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https://www.readbyqxmd.com/read/28927132/downregulation-of-esophageal-cancer-related-gene-4-promotes-proliferation-and-migration-of-hepatocellular-carcinoma
#1
Shujian Ge, Yali Xu, Hongliang Wang, Yaxin Sun, Xiangguo Tian, Zhixin Cao, Xiaoyan Lin, Jiawen Xu, Qiangxiu Wang
Esophageal cancer-related gene 4 (ECRG4) is a candidate tumor suppressor gene, which is involved in cell apoptosis, migration, infection and inflammation responsiveness; however, its expression level and clinical significance in hepatocellular carcinoma (HCC) remains unclear. In the present study, the authors aim to evaluate the clinical significance and potential role of ECRG4 in HCC. Level of ECRG4 protein expression in HCC and peripheral tissues was investigated in tissue specimens obtained from 56 consecutive HCC patients by immunohistochemistry...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28920418/myogenic-satellite-cells-differentiation-with-linolenic-and-retinoic-and-thiazolidenediones-from-prepubertal-korean-black-goat
#2
Sugathan Subi, Sungjin Lee, Supriya Shiwani, Naresh Kumar Singh
Objective: Myogenic satellite cells were isolated from semitendinosus muscle of prepubertal Korean black goat to observe the differential effect of linolenic and retinoic acid in thepresence of thiazolidinediones and also to observe the production insulin sensitive preadipocyte. Methods: Cells were characterized for its stemness with CD 34, CD 13, CD 106, CD44, Vimentin surface markers using flow cytometry. Cells characterized themselves to possess significant (p<0...
September 18, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28917653/human-il6-stimulates-bovine-satellite-cell-proliferation-through-a-signal-transducer-and-activator-of-transcription-3-stat3-dependent-mechanism
#3
A M Brandt, J M Kania, B M Reinholt, S E Johnson
Bovine satellite cell (bSC) myogenesis and skeletal muscle hypertrophy occur through the orchestrated actions of multiple autocrine and paracrine growth factors. Intimate to the bSC niche is IL6, a dual-purpose cytokine with proinflammatory and mitogenic properties. The objective of the experiment was to examine the effects of IL6 on proliferation and differentiation of bSC in vitro. Treatment of primary bSC cultures with recombinant bovine IL6 (bIL6) failed to alter myogenesis owing to the absence of intracellular signal transduction...
August 31, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28902980/myoglobin-and-polydopamine-engineered-raman-nanoprobes-for-detecting-imaging-and-monitoring-reactive-oxygen-species-in-biological-samples-and-living-cells
#4
Sumit Kumar, Amit Kumar, Gyeong-Hwan Kim, Won-Kyu Rhim, Kevin L Hartman, Jwa-Min Nam
Highly reliable detection, imaging, and monitoring of reactive oxygen species (ROS) are critical for understanding and studying the biological roles and pathogenesis of ROS. This study describes the design and synthesis of myoglobin and polydopamine-engineered surface-enhanced Raman scattering (MP-SERS) nanoprobes with strong, tunable SERS signals that allow for specifically detecting and imaging ROS sensitively and quantitatively. The study shows that a polydopamine nanolayer can facilitate the modification of Raman-active myoglobins and satellite Au nanoparticles (s-AuNPs) to a plasmonic core AuNP (c-AuNP) in a controllable manner and the generation of plasmonically coupled hot spots between a c-AuNP and s-AuNPs that can induce strong SERS signals...
September 13, 2017: Small
https://www.readbyqxmd.com/read/28898948/long-term-characteristics-of-satellite-based-pm2-5-over-east-china
#5
Qianshan He, Fuhai Geng, Chengcai Li, Shiqi Yang, Yanyu Wang, Haizhen Mu, Guangqiang Zhou, Xiaobo Liu, Wei Gao, Tiantao Cheng, Zheng Wu
With the explosive economic development of China over the past few decades, air pollution has become a serious environmental problem and has attracted increasing global concern. Using satellite-based PM2.5 data from 2000 to 2015, we found that the temporal-spatial variation of PM2.5 in East China is characterized by high concentrations in the northern part and low concentrations in the southern part of East China, and by being seasonally high in autumn and winter but low in spring and summer. We also found that the regional average PM2...
September 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28893664/single-cell-transcriptome-analysis-of-muscle-satellite-cells-reveals-widespread-transcriptional-heterogeneity
#6
Dong Seong Cho, Jason D Doles
Tissue specific stem cells are indispensable contributors to adult tissue maintenance, repair, and regeneration. In skeletal muscle, satellite cells (SCs) are the resident muscle stem cell population and are required to maintain skeletal muscle homeostasis throughout life. Increasing evidence suggests that SCs are a heterogeneous cell population with substantial biochemical and functional diversity. A major limitation in the field is an incomplete understanding of the nature and extent of this cellular heterogeneity...
September 8, 2017: Gene
https://www.readbyqxmd.com/read/28887614/the-pro-fibrotic-connective-tissue-growth-factor-ctgf-ccn2-correlates-with-the-number-of-necrotic-regenerative-foci-in-dystrophic-muscle
#7
María Gabriela Morales, María José Acuña, Daniel Cabrera, Roel Goldschmeding, Enrique Brandan
Connective tissue growth factor (CTGF/CCN2) has strong inflammatory and profibrotic activities. Its expression is enhanced in skeletal muscular dystrophies such as Duchenne muscular dystrophy (DMD), a myopathy characterized by exacerbated inflammation and fibrosis. In dystrophic tissue, necrotic-regenerative foci, myofibroblasts, newly-regenerated muscle fibers and necrosis all occur simultaneously. To determine if CCN2 is involved in the appearance of the foci, we studied their presence and characteristics in mdx mice (DMD mouse model) compared to mdx mice hemizygous for CCN2 (mdx-Ccn2+/-)...
September 8, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28886132/a-global-view-of-shifting-cultivation-recent-current-and-future-extent
#8
Andreas Heinimann, Ole Mertz, Steve Frolking, Andreas Egelund Christensen, Kaspar Hurni, Fernando Sedano, Louise Parsons Chini, Ritvik Sahajpal, Matthew Hansen, George Hurtt
Mosaic landscapes under shifting cultivation, with their dynamic mix of managed and natural land covers, often fall through the cracks in remote sensing-based land cover and land use classifications, as these are unable to adequately capture such landscapes' dynamic nature and complex spectral and spatial signatures. But information about such landscapes is urgently needed to improve the outcomes of global earth system modelling and large-scale carbon and greenhouse gas accounting. This study combines existing global Landsat-based deforestation data covering the years 2000 to 2014 with very high-resolution satellite imagery to visually detect the specific spatio-temporal pattern of shifting cultivation at a one-degree cell resolution worldwide...
2017: PloS One
https://www.readbyqxmd.com/read/28885620/oxidative-stress-induced-s100b-accumulation-converts-myoblasts-into-brown-adipocytes-via-an-nf-%C3%AE%C2%BAb-yy1-mir-133-axis-and-nf-%C3%AE%C2%BAb-yy1-bmp-7-axis
#9
Giulio Morozzi, Sara Beccafico, Roberta Bianchi, Francesca Riuzzi, Ilaria Bellezza, Ileana Giambanco, Cataldo Arcuri, Alba Minelli, Rosario Donato
Muscles of sarcopenic people show hypotrophic myofibers and infiltration with adipose and, at later stages, fibrotic tissue. The origin of infiltrating adipocytes resides in fibro-adipogenic precursors and nonmyogenic mesenchymal progenitor cells, and in satellite cells, the adult stem cells of skeletal muscles. Myoblasts and brown adipocytes share a common Myf5(+) progenitor cell: the cell fate depends on levels of bone morphogenetic protein 7 (BMP-7), a TGF-β family member. S100B, a Ca(2+)-binding protein of the EF-hand type, is expressed at relatively high levels in myoblasts from sarcopenic humans and exerts anti-myogenic effects via NF-κB-dependent inhibition of MyoD, a myogenic transcription factor acting upstream of the essential myogenic factor, myogenin...
September 8, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28883094/coordinate-roles-for-itg%C3%AE-8-and-pcdh15-in-the-regulation-of-cilia-biogenesis-in-sensory-cells
#10
Linda Goodman, Marisa Zallocchi
The organism's perception of its surroundings depends on sensory systems and the highly specialized cilia present in the neurosensory cells. Here, we described the existence of an integrin alpha 8 (Itga8)/protocadherin-15a (Pcdh15a) ciliary complex in neuromast hair cells. Depletion of the complex via down-regulation or loss of function mutations leads to a dysregulation of cilia biogenesis and endocytosis. At the molecular level, removal of the complex blocks the access of Rab8a into the cilia as well as normal recruitment of ciliary cargo by centriolar satellites...
September 7, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28872121/minimally-invasive-muscle-embedding-mime-a-novel-experimental-technique-to-facilitate-donor-cell-mediated-myogenesis
#11
Joseph A Roche, Morium Begam, Sujay S Galen
Skeletal muscle possesses regenerative capacity due to tissue-resident, muscle-fiber-generating (myogenic) satellite cells (SCs), which can form new muscle fibers under the right conditions. Although SCs can be harvested from muscle tissue and cultured in vitro, the resulting myoblast cells are not very effective in promoting myogenesis when transplanted into host muscle. Surgically exposing the host muscle and grafting segments of donor muscle tissue, or the isolated muscle fibers with their SCs onto host muscle, promotes better myogenesis compared to myoblast transplantation...
August 24, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28869573/effects-of-whey-soy-or-leucine-supplementation-with-12-weeks-of-resistance-training-on-strength-body-composition-and-skeletal-muscle-and-adipose-tissue-histological-attributes-in-college-aged-males
#12
C Brooks Mobley, Cody T Haun, Paul A Roberson, Petey W Mumford, Matthew A Romero, Wesley C Kephart, Richard G Anderson, Christopher G Vann, Shelby C Osburn, Coree D Pledge, Jeffrey S Martin, Kaelin C Young, Michael D Goodlett, David D Pascoe, Christopher M Lockwood, Michael D Roberts
We sought to determine the effects of L-leucine (LEU) or different protein supplements standardized to LEU (~3.0 g/serving) on changes in body composition, strength, and histological attributes in skeletal muscle and adipose tissue. Seventy-five untrained, college-aged males (mean ± standard error of the mean (SE); age = 21 ± 1 years, body mass = 79.2 ± 0.3 kg) were randomly assigned to an isocaloric, lipid-, and organoleptically-matched maltodextrin placebo (PLA, n = 15), LEU (n = 14), whey protein concentrate (WPC, n = 17), whey protein hydrolysate (WPH, n = 14), or soy protein concentrate (SPC, n = 15) group...
September 4, 2017: Nutrients
https://www.readbyqxmd.com/read/28869034/plasticity-and-function-of-human-skeletal-muscle-in-relation-to-disuse-and-rehabilitation-influence-of-ageing-and-surgery
#13
Charlotte Suetta
In order to study the influence of disuse and aging on skeletal muscle homeostasis, different human models were employed. Effects of chronic disuse were investigated in elderly patients suffering from uni-lateral hip-osteoarthritis, whereas the effect of short-term disuse (4 and 14 days of unilateral lower limb immobilisation) was assessed in healthy young and old individuals. In summary, chronic muscle disuse in the elderly was associated with marked quantitative as well as qualitative neuromuscular impairments...
August 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28867121/hierarchical-signaling-transduction-of-the-immune-and-muscle-cell-crosstalk-in-muscle-regeneration
#14
Wenjun Yang, Ping Hu
The muscle regeneration is a complicated bioprocess that involved in many cell types, including necrotic muscle cells, satellite cells, mesenchymal cells, pericytes, immune cells, and other cell types present at the injury site. Immune cells involved in both innate and adaptive immune responses regulate the progress of muscle regeneration. In this review, we discussed the roles of different immune cells in muscle regeneration. The immune cells regulate muscle regeneration through cytokine production, cell-cell contacts, and general immune environment regulation...
August 24, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28866195/polyglycerol-mediated-covalent-construction-of-magnetic-mesoporous-silica-nanohybrid-with-aqueous-dispersibility-for-drug-delivery
#15
Xiaoxin Yang, Yu Wen, Anqing Wu, Meiyun Xu, Tsukuru Amano, Luyi Zheng, Li Zhao
Construction of nanohybrids with chemical and colloidal stability is of great importance for the exploration of their potential applications in biomedical field. In this work, a versatile strategy based on polyglycerol (PG) mediated covalent linkage is developed to fabricate a core-satellite nanohybrid, termed MMSN, consisting of a mesoporous silica nanoparticle (MSN) as a core and many superparamagnetic iron oxide nanoparticles (SPION) on the outer surface. In this synthetic strategy, the PG grafted SPION is derivatized to convert partial periphery hydroxyl groups to carboxyl moieties, followed by attachment to aminated MSN through amide bonds...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28864379/overexpression-of-heparin-binding-epidermal-growth-factor-like-growth-factor-mediates-liver-fibrosis-in-transgenic-mice
#16
Yongze Guo, Qian Ding, Lei Chen, Chenguang Ji, Huiyao Hao, Jia Wang, Wei Qi, Xiaoli Xie, Junji Ma, Aidi Li, Xiaoyu Jiang, Xiaotian Li, Huiqing Jiang
BACKGROUND: The role of heparin-binding epidermal growth factor-like growth factor (HB-EGF) in liver fibrosis is not clear and is sometimes even contradictory. To clarify this role, a HB-EGF transgenic (Tg) mouse model was, for the first time, used to evaluate the functions of HB-EGF in liver fibrosis. MATERIALS AND METHODS: For the in vivo study, carbon tetrachloride injection and bile duct ligation treatment were used to induce liver fibrosis in HB-EGF Tg mice and wild-type (WT) mice, respectively...
August 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28859084/regulation-of-myoblast-differentiation-by-metabolic-perturbations-induced-by-metformin
#17
Theodora Pavlidou, Marco Rosina, Claudia Fuoco, Giulia Gerini, Cesare Gargioli, Luisa Castagnoli, Gianni Cesareni
The metabolic perturbation caused by calorie restriction enhances muscle repair by playing a critical role in regulating satellite cell availability and activity in the muscles of young and old mice. To clarify the underlying mechanisms we asked whether myoblast replication and differentiation are affected by metformin, a calorie restriction-mimicking drug. C2C12, a mouse myoblast cell line, readily differentiate in vitro and fuse to form myotubes. However, when incubated with metformin, C2C12 slow their replication and do not differentiate...
2017: PloS One
https://www.readbyqxmd.com/read/28857242/down-regulation-of-the-long-noncoding-rna-hox-transcript-antisense-intergenic-rna-inhibits-the-occurrence-and-progression-of-glioma
#18
Bin Yang, Zhen-Yu Wei, Bang-Qing Wang, Hua-Chao Yang, Jun-Yi Wang, Xing-Yao Bu
This study aims to explore the role of long noncoding RNA (lncRNA)-HOX transcript antisense intergenic RNA (HOTAIR) in the occurrence and progression of glioma. Fresh glioma and normal brain tissues were classified into a glioma group (n = 67) and a normal group (n = 64) respectively. U87 cells were assigned into the blank, sh-NC and sh-HOTAIR groups. Quantitative real-time polymerase chain reaction (qRT-PCR) was utilized to determine HOTAIR expression. Cell proliferation, cell cycle and cell apoptosis rates were detected by cell counting kit-8 (CCK-8) and flow cytometry (FCM)...
August 31, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28854747/in-ovo-feeding-of-creatine-pyruvate-alters-energy-reserves-satellite-cell-mitotic-activity-and-myogenic-gene-expression-of-breast-muscle-in-embryos-and-neonatal-broilers
#19
M M Zhao, T Gao, L Zhang, J L Li, P A Lv, L L Yu, F Gao, G H Zhou
We investigated the effects of in ovo feeding (IOF) of creatine pyruvate (CrPyr) on energy reserves, satellite cell mitotic activity (SCMA) and myogenic gene expression in breast muscle of embryos and neonatal broilers. A total of 960 eggs were randomly allocated into three treatments: 1) non-injected control group, 2) saline group injected with 0.6 mL of physiological saline (0.75%), and 3) CrPyr group injected with 0.6 mL of physiological saline (0.75%) containing 12 mg CrPyr/egg at 17.5 d of incubation...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28842905/human-satellite-cell-isolation-and-xenotransplantation
#20
Steven M Garcia, Stanley Tamaki, Xiaoti Xu, Jason H Pomerantz
Satellite cells are mononucleated cells of the skeletal muscle lineage that exist beneath the basal lamina juxtaposed to the sarcolemma of skeletal muscle fibers. It is widely accepted that satellite cells mediate skeletal muscle regeneration. Within the satellite cell pool of adult muscle are skeletal muscle stem cells (MuSCs), also called satellite stem cells, which fulfill criteria of tissue stem cells: They proliferate and their progeny either occupies the adult MuSC niche during self-renewal or differentiates to regenerate mature muscle fibers...
2017: Methods in Molecular Biology
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