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https://www.readbyqxmd.com/read/28095717/functional-constituents-of-wild-and-cultivated-goji-l-barbarum-l-leaves-phytochemical-characterization-biological-profile-and-computational-studies
#1
Andrei Mocan, Gökhan Zengin, Mario Simirgiotis, Michaela Schafberg, Adriano Mollica, Dan C Vodnar, Gianina Crişan, Sascha Rohn
Goji (Lycium barbarum L.) leaves are emphasized as a functional tea or as dietary supplements. The phenolic compound profile, antioxidant, enzyme inhibitory, antimicrobial, and antimutagenic activities of leaf extracts from two selected cultivars in comparison with wild-growing plants have been evaluated. HPLC-DAD/ESI-ToF-MS analysis revealed the presence of phenolic acids and flavonoids with chlorogenic acid and rutin being the dominant compounds in the cultivated plants, whereas rutin and kaempeferol-3-O-rutinoside for wild growing ones...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28090664/development-of-a-novel-dual-cd-mekc-system-for-the-systematic-flavonoid-fingerprinting-of-ligaria-cuneifolia-r-et-p-tiegh-loranthaceae-extracts
#2
Cecilia B Dobrecky, Sabrina A Flor, Paula G López, Marcelo L Wagner, Silvia E Lucangioli
The present work deals with the development and validation of a novel dual CD-MEKC system for the systematic flavonoid fingerprinting of Ligaria cuneifolia (R. et P.) Tiegh. -Loranthaceae- extracts. The BGE consisted of 20 mM pH 8.3 borate buffer, 50 mM SDS, a dual CD system based on the combination of 5 mM β-CD and 2% w/v S-β-CD, and 10% v/v methanol. The proposed method has been successfully applied to the comparative analysis of extracts from aerial parts and different hosts, geographical areas and extraction procedures in order to establish the flavonoid fingerprint of L...
January 16, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28069395/rutin-attenuates-doxorubicin-induced-cardiotoxicity-via-regulating-autophagy-and-apoptosis
#3
Yanyan Ma, Lifang Yang, Jipeng Ma, Linhe Lu, Xiaowu Wang, Jun Ren, Jian Yang
Doxorubicin as anticancer agent can cause dose-dependent cardiotoxicity and heart failure in the long term. Rutin as a polyphenolic flavonoid has been illustrated to protect hearts from diverse cardiovascular diseases. Its function is known to be related to its antioxidant and antiinflammatory activity which may regulate multiple cellular signal pathways. However, the role of rutin on doxorubicin-induced cardiotoxicity has yet to be discovered. In this study, we explored the protective role of rutin on doxorubicin-induced heart failure and elucidated the potential mechanisms of protective effects of rutin against cardiomyocyte death...
January 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28066109/cerebroprotective-activity-of-pentapetes-phoenicea-on-global-cerebral-ischemia-in-rats
#4
Koneru Naga Sravanthi, Nadendla Rama Rao
OBJECTIVES: The study was performed to evaluate the cerebroprotective activity of methanolic extract (ME) of Pentapetes phoenicea - a folk medicine used as anti-inflammatory and in central nervous system ailments. It has high phenolic and flavonoid contents including rutin. MATERIALS AND METHODS: Global cerebral ischemia was induced in male albino Wistar rats by temporary bilateral carotid artery occlusion (BCAO) for 30 min, followed by 4 h reperfusion. Groups of rats were pretreated for 10 days with 100, 200, and 400 mg/kg of ME of P...
November 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28056421/capparis-spinosa-leaves-extract-source-of-bioantioxidants-with-nephroprotective-and-hepatoprotective-effects
#5
Nizar Tlili, Anouar Feriani, Ezzeddine Saadoui, Nizar Nasri, Abdelhamid Khaldi
Capparis spinosa, Capparidaceae, is largely distributed all over the Mediterranean Basin and is traditionally used to treat many illnesses, such as liver and kidney diseases. The aim of the current study was to explore the antioxidant, nephroprotective and hepatoprotective effects of methanolic extract of Capparis spinosa leaves (MECS) associated with its phytochemical content. The levels of total phenolics, flavonoids and condensed tannins were 23.37mgGAE/g, 9.05mgQE/g and 9.35mgTAE/g, respectively. HPLC analysis revealed nine compounds, namely rutin, resveratrol, coumarin, epicatechin, luteolin, catechin, kaempferol, vanillic acid and gallic acid...
January 2, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28049156/rutin-ameliorates-obesity-through-brown-fat-activation
#6
Xiaoxue Yuan, Gang Wei, Yilin You, Yuanyuan Huang, Hyuek Jong Lee, Meng Dong, Jun Lin, Tao Hu, Hanlin Zhang, Chuanhai Zhang, Huiqiao Zhou, Rongcai Ye, Xiaolong Qi, Baiqiang Zhai, Weidong Huang, Shunai Liu, Wen Xie, Qingsong Liu, Xiaomeng Liu, Chengbi Cui, Donghao Li, Jicheng Zhan, Jun Cheng, Zengqiang Yuan, Wanzhu Jin
Increasing energy expenditure through activation of brown adipose tissue (BAT) is a critical approach to treating obesity and diabetes. In this study, rutin, a natural compound extracted from mulberry and a drug used as a capillary stabilizer clinically for many years without any side effects, regulated whole-body energy metabolism by enhancing BAT activity. Rutin treatment significantly reduced adiposity, increased energy expenditure, and improved glucose homeostasis in both genetically obese (Db/Db) and diet-induced obesity (DIO) mice...
January 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28049060/a-comparative-study-of-the-dynamic-accumulation-of-polyphenol-components-and-the-changes-in-their-antioxidant-activities-in-diploid-and-tetraploid-lonicera-japonica
#7
Dexin Kong, Yanqun Li, Mei Bai, Yali Deng, Guangxin Liang, Hong Wu
Polyploidization is an effective method to achieve a higher yield of secondary metabolism active ingredients in medicinal plants. Polyphenols are the main active substances that contribute to the antioxidant activity of Lonicera japonica. For studying on the effect of chromosome doubling and harvest time on the dynamic accumulation of the main active substances and antioxidant capabilities of L. japonica, the polyphenol composition contents (7 phenolic acids and 3 flavonoids) and the antioxidant capacity in buds and flowers of diploid and tetraploid L...
December 28, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28043362/rutin-can-replace-the-use-of-three-other-antioxidants-in-the-culture-medium-maintaining-the-viability-of-sheep-isolated-secondary-follicles
#8
T L B G Lins, A Y P Cavalcante, J M S Santos, V G Menezes, V R P Barros, R S Barberino, M É S Bezerra, T J S Macedo, M H T Matos
The present study evaluated the effect of addition of rutin alone or combined with other antioxidants (transferrin, selenium and ascorbic acid) present in the culture medium on the in vitro development of ovine isolated secondary follicles. After collection of the sheep ovaries, secondary follicles (200-230 μm) were isolated and cultured for 12 days in α-Minimal Essential Medium (α-MEM) supplemented with BSA, insulin, glutamine and hypoxanthine (α-MEM: antioxidant free-medium) or in this medium also added by transferrin, selenium and ascorbic acid (AO: base medium with antioxidants)...
February 2017: Theriogenology
https://www.readbyqxmd.com/read/28039787/topical-antiedematogenic-and-anti-inflammatory-effect-of-scutia-buxifolia-reissek-gel-and-stability-study
#9
Aline Augusti Boligon, Laís da Rosa Moreira, Mariana Piana, Marli Matiko Anraku de Campos, Sara Marchesan Oliveira
Scutia buxifolia Reissek (Rhamnaceae), popularly known in Brazil as "coronilha", is a plant species used in folk medicine for several disorders, including inflammation. However, no studies have been done with this species to confirm its topical anti-inflammatory action. In this study we evaluate the topical antiedematogenic and anti-inflammatory effects of the gel containing crude extract (CE) and the gel containing ethyl acetate (EtOAc) fraction of S. buxifolia on croton oil or UVB radiation-induced ear edema in mice, and perform gel stability study...
December 22, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28029227/physicochemical-antioxidant-and-cytotoxic-properties-of-xao-tam-phan-paramignya-trimera-root-extract-and-its-fractions
#10
Nguyen Van Tang, Jennette A Sakoff, Christopher J Scarlett
Xao tam phan (Paramignya trimera (Oliv.) Guillaum) has been used as a medicinal plant for cancer prevention and treatment in recent years. The objective of this study was to determine the physicochemical, antioxidant and cytotoxic properties of crude P. trimera root (PTR) extract and its fractions using methanol as a solvent and microwave-assisted extraction as an advanced technique for preparation of the PTR extract. The results showed that the PTR extract had high contents of saponins, phenolics, flavonoids and proanthocyanidins (7731...
December 28, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28029143/troxerutin-attenuates-enhancement-of-hepatic-gluconeogenesis-by-inhibiting-nod-activation-mediated-inflammation-in-high-fat-diet-treated-mice
#11
Zifeng Zhang, Xin Wang, Guihong Zheng, Qun Shan, Jun Lu, Shaohua Fan, Chunhui Sun, Dongmei Wu, Cheng Zhang, Weitong Su, Junwen Sui, Yuanlin Zheng
Recent evidence suggests that troxerutin, a trihydroxyethylated derivative of natural bioflavonoid rutin, exhibits beneficial effects on diabetes-related symptoms. Here we investigated the effects of troxerutin on the enhancement of hepatic gluconeogenesis in high-fat diet (HFD)-treated mice and the mechanisms underlying these effects. Mice were divided into four groups: Control group, HFD group, HFD + Troxerutin group, and Troxerutin group. Troxerutin was treated by daily oral administration at doses of 150 mg/kg/day for 20 weeks...
December 25, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28025998/in-vitro-screening-of-radioprotective-properties-in-the-novel-glucosylated-flavonoids
#12
Hao Yu, Jeremy S Haskins, Cathy Su, Allison Allum, Alexis H Haskins, Victoria A Salinas, Shigeaki Sunada, Taisuke Inoue, Yasushi Aizawa, Mitsuru Uesaka, Takamitsu A Kato
Novel glucosyl flavonoids are developed by the addition of glucose to naturally occurring flavonoids. Flavonoids are known antioxidants that possess radioprotective properties. In order to investigate the radioprotective properties of novel glucosyl flavonoids, in vitro DNA double-strand breaks (DSBs) analysis was carried out. In the present study, Quercetin, Naringenin, and Hesperetin groups of flavonoids included in the natural and novel glucosyl 13 flavonoids were investigated. Flavonoids were mixed with Lambda DNA, and subsequently exposed to gamma‑rays...
November 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28008812/anti-inflammation-properties-of-fruiting-bodies-and-submerged-cultured-mycelia-of-culinary-medicinal-higher-basidiomycetes-mushrooms
#13
Rao-Chi Chien, Lan-Min Lin, Yuan-Hua Chang, Yu-Chieh Lin, Pei-Hsuan Wu, Mikheil D Asatiani, Sophie-Gabrielle Wasser, Maxim Krakhmalnyi, Abed Agbarya, Solomon P Wasser, Jeng-Leun Mau
This research shows the phenolic composition and anti-inflammation properties of fruiting bodies and mycelia of 15 strains of 12 species of higher Basidiomycetes medicinal mushrooms. In this research, 15 extracts were prepared and their effects on inflammation-related mediators in RAW 264.7 cells were evaluated. In the extracts, amounts of total phenols ranged from 8.47 to 70.32 gallic acid equivalents mg/g and amounts of flavonoids ranged from 0.13 to 15.21 rutin equivalents mg/g. The production of nitric oxide, tumor necrosis factor-α, and interleukin-6 was decreased at different levels by these extracts, whereas the production of interleukin-10 was increased by 6 of the extracts...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28006731/selenite-modulates-the-level-of-phenolics-and-nutrient-element-to-alleviate-the-toxicity-of-arsenite-in-rice-oryza-sativa-l
#14
Reshu Chauhan, Surabhi Awasthi, Preeti Tripathi, Seema Mishra, Sanjay Dwivedi, Abhishek Niranjan, Shekhar Mallick, Pratibha Tripathi, Veena Pande, Rudra Deo Tripathi
Arsenic (As) contamination of paddy rice is a serious threat all over the world particularly in South East Asia. Selenium (Se) plays important role in protection of plants against various abiotic stresses including heavy metals. Moreover, arsenite (AsIII) and selenite (SeIV) can be biologically antagonistic due to similar electronic configuration and sharing the common transporter for their uptake in plant. In the present study, the response of oxidative stress, phenolic compounds and nutrient elements was analyzed to investigate Se mediated As tolerance in rice seedlings during AsIII and SeIV exposure in hydroponics...
December 19, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28004224/antioxidant-and-antiproliferative-effects-of-different-solvent-fractions-from-terminalia-belerica-roxb-fruit-on-various-cancer-cells
#15
Tapasree Basu, Sourav Panja, Nikhil Baban Ghate, Dipankar Chaudhuri, Nripendranath Mandal
Terminalia belerica Roxb. fruits have been previously reported against diabetes, ulcer, microbial problems and hepatotoxicity. The present study was aimed to investigate antioxidant and anticancer potential of sequentially fractionated hexane (TBHE), chloroform (TBCE), ethyl acetate (TBEE), butanol (TBBE) and water (TBWE) extracts from the 70% methanolic extract of T. belerica fruits. TBCE, TBEE, TBBE and TBWE showed excellent ROS (reactive oxygen species) and RNS (reactive nitrogen species) scavenging activities which was investigated using 11 different assays for various free radicals...
December 21, 2016: Cytotechnology
https://www.readbyqxmd.com/read/28000505/uv-b-radiation-increases-anthocyanin-levels-in-cotyledons-and-inhibits-the-growth-of-common-buckwheat-seedlings
#16
Henryk Dębski, Magdalena Szwed, WiesŁaw Wiczkowski, Dorota Szawara-Nowak, Natalia Bączek, Marcin Horbowicz
The impact of short-term UV-B treatment on the content of individual flavonoids and photosynthetic pigments in cotyledons and the growth of common buckwheat (Fagopyrum esculentum Moench) seedlings was investigated. Seeds of four common buckwheat cultivars were germinated in darkness over a period of 4 days and acclimatized for 2 days under a 16/8 h light/dark photoperiod at 24/18 °C day/night, and exposure to 100-120 μmol ∙ m(-2) ∙ s(-1) of photosynthetically active radiation (PAR). Seedlings were divided into three batches, including two batches subjected to different doses of UV-B (5 W ∙ m(-2) and 10 W ∙ m(-2), one hour per day) for 5 days, and a control group exposed to PAR only...
December 2016: Acta Biologica Hungarica
https://www.readbyqxmd.com/read/27995166/quantitative-data-describing-the-impact-of-the-flavonol-rutin-on-in-vivo-blood-glucose-and-fluid-intake-profiles-and-survival-of-human-amylin-transgenic-mice
#17
Jacqueline F Aitken, Kerry M Loomes, Isabel Riba-Garcia, Richard D Unwin, Gordana Prijic, Ashley S Phillips, Anthony R J Phillips, Donghai Wu, Sally D Poppitt, Ke Ding, Perdita E Barran, Andrew W Dowsey, Garth J S Cooper
Here we provide data describing the time-course of blood-glucose and fluid-intake profiles of diabetic hemizygous human-amylin (hA) transgenic mice orally treated with rutin, and matched control mice treated with water. We employed "parametric change-point regression analysis" for investigation of differences in time-course profiles between the control and rutin-treatment groups to extract, for each animal, baseline levels of blood glucose and fluid-intake, the change-point time at which blood glucose (diabetes-onset) and fluid-intake (polydipsia-onset) accelerated away from baseline, and the rate of this acceleration...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/27988826/rutin-nickel-complex-synthesis-characterization-antioxidant-dna-binding-and-dna-cleavage-activities
#18
Aun Raza, Shumaila Bano, Xiuquan Xu, Rong Xian Zhang, Haider Khalid, Furqan Muhammad Iqbal, Changkun Xia, Jian Tang, Zhen Ouyang
The rutin-nickel (II) complex (RN) was synthesized and characterized by elemental analysis, UV-visible spectroscopy, IR, mass spectrometry, (1)H NMR, TG-DSC, SEM, and molar conductivity. The low molar conductivity value investigates the non-electrolyte nature of the complex. The elemental analysis and other physical and spectroscopic methods reveal the 1:2 stoichiometric ratio (metal/ligand) of the complex. An antioxidant study of rutin and its metal complex against DPPH radical showed that the complex has more radical scavenging activity than free rutin...
December 17, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27986088/designing-and-screening-of-universal-drug-from-neem-azadirachta-indica-and-standard-drug-chemicals-against-influenza-virus-nucleoprotein
#19
Aftab Ahmad, Muhammad Rizwan Javed, Abdul Qayyum Rao, Tayyab Husnain
BACKGROUND: Different strains of influenza virus are affecting a large number of people worldwide. Many synthetic antiviral medicines are available for influenza virus in the market. But still there is a need for the development of universal drugs against these strains of influenza virus. METHODS: For this purpose conserved residues within the influenza virus nucleoprotein have been retrieved. The drugs, previously known to have antiviral properties, were screened to identify the best candidate universal drug against Influenza virus strains...
December 16, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27984853/butia-spp-arecaceae-lc-ms-based-metabolomics-for-species-and-geographical-origin-discrimination
#20
Jessica Fernanda Hoffmann, Ivan Ricardo Carvalho, Rosa Lia Barbieri, Cesar Valmor Rombaldi, Fabio Clasen Chaves
The metabolic variability of fruit from Butia spp. (Arecaceae) genotypes from different geographical locations was characterized using untargeted metabolomics by liquid chromatography-mass spectrometry (LC-MS) followed by multivariate data analyses. Principal component analysis (PCA) and partial least-squares discriminant analysis (PLS-DA) from LC-MS data sets showed a clear distinction among Butia catarinensis, Butia odorata, Butia paraguayensis, and Butia yatay. The major metabolites that contributed to species discrimination were primary metabolites including sugars and organic acids and specialized metabolites such as tetrahydroxy-trans-stilbene and rutin...
January 18, 2017: Journal of Agricultural and Food Chemistry
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