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Breast cancer cell, microRNA

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https://www.readbyqxmd.com/read/29678577/mir-485-5p-suppresses-breast-cancer-progression-and-chemosensitivity-by-targeting-survivin
#1
Meng Wang, Wen-Run Cai, Ran Meng, Jiang-Rui Chi, Yun-Rui Li, Ao-Xiang Chen, Yue Yu, Xu-Chen Cao
Breast cancer is the most common cancer among women worldwide. Chemoresistance remains to be a considerable obstacle in breast cancer therapy and it is often involves dysregulation of a variety of microRNAs (miRNAs). miR-485-5p functions as a tumor suppressor in several types of human cancers. However, its role in breast cancer chemosensitivity have not been determined. In the present study, we demonstrated that overexpression of miR-485-5p suppresses breast cancer progression and enhances chemosensitivity both in vitro and in vivo...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29666469/a-p53-mir-30a-zeb2-axis-controls-triple-negative-breast-cancer-aggressiveness
#2
Alessandra di Gennaro, Valentina Damiano, Giulia Brisotto, Michela Armellin, Tiziana Perin, Antonella Zucchetto, Michela Guardascione, Herman P Spaink, Claudio Doglioni, B Ewa Snaar-Jagalska, Manuela Santarosa, Roberta Maestro
Inactivation of p53 contributes significantly to the dismal prognosis of breast tumors, most notably triple-negative breast cancers (TNBCs). How the relief from p53 tumor suppressive functions results in tumor cell aggressive behavior is only partially elucidated. In an attempt to shed light on the implication of microRNAs in this context, we discovered a new signaling axis involving p53, miR-30a and ZEB2. By an in silico approach we identified miR-30a as a putative p53 target and observed that in breast tumors reduced miR-30a expression correlated with p53 inactivation, lymph node positivity and poor prognosis...
April 17, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29662176/cancer-cell-secreted-exosomal-mir-105-promotes-tumour-growth-through-the-myc-dependent-metabolic-reprogramming-of-stromal-cells
#3
Wei Yan, Xiwei Wu, Weiying Zhou, Miranda Y Fong, Minghui Cao, Juan Liu, Xiaojing Liu, Chih-Hong Chen, Oluwole Fadare, Donald P Pizzo, Jiawen Wu, Liang Liu, Xuxiang Liu, Andrew R Chin, Xiubao Ren, Yuan Chen, Jason W Locasale, Shizhen Emily Wang
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and buffer the negative effects of environmental changes. Extracellular microRNAs (miRNAs) have recently been implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-cancer-secreted, extracellular-vesicle-encapsulated miR-105, which is induced by the oncoprotein MYC in cancer cells and, in turn, activates MYC signalling in cancer-associated fibroblasts (CAFs) to induce a metabolic program...
April 16, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29661250/isocitrate-dehydrogenase-1-snail-axis-dysfunction-significantly-correlates-with-breast-cancer-prognosis-and-regulates-cell-invasion-ability
#4
Wen-Shan Liu, Shih-Hsuan Chan, Hong-Tai Chang, Guan-Cheng Li, Ya-Ting Tu, Hui-Hwa Tseng, Ting-Ying Fu, Hui-Yu Chang, Huei-Han Liou, Luo-Ping Ger, Kuo-Wang Tsai
BACKGROUND: The isocitrate dehydrogenase (IDH) gene family expresses key functional metabolic enzymes in the Krebs cycle and mediates the epigenetic reprogramming, which serves as an important biomarker of breast cancer. However, the expression levels of the IDH protein and their biological function in human breast cancer remain largely unknown. METHODS: In this study, the clinical impact of IDH1 expression on the progression and prognosis of breast cancer was evaluated using immunohistochemistry assay (IHC) of the corresponding tumor-adjacent normal, ductal carcinoma in situ (DCIS), and invasive ductal carcinoma (IDC) tissues from 309 patients with breast ductal carcinoma...
April 16, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29620289/function-of-microrna%C3%A2-141-in-human-breast-cancer-through-cytotoxic-cd4-t-cells-regulated-by-map4k4-expression
#5
Qing Zhang, Huang Xin, Tang Fen
The present study investigated the anti‑cancer effect of microRNA (miRNA)‑141 on apoptosis rate of breast cancer cells and the possible underlying mechanism. In patients with breast cancer, the expression of miRNA‑141 was downregulated. Overexpression of miRNA‑141 reduced breast cancer cell growth, inhibited the expression of cyclooxygenase‑2 (COX‑2), prostaglandin E2 (PGE2) and tumor necrosis factor (TNF)‑α, and increased the expression levels of interleukin (IL)‑10. However, downregulation of miRNA‑141 resulted in upregulation of COX‑2, PGE2 and TNF‑α expression levels, and an inhibition of IL‑10...
March 28, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29620260/microrna%C3%A2-142%C3%A2-5p-modulates-breast-cancer-cell-proliferation-and-apoptosis-by-targeting-phosphatase-and-tensin-homolog
#6
Wenda Xu, Weixing Wang
A total of 60 breast cancer (BC) tissues and adjacent healthy tissues from patients who underwent surgery in Renmin Hospital of Wuhan University were collected for analysis in the present study. Results from reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) demonstrated that, compared with the adjacent healthy tissues, the expression levels of microRNA (miR)‑142‑5p were significantly elevated in BC tissues. Bioinformatics analysis was performed using TargetScan for the prediction of potential target sites that matched the seed region of miR‑142‑5p; phosphatase and tensin homolog (PTEN) exhibited the highest score and was selected for further analysis...
March 28, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29620238/mir-328-5p-inhibits-mda-mb-231-breast-cancer-cell-proliferation-by-targeting-rage
#7
Tingting Luo, Yueqiong Yan, Qiuxia He, Xiaoqian Ma, Wei Wang
MicroRNAs (miRNAs) are a class of short non-coding RNAs that play an important role in gene regulation and are critically involved in the pathogenesis and progression of human cancer. miR-328-5p has been reported to potentially act as a sensitising agent in breast cancer, but its other cellular functions and mechanisms remain unknown. The primary aim of the present study was to discover additional cellular functions and mechanisms of miR-328-5p in the breast cancer cell line MDA-MB-231. In the present study, miRNA microarray was used to find altered miRNAs...
April 4, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29620195/microrna-671-3p-inhibits-the-development-of-breast-cancer-a-study-based-on-in-vitro-experiments-in-house-quantitative-polymerase-chain-reaction-and-bioinformatics-analysis
#8
Dan-Dan Xiong, Hao Chen, Rong-Quan He, Ai-Hua Lan, Jin-Cai Zhong, Gang Chen, Zhen-Bo Feng, Kang-Lai Wei
MicroRNAs (miRNAs or miRs) are highly conserved small noncoding RNA molecules involved in gene regulation. An increasing number of studies have demonstrated that miRNAs act as oncogenes or antioncogenes in various types of cancer, including breast cancer (BC). However, the exact role of miR‑671‑3p in BC has not yet been reported. In the present study, in vitro experiments were implemented to explore the effects of miR‑671‑3p on the proliferation and apoptosis of BC cells, and reverse transcription‑quantitative polymerase chain reaction was conducted using in‑house clinical BC samples to address the expression level and clinical value of miR‑671‑3p in BC...
March 28, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29620157/glucocorticoid-receptor-overexpression-slightly-shifts-microrna-expression-patterns-in-triple-negative-breast-cancer
#9
Dominik Buschmann, Ricardo González, Benedikt Kirchner, Claudia Mazzone, Michael W Pfaffl, Gustav Schelling, Ortrud Steinlein, Marlene Reithmair
Triple-negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer with limited options for clinical intervention. As with many solid tumors, TNBC is known to promote invasiveness and metastasis by secreting extracellular vesicles (EVs) capable of modulating the behaviour of recipient cells. Recent investigations have demonstrated that high expression levels of glucocorticoid receptor (GR) in TNBC are linked to therapy resistance, higher recurrence rates and increased mortality. In addition to activating protein-coding genes, GR is also involved in the expression of short non-coding RNAs including microRNAs (miRNAs or miRs)...
March 27, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29620153/histone-deacetylase-inhibitors-alter-the-expression-of-molecular-markers-in-breast-cancer-cells-via-micrornas
#10
Yehui Shi, Yongsheng Jia, Weipeng Zhao, Liyan Zhou, Xiaojuan Xie, Zhongsheng Tong
Histone deacetylase inhibitors (HDACis) are able to suppress breast cancer cells in vitro and in vivo by altering the expression of estrogen receptor (ER), progesterone receptor (PR) or human epidermal growth factor receptor 2 (Her2/neu). Since HDACis can alter the expression of various microRNAs (miRNAs/miRs), the present study aimed to examine the role of miRNAs in the effects of HDACis on breast cancer cells. We first examined the mRNA expression of ER, PR, and Her2/neu using RT-PCR and the protein levels of ER, PR, and Her2/neu using western blot analysis in MDA-MB-231 and BT474 cells, after trichostatin A (TSA) or vorinostat (SAHA) treatment...
April 3, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29617668/pan-cancer-analysis-of-lncrna-regulation-supports-their-targeting-of-cancer-genes-in-each-tumor-context
#11
Hua-Sheng Chiu, Sonal Somvanshi, Ektaben Patel, Ting-Wen Chen, Vivek P Singh, Barry Zorman, Sagar L Patil, Yinghong Pan, Sujash S Chatterjee, Anil K Sood, Preethi H Gunaratne, Pavel Sumazin
Long noncoding RNAs (lncRNAs) are commonly dysregulated in tumors, but only a handful are known to play pathophysiological roles in cancer. We inferred lncRNAs that dysregulate cancer pathways, oncogenes, and tumor suppressors (cancer genes) by modeling their effects on the activity of transcription factors, RNA-binding proteins, and microRNAs in 5,185 TCGA tumors and 1,019 ENCODE assays. Our predictions included hundreds of candidate onco- and tumor-suppressor lncRNAs (cancer lncRNAs) whose somatic alterations account for the dysregulation of dozens of cancer genes and pathways in each of 14 tumor contexts...
April 3, 2018: Cell Reports
https://www.readbyqxmd.com/read/29617404/angiogenic-role-of-mir-20a-in-breast-cancer
#12
Gines Luengo-Gil, Enrique Gonzalez-Billalabeitia, Sergio Alejo Perez-Henarejos, Esther Navarro Manzano, Asuncion Chaves-Benito, Elena Garcia-Martinez, Elisa Garcia-Garre, Vicente Vicente, Francisco Ayala de la Peña
BACKGROUND: Angiogenesis is a key process for tumor progression and a target for treatment. However, the regulation of breast cancer angiogenesis and its relevance for clinical resistance to antiangiogenic drugs is still incompletely understood. Recent developments on the contribution of microRNA to tumor angiogenesis and on the oncogenic effects of miR-17-92, a miRNA cluster, point to their potential role on breast cancer angiogenesis. The aim of this work was to establish the contribution of miR-20a, a member of miR-17-92 cluster, to tumor angiogenesis in patients with invasive breast carcinoma...
2018: PloS One
https://www.readbyqxmd.com/read/29616111/microrna-425-is-downregulated-in-nasopharyngeal-carcinoma-and-regulates-tumor-cell-viability-and-invasion-by-targeting-hepatoma-derived-growth-factor
#13
Wenyan Zhu, Yongchi Ma, Xuqin Zhuang, Xin Jin
Nasopharyngeal carcinoma (NPC), which arises from the nasopharynx epithelium, is most common in Southeast Asia, particularly in Southern China. To date, a variety of microRNAs have been demonstrated to serve key functions in the progression and development of NPC. microRNA-425 (miR-425) has previously been reported to be frequently abnormally expressed in a number of different types of human cancer, including lung, gastric, cervical, breast and prostate cancer. However, to the best of our knowledge, the expression patterns, functions and underlying mechanisms of miR-425 in NPC remain largely unexplored...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29599320/microrna-96-promotes-tumor-invasion-in-colorectal-cancer-via-reck
#14
Yasuhito Iseki, Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shinji Matsutani, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: miR-96 is reported to inhibit reversion cysteine-rich Kazal motif (RECK), which is associated with tumor invasion, in solid cancer types (e.g. breast cancer, non-small cell lung cancer, esophageal cancer). The purpose of this study is to clarify whether miR-96 is similarly associated with tumor invasion in colorectal cancer. MATERIALS AND METHODS: We performed western blotting to investigate the expression of RECK when miR-96 mimics or inhibitors were transferred into HCT-116 colorectal cancer cells...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29599302/molecular-sequence-of-events-and-signaling-pathways-in-cerebral-metastases
#15
REVIEW
Jared B Cooper, Jennifer S Ronecker, Michael E Tobias, Avinash L Mohan, Virany Hillard, Raj Murali, Chirag D Gandhi, Meic H Schmidt, Meena Jhanwar-Uniyal
Brain metastases are the leading cause of morbidity and mortality among cancer patients, and are reported to occur in about 40% of cancer patients with metastatic disease in the United States of America. Primary tumor cells appear to detach from the parent tumor site, migrate, survive and pass through the blood brain barrier in order to establish cerebral metastases. This complex process involves distinct molecular and genetic mechanisms that mediate metastasis from these primary organs to the brain. Furthermore, an interaction between the invading cells and cerebral milieu is shown to promote this process as well...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29596308/ep4-as-a-therapeutic-target-for-aggressive-human-breast-cancer
#16
REVIEW
Mousumi Majumder, Pinki Nandi, Ahmed Omar, Kingsley Chukwunonso Ugwuagbo, Peeyush K Lala
G-protein-coupled receptors (GPCRs, also called seven-transmembrane or heptahelical receptors) are a superfamily of cell surface receptor proteins that bind to many extracellular ligands and transmit signals to an intracellular guanine nucleotide-binding protein (G-protein). When a ligand binds, the receptor activates the attached G-protein by causing the exchange of Guanosine-5'-triphosphate (GTP) for guanosine diphosphate (GDP). They play a major role in many physiological functions, as well as in the pathology of many diseases, including cancer progression and metastasis...
March 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29589844/predicting-cancer-cell-invasion-by-single-cell-physical-phenotyping
#17
Kendra D Nyberg, Samuel L Bruce, Angelyn V Nguyen, Clara K Chan, Navjot K Gill, Tae-Hyung Kim, Erica K Sloan, Amy C Rowat
The physical properties of cells are promising biomarkers for cancer diagnosis and prognosis. Here we determine the physical phenotypes that best distinguish human cancer cell lines, and their relationship to cell invasion. We use the high throughput, single-cell microfluidic method, quantitative deformability cytometry (q-DC), to measure six physical phenotypes including elastic modulus, cell fluidity, transit time, entry time, cell size, and maximum strain at rates of 102 cells per second. By training a k-nearest neighbor machine learning algorithm, we demonstrate that multiparameter analysis of physical phenotypes enhances the accuracy of classifying cancer cell lines compared to single parameters alone...
March 28, 2018: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/29575198/down-regulation-of-microrna-19b-in-hormone-receptor-positive-her2-negative-breast-cancer
#18
Elham Maleki, Kamran Ghaedi, Kahin Shahanipoor, Zana Karimi Kurdistani
miR-19b (miR-19b-3p) has been reported to be correlated with either favorable or unfavorable events in several cancers. However, no study has been conducted to evaluate the expression level of miR-19b in patients with breast cancer (BC). This study was aimed to investigate the expression level of miR-19b in human malignant and healthy breast tissues with histopathology of ER+/PR+/HER2-. We performed a miRNA real-time PCR to detect differential expression of miR-19b in 40 BC, including 17 BC with familial background and 23 BC without familial background, and 12 non-tumoral tissues...
April 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29570270/cascade-amplification-mediated-in-situ-hot-spot-assembly-for-microrna-detection-and-molecular-logic-gate-operations
#19
Sha Yu, Yingying Wang, Li-Ping Jiang, Sai Bi, Jun-Jie Zhu
MicroRNAs (miRNAs) play important roles in many biological processes and are associated with various diseases, especially cancers. Combination of technological developments such as nanomaterials, functional enzyme-mediated reactions, and DNA nanotechnology holds great potential for high-performance detection of miRNAs in molecular diagnostic systems. In this work, we have fabricated a cascade signal amplification platform through integrating duplex-specific nuclease (DSN)-assisted target recycling with catalytic hairpin assembly (CHA) reaction for the detection of microRNA-141 (miR-141)...
March 23, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29567542/microrna-132-and-microrna-212-mediate-doxorubicin-resistance-by-down-regulating-the-pten-akt-nf-%C3%AE%C2%BAb-signaling-pathway-in-breast-cancer
#20
Manxin Xie, Ziyi Fu, Jianxiang Cao, Yuan Liu, Jie Wu, Qing Li, Yun Chen
Breast cancer is a serious health problem worldwide. Acquisition of multi-drug resistance (MDR) during the treatment of breast cancer is still considered a major clinical obstacle. Despite the biological functions of miRNAs becoming increasingly apparent, the function of miRNAs in regulating drug resistance of breast cancer remains under investigation. Quantitative real-time PCR (qRT-PCR) was used to quantify the expression of miR-132/-212 (miR-132 and miR-212) in doxorubicin (DOX)-resistant and -sensitive breast cancer tumors and cells...
March 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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