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Fatigue and apathy

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https://www.readbyqxmd.com/read/28246572/impact-of-combined-subthalamic-nucleus-and-substantia-nigra-stimulation-on-neuropsychiatric-symptoms-in-parkinson-s-disease-patients
#1
U Hidding, A Gulberti, A Horn, C Buhmann, W Hamel, J A Koeppen, M Westphal, A K Engel, C Gerloff, D Weiss, C K E Moll, M Pötter-Nerger
The goal of the study was to compare the tolerability and the effects of conventional subthalamic nucleus (STN) and combined subthalamic nucleus and substantia nigra (STN+SNr) high-frequency stimulation in regard to neuropsychiatric symptoms in Parkinson's disease patients. In this single center, randomized, double-blind, cross-over clinical trial, twelve patients with advanced Parkinson's disease (1 female; age: 61.3 ± 7.3 years; disease duration: 12.3 ± 5.4 years; Hoehn and Yahr stage: 2.2 ± 0.39) were included...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28228566/reduced-cognitive-function-in-patients-with-parkinson-disease-and-obstructive-sleep-apnea
#2
Victoria P Mery, Priti Gros, Anne-Louise Lafontaine, Ann Robinson, Andrea Benedetti, R John Kimoff, Marta Kaminska
OBJECTIVE: To assess the association between obstructive sleep apnea (OSA) and nonmotor symptoms (NMS), including cognitive dysfunction, in patients with Parkinson disease (PD). METHODS: Patients with idiopathic PD, recruited from a movement disorder clinic, underwent overnight polysomnography. OSA was defined as an apnea-hypopnea index (AHI) ≥15/h. PD severity was assessed using the Hoehn & Yahr (H&Y) scale and the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS)...
February 22, 2017: Neurology
https://www.readbyqxmd.com/read/28202373/is-fatigue-associated-with-cognitive-dysfunction-in-early-parkinson-s-disease
#3
Benzi M Kluger, Kenn Freddy Pedersen, Ole-Bjorn Tysnes, Solgunn O Ongre, Bjørg Øygarden, Karen Herlofson
INTRODUCTION: Fatigue is a common and disabling symptom which may be seen in early Parkinson's disease (PD). Our understanding of the phenomenology and etiology of fatigue in PD is limited. The objective of this study was to determine whether fatigue was related to cognition in early PD patients. METHODS: The study is part of the Norwegian ParkWest project, a population-based cohort study, comprising 184 de novo, drug-naïve patients with PD. PD was diagnosed according to the Gelb criteria...
February 7, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28156461/utilizing-electronic-technologies-to-measure-patient-reported-outcomes-pro-assessment-completion-time
#4
Tony Lam, Marsha N Richardson, Ellen F Manzullo, Michael Kallen, DerShung Yang, Niina Mari Haas, Carmelita P Escalante
69 Background: Patient-reported outcomes (PROs) contribute to the assessment and treatment of cancer-related fatigue (CRF). Paper-based symptom assessments are cumbersome and time-consuming. Electronic assessments are an efficient alternative. This study describes CRF Clinic patients at a major cancer Institution, the time they required to complete self-reported CRF symptom assessments via a tablet computer (iPad), and the factors influencing PRO assessment completion time. METHODS: From 1/1/2011 to 8/21/2012, 190 newly-referred CRF Clinic patients utilized an iPad to complete standardized CRF symptom assessments for: fatigue, pain, depression, anxiety, stress, sleepiness, and apathy...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28089250/pathology-of-behavior-in-pd-what-is-known-and-what-is-not
#5
REVIEW
Kaylena A Ehgoetz Martens, Simon J G Lewis
Abnormal behavior in Parkinson's disease (PD) stems from a complex orchestration of impaired neural networks that result from PD-related neurodegeneration across multiple levels. Typically, cellular and tissue abnormalities generate neurochemical changes and disrupt specific regions of the brain, in turn creating impaired neural circuits and dysfunctional global networks. The objective of this chapter is to provide an overview of the array of pathological changes that have been linked to different behavioral symptoms of PD such as depression, anxiety, apathy, fatigue, impulse control disorders, psychosis, sleep disorders and dementia...
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28076387/distinct-subtypes-of-apathy-revealed-by-the-apathy-motivation-index
#6
Yuen-Siang Ang, Patricia Lockwood, Matthew A J Apps, Kinan Muhammed, Masud Husain
Apathy is a debilitating but poorly understood disorder characterized by a reduction in motivation. As well as being associated with several brain disorders, apathy is also prevalent in varying degrees in healthy people. Whilst many tools have been developed to assess levels of apathy in clinical disorders, surprisingly there are no measures of apathy suitable for healthy people. Moreover, although apathy is commonly comorbid with symptoms of depression, anhedonia and fatigue, how and why these symptoms are associated is unclear...
2017: PloS One
https://www.readbyqxmd.com/read/27993522/non-motor-symptoms-and-the-quality-of-life-in-multiple-system-atrophy-with-different-subtypes
#7
LingYu Zhang, Bei Cao, RuWei Ou, Qian-Qian Wei, Bi Zhao, Jing Yang, Ying Wu, HuiFang Shang
BACKGROUND: The differences in non-motor symptoms (NMS) and quality of life (QOL) between MSA patients with different subtypes remain unknown, so do the determinants of poor QOL in both subtypes. METHODS: A total of 172 MSA patients were enrolled in the study. NMS of patients with MSA were assessed using the non-motor symptoms scale (NMSS) and Parkinson's Disease Questionnaire-39 item version (PDQ-39) was used to evaluate the QOL of patients with MSA. RESULTS: The most prevalent NMS domain was urinary (91...
December 13, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27865517/effects-of-melatonin-in-the-treatment-of-asthenia-in-aneurysmal-subarachnoid-hemorrhage
#8
V Gilard, F-X Ferracci, O Langlois, S Derrey, F Proust, S Curey
BACKGROUND AND OBJECTIVES: Survivors of aneurysmal subarachnoid hemorrhage (aSAH) commonly experience sleep disorders resulting in asthenia. The objective of this prospective study was to determine, in a cohort of patients with treated ruptured intracranial aneurysm (IA), the proportion of asthenia at 2months, in a cohort of patients treated with melatonin and in a control cohort. PATIENTS AND METHODS: Twenty consecutive patients admitted for the treatment of ruptured IA and able to answer a standardized questionnaire were included in the study...
December 2016: Neuro-Chirurgie
https://www.readbyqxmd.com/read/27670392/fatigue-in-early-parkinson-s-disease-the-norwegian-parkwest-study
#9
S O Ongre, J P Larsen, O B Tysnes, K Herlofson
BACKGROUND AND PURPOSE: Fatigue is a common and disabling non-motor symptom in Parkinson's disease (PD). The pathogenesis is unknown, and the treatment options are limited. The aim of the present study was to investigate the development of fatigue during the first year after diagnosis. METHODS: The study design was a prospective, controlled population-based longitudinal cohort study, comprising 181 de novo, drug-naïve patients with PD and 162 control participants...
January 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27600158/an-objective-measure-combining-physical-and-cognitive-fatigability-correlation-with-subjective-fatigue-in-parkinson-s-disease
#10
Davide Martino, Tiziano Tamburini, Panagiotis Zis, Gavril Rosoklija, Giovanni Abbruzzese, Kallol Ray-Chaudhuri, Elisa Pelosin, Laura Avanzino
BACKGROUND: Objective measures of physical and cognitive fatigability do not correlate with subjective Parkinson's disease (PD)-related fatigue. The relationship of subjective PD-related fatigue to tasks combining cognitive and motor effort has never been explored. METHODS: Forty-four right-handed, non-demented PD patients, 22 with (PD-F) and 22 without (PD-NF) fatigue, were tested using a sensor-engineered glove on their more affected hand. Patients performed sequential opposition finger movements following a metronome at 2 Hz for 5 min (cued task), and for another minute following a 2-min rest...
August 31, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27583249/the-impact-of-physical-activity-on-non-motor-symptoms-in-parkinson-s-disease-a-systematic-review
#11
REVIEW
Melanie E Cusso, Kenneth J Donald, Tien K Khoo
Parkinson's disease (PD) is a neurological disorder that is associated with both motor and non-motor symptoms (NMS). The management of PD is primarily via pharmaceutical treatment; however, non-pharmaceutical interventions have become increasingly recognized in the management of motor and NMS. In this review, the efficacy of physical activity, including physiotherapy and occupational therapy, as an intervention in NMS will be assessed. The papers were extracted between the 20th and 22nd of June 2016 from PubMed, Web of Science, Medline, Ovid, SportsDiscuss, and Scopus using the MeSH search terms "Parkinson's," "Parkinson," and "Parkinsonism" in conjunction with "exercise," "physical activity," "physiotherapy," "occupational therapy," "physical therapy," "rehabilitation," "dance," and "martial arts...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27573215/non-motor-symptoms-in-portuguese-parkinson-s-disease-patients-correlation-and-impact-on-quality-of-life-and-activities-of-daily-living
#12
Paulo Bugalho, Tânia Lampreia, Rita Miguel, Marcelo D Mendonça, André Caetano, Raquel Barbosa
The prevalence of non-motor symptoms (NMS) in Parkinson's Disease (PD) has varied between studies. Their interrelation isn't totally understood. Also, the relative importance of each symptom, regarding its impact on activities of daily living (ADL) and health related quality of life (HRQL), remains debatable. We assessed all PD patients attending a Portuguese tertiary movement disorders center during one year (n = 134), with ADL, HRQL and other clinical scales approved for identifying the most relevant NMS in PD...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27448517/apathy-in-multiple-sclerosis-gender-matters
#13
Ana M Novo, Sonia Batista, Joana Tenente, Carla Nunes, Carmo Macário, Lívia Sousa, Freire Gonçalves
Apathy has been recognized as a frequent symptom in multiple sclerosis (MS) but uncertainty remains about its prevalence and clinical correlates. Therefore, the objective of this work was to assess the prevalence of apathy in patients with MS and to identify clinical and demographic correlates. A case-control study with 30 patients and 30 healthy controls matched for age, gender and education was performed. Apathy diagnosis was established using Robert et al.'s criteria. Additionally, apathy was assessed using the 10-item short version of the clinical-rated Apathy Evaluation Scale (AES-C-10)...
November 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27366343/pathophysiology-of-motor-dysfunction-in-parkinson-s-disease-as-the-rationale-for-drug-treatment-and-rehabilitation
#14
REVIEW
Francesca Magrinelli, Alessandro Picelli, Pierluigi Tocco, Angela Federico, Laura Roncari, Nicola Smania, Giampietro Zanette, Stefano Tamburin
Cardinal motor features of Parkinson's disease (PD) include bradykinesia, rest tremor, and rigidity, which appear in the early stages of the disease and largely depend on dopaminergic nigrostriatal denervation. Intermediate and advanced PD stages are characterized by motor fluctuations and dyskinesia, which depend on complex mechanisms secondary to severe nigrostriatal loss and to the problems related to oral levodopa absorption, and motor and nonmotor symptoms and signs that are secondary to marked dopaminergic loss and multisystem neurodegeneration with damage to nondopaminergic pathways...
2016: Parkinson's Disease
https://www.readbyqxmd.com/read/27366342/characteristics-of-nonmotor-symptoms-in-progressive-supranuclear-palsy
#15
Ruwei Ou, Wei Song, Qianqian Wei, Ke Chen, Bei Cao, Yanbing Hou, Bi Zhao, Huifang Shang
Objectives. To explore the clinical correlates of nonmotor symptoms (NMS) in progressive supranuclear palsy (PSP) and their differences from healthy controls and patients with Parkinson's disease (PD). Methods. Twenty-seven PSP patients, 27 age- and gender-matched healthy controls (HC), and 27 age- and gender-matched PD patients were included for this case-control study. NMS were assessed using the Nonmotor Symptoms Scale (NMSS, including 9 domains). Results. All PSP patients reported NMS. The frequency and severity of "sleep/fatigue," "mood/apathy," "attention/memory," "gastrointestinal," "sexual dysfunction," and "miscellaneous" domains in PSP group were significantly higher than those in HC group (P < 0...
2016: Parkinson's Disease
https://www.readbyqxmd.com/read/27343346/use-of-the-world-health-organization-quality-of-life-assessment-short-version-in-mild-to-moderate-parkinson-disease
#16
Sarah K Hendred, Erin R Foster
OBJECTIVE: To investigate the distribution, internal consistency reliability, and convergent and discriminant validity of the World Health Organization Quality of Life Scale Brief Version (WHOQOL-BREF) in persons with mild to moderate Parkinson disease (PD). DESIGN: Cross-sectional. SETTING: Movement disorders center. PARTICIPANTS: Convenience sample of people with PD (n=96) recruited from a movement disorders center and controls (n=60) recruited from the community (N=156)...
December 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27335396/computational-dissection-of-dopamine-motor-and-motivational-functions-in-humans
#17
Raphaël Le Bouc, Lionel Rigoux, Liane Schmidt, Bertrand Degos, Marie-Laure Welter, Marie Vidailhet, Jean Daunizeau, Mathias Pessiglione
UNLABELLED: Motor dysfunction (e.g., bradykinesia) and motivational deficit (i.e., apathy) are hallmarks of Parkinson's disease (PD). Yet, it remains unclear whether these two symptoms arise from a same dopaminergic dysfunction. Here, we develop a computational model that articulates motor control to economic decision theory, to dissect the motor and motivational functions of dopamine in humans. This model can capture different aspects of the behavior: choice (which action is selected) and vigor (action speed and intensity)...
June 22, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27092858/correlative-factors-of-cognitive-dysfunction-in-pd-patients-a-cross-sectional-study-from-southwest-china
#18
ShuShan Zhang, RuWei Ou, XuePing Chen, Jing Yang, Bi Zhao, XiaoQin Yuan, QianQian Wei, Bei Cao, Hui-Fang Shang
BACKGROUND: Cognitive dysfunction is common in Parkinson's disease (PD). A comprehensive understanding of cognitive dysfunction and its correlative factors in Chinese PD patients were not available. METHODS: This cross-sectional study included 454 PD patients. Cognitive function was evaluated using the Montreal Cognitive Assessment. Non-motor symptoms were assessed using the Non-Motor Symptoms Scale (NMSS), and depression and anxiety were assessed using the Hamilton Depression Rating Scale and the Hamilton Anxiety Rating Scale, respectively...
May 2016: Neurological Research
https://www.readbyqxmd.com/read/27084227/know-thyself-exploring-interoceptive-sensitivity-in-parkinson-s-disease
#19
Lucia Ricciardi, Gina Ferrazzano, Benedetta Demartini, Francesca Morgante, Roberto Erro, Christos Ganos, Kailash P Bhatia, Alfredo Berardelli, Mark Edwards
BACKGROUND: Although Parkinson's disease (PD) is defined by its motor symptoms, it is now well recognised that cognitive, affective and emotion domains are also impaired. The pathophysiology of these disabling non-motor symptoms (NMS) remains unclear; recently the involvement of limbic areas, including the insula, in the neurodegenerative process has been suggested to have a key role. These areas, and the insula in particular, are also been suggested as key regions for interoception; interoceptive sensitivity (IS) is a measure of the accuracy of perception of sensations from inside the body related to the function of internal organs...
May 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27041545/emotional-manifestations-of-pd-neurobiological-basis
#20
REVIEW
Anna Castrioto, Stéphane Thobois, Sebastien Carnicella, Audrey Maillet, Paul Krack
Neuropsychiatric symptoms are common and disabling in PD. Their neurobiological bases are complex, partly because of the disease itself and partly because of the dopaminergic treatment. The aim of this review is to focus on the emotional manifestations stemming from the neurodegenerative process itself. We focus on depression, anxiety, apathy, and fatigue, which can all be part of the clinical spectrum of premotor disease and may be improved or masked by medications targeting parkinsonian motor signs or psychiatric symptoms as the disease progresses...
August 2016: Movement Disorders: Official Journal of the Movement Disorder Society
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