Marcos V S Fernandes, Nazareth N Rocha, Nathane S Felix, Gisele C Rodrigues, Luísa H A Silva, Mariana S Coelho, Ana Carolina F Fonseca, Ana Carolina G M Teixeira, Vera L Capelozzi, Paolo Pelosi, Pedro L Silva, John J Marini, Patricia R M Rocco
Increases in positive end-expiratory pressure (PEEP) or recruitment maneuvers may increase stress in lung parenchyma, extracellular matrix, and lung vessels; however, adaptative responses may occur. We evaluated the effects of PEEP on lung damage and cardiac function when increased abruptly, gradually, or more gradually in experimental mild/moderate acute respiratory distress syndrome (ARDS) induced by Escherichia coli lipopolysaccharide intratracheally. After 24 h, Wistar rats ( n = 48) were randomly assigned to four mechanical ventilation strategies according to PEEP levels: 1 ) 3 cmH2 O for 2 h (control); 2 ) 3 cmH2 O for 1 h followed by an abrupt increase to 9 cmH2 O for 1 h (no adaptation time); 3 ) 3 cmH2 O for 30 min followed by a gradual increase to 9 cmH2 O over 30 min then kept constant for 1 h (shorter adaptation time); and 4) more gradual increase in PEEP from 3 cmH2 O to 9 cmH2 O over 1 h and kept constant thereafter (longer adaptation time)...
February 1, 2022: Journal of Applied Physiology