Cristine Marie Yde Ohki, Cecília Benazzato, Vanessa van der Linden, Julia V França, Carmen M Toledo, Rafael Rahal Guaragna Machado, Danielle Bastos Araujo, Danielle Bruna Leal Oliveira, Romulo S Neris, Iranaia Assunção-Miranda, Isis Nem de Oliveira Souza, Clara O Nogueira, Paulo Emilio Corrêa Leite, Hélio van der Linden, Claudia P Figueiredo, Edison Luiz Durigon, Julia R Clarke, Fabiele Baldino Russo, Patricia Cristina Baleeiro Beltrão-Braga
Zika virus (ZIKV) infection was first associated with Central Nervous System (CNS) infections in Brazil in 2015, correlated with an increased number of newborns with microcephaly, which ended up characterizing the Congenital Zika Syndrome (CZS). Here, we investigated the impact of ZIKV infection on the functionality of iPSC-derived astrocytes. Besides, we extrapolated our findings to a Brazilian cohort of 136 CZS children and validated our results using a mouse model. Interestingly, ZIKV infection in neuroprogenitor cells compromises cell migration and causes apoptosis but does not interfere in astrocyte generation...
February 24, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease