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https://www.readbyqxmd.com/read/29345910/qualitative-and-quantitative-analysis-of-ethanolic-extract-and-phenolic-fraction-of-jatropha-aethiopica-euphorbiaceae-leaves-and-their-hypoglycemic-potential
#1
Daylin Gamiotea-Turro, Nathalia Aparecida de Paula Camaforte, Alexander Barbaro Valerino-Diaz, Yarelis Ortiz Nunez, Daniel Rinaldo, Anne Ligia Dokkedal, José Roberto Bosqueiro, Lourdes Campaner Dos Santos
While Jatropha aethiopica, popularly known in Cuba as "mata diabetes", is used in salads and as a dietary supplement, its chemical composition and antidiabetic properties yet remains unclear. In this work, we evaluate the qualitative and quantitative composition of ethanolic extract (EE) and phenolic fraction (PF) of Jatropha aethiopica, leaves and their hypoglycemic and hypolipidemic activity. Chemical fractionation of the ethanolic extract yielded nine compounds, which included protocatechuic acid (1), chlorogenic acid (2), caffeic acid (3), quercetin 3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranolsyl-(1→6)]-β-D-galactopyranoside (4), a new kaempferol 3-O-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranolsyl-(1→6)]-β-D-galactopyranoside (5), kaempferol 3-O-α-L-rhamnopyranosyl-(1→2[α-L-rhamnopyranolsyl-(1→6)]-β-D-glucopyranoside (6), rutin (7), kaempferol 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (8) and quercetin (9)...
January 18, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29342884/effect-of-the-extraction-process-on-the-biological-activity-of-lyophilized-apricot-extracts-recovered-from-apricot-pomace
#2
Dina Cheaib, Nada El Darra, Hiba N Rajha, Iman El-Ghazzawi, Richard G Maroun, Nicolas Louka
The preservation of polyphenols in fruits by lyophilization has gained great interest in the recent decades. The present study aims to assess the impact of the pre-treatment extraction methods heat-assisted extraction (HAE) and infrared (IR) on lyophilized apricot pomace extracts. Then to test the conservation of polyphenols quantities as well as their bioactivities (antiradical and antibacterial) in lyophilized extract. An aqueous extract was obtained through either heat-assisted extraction or infrared pre-treatments then lyophilized to obtain a dried form...
January 14, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29341798/phenolic-constituents-and-inhibitory-effects-of-hibiscus-sabdariffa-l-sorrel-calyx-on-cholinergic-monoaminergic-and-purinergic-enzyme-activities
#3
Ganiyu Oboh, Taiwo M Adewuni, Adedayo O Ademiluyi, Tosin A Olasehinde, Ayokunle O Ademosun
This study revealed the effect of phenolic extract from Hibiscus sabdariffa L. (sorrel) calyx on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidase (MAO), and ecto-5' nucleotidase (E-NTDase) activities as well as pro-oxidant-induced oxidative damage in rat brain in vitro. Sorrel extract inhibited AChE (EC50 = 46.96 µg/mL), BChE (EC50 = 40.38 µg/mL), MAO (EC50 = 43.69 µg/mL), and E-NTDase (EC50 = 40.52 µg/mL) and stimulated Na+/K+-ATPase (EC50 = 22.01 µg/mL) activities. The phenolic extract also reduced Fe2+- (EC50 = 22...
January 17, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29339217/effects-of-rutin-on-the-physicochemical-properties-of-skin-fibroblasts-membrane-disruption-following-uv-radiation
#4
Izabela Dobrzyńska, Agnieszka Gęgotek, Ewelina Gajko, Elżbieta Skrzydlewska, Zbigniew A Figaszewski
Human skin provides the body's first line of defense against physical and environmental assaults. This study sought to determine how rutin affects the membrane electrical properties, sialic acid content, and lipid peroxidation levels of fibroblast membranes after disruption by ultraviolet (UV) radiation. Changes in cell function may affect the basal electrical surface properties of cell membranes, and changes can be detected by electrokinetic measurements. The charge density of the fibroblast membrane surface was measured as a function of pH...
January 12, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29336171/phenolic-composition-antioxidant-and-antinociceptive-activities-of-syringa-vulgaris-l-bark-and-leaf-extracts
#5
Erzsébet Varga, Csenge Barabás, Anita Tóth, Imre Boldizsár, Béla Noszál, Gergő Tóth
Metabolite profile, antioxidant and antinociceptive activities of Syringa vulgaris bark and leaf methanolic extracts were investigated. By means of HPLC-DAD-ESI-TOF and HPLC-DAD-ESI-MS/MS, a total of 33 phenolics were identified, including 15 secoiridoids, 6 phenylpropanoids, 3 flavonoids, 3 lignans and 6 low molecular weight phenols. Validated quantitative analysis show that syringin (2.52%) and rutin (1.13%) are the main phenolic compounds in bark and leaf, respectively. Notable radical scavenging and antinociceptive activities of the bark and leaf extracts were confirmed by in vitro DPPH● and ABTS●+ assays and by in vivo hot-plate method in mice, respectively...
January 16, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29334662/aqueous-extracts-of-two-tropical-ethnobotanicals-tetrapleura-tetraptera-and-quassia-undulata-improved-spatial-and-non-spatial-working-memories-in-scopolamine-induced-amnesic-rats-influence-of-neuronal-cholinergic-and-antioxidant-systems
#6
Veronica O Odubanjo, Emmanuel O Ibukun, Ganiyu Oboh, Stephen A Adefegha
BACKGROUND: Tetrapleura tetraptera (TT) and Quassia undulata (QU) are two predominant tropical ethnobotanicals with various medicinal values but are commonly used in folklore for the treatment of mental illness without justifiable mechanisms of action. AIM OF THE STUDY: To investigate the effects of aqueous extracts from TT fruits and QU leaves on the spatial and non-spatial working memory, antioxidant status and activities of neuronal marker enzymes of scopolamine-induced amnesic rats and thus, understand the possible mechanism of action of these plants...
January 11, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29334238/chemical-constituents-from-the-flowers-of-satsuma-mandarin-and-their-free-radical-scavenging-and-%C3%AE-glucosidase-inhibitory-activities
#7
Anjana Adhikari-Devkota, Sara Mustafa Idris Elbashir, Takashi Watanabe, Hari Prasad Devkota
Flowers of Citrus plants are used as mild sedatives and for the treatment of insomnia in traditional medicines. In Japan, tea made from the flowers of Satsuma mandarin is consumed as healthy drink. Hesperidin (1), hesperetin (2), rutin (3), quercetin (4), nicotiflorin (5), eriocitrin (6), narirutin (7), phenylethyl glucoside (8) and unshuoside A (9) were isolated from the MeOH extract of fresh flowers. Structure elucidation of these compounds was performed on the basis of NMR spectroscopic data. Among them, rutin (3), quercetin (4) and eriocitrin (6) showed potent free radical scavenging activity, whereas hesperetin (2) and quercetin (4) showed potent α-glucosidase inhibitory activity...
January 15, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29333046/development-and-validation-of-high-performance-thin-layer-chromatography-method-for-simultaneous-determination-of-polyphenolic-compounds-in-medicinal-plants
#8
C V Jayachandran Nair, Sayeed Ahamad, Washim Khan, Varisha Anjum, Rajani Mathur
Context: Quantitative standardization of plant-based products is challenging albeit essential to maintain their quality. Aims: This study aims to develop and validate high-performance thin-layer chromatography (HPTLC) method for the simultaneous determination of rutin (Ru), quercetin (Qu), and gallic acid (Ga) from Psidium guajava Linn. (PG) and Aegle marmelos (L.) Correa. (AM) and correlate with antioxidant activity. Materials and Methods: The stock solution (1 mg/mL) of standard Ru, Qu, and Ga in methanol: Water (1:1) was serially diluted and spotted (5 μL) on slica gel 60 F254 thin-layer chromatography plates...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29329862/active-compounds-antioxidant-activity-and-%C3%AE-glucosidase-inhibitory-activity-of-different-varieties-of-chaenomeles-fruits
#9
Jing Miao, Xia Li, Chengcheng Zhao, Xiaoxiao Gao, Ying Wang, Wenyuan Gao
Chaenomeles is an important source for food industry in China, and its planting area is expanding year by year. This study was conducted to evaluate different varieties of Chaenomeles by comparing the chemical compositions, antioxidant activity and α-glucosidase inhibitory activity of peels and fleshes from twelve varieties of Chaenomeles. In the results, peels of Chaenomeles contain more phenolics, flavonoids and triterpenes, and show better antioxidant activity and α-glucosidase inhibitory activity than their fleshes...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329851/chemical-characterization-of-myrciaria-floribunda-h-west-ex-willd-fruit
#10
Luciana Mouta de Oliveira, Alexandre Porte, Ronoel Luiz de Oliveira Godoy, Marcelo da Costa Souza, Sidney Pacheco, Manuela Cristina Pessanha de Araujo Santiago, Ana Cristina Miranda Senna Gouvêa, Luzimar da Silva de Mattos do Nascimento, Renata Galhardo Borguini
M. floribunda fruit was studied to characterize its chemical composition. The chemical composition, bioactive compounds, antioxidant activity and volatiles of the fruit were determined. The chemical composition was determined according to AOAC and AOCS, the bioactive compounds by HPLC, the volatiles by GCMS and the antioxidant activity by ABTS+ and DPPH methods. The chemical composition of the freeze-dried fruit was 1.89 g·100 g-1, 2.43 g·100 g-1, 4.78 g·100 g-1 and 90.89 g·100 g-1 of ashes, lipids, proteins and total carbohydrates on a dry base, respectively...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329242/absorption-and-metabolism-of-phenolics-from-digests-of-polyphenol-rich-potato-extracts-using-the-caco-2-hepg2-co-culture-system
#11
Shima Sadeghi Ekbatan, Michele M Iskandar, Lekha Sleno, Kebba Sabally, Joelle Khairallah, Satya Prakash, Stan Kubow
The bioactivity of dietary polyphenols depends upon gastrointestinal and hepatic metabolism of secondary microbial phenolic metabolites generated via colonic microbiota-mediated biotransformation. A polyphenol-rich potato extract (PRPE) containing chlorogenic, caffeic, and ferulic acids and rutin was digested in a dynamic multi-reactor gastrointestinal simulator of the human intestinal microbial ecosystem (GI model). Simulated digestion showed extensive degradation of the parent compounds and the generation of microbial phenolic metabolites...
January 12, 2018: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29327283/persea-americana-mill-crude-extract-exhibits-antinociceptive-effect-on-uvb-radiation-induced-skin-injury-in-mice
#12
Viviane C K N Deuschle, Indiara Brusco, Mariana Piana, Henrique Faccin, Leandro Machado de Carvalho, Sara Marchesan Oliveira, Carine Viana
Persea americana, popularly known as avocado, has been empirically used as analgesic and anti-inflammatory including in the skin disorder treatment. Species of the genus Persea also show a photoprotective effect against UVB radiation. We investigated the antinociceptive and anti-inflammatory effects from a topical formulation containing the P. americana leaf extract in a UVB irradiation-induced burn model in mice and performed a gel-formulation stability study. The antinociceptive and anti-inflammatory effect was evaluated through mechanical allodynia, paw oedema, and inflammatory cell infiltration...
January 11, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29318289/recovery-of-rutin-from-labisia-pumila-extract-using-solid-phase-extraction
#13
Lee Suan Chua, Nur Nabihah Ruzlan, Mohamad Roji Sarmidi
Reflux extraction was used to prepare crude extract from the leaves of Labisia pumila var. Alata using 60% methanol. The crude extract was subsequently fractionated by C18 solid phase extraction to recover high yield of rutin using 20-100% methanol. The volume of eluent to recover rutin was found to decrease with the increase of methanol concentration. The recovery of rutin was increased from 20 to 80% methanol system, but slightly decreased in the 100% methanol system. Approximately, 70% of rutin could be recovered using the 80% methanol system...
December 2017: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/29316281/hplc-ms-ms-determination-of-flavonoids-in-gleditsiae-spina-for-its-quality-assessment
#14
Jing Li, Kun Jiang, Li-Jun Wang, Guo Yin, Jue Wang, Yang Wang, Yi-Bao Jin, Qing Li, Tie-Jie Wang
Gleditsiae Spina, the thorn of Gleditsia sinensis Lam., has been used as an anti-inflammatory, anti-tumor, and anti-bacterial traditional medicine for hundreds of years in China. This study used high-performance liquid chromatography and tandem mass spectrometry combined with chemometric methods to allow the fast and accurate identification and quantification of the flavonoids compounds in Gleditsiae Spina, and created reliable criteria for accurate identification of Gleditsiae Spina and its adulterants. This research provides good evidence for the classification and quality evaluation of Gleditsiae Spina...
January 5, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29315975/rutin-and-meloxicam-attenuate-paw-inflammation-in-mice-affecting-sorbitol-dehydrogenase-activity
#15
Ebtehal Mohammad F, Wedad A Hasan, Eman G Mohamed
Rutin, naturally occurring flavonoid, has reported to cover interesting multiple pharmacological properties. This study evaluated rutin or/and meloxicam effects in paw inflammation induced by formalin in mice. Mice were divided into four groups: I-Formalin group, II-Rutin 60 mg/kg (p.o.), III-Meloxicam 10 mg/kg (p.o.), plus IV-Combined rutin and meloxicam. Therapies were administered once a day for 7 days. The curative effects were assessed on inflammatory, oxidative stress, and apoptosis. Both rutin and/or meloxicam induced marked improvement in paw licking time on the 1st day and by combined treatment only on the 3rd day as well reduction in paw edema% on the 3rd day...
January 5, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29301523/genoprotective-antioxidant-antifungal-and-anti-inflammatory-evaluation-of-hydroalcoholic-extract-of-wild-growing-juniperus-communis-l-cupressaceae-native-to-romanian-southern-sub-carpathian-hills
#16
Irina Fierascu, Camelia Ungureanu, Sorin Marius Avramescu, Carmen Cimpeanu, Mihaela Ioana Georgescu, Radu Claudiu Fierascu, Alina Ortan, Anca Nicoleta Sutan, Valentina Anuta, Anca Zanfirescu, Cristina Elena Dinu-Pirvu, Bruno Stefan Velescu
BACKGROUND: Juniperus communis L. represents a multi-purpose crop used in the pharmaceutical, food, and cosmetic industry. Several studies present the possible medicinal properties of different Juniperus taxa native to specific geographical area. The present study aims to evaluate the genoprotective, antioxidant, antifungal and anti-inflammatory potential of hydroalcoholic extract of wild-growing Juniperus communis L. (Cupressaceae) native to Romanian southern sub-Carpathian hills. METHODS: The prepared hydroethanolic extract of Juniperus communis L...
January 4, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29300762/drug-repurposing-in-vitro-anti-glycation-properties-of-18-common-drugs
#17
Saima Rasheed, Sara S Sánchez, Sammer Yousuf, Stella M Honoré, M Iqbal Choudhary
Drug repositioning or repurposing, i.e. identifying new indications for existing drugs, has gained increasing attention in the recent years. This approach enables the scientists to discover "new targets" for known drugs in a cost and time efficient manner. Glycation, the non-enzymatic reaction of sugars with proteins or nucleic acids to form early glycation (Amadori or fructosamine) products, is a key molecular basis of diabetic complications. Inhibiting the process of non-enzymatic protein glycation is one of the key strategies to prevent glycation-mediated diabetic complications...
2018: PloS One
https://www.readbyqxmd.com/read/29300477/isolation-of-flavonoids-and-flavonoid-glycosides-from-myrsine-africana-and-their-inhibitory-activities-against-mushroom-tyrosinase
#18
Navneet Kishore, Danielle Twilley, Analike Blom van Staden, Praveen Verma, Bikram Singh, Giorgia Cardinali, Daniela Kovacs, Mauro Picardo, Vivek Kumar, Namrita Lall
Bioassay-guided fractionation of the methanol extract of the shoots of Myrsine africana led to the isolation of the new compound myricetin 3-O-(2″,4″-di-O-acetyl)-α-l-rhamnopyranoside (9) and 11 known compounds. The known compounds quercetin 3-O-(3″,4″-di-O-acetyl)-α-l-rhamnopyranoside (8), rutin (10), quercetin 3-O-α-l-rhamnopyranoside (11), and myricetin 3-O-α-l-rhamnopyranoside (12) are reported for the first time from the methanol extract of the shoots of M. africana. Compounds 10 and 12 showed significant inhibition of tyrosinase with 50% inhibition (IC50 values) of the enzyme at 0...
January 4, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29291577/sensitive-determination-of-rutin-by-spectrofluorimetry-using-carbon-dots-synthesized-from-a-non-essential-amino-acid
#19
B Sinduja, S Abraham John
The present study describes the synthesis of carbon dots (CDs) using a non-essential amino acid, asparagine as a precursor. The HR-TEM image shows that the size of the prepared CDs was 2.9±0.2nm with a spherical morphology. The UV-visible spectrum of CDs exhibits a major band at 307nm along with a shoulder band around 207nm corresponding to n-π* and π-π* transitions, respectively. Further, the CDs show emission maximum at 441nm when excited at 348nm. The synthesized CDs were then exploited for the determination of rutin by spectrofluorimetry based on the decrease in emission intensity at 441nm...
December 27, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29287791/chemical-characterization-antioxidant-genotoxic-and-in-vitro-cytotoxic-activity-assessment-of-juniperus-communis-var-saxatilis
#20
Bojana Vasilijević, Jelena Knežević-Vukčević, Dragana Mitić-Ćulafić, Dejan Orčić, Marina Francišković, Tatjana Srdic-Rajic, Marina Jovanović, Biljana Nikolić
Chemical composition and antioxidative, genotoxic and cytotoxic potential of essential oil (EO) and post-distillation waste (PDW) of Serbian Juniperus communis L. var. saxatilis Pall. was studied in human lung carcinoma (A549) and normal lung fibroblast (MRC-5) cells. GC-MS analysis identified 93.95% of total EO content and determined α-pinen as a dominant component (23.61%). LC-MS/MS analysis of PDW pointed at rutin (12.2 mg g-1) and quinic acid (11.1 mg g-1) as the most abundant. Antioxidativity of PDW was strong in DPPH (IC50 was 5...
December 26, 2017: Food and Chemical Toxicology
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