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I E Timina, N N Askerova, G G Karmazanovskiĭ, I I Piatkova, A E Zotikov
BACKGROUND: The introduction into clinical practice of contrast-enhanced ultrasonographic examination made it possible to assess patency of tibial arteries and perfusion of crural muscles in patients with occlusive lesions of lower-limb arteries. These findings are important for planning optimal treatment policy and assessing efficacy of operative or medicamentous treatment. OBJECTIVE: The study was aimed at investigating a possibility of contrast-enhanced ultrasound examination for assessment of patency of tibial arteries and quantitative assessment of perfusion of crural muscles in patient with occlusive lesions of lower-limb arteries...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Tamas Csipo, Gabor A Fulop, Agnes Lipecz, Stefano Tarantini, Tamas Kiss, Priya Balasubramanian, Anna Csiszar, Zoltan Ungvari, Andriy Yabluchanskiy
Obesity is one of the major risk factors for cardiovascular diseases and its prevalence is increasing in all age groups, with the biggest impact observed in middle-aged and older adults. A critical mechanism by which obesity promotes vascular pathologies in these patients involves impairment of endothelial function. While endothelial dysfunction in large vessels promotes atherogenesis, obesity-induced microvascular endothelial dysfunction impairs organ perfusion and thereby is causally related to the pathogenesis of ischemic heart disease, chronic kidney disease, intermittent claudication, exercise intolerance, and exacerbates cognitive decline in aging...
June 18, 2018: GeroScience
Mathew Wooster, Paul Armstrong, Martin Back
OBJECTIVE: Maintenance of pelvic circulation has been connected to reduced risks of ischemic colitis, buttock claudication, erectile dysfunction, and spinal cord ischemia during the treatment of extensive aorto-iliac aneurysmal disease. We evaluate the mid to late follow up of a cohort of patients treated using one preservation technique, the endovascular external (EIA) to internal (IIA) iliac artery bypass. METHODS: All patients undergoing elective retrograde EIA-IIA endovascular bypass at a single institution were retrospectively reviewed over a ten-year period from 2006-2016...
June 13, 2018: Annals of Vascular Surgery
Rosario Maugeri, Luigi Basile, Carlo Gulì, Aurelia Banco, Giovanna Giordano, Antonella Giugno, Francesca Graziano, Roberto Giuseppe Giammalva, Domenico Gerardo Iacopino
BACKGROUND:  Lumbar spinal stenosis (LSS) is a narrowing of the spinal canal due to spinal degeneration, and its main clinical symptom is neurogenic claudication. Surgical treatment is pursued for patients who do not improve with conservative care. Patients with symptomatic LSS who also have significant medical comorbidities, although clearly in need of intervention, are unattractive candidates for traditional open lumbar decompressive procedures. Thus it is important to explore minimally invasive surgical techniques to treat select patients with LSS...
June 14, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
Diaa-Eldin Taha, Ahmed A Shokeir, Omar A Aboumarzouk
Objective: To establish the current evidence and assess the effectiveness and safety of selective transarterial embolisation (STE) to control intractable bladder haemorrhage (IBH). Materials and methods: With a rise in the use of STE for the treatment of IBH, a systematic review was performed according to the Cochrane reviews guidelines and in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. Results: The literature search yielded 38 studies, of which 11 were excluded because of irrelevance of data...
June 2018: Arab Journal of Urology
Carolina A Ferreira, Reinier Hernandez, Yunan Yang, Hector F Valdovinos, Jonathan W Engle, Weibo Cai
Peripheral Arterial Disease (PAD) is a chronic occlusion of lower-extremity arteries distal to the aortic bifurcation attributable to atherosclerosis. PAD is associated with an elevated risk of morbidity and mortality as well as of deterioration of the quality of life with claudication and chronic leg ischemia being the most frequent complications. Therapeutic angiogenesis is a promising therapeutic strategy that aims to restore the blood flow to the ischemic limb. In this context, assessing the efficacy of pro-angiogenic treatment using a reliable non-invasive imaging technique would greatly benefit the implementation of this therapeutic approach...
June 11, 2018: Molecular Pharmaceutics
Patrick Björkman, Tommi Auvinen, Harri Hakovirta, Pekka Romsi, Johanna Turtiainen, Hannu Manninen, Maarit Venermo, Kimmo Lappalainen, Anders Albäck, Antti Korpela, Kimmo Mäkinen, Petri Saari, Jukka Perälä
INTRODUCTION: Claudication and critical limb threatening ischemia (CLTI) are significant causes of mortality in the elderly. The gold standard of superficial femoral artery (SFA) revascularization is thus far considered to be the femoropopliteal bypass. The aim of this study was to compare mid-term patency between drug-eluting stents (DES) and prosthetic bypass grafts (BSX). Studies have reported comparable results for both methods. MATERIALS AND METHODS: 46 patients with claudication or rest pain due to a 5-25 cm SFA-occlusion were randomized between DES and BSX...
June 7, 2018: Annals of Vascular Surgery
Line Ea Hemstra, Anders Schlosser, Jes Sanddal Lindholt, Grith L Sorensen
BACKGROUND: Symptomatic peripheral artery disease (PAD) is an atherosclerotic occlusive disease affecting the lower extremities. The cause of symptomatic PAD is atherosclerosis, vascular dysfunctions, impaired angiogenesis and neointima formation. Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein, which is highly expressed in the heart and arteries and recently introduced as a potential mediator of pathological vascular remodeling and neointima formation. We aimed to investigate the relationship between serum MFAP4 (sMFAP4) and symptomatic PAD outcomes...
June 8, 2018: Journal of Translational Medicine
Thomas Troëng, Agneta Bergqvist, David Bergqvist
Neonatal aortic bifurcation thrombosis can cause occlusion of iliac arteries causing abnormal pelvic vasculature and claudication in childhood. A bifurcation graft normalizes the perfusion of the legs but not of the pelvis. In a girl, this does not preclude successful pregnancies in adult life. It has not been reported before.
June 2018: Clinical Case Reports
Peixian Gao, Dianning Dong, Le Yang, Hai Yuan, Mo Wang, Jingyong Zhang, Zhenyue Zhong, Shiyi Zhang, Xing Jin, Xuejun Wu
Purpose Isolated iliac artery aneurysms are the relatively uncommon condition. This study aims to evaluate the technical issues and clinical outcomes of endovascular repair in a cohort of isolated iliac artery aneurysms treated. Methods We retrospectively reviewed 22 consecutive patients with isolated iliac artery aneurysms between December 2006 and September 2016. Iliac artery aneurysms were treated in one of the three ways: (1) standard bifurcated aortic stent graft placement with limb extension; (2) coverage of iliac artery aneurysms with covered stent grafts; and (3) embolization of the arterial branches distal to the aneurysms with coils or vascular plugs...
January 1, 2018: Vascular
Brian J Schiro, Ripal T Gandhi, Constantino S Peña, Adam R Geronemus, Alex Powell, James F Benenati
Common iliac artery aneurysms (CIAAs) pose a challenge in endovascular aneurysm repair. Aneurysm repair of CIAA traditionally requires embolization of the ipsilateral hypogastric artery (HA). Symptoms of buttock claudication and more feared complications of pelvic ischemia make HA preservation an appealing addition to aneurysm repair. In this review, we discuss various methods of CIAA repair with devices specifically designed for aneurysm repair and other custom techniques of HA preservation.
April 2018: Cardiovascular Diagnosis and Therapy
Faith Quenzer, Joel Stillings, Jacqueline Le
Aortoiliac occlusive disease (AOD) is a rare presentation of thrombosis of the abdominal aorta. Also known as Leriche syndrome, its classic description entails claudication of the buttocks, thighs, and calves, absent femoral pulses, and impotence. AOD risk factors include smoking, hypertension, hyperlipidemia, diabetes, chronic renal insufficiency, and hypercoagulopathy. Ischemic complications of gastrointestinal malperfusion, renal infarction, and paralysis secondary to spinal cord ischemia are also noted...
November 2017: Clinical practice and cases in emergency medicine
Si Si, Jonathan Golledge, Paul Norman, Mark Nelson, Derek Chew, Zanfina Ademi, Deepak L Bhatt, Gabriel P Steg, Christopher M Reid
BACKGROUND: Compared with other manifestations of cardiovascular disease, peripheral arterial disease (PAD) is under-diagnosed. This study aims to investigate the prevalence, risk profile and cardiovascular outcomes of undiagnosed PAD in Australian general practices. METHOD: A sub-study of the Australian Reduction of Atherothrombosis for Continued Health (REACH) Registry, a prospective cohort study of patients at high risk of atherothrombosis recruited from Australian general practices...
May 8, 2018: Heart, Lung & Circulation
Ui Jun Park, Hyoung Tae Kim, Young-Nam Roh
BACKGROUND/OBJECTIVE: This study aimed to investigate the outcomes of femoropopliteal interventions in relation to various influencing factors. METHODS: A retrospective review of 243 endovascular procedures for femoropopliteal atherosclerotic lesions on 243 limbs of 197 patients was performed. RESULTS: In patients with claudication, the TLR free rates at 1-, 3-, and 5-year intervals were 89.1%, 82.2%, and 78.9%, respectively. Amputation-free survival rates in the claudicants at 1-, 3-, and 5-year intervals were 95...
May 25, 2018: Asian Journal of Surgery
Yi Yuan, Tao Wang, Jun Yuan, Gangbo Qu, Pandeng Hao, Zhijiang Zeng, Bing Luo, Jiafu Yang
Objective: To evaluate the feasibility and effectiveness of percutaneous cannulated screw fixation for the treatment of Day type Ⅱ pelvic crescent fracture. Methods: The clinical data of 14 patients with Day type Ⅱ pelvic crescent fractures underwent closed reduction and percutaneous cannulated screw fixation between January 2009 and July 2016 were retrospectively analysed. There were 9 males and 5 females, aged 17-65 years (mean, 38 years). The causes of injury included traffic accident in 8 cases, falling from height in 3 cases, bruise injury in 3 cases; all were closed fractures...
February 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
Dong Hu, Yan Zhang, Xiaojun Liang, Yi Li, Hongmou Zhao
Objective: To evaluate the short-term effectiveness of talonavicular arthrodesis for Müller-Weiss disease. Methods: Between May 2013 and February 2015, 13 patients with Müller-Weiss disease were treated with talonavicular arthrodesis. There were 11 females and 2 males with an average age of 59 years (range, 42-67 years). The disease duration was 8-20 years (mean, 13 years). According to Maceira stage, there were 7 cases of stage Ⅲ, 6 cases of stage Ⅳ. The foot longitudinal arch height measured on weight-bearing X-ray films was (43...
December 1, 2017: Chinese Journal of Reparative and Reconstructive Surgery
Grzegorz Golunski, Anna Woziwodzka, Jacek Piosik
Background Pentoxifylline (PTX) is a drug commonly used in the treatment of intermittent claudication. However, numerous research groups report that PTX also may potentially be used in the anticancer therapy following one of the main trends in the nowadays medicine - combined anticancer therapy. Scope of Review Review concentrates on the reports revealing potential use of PTX in cancer treatment. Major Conclusions PTX is described to possess several properties which may be exploited in cancer treatment. The drug reportedly to not only have anticancer activity itself, but also increase cancer cells susceptibility to radiation therapy and, additionally, reduce long-term side effects of this therapy...
May 27, 2018: Current Pharmaceutical Biotechnology
Timme van Vuuren, Cee Wittens, Rick de Graaf
PURPOSE: To analyze whether primary venous stent placement into 1 dominant inflow vein peripheral to the common femoral vein (CFV) confluence is feasible. MATERIALS AND METHODS: Retrospective review was performed of 14 consecutive patients who underwent primary venous stent placement into veins peripheral to the CFV between 2013 and 2016. Mean patient age was 49 years; 6 (43%) patients were women. All patients had successful deep venous stent placement with brisk contrast flow through the stent...
May 23, 2018: Journal of Vascular and Interventional Radiology: JVIR
Theodosios Bisdas, Efthymios Beropoulis, Angeliki Argyriou, Giovanni Torsello, Konstantinos Stavroulakis
OBJECTIVES: The aim of this study was to assess the performance of the fluoropolymer-based paclitaxel-eluting stent (PES) in long femoropopliteal lesions. BACKGROUND: The new-generation fluoropolymer-based PES showed promising outcomes in short femoropopliteal lesions. The main feature of the stent is its controlled and sustained paclitaxel release over 12 months. However, the safety and efficacy of this technology in longer femoropopliteal lesions remain unclear...
May 28, 2018: JACC. Cardiovascular Interventions
Antonio Micari, Marianne Brodmann, Koen Keirse, Patrick Peeters, Gunnar Tepe, Martin Frost, Hong Wang, Thomas Zeller
OBJECTIVES: The IN.PACT Global Study is the largest prospective, multicenter, independently adjudicated trial to evaluate a paclitaxel drug-coated balloon in patients with lifestyle-limiting claudication and/or ischemic rest pain due to atherosclerotic disease of the femoropopliteal artery and includes complex lesions beyond what are typically included in randomized controlled trials. BACKGROUND: Randomized controlled trials have demonstrated the safety and efficacy of drug-coated balloons for the treatment of Trans-Atlantic Inter-Society Consensus Document II A and B lesions, but there is a need for large-scale prospective studies to evaluate a broader range of lesions...
May 28, 2018: JACC. Cardiovascular Interventions
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