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Juhani H Määttä, Jaro Karppinen, Markus Paananen, Cora Bow, Keith D K Luk, Kenneth M C Cheung, Dino Samartzis
Low back pain (LBP) is the world's most disabling condition. Modic changes (MC) are vertebral bone marrow changes adjacent to the endplates as noted on magnetic resonance imaging. The associations of specific MC types and patterns with prolonged, severe LBP and disability remain speculative. This study assessed the relationship of prolonged, severe LBP and back-related disability, with the presence and morphology of lumbar MC in a large cross-sectional population-based study of Southern Chinese.We addressed the topographical and morphological dimensions of MC along with other magnetic resonance imaging phenotypes (eg, disc degeneration and displacement) on the basis of axial T1 and sagittal T2-weighted imaging of L1-S1...
May 2016: Medicine (Baltimore)
Branden L Eggan, Sarah E McCallum
Systemic 18-methoxycoronaridine, an alpha3beta4 nicotinic antagonist, slows the rate of induction of behavioral sensitization to nicotine (Glick et al., 1996; 2011). The primary mechanism of action of 18-MC is believed to be the inhibition of α3β4 nicotinic acetylcholine receptors which are densely expressed in the medial habenula and interpeduncular nucleus (Pace et al., 2004; Glick et al., 2012). Recently, these habenular nicotinic receptors and their multiple roles in nicotine aversion and withdrawal have been increasingly emphasized (Antolin-Fontes et al...
July 1, 2016: Behavioural Brain Research
Iffat Hassan, Parvaiz Anwar, Shagufta Rather, Farah Sameem, Imran Majid, Yasmeen Jabeen, Syed Mubashir, Nuzhatun Nisa, Qazi Masood
BACKGROUND: Changing trends of sexually transmitted infections (STI) and HIV/AIDS has been noted in the literature over years, depending to some extent on the geographical and cultural factors of the region. In Kashmir Valley also, the pattern of STI may be different from the rest of the country. AIMS OF THE STUDY: The aim was to present the experience with patterns of STI in Kashmir. MATERIALS AND METHODS: Retrospective hospital-based study carried out by detailed analysis of case records of 5-year period...
January 2015: Indian Journal of Sexually Transmitted Diseases
C Holmer, C Klinger, H J Buhr
BACKGROUND: Human and financial resources are increasingly bound due to economic pressure and the working hours Act whereby the already restricted further training times are further limited. The industry also has less funding available for sponsorship of conferences and workshops. Against this background the question arises whether a reduction or focusing of the conferences is necessary; therefore, the aim of this survey was to obtain an opinion from members of the German Society of General and Visceral Surgery (DGAV) and possibly to derive a need for action to submit to the board members...
November 2015: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Claudia D E de Bruin, N Margreth van der Lugt, Remco Visser, Wilma Oostdijk, Erik W van Zwet, Arjan B Te Pas, Enrico Lopriore
OBJECTIVE: Small-for-gestational-age (SGA) neonates (birth weight <10th centile) are at higher risk of altered glucose homeostasis compared to appropriate for gestational age (AGA) neonates. The aim of this matched case-control study was to estimate the incidence of hypoglycaemia and/or hyperglycaemia in monochorionic (MC) twins with selective intrauterine growth restriction (sIUGR). METHODS: We included all MC twins with sIUGR (2002-2013). Neonates in the SGA group were matched with their AGA co-twin...
2016: Journal of Maternal-fetal & Neonatal Medicine
Hiroshi Ohira, David H Birnie, Elena Pena, Jordan Bernick, Brian Mc Ardle, Eugene Leung, George A Wells, Keiichiro Yoshinaga, Ichizo Tsujino, Takahiro Sato, Osamu Manabe, Noriko Oyama-Manabe, Masaharu Nishimura, Nagara Tamaki, Alexander Dick, Carole Dennie, Ran Klein, Jennifer Renaud, Robert A deKemp, Terrence D Ruddy, Benjamin J W Chow, Ross Davies, Renee Hessian, Peter Liu, Rob S B Beanlands, Pablo B Nery
PURPOSE: Cardiac sarcoidosis (CS) is a cause of conduction system disease (CSD). (18)F-Fluorodeoxyglucose-positron emission tomography (FDG PET) and cardiac magnetic resonance (CMR) are used for detection of CS. The relative diagnostic value of these has not been well studied. The aim was to compare these imaging modalities in this population. METHODS: We recruited steroid-naive patients with newly diagnosed CSD due to CS. All CS patients underwent both imaging studies within 12 weeks of each other...
February 2016: European Journal of Nuclear Medicine and Molecular Imaging
Louise Mc Grath-Lone, Sophie Day, Claudia Schoenborn, Helen Ward
BACKGROUND: Inequalities in cancer research participation are thought to exist with certain groups under-represented in research populations; however, much of the evidence is based on small-scale studies. The aim of this study was to explore data from in-depth interviews with cancer patients and a large national survey to investigate variation in who is asked to participate in research and who takes part. METHODS: Factors associated with research discussion and participation were explored in National Cancer Patient Experience Survey data using multivariate logistic regression and during in-depth interviews with 25 breast cancer patients...
2015: BMC Cancer
Lindsay J DiStefano, Jessica C Martinez, Elizabeth Crowley, Erin Matteau, Michael S Kerner, Michelle C Boling, Anh-Dung Nguyen, Thomas H Trojian
Understanding how neuromuscular factors that are associated with lower extremity injury risk, such as landing kinematics, muscle strength, and flexibility, change as children mature may enhance age-specific recommendations for injury prevention programs. The purpose of this study was to compare these factors in prepubertal, pubertal, and postpubertal male and female athletes. Subjects were classified on maturation stage (prepubertal: 16 males, 15 females, age: 9 ± 1 years; pubertal: 13 males, 12 females, age: 12 ± 3 years; postpubertal: 30 males, 27 females, age: 16 ± 2 years)...
September 2015: Journal of Strength and Conditioning Research
Emeline L Maillet, Nicolas Milon, Mari D Heghinian, James Fishback, Stephan C Schürer, Nandor Garamszegi, Deborah C Mash
Noribogaine is the long-lived human metabolite of the anti-addictive substance ibogaine. Noribogaine efficaciously reaches the brain with concentrations up to 20 μM after acute therapeutic dose of 40 mg/kg ibogaine in animals. Noribogaine displays atypical opioid-like components in vivo, anti-addictive effects and potent modulatory properties of the tolerance to opiates for which the mode of action remained uncharacterized thus far. Our binding experiments and computational simulations indicate that noribogaine may bind to the orthosteric morphinan binding site of the opioid receptors...
December 2015: Neuropharmacology
Alia Ben Ghacham, Emmanuelle Cecchi, Louis-César Pasquier, Jean-François Blais, Guy Mercier
Mineral carbonation (MC) represents a promising alternative for sequestering CO2. In this work, the CO2 sequestration capacity of the available calcium-bearing materials waste concrete and anorthosite tailings is assessed in gas-solid-liquid and gas-solid routes using 18.2% flue CO2 gas. The objective is to screen for a better potential residue and phase route and as the ultimate purpose to develop a cost-effective process. The results indicate the possibility of removing 66% from inlet CO2 using waste concrete for the aqueous route...
November 1, 2015: Journal of Environmental Management
Tomomi Nakamura, Taku Tsuburai, Aya Tokinaga, Izumi Nakajima, Reiko Kitayama, Yuichi Imai, Tomoko Nagata, Hiroshi Yoshida, Fumiki Hirahara, Hideya Sakakibara
Estrogen replacement therapy (ERT) is necessary for uterine development and bone mass acquisition in women with Turner syndrome (TS) suffering from ovarian insufficiency. However, adequate ERT regimens have not yet been established. The aim of this study was to evaluate the efficacy of ERT for both uterine development and bone mass acquisition. One hundred TS patients from Yokohama City University Hospital (88 with primary amenorrhea (PA) and 12 patients with spontaneous menstrual cycles (MC)) were enrolled after obtaining consent...
2015: Endocrine Journal
G Kelly, R Hughes, T McGarry, M van den Born, K Adamzik, R Fitzgerald, C Lawlor, A M Tobin, C M Sweeney, B Kirby
BACKGROUND: There is a dearth of information on the precise pathogenesis of hidradenitis suppurativa (HS), but immune dysregulation is implicated. OBJECTIVES: To determine the nature of the immune response in HS. METHODS: Skin biopsies - lesional, perilesional (2 cm away) and uninvolved (10 cm away) - were obtained from patients with HS and healthy controls. The expression of various cytokines was determined by enzyme-linked immunosorbent assay, flow cytometry and real-time polymerase chain reaction...
December 2015: British Journal of Dermatology
Mariano Matteo Lanna, Dario Consonni, Stefano Faiola, Vito Schena, Martina Ratti, Enrico Ferrazzi, Maria Angela Rustico
INTRODUCTION: Vascular anastomoses in monochorionic (MC) twin placenta can be easily identified with color-dye injection. The aim of this study is to analyze the relationship between different type of anastomoses and twin pregnancy complications. METHODS: From January 2011 to October 2014, MC placentas were analyzed with color-dye injection and five group of pregnancies were identified: those that were not complicated (NC), those complicated with selective intrauterine growth restriction (sIUGR), twin-twin transfusion syndrome (TTTS), or twin anemia-polycitemia sequence (TAPS) and those with amniotic fluid discordance (AFD) between twins...
October 2015: Placenta
Noah D Shaftel, Omri Ayalon, Shian Liu, Anthony Sapienza, Steven Green
PURPOSE: A 2-part biomechanical study was constructed to test the hypothesis that coronal morphology of the thumb metacarpophalangeal joint impacts the assessment of instability in the context of radial collateral ligament (RCL) injury. METHODS: Fourteen cadaveric thumbs were disarticulated at the carpometacarpal joint. Four observers measured the radius of curvature of the metacarpal (MC) heads. In a custom jig, a micrometer was used to measure the RCL length as each thumb was put through a flexion and/or extension arc under a 200 g ulnar deviation load...
September 2015: Journal of Hand Surgery
Karolina Kaczmarczyk, Jacek Musiał, Jerzy Soja, Marek Kuźniewski, Agnieszka Gala-Błądzińska, Magdalena Białas, Krzysztof Okoń
Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus; in LN class IV morphologic lesions may be similar to the lesions in primary membranoproliferative glomerulonephritis (MPGN). The aim of the study was to compare the counts of tryptase-positive and chymase-positive mast cells between LN class IV and MPGN. The material consisted of 61 renal biopsies: 32 with lupus nephritis class IV, and 29 with membranoproliferative glomerulonephritis. Chymase- and tryptase-positive cells were stained by immunohistochemistry and subsequently counted...
June 2015: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
Shingo Nishiyama, Hiroyuki Ohba, Masakatsu Kanazawa, Takeharu Kakiuchi, Hideo Tsukada
This study was aimed to assess the correlations among α7 nicotinic acetylcholine receptor (α7-nAChR) binding, amyloid-β (Aβ) deposition, and mitochondrial complex I (MC-I) activity in the brain of aged monkeys (Macaca mulatta). Positron emission tomography (PET) measurements with [(11) C](R)-MeQAA, [(11) C]PIB, and [(18) F]BCPP-EF were conducted in monkeys in a conscious condition. [(11) C](R)-MeQAA binding was analyzed by a simplified reference tissue model to calculate nondisplaceable binding potential (BPND), [(11) C]PIB uptake was calculated by standard uptake value ratio (SUVR), and [(18) F]BCPP-EF binding was determined by Logan graphical analysis to calculate total distribution volume (VT) with arterial blood sampling...
October 2015: Synapse
J J Vaux, R R Hugate, J W Hills, R F Grzybowski, C K Funk
INTRODUCTION: Amputation of the thumb presents a serious insult to the hand and diminished quality of life for a patient physically, vocationally, and possibly psychologically. The aim of this study was to define the geometry of the thumb metacarpal in order to help create a standardized set of transcutaneous osseointegrated prostheses to treat patients who have suffered amputation of the thumb at the level of the metacarpophalangeal joint. MATERIALS AND METHODS: A total of 80 metacarpals from 46 cadavers were studied...
January 2016: Surgical and Radiologic Anatomy: SRA
Sharief Hendricks, Sam O'connor, Michael Lambert, James Brown, Nicholas Burger, Sarah Mc Fie, Clint Readhead, Wayne Viljoen
In rugby union, understanding the techniques and events leading to concussions is important because of the nature of the injury and the severity and potential long-term consequences, particularly in junior players. Proper contact technique is a prerequisite for successful participation in rugby and is a major factor associated with injury. However, the execution of proper contact technique and its relationship to injury has yet to be studied in matches. Therefore, the aim of this study was to compare contact techniques leading to concussion with a representative sample of similarly matched non-injury (NI) contact events...
2015: European Journal of Sport Science
Masaki Naka, Yoshihiro Ohishi, Tsunehisa Kaku, Sumiko Watanabe, Sadafumi Tamiya, Fumihiko Ookubo, Kiyoko Kato, Yoshinao Oda, Setsuo Sugishima
OBJECTIVE: The aim of this study was to clarify the diagnostic significance of the presence of intranuclear inclusions in clear cell carcinoma (CCC). MATERIALS AND METHODS: We analyzed 98 imprint specimens and 53 ascites specimens from 98 ovarian carcinoma cases [28 CCCs, 37 serous carcinomas (SCs), 22 endometrioid carcinomas (ECs), and 11 mucinous carcinomas (MCs)]. We examined (1) frequency of intranuclear inclusion-positive cases of each ovarian carcinoma subtype, using imprint specimens, (2) frequency of intranuclear inclusion-positive cells of each ovarian carcinoma subtype, using imprint specimens, (3) frequency of intranuclear inclusion-positive cases of each ovarian carcinoma subtype, using ascites specimens, and (4) sensitivity and specificity of the presence of intranuclear inclusions for the cytological diagnosis of CCC...
November 2015: Diagnostic Cytopathology
Darta Klavina, Taina Pennanen, Talis Gaitnieks, Sannakajsa Velmala, Andis Lazdins, Dagnija Lazdina, Audrius Menkis
We studied long-term effects of fertilization with wood ash on biomass, vitality and mycorrhizal colonization of fine roots in three conifer forest stands growing in Vacciniosa turf. mel. (V), Myrtillosa turf. mel. (M) and Myrtillosa turf. mel./Caricoso-phragmitosa (MC) forest types on peat soils. Fertilization trials amounting 5 kg/m(2) of wood ash were established 12 years prior to this study. A total of 63 soil samples with roots were collected and analysed. Ectomycorrhizal (ECM) fungi in roots were identified by morphotyping and sequencing of the fungal internal transcribed spacer (ITS) region...
February 2016: Mycorrhiza
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