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Fatigue and apathy

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https://www.readbyqxmd.com/read/29447582/clinical-characteristics-and-quality-of-life-in-chinese-patients-with-parkinson-s-disease-beyond-20-years
#1
Ruwei Ou, Yanbing Hou, Wei Song, Qianqian Wei, Yongping Chen, Bei Cao, Xiaoqin Yuan, Huifang Shang
Background The number of Parkinson's disease (PD) patients with disease duration of more than 20 years (long disease duration PD, LPD) is on the rise. Objectives This study aims to describe the clinical profiles and the quality of life (QoL) of LPD patients from a cohort of the Chinese population. Methods We compared 71 LPD subjects to 60 PD patients who died less than 20 years after the onset of PD (control PD, CPD). A regression model was constructed to assess the determinants for 20 years survival and the QoL of LPD patients...
February 15, 2018: Neurological Research
https://www.readbyqxmd.com/read/29400690/the-impact-of-visible-and-invisible-symptoms-on-employment-status-work-and-social-functioning-in-multiple-sclerosis
#2
L Lorefice, G Fenu, J Frau, G C Coghe, M G Marrosu, E Cocco
BACKGROUND: Frequently diagnosed in young adulthood, multiple sclerosis (MS) and several MS-related factors can influence patients' unemployment status and negatively affect work productivity and daily functioning. OBJECTIVE: We examined MS patients' employment status and evaluated clinical features influencing it. Furthermore, we investigated patients' burdens due to visible and invisible MS symptoms through their worsening daily functioning. METHODS: The study included outpatients affected by MS according to the 2010 McDonald criteria...
January 31, 2018: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29365361/enteral-access-devices-types-function-care-and-challenges
#3
REVIEW
Linda M Lord
Enteral access feeding devices are placed in patients who have a functional and accessible gastrointestinal (GI) tract but are not able to consume or absorb enough nutrients to sustain adequate nutrition and hydration. For many individuals, enteral nutrition support is a lifesaving modality to prevent or treat a depleted nutrient state that can lead to tissue breakdown, compromised immune function, and poor wound healing. Psychological well-being is also affected with malnutrition and dehydration, triggering feelings of apathy, depression, fatigue, and loss of morale, negatively impacting a patient's ability for self-care...
February 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29330419/parkinson-disease-with-constipation-clinical-features-and-relevant-factors
#4
Qiu-Jin Yu, Shu-Yang Yu, Li-Jun Zuo, Teng-Hong Lian, Yang Hu, Rui-Dan Wang, Ying-Shan Piao, Peng Guo, Li Liu, Zhao Jin, Li-Xia Li, Piu Chan, Sheng-Di Chen, Xiao-Min Wang, Wei Zhang
Constipation is one of the most frequent non-motor symptoms of Parkinson disease (PD) and it may be ignored by PD patients, leading to this problem not to be reported in time. The relationships between constipation and demographic variables, motor symptoms and other non-motor symptoms of PD are still unknown. PD patients were evaluated by diagnostic criteria of functional constipation in Rome III and divided into PD with constipation (PD-C) and PD with no constipation (PD-NC) groups. PD patients were assessed by rating scales of motor symptoms and other non-motor symptoms, activity of daily living and quality of life...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29304202/-i-feel-worn-out-as-if-i-neglected-myself-older-patients-perspectives-on-post-hospital-symptoms-after-acute-hospitalization
#5
Rosanne van Seben, Lucienne A Reichardt, Dirk R Essink, Barbara C van Munster, Jos A Bosch, Bianca M Buurman
Background: The transition between hospital and home is a vulnerable period for acutely hospitalized older patients during which they are at increased risk for adverse health outcomes. Yet, studies describing experiences of a geriatric patient population postdischarge from a patient perspective are missing. Objective: To characterize patient experiences with recovering at home after acute hospitalization. Design and Methods: Qualitative semi-structured interviews, involving 20 recently discharged patients (age ≥ 70), were conducted...
January 3, 2018: Gerontologist
https://www.readbyqxmd.com/read/29238748/non-motor-symptoms-in-progressive-supranuclear-palsy-prevalence-and-severity
#6
Fabiana Giada Radicati, Pablo Martinez Martin, Chiara Fossati, Kallol Ray Chaudhuri, Margherita Torti, Carmen Rodriguez Blazquez, Laura Vacca, Fabrizio Stocchi
NMSs have been extensively studied in PD patients but not in other forms of parkinsonism such as Progressive Supranuclear Palsy (PSP). The primary objective of this study was to analyze the frequency, severity and the type of non-motor symptoms (NMS) in PSP patients using the non-motor symptoms scale (NMSS). The secondary objective was to differentiate NMS between PSP and Parkinson's disease (PD). We enrolled in this cross-sectional study 50 consecutive PSP and 100 matched Parkinson's disease (PD) patients, in the proportion PSP/PD = 1/2, matched in age, sex, and disease duration...
2017: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/29238389/the-role-of-physical-activity-on-mood-state-and-functional-skills-of-elderly-women
#7
Renato Sobral Monteiro-Junior, Vinicius Dias Rodrigues, Carlos Campos, Flávia Paes, Eric Murillo-Rodriguez, Geraldo A Maranhão-Neto, Sergio Machado
Introduction: Ageing is associated with several physical, psychological and behavioral changes. These changes are closely related with global health and functional capacity in the elderly. Mood disturbances are common among the elderly and may significantly increase apathy, resulting in decreased habitual physical activity levels. Materials and Methods: The purpose of this cross-sectional study was to evaluate the mood state and functional motor capacities of elderly women engaged in a public physical activity program in Brazil and compare them with physically inactive elderly...
2017: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/29193182/cognitive-impairment-and-quality-of-life-in-patients-with-myotonic-dystrophy-type-1
#8
Haruo Fujino, Honoka Shingaki, Shugo Suwazono, Yukihiko Ueda, Chizu Wada, Takahiro Nakayama, Masanori P Takahashi, Osamu Imura, Tsuyoshi Matsumura
INTRODUCTION: This study sought to clarify whether specific cognitive abilities are impaired in patients with myotonic dystrophy type 1 (DM1) as well as to investigate the relationships among quality of life (QoL), cognitive function, and psychological factors. METHODS: Sixty patients with DM1 were evaluated on cognitive functioning (abstract reasoning, attention/working memory, executive function, processing speed, and visuoconstructive ability), apathy, depression, excessive daytime sleepiness, fatigue, and QoL...
November 28, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29186356/altered-caudate-connectivity-is-associated-with-executive-dysfunction-after-traumatic-brain-injury
#9
Sara De Simoni, Peter O Jenkins, Niall J Bourke, Jessica J Fleminger, Peter J Hellyer, Amy E Jolly, Maneesh C Patel, James H Cole, Robert Leech, David J Sharp
Traumatic brain injury often produces executive dysfunction. This characteristic cognitive impairment often causes long-term problems with behaviour and personality. Frontal lobe injuries are associated with executive dysfunction, but it is unclear how these injuries relate to corticostriatal interactions that are known to play an important role in behavioural control. We hypothesized that executive dysfunction after traumatic brain injury would be associated with abnormal corticostriatal interactions, a question that has not previously been investigated...
November 23, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29073590/temporal-associations-between-fatigue-depression-and-apathy-after-stroke-results-of-the-cognition-and-affect-after-stroke-a-prospective-evaluation-of-risks-study
#10
Elles Douven, Sebastian Köhler, Syenna H J Schievink, Robert J van Oostenbrugge, Julie Staals, Frans R J Verhey, Pauline Aalten
BACKGROUND: Poststroke fatigue (PSF) is a form of pathological fatigue that can develop after stroke and has a negative impact on functional outcome. PSF is associated with poststroke depression (PSD), which in turn shows similarities with poststroke apathy (PSA). This study aimed at disentangling the temporal associations between PSF and PSD and between PSF and PSA. METHODS: A total of 250 stroke patients were included, of which 243 completed the Fatigue Severity Scale, Montgomery-Åsberg Depression Rating Scale, and Apathy Evaluation Scale at 3 months poststroke, with follow-up measurements at 6 and 12 months after initial testing...
October 26, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29037500/motor-behavioural-and-cognitive-correlates-of-fatigue-in-early-de-novo-parkinson-disease-patients
#11
M Siciliano, L Trojano, R De Micco, A De Mase, F Garramone, A Russo, G Tedeschi, A Tessitore
INTRODUCTION: Fatigue is one of the most common and disabling non-motor symptoms in Parkinson's disease (PD). The objective of this study was to determine prevalence and motor, behavioural, and cognitive correlates of distressing fatigue in early, de novo PD patients. METHODS: Eighty-one consecutive de novo PD patients (64% men; mean age 65.73 ± 8.26 years) underwent a comprehensive examination, including Parkinson's disease Fatigue Scale (PFS), Epworth Sleepiness Scale (ESS), Parkinson's Disease Sleep Scale (PDSS), Beck Depression Inventory (BDI), Parkinson's Anxiety Scale (PAS), and Apathy Evaluation Scale (AES)...
October 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28990169/methylphenidate-cognition-and-epilepsy-a-1-month-open-label-trial
#12
Jesse Adams, Valerie Alipio-Jocson, Katherine Inoyama, Victoria Bartlett, Saira Sandhu, Jemima Oso, John J Barry, David W Loring, Kimford J Meador
OBJECTIVE: Cognitive difficulties are common in epilepsy. Beyond reducing seizures and adjusting antiepileptic medications, no well-validated treatment exists in adults. Methylphenidate is used effectively in children with epilepsy and attention-deficit/hyperactivity disorder, but its effects in adults have not been systematically evaluated. We hypothesized that methylphenidate can safely improve cognition in adults with epilepsy. We detail here the open-label follow-up to a double-blind, placebo-controlled, single-dose study...
October 9, 2017: Epilepsia
https://www.readbyqxmd.com/read/28980577/-depression-and-depression-related-disorders-after-a-subarachnoid-hemorrhage
#13
M A Kutlubaev, L R Akhmadeeva
Psychiatric disorders often develop after subarachnoid hemorrhage (SAH); the most frequent of them are depression and depression-related disorders (anxiety, apathy, pathological fatigue, posttraumatic stress disorder, etc.). Both biological and psychological mechanisms may underlie the development of these disorders. Depression and depression-related disorders decrease patients' quality of life and prevent the full recovery after SAH. Identification and correction of these disorders should take a prominent place in the rehabilitation of post-SAH patients...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28947882/the-problem-of-fatigue-in-patients-suffering-from-neoplastic-disease
#14
REVIEW
Agnieszka Kolak, Marzena Kamińska, Elwira Wysokińska, Dariusz Surdyka, Dariusz Kieszko, Magdalena Pakieła, Franciszek Burdan
Modern therapeutic management of patients with cancer is associated with many adverse side effects, including fatigue defined as weariness, burnout, lassitude, malaise, apathy, impatience, and/or inability to perform daily activities. It occurs frequently before the diagnosis of cancer and may persist for a long time after the end of cancer therapy. It is a common problem that occurs regardless of the type of cancer and applied therapeutic procedure. The appearance of this symptom significantly affects the quality of life of patients and often reduces the effectiveness of implemented treatment...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28918694/brain-metabolic-correlates-of-fatigue-in-parkinson-s-disease-a-pet-study
#15
Li Zhang, Tiannv Li, Yongsheng Yuan, Qing Tong, Siming Jiang, Min Wang, Jianwei Wang, Jian Ding, Qinrong Xu, Kezhong Zhang
The neural bases of fatigue in Parkinson's disease (PD) remain uncertain. We aimed to assess the brain metabolic correlates of fatigue in patients with PD. Twenty-seven PD patients without clinically relevant depression (17-item Hamilton Depression Rating Scale [HAMD] score ≥ 14), apathy (Apathy Scale [AS] score ≥ 14) and excessive daytime somnolence (Epworth Sleepiness Scale [ESS] score ≥ 10) were evaluated with Fatigue Severity Scale (FSS). Each patient had an F-18 fluorodeoxyglucose PET (FDG-PET) scan...
September 18, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28874701/restless-legs-syndrome-in-parkinson-disease-clinical-characteristics-abnormal-iron-metabolism-and-altered-neurotransmitters
#16
Ying-Shan Piao, Teng-Hong Lian, Yang Hu, Li-Jun Zuo, Peng Guo, Shu-Yang Yu, Li Liu, Zhao Jin, Hui Zhao, Li-Xia Li, Qiu-Jin Yu, Rui-Dan Wang, Sheng-Di Chen, Piu Chan, Xiao-Min Wang, Wei Zhang
Relationships among clinical characteristics, iron metabolism and neurotransmitters in Parkinson disease (PD) patients with restless legs syndrome (RLS) remains unclear. We divided 218 patients into PD with and with no RLS (PD-RLS and PD-NRLS) groups by RLS-rating scale (RLS-RS) score. Motor and non-motor symptoms were rated by related scales. Iron and related proteins, and neurotransmitters in cerebrospinal fluid (CSF) and serum were measured. PD-RLS frequency was 40.37%. PD-RLS group had longer duration, higher stage and scores of motor symptoms, depression, anxiety, sleep disorders, fatigue and apathy, and increased transferrin and decreased iron, ferritin, dopamine (DA) and 5-hydroxytryptamine (5-HT) in CSF...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28844367/apathy-in-drug-na%C3%A3-ve-patients-with-parkinson-s-disease
#17
Hui Liu, Ruwei Ou, Qianqian Wei, Yanbing Hou, Lingyu Zhang, Bei Cao, Bi Zhao, Wei Song, Huifang Shang
OBJECTIVE: The aim of this study is to explore the prevalence and clinical correlates of apathy in early-stage Parkinson's disease (PD) from a cohort of Chinese patients. METHODS: A cross-sectional analysis of 133 treatment-naive PD patients was conducted. Each subject was categorized as PD with or without apathy using the Lille Apathy Rating Scale (LARS). RESULTS: Of 133 patients, 30 PD patients (22.56%) reported apathy, of whom 23 (17.29%) did not have concomitant depression...
August 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28805568/complementary-and-alternative-medicine-and-exercise-in-nonmotor-symptoms-of-parkinson-s-disease
#18
Indu Subramanian
The use of complementary and alternative medicine (CAM) therapy in nonmotor symptoms (NMS) for Parkinson disease (PD) is growing worldwide. Well-performed, systematic evidence-based research is largely lacking in this area and many studies include various forms of CAM with small patient numbers and a lack of standardization of the approaches studied. Taichi, Qigong, dance, yoga, mindfulness, acupuncture, and other CAM therapies are reviewed and there is some evidence for the following: Taichi in sleep and PDQ39; dance in cognition, apathy, and a mild trend to improved fatigue; yoga in PDQ39; and acupuncture in depression, PDQ39, and sleep...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28803229/non-motor-symptoms-assessed-by-non-motor-symptoms-questionnaire-and-non-motor-symptoms-scale-in-parkinson-s-disease-in-selected-asian-populations
#19
Anna Sauerbier, Onanong Jitkritsadakul, Nataliya Titova, Lisa Klingelhoefer, Yoshio Tsuboi, Harry Carr, Hrishikesh Kumar, Rebecca Banerjee, Roberto Erro, Roongroj Bhidayasiri, Anette Schrag, Panagiotis Zis, Shen-Yang Lim, J Y Al-Hashel, Walaa A Kamel, Pablo Martinez-Martin, K Ray Chaudhuri
BACKGROUND: Ethnic variations have been described in medical conditions, such as hypertension, diabetes, and multiple sclerosis. Whether ethnicity plays a role in Parkinson's disease (PD), particularly with regard to non-motor symptoms (NMS), remains unclear. Existing literature is diverse, controversial, and inadequately documented. This review aims to analyse and report the currently available literature on NMS, specifically in Asian PD patients. SUMMARY: We conducted a literature review using PubMed, searching for articles and currently available publications that reference and assess NMS in PD patients living in Asia using the validated NMS Questionnaire (NMS Quest) and NMS Scale (NMSS)...
2017: Neuroepidemiology
https://www.readbyqxmd.com/read/28721049/the-potential-role-of-vagus-nerve-stimulation-in-the-treatment-of-hiv-associated-depression-a-review-of-literature
#20
REVIEW
William C Nicholson, Mirjam-Colette Kempf, Linda Moneyham, David E Vance
Depression is the most common comorbidity and neuropsychiatric complication in HIV. Estimates suggest that the prevalence rate for depression among HIV-infected individuals is three times that of the general population. The association between HIV and clinical depression is complex; however, chronic activation of inflammatory mechanisms, which disrupt central nervous system (CNS) function, may contribute to this association. Disruptions in CNS function can result in cognitive disorders, social withdrawal, fatigue, apathy, psychomotor impairment, and sleep disturbances, which are common manifestations in depression and HIV alike...
2017: Neuropsychiatric Disease and Treatment
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