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https://www.readbyqxmd.com/read/28228098/anti-obesity-effect-of-ethanolic-extract-from-cosmos-caudatus-kunth-leaf-in-lean-rats-fed-a-high-fat-diet
#1
Hafeedza Abdul Rahman, Najla Gooda Sahib, Nazamid Saari, Faridah Abas, Amin Ismail, Muhammad Waseem Mumtaz, Azizah Abdul Hamid
BACKGROUND: Obesity is a major health concern both in developed and developing countries. The use of herbal medicines became the subject of interest for the management of obesity due to its natural origin, cost effectiveness and minimal side effects. The present study aimed at investigating anti-obesity potential of ethanolic extract from Cosmos caudatus Kunth leaf (EECCL). METHODS: In this study, the rats were randomly divided into six groups i.e., (1) Normal Diet (ND); (2) Normal Diet and 175 mg/kgBW of EECCL (ND + 175 mg/kgBW); (3) Normal Diet and 350 mg/kgBW of EECCL (ND + 350 mg/kgBW); (4) High Fat Diet (HFD); (5) High Fat Diet and 175 mg/kgBW of EECCL (HFD + 175 mg/kgBW); (6) High Fat Diet and 350 mg/kgBW of EECCL (HFD + 350 mg/kgBW)...
February 22, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28226292/hplc-dad-qtof-ms-profiling-of-phenolics-from-leaf-extracts-of-two-tunisian-fig-cultivars-potential-as-a-functional-food
#2
Olfa Belguith-Hadriche, Sonda Ammar, María Del Mar Contreras, Hamadi Fetoui, Antonio Segura-Carretero, Abdelfattah El Feki, Mohamed Bouaziz
The phenolic constituents of the aqueous-ethanolic extract of two Tunisian Ficus carica leaves cultivars and their hypoglycaemic, hypolipidaemic and antioxidative activities in alloxan-induced diabetic rats were investigated. Our results demonstrated that the treatment with the leaves extracts of F. carica improved lipid profile and reduced blood glucose level as well as thiobarbituric acid-reactive substances content. The antioxidant enzymes activity in the liver and heart tissues of diabetic rats was increased after the treatment...
February 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28223131/constituent-analysis-of-the-ethanol-extracts-of-chimonanthus-nitens-oliv-leaves-and-their-inhibitory-effect-on-%C3%AE-glucosidase-activity
#3
Hui Chen, Kehui Ouyang, Yan Jiang, Zhanwei Yang, Wenbing Hu, Lei Xiong, Ning Wang, Xin Liu, Wenjun Wang
The ethanol extracts of Chimonanthus nitens Oliv. leaves were prepared sequentially by ethanol gradient elution and tested for their α-glucosidase inhibitory. The fraction of 50% ethanol eluate (EE) exhibited the notable inhibition with IC50 of 0.376mg/mL. Also, 50% EE was chemically characterized by liquid chromatography-mass spectrometry (LC-MS) analysis. Eight compounds including rutin (1), hyperin (2), isoquercitrin (3), luteoloside (4), astragalin (6), quercetin (13), naringenin (14), kaempferol (15) were identified by compared with standard substances as well as proper luteolin-5-O-glucoside (5), kaempferol-7-O-rhamnoside (9), 5,7,8-trihydroxy-2-methoxyl-flavone-7-O-glucoside (10), kaempferol-7-O-acetyl-galactoside (11)...
February 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28218717/ultrasound-assisted-extraction-and-identification-of-natural-antioxidants-from-the-fruit-of-melastoma-sanguineum-sims
#4
Tong Zhou, Dong-Ping Xu, Sheng-Jun Lin, Ya Li, Jie Zheng, Yue Zhou, Jiao-Jiao Zhang, Hua-Bin Li
The fruit of Melastoma sanguineum Sims is an edible and sweet wild fruit. In our previous study, the fruit was found to have a strong antioxidant property. In this study, an ultrasound-assisted extraction (UAE) method was developed to extract natural antioxidants from the fruit of Melastoma sanguineum Sims, and a response surface methodology was used to optimize the conditions of UAE to maximize the extraction efficiency. The influence of five independent extraction parameters (ethanol concentration, solvent/material ratio, extracting time, temperature, and ultrasound power) on the extraction efficiency were investigated using a single factor experiment, and then a central composite rotatable design was used to investigate the interaction of three key parameters...
February 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28216899/antiprotozoal-constituents-from-annona-cherimola-miller-a-plant-used-in-mexican-traditional-medicine-for-the-treatment-of-diarrhea-and-dysentery
#5
Fernando Calzada, Jose Correa-Basurto, Elizabeth Barbosa, David Mendez-Luna, Lilian Yepez-Mulia
BACKGROUND: Annona cherimola Miller (Annonaceae) is a medicinal plant frequently recommended in Mexican traditional medicine for the treatment of gastrointestinal disorders such as diarrhea and dysentery. OBJECTIVE: This work was undertaken to obtain information that support the traditional use of A. cherimola, on pharmacological basis using in vitro and computational experiments. MATERIAL AND METHODS: Bioassay-guided fractionation of the ethanol extract of the leaves of A...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28216897/high-performance-liquid-chromatography-diode-array-detector-method-for-the-simultaneous-determination-of-five-compounds-in-the-pulp-and-seed-of-sea-buckthorn
#6
Lu Zhao, E Wen, Halmuart Upur, Shuge Tian
CONTEXT: Sea buckthorn (Hippophae rhamnoides L.) as a traditional Chinese medicinal plant has various uses in Xinjiang. OBJECTIVE: A reversed-phase rapid-resolution liquid-chromatography method with diode array detector was developed for simultaneous determination of protocatechuic acid, rutin, quercetin, kaempferol, and isorhamnetin in the pulp and seed of sea buckthorn, a widely used traditional Chinese medicine for promoting metabolism and treating scurvy and other diseases...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28213661/biotransformation-of-rutin-using-crude-enzyme-from-rhodopseudomonas-palustris
#7
Chun-Jie Guan, Yu-Jia Ji, Jia-Lin Hu, Chao-Nan Hu, Fei Yang, Guan-E Yang
Rhodopseudomonas palustris was selected for the ability to grow in diglycosylated flavonoids-based media, exhibited deglycosylation activity. The present study aimed to investigate the ability of a crude enzyme from Rhodopseudomonas palustris to transform rutin. Our results showed the crude enzyme was found to transform rutin to quercetin via isoquercitrin. The maximum enzyme activities were observed at pH 7.0, 25 °C, and rutin concentration of 1.0 mg mL(- 1). Under optimal conditions, 13.11 μM rutin was biotransformed into 6...
February 17, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28208718/on-line-screening-isolation-and-identification-of-antioxidant-compounds-of-helianthemum-ruficomum
#8
Yasmine Chemam, Samir Benayache, Eric Marchioni, Minjie Zhao, Paul Mosset, Fadila Benayache
Many Helianthemum species (Cistaceae) are recognized for their various medicinal virtues. Helianthemum ruficomum is an endemic species to the septentrional Sahara on which no report is available so far. The purpose of this work was to investigate the chemical composition and the radical scavenging capacity of this species and its isolated components. Collected from Mougheul (south-west of Algeria), the aerial parts were macerated with 80% EtOH/H₂O, after evaporation, the remaining extract was diluted with H₂O and extracted with petroleum ether, chloroform, ethyl acetate and n-butanol...
February 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28205590/antifouling-potential-of-nature-inspired-sulfated-compounds
#9
Joana R Almeida, Marta Correia-da-Silva, Emília Sousa, Jorge Antunes, Madalena Pinto, Vitor Vasconcelos, Isabel Cunha
Natural products with a sulfated scaffold have emerged as antifouling agents with low or nontoxic effects to the environment. In this study 13 sulfated polyphenols were synthesized and tested for antifouling potential using the anti-settlement activity of mussel (Mytilus galloprovincialis) plantigrade post-larvae and bacterial growth inhibition towards four biofilm-forming bacterial strains. Results show that some of these Nature-inspired compounds were bioactive, particularly rutin persulfate (2), 3,6-bis(β-D-glucopyranosyl) xanthone persulfate (6), and gallic acid persulfate (12) against the settlement of plantigrades...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28199789/cholesterol-lowering-activity-of-tartary-buckwheat-protein
#10
Chengnan Zhang, Rui Zhang, Yuk Man Li, Ning Liang, Yimin Zhao, Hanyue Zhu, Zouyan He, Jianhui Liu, Wangjun Hao, Rui Jiao, Ka Ying Ma, Zhen-Yu Chen
Previous research has shown that Tartary buckwheat flour is capable of reducing plasma cholesterol. The present study was to examine the effect of rutin and Tartary buckwheat protein on plasma total cholesterol (TC) in hypercholesterolemia hamsters. In the first animal experiment, 40 male hamsters were divided into four groups fed either the control diet or one of the three experimental diets containing 8.2 mmol rutin, 8.2 mmol quercetin, or 2.5 g kg(-1) cholestyramine, respectively. Results showed that only cholestyramine but not rutin and its aglycone quercetin decreased plasma TC, which suggested that rutin was not the active ingredient responsible for plasma TC-lowering activity of Tartary buckwheat flour...
February 24, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28197528/antimutagenic-effect-of-hibiscus-sabdariffa-l-aqueous-extract-on-rats-treated-with-monosodium-glutamate
#11
Ana Carla Guidini Valentini Gheller, Jacqueline Kerkhoff, Gerardo Magela Vieira Júnior, Kleber Eduardo de Campos, Marina Mariko Sugui
Hibiscus sabdariffa L. is a plant of the Malvaceae family, commonly known as roselle. H. sabdariffa is known to contain antioxidant, cholesterol-lowering, antiobesity, insulin resistance reduction, antihypertensive, and skin cancer chemopreventive properties. This study evaluated the effects of H. sabdariffa aqueous extract against cyclophosphamide (CPA, 25 mg/Kg) induced damage to DNA in male Wistar rats by micronucleus test. Samples of H. sabdariffa calyx were obtained in the municipality of Barra do Garças, Mato Grosso, Brazil...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/28194111/syringa-oblata-lindl-aqueous-extract-is-a-potential-biofilm-inhibitor-in-s-suis
#12
Jingwen Bai, Yanbei Yang, Shuai Wang, Lingfei Gao, Jianqing Chen, Yongzhi Ren, Wenya Ding, Ishfaq Muhammad, Yanhua Li
Streptococcus suis (S. suis) is a zoonotic pathogen that causes severe disease symptoms in pigs and humans. Syringa oblata Lindl. distributed in the middle latitudes of Eurasia and North America were proved as the most development potential of Chinese Medicine. In this study, biofilm formation by S. suis decreased after growth with 1/2 MIC, 1/4 MIC, or 1/8 MIC of Syringa oblata Lindl. aqueous extract and rutin. Scanning electron microscopy analysis revealed the potential effect of Syringa oblata Lindl. aqueous extract and rutin against biofilm formation by S...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28192136/inhibition-of-glycation-and-aldose-reductase-activity-using-dietary-flavonoids-a-lens-organ-culture-studies
#13
Kapil K Patil, Rajesh N Gacche
On the eve of increasing incidence of diabetes mellitus and related complications, the search for novel, safe and alternatives therapeutic approaches are evolving. In the present investigation, a panel of ten dietary flavonoids such as 4'-methoxyflavanone, formononetin, hesperetin, hesperidin, naringenin, naringin, rutin, diadzin, silibinin and silymarin was evaluated as possible inhibitors of sugar induced cataractogenesis using bovine lens organ culture studies. The effect of selected flavonoids was observed on glycation induced lens opacity, AGE fluorescence, carbonyl group formation (a biomarker of glycation), protein aggregation and aldose reductase (AR) inhibition...
February 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28186391/a-sustainable-one-pot-two-enzymes-synthesis-of-naturally-occurring-arylalkyl-glucosides
#14
Ivan Bassanini, Jana Krejzova, Walter Panzeri, Daniela Monti, Vladimir Kren, Sergio Riva
A sustainable, convenient and scalable one-pot two-enzymes method for the glucosylation of arylalkyl alcohols has been developed. The reaction scheme is based on a transrutinosylation catalyzed by a rutinosidase from A. niger using the cheap commercially available natural flavonoid rutin as glycosyl donor, followed by a selective 'trimming' of the rutinoside unit catalyzed by a rhamnosidase from A. terreus. The process has been validated with the syntheses of several natural bioactive glucosides, that could be isolated in up to 75 % yield avoiding silica gel chromatography...
February 10, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28182841/bioactive-components-and-antioxidant-capacity-of-fruits-from-nine-sorbus-genotypes
#15
Maja Mikulic-Petkovsek, Boris Krska, Biljana Kiprovski, Robert Veberic
In this study, biochemical profile of fruits of 9 Sorbus genotypes was analyzed. The content of total sugars ranged from 69.7 g/kg ('Titan') to 217.5 g/kg (Sorbus torminalis) and total organic acids from 17.7 g/kg ('Businka') to 40.2 g/kg (S. torminalis). The highest content of total anthocyanins had 'Burka' (871 mg/kg FW) and 'Businka' (856 mg/kg FW). Quercetin derivatives represented more than 95% of total flavonols. 'Alaja krupnaja' had 3.5- to 29-fold higher rutin content than other analyzed genotypes. S...
February 9, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28178749/improving-on-nature-the-role-of-nanomedicine-in-the-development-of-clinical-natural-drugs
#16
Anna Rita Bilia, Vieri Piazzini, Clizia Guccione, Laura Risaliti, Martina Asprea, Giada Capecchi, Maria Camilla Bergonzi
Natural products have been used as a major source of drugs for millennia, and about half of the pharmaceuticals in use today are derived from natural products. However, their efficacy can be limited because of their low hydrophilicity and intrinsic dissolution rate(s), or physical/chemical instability. In addition, they can present scarce absorption, poor pharmacokinetics and bioavailability, scarce biodistribution, first-pass metabolism, trivial penetration and accumulation in the organs of the body, or low targeting efficacy...
February 8, 2017: Planta Medica
https://www.readbyqxmd.com/read/28177791/influence-of-i-rhizoglomus-irregulare-i-on-nutraceutical-quality-and-regeneration-of-i-lycium-barbarum-i-leaves-under-salt-stress
#17
Hongguang Liu, Yajun Wang, Hui Chen, Ming Tang
Whether arbuscular mycorrhizal fungi (AMF) augment the nutraceutical quality of crops under salt stress is critical as a potential agronomic practice in salinized farmland. To evaluate the effect of <i>Rhizoglomus irregulare</i> on the nutraceutical quality of <i>Lycium barbarum</i> leaves under salt stress, growth parameters, rutin, polysaccharide, acidic polysaccharide and amino acids of two harvests were analyzed. Inoculation of <i>R. irregulare</i> significantly increased the regenerated bud number (PES=0...
January 12, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28168010/rutin-as-a-mediator-of-lipid-metabolism-and-cellular-signaling-pathways-interactions-in-fibroblasts-altered-by-uva-and-uvb-radiation
#18
Agnieszka Gęgotek, Paula Rybałtowska-Kawałko, Elżbieta Skrzydlewska
Background. Rutin is a natural nutraceutical that is a promising compound for the prevention of UV-induced metabolic changes in skin cells. The aim of this study was to examine the effects of rutin on redox and endocannabinoid systems, as well as proinflammatory and proapoptotic processes, in UV-irradiated fibroblasts. Methods. Fibroblasts exposed to UVA and UVB radiation were treated with rutin. The activities and levels of oxidants/antioxidants and endocannabinoid system components, as well as lipid, DNA, and protein oxidation products, and the proinflammatory and pro/antiapoptotic proteins expression were measured...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28166708/potential-anti-inflammatory-antioxidant-and-antimicrobial-activities-of-sambucus-australis
#19
Jhéssica Benevides Bahiense, Franciane Martins Marques, Mariana Moreira Figueira, Thais Souza Vargas, Tamara P Kondratyuk, Denise Coutinho Endringer, Rodrigo Scherer, Marcio Fronza
CONTEXT: Sambucus australis Cham. & Schltdl. (Adoxaceae) is used in Brazilian folk medicine to treat inflammatory disorders. OBJECTIVE: To evaluate the in vitro anti-inflammatory, antioxidant and antimicrobial properties of S. australis. MATERIALS AND METHODS: The anti-inflammatory activity of ethanol extracts of the leaf and bark of S. australis (1-100 μg/mL) were studied in lipopolysaccharide/interferon γ stimulated murine macrophages RAW 264...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28165019/fungal-endophyte-derived-fritillaria-unibracteata-var-wabuensis-diversity-antioxidant-capacities-in-vitro-and-relations-to-phenolic-flavonoid-or-saponin-compounds
#20
Feng Pan, Tian-Jiao Su, Shi-Mei Cai, Wei Wu
Diverse fungal endophytes are rich fungal resources for the production of an enormous quantity of natural products. In the present study, 53 fungal endophytes were isolated from the bulbs of Fritillaria unibracteata var. wabuensis (FUW). Of these, 49 strains were identified and grouped into 17 different taxa, and priority was conferred to the Fusarium genus. All fungal fermented filtrates displayed antioxidant activities. The DPPH activity, total antioxidant capacities (ABTS), reduction power (FRAP), total phenolic content (TPC), total flavonoid content (TFC) and total saponin content (TSC) were evaluated using petroleum ether, ethyl acetate, n-butyl alcohol and ethanol fractions extracted from five representative fungal cultures...
February 6, 2017: Scientific Reports
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