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https://www.readbyqxmd.com/read/28449398/feeding-induced-phenol-production-in-capsicum-annuum-l-influences-spodoptera-litura-f-larval-growth-and-physiology
#1
Vijaya Movva, Usha Rani Pathipati
We studied the role of induced plant phenols as a defense response to insect herbivory. Phenolic compounds were induced in Capsicum annuum L., the source of many culinary peppers, after feeding by different stages of the insect pest, Spodoptera litura F. The phenols were identified and quantified using high performance liquid chromatography (HPLC) and effects produced by these phenols on larval development were studied. Vanillic acid was identified in plants challenged by second, fourth, and fifth instar larvae, but not in plants challenged by third instar nor unchallenged plants...
May 2017: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/28446228/antigenotoxic-properties-of-paliurus-spina-christi-mill-fruits-and-their-active-compounds
#2
Murat Zor, Sevtap Aydin, Nadide Deniz Güner, Nurşen Başaran, Arif Ahmet Başaran
BACKGROUND: Paliurus spina-christi Mill. (PS) fruits are widely used for different medical purposes in Turkey. Like in many medicinal herbs the studies concerning their activity, the activities of PS are also not well clarified. The aim of this study is to evaluate the antigenotoxicity of the compounds isolated and identified from the extracts of PS fruits. METHODS: The active compounds were separated, isolated, and determined by chromatographic methods and their structural elucidation was performed by Nuclear Magnetic Resonance (NMR) methods...
April 26, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28436633/-lc-ms-guided-approach-to-discovering-nephroprotective-substances-from-huangkui-capsule
#3
Tingting Ma, Yi Wang, Xiaoqian Chen, Xiaoping Zhao
Objective: To discover the nephroprotective substances from Huangkui capsule. Methods: The components of Huangkui capsule were isolated by preparative liquid chromatography, and the active components were screened by LC/MS and identified. The adriamycine-injured HK-2 cells were treated with various active components with different concentrations, and the malonaldehyde (MDA) content, adenosine triphosphate (ATP) level and mitochondrial oxygen consumption rate were measured to verify the protective activity of the compounds...
January 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28431473/structures-and-bioactivities-of-seven-flavonoids-from-osmanthus-fragrans-jinqiu-essential-oil-extraction-residues
#4
Jiang-Lian Zhou, Xian-Ying Fang, Jing-Qiu Wang, Lin-Guo Zhao, Yi Li, Feng Tang, Yong-De Yue
Osmanthus fragrans are well-known for their fragrance, but it is wasteful if to discard O. fragrans flower after extracting their essential oils. In this paper, we found that O. fragrans flower residues were rich in flavonoids. Six flavonoids and one phenylethanoid glycoside were isolated from the ethanol extract of O. fragrans flower residues, identified as quercetin (1), rutin (2), verbascoside (3), genistin (4), kaempferol (5), isorhamnetin (6) and naringin (7). In bioactivity study, kaempferol (IC50 = 1...
April 21, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28427640/comparative-evaluation-of-maceration-and-ultrasonic-assisted-extraction-of-phenolic-compounds-from-fresh-olives
#5
Junlin Deng, Zhou Xu, Chunrong Xiang, Jing Liu, Lijun Zhou, Tian Li, Zeshen Yang, Chunbang Ding
Ultrasonic-assisted extraction (UAE) and maceration extraction (ME) were optimized using response surface methodology (RSM) for total phenolic compounds (TPC) from fresh olives. The main phenolic compounds and antioxidant activity of TPC were also investigated. The optimized result for UAE was 22mL/g of liquid-solid ratio, 47°C of extraction temperature and 30min of extraction time, 7.01mg/g of yielding, and for ME was 24mL/g of liquid-solid ratio, 50°C of extraction temperature and 4.7h of extraction time, 5...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28420354/therapeutic-potentials-of-crataegus-azarolus-var-eu-azarolus-maire-leaves-and-its-isolated-compounds
#6
Eman Abu-Gharbieh, Naglaa Gamil Shehab
BACKGROUND: Hyperglycemia is a complicated condition accompanied with high incidence of infection and dyslipidemia. This study aimed to explore the phyto-constituents of Crataegus azarolus var. eu- azarolus Maire leaves, and to evaluate the therapeutic potentials particularly antimicrobial, antihyperglycemic and antihyperlipidemic of the extract and the isolated compound (3β-O-acetyl ursolic acid). METHODS: Total phenolics and flavonoidal contents were measured by RP-HPLC analysis...
April 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28420145/evaluation-of-polyphenolic-content-antioxidant-and-diuretic-activities-of-six-fumaria-species
#7
Ramona Păltinean, Andrei Mocan, Laurian Vlase, Ana-Maria Gheldiu, Gianina Crișan, Irina Ielciu, Oliviu Voștinaru, Ovidiu Crișan
Romanian traditional medicine describes the use of aerial parts of Fumaria species to treat hepatobiliary diseases as well as diuretic agents. The present study aims to investigate the chemical composition, antioxidant properties, and diuretic effects of several Fumaria species. LC/MS analysis revealed that Fumaria species contain phenolic acids and high amounts of flavonoids with rutin and isoquercitrin as main compounds. Concerning antioxidant capacity, the most significant results were obtained for F. capreolata and F...
April 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28419969/neurotoxic-effects-of-silver-nanoparticles-and-the-protective-role-of-rutin
#8
Mona M Ahmed, Mohamed M A Hussein
The toxicological studies on silver nanoparticles (Ag-NPs) have become a hot topic over the past few decades due to their unique properties on the nanoscale and widespread in many commercial products that launched into the market recently. This study was undertaken to shed light on Ag-NPs toxicity on neurotransmitters with special emphasis on the impact of concurrent administration of rutin with Ag-NPs in the experimental rats. The oral administration of Ag-NPs in rats induced brain oxidative stress, significant alterations in neurotransmitters and amino acids...
April 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28416860/characterization-of-phenolic-profile-and-antioxidant-capacity-of-different-fruit-part-from-lemon-citrus-limon-burm-cultivars
#9
Wanpeng Xi, Juanfang Lu, Junping Qun, Bining Jiao
Phenolic composition and antioxidant capacity of different fruit part including peel, pulp, juice, whole fruit and seed from five lemon cultivars (Feiminailao, Cuningmeng Limeng, Pangdelusaningmeng, Beijingningmeng) were investigated. Caffeic acid (9.31-741.4 μg/g FW) and chlorogenic acid (2.7-527.5 μg/g FW) were the dominant phenolic acid in fruit tested, Pangdelusaningmeng (PD) and Limeng peels with the highest contents, respectively. Hesperidin was the predominant flavanone (10.27-3315 μg/g FW), Cuningmeng (CN) peels with the highest level...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28412651/time-dependent-effect-of-rutin-on-skin-fibroblasts-membrane-disruption-following-uv-radiation
#10
Agnieszka Gęgotek, Katarzyna Bielawska, Michał Biernacki, Izabela Dobrzyńska, Elżbieta Skrzydlewska
Chronic exposure of the skin to solar UV radiation induces a number of biological alterations, including a redox imbalance; therefore, there is an urgent need for skin cells protective compounds. The aim of this study was to determine the effects of natural, previously extensively examined, polyphenol with antioxidant properties - rutin, on UV-induced skin fibroblasts membrane disruption. Accordingly, fibroblasts exposed to UVA and UVB irradiation were incubated with rutin (12h before and/or up to 24h after irradiation), and the structural and metabolic changes were examined...
April 9, 2017: Redox Biology
https://www.readbyqxmd.com/read/28411511/elevated-co2-and-salinity-are-responsible-for-phenolics-enrichment-in-two-differently-pigmented-lettuces
#11
Cristina Sgherri, Usue Pérez-López, Francesco Micaelli, Jon Miranda-Apodaca, Amaia Mena-Petite, Alberto Muñoz-Rueda, Mike Frank Quartacci
Both salt stress and high CO2 level, besides influencing secondary metabolism, can affect oxidative status of plants mainly acting in an opposite way with salinity provoking oxidative stress and elevated CO2 alleviating it. The aim of the present work was to study the changes in the composition of phenolic acids and flavonoids as well as in the antioxidant activity in two differently pigmented lettuce cvs (green or red leaf) when submitted to salinity (200 mM NaCl) or elevated CO2 (700 ppm) or to their combination in order to evaluate how a future global change can affect lettuce quality...
April 7, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28408800/rutin-protects-against-neuronal-damage-in-vitro-and-ameliorates-doxorubicin-induced-memory-deficits-in-vivo-in-wistar-rats
#12
Grandhi Venkata Ramalingayya, Sri Pragnya Cheruku, Pawan G Nayak, Anoop Kishore, Rekha Shenoy, Chamallamudi Mallikarjuna Rao, Nandakumar Krishnadas
Doxorubicin (DOX) is the most widely used broad-spectrum anticancer agent, either alone or in combination, for most cancers including breast cancer. Long-term use of chemotherapeutic agents to treat breast cancer patients results in cognitive complications with a negative impact on survivors' quality of life. The study objective was to evaluate rutin (RUT) for its neuroprotective effect against DOX in human neuroblastoma (IMR32) cells in vitro and study its potential to ameliorate DOX-induced cognitive dysfunction in Wistar rats...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28407908/stability-of-goji-bioactives-during-extrusion-cooking-process
#13
Agnieszka Kosińska-Cagnazzo, Dimitri Bocquel, Isabelle Marmillod, Wilfried Andlauer
Due to the increasing popularity of goji berries, efforts are made to enlarge the offer of goji containing foods. In this study, rice flour based extrudates enriched with goji berries were investigated. The extrusion was performed using a twin screw extruder with constant feed moisture and screw speed. Raw mixtures as well as extruded products obtained were analysed in order to determine antioxidant activity and contents of rutin, zeaxanthin dipalmitate and 2-O-β-d-glucopyranosyl-l-ascorbic acid. The antioxidant activity of goji extrudates was boosted up to 20times compared to the extrudates without any addition...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28400288/ocimum-gratissimum-l-leaf-flavonoid-rich-fraction-suppress-lps-induced-inflammatory-response-in-raw-264-7-macrophages-and-peritonitis-in-mice
#14
Abayomi Mayowa Ajayi, Domingos Tabajara de Oliveira Martins, Sikiru Olaitan Balogun, Ruberlei Godinho de Oliveira, Sérgio Donizeti Ascêncio, Olusegun George Ademowo
ETHNOPHARMACOLOGICAL RELEVANCE: Ocimum gratissimum L. is a herbaceous plant that has been reported in several ethnopharmacological surveys as a plant readily accessible to the communities and widely used for the treatment of inflammatory diseases. The main goal of this study was to investigate the in vitro and in vivo anti-inflammatory activity and mechanism of action of the ethylacetate fraction of O. gratissimum leaf (EAFOg) and to chemically characterize this fraction. MATERIALS AND METHODS: EAFOg was obtained from a sequential methanol extract...
April 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28399868/4-5-4-trihydroxychalcone-8-8-ethene-1-2-diyl-dinaphtalene-1-4-5-triol-and-rutin-from-gynura-segetum-inhibit-phagocytosis-lymphocyte-proliferation-cytokine-release-and-nitric-oxide-production-from-phagocytic-cells
#15
Yuandani, Ibrahim Jantan, Khairana Husain
BACKGROUND: Gynura segetum is used traditionally to treat various ailments related to the immune system, which include cancer, inflammation, rheumatism, diabetes, hypertension, and viral infections but little studies have been carried out to validate their ethnopharmacological aspects. In this study the immunosuppressive effects of G. segetum and its constituents were investigated. METHODS: Isolation of compounds from G. segetum leaves was conducted using vacuum liquid chromatography (VLC) and column chromatography (CC)...
April 11, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28392963/treatment-with-rutin-a-therapeutic-strategy-for-neutrophil-mediated-inflammatory-and-autoimmune-diseases-anti-inflammatory-effects-of-rutin-on-neutrophils
#16
Bahareh Abd Nikfarjam, Mohtaram Adineh, Farid Hajiali, Marjan Nassiri-Asl
OBJECTIVES: Neutrophils represent the front line of human defense against infections. Immediately after stimulation, neutrophilic enzymes are activated and produce toxic mediators such as pro-inflammatory cytokines, nitric oxide (NO) and myeloperoxidase (MPO). These mediators can be toxic not only to infectious agents but also to host tissues. Because flavonoids exhibit antioxidant and anti-inflammatory effects, they are subjects of interest for pharmacological modulation of inflammation...
March 2017: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/28391725/identification-and-in-vitro-antioxidant-activities-of-phenolic-compounds-isolated-from-cynoglossum-cheirifolium-l
#17
Bensaid Ilhem, Atik Bekkara Fawzia, El Haci Imad Abdelhamid, Belarbi Karima, Beddou Fawzia, Bekhechi Chahrazed
In an extensive search for bioactive compounds from plant sources, the quantitative and qualitative characterisation of the compounds present in Cynoglossum cheirifolium extracts was studied. Total phenolic and flavonoid contents were determined by spectrophotometric techniques. In vitro antioxidant and radical scavenging profiling was determined through DPPH(•) scavenging activity and Ferric reducing antioxidant power (FRAP). Our study showed that leaves produce more phenolic compounds, followed by flowering aerial part...
April 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28391717/modulation-of-antibiotic-activity-by-the-hydroalcoholic-extract-from-leaves-of-caryocar-coriaceum-wittm
#18
Luís J de Lacerda Neto, A G B Ramos, M R Kerntopf, H D M Coutinho, L J Quintans-Junior, J R G S Almeida, J Ribeiro-Filho, I R A Menezes
The aim of this study was to identify the presence of tannins, phenols and flavonoids on the hydroalcoholic extract of Caryocar coriaceum leaves (HECCL) and to determine the antioxidant and antibacterial activity of this extract. The extract was tested alone (1024-1 μg/mL) or associated (MIC/8) with several antibiotics in order to identify any antibacterial activity against multiresistant bacterial strains (Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa). The existence of tannins, total phenols (901...
April 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28390858/combining-in%C3%A2-vitro-in%C3%A2-vivo-and-in-silico-approaches-to-evaluate-nutraceutical-potentials-and-chemical-fingerprints-of-moltkia-aurea-and-moltkia-coerulea
#19
Gokhan Zengin, Ramazan Ceylan, Jelena Katanić, Adriano Mollica, Abdurrahman Aktumsek, Tatjana Boroja, Sanja Matić, Vladimir Mihailović, Snežana Stanić, Zaahira Aumeeruddy-Elalfi, Mustafa Abdullah Yilmaz, Mohamad Fawzi Mahomoodally
Methanolic extracts of Moltkia aurea Boiss. (MA) and Moltkia coerulea (Willd.) Lehm. (MC) were investigated for their antioxidant capacity and enzymatic inhibitory potential against acetylcholinesterase, butyrylcholinesterase, α-amylase, α-glucosidase, and tyrosinase in vitro. MA and MC were also explored for their antimicrobial effect, as well as for their possible genotoxic/antigenotoxic potential on Drosophila melanogaster in vivo. The total bioactive components (phenolic (TPC) and flavonoid contents (TFC)) were determined and liquid chromatography-tandem mass spectrometry (LC-MS/MS) metabolite profiling of MA and MC appraised...
April 5, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28389882/hormetic-efficacy-of-rutin-to-promote-longevity-in-drosophila-melanogaster
#20
Debarati Chattopadhyay, Atith Chitnis, Aishwarya Talekar, Prajakta Mulay, Manyata Makkar, Joel James, Kavitha Thirumurugan
Hormetins are compounds that mediate hormesis by being beneficial at low doses but detrimental at high doses. Recent studies have highlighted that many compounds that extended lifespan in model organisms did so by mediating hormesis. Rutin is a glycosylate conjugate of quercetin and rutinose and is abundant in citrus fruits and buckwheat seeds. Rutin possess ROS scavenging, anti-cancer, cardio-protective, skin-regenerative and neuro-protective properties. Drosophila melanogaster is an attractive model organism for longevity studies owing to its homology of organ and cellular-pathways with mammals...
April 7, 2017: Biogerontology
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