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Sara P Myers, Esmaeel R Dadashzadeh, Jessica Cheung, Louis Alarcon, Matthew Kutcher, Joshua B Brown, Matthew D Neal
BACKGROUND: Rivaroxaban has gained popularity as an anticoagulant (AC) for stroke prevention in nonvalvular atrial fibrillation (afib) and venous thromboembolism (VTE). Although adverse bleeding events are associated with all AC, lack of point of care testing to measure the effect of rivaroxaban in emergent situations has contributed to perceived increased risk amongst physicians. METHODS: To describe a single center experience with trauma and emergency general surgery (EGS) patients taking rivaroxaban and evaluate outcomes compared with patients taking warfarin using a propensity score analysis...
December 31, 2016: Journal of Trauma and Acute Care Surgery
Antoine Da Costa, Jean Baptiste Guichard, Nicolas Maillard, Cécile Romeyer-Bouchard, Antoine Gerbay, Karl Isaaz
BACKGROUND: Catheter ablation of atrial fibrillation (AFib) primarily relies upon pulmonary vein isolation (PVI), but such procedures are associated with significant X-ray exposure. The newer Epoch system has been developed so as to enable more precise magnetic navigation whilst limiting X-ray exposure. OBJECTIVES: This study was aimed at quantifying both exposure time and X-ray reduction with the newer Epoch system compared to Niobe II during AFib ablation procedures...
December 22, 2016: International Journal of Cardiology
Gorman Ew, Perkel D, Dennis D, Yates J, Heidel Re, Wortham D
Background: Atrial fibrillation (Afib) patients are at an increased risk of stroke. Patients at moderate to high risk of stroke typically receive antithrombotics, placing them at an increased risk of bleeding. The HAS-BLED tool has been validated in Afib patients receiving warfarin for prediction of major bleeding events. Although HAS-BLED has been researched in patients receiving warfarin, this tool has not been validated with the novel anticoagulant rivaroxaban. Methods: The trial design was retrospective case-control approved by the Institutional Review Board at University of Tennessee Medical Center...
August 2016: Journal of Atrial Fibrillation
Dhanunjaya Lakkireddy Md, Andrea Natale Md
No abstract text is available yet for this article.
June 2016: Journal of Atrial Fibrillation
Allison Junell, Jason Thomas, Lauren Hawkins, Jiri Sklenar, Trevor Feldman, Charles A Henrikson, Larisa G Tereshchenko
BACKGROUND: Each encounter of asymptomatic individuals with the healthcare system presents an opportunity for improvement of cardiovascular disease (CVD) awareness and sudden cardiac death (SCD) risk assessment. ECG sign deep terminal negativity of the P wave in V1 (DTNPV1) was shown to be associated with an increased risk of SCD in the general population. OBJECTIVE: To evaluate association of DTNPV1 with all-cause mortality and newly diagnosed atrial fibrillation (AFib) in the large tertiary healthcare system patient population...
February 1, 2017: International Journal of Cardiology
Antoine Da Costa, Amandine Axiotis, Cécile Romeyer-Bouchard, Loucif Abdellaoui, Zahi Afif, Jean Baptiste Guichard, Antoine Gerbay, Karl Isaaz
INTRODUCTION: A lack of information about the feasibility and safety of leadless pacemaker (LPMs) exists in a fragile population of patients with limited venous anatomy access or conventional pacemaker (PM) contraindication. Accordingly, the goal of this prospective observational study was to report our experience with this new leadless technology in a subset of patients with contraindication or limited venous access. METHODS AND RESULTS: Between May 2015 and July 2016, 14 patients were consecutively included...
January 15, 2017: International Journal of Cardiology
Diem Tran, Jeffrey Perry, Jean-Yves Dupuis, George Wells
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
Tero Hurnanen, Eero Lehtonen, Mojtaba Jafari Tadi, Tom Kuusela, Tuomas Kiviniemi, Antti Saraste, Tuija Vasankari, Juhani Airaksinen, Tero Koivisto, Mikko Pankaala
In this paper, a novel method to detect atrial fibrillation from a seismocardiogram (SCG) is presented. The proposed method is based on linear classification of the spectral entropy and a heart rate variability index computed from the SCG. The performance of the developed algorithm is demonstrated on data gathered from 13 patients in clinical setting. After motion artefact removal, in total 119 minutes of AFib data and 126 minutes of sinus rhythm data were considered for automated atrial fibrillation detection...
November 4, 2016: IEEE Journal of Biomedical and Health Informatics
Seongseok Yun, Nicole D Vincelette, Utkarsh Acharya, Ivo Abraham
BACKGROUND: Clinical trials raised concern that ibrutinib may increase the risk of atrial fibrillation/flutter (Afib/Aflutter) and major bleeding. However, the association has not been statistically validated, and there is no consensus regarding optimal management of anticoagulation among patients receiving ibrutinib who develop Afib/Aflutter. We performed a systematic review and pooled analysis to precisely assess the risk of Afib/Aflutter and bleeding associated with ibrutinib treatment in patients with hematologic malignancies...
September 19, 2016: Clinical Lymphoma, Myeloma & Leukemia
Isabella Canavero, Anna Cavallini, Lucia Sacchi, Silvana Quaglini, Natale Arnò, Patrizia Perrone, Maria Luisa DeLodovici, Simona Marcheselli, Giuseppe Micieli
BACKGROUND: It has been widely reported that anticoagulants (ACs) are underused for primary and secondary prevention of ischemic stroke in patients with atrial fibrillation (AFib). Furthermore, precise evidence-based guidelines about the best timing for AC initiation after acute stroke are currently lacking. METHODS AND RESULTS: In this retrospective, observational study, we analyzed prescription trends in AFib patients with acute ischemic stroke who were hospitalized in four neurologic stroke units of our region (Lombardia, Italy)...
January 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
John D Hummel, Mark A Coppess, Jeffrey S Osborn, Raymond Yee, Jeffrey W H Fung, Ralph Augostini, Shelby Li, Douglas Hine, Jagmeet P Singh
BACKGROUND: Left ventricular lead (LVL) implant success rates have historically ranged between 70.5% and 95.5%. To date, there are few large studies that evaluate LVL implant success utilizing a single family of delivery catheters and leads. The Attain Success study was a prospective nonrandomized multicenter global study with the main objectives of assessing single-system LVL implant success and complication rates. METHODS: Patients undergoing cardiac resynchronization therapy implantation were eligible for enrollment...
November 2016: Pacing and Clinical Electrophysiology: PACE
Y Kokubo, M Watanabe, A Higashiyama, Y M Nakao, T Watanabe, M Takegami, K Kusamo, S Kamakura, Y Miyamoto
OBJECTIVE: Atrial fibrillation (AFib) is linked to increased risks of mortality and cardiovascular disease. There are several prospective studies examined the association of smoking and metabolic syndrome (Mets) with incident AFib in a general population. No study examined the combination of smoking and Mets on the AFib risk in a general population. We investigated whether the combination of smoking and Mets increased the risk of incident AFib in an urban Japanese population. DESIGN AND METHOD: The 6,901 Suita Study participants (30-84 years old) were initially free of AFib and prospectively followed up for incident AFib...
September 2016: Journal of Hypertension
S Omboni, W J Verberk
OBJECTIVE: Timely detection of atrial fibrillation (AF) may effectively prevent cardiovascular consequences. However, traditional diagnostic tools are either poorly reliable (pulse palpation) or not readily accessible (electrocardiogram, ECG) in the general practice. We tested whether an automatic oscillometric blood pressure (BP) monitor embedding an algorithm for AF detection might be effective for opportunistic screening of asymptomatic AF in the community. DESIGN AND METHOD: 220 consecutive subjects from an unselected sample of individuals of a small Italian community were screened using a Microlife WatchBP Office BP monitor with patented AFIB algorithm...
September 2016: Journal of Hypertension
Pamela J McCabe, Kristin Vickers Douglas, Debra L Barton, Christine Austin, Adriana Delgado, Holli A DeVon
Improving early detection and treatment of atrial fibrillation (AF) is critical because untreated AF is a major contributor to stroke and heart failure. We sought to generate knowledge about the feasibility of conducting a randomized controlled trial to test the effect of the Alert for AFib intervention on knowledge, attitudes, and beliefs about treatment-seeking for signs and symptoms of AF. Adults ≥65 years old (96% White) at risk for developing AF were randomized to receive the Alert for AFib intervention (n = 40) or an attention control session (n = 40)...
July 6, 2016: Western Journal of Nursing Research
Michael B Simmers, Banumathi K Cole, Martin L Ogletree, Zhu Chen, Yiming Xu, Ling-Jie Kong, Nigel Mackman, Brett R Blackman, Brian R Wamhoff
An experimental in vitro model of the hemodynamics that occur in atrial fibrillation (AFib) in the left atrial appendage (LAA) was developed to study changes in human endothelial cell thrombotic potential. We applied human-derived sinus rhythm and AFib hemodynamic shear stress patterns to primary human endothelial cells (ECs) in culture. We found that ECs exposed to AFib hemodynamics have increased thrombotic potential as measured by increased expression of pro-thrombotic gene markers and fibrin deposition on the endothelium...
July 2016: Thrombosis Research
Vishwanath Sivalingam, Basant K Patel
Amyloidoses are clinical disorders where deposition of β-sheet rich, misfolded protein aggregates called amyloid occurs in vital organs like brain, kidney, liver or heart etc. Aggregation of several proteins such as immunoglobulin light chain, fibrinogen Aα chain (FGA) and lysozyme have been found to be associated with renal amyloidosis. Fibrinogen amyloidosis (AFib) is predominantly familial and is associated with the deposition of mutant FGA amyloid, primarily in kidneys. Over ten substitution and frame-shift mutations in FGA have been identified from AFib patients...
August 2016: Biochimie
Stefano Omboni, Willem J Verberk
OBJECTIVE: Timely detection of atrial fibrillation (AF) may effectively prevent cardiovascular consequences. However, traditional diagnostic tools are either poorly reliable (pulse palpation) or not readily accessible (ECG) in general practice. We tested whether an automatic oscillometric blood pressure (BP) monitor embedded with an algorithm for AF detection might be effective for opportunistic screening of asymptomatic AF in the community. SETTING: A community-based screening campaign in an unselected population to verify the feasibility of AF screening with a Microlife WatchBP Office BP monitor with a patented AFIB algorithm...
April 12, 2016: BMJ Open
Oren K Fix, Peter G Stock, Brian K Lee, Merrill D Benson
No abstract text is available yet for this article.
June 2016: Amyloid: the International Journal of Experimental and Clinical Investigation
Celal Alagoz, Allon Guez, Andrew Cohen, John R Bullinga
Analysis of electrical activation patterns such as re-entries during atrial fibrillation (Afib) is crucial in understanding arrhythmic mechanisms and assessment of diagnostic measures. Spiral waves are a phenomena that provide intuitive basis for re-entries occurring in cardiac tissue. Distinct spiral wave behaviors such as stable spiral waves, meandering spiral waves, and spiral wave break-up may have distinct electrogram manifestations on a mapping catheter. Hence, it is desirable to have an automated classification of spiral wave behavior based on catheter recordings for a qualitative characterization of spatiotemporal electrophysiological activity on atrial tissue...
August 2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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