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Solomiia Kozachok, Łukasz Pecio, Joanna Kolodziejczyk-Czepas, Svitlana Marchyshyn, Pawel Nowak, Jarosław Mołdoch, Wiesław Oleszek
The phytochemical investigation of the whole plant extracts of Herniaria glabra L. (Caryophyllaceae) led to the identification and isolation of four known flavonoids, one known and three undescribed maltol derivatives, and benzyl β-gentiobioside. The structures were established by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. For the first time in Herniaria genus, as well as in Caryophylaceae family the presence of apiorutin {quercetin 3-O-[(D-apio-β-d-furanosyl-(1 → 2)-O-[-α-l-rhamnopyranosyl-(1 → 6)]-β-d-glucopyranoside]} and licoagroside B {maltol 3-O-[6-O-(3-hydroxy-3-methylglutaroyl)]-β-d-glucopyranoside} were revealed...
May 18, 2018: Phytochemistry
Yangyang Liu, Beibei Yan, Juan Zhao, Lulu Wang, Yu Gu, Ping Chang, Yancai Wang
The poor penetration and low bioavailability are main challenges for transdermal drug delivery. Nanocrystals technology is an attractive method for water insoluble drug transdermal delivery, as the literature demonstrated that the penetration and bioavailability of the transdermal delivered water insoluble drugs was significantly enhanced and improved by the nanocrystals technology. Currently, the nanocrystals technology has been applied in transdermal delivery of cosmeceutical and for therapy skin diseases, such as diclofenac acid, tretinoin and rutin...
May 18, 2018: Current Drug Delivery
Syed Haris Omar, Christopher J Scott, Adam S Hamlin, Hassan K Obied
The focus of this study was on inhibition of enzymes involved in the pathogenesis Alzheimer's disease (AD) including prime amyloid beta (Aβ) producing enzyme (β-secretase: BACE-1) and disease progression enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), histone deacetylase (HDAC), and tyrosinase along with the catecholamine L-DOPA, by using olive biophenols. Here we report the strongest inhibition of BACE-1 from rutin (IC50 : 3.8 nM) followed by verbascoside (IC50 : 6.3 nM) and olive fruit extract (IC50 : 18 ng), respectively...
May 14, 2018: Fitoterapia
Wei Liu, Dongmei Wang, Xiaogai Hou, Yueqin Yang, Xian Xue, Qishi Jia, Lixia Zhang, Wei Zhao, Dongxue Yin
Traditional Chinese medicine (TCM) plays a very important role in the health system of China. The content and activity of active component are main indexes that evaluate the quality of TCM, however they may vary with environmental factors in their growing locations. In this study, effects of environmental factors on the contents of active components and antioxidant activity of Dasiphora fruticosa from the five main production areas of China were investigated. The contents of tannin, total flavonoid and rutin were determined and varied within the range of 7...
May 17, 2018: Chemistry & Biodiversity
Hye Jeong Yang, Min Jung Kim, Eun Seon Kang, Da Sol Kim, Sunmin Park
Red mulberry (Morus alba) fruit is rich in anthocyanins, and mulberry leaves are used by silk worms to make silk protein. We determined that the water and ethanol extract of mulberry fruit and silk amino acids accelerated ethanol degradation and suppressed temporal cognitive dysfunction in acute alcohol administered rats. The mechanism was explored in rats with acute oral administration of silk protein and mulberry fruit extracts. Rats were given 0.3 g of dextrin (control) and water extract (WMB) and ethanol extract of mulberry (EMB), silk protein hydrolysates (SKA), and a commercial product (positive‑control) based on body weight...
May 14, 2018: Molecular Medicine Reports
Jaehoon Jeong, Makram Essafi, Chulyeon Lee, Meriam Haoues, Mohamed Fethi Diouani, Hwajeong Kim, Youngkyoo Kim
Here we report that superoxide, one of the hazardous reactive oxygen species (ROS), can be quickly detected by flexible organic field-effect transistors (OFETs) with the polyphenol-embedded conjugated polymer micro-channels. Rutin, one of the abundant polyphenols found in a variety of plants, was employed as a sensing molecule and embedded in the poly(3-hexylthiophene) (P3HT) matrix. The rutin-embedded P3HT layers showed randomly distributed micro-domains, which became bigger as the rutin content increased...
April 27, 2018: Journal of Hazardous Materials
Mingya Ding, Zhen Li, Xie-An Yu, Dong Zhang, Jin Li, Hui Wang, Jun He, Xiu-Mei Gao, Yan-Xu Chang
This study aimed to clarify the difference between the effective compounds of raw and processed Farfarae flos using a network pharmacology-integrated metabolomics strategy. First, metabolomics data were obtained by ultra high-performance liquid chromatography-quadrupole-time of flight mass spectrometry (UHPLC-Q-TOF/MS). Then, metabolomics analysis was developed to screen for the influential compounds that were different between raw and processed Farfarae flos. Finally, a network pharmacology approach was applied to verify the activity of the screened compounds...
May 4, 2018: Journal of Pharmaceutical and Biomedical Analysis
Azzurra Stefanucci, Gokhan Zengin, Marcello Locatelli, Giorgia Macedonio, Chin-Kun Wang, Ettore Novellino, M Fawzi Mahomoodally, Adriano Mollica
Capparis spinosa L. (caper), is a traditionally used medicinal plant and widely studied for its biological properties. We aimed for the first time to compare the biological and phenolic fingerprints of C. spinosa buds, collected from Morocco, Turkey, and Italy. Phenolic compounds, fatty acids, and essential oils were profiled by chromatographic techniques. Enzymes inhibitory activities of different extracts were tested by spectrophotometric methods. Antioxidant capacity was evaluated by different assays including free radical scavenging, reducing power, metal chelating and phosphomolybdenum...
May 8, 2018: Food and Chemical Toxicology
José Luiz Carneiro da Rocha, Danielle Figuerêdo da Silva, Anne Ramos de Santana, Diego Mota da Costa, José Floriano Barêa Pastore, Clayton Queiroz Alves, Manoelito Coelho Santos Santos Junior, Hugo Neves Brandão
BACKGROUND: In Brazil, the Asemeia genus has 19 species (12 endemic) and 2 varieties (both endemic) and some of them are found in semi-arid Bahia. OBJECTIVE: The objective of this study was to quantitatively determine identified substances by HPLC-DAD in Asemeia ovata extracts and to predict their biological activities in silico. METHOD: The quantification method by HPLC-DAD has been validated according to the guidelines of the International Conference of Harmonization...
April 30, 2018: Computational Biology and Chemistry
Aliyu Muhammad, David Ebuka Arthur, Sanusi Babangida, Ochuko L Erukainure, Ibrahim Malami, Hadiza Sani, Aliyu Waziri Abdulhamid, Idayat Omoyemi Ajiboye, Ahmed Ariyo Saka, Nafisa Muhammed Hamza, Suleiman Asema, Zaharaddeen Muhammad Ado, Taibat Ishaq Musa
The aim of this study was to evaluate the potentials of rutin on 2,5-hexanedione-induced toxicities. Two successive phases were involved using in silico and in vivo approaches. The in silico was adopted for potential oral toxicity and docking. The in vivo was carried-out in two stages for two weeks; the ameliorative (stage 1, first week), preventive, and curative studies (stage 2, extended to second week). In stage 1, rats were divided into four groups of seven each (distilled water, 3% (v/v) 2,5-hexanedione, 10 mg/kg rutin, and co-administration)...
May 10, 2018: Drug and Chemical Toxicology
Liu Xianchu, Zheng Lan, Liu Ming, Mo Yanzhi
Rutin has a wide range of beneficial health properties in the amelioration of multi-organ injury owing to its various biological effects. The aim of this study was to investigate the effects of rutin on lipopolysaccharide (LPS)-induced heart injury and clarify its potential cardioprotective mechanism. The mouse model of heart injury was intraperitoneal infection with LPS, and rutin was orally administered for 8 consecutive days. One day after LPS injection, heart histopathology, cardiac marker enzymes and cardiac fibrosis related genes were determined to evaluate the cardioprotective effects of rutin...
2018: Journal of Toxicological Sciences
Eva Gatineau, Stéphanie Cluzet, Stéphanie Krisa, Isabelle Papet, Carole Migne, Didier Remond, Dominique Dardevet, Sergio Polakof, Tristan Richard, Laurent Mosoni
Little is still known about brain protein synthesis. In order to increase our knowledge of it, we aimed to modulate brain protein synthesis rates through aging, variations in nutritional state (fed state vs. fasted state), high sucrose diet and micronutrient supplementation. Four groups of 16 month-old male rats were fed for five months with a diet containing either 13% or 62% sucrose (wheat starch was replaced with sucrose), supplemented or not with rutin (5 g kg-1 diet), vitamin E (4×), A (2×), D (5×), selenium (10×) and zinc (+44%) and compared with an adult control group...
May 9, 2018: Food & Function
Maja Jeż, Wiesław Wiczkowski, Danuta Zielińska, Ireneusz Białobrzewski, Wioletta Błaszczak
The effect of high hydrostatic pressure (HHP) (450-550-650 MPa/5-10-15 min) on polyphenols profile of purée obtained from commercial tomato varieties (Maliniak, Cerise, Black Prince and Lima) was investigated. Individual polyphenols, total phenolic index (TPI) were quantified using a mass spectrometer (HPLC-MS/MS). Photochemiluminescence (PCLACW), cyclic voltammetry (CV) and ferric reducing antioxidant power (FRAP) assays were used to determine the antioxidant capacity of the hydrophilic extract. The results demonstrated that at certain processing conditions, HHP may enhance or decrease the nutritional quality of tomato purée...
September 30, 2018: Food Chemistry
AJing Ling, Xiaoping Li, Xinzhong Hu, Zhen Ma, Kunming Wu, Huiwen Zhang, Meng Hao, Sifan Wei
BACKGROUND: There is a growing interest in buckwheat germination regarding the improvement of its health benefits. The aims of this study were to evaluate the effects of germination on polyphenol compounds, antioxidant activity, and phenylalanine ammonia-lyase (PAL) gene expression in different tissues (cotyledon, hypocotyl, and radicle) of buckwheat sprouts during germination for 12 days, as well as to investigate their interactions. RESULTS: Total polyphenol and total flavonoid content, antioxidant activity, main polyphenol components, and PAL gene expression significantly increased during germination...
May 8, 2018: Journal of the Science of Food and Agriculture
Luchao Sun, Amit Rai, Megha Rai, Michimi Nakamura, Noriaki Kawano, Kayo Yoshimatsu, Hideyuki Suzuki, Nobuo Kawahara, Kazuki Saito, Mami Yamazaki
The three Forsythia species, F. suspensa, F. viridissima and F. koreana, have been used as herbal medicines in China, Japan and Korea for centuries and they are known to be rich sources of numerous pharmaceutical metabolites, forsythin, forsythoside A, arctigenin, rutin and other phenolic compounds. In this study, de novo transcriptome sequencing and assembly was performed on these species. Using leaf and flower tissues of F. suspensa, F. viridissima and F. koreana, 1.28-2.45-Gbp sequences of Illumina based pair-end reads were obtained and assembled into 81,913, 88,491 and 69,458 unigenes, respectively...
May 7, 2018: Journal of Natural Medicines
Alfonso Trezza, Vittoria Cicaloni, Piera Porciatti, Andrea Langella, Fabio Fusi, Simona Saponara, Ottavia Spiga
Background: ATP-sensitive inward rectifier potassium channels (Kir), are a potassium channel family involved in many physiological processes. KATP dysfunctions are observed in several diseases such as hypoglycaemia, hyperinsulinemia, Prinzmetal angina-like symptoms, cardiovascular diseases. Methods: A broader view of the KATP mechanism is needed in order to operate on their regulation, and in this work we clarify the structure of the Rattus norvegicus ATP-sensitive inward rectifier potassium channel 8 (Kir6...
2018: PeerJ
Sérgio Henrique Brabo de Sousa, Rafaella de Andrade Mattietto, Renan Campos Chisté, Ana Vânia Carvalho
This research aimed to evaluate 32 genotypes of Oenocarpus distichus fruits regarding the contents of total phenolic compounds, flavonoids, flavanols, monomeric anthocyanins, antioxidant capacity (ABTS and DPPH assays), and the phenolic compound profiles of the five genotypes that presented the highest yields of bioactive compounds. The genotypes were harvested in three different locations in Pará State, Northern Brazil, (Belém, São João do Araguaia and Marabá). Among the 32 genotypes, the highest bioactive compound contents and antioxidant capacity were found for three genotypes harvested in Belém (B-3, B-7 and B-8) and two harvested in São João do Araguaia (SJ-1 and SJ-4), and the total phenolic compounds varied from 131...
June 2018: Food Research International
Oroma Nwanodi
Nutraceuticals are important for healthy skin maintenance. Probiotics, phenolics, and vitamins are just a few of the nutraceuticals meant to potentially prevent and assist medical management of dermatologic conditions. Among these, probiotics, vitamin E, and green tea catechins may offer the broadest array of skin protective mechanisms with probiotics having the greatest clinical range. Probiotics’ amelioration of atopic dermatitis and opportunistic infections of skin burns has been targeted in recent research efforts...
May 4, 2018: Healthcare (Basel, Switzerland)
Sabitiu A Oyeleke, Abayomi M Ajayi, Solomon Umukoro, A O Aderibigbe, Olusegun George Ademowo
ETHNOPHARMACOLOGICAL RELEVANCE: The stem bark of Theobroma cacao L. have been used for the treatment of inflammation, toothache, measles and malaria in ethnomedicine. However, the anti-inflammatory activity of Theobroma cacao stem bark has not been fully elucidated. AIM: The anti-inflammatory activity of Theobroma cacao stem bark ethanol extract and its fractions was investigated in this study. MATERIALS AND METHODS: The anti-inflammatory effect of ethanol extract of Theobroma cacao stem bark (EETc) and its dichloromethane (DCMF), ethylacetate (EAF) and aqueous (AQF) fractions was investigated in erythrocytes membrane stabilizing assay and carrageenan-induced paw oedema...
May 4, 2018: Journal of Ethnopharmacology
Li Zhou, Xinmin Shi, Xiangmei Ren, Zhihong Qin
This study was aimed to assess the potential of Dioscorea (yam) leaves as a source of antioxidants. Microwave-assisted extraction (MAE) process was used to prepare the extracts. The phenolic compounds in Dioscorea leaves extracts were analyzed by HPLC-DAD-ESI-MS/MS method and the contents of major compounds were determined. Results indicated that a total of 17 phenolic compounds were separated identified by means of UV and mass spectra compared with authentic reference substances and/or reported values in the literature...
May 2018: Pakistan Journal of Pharmaceutical Sciences
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