of CRBSIs is unclear. We aimed to assess the effectiveness of implementing the use of bundles with antimicrobial-coated CVCs for preventing catheter-related blood-stream infections. METHODS: In this systematic review and network meta-analyses, we searched the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library in addition to the EMBASE, MEDLINE, CINAHL, and Web of Science databases for studies published before July 2017...
June 15, 2018: Annals of Intensive Care
Feng-Bin Lu, En-De Hu, Lan-Man Xu, Yi-Bing Hu, Lu Chen, Jin-Lu Wu, Hui Li, Da-Zhi Chen, Yong-Ping Chen
The most suitable treatment regimen for autoimmune hepatitis (AIH) in adults remains unknown and requires further investigation. The current study therefore aimed to integrate evidence to provide hierarchies of the comparative efficacies of treatments measured by clinical and biochemical remission. A Bayesian-framework network meta-analysis of randomized controlled trials (RCTs) was preformed to compare eight treatments for AIH. Eligible RCTs were identified by searching Embase, Pubmed and the Cochrane Library for publications between 1966 and April 2017...
June 2018: Experimental and Therapeutic Medicine
Leonardo Roever, Elmiro Santos Resende, Angélica Lemos Debs Diniz, Nilson Penha-Silva, João Lucas O'Connell, Paulo Fernando Silva Gomes, Hugo Ribeiro Zanetti, Anaisa Silva Roerver-Borges, Fernando César Veloso, Fernanda Rodrigues de Souza, Poliana Rodrigues Alves Duarte, Thiago Montes Fidale, Antonio Casella-Filho, Paulo Magno Martins Dourado, Antonio Carlos Palandri Chagas, Sadeq Ali-Hasan-Al-Saegh, Paulo Eduardo Ocke Reis, Rogério de Melo Costa Pinto, Gustavo B F Oliveira, Álvaro Avezum, Mansueto Neto, André Rodrigues Durães, Rose Mary Ferreira Lisboa da Silva, Antonio José Grande, Celise Denardi, Renato Delascio Lopes, Nitesh Nerlekar, Shahab Alizadeh, Adrian V Hernandez, Maria Inês da Rosa, Giuseppe Biondi-Zoccai
INTRODUCTION: The prevalence of metabolic syndrome (MetS) and MetS-related stroke is set to increase dramatically in coming decades. MetS is a complex disease that includes endothelial dysfunction, insulin resistance, diabetes, hypertension, ectopic obesity, and dyslipidaemia and an increased risk of cardiovascular events. One function of high-density lipoprotein (HDL) cholesterol (HDL-C) is the cholesterol-efflux pathway, which is the pathway where cholesterol is removed from macrophages within the arterial walls back into the bloodstream and out to the liver...
June 2018: Medicine (Baltimore)
Zehao Zhu, Yuanping Wang, Weilin Liao, Huimin Li, Dawei Wang
BACKGROUND: Patients with coronary heart disease (CHD) who undergo percutaneous coronary intervention (PCI) have a certain risk of vascular complications, including coronary restenosis and thrombosis. Many recent randomized controlled trials have reported that Danshen injection (DSI) combined with conventional Western medicine can significantly reduce the occurrence of major cardiovascular adverse events in patients with CHD after PCI. However, there are many types of DSIs, and no study has yet compared each type...
June 2018: Medicine (Baltimore)
Reza Dehnavieh, AliAkbar Haghdoost, Ardeshir Khosravi, Fahime Hoseinabadi, Hamed Rahimi, Atousa Poursheikhali, Nahid Khajehpour, Zahra Khajeh, Nadia Mirshekari, Marziyeh Hasani, Samera Radmerikhi, Hajar Haghighi, Mohammad Hossain Mehrolhassani, Elaheh Kazemi, Saeide Aghamohamadi
BACKGROUND: Health information systems offer many potential benefits for healthcare, including financial benefits and for improving the quality of patient care. The purpose of District Health Information Systems (DHIS) is to document data that are routinely collected in all public health facilities in a country using the system. OBJECTIVE: The aim of this study was to examine the strengths and operational challenges of DHIS2, with a goal to enable decision makers in different counties to more accurately evaluate the outcomes of introducing DHIS2 into their particular country...
January 1, 2018: Health Information Management: Journal of the Health Information Management Association of Australia
Alessia Celeghin, Arianna Bagnis, Matteo Diano, Andrés Méndez Guerrero, Tommaso Costa, Marco Tamietto
Blindsight, the residual abilities of patients with cortical blindness to respond proficiently to stimuli they do not consciously acknowledge, offers a unique opportunity to study the functional and anatomical mechanisms sustaining visual awareness. Over decades, the phenomenon has been documented in a wide number of different patients, across independent laboratories, and for a variety of tasks and stimulus properties. Nevertheless, the functional neuroanatomy of blindsight remains elusive and alternative proposals have been put forth...
June 9, 2018: Neuropsychologia
Frank Kloprogge, Lesley Workman, Steffen Borrmann, Mamadou Tékété, Gilbert Lefèvre, Kamal Hamed, Patrice Piola, Johan Ursing, Poul Erik Kofoed, Andreas Mårtensson, Billy Ngasala, Anders Björkman, Michael Ashton, Sofia Friberg Hietala, Francesca Aweeka, Sunil Parikh, Leah Mwai, Timothy M E Davis, Harin Karunajeewa, Sam Salman, Francesco Checchi, Carole Fogg, Paul N Newton, Mayfong Mayxay, Philippe Deloron, Jean François Faucher, François Nosten, Elizabeth A Ashley, Rose McGready, Michele van Vugt, Stephane Proux, Ric N Price, Juntra Karbwang, Farkad Ezzet, Rajesh Bakshi, Kasia Stepniewska, Nicholas J White, Philippe J Guerin, Karen I Barnes, Joel Tarning
BACKGROUND: The fixed dose combination of artemether-lumefantrine (AL) is the most widely used treatment for uncomplicated Plasmodium falciparum malaria. Relatively lower cure rates and lumefantrine levels have been reported in young children and in pregnant women during their second and third trimester. The aim of this study was to investigate the pharmacokinetic and pharmacodynamic properties of lumefantrine and the pharmacokinetic properties of its metabolite, desbutyl-lumefantrine, in order to inform optimal dosing regimens in all patient populations...
June 2018: PLoS Medicine
Ka H C Li, Mei Dong, Mengqi Gong, George Bazoukis, Ishan Lakhani, Yan Y Ting, Sunny H Wong, Guangping Li, William K K Wu, Vassilios S Vassiliou, Martin C S Wong, Konstantinos Letsas, Yimei Du, Victoria Laxton, Bryan P Yan, Yat S Chan, Yunlong Xia, Tong Liu, Gary Tse
Background and Objectives: Atrial fibrillation is a common abnormal cardiac rhythm caused by disorganized electrical impulses. AF which is refractory to antiarrhythmic management is often treated with catheter ablation. Recently a novel ablation system (nMARQ) was introduced for PV isolation. However, there has not been a systematic review of its efficacy or safety compared to traditional ablation techniques. Therefore, we conducted this meta-analysis on the nMARQ ablation system. Methods: PubMed and EMBASE were searched up until 1st of September 2017 for articles on nMARQ...
2018: Frontiers in Physiology
Amin Doosti-Irani, Kourosh Holakouie-Naieni, Abbas Rahimi-Foroushani, Mohammad Ali Mansournia, Peiman Haddad
We aimed to compare treatments for patients with esophageal squamous cell carcinoma (SCC) in terms of survival. Medline, Web of Science, Scopus, the Cochrane Library and Embase were searched. Randomized controlled trials (RCT) that had compared esophageal SCC treatments were included. The hazard ratio (HR) with 95% credible interval (CrI) was used to summarize the effect measures in the Bayesian network meta-analysis. Out of 23,256 references, 43 RCTs with 34 treatments were included. Carboplatin and paclitaxel plus radiotherapy plus surgery (carbo-pacli + RT + S) compared with surgery alone decreased risk of death (HR = 0...
July 2018: Critical Reviews in Oncology/hematology
Luis Miguel Rondón García, Jose Manuel Ramírez Navarrro
Background: This research analyzes the impact of quality of life as a metavariable that conditions the health and social welfare of the elderly. The sample of this study is composed of 500 people, randomly selected from the major day centers for the elderly in the province of Granada (Spain). Method: For the inferential analysis, we used the CUBRECAVI questionnaire, which is a multidimensional scale of health and quality of life, along with the Katz and García measure questionnaires, which are also applied to quality of life...
2018: Journal of Aging Research
Majed S Al Yami, Osamah M Alfayez, Razan Alsheikh
The aim of this mixed treatment comparison (MTC) meta-analysis was to determine glucagon like peptide-1 (GLP-1) receptor agonists' effects on cardiovascular (CV) outcomes in patients with type 2 diabetes (T2DM). METHODS: A comprehensive, systematic review was conducted using EMBASE and Medline databases. All included trials were large CV outcome trials of GLP-1 agonists versus placebo in T2DM. The primary outcomes of this MTC meta-analysis were death from CV causes, non-fatal MI, and non-fatal stroke...
March 29, 2018: Heart, Lung & Circulation
Elisa González-Domínguez, Giorgia Fedele, Tito Caffi, Laurent Delière, Pierre Sauris, David Gramaje, José Luis Ramos-Sáez de Ojer, Emilia Díaz-Losada, Ana M Díez-Navajas, Paul Bengoa, Vittorio Rossi
BACKGROUND: Control of Botrytis bunch rot (BBR) is currently based on the application of fungicides at four timings corresponding to specific growth stages of vines: end of flowering (A), pre-bunch closure (B), veraison (C) and before harvest (D). The current research provides a network meta-analysis of 116 studies conducted between 1963 and 2016 in nine countries, in which 14 strategies (based on combinations of 1, 2, 3, or 4 sprays applied in A, B, C, and/or D) were compared. RESULTS: When a 1-spray strategy was applied, BBR control was more effective with sprays applied in A, C, or D than B...
June 9, 2018: Pest Management Science
Tsegaselassie Workalemahu, Daniel A Enquobahrie, Bizu Gelaye, Sixto E Sanchez, Pedro J Garcia, Fasil Tekola-Ayele, Anjum Hajat, Timothy A Thornton, Cande V Ananth, Michelle A Williams
INTRODUCTION: Accumulating epidemiological evidence points to strong genetic susceptibility to placental abruption (PA). However, characterization of genes associated with PA remains incomplete. We conducted a genome-wide association study (GWAS) of PA and a meta-analysis of GWAS. METHODS: Participants of the Placental Abruption Genetic Epidemiology (PAGE) study, a population based case-control study of PA conducted in Lima, Peru, were genotyped using the Illumina HumanCore-24 BeadChip platform...
June 2018: Placenta
Zening Fu, Yiheng Tu, Xin Di, Yuhui Du, Jing Sui, Bharat B Biswal, Zhiguo Zhang, N de Lacy, V D Calhoun
Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with social communication deficits and restricted/repetitive behaviors and is characterized by large-scale atypical subcortical-cortical connectivity, including impaired resting-state functional connectivity between thalamic and sensory regions. Previous studies have typically focused on the abnormal static connectivity in ASD and overlooked potential valuable dynamic patterns in brain connectivity. However, resting-state brain connectivity is indeed highly dynamic, and abnormalities in dynamic brain connectivity have been widely identified in psychiatric disorders...
June 5, 2018: NeuroImage
Hyunsoo Hwang, Stacia M DeSantis
Outcome reporting bias (ORB) is recognized as a threat to the validity of both pairwise and network meta-analysis (NMA). In recent years, multivariate meta-analytic methods have been proposed to reduce the impact of ORB in the pairwise setting. These methods have shown that multivariate meta-analysis can reduce bias and increase efficiency of pooled effect sizes. However, it is unknown whether multivariate NMA (MNMA) can similarly reduce the impact of ORB. Additionally, it is quite challenging to implement MNMA due to the fact that correlation between treatments and outcomes must be modeled; thus, the dimension of the covariance matrix and number of components to estimate grows quickly with the number of treatments and number of outcomes...
June 7, 2018: Statistics in Medicine
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