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https://www.readbyqxmd.com/read/28317233/pirfenidone-and-nintedanib-for-pulmonary-fibrosis-in-clinical-practice-tolerability-and-adverse-drug-reactions
#1
Jonathan A Galli, Aloknath Pandya, Michelle Vega-Olivo, Chandra Dass, Huaqing Zhao, Gerard J Criner
BACKGROUND AND OBJECTIVE: The real-world tolerability of pirfenidone and nintedanib in non-clinical trial patients is unknown. Many patients with pulmonary fibrosis have significant medical co-morbidities or baseline characteristics that exclude them from clinical trial participation. METHODS: We conducted a retrospective chart review study on subjects prescribed nintedanib or pirfenidone for pulmonary fibrosis treatment (any aetiology) from September 2014 to February 2016...
March 20, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28303059/marginal-pulmonary-function-is-associated-with-poor-short-and-long-term-outcomes-in-lung-cancer-surgery
#2
Naoki Ozeki, Koji Kawaguchi, Toshiki Okasaka, Takayuki Fukui, Koichi Fukumoto, Shota Nakamura, Shuhei Hakiri, Kohei Yokoi
We sought to determine the short- and long-term prognoses among 'marginal-risk' non-small cell lung cancer patients who have a predicted postoperative- (ppo) forced expiratory volume in the first second (FEV1) of 30-60% and/or a ppo-diffusing capacity of the lung for carbon monoxide (DLCO) of 30-60%. The present study included 73 'marginal-risk' and 318 'normal-risk' patients who underwent anatomical resection for clinical stage I lung cancer between 2008 and 2012. The rates of postoperative morbidity, prolonged hospital stay, and overall survival were assessed...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28300570/idiopathic-interstitial-pneumonia-associated-with-autoantibodies-a-large-case-series-followed-over-one-year
#3
Bridget F Collins, Charles F Spiekerman, Megan A Shaw, Lawrence A Ho, Jennifer Hayes, Carolyn A Spada, Caroline M Stamato, Ganesh Raghu
BACKGROUND: Some patients with autoimmune characteristics and idiopathic interstitial pneumonia (IIP), particularly usual interstitial pneumonia (UIP), do not fit neatly into the category of connective tissue disease associated interstitial lung disease (CTD-ILD), idiopathic pulmonary fibrosis (IPF) or recently proposed yet to be validated criteria for interstitial pneumonia with autoimmune features (IPAF). Outcomes of these patients are unknown. METHODS: Retrospective single center study; ANOVA analyses compared differences in mean change in forced vital capacity (FVC) and diffusion capacity (DLCO) over 1-year among 124 well defined patients (20 AI-ILD [positive autoantibodies with or without symptoms of CTD], 15 IPAF, 36 CTD-ILD, 53 "Lone-IPF" [patients with IPF without any autoantibodies]) RESULTS: 75% of patients with AI-ILD, 33% IPAF, and 33% CTD-ILD had UIP...
March 11, 2017: Chest
https://www.readbyqxmd.com/read/28293128/exhaled-nitric-oxide-in-systemic-sclerosis-lung-disease
#4
Natalie K Kozij, John T Granton, Philip E Silkoff, John Thenganatt, Shobha Chakravorty, Sindhu R Johnson
Background. Exhaled nitric oxide (eNO) is a potential biomarker to distinguish systemic sclerosis (SSc) associated pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD). We evaluated the discriminative validity, feasibility, methods of eNO measurement, and magnitude of differences across lung diseases, disease-subsets (SSc, systemic lupus erythematosus), and healthy-controls. Methods. Consecutive subjects in the UHN Pulmonary Hypertension Programme were recruited. Exhaled nitric oxide was measured at 50 mL/s intervals using chemiluminescent detection...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28287506/assessment-of-pulmonary-capillary-blood-volume-membrane-diffusing-capacity-and-intrapulmonary-arteriovenous-anastomoses-during-exercise
#5
Vincent Tedjasaputra, Sean van Diepen, Sophie É Collins, Wade M Michaelchuk, Michael K Stickland
Exercise is a stress to the pulmonary vasculature. With incremental exercise, the pulmonary diffusing capacity (DLCO) must increase to meet the increased oxygen demand; otherwise, a diffusion limitation may occur. The increase in DLCO with exercise is due to increased capillary blood volume (Vc) and membrane diffusing capacity (Dm). Vc and Dm increase secondary to the recruitment and distension of pulmonary capillaries, increasing the surface area for gas exchange and decreasing pulmonary vascular resistance, thereby attenuating the increase in pulmonary arterial pressure...
February 20, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28285692/chest-wall-resection-for-non-small-cell-lung-cancer-a-case-matched-study-of-postoperative-pulmonary-function-and-quality-of-life
#6
Ming Liu, Jason A Wampfler, Jie Dai, Ruchi Gupta, Zhiqiang Xue, Shawn M Stoddard, Stephen D Cassivi, Gening Jiang, Ping Yang
BACKGROUND: To assess the pulmonary function and quality of life (QOL) after chest wall resection for non-small cell lung cancer. MATERIAL AND METHODS: One hundred and thirty-five patients (cases) who underwent pulmonary resection with chest wall removal were identified from January 1997 to December 2015. Propensity score matching (1:3) was applied to balance known confounders for pulmonary function and QOL between the cases and the control group who underwent pulmonary resection without chest wall invasion...
April 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28280109/exercise-induced-dehydration-alters-pulmonary-function-but-does-not-modify-airway-responsiveness-to-dry-air-in-athletes-with-mild-asthma
#7
Andrew J Simpson, Lee M Romer, Pascale Kippelen
BACKGROUND: Local airway water loss is the main physiological trigger for exercise-induced bronchoconstriction (EIB). AIM: To investigate the effects of whole-body water loss on airway responsiveness and pulmonary function in athletes with mild asthma and/or EIB. METHODS: Ten recreational athletes with a doctor diagnosis of mild asthma and/or EIB completed a randomized, cross-over study. Pulmonary function tests (spirometry, whole-body plethysmography and diffusing capacity for carbon monoxide [DLCO]) were conducted before and after three conditions: i) 2 h exercise in the heat with no fluid intake (dehydration); ii) 2 h exercise with ad libitum fluid intake (control); and iii) time-matched rest period (rest)...
March 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28277322/utilizing-forced-vital-capacity-to-predict-low-lung-compliance-and-select-intraoperative-tidal-volume-during-thoracic-surgery
#8
Nir Hoftman, Eric Eikermann, John Shin, Jack Buckley, Kaveh Navab, Fereidoun Abtin, Tristan Grogan, Maxime Cannesson, Aman Mahajan
BACKGROUND: Tidal volume selection during mechanical ventilation utilizes dogmatic formulas that only consider a patient's predicted body weight (PBW). In this study, we investigate whether forced vital capacity (FVC) (1) correlates better to total lung capacity (TLC) than PBW, (2) predicts low pulmonary compliance, and (3) provides an alternative method for tidal volume selection. METHODS: One hundred thirty thoracic surgery patients had their preoperative TLC calculated via 2 methods: (1) pulmonary function test (PFT; TLCPFT) and (2) computed tomography 3D reconstruction (TLCCT)...
March 8, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28275485/serum-kl-6-and-surfactant-protein-d-as-monitoring-and-predictive-markers-of-interstitial-lung-disease-in-patients-with-systemic-sclerosis-and-mixed-connective-tissue-disease
#9
Hideaki Yamakawa, Eri Hagiwara, Hideya Kitamura, Yumie Yamanaka, Satoshi Ikeda, Akimasa Sekine, Tomohisa Baba, Koji Okudela, Tae Iwasawa, Tamiko Takemura, Kazuyoshi Kuwano, Takashi Ogura
BACKGROUND: Interstitial lung disease (ILD) is frequent complication of systemic sclerosis (SSc) and mixed connective tissue disease (MCTD). The disease is heterogeneous, and its outcome is unpredictable. Some patients have severe and progressive deterioration of ILD, which is the leading cause of mortality. We aimed to determine whether serum levels of Krebs von den Lungen-6 (KL-6) and surfactant protein-D (SP-D) correlate with SSc/MCTD-associated ILD activity. METHODS: We retrospectively analyzed the medical records of 40 patients with SSc/MCTD-associated ILD: 29 patients with SSc and 11 patients with MCTD...
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28275476/serum-kl-6-in-pulmonary-alveolar-proteinosis-china-compared-historically-with-germany-and-japan
#10
Wen-Liang Guo, Zi-Qing Zhou, Lu Chen, Zhu-Quan Su, Chang-Hao Zhong, Yu Chen, Shi-Yue Li
BACKGROUND: KL-6 is a biomarker of the severity of pulmonary alveolar proteinosis (PAP). We noticed a significant difference in the mean serum KL-6 level between Japanese and Caucasian patients. To assess the clinical value of serum KL-6 in Chinese PAP patients, and to compare the differences in serum KL-6 levels in Chinese patients and patients of other ethnicities. METHODS: From 2014-2016, we prospectively examined 37 Chinese Han patients with PAP, measured their serum KL-6 levels, evaluated the correlation between initial KL-6 levels and clinical variables, and compared our results with studies from Japan and Germany (similar methods were used)...
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28258938/ventilation-distribution-and-small-airway-function-in-patients-with-systemic-sclerosis
#11
B R A Silva, R Rufino, C H Costa, V S Vilela, R A Levy, A J Lopes
BACKGROUND: Despite the importance of traditional pulmonary function tests (PFTs) in managing systemic sclerosis (SSc), many patients with pulmonary disease diagnosed by computed tomography (CT) present with normal PFTs. OBJECTIVE: To evaluate the efficacy of the nitrogen single-breath washout (N2SBW) test in diagnosing SSc and to correlate N2SBW parameters with the PFT indexes used in the follow-up of these patients, clinical data, and CT findings. METHODS: Cross-sectional study in which 52 consecutive SSc patients were subjected to spirometry, body plethysmography, analysis of the diffusing capacity for carbon monoxide (DLCO), analysis of respiratory muscle strength, N2SBW testing, and CT analysis...
March 1, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28248548/lung-function-in-south-african-adolescents-infected-perinatally-with-hiv-and-treated-long-term-with-antiretroviral-therapy
#12
Leah Nyawira Githinji, Diane M Gray, Sipho Hlengwa, Landon Myer, Heather J Zar
RATIONALE: Lung disease is a common cause of mortality and morbidity in HIV-infected adolescents, but there is limited information on the spectrum of lung function impairment in adolescents on antiretroviral therapy. OBJECTIVES: To investigate lung function in HIV-infected adolescents on antiretroviral therapy in the Cape Town Adolescent Antiretroviral Cohort. METHODS: A total of 515 South African adolescents aged 9 to 14 years, stable on antiretroviral therapy for at least 6 months, underwent baseline lung function testing...
March 1, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28247041/volatile-organic-compounds-in-exhaled-breath-of-idiopathic-pulmonary-fibrosis-for-discrimination-from-healthy-subjects
#13
Yu-Ichi Yamada, Gen Yamada, Mitsuo Otsuka, Hirotaka Nishikiori, Kimiyuki Ikeda, Yasuaki Umeda, Hirofumi Ohnishi, Koji Kuronuma, Hirofumi Chiba, Jörg Ingo Baumbach, Hiroki Takahashi
Purpose Human breath analysis is proposed with increasing frequency as a useful tool in clinical application. We performed this study to find the characteristic volatile organic compounds (VOCs) in the exhaled breath of patients with idiopathic pulmonary fibrosis (IPF) for discrimination from healthy subjects. Methods VOCs in the exhaled breath of 40 IPF patients and 55 healthy controls were measured using a multi-capillary column and ion mobility spectrometer. The patients were examined by pulmonary function tests, blood gas analysis, and serum biomarkers of interstitial pneumonia...
March 1, 2017: Lung
https://www.readbyqxmd.com/read/28223154/idiopathic-and-systemic-sclerosis-associated-pulmonary-arterial-hypertension-a-comparison-of-demographic-haemodynamic-and-magnetic-resonance-imaging-characteristics-and-outcomes
#14
Sheila Ramjug, Nehal Hussain, Judith Hurdman, Catherine Billings, Athanasios Charampopoulos, Charlie A Elliot, David G Kiely, Ian Sabroe, Smitha Rajaram, Andrew J Swift, Robin Condliffe
BACKGROUND: Previous studies have identified survival in systemic sclerosis (SSc)-associated pulmonary arterial hypertension (SSc-PAH) to be worse than in idiopathic pulmonary arterial hypertension (IPAH). We investigated differences between these conditions by comparing demographic, haemodynamic and radiological characteristics and outcomes in a large cohort of incident patients. METHODS: 651 patients diagnosed with IPAH or SSc-associated pre-capillary pulmonary hypertension were included...
February 18, 2017: Chest
https://www.readbyqxmd.com/read/28218012/reference-values-for-pulmonary-diffusing-capacity-for-adult-native-finns
#15
Annette Kainu, Jyri Toikka, Esko Vanninen, Kirsi L Timonen
Measurement standards for pulmonary diffusing capacity were updated in 2005 by the ATS/ERS Task Force. However, in Finland reference values published in 1982 by Viljanen et al. have been used to date. The main aim of this study was to produce updated reference models for single-breath diffusing capacity for carbon monoxide for Finnish adults. Single-breath diffusing capacity for carbon monoxide was measured in 631 healthy non-smoking volunteers (41.5% male). Reference values for diffusing capacity (DLCO), alveolar volume (VA), diffusing capacity per unit of lung volume (DLCO/VA), and lung volumes were calculated using a linear regression model...
April 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28198571/pulmonary-mri-morphometry-modeling-of-airspace-enlargement-in-chronic-obstructive-pulmonary-disease-and-alpha-1-antitrypsin-deficiency
#16
Alexei Ouriadov, Eric Lessard, Khadija Sheikh, Grace Parraga
PURPOSE: We generated lung morphometry measurements using single-breath diffusion-weighted MRI and three different acinar duct models in healthy participants and patients with emphysema stemming from chronic obstructive lung disease (COPD) and alpha-1 antitrypsin deficiency (AATD). METHODS: Single-breath-inhaled (3) He MRI with five diffusion sensitizations (b-value = 0, 1.6, 3.2, 4.8, and 6.4 s/cm(2) ) was used, and signal intensities were fit using a cylindrical and single-compartment acinar-duct model to estimate MRI-derived mean linear intercept (Lm ) and surface-to-volume ratio (S/V)...
February 15, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28194083/asbestos-induced-lung-disease-in-small-scale-clutch-manufacturing-workers
#17
Dipti Gothi, Tanushree Gahlot, Ram B Sah, Mayank Saxena, U C Ojha, Anand K Verma, Sonam Spalgais
BACKGROUND: The crocidolite variety of asbestos is banned. However, chrysotile, which is not prohibited, is still used in developing countries in making products such as clutch plate. Fourteen workers from a small-scale clutch plate-manufacturing factory were analyzed for asbestos-induced lung disease as one of their colleagues had expired due to asbestosis. AIMS: This study was conducted to evaluate the awareness of workers, the prevalence and type of asbestos-induced lung disease, and the sensitivity and specificity of diffusion test...
May 2016: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28137497/interstitial-pneumonia-with-autoimmune-features-clinical-radiologic-and-histological-characteristics-and-outcome-in-a-series-of-57-patients
#18
Kais Ahmad, Thomas Barba, Delphine Gamondes, Marylise Ginoux, Chahera Khouatra, Paolo Spagnolo, Mary Strek, Françoise Thivolet-Béjui, Julie Traclet, Vincent Cottin
BACKGROUND: Interstitial pneumonia with autoimmune features (IPAF) has recently been defined by an international Taskforce to characterize interstitial lung disease associated with systemic manifestations limited to subtle serological and clinical autoimmune abnormalities and not fulfilling the international criteria for the diagnosis of a given connective tissue disease. OBJECTIVE: to report on a series of patients with IPAF, and to compare their outcome to that of a cohort of patients with idiopathic pulmonary fibrosis (IPF)...
February 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28122034/a-low-peripheral-blood-cd4-cd8-ratio-is-associated-with-pulmonary-emphysema-in-hiv
#19
Matthew Triplette, Engi F Attia, Kathleen M Akgün, Guy W Soo Hoo, Matthew S Freiberg, Adeel A Butt, Cherry Wongtrakool, Matthew Bidwell Goetz, Sheldon T Brown, Christopher J Graber, Laurence Huang, Kristina Crothers
OBJECTIVES: The prevalence of emphysema is higher among HIV-infected (HIV+) individuals compared to HIV-uninfected persons. While greater tobacco use contributes, HIV-related effects on immunity likely confer additional risk. Low peripheral blood CD4+ to CD8+ T-lymphocyte (CD4/CD8) ratio may reflect chronic inflammation in HIV and may be a marker of chronic lung disease in this population. Therefore, we sought to determine whether the CD4/CD8 ratio was associated with chronic obstructive pulmonary disease (COPD), particularly the emphysema subtype, in a cohort of HIV+ subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28120553/what-makes-a-good-pediatric-transplant-lung-insights-from-in-vivo-lung-morphometry-with-hyperpolarized-3-he-magnetic-resonance-imaging
#20
Emily F Fishman, James D Quirk, Stuart C Sweet, Jason C Woods, David S Gierada, Mark S Conradi, Marilyn J Siegel, Dmitriy A Yablonskiy
Obtaining information on transplanted lung microstructure is an important part of the current care for monitoring transplant recipients. However, until now this information was only available from invasive lung biopsy. The objective of this study was to evaluate the use of an innovative non-invasive technique, in vivo lung morphometry with hyperpolarized ³He MRI-to characterize lung microstructure in the pediatric lung transplant population. This technique yields quantitative measurements of acinar airways' (alveolar ducts and sacs) parameters, such as acinar airway radii and alveolar depth...
January 24, 2017: Pediatric Transplantation
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