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https://www.readbyqxmd.com/read/28749627/acute-kidney-injury-in-pediatric-patients-diagnosis-and-management-in-the-emergency-department-digest
#1
Daniel Mohrer, Melissa Langhan, Pradip Chaudhari
Pediatric acute kidney injury is a condition that is underdiagnosed among children seen in the emergency department, and it has been associated with significant morbidity and mortality, including increased risk for chronic kidney disease. The most common etiologies in pediatric patients are now known to be due to hypovolemia, sepsis, shock, and cardiac dysfunction. This issue compares 3 classification systems for the diagnosis and staging of acute kidney injury and reviews the etiologies that lead to kidney injury in children...
May 22, 2017: Pediatric Emergency Medicine Practice
https://www.readbyqxmd.com/read/28749588/primary-cutaneous-cd4-positive-small-medium-sized-pleomorphic-t-cell-lymphoproliferative-disorder-report-of-a-case-and-review-of-the-literature
#2
Brett H Keeling, Alde Carlo P Gavino, Joan Admirand, Anthony C Soldano
Primary cutaneous small/medium-sized T-cell lymphoma (PCSM-TCL), which was included in the WHO-EORTC classification for cutaneous lymphomas as a provisional entity in 2008, has recently been reclassified as a lymphoproliferative disorder (PCSM-TCLPD) due to its indolent behavior and uncertain malignant potential. Treatment with local therapies is usually curative, though there have been reports of aggressive, systemic disease. This spectrum of disease behavior evokes the consideration that this entity may actually be multiple diseases with a shared clinicopathologic features rather than a singular disease process with a variety of behaviors...
July 27, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28749427/advanced-growth-factor-delivery-systems-in-wound-management-and-skin-regeneration
#3
REVIEW
Jin Woo Park, Seung Rim Hwang, In-Soo Yoon
Growth factors are endogenous signaling molecules that regulate cellular responses required for wound healing processes such as migration, proliferation, and differentiation. However, exogenous application of growth factors has limited effectiveness in clinical settings due to their low in vivo stability, restricted absorption through skin around wound lesions, elimination by exudation prior to reaching the wound area, and other unwanted side effects. Sophisticated systems to control the spatio-temporal delivery of growth factors are required for the effective and safe use of growth factors as regenerative treatments in clinical practice, such as biomaterial-based drug delivery systems (DDSs)...
July 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28749317/understanding-the-use-of-geographical-information-systems-gis-in-health-informatics-research-a-review
#4
Nicola Shaw, Suzanne McGuire
BACKGROUND: The purpose of this literature review is to understand geographical information systems (GIS) and how they can be applied to public health informatics, medical informatics, and epidemiology. METHOD: Relevant papers that reflected the use of geographical information systems (GIS) in health research were identified from four academic databases: Academic Search Complete, BioMed Central, PubMed Central, and Scholars Portal, as well as Google Scholar. The search strategy used was to identify articles with "geographic information systems", "GIS", "public health", "medical informatics", "epidemiology", and "health geography" as main subject headings or text words in titles and abstracts...
June 23, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28749273/a-retrospective-review-of-western-lowland-gorilla-gorilla-gorilla-gorilla-mortality-in-european-zoologic-collections-between-2004-and-2014
#5
Victoria Strong, Kerstin Baiker, Marnie L Brennan, Sharon Redrobe, Frank Rietkerk, Malcolm Cobb, Kate White
An understanding of the main causes of mortality among captive gorillas is imperative to promoting their optimal care, health, and welfare. A retrospective observational review of mortality among the European zoo-housed western lowland gorilla ( Gorilla gorilla gorilla) population from 2004 to 2014 was carried out. This is the first published study of mortality in this population. Relevant postmortem data were requested from each collection reporting a death during the study period. Age at death enabled grouping into discrete age categories...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749245/advances-in-our-understanding-of-immunization-and-vaccines-for-patients-with-systemic-lupus-erythematosus
#6
Nicola Luigi Bragazzi, Abdulla Watad, Kassem Sharif, Mohammad Adawi, Gali Aljadeff, Howard Amital, Yehuda Shoenfeld
INTRODUCTION: Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease. In SLE, immune system dysfunction is postulated to result by virtue of the disease itself as well as by the impact of treatment modalities employed. A myriad of immune dysregulations occur including complement system dysfunction among others. Infectious agents are known to complicate the disease course in close to 25-45 % of SLE patients. METHODS: In this review a discussion of the immunogenicity and safety of viral and bacterial vaccinations in SLE was performed...
July 27, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28749123/-infectious-complications-related-to-external-ventricular-shunt-incidence-and-risk-factors
#7
L López-Amor, L Viña, L Martín, C Calleja, R Rodríguez-García, I Astola, L Forcelledo, L Álvarez-García, C Díaz-Gómez, J Fernández-Domínguez, F Vázquez, D Escudero
OBJECTIVE: Infectious complications related to external ventricular shunt (ICREVS) are a main problem in neurocritical intensive care units (ICU). The aim of the review is to assess the incidence of ICREVS and to analyse factors involved. METHODS: Retrospective analysis, adult polyvalent ICU in a third level reference hospital. Patients carrying external ventricular shunt (DVE) were included. Those patients with central nervous system infection diagnosed prior DVE placement were excluded...
July 25, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28749114/characteristics-and-outcomes-of-patients-with-hematological-malignancies-admitted-for-intensive-care-a-single-centre-experience
#8
Shafaq Maqsood, Farhana Badar, Abdul Hameed
Background and Purpose: Patients with hematological malignancies admitted to an intensive care unit (ICU) generally have a high mortality rate. The aim of our study was to assess the characteristics and outcomes of such patients and to identify factors predicting ICU mortality. Material and Methods: This retrospective chart review was conducted in the intensive care unit (ICU) of Shaukat Khanum Memorial Cancer Hospital and Research Centre over a period of 5 years, from January 2010 to January 2015. Results: Characteristics :A total of 213 patients were included in this study...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749102/an-exploration-of-phytochemicals-from-simaroubaceae
#9
Biba Vikas, B S Akhil, P S R Suja, K Sujathan
Natural products such as plants, animals and minerals have been the basis of treatment of human diseases. Herbal remedies have been used for the treatment of many ailments. Many compounds have been derived from the plant species mentioned in the ancient texts of Indian system of medicine for the treatment of a number of ailments. The R and D thrust in the pharmaceutical sector is focused on development of new drugs, innovative/indigenous processes for known drugs and development of plant based drugs through investigation of leads from the traditional systems of medicine...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749070/diagnostic-accuracy-of-magnetic-resonance-imaging-mri-5-point-likert-scoring-system-evaluated-by-the-result-of-mri-ultrasonography-image-fusion-targeted-biopsy-of-the-prostate
#10
Toshitaka Shin, Thomas B Smyth, Osamu Ukimura, Nariman Ahmadi, Andre Luis de Castro Abreu, Chisato Ohe, Masakatsu Oishi, Hiromitsu Mimata, Inderbir S Gill
OBJECTIVE: To evaluate the accuracy of MRI based Likert scoring system in detection of clinically significant prostate cancer (CSPC) using MRI/Ultrasonography (US) image-fusion targeted biopsy (FTB) as a reference standard. PATIENTS AND METHODS: We retrospectively reviewed 1218 MRI-lesions in 629 patients who underwent subsequent MRI/US FTB between 10/2012 and 8/2015. 3-Tesla MRI was independently reported by 1 of 8 radiologists with varying levels of experience and scored on a 5-point Likert scale...
July 27, 2017: BJU International
https://www.readbyqxmd.com/read/28749065/concise-review-the-high-cost-of-high-tech-medicine-planning-ahead-for-market-access
#11
REVIEW
Dawn Driscoll, Stephanie Farnia, Panos Kefalas, Richard T Maziarz
Cellular therapies and other regenerative medicines are emerging as potentially transformative additions to modern medicine, but likely at a staggering financial cost. Public health care systems' budgets are already strained by growing and aging populations, and many private insurer's budgets are equally stretched. The current systems that most payers employ to manage their cash flow are not structured to absorb a sudden onslaught of very expensive prescriptions for a large portion of their covered population...
August 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28748971/follicular-dendritic-cell-sarcoma-of-the-head-and-neck-literature-review-and-report-of-the-tonsil-occurrence-in-a-ugandan-patient
#12
I Pecorella, T R Okello, G Ciardi, E Ochola, M D Ogwang
We report a case of follicular dendritic cell sarcoma (FDCS) in a 60-year-old Ugandan female who presented with a 6-year history of a progressive left sided tonsillary mass. General systemic examination was unrevealing and the patient underwent left tonsillectomy. She was subsequently lost to follow-up. Grossly, the mass measured 6 cm in diameter and had a mottled appearance due to tissue microhaemorrhages. Markers specific for follicular dendritic cell differentiation (CD21, CD35 and CD23), p53 and EGFR were expressed on immunohistochemical analysis...
June 2017: Pathologica
https://www.readbyqxmd.com/read/28748909/von-hippel-lindau-disease-when-neurosurgery-meets-nephrology-ophthalmology-and-genetics
#13
Francesco Signorelli, Giovanni Piscopo, Sophie Giraud, Silvana Guerriero, Antonio Laborante, Maria E Latronico, Gennaro Chimenti, Rodolfo Maduri, Domenico Chirchiglia, Angelo Lavano, Jacques Guyotat, Giovanni Alessio, Loreto Gesualdo
INTRODUCTION: Von Hippel-Lindau (VHL) disease is a dominantly inherited condition associated with tumors in multiple organs, whose treatment requires heightened multidisciplinary teamwork. Therefore, a document summarizing all the pertinent knowledge is needed to enhance coordination of care. EVIDENCE ACQUISITION: A systematic review of the literature from the Medline, Embase and Cochrane Central databases was performed. From 1970 to 2017, all articles meeting specific inclusion criteria were included by at least one specialist physician for each field...
July 26, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28748894/collagenofibrotic-collagen-type-iii-glomerulopathy-in-association-with-diabetic-nephropathy
#14
Khaled O Alsaad, Burhan Edrees, Khawla A Rahim, Abdulkareem Alanazi, Muawia Ahmad, Noura Aloudah
Collagenofìbrotic (collagen type III) glomerulopathy (CG) is a rare nonimmune-mediated glomerular disease. It is characterized by massive deposition of organized collagen type III fibers, which is localized in the mesangial and subendothelial glomerular areas and associated with increased serum levels of procollagen type III peptide. Association with systemic diseases and malignancies is extremely rare. Herein, we present a case of a nine-year-old girl, known case of type I diabetes mellitus, who presented with fever, nephrotic range proteinuria, generalized edema, and hypertension...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748881/predictive-factors-of-mortality-in-a-tunisian-cohort-with-systemic-lupus-erythematosus
#15
Amel Harzallah, Hayet Kaaroud, Mariem Hajji, Ikram Mami, Rim Goucha, Fethi Ben Hamida, Samia Barbouch, Taieb Ben Abdallah
Mortality in systemic lupus erythematosus (SLE) has decreased with the advent of immunosuppressive therapy and the development of hemodialysis. This study aims to evaluate the survival rate, factors of poor prognosis, and causes of death in SLE in a Tunisian series. The records of all SLE patients followed up in a single center during 1974-2014 were reviewed. The causes of death were identified. Prognostic factors of survival were analyzed by multivariate analysis using the comparison of the survival rates by the log-rank test...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748860/current-nondopaminergic-therapeutic-options-for-motor-symptoms-of-parkinson-s-disease
#16
REVIEW
Juan-Juan Du, Sheng-Di Chen
OBJECTIVE: The aim of this study was to summarize recent studies on nondopaminergic options for the treatment of motor symptoms in Parkinson's disease (PD). DATA SOURCES: Papers in English published in PubMed, Cochrane, and Ovid Nursing databases between January 1988 and November 2016 were searched using the following keywords: PD, nondopaminergic therapy, adenosine, glutamatergic, adrenergic, serotoninergic, histaminic, and iron chelator. We also reviewed the ongoing clinical trials in the website of clinicaltrials...
August 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28748641/eaaci-guidelines-on-allergen-immunotherapy-hymenoptera-venom-allergy
#17
Gunter J Sturm, Eva-Maria Varga, Graham Roberts, Holger Mosbech, M Beatrice Bilò, Cezmi A Akdis, Darío Antolín-Amérigo, Ewa Cichocka-Jarosz, Radoslaw Gawlik, Thilo Jakob, Mitja Kosnik, Joanna Lange, Ervin Mingomataj, Dimitris I Mitsias, Markus Ollert, Joanna N G Oude Elberink, Oliver Pfaar, Constantinos Pitsios, Valerio Pravettoni, Franziska Ruëff, Betül Ayşe Sin, Ioana Agache, Elizabeth Angier, Stefania Arasi, Moises A Calderón, Montserrat Fernandez-Rivas, Susanne Halken, Marek Jutel, Susanne Lau, Giovanni B Pajno, Ronald van Ree, Dermot Ryan, Otto Spranger, Roy Gerth van Wijk, Sangeeta Dhami, Hadar Zaman, Aziz Sheikh, Antonella Muraro
Hymenoptera venom allergy is a potentially life-threatening allergic reaction following a honeybee, vespid or ant sting. Systemic allergic sting reactions have been reported in up to 7.5% of adults and up to 3.4% of children. They can be mild and restricted to the skin or moderate-to-severe with a risk of life-threatening anaphylaxis. Patients should carry an emergency kit containing an adrenaline autoinjector, H1 -antihistamines, and corticosteroids depending on the severity of their previous sting reaction(s)...
July 27, 2017: Allergy
https://www.readbyqxmd.com/read/28748570/lichen-planopilaris-in-a-latin-american-chilean-population-demographics-clinical-profile-and-treatment-experience
#18
F Mardones, J Shapiro
BACKGROUND: Lichen planopilaris (LPP) is characterized by lymphocytic infiltrate, fibrosis and potential destruction of the hair follicle. Demographic and clinical studies in LPP are limited, and racial differences have not been thoroughly investigated. AIM: To analyse epidemiological data and clinical profiles of Chilean adults with LPP, and report on the treatments used. METHODS: This was a retrospective review of medical records and clinical follow-up of Chilean adults with a clinical and histopathological diagnosis of LPP...
July 27, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28748514/a-systemic-review-and-meta-analysis-of-the-clinical-efficacy-and-safety-of-total-glucosides-of-peony-combined-with-methotrexate-in-rheumatoid-arthritis
#19
Zhi-Tao Feng, Juan Xu, Guo-Chao He, San-Jin Cai, Juan Li, Zhi-Gang Mei
To assess the efficacy and safety of the combination of total glucoside of peony (TGP) and methotrexate (MTX) for the treatment of rheumatoid arthritis (RA). Randomized controlled trial (RCT) data on the traditional Chinese active component TGP combined with MTX vs. MTX alone for the treatment of RA was collected by searching the Pubmed, Embase, Cochrane Library, CNKI, VIP Journals database, and Wanfang database up to February 2017. Study selection, data extraction, data synthesis, and data analyses were performed according to the Cochrane standards...
July 27, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28748369/classical-experiments-in-whole-body-metabolism-closed-circuit-respirometry
#20
REVIEW
Bruno Archiza, Joseph F Welch, A William Sheel
As part of a series of reviews aimed at providing historical context to the study of whole-body metabolism, this article focuses on the technique of closed-circuit respirometry. Developed by nineteenth century physiologists Henri-Victor Regnault and Jules de Reiset, a constant-pressure closed-circuit calorimeter capable of measuring oxygen consumption and carbon dioxide production in small animals became the framework for future experiments on whole-body metabolism in humans. The volume-loss and volume-replenishment techniques can be used to indirectly assess energy expenditure using an oxygen reservoir; spirometers are simplistic in design but difficult to operate...
July 26, 2017: European Journal of Applied Physiology
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