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Research Domain Criteria

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https://www.readbyqxmd.com/read/28342618/a-realist-synthesis-of-social-connectivity-interventions-during-transition-to-parenthood-the-value-of-relationships
#1
Claudine T Bennett, Judy L Buchan, Nicole Letourneau, Stuart G Shanker, Anne Fenwick, Brenda Smith-Chant, Cyndi Gilmer
BACKGROUND: Social connections are important during the transition to parenthood. A wide body of literature suggests that these connections enhance health and contribute to wellbeing. In the case of parents and families, social connections can influence child development. Nurses and public health agencies are in a unique position to advocate for resources and approaches to enhance social connectivity for parents during this important life transition. OBJECTIVES: The aim of this review was to identify the universal social connectivity interventions that work, and the conditions that foster social connections for parents and enhance child development...
April 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28337167/research-recommendations-for-improving-measurement-of-treatment-effectiveness-in-depression
#2
Kaloyan Kamenov, María Cabello, Mónica Nieto, Renaldo Bernard, Elisabeth Kohls, Christine Rummel-Kluge, José L Ayuso-Mateos
Background: Despite the steadily escalating psychological and economic burden of depression, there is a lack of evidence for the effectiveness of available interventions on functioning areas beyond symptomatology. Therefore, the main objective of this study was to give an insight into the current measurement of treatment effectiveness in depression and to provide recommendations for its improvement. Materials and Methods: The study was based on a multi-informant approach, comparing data from a systematic literature review, an expert survey with representatives from clinical practice (130), and qualitative interviews with patients (11) experiencing depression...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28336504/mhealth-for-clinical-decision-making-in-sub-saharan-africa-a-scoping-review
#3
Ibukun-Oluwa Omolade Adepoju, Bregje Joanna Antonia Albersen, Vincent De Brouwere, Jos van Roosmalen, Marjolein Zweekhorst
BACKGROUND: In a bid to deliver quality health services in resource-poor settings, mobile health (mHealth) is increasingly being adopted. The role of mHealth in facilitating evidence-based clinical decision-making through data collection, decision algorithms, and evidence-based guidelines, for example, is established in resource-rich settings. However, the extent to which mobile clinical decision support systems (mCDSS) have been adopted specifically in resource-poor settings such as Africa and the lessons learned about their use in such settings are yet to be established...
March 23, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28328043/csf-tau-and-the-csf-tau-abeta-ratio-for-the-diagnosis-of-alzheimer-s-disease-dementia-and-other-dementias-in-people-with-mild-cognitive-impairment-mci
#4
REVIEW
Craig Ritchie, Nadja Smailagic, Anna H Noel-Storr, Obioha Ukoumunne, Emma C Ladds, Steven Martin
BACKGROUND: Research suggests that measurable change in cerebrospinal fluid (CSF) biomarkers occurs years in advance of the onset of clinical symptoms (Beckett 2010). In this review, we aimed to assess the ability of CSF tau biomarkers (t-tau and p-tau) and the CSF tau (t-tau or p-tau)/ABeta ratio to enable the detection of Alzheimer's disease pathology in patients with mild cognitive impairment (MCI). These biomarkers have been proposed as important in new criteria for Alzheimer's disease dementia that incorporate biomarker abnormalities...
March 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28326147/q-sea-a-tool-for-quality-assessment-of-ethics-analyses-conducted-as-part-of-health-technology-assessments
#5
Anna Mae Scott, Björn Hofmann, Iñaki Gutiérrez-Ibarluzea, Kristin Bakke Lysdahl, Lars Sandman, Yvonne Bombard
Introduction: Assessment of ethics issues is an important part of health technology assessments (HTA). However, in terms of existence of quality assessment tools, ethics for HTA is methodologically underdeveloped in comparison to other areas of HTA, such as clinical or cost effectiveness. Objective: To methodologically advance ethics for HTA by: (1) proposing and elaborating Q-SEA, the first instrument for quality assessment of ethics analyses, and (2) applying Q-SEA to a sample systematic review of ethics for HTA, in order to illustrate and facilitate its use...
2017: GMS Health Technology Assessment
https://www.readbyqxmd.com/read/28320578/specific-cerebral-perfusion-patterns-in-three-schizophrenia-symptom-dimensions
#6
Katharina Stegmayer, Werner Strik, Andrea Federspiel, Roland Wiest, Stephan Bohlhalter, Sebastian Walther
Dimensional concepts such as the Research Domain Criteria initiative have been proposed to disentangle the heterogeneity of schizophrenia. One model introduced three neurobiologically informed behavioral dimensions: language, affectivity and motor behavior. To study the brain-behavior associations of these three dimensions, we investigated whether current behavioral alterations were linked to resting state perfusion in distinct brain circuits in schizophrenia. In total, 47 patients with schizophrenia spectrum disorders and 44 healthy controls were included...
March 17, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28316565/six-years-of-research-on-the-national-institute-of-mental-health-s-research-domain-criteria-rdoc-initiative-a-systematic-review
#7
REVIEW
Dean Carcone, Anthony C Ruocco
Six years have passed since the National Institute of Mental Health (NIMH) in the United States launched the Research Domain Criteria (RDoC) initiative. The RDoC introduces a framework for research on the biology of mental illness that integrates research findings across multiple levels of information. The framework outlines constructs that represent specific quantifiable dimensions of behavior (e.g., responses to acute threat, cognitive control) and corresponding units of analysis that can be used to study the constructs, beginning at the levels of genes, molecules, cells, circuits and physiology, and moving up to behaviors and self-reports...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28296264/a-clinician-administered-observation-and-corresponding-caregiver-interview-capturing-dsm-5-sensory-reactivity-symptoms-in-children-with-asd
#8
Paige M Siper, Alexander Kolevzon, A Ting Wang, Joseph D Buxbaum, Teresa Tavassoli
Sensory reactivity, including hyperreactivity, hyporeactivity, and sensation seeking, is a new criterion for autism spectrum disorder (ASD) in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). However, there is no consensus on how to reliably measure sensory reactivity, particularly in minimally verbal individuals. The current study is an initial validation of the Sensory Assessment for Neurodevelopmental Disorders (SAND), a novel clinician-administered observation and corresponding caregiver interview that captures sensory symptoms based on DSM-5 criteria for ASD...
March 11, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28295040/personal-utility-in-genomic-testing-a-systematic-literature-review
#9
REVIEW
Jennefer N Kohler, Erin Turbitt, Barbara B Biesecker
Researchers and clinicians refer to outcomes of genomic testing that extend beyond clinical utility as 'personal utility'. No systematic delineation of personal utility exists, making it challenging to appreciate its scope. Identifying empirical elements of personal utility reported in the literature offers an inventory that can be subsequently ranked for its relative value by those who have undergone genomic testing. A systematic review was conducted of the peer-reviewed literature reporting non-health-related outcomes of genomic testing from 1 January 2003 to 5 August 2016...
March 15, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28294468/memory-impairment-and-the-mediating-role-of-task-difficulty-in-patients-with-schizophrenia
#10
REVIEW
Kyrsten M Grimes, Anosha Zanjani, Konstantine K Zakzanis, C Psych
Using meta-analytic methods, we sought to synthesize the research literature on memory impairment in schizophrenia. Additionally, we compared performances across memory measures to determine if task difficulty (e.g., effortful encoding and retrieval versus non effortful encoding and retrieval) could account for variance across studies. Our primary measures of interest included the California Verbal Learning Test, Wechsler Memory Scale, Rey Auditory Verbal Learning Test, Hopkins Verbal Learning Test, Rey Osterrieth Complex Figure Test, and the Benton Visual Retention Test...
March 14, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28285495/pharmacological-interventions-for-acute-hepatitis-c-infection-an-attempted-network-meta-analysis
#11
REVIEW
Maria Kalafateli, Elena Buzzetti, Douglas Thorburn, Brian R Davidson, Emmanuel Tsochatzis, Kurinchi Selvan Gurusamy
BACKGROUND: Hepatitis C virus (HCV) is a single-stranded RNA (ribonucleic acid) virus that has the potential to cause inflammation of the liver. The traditional definition of acute HCV infection is the first six months following infection with the virus. Another commonly used definition of acute HCV infection is the absence of HCV antibody and subsequent seroconversion (presence of HCV antibody in a person who was previously negative for HCV antibody). Approximately 40% to 95% of people with acute HCV infection develop chronic HCV infection, that is, have persistent HCV RNA in their blood...
March 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28283488/quality-of-clinical-practice-guidelines-in-delirium-a-systematic-appraisal
#12
Shirley H Bush, Katie L Marchington, Meera Agar, Daniel H J Davis, Lindsey Sikora, Tammy W Y Tsang
OBJECTIVE: To determine the accessibility and currency of delirium guidelines, guideline summary papers and evaluation studies, and critically appraise guideline quality. DESIGN: Systematic literature search for formal guidelines (in English or French) with focus on delirium assessment and/or management in adults (≥18 years), guideline summary papers and evaluation studies.Full appraisal of delirium guidelines published between 2008 and 2013 and obtaining a 'Rigour of Development' domain screening score cut-off of >40% using the Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument...
March 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28277835/selective-targeting-of-epigenetic-reader-domains
#13
Holger Greschik, Roland Schüle, Thomas Günther
Epigenetic regulators including writers, erasers, and readers of chromatin marks have been implicated in numerous diseases and are therefore subject of intense academic and pharmaceutical research. While several small-molecule inhibitors targeting writers or erasers are approved drugs or which are being evaluated in clinical trials, the targeting of epigenetic readers has lagged. Proof-of-principle that epigenetic readers are also relevant drug targets was provided by landmark discoveries of selective inhibitors targeting the BET family of acetyl-lysine readers...
March 6, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28270327/temporal-sequencing-of-change-in-posttraumatic-cognitions-and-ptsd-symptom-reduction-during-prolonged-exposure-therapy
#14
Mandy J Kumpula, Kimberly Z Pentel, Edna B Foa, Nicole J LeBlanc, Eric Bui, Lauren B McSweeney, Kelly Knowles, Hannah Bosley, Naomi M Simon, Sheila A M Rauch
Prolonged exposure (PE) effectively reduces negative cognitions about self, world, and self-blame associated with posttraumatic stress disorder (PTSD), with changes in posttraumatic cognitions being associated with reductions in PTSD symptoms (Foa & Rauch, 2004). Further, recent research has demonstrated that cognitive change is a likely mechanism for PTSD symptom reduction in PE (Zalta et al., 2014). The present study examines temporal sequencing of change in three domains of posttraumatic cognitions (i.e...
March 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28267146/new-dimensions-and-new-tools-to-realize-the-potential-of-rdoc-digital-phenotyping-via-smartphones-and-connected-devices
#15
J Torous, J-P Onnela, M Keshavan
Mobile and connected devices like smartphones and wearable sensors can facilitate the collection of novel naturalistic and longitudinal data relevant to psychiatry at both the personal and population level. The National Institute of Mental Health's Research Domain Criteria framework offers a useful roadmap to organize, guide and lead new digital phenotyping data towards research discoveries and clinical advances.
March 7, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28256072/perceived-social-support-in-adults-with-autism-spectrum-disorder-and-attention-deficit-hyperactivity-disorder
#16
Sonia Alvarez-Fernandez, Hallie R Brown, Yihong Zhao, Jessica A Raithel, Somer L Bishop, Sarah B Kern, Catherine Lord, Eva Petkova, Adriana Di Martino
Perceived social support (PSS) has been related to physical and mental well-being in typically developing individuals, but systematic characterizations of PSS in autism spectrum disorder (ASD) are limited. We compared self-report ratings of the multidimensional scale of PSS (MSPSS) among age- and IQ-matched groups of adults (18-58 years) with cognitively high-functioning ASD (N = 41), or attention-deficit/hyperactivity disorder (ADHD; N = 69), and neurotypical controls (NC; N = 69). Accompanying group comparisons, we used machine learning random forest (RF) analyses to explore predictors among a range of psychopathological and socio-emotional variables...
March 3, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28255594/peer-assisted-learning-in-education-of-allied-health-professional-students-in-the-clinical-setting-a-systematic-review
#17
Samantha Sevenhuysen, Joanne Thorpe, Elizabeth Molloy, Jenny Keating, Terry Haines
Pressure on clinical educators to provide best practice education to growing student numbers is driving innovations in clinical education. Placing multiple students with a single clinical educator may increase capacity; however, little is known about the role and impact of peer-assisted learning (PAL) in these models. A systematic review of the literature from 1985 to 2014 was done to investigate the effectiveness of PAL amongst allied health professional students in clinical settings. Secondary aims were to investigate how PAL is defined and measured in this practice setting...
2017: Journal of Allied Health
https://www.readbyqxmd.com/read/28246078/return-to-play-criteria-after-hamstring-muscle-injury-in-professional-football-a-delphi-consensus-study
#18
Mattia Zambaldi, Ian Beasley, Alison Rushton
BACKGROUND: Hamstring muscle injury (HMI) is the most common injury in professional football and has a high re-injury rate. Despite this, there are no validated criteria to support return to play (RTP) decisions. AIM: To use the Delphi method to reach expert consensus on RTP criteria after HMI in professional football. METHODS: All professional football clubs in England (n=92) were invited to participate in a 3-round Delphi study. Round 1 requested a list of criteria used for RTP decisions after HMI...
February 28, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28241798/leveraging-the-ehr4cr-platform-to-support-patient-inclusion-in-academic-studies-challenges-and-lessons-learned
#19
Yannick Girardeau, Justin Doods, Eric Zapletal, Gilles Chatellier, Christel Daniel, Anita Burgun, Martin Dugas, Bastien Rance
BACKGROUND: The development of Electronic Health Records (EHRs) in hospitals offers the ability to reuse data from patient care activities for clinical research. EHR4CR is a European public-private partnership aiming to develop a computerized platform that enables the re-use of data collected from EHRs over its network. However, the reproducibility of queries may depend on attributes of the local data. Our objective was 1/ to describe the different steps that were achieved in order to use the EHR4CR platform and 2/ to identify the specific issues that could impact the final performance of the platform...
February 28, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28237133/reward-processing-and-mood-related-symptoms-an-rdoc-and-translational-neuroscience-perspective
#20
REVIEW
Robin Nusslock, Lauren B Alloy
BACKGROUND: Two objectives of the NIMH Research Domain Criteria (RDoC) initiative are to identify (a) mechanisms that are common to multiple psychiatric disorders, and (b) mechanisms that are unique to specific psychiatric symptoms, and that reflect markers of differential risk for these symptoms. With respect to these objectives, a brain-behavior dimension that has received considerable attention and that is directly relevant to the Positive Valence Systems domain of the RDoC initiative involves reward processing...
February 4, 2017: Journal of Affective Disorders
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