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https://www.readbyqxmd.com/read/28930257/physicochemical-properties-antioxidant-and-cytotoxic-activities-of-crude-extracts-and-fractions-from-phyllanthus-amarus
#1
Van Tang Nguyen, Jennette A Sakoff, Christopher J Scarlett
Background:Phyllanthus amarus (P. amarus) has been used as a medicinal plant for the prevention and treatment of chronic ailments such as diabetes, hepatitis, and cancer. Methods: The physicochemical properties, antioxidant and cytotoxic activities of crude extracts and fractions from P. amarus were determined using spectrophotometric method. Results: The P. amarus methanol (PAM) extract had lower levels of residual moisture (7.40%) and water activity (0.24) and higher contents of saponins, phenolics, flavonoids, and proanthocyanidins (1657...
June 18, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28929656/-analysis-and-utilization-value-discussion-of-multiple-chemical-composition-in-different-tissues-of-abelmoschus-manihot
#2
Jie Liu, Sheng Guo, Jin-Ao Duan, Hui Yan, Da-Wei Qian, Hai-Tao Tang, Ren-Mao Tang
This research is to analyze the resourceful chemical composition in different tissues (root, stem, leaf and flower) of Abelmoschus manihot and evaluate their utilizing value. The flavonoids, soluble polysaccharides, cellulose, nucleosides and amino acids in the different tissues of A. manihot were determined by HPLC coupled with UV-Vis spectrophotpmetry, and UPLC-TQ/MS. The flowers are rich in the resourceful chemical compositions of flavonoids which mainly consist of hyperoside, isoquercitrin, cotton-8-O-glucuronide, myricetin, quercetin-3'-O-glucoside, rutin and quercetin...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28929569/evaluation-of-chemical-chaperones-based-on-the-monitoring-of-bip-promoter-activity-and-visualization-of-extracellular-vesicles-by-real-time-bioluminescence-imaging
#3
Tomohisa Horibe, Nanako Okushima, Aya Torisawa, Ryutaro Akiyoshi, Yoko Hatta-Ohashi, Hirobumi Suzuki, Koji Kawakami
It is known that endoplasmic reticulum (ER) stress in cells and extracellular vesicles (EVs) plays a significant role in cancer cells, therefore the evaluation of compounds that can regulate ER stress and EV secretion would be a suitable system for further screening and development of new drugs. In this study, we evaluated chemical chaperones derived from natural products based on monitoring Bip/GRP78 promoter activity during cancer cell growth, at the level of the single cell, by a bioluminescence microscopy system that had several advantages compared with fluorescence imaging...
September 20, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28929052/simultaneous-determination-of-rutin-isoquercetin-and-quercetin-flavonoids-in-nelumbo-nucifera-by-high-performance-liquid-chromatography-method
#4
P Naveen, H B Lingaraju, Anitha, K Shyam Prasad
OBJECTIVE: The present study was investigated to provide a documentary evidence for the determination of rutin, isoquercetin, and quercetin flavonoids from the flora of Nelumbo nucifera by reversed-phase high-performance liquid chromatography (RP-HPLC). MATERIALS AND METHODS: RP-HPLC analysis was performed by gradient elution with a low-pressure gradient using 0.5% acetic acid: acetonitrile as a mobile phase with a flow rate of 1.0 ml/min. The separation was done at 26°C using a Kinetex XB-C18 column as stationary phase and the detection wavelength at 356 nm...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28928906/comparison-of-anti-inflammatory-effects-of-flavonoid-rich-common-and-tartary-buckwheat-sprout-extracts-in-lipopolysaccharide-stimulated-raw-264-7-and-peritoneal-macrophages
#5
Tae Gyu Nam, Tae-Gyu Lim, Bong Han Lee, Sol Lim, Hee Kang, Seok Hyun Eom, Miyoung Yoo, Hae Won Jang, Dae-Ok Kim
Buckwheat sprouts have been widely consumed all around world due to their great abundance of bioactive compounds. In this study, the anti-inflammatory effects of flavonoid-rich common buckwheat sprout (CBS) and tartary buckwheat sprout (TBS) extracts were evaluated in lipopolysaccharide- (LPS-) stimulated RAW 264.7 murine macrophages and primary peritoneal macrophages from male BALB/c mice. Based on the reversed-phase HPLC analysis, the major flavonoids in CBS were determined to be C-glycosylflavones (orientin, isoorientin, vitexin, and isovitexin), quercetin-3-O-robinobioside, and rutin, whereas TBS contained only high amounts of rutin...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28917811/electrochemical-characterization-of-in-situ-functionalized-gold-organosulfur-self-assembled-monolayer-with-conducting-polymer-and-carbon-nanotubes-for-determination-of-rutin
#6
Majid Arvand, Mona Farahpour, Masoomeh Sayyar Ardaki
In this study, attempts were made to present a sensitive strategy for determining rutin. To reach the goal of the study, a poly(sulfosalicylic acid) film was electropolymerized on a gold electrode, which was modified by 2-mercaptobenzothiazole self-assembled monolayer and multi-walled carbon nanotubes (PSSA/CNTs/MBT/Au). The proposed sensor was characterized by different techniques including field emission scanning electron microscopy, energy dispersive X-ray spectroscopy and Fourier transform infrared spectroscopy...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28911741/growth-hydrolases-and-ultrastructure-of-fusarium-oxysporum-as-affected-by-phenolic-rich-extracts-from-several-xerophytic-plants
#7
Mahmoud S M Mohamed, Ahmed M Saleh, Ibrahim B Abdel-Farid, Sabry A El-Naggar
Fusarium oxysporum, the causal agent of rot and wilt diseases, is one of the most detrimental phytopathogens for the productivity of many economic crops. The present study was conducted to evaluate the potentiality of some xerophytic plants as eco-friendly approach for management of F. oxysporum. Phenolic rich extracts from five plants namely: Horwoodia dicksoniae, Citrullus colocynthis, Gypsophila capillaris, Pulicaria incisa and Rhanterium epapposum were examined in vitro. The different extracts showed high variability in their phenolic and flavonoid contents as well as total antioxidant capacity...
September 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28906145/protective-effect-of-rutin-against-brain-injury-induced-by-acrylamide-or-gamma-radiation-role-of-pi3k-akt-gsk-3%C3%AE-nrf-2-signalling-pathway
#8
Noura M Thabet, Enas M Moustafa
This study was designed to evaluate the effect of rutin on PI3K/AKT-signalling in case of acrylamide or γ-radiation-induced neurotoxicity. To induce brain damage, animals were received acrylamide (25 mg/kg b.wt./orally/day) or 5 Gy of γ-radiation exposure accompanied with an administration of rutin (200 mg/kg b.wt./orally/day). Our data revealed that, compared to acrylamide or γ-radiation, rutin activated PI3K/AKT/GSK-3β/NRF-2-pathway through increased protein levels of p-PI3K, p-AKT and p-GSK-3β and up-regulated the expression of NRF-2...
September 14, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28892755/studies-on-the-competitive-binding-of-cleviprex-and-flavonoids-to-plasma-protein-by-multi-spectroscopic-methods-a-prediction-of-food-drug-interaction
#9
Xin Wang, Xue-Yuan Guo, Liang Xu, Bin Liu, Ling-Ling Zhou, Xiao-Fang Wang, Dan Wang, Ting Sun
Cleviprex is a short-acting dihydropyridine calcium channel antagonist used as an antihypertensive drug. In this work, the binding characterization of cleviprex to human serum albumin (HSA) and the competitive binding to HSA between cleviprex and two flavonoids, baicalin and rutin, were studied using multi-spectroscopic techniques and molecular docking method. The fluorescence quenching of HSA by cleviprex was initiated by the formation of HSA-cleviprex complex, which was confirmed by UV-vis spectra measurements...
September 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28888794/rutin-exploitation-of-the-flavonol-for-health-and-homeostasis
#10
EDITORIAL
Abdur Rauf, Muhammad Imran, Seema Patel, Rizwana Muzaffar, Saud S Bawazeer
No abstract text is available yet for this article.
September 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28888145/nmr-based-identification-of-the-major-bioactive-molecules-from-an-italian-cultivar-of-lycium-barbarum
#11
Annalisa Lopatriello, Rosario Previtera, Simona Pace, Markus Werner, Luigi Rubino, Oliver Werz, Orazio Taglialatela-Scafati, Martino Forino
Lycium barbarum (Solanaceae), long known to the traditional Chinese medicine because of its many health-promoting effects, has of late spread widely across the Western hemisphere, mainly on account of the nutritional richness in vitamins, minerals and antioxidant metabolites of its fruits. Data on bioactive metabolites from fruits and leaves, which are commonly consumed in soups and salads, are scarce and sometimes even contradictory. By means of NMR, the present study identified the specialised products contained in an Italian cultivar of L...
September 6, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28887216/phytochemistry-pharmacology-quality-control-and-future-research-of-forsythia-suspensa-thunb-vahl-a-review
#12
REVIEW
Zhaoyi Wang, Qing Xia, Xin Liu, Wenxue Liu, Wanzhen Huang, Xue Mei, Jun Luo, Mingxu Shan, Zhiqiang Ma, Ruichao Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Forsythiae Fructus (called Lianqiao in Chinese), the fruit of Forsythia suspensa (Thunb.) Vahl, is utilized as a common traditional medicine in China, Japan and Korea. It is traditionally used to treat pyrexia, inflammation, gonorrhea, carbuncle and erysipelas. Depending on the different harvest time, Forsythiae Fructus can be classified into two forms, namely Qingqiao and Laoqiao. The greenish fruits that start to ripen are collected as Qingqiao, while the yellow fruits that are fully ripe are collected as Laoqiao...
September 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28881278/deciphering-the-interplay-among-genotype-maturity-stage-and-low-temperature-storage-on-phytochemical-composition-and-transcript-levels-of-enzymatic-antioxidants-in-prunus-persica-fruit
#13
George A Manganaris, Pavlina Drogoudi, Vlasios Goulas, Georgia Tanou, Egli C Georgiadou, George E Pantelidis, Konstantinos A Paschalidis, Vasileios Fotopoulos, Athanasios Manganaris
The aim of this study was to understand the antioxidant metabolic changes of peach (cvs. 'Royal Glory', 'Red Haven' and 'Sun Cloud') and nectarine fruits (cv. 'Big Top') exposed to different combinations of low-temperature storage (0, 2, 4 weeks storage at 0 °C, 90% R.H.) and additional ripening at room temperature (1, 3 and 5 d, shelf life, 20 °C) with an array of analytical, biochemical and molecular approaches. Initially, harvested fruit of the examined cultivars were segregated non-destructively at advanced and less pronounced maturity stages and qualitative traits, physiological parameters, phytochemical composition and antioxidant capacity were determined...
August 24, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28880226/quantitative-analysis-extraction-optimization-and-biological-evaluation-of-cudrania-tricuspidata-leaf-and-fruit-extracts
#14
Seung-Hui Song, Sung Hwan Ki, Dae-Hun Park, Hong-Seop Moon, Chang-Dai Lee, In-Soo Yoon, Seung-Sik Cho
Cudrania tricuspidata Bureau (Moraceae) shows numerous pharmacological effects and has been used in traditional herbal remedies for inflammation, gastritis, tumors, and liver diseases. However, no validated analytical method for the standardization and optimization of the biological properties of C. tricuspidata preparations has been reported. We developed and validated a reverse-phase high-performance liquid chromatography (HPLC) method for the separation and quantification of active markers. Ethanolic extracts of C...
September 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28878590/enzymatically-modified-isoquercitrin-supplementation-intensifies-plantaris-muscle-fiber-hypertrophy-in-functionally-overloaded-mice
#15
Akiko Kohara, Masanao Machida, Yuko Setoguchi, Ryouichi Ito, Masanori Sugitani, Hiroko Maruki-Uchida, Hiroyuki Inagaki, Tatsuhiko Ito, Naomi Omi, Tohru Takemasa
BACKGROUND: Enzymatically modified isoquercitrin (EMIQ) is produced from rutin using enzymatic hydrolysis followed by treatment with glycosyltransferase in the presence of dextrin to add glucose residues. EMIQ is absorbed in the same way as quercetin, a powerful antioxidant reported to prevent disused muscle atrophy by targeting mitochondria and to have ergogenic effects. The present study investigated the effect of EMIQ on skeletal muscle hypertrophy induced by functional overload. METHODS: In Study 1, 6-week-old ICR male mice were divided into 4 groups: sham-operated control, sham-operated EMIQ, overload-operated control, and overload-operated EMIQ groups...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28878178/microwave-assisted-extraction-of-natural-antioxidants-from-the-exotic-gordonia-axillaris-fruit-optimization-and-identification-of-phenolic-compounds
#16
Ya Li, Sha Li, Sheng-Jun Lin, Jiao-Jiao Zhang, Cai-Ning Zhao, Hua-Bin Li
Our previous study reported that the fruit of Gordonia axillaris , an edible wild fruit, possessed strong antioxidant activity. In this study, a microwave-assisted extraction (MAE) method was established to extract antioxidants from the fruit of Gordonia axillaris . The influence of five parameters, including ethanol concentration, solvent/material ratio, extraction time, extraction temperature and microwave power, was investigated by single-factor experiments. Three factors, namely ethanol concentration, solvent/material ratio, extraction time, were found to exert a major influence on extraction efficacy, and were further studied by response surface methodology to investigate their interactions...
September 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28876034/-purification-characterization-and-partial-primary-structure-analysis-of-rutin-degrading-enzyme-in-tartary-buckwheat-seeds
#17
Yuwei Zhang, Jie Li, Yong Yuan, Jijuan Gu, Peng Chen
Rutin-degrading enzymes (RDE) can degrade rutin into poorly water soluble compound, quercetin, and cause the bitter taste in tartary buckwheat. In the present study RDE from Yu 6-21 tartary buckwheat seeds was purified by ammonium sulphate precipitation, followed by hydrophobic interaction chromatography on Phenyl Sepharose CL-4B, ion exchange chromatography on CM-Cellulose and gel filtration chromatography on Sephadex G-150. Purified RDE showed single band with molecular weight of 66 kDa on SDS-PAGE. The optimum pH and temperature of RDE were 5...
May 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28873762/the-novel-contributors-of-anti-diabetic-potential-in-mulberry-polyphenols-revealed-by-uhplc-hr-esi-tof-ms-ms
#18
Fuhua Li, Bin Zhang, Gu Chen, Xiong Fu
To explore the comprehensive phenolic profile of mulberry (Morus alba L.) fruit and reveal the novel anti-diabetic constituents, mulberry polyphenols (MP) were fractionated through gradient ethanol elution and subjected to composition and bioactivity analysis. Forty-seven phenolic compounds were identified and quantified through UHPLC-HR-ESI-TOF-MS/MS, including twenty-one newly identified compounds such as delphinidin 3-rutinoside-5-glucoside and cyanidin 3-rutinoside dimer. The antioxidant activity and anti-diabetic potential of fractionated MP were analyzed in vitro and ex vivo with HepG2 and pancreatic β-cell RIN-m5F...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28873552/polyphenol-and-l-ascorbic-acid-content-in-tomato-as-influenced-by-high-lycopene-genotypes-and-organic-farming-at-different-environments
#19
Raúl Martí, Miguel Leiva-Brondo, Inmaculada Lahoz, Carlos Campillo, Jaime Cebolla-Cornejo, Salvador Roselló
The accumulation of polyphenols and l-ascorbic acid was evaluated under conventional (integrated pest management, IPM) and organic farming, as means to increase the accumulation of chemoprotective compounds. The effect of genotype was considerably higher than the growing system, in fact it is determining. 'Kalvert', a high-lycopene cultivar, outstood for the accumulation of most polyphenols, though low-carotenoid cultivars with high accumulation were also detected. Organic farming significantly increased the levels of caffeic acid by 20%, but reduced those of ferulic acid and naringenin by 13% and 15% respectively...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28872373/anticarcinogenic-activity-of-muntingia-calabura-leaves-methanol-extract-against-the-azoxymethane-induced-colon-cancer-in-rats-involved-modulation-of-the-colonic-antioxidant-system-partly-by-flavonoids
#20
Nur Liana Md Nasir, Noorsyaza Eddrina Kamsani, Norhafizah Mohtarrudin, Fezah Othman, Siti Farah Md Tohid, Zainul Amiruddin Zakaria
CONTEXT: Leaves of Muntingia calabura (Elaeocarpaceae) are widely used in traditional medical practice; scientific findings show various pharmacological activities. However, its anticancer effect has not been investigated thoroughly yet. OBJECTIVE: The objective of this study is to study the chemoprevention effects of MEMCL against azoxymethane (AOM)-induced colon cancer and to examine the involvement of endogenous antioxidants Materials and methods: Male Sprague-Dawley rats, divided into five groups (n = 7), were injected intraperitoneally once weekly for 2 weeks with 15 mg/kg AOM, except for the normal group (received saline)...
December 2017: Pharmaceutical Biology
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