keyword
MENU ▼
Read by QxMD icon Read
search

Lung clearance index

keyword
https://www.readbyqxmd.com/read/29614238/changes-in-lung-clearance-index-in-preschool-cystic-fibrosis-patients-treated-with-ivacaftor
#1
Felix Ratjen, Michelle Klingel, Philip Black, Michael R Powers, Hartmut Grasemann, Melinda Solomon, Scott D Sagel, Scott H Donaldson, Steven M Rowe, Margaret Rosenfeld
No abstract text is available yet for this article.
April 3, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29582453/bayesian-modelling-of-lung-function-data-from-multiple-breath-washout-tests
#2
Robert K Mahar, John B Carlin, Sarath Ranganathan, Anne-Louise Ponsonby, Peter Vuillermin, Damjan Vukcevic
Paediatric respiratory researchers have widely adopted the multiple-breath washout (MBW) test because it allows assessment of lung function in unsedated infants and is well suited to longitudinal studies of lung development and disease. However, a substantial proportion of MBW tests in infants fail current acceptability criteria. We hypothesised that a model-based approach to analysing the data, in place of traditional simple empirical summaries, would enable more efficient use of these tests. We therefore developed a novel statistical model for infant MBW data and applied it to 1197 tests from 432 individuals from a large birth cohort study...
March 26, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29579539/new-directions-on-lung-clearance-index-variability-and-feasibility
#3
EDITORIAL
Katherine O'Neill, Clare Saunders
No abstract text is available yet for this article.
March 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29573509/multiple-breath-washout-a-new-and-promising-lung-function-test-for-patients-with-idiopathic-pulmonary-fibrosis
#4
Sylvia Nyilas, Theresa Schreder, Florian Singer, Alexander Poellinger, Thomas Kurt Geiser, Philipp Latzin, Manuela Funke
BACKGROUND AND OBJECTIVE: Idiopathic pulmonary fibrosis (IPF) is a devastating progressive lung disease affecting the parenchyma. Nitrogen multiple-breath washout (N2 -MBW) is a lung function test that measures ventilation inhomogeneity, a biomarker of small airway disease. We assessed clinical properties of N2 -MBW in IPF. METHODS: In this prospective cohort pilot study, 25 IPF patients and 25 healthy controls were assessed at baseline and 10 patients at median 6...
March 24, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29497618/leaks-during-multiple-breath-washout-characterisation-and-influence-on-outcomes
#5
Nina Lenherr, Kathryn A Ramsey, Kerstin Jost, Linn Hornwall, Florian Singer, Sophie Yammine, Philipp Latzin
Nitrogen multiple-breath washout (N2 MBW) is increasingly used in patients with cystic fibrosis. The current European Respiratory Society/American Thoracic Society consensus statement for MBW recommends the rejection of measurements with leaks. However, it is unclear whether this is necessary for all types of leaks. Here, our aim was to 1) model and 2) apply air leaks, and 3) to assess their influence on the primary MBW outcomes of lung clearance index and functional residual capacity. We investigated the influence of air leaks at various locations (pre-, intra- and post-capillary), sizes, durations and stages of the washout...
January 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29483491/determination-of-cisplatin-in-human-blood-plasma-and-urine-using-liquid-chromatography-mass-spectrometry-for-oncological-patients-with-a-variety-of-fatty-tissue-mass-for-prediction-of-toxicity
#6
A Gerina-Berzina, S Hasnere, A Kolesovs, S Umbrashko, R Muceniece, I Nakurte
AIM: The research was aimed to analyze a level of triglycerides in blood serum as a possible new marker of toxicity, particularly in patients with excess body weight, receiving cisplatin. MATERIALS AND METHODS: Study involved 20 oncological patients with stage III lung cancer, who received palliative treatment with cisplatin. High-performance liquid chromatography was used for quantitative determination of pure cisplatin in urine and blood samples. Cisplatin concentration of the test samples was determined based on the data obtained from the calibration graph...
July 2017: Experimental Oncology
https://www.readbyqxmd.com/read/29449440/lung-clearance-index-to-monitor-treatment-response-in-pulmonary-exacerbations-in-preschool-children-with-cystic-fibrosis
#7
Jonathan H Rayment, Sanja Stanojevic, Stephanie D Davis, George Retsch-Bogart, Felix Ratjen
BACKGROUND: Antibiotic treatment for pulmonary symptoms in preschool children with cystic fibrosis (CF) varies among clinicians. The lung clearance index (LCI) is sensitive to early CF lung disease, but its utility to monitor pulmonary exacerbations in young children has not been assessed. OBJECTIVE: We aim to (1) understand how LCI changes during lower respiratory tract symptoms relative to a recent clinically stable measurement, (2) determine whether LCI can identify antibiotic treatment response and (3) compare LCI changes to changes in spirometric indices...
February 15, 2018: Thorax
https://www.readbyqxmd.com/read/29444773/lung-function-inflammation-and-endothelin-1-in-congenital-heart-disease-associated-pulmonary-arterial-hypertension
#8
Andrew Low, Sarah George, Luke Howard, Nicholas Bell, Ann Millar, Robert M R Tulloh
BACKGROUND: Breathlessness is the most common symptom in people with pulmonary arterial hypertension and congenital heart disease (CHD-APAH), previously thought to be caused by worsening PAH, but perhaps also by inflammation and abnormalities of lung function. We studied lung function and airway inflammation in patients with CHD-APAH and compared the results with controls. METHODS AND RESULTS: Sixty people were recruited into the study: 20 CHD-APAH, 20 CHD controls, and 20 healthy controls...
February 14, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29394172/the-emerging-spectrum-of-exposure-related-bronchiolitis
#9
Silpa D Krefft, Carlyne D Cool, Cecile S Rose
PURPOSE OF REVIEW: Exposure-related bronchiolitis is increasingly recognized as an important but challenging clinical diagnosis. Acute and chronic inhalational exposures are associated with variable clinical presentations and a spectrum of histopathologic abnormalities affecting the small airways. This review provides an overview of the histologic patterns and occupational settings for exposure-related bronchiolitis, along with recent advances in disease diagnosis and management. RECENT FINDINGS: The entire histopathologic spectrum of bronchiolitis (constrictive, obliterative, proliferative, lymphocytic, respiratory) has been reported in exposure-related bronchiolitis...
April 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29372944/determination-of-the-lung-clearance-index-lci-in-a-paediatric-cystic-fibrosis-cohort
#10
M Mulligan, L Collins, C P Dunne, L Keane, B Linnane
The pathogenesis of CF lung disease may start in infancy. Therefore, it is important to monitor the early stages of its progress. The Exhalyzer D is the first commercially available device designed to measure lung ventilation inhomogeneity at any age. This study was conducted to assess the performance and feasibility of using the Exhalyzer D in a paediatric CF clinic. A total of 91 subjects were recruited (23 controls, and 68 patients with CF). The majority of CF patients (79%) and controls (78%) completed at least two successful washouts...
September 18, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29368419/utility-of-single-versus-multiple-breath-washout-in-adult-asthma
#11
S Kjellberg, E Viklund, P D Robinson, O Zetterström, A-C Olin, P Gustafsson
Nitrogen multiple breath washout (N2 MBW) is a sensitive method to identify peripheral airway involvement in asthma, but is a time-consuming test. The N2 vital capacity single breath (VC SBW) test offers greater time efficiency, but concordance with N2 MBW is poorly understood. The prevalence of peripheral airway abnormality was determined by N2 MBW and N2 SBW tests in 194 asthmatic subjects aged 18-1 years. N2 MBW data were related to findings in 400 healthy controls, aged 17-71 years, while N2 SBW data were compared to findings in 224 healthy controls, aged 15-65 years, to derive equipment-specific reference values...
January 24, 2018: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29368042/primary-ciliary-dyskinesia-due-to-microtubular-defects-is-associated-with-worse-lung-clearance-index
#12
S Irving, M Dixon, M R Fassad, E Frost, J Hayward, K Kilpin, S Ollosson, A Onoufriadis, M P Patel, J Scully, S B Carr, H M Mitchison, M R Loebinger, C Hogg, A Shoemark, A Bush
PURPOSE: Primary ciliary dyskinesia (PCD) is characterised by repeated upper and lower respiratory tract infections, neutrophilic airway inflammation and obstructive airway disease. Different ultrastructural ciliary defects may affect lung function decline to different degrees. Lung clearance index (LCI) is a marker of ventilation inhomogeneity that is raised in some but not all patients with PCD. We hypothesised that PCD patients with microtubular defects would have worse (higher) LCI than other PCD patients...
January 24, 2018: Lung
https://www.readbyqxmd.com/read/29320566/the-effect-of-time-of-day-and-chest-physiotherapy-on-multiple-breath-washout-measures-in-children-with-clinically-stable-cystic-fibrosis
#13
Christian Voldby, Kent Green, Susanne Rosthøj, Thomas Kongstad, Lue Philipsen, Frederik Buchvald, Marianne Skov, Tania Pressler, Per Gustafsson, Kim G Nielsen
BACKGROUND: In this pilot study we investigated daytime variation of multiple breath nitrogen washout (N2MBW) measures in children with clinically stable cystic fibrosis. To our knowledge the effect of time-of-day on multiple breath washout measures in patients with cystic fibrosis has not previously been reported. Furthermore, we assessed the influence of chest physiotherapy on N2MBW measures. METHODS: Ten school children with cystic fibrosis performed N2MBW followed by spirometry and plethysmography in the morning and afternoon at three visits that were one month apart...
2018: PloS One
https://www.readbyqxmd.com/read/29275133/inert-gas-washout-in-bronchiolitis-obliterans-following-hematopoietic-cell-transplantation
#14
Sylvia Nyilas, Luzia Baumeler, Michael Tamm, Jörg P Halter, Spasenija Savic, Insa Korten, Anja Meyer, Florian Singer, Jakob R Passweg, Philipp Latzin, Daiana Stolz
BACKGROUND: Bronchiolitis obliterans syndrome (BOS) is a leading cause of chronic graft-vs-host disease (cGvHD) and is associated with mortality after allogeneic hematopoietic stem cell transplantation (alloHSCT). The nitrogen multiple breath washout test (N2 -MBW) measures ventilation inhomogeneity, a biomarker of central and peripheral airway obstruction. The aim of this study was to examine ventilation inhomogeneity according to cGvHD score and histologically defined bronchiolitis obliterans (BO)...
December 21, 2017: Chest
https://www.readbyqxmd.com/read/29228942/multiple-breath-washout-testing-in-adults-with-pulmonary-disease-and-healthy-controls-can-fewer-measurements-eventually-be-more
#15
Frederik Trinkmann, Johannes Götzmann, Daniel Saur, Michele Schroeter, Katharina Roth, Ksenija Stach, Martin Borggrefe, Joachim Saur, Ibrahim Akin, Julia D Michels
BACKGROUND: Multiple breath washout (MBW) became a valuable research tool assessing ventilation heterogeneity. However, routine clinical application still faces several challenges. Deriving MBW parameters from three technically acceptable measurements according to current recommendations prolongs test times. We therefore aimed to evaluate reporting only duplicate measurements in healthy adults and pulmonary disease. METHODS: One hundred and fifty-three subjects prospectively underwent conventional lung function testing and closed-circuit SF6 -MBW...
December 11, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29217601/novel-magnetic-resonance-technique-for-functional-imaging-of-cystic-fibrosis-lung-disease
#16
Sylvia Nyilas, Grzegorz Bauman, Gregor Sommer, Enno Stranzinger, Orso Pusterla, Urs Frey, Insa Korten, Florian Singer, Carmen Casaulta, Oliver Bieri, Philipp Latzin
Lung function tests are commonly used to monitor lung disease in cystic fibrosis (CF). While practical, they cannot locate the exact origin of functional impairment. Contemporary magnetic resonance imaging (MRI) techniques provide information on the location of disease but the need for contrast agents constrains their repeated application. We examined the correlation between functional MRI, performed without administration of contrast agent, and lung clearance index (LCI) from nitrogen multiple-breath washout (N2 -MBW)...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29177921/inhibitory-effects-and-related-molecular-mechanisms-of-total-flavonoids-in-mosla-chinensis-maxim-against-h1n1-influenza-virus
#17
Xiao-Xia Zhang, Qiao-Feng Wu, Yun-Liang Yan, Feng-Ling Zhang
OBJECTIVE: The Shixiangru (Mosla chinensis Maxim) total flavonoids (STF) mainly contain luteolin and apigenin. The study aims to examine the inhibitory effects of STF on anti-H1N1 influenza virus and its related molecular mechanisms in pneumonia mice. METHODS: The viral pneumonia mice were treated with Ribavirin or various doses of STF. We observed histological changes of lung by immunohistochemistry and measured lung index to value anti-influenza virus effects of STF...
February 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29176899/supine-posture-changes-lung-volumes-and-increases-ventilation-heterogeneity-in-cystic-fibrosis
#18
Laurie J Smith, Kenneth A Macleod, Guilhem J Collier, Felix C Horn, Helen Sheridan, Ina Aldag, Chris J Taylor, Steve Cunningham, Jim M Wild, Alex Horsley
INTRODUCTION: Lung Clearance Index (LCI) is recognised as an early marker of cystic fibrosis (CF) lung disease. The effect of posture on LCI however is important when considering longitudinal measurements from infancy and when comparing LCI to imaging studies. METHODS: 35 children with CF and 28 healthy controls (HC) were assessed. Multiple breath washout (MBW) was performed both sitting and supine in triplicate and analysed for LCI, Scond, Sacin, and lung volumes...
2017: PloS One
https://www.readbyqxmd.com/read/29157654/an-innovative-lung-model-for-multiple-breath-washout-testing-in-health-and-disease
#19
Pinelopi Anagnostopoulou, Sarah Vomsattel, Anne-Christiane Kentgens, Marisa Guidi, Severin Binggeli, Lena Kohler, Florian Singer, Philipp Latzin, Dominik Obrist
BACKGROUND: Multiple breath washout (MBW) is a lung function test that identifies the degree of ventilation inhomogeneity (VI) in the lungs. In vitro validation of MBW devices is recommended. So far, plastic lung models for MBW validation ignored variable degrees of VI. Our primary aim was to create a plastic lung model applicable for physiological lung volumes and variable VI. METHODS: A plastic box divided in two chambers was filled with water and ventilated in various lung volumes and respiratory rates...
November 10, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29123150/lung-clearance-index-and-quantitative-computed-tomography-of-post-infectious-bronchiolitis-obliterans-in-infants
#20
Yoon Hee Kim, Hyun Joo Shin, In Suk Sol, Soo Yeon Kim, Jong Deok Kim, Haesung Yoon, Kyung Won Kim, Myung-Joon Kim, Mi-Jung Lee, Myung Hyun Sohn
Post-infectious bronchiolitis obliterans (BO) could be diagnosed via spirometry and chest computed tomography (CT); however, these tests are limited in infants. We aimed to evaluate the utility of lung clearance index (LCI) and air-trapping lung volume from chest CT in infants. This prospective study included 20 infants (mean age, 10.9 ± 6.3 months) diagnosed with post-infectious BO between 2009 and 2016. All subjects underwent multiple breath washout tests. For quantitative analysis of chest CT, the mean lung area attenuation value was used as an individual cutoff to determine the air-trapping lung volume...
November 9, 2017: Scientific Reports
keyword
keyword
39660
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"