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Isabella Canavero, Anna Cavallini, Lucia Sacchi, Silvana Quaglini, Natale Arnò, Patrizia Perrone, Maria Luisa DeLodovici, Simona Marcheselli, Giuseppe Micieli
BACKGROUND: It has been widely reported that anticoagulants (ACs) are underused for primary and secondary prevention of ischemic stroke in patients with atrial fibrillation (AFib). Furthermore, precise evidence-based guidelines about the best timing for AC initiation after acute stroke are currently lacking. METHODS AND RESULTS: In this retrospective, observational study, we analyzed prescription trends in AFib patients with acute ischemic stroke who were hospitalized in four neurologic stroke units of our region (Lombardia, Italy)...
September 7, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
John D Hummel, Mark A Coppess, Jeffrey S Osborn, Raymond Yee, Jeffrey W H Fung, Ralph Augostini, Shelby Li, Douglas Hine, Jagmeet P Singh
BACKGROUND: Left ventricular lead (LVL) implant success rates have historically ranged between 70.5% and 95.5%. To date, there are few large studies that evaluate LVL implant success utilizing a single family of delivery catheters and leads. The Attain Success study was a prospective nonrandomized multicenter global study with the main objectives of assessing single-system LVL implant success and complication rates. METHODS: Patients undergoing cardiac resynchronization therapy implantation were eligible for enrollment...
August 23, 2016: Pacing and Clinical Electrophysiology: PACE
Y Kokubo, M Watanabe, A Higashiyama, Y M Nakao, T Watanabe, M Takegami, K Kusamo, S Kamakura, Y Miyamoto
OBJECTIVE: Atrial fibrillation (AFib) is linked to increased risks of mortality and cardiovascular disease. There are several prospective studies examined the association of smoking and metabolic syndrome (Mets) with incident AFib in a general population. No study examined the combination of smoking and Mets on the AFib risk in a general population. We investigated whether the combination of smoking and Mets increased the risk of incident AFib in an urban Japanese population. DESIGN AND METHOD: The 6,901 Suita Study participants (30-84 years old) were initially free of AFib and prospectively followed up for incident AFib...
September 2016: Journal of Hypertension
S Omboni, W J Verberk
OBJECTIVE: Timely detection of atrial fibrillation (AF) may effectively prevent cardiovascular consequences. However, traditional diagnostic tools are either poorly reliable (pulse palpation) or not readily accessible (electrocardiogram, ECG) in the general practice. We tested whether an automatic oscillometric blood pressure (BP) monitor embedding an algorithm for AF detection might be effective for opportunistic screening of asymptomatic AF in the community. DESIGN AND METHOD: 220 consecutive subjects from an unselected sample of individuals of a small Italian community were screened using a Microlife WatchBP Office BP monitor with patented AFIB algorithm...
September 2016: Journal of Hypertension
Pamela J McCabe, Kristin Vickers Douglas, Debra L Barton, Christine Austin, Adriana Delgado, Holli A DeVon
Improving early detection and treatment of atrial fibrillation (AF) is critical because untreated AF is a major contributor to stroke and heart failure. We sought to generate knowledge about the feasibility of conducting a randomized controlled trial to test the effect of the Alert for AFib intervention on knowledge, attitudes, and beliefs about treatment-seeking for signs and symptoms of AF. Adults ≥65 years old (96% White) at risk for developing AF were randomized to receive the Alert for AFib intervention (n = 40) or an attention control session (n = 40)...
July 6, 2016: Western Journal of Nursing Research
Michael B Simmers, Banumathi K Cole, Martin L Ogletree, Zhu Chen, Yiming Xu, Ling-Jie Kong, Nigel Mackman, Brett R Blackman, Brian R Wamhoff
An experimental in vitro model of the hemodynamics that occur in atrial fibrillation (AFib) in the left atrial appendage (LAA) was developed to study changes in human endothelial cell thrombotic potential. We applied human-derived sinus rhythm and AFib hemodynamic shear stress patterns to primary human endothelial cells (ECs) in culture. We found that ECs exposed to AFib hemodynamics have increased thrombotic potential as measured by increased expression of pro-thrombotic gene markers and fibrin deposition on the endothelium...
July 2016: Thrombosis Research
Vishwanath Sivalingam, Basant K Patel
Amyloidoses are clinical disorders where deposition of β-sheet rich, misfolded protein aggregates called amyloid occurs in vital organs like brain, kidney, liver or heart etc. Aggregation of several proteins such as immunoglobulin light chain, fibrinogen Aα chain (FGA) and lysozyme have been found to be associated with renal amyloidosis. Fibrinogen amyloidosis (AFib) is predominantly familial and is associated with the deposition of mutant FGA amyloid, primarily in kidneys. Over ten substitution and frame-shift mutations in FGA have been identified from AFib patients...
August 2016: Biochimie
Stefano Omboni, Willem J Verberk
OBJECTIVE: Timely detection of atrial fibrillation (AF) may effectively prevent cardiovascular consequences. However, traditional diagnostic tools are either poorly reliable (pulse palpation) or not readily accessible (ECG) in general practice. We tested whether an automatic oscillometric blood pressure (BP) monitor embedded with an algorithm for AF detection might be effective for opportunistic screening of asymptomatic AF in the community. SETTING: A community-based screening campaign in an unselected population to verify the feasibility of AF screening with a Microlife WatchBP Office BP monitor with a patented AFIB algorithm...
2016: BMJ Open
Oren K Fix, Peter G Stock, Brian K Lee, Merrill D Benson
No abstract text is available yet for this article.
June 2016: Amyloid: the International Journal of Experimental and Clinical Investigation
Celal Alagoz, Allon Guez, Andrew Cohen, John R Bullinga
Analysis of electrical activation patterns such as re-entries during atrial fibrillation (Afib) is crucial in understanding arrhythmic mechanisms and assessment of diagnostic measures. Spiral waves are a phenomena that provide intuitive basis for re-entries occurring in cardiac tissue. Distinct spiral wave behaviors such as stable spiral waves, meandering spiral waves, and spiral wave break-up may have distinct electrogram manifestations on a mapping catheter. Hence, it is desirable to have an automated classification of spiral wave behavior based on catheter recordings for a qualitative characterization of spatiotemporal electrophysiological activity on atrial tissue...
August 2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Michael Markl, Daniel C Lee, Jason Ng, Maria Carr, James Carr, Jeffrey J Goldberger
OBJECTIVES: Left atrial (LA) 4-dimensional flow magnetic resonance imaging (MRI) was used to derive anatomic maps of LA stasis, peak velocity, and time-to-peak (TTP) velocity in patients with atrial fibrillation (AF) and to identify relationships between LA flow with LA volume and patient characteristics. MATERIALS AND METHODS: Four-dimensional flow MRI for the in vivo assessment of time-resolved 3-dimensional LA blood flow velocities was performed in 111 subjects: 42 patients with a history of AF and in sinus rhythm (AF-sinus), 39 patients with persistent AF (AF-afib), 10 young healthy volunteers (HVs), and 20 age-appropriate controls (CTRL)...
March 2016: Investigative Radiology
Kubilay Karabacak, Serkan Dilmen, Ismail Selcuk, Suat Doganci
No abstract text is available yet for this article.
October 2015: Interactive Cardiovascular and Thoracic Surgery
Sameh I Sersar
No abstract text is available yet for this article.
October 2015: Interactive Cardiovascular and Thoracic Surgery
Antonios Chryssos, Scott J Stroup, Melodie M Pifer, Mark Tawil, Carl G Conrad
As many as 25% of our cardiopulmonary bypass (CPB) patients have a diminished heparin response and fail to reach a therapeutic activated clotting time (ACT). We treat a majority of these patients with antithrombin III (ATryn®, recombinant antithrombin III [rhAT], rEVO Biologics). Our current CPB circuit uses Medtronic Carmeda® coating. We observed less post-operative bleeding in a number of patients treated with rhAT. We theorized that adding rhAT would allow patients with diminished heparin response to safely achieve a therapeutic ACT...
March 2015: Journal of Extra-corporeal Technology
Karen Kaiser, Wendy Y Cheng, Sally Jensen, Marla L Clayman, Andrew Thappa, Frances Schwiep, Anita Chawla, Jeffrey J Goldberger, Nananda Col, Jeff Schein
OBJECTIVE: Decision aids (DAs) are increasingly used to operationalize shared decision-making (SDM) but their development is not often described. Decisions about oral anticoagulants (OACs) for atrial fibrillation (AF) involve a trade-off between lowering stroke risk and increasing OAC-associated bleeding risk, and consideration of how treatment affects lifestyle. The benefits and risks of OACs hinge upon a patient's risk factors for stroke and bleeding and how they value these outcomes...
December 2015: Current Medical Research and Opinion
Christina A Spivey, Xianchen Liu, Yanru Qiao, Jack Mardekian, Robert B Parker, Hemant Phatak, Cristina Masseria, Sumesh Kachroo, Younos Abdulsattar, Junling Wang
OBJECTIVE: The objective of this study was to determine the association between warfarin discontinuation and stroke among patients with nonvalvular atrial fibrillation (NVAF). RESEARCH DESIGN AND METHODS: This was a retrospective, observational study of adult NVAF patients (≥ 18 years) who were on warfarin in the Truven MarketScan commercial claims and encounters and Medicare supplemental and coordination of benefits databases (1 January 2008 to 30 June 2012)...
November 2015: Current Medical Research and Opinion
Brian Marino, Abhishek Jaiswal, Seth Goldbarg, Gary L Bernardini, Todd Kerwin
BACKGROUND: The utility of transesophageal echocardiography (TEE) subsequent to a normal transthoracic echocardiogram (TTE) in older patients with an unexplained stroke is uncertain. METHODS: Two hundred sixty-three consecutive patients over the age of 50 years hospitalized with a clinical stroke confirmed with brain magnetic resonance imaging and a normal TTE were retrospectively analyzed. Patients with atrial fibrillation, atrial flutter, or any other causative reason for stroke were excluded...
February 2016: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
Yaroslav M Lohvinov, Kyrylo O Mikhaliev, Oleg J Zharinov
No abstract text is available yet for this article.
2015: Kardiologia Polska
Renée F A G de Bruijn, Jan Heeringa, Frank J Wolters, Oscar H Franco, Bruno H C Stricker, Albert Hofman, Peter J Koudstaal, M Arfan Ikram
IMPORTANCE: Atrial fibrillation (AF) has been suggested as a risk factor for dementia since it may lead to chronic cerebral hypoperfusion and stroke. However, longitudinal studies assessing the association between AF and dementia have shown inconsistent results. OBJECTIVE: To determine the effect of AF on the risk of developing dementia during 20 years of follow-up. DESIGN, SETTING, AND PARTICIPANTS: The association of prevalent and incident AF with incident dementia was assessed from July 6, 1989, to February 4, 2010, in 6514 dementia-free participants in the prospective population-based Rotterdam Study...
November 2015: JAMA Neurology
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