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https://www.readbyqxmd.com/read/27921399/antioxidant-and-antidiabetic-properties-of-tartary-buckwheat-rice-flavonoids-after-in-vitro-digestion
#1
Tao Bao, Ye Wang, Yu-Ting Li, Vemana Gowd, Xin-He Niu, Hai-Ying Yang, Li-Shui Chen, Wei Chen, Chong-de Sun
Oxidative stress and diabetes have a tendency to alter protein, lipid, and DNA moieties. One of the strategic methods used to reduce diabetes-associated oxidative stress is to inhibit the carbohydrate-digesting enzymes, thereby decreasing gastrointestinal glucose production. Plant-derived natural antioxidant molecules are considered a therapeutic tool in the treatment of oxidative stress and diabetes. The objective of this study was to identify tartary buckwheat rice flavonoids and evaluate the effect of in vitro digestion on their antioxidant and antidiabetic properties...
2016: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/27916942/evidence-of-bioactive-compounds-from-vernonia-polyanthes-leaves-with-topical-anti-inflammatory-potential
#2
Kamilla C M Rodrigues, Lucas A Chibli, Bruna C S Santos, Vanessa S Temponi, Nícolas C C Pinto, Elita Scio, Glauciemar Del-Vechio-Vieira, Maria S Alves, Orlando V Sousa
Vernonia polyanthes Less. (Asteraceae), popularly known as "assa-peixe", is a plant species used in Brazilian traditional medicine for the treatment of cutaneous damage, cicatrization, inflammation, and rheumatism. Based on these ethnopharmacological findings, the current study evaluated the topical anti-inflammatory effects of the hexane (HEVP) and ethyl acetate (EAEVP) extracts from V. polyanthes leaves in experimental models of skin inflammation. Chemical characterization was carried out by HPLC-UV/DAD analysis...
December 1, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27913892/early-harvest-effects-on-hydrophilic-phenolic-components-of-extra-virgin-olive-oils-cvs-ayval%C3%A4-k-memecik-and-topaka%C3%A5-%C3%A4
#3
Fatma Yıldırım, Adnan Nurhan Yıldırım, Gülcan Özkan, Bekir Şan, Mehmet Polat, Hatice Aşık, Yaşar Karakurt, Sezai Ercişli
The study was conducted to determine the effects of cultivar, harvest period, and their interaction on the hydrophilic phenolic components extra virgin olive oils of the cultivars 'Ayvalık,' 'Memecik,' and 'Topakaşı.' Olives were collected at three different harvesting periods: (1) early harvest period-1 (Beginning of spotting), (2) early harvest period-2 (End of spotting), and (3) optimum harvest period. Oils were extracted using the Abencor system. HPLC (High-performance liquid chromatograph) technique was used to quantify the phenolic compounds including tyrosol (p-HPEA), hydroxytyrosol (3,4-DHPEA), luteolin, rutin, quercetin, catechin, sinapinic acid, p-coumaric acid, cinnamic acid, vanillin, vanillic acid, ferulic acid, and gallic acid...
December 2, 2016: Biochemical Genetics
https://www.readbyqxmd.com/read/27907185/antioxidant-antimicrobial-and-cytotoxic-properties-as-well-as-the-phenolic-content-of-the-extract-from-hancornia-speciosa-gomes
#4
Uilson P Santos, Jaqueline F Campos, Heron Fernandes V Torquato, Edgar Julian Paredes-Gamero, Carlos Alexandre Carollo, Leticia M Estevinho, Kely de Picoli Souza, Edson Lucas Dos Santos
Hancornia speciosa Gomes (Apocynaceae) is a fruit tree, popularly known as mangabeira, and it is widely distributed throughout Brazil. Several parts of the plant are used in folk medicine, and the leaf and bark extracts have anti-inflammatory, antihypertensive, antidiabetic, and antimicrobial properties. In this study, we investigated the chemical composition of the ethanolic extract of Hancornia speciosa leaves (EEHS) and its antioxidant, antimicrobial, and cytotoxic activities as well as the mechanisms involved in cell death...
2016: PloS One
https://www.readbyqxmd.com/read/27897983/effects-of-polysaccharide-elicitors-from-endophytic-fusarium-oxysporum-fat9-on-the-growth-flavonoid-accumulation-and-antioxidant-property-of-fagopyrum-tataricum-sprout-cultures
#5
Lingyun Zhong, Bei Niu, Lin Tang, Fang Chen, Gang Zhao, Jianglin Zhao
The purpose of this study was to evaluate the effects of four different fungal polysaccharides, named water-extracted mycelia polysaccharide (WPS), sodium hydroxide-extracted mycelia polysaccharide (SPS), hydrochloric-extracted mycelia polysaccharide (APS), and exo-polysaccharide (EPS) obtained from the endophytic Fusarium oxysporum Fat9 on the sprout growth, flavonoid accumulation, and antioxidant capacity of tartary buckwheat. Without visible changes in the appearance of the sprouts, the exogenous polysaccharide elicitors strongly stimulated sprout growth and flavonoid production, and the stimulation effect was closely related with the polysaccharide (PS) species and its treatment dosage...
November 25, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27888116/hpv16-induces-a-wasting-syndrome-in-transgenic-mice-amelioration-by-dietary-polyphenols-via-nf-%C3%AE%C2%BAb-inhibition
#6
Rui M Gil da Costa, Sofia Aragão, Magda Moutinho, Antonieta Alvarado, Diogo Carmo, Fátima Casaca, Sandra Silva, Joana Ribeiro, Hugo Sousa, Rita Ferreira, Rita Nogueira-Ferreira, Maria João Pires, Bruno Colaço, Carlos Venâncio, Maria Manuel Oliveira, Margarida M S M Bastos, Carlos Lopes, Paula A Oliveira
Cancer patients often show a wasting syndrome for which there are little therapeutic options. Dietary polyphenols have been proposed for treating this syndrome, but their usefulness in cases associated with human papillomavirus (HPV)-induced cancers is unknown. We characterized HPV16-transgenic mice as a model of cancer cachexia and tested the efficacy of long-term oral supplementation with polyphenols curcumin and rutin. Both compounds were orally administered to six weeks-old HPV16-transgenic mice showing characteristic multi-step skin carcinogenesis, for 24weeks...
November 22, 2016: Life Sciences
https://www.readbyqxmd.com/read/27888010/indole-3-acetic-acid-diol-based-ph-sensitive-biological-macromolecule-for-antibacterial-antifungal-and-antioxidant-applications
#7
Chitra G, Franklin D S, Sudarsan S, Sakthivel M, Guhanathan S
Indole-3-acetic acid (IAA)/diol based pH-sensitive biopolymeric hydrogels with tunable biological properties (cytotoxicity, anti-oxidant and anti-fungal) have been synthesized via condensation polymerization. The present study focused on the synthesis of heterocyclic hydrogel using citric acid (CA), indole-3-acetic acid (IAA) and diethylene glycol (DEG) by condensation polymerization. The hydrogels revealed a pH-sensitive swelling behaviour, with increased swelling in acidic media, then turns to decreased the swelling in the basic media...
November 22, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27865831/rutin-suppresses-human-amylin-hiapp-misfolding-and-oligomer-formation-in-vitro-and-ameliorates-diabetes-and-its-impacts-in-human-amylin-hiapp-transgenic-mice
#8
Jacqueline F Aitken, Kerry M Loomes, Isabel Riba-Garcia, Richard D Unwin, Gordana Prijic, Ashley S Phillips, Anthony R J Phillips, Donghai Wu, Sally D Poppitt, Ke Ding, Perdita E Barran, Andrew W Dowsey, Garth J S Cooper
Pancreatic islet β-cells secrete the hormones insulin and amylin, and defective β-cell function plays a central role in the pathogenesis of type-2 diabetes (T2D). Human amylin (hA, also termed hIAPP) misfolds and forms amyloid aggregates whereas orthologous mouse amylin does neither. Furthermore, hA elicits apoptosis in cultured β-cells and β-cell death in ex-vivo islets. In addition, hA-transgenic mice that selectively express hA in their β-cells, manifest β-cell apoptosis and progressive islet damage that leads to diabetes closely resembling that in patients with T2D...
November 16, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27859484/gram-microorganisms-dna-polymerase-inhibition-antibacterial-and-chemical-properties-of-fruit-and-leaf-extracts-of-sorbus-acuparia-and-sorbus-caucasica-var-yaltirikii
#9
Halbay Turumtay, Ahmet Midilli, Emine Akyuz Turumtay, Adem Demir, Emine Kılıçkaya Selvi, Emine Esra Budak, Havva Er, Fatih Kocaimamoglu, Hüseyin Baykal, Ali Osman Belduz, Vagif Atamov, Cemal Sandallı
Investigation of novel plant-based agents might provide alternative antibiotics and thus fight antibiotic resistance. Here, we measured the ability of fruit and leaf extracts of Sorbus aucuparia (Sauc) and endemic Sorbus caucasica var. yaltirikii (Scau) to inhibit non-replicative (Klenow Fragment-KF and Bacillus Large Fragment-BLF) and replicative (DnaE and PolC) bacterial DNA polymerases along with their antimicrobial, DPPH free radical scavenging activity (RSA), and chemical contents by total phenolic content (TPC) and HPLC-DAD analysis...
November 17, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27855956/selected-secondary-metabolites-in-echium-vulgare-l-populations-from-nonmetalliferous-and-metalliferous-areas
#10
Sławomir Dresler, Ewelina Rutkowska, Wiesław Bednarek, Grzegorz Stanisławski, Tomasz Kubrak, Anna Bogucka-Kocka, Małgorzata Wójcik
The aim of this study was to evaluate the effect of severe environmental conditions prevailing on metalliferous waste heaps and heavy metal-contaminated growth substrates on accumulation of selected secondary metabolites, antioxidant capacity, and heavy metal concentration in two metallicolous (MC, MZ) and one nonmetallicolous (NM) populations of Echium vulgare L. The shoots and the roots of the three studied populations were collected from their natural habitats. Additionally, the plants were cultivated on different growth substrates, i...
November 14, 2016: Phytochemistry
https://www.readbyqxmd.com/read/27855932/industrial-processing-versus-home-processing-of-tomato-sauce-effects-on-phenolics-flavonoids-and-in-vitro-bioaccessibility-of-antioxidants
#11
Merve Tomas, Jules Beekwilder, Robert D Hall, Osman Sagdic, Dilek Boyacioglu, Esra Capanoglu
The effect of industrial and home processing, in vitro gastrointestinal digestion, individual phenolic content, and antioxidant capacity of tomato into tomato sauce were investigated. Industrial processing of tomato fruit into sauce had an overall positive effect on the total antioxidant capacity (∼1.2-fold higher) compared to tomato fruit whereas home processing of tomato fruit into sauce led to a decrease in these values. Untargeted LC-QTOF-MS analysis revealed 31 compounds in tomato that changed upon processing, of which 18 could be putatively identified...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27855599/a-highly-polar-phytocomplex-involving-rutin-is-responsible-for-the-neuromuscular-facilitation-caused-by-casearia-sylvestris-gua%C3%A3-atonga
#12
Yoshida Eh, Tribuiani N, Foramiglio Al, Foramiglio Ca, Tavares Rvs, Bonomini Tj, Bueno Pcp, Cavalheiro Aj, Hyslop S, Puebla P, San Feliciano A, Oshima-Franco Y
BACKGROUND: Of the various biological activities ascribed to extracts from Casearia sylvestris (guaçatonga), its facilitatory activity, i.e., ability to increase skeletal muscle contractile amplitude, has promising therapeutic applications. In this work, we investigated the components responsible for the previously described neurofacilitation caused by C. sylvestris leaves. METHODS: The methanolic fraction of C. sylvestris leaves was initially fractionated by column chromatography and partitioned in a MeOH:H2O gradient...
November 17, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27854256/natural-deep-eutectic-solvents-nades-as-a-tool-for-bioavailability-improvement-pharmacokinetics-of-rutin-dissolved-in-proline-glycine-after-oral-administration-in-rats-possible-application-in-nutraceuticals
#13
Marta Faggian, Stefania Sut, Beatrice Perissutti, Valeria Baldan, Iztok Grabnar, Stefano Dall'Acqua
There is a need for innovation in plant-derived pharmaceuticals, food supplements and nutraceutical products regarding the use of more eco-sustainable solvents for their extraction. Furthermore, the poor oral bioavailability of several phytochemicals with health promoting effects stimulates the research in the field of pharmaceutical formulations. Natural Deep Eutectic Solvents (NADES) are formed by natural compounds, and can be considered as future solvents being especially useful for the preparation of nutraceuticals and food-grade extracts...
November 14, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27847821/djulis-chenopodium-formosanum-koidz-water-extract-and-its-bioactive-components-ameliorate-dermal-damage-in-uvb-irradiated-skin-models
#14
Yong-Han Hong, Ya-Ling Huang, Yao-Cheng Liu, Pi-Jen Tsai
Dermal photoaging is a condition of skin suffering inappropriate ultraviolet (UV) exposure and exerts inflammation, tissue alterations, redness, swelling, and uncomfortable feelings. Djulis (Chenopodium formosanum Koidz.) is a cereal food and its antioxidant and pigment constituents may provide skin protection from photoaging, but it still lacks proved experiments. In this study, protective effects of djulis extract (CFE) on UVB-irradiated skin were explored. The results showed that HaCaT cells with 150 μg/mL CFE treatment had higher survival and less production of interleukin- (IL-) 6, matrix metalloprotease- (MMP-) 1, and reactive oxygen species (ROS) in UVB-irradiated conditions...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27847275/preparation-and-tableting-of-long-term-stable-amorphous-rutin-using-porous-silica
#15
Qionghua Wei, Cornelia M Keck, Rainer H Müller
Amorphous state of drugs increases the oral bioavailability, but typically faces physical stability problems. Amorphous rutin was generated and physically stabilized by encapsulating inside mesopores of porous AEROPERL® 300 Pharma and named as rutin CapsMorph® in this study. AEROPERL® 300 Pharma was loaded with rutin dissolved in DMSO containing Tween 80, and subsequently the solvent evaporated (wetness impregnation method). The loading process was monitored by light microscopy and scanning electron microscopy (SEM)...
November 12, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27843005/zanthoxylum-bungeanum-pericarp-extract-prevents-dextran-sulfate-sodium-induced-experimental-colitis-in-mice-via-the-regulation-of-tlr4-and-tlr4-related-signaling-pathways
#16
Zecai Zhang, Jiuxi Liu, Peng Shen, Yongguo Cao, Xiaojie Lu, Xuejiao Gao, Yunhe Fu, Bo Liu, Naisheng Zhang
Zanthoxylum bungeanum, which belongs to the Zanthoxylum genus of the Rutaceae family, is now wildly distributed in most parts of China and some Southeast Asian countries. The pericarp of Zanthoxylum bungeanum has been known to exhibit antibacterial, anti-inflammatory and other important therapeutic activities. The purpose of this study was to investigate the effects and mechanisms of Zanthoxylum bungeanum pericarp extract (ZBE) on DSS-induced experimental colitis in mice. The results demonstrated that the major flavonoid composition of ZBE includes rutin (32...
November 11, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27836511/deep-sequencing-of-the-transcriptome-reveals-distinct-flavonoid-metabolism-features-of-black-tartary-buckwheat-fagopyrum-tataricum-garetn
#17
REVIEW
Huipeng Yao, Chenglei Li, Haixia Zhao, Jianlan Zhao, Hui Chen, Tongliang Bu, Wang Anhu, Qi Wu
Black tartary buckwheat is recognized as 'black pearl' because of containg more rutin and other flavonoids as compared to yellow tartary buckwheat (traditional tartary buckwheat). Here, we show a genome-wide comparison of their transcriptomes by using an RNA-seq approach to elucidate the different molecular metabolism on the flowers from Black tartary buckwheat (HEIFENG No1) and yellow tartary buckwheat (XIQIAO No2). Over 48.4 million paired-end reads were assembled into 57,800 unigenes, of which about 57.9% (33, 472 unigenes) were annotated by BLAST searches in the NCBI non-redundant protein database...
November 8, 2016: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/27835979/pharmacologically-active-flavonoids-from-the-anticancer-antioxidant-and-antimicrobial-extracts-of-cassia-angustifolia-vahl
#18
Shabina Ishtiaq Ahmed, Muhammad Qasim Hayat, Muhammad Tahir, Qaisar Mansoor, Muhammad Ismail, Kristen Keck, Robert B Bates
BACKGROUND: Cassia angustifolia Vahl. (commonly known as senna makkai or cassia senna), native to Saudi Arabia, Egypt, Yemen and also extensively cultivated in Pakistan, is a medicinal herb used traditionally to cure number of diseases like liver diseases, constipation, typhoid, cholera etc. This study was conducted to evaluate the in-vitro antimicrobial, antioxidant and anticancer assays and phytochemical constituents of aqueous and organic extracts of C. angustifolia leaves. METHODS: The antimicrobial activities of C...
November 11, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27833897/anticancer-antioxidant-potential-and-profiling-of-polyphenolic-compounds-of-wrightia-tinctoria-roxb-r-br-bark
#19
Nishat Fatima, Mohammad Kaleem Ahmad, Jamal Akhtar Ansari, Zulfiqar Ali, Abdul Rahman Khan, Abbas Ali Mahdi
Wrightia tinctoria Roxb. (R.Br.) is an Ayurvedic remedy, ethnomedically used in the treatment of various ailments. The present work was carried out to evaluate the anticancer and antioxidant activity as well as total phenolic and phytochemical contents of W. tinctoria bark methanolic extract (WTBM) by high-performance liquid chromatography (HPLC)-diode array detector. Antiproliferative activity of WTBM was evaluated against MDA-MB-231 and MCF-7 cancer cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, colony formation, and Hoechst staining...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833633/occurrence-and-distribution-of-phytochemicals-in-the-leaves-of-17-in-vitro-cultured-hypericum-spp-adapted-to-outdoor-conditions
#20
Andrea Kucharíková, Souvik Kusari, Selahaddin Sezgin, Michael Spiteller, Eva Čellárová
A plethora of plants belonging to the genus Hypericum have been investigated so far owing to the biological efficacies of pharmacologically important secondary metabolites produced by several Hypericum species. However, there is currently a dearth of information about the localization (accumulation) of these compounds in the plants in situ. In particular, the biosynthetic and ecological consequence of acclimatization of in vitro cultured Hypericum spp. to outdoor conditions is not fully known. Herein, we report an application of matrix-assisted laser desorption/ionization high-resolution mass spectrometry (MALDI-HRMS) to reveal the distribution of major naphthodianthrones hypericin, pseudohypericin, protohypericin, and their proposed precursor emodin as well as emodin anthrone, along with the phloroglucinol derivative hyperforin, the flavonoids quercetin, quercitrin, rutin and hyperoside (and/or isoquercitrin), and chlorogenic acid in Hypericum leaves...
2016: Frontiers in Plant Science
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