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https://www.readbyqxmd.com/read/29156335/thyroid-disruption-and-reduced-mental-development-in-children-from-an-informal-e-waste-recycling-area-a-mediation-analysis
#1
Lian Liu, Bo Zhang, Kun Lin, Yuling Zhang, Xijin Xu, Xia Huo
This paper aims to evaluate the effects of thyroid disruption on the mental development of children. A total of 258 three-year-old children in Guiyu (e-waste-exposed group) and Nanao (reference group), China were examined. FT3, FT4, TSH, lead (BPb) and cadmium (BCd) in blood were determined, and cognitive and language scores of children were assessed based on the Bayley Scales of Infant Development III. Stepwise multiple regression was used to estimate the relationship between heavy metals and cognitive and language scores; mediation analysis was performed to determine whether thyroid disruption was mechanistically involved...
November 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/29153684/impact-of-maternal-serum-uric-acid-on-perinatal-outcome-in-women-with-hypertensive-disorders-of-pregnancy-a-prospective-study
#2
Naina Kumar, Amit Kant Singh, Bhavya Maini
INTRODUCTION: Worldwide hypertensive disorder of pregnancy is major cause of maternal and perinatal morbidity, mortality. AIM: To study impact of maternal serum uric acid on perinatal outcome in women with hypertensive disorder of pregnancy. METHODOLOGY: Present study was conducted in Obstetrics and Gynecology Department of rural tertiary care centre of Northern India over seven months (October 2016-May 2017). Total 110 pregnant women >-34weeks with hypertensive disorder of pregnancy were divided into three groups; Gestational hypertension (n = 35), Pre-eclampsia (n = 49), Eclampsia (n = 26)...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29145001/in-vitro-and-in-vivo-evaluation-of-10-hydroxycamptothecin-loaded-poly-n-butyl-cyanoacrylate-nanoparticles-prepared-by-miniemulsion-polymerization
#3
Xin Jin, Sajid Asghar, Xieting Zhu, Zhipeng Chen, Cihui Tian, Lining Yin, Qineng Ping, Yanyu Xiao
In this paper, 10-hydroxycamptothecin (HCPT)-loaded poly (n-butyl cyanoacrylate) nanoparticles (HCPT-PBCA-NPs) co-modified with polysorbate 80, soybean phospholipids, and polyethylene glycol (100) monostearate were successfully prepared via miniemulsion polymerization, and were characterized for particle size, morphology, zeta potential, encapsulation efficiency (EE) and drug loading capacity (DL). The chemical structure of HCPT-PBCA-NPs and the state of HCPT in the PBCA-NPs were investigated by DSC, FTIR and (1)H NMR...
November 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29137465/a-trial-on-the-effects-of-magnesium-zinc-calcium-vitamin-d-co-supplementation-on-glycemic-control-and-markers-of-cardio-metabolic-risk-in-women-with-polycystic-ovary-syndrome
#4
Mehri Jamilian, Maryam Maktabi, Zatollah Asemi
BACKGROUND: There is scarce data on the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and markers of cardio-metabolic risk among women with polycystic ovary syndrome (PCOS). The objective of this study was to assess the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and markers of cardio-metabolic risk in women with PCOS. METHODS: Sixty PCOS women were randomized into two groups and treated with 100 mg of magnesium, 4 mg of zinc, 400 mg of calcium plus 200 IU of vitamin D supplements (n = 30) or placebo (n = 30) twice a day for 12 weeks...
October 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29133204/investigating-phase-separation-in-amorphous-solid-dispersions-via-raman-mapping
#5
Christian Luebbert, Christian Klanke, Gabriele Sadowski
The bioavailability of poorly-water-soluble active pharmaceutical ingredients (APIs) can be significantly improved by so-called amorphous solid dispersions (ASDs). However, the long-term stability of ASDs might be impaired by API recrystallization and/or amorphous phase separation (APS). So far, no methods have been reported to quantify APS in ASDs. In this work, phase-separation kinetics as well as the compositions of the two amorphous phases evolving due to APS were quantitatively determined for the first time using confocal Raman spectroscopy...
November 11, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29121661/high-prevalence-of-non-communicable-diseases-and-associated-risk-factors-amongst-adults-living-with-hiv-in-cambodia
#6
Pheak Chhoun, Sovannary Tuot, Anthony D Harries, Nang Thu Thu Kyaw, Khuondyla Pal, Phalkun Mun, Carrine Brody, Gitau Mburu, Siyan Yi
BACKGROUND: With rapid expansion of antiretroviral therapy for HIV, there are rising life expectancies among people living with HIV. As a result, co-morbidity from non-communicable diseases in those living and aging with HIV is increasingly being reported. Published data on this issue have been limited in Cambodia. The aim of this study was to determine the prevalence of diabetes mellitus, hypertension and hypercholesterolemia and associated risk factors in adults living with HIV in Cambodia...
2017: PloS One
https://www.readbyqxmd.com/read/29120677/relationships-between-25-oh-d-concentration-sarcopenia-and-homa-ir-in-postmenopausal-korean-women
#7
J H Lee, S Kim, M K Kim, B H Yun, S Cho, Y S Choi, B S Lee, S K Seo
OBJECTIVE: Sarcopenia and insulin resistance are common co-morbidities in the elderly and are known to be associated with vitamin D deficiency. However, no previous studies have investigated interactions between all three of these factors. We aimed to investigate the relationship between 25-hydroxyvitamin D concentration, sarcopenia, and insulin resistance in postmenopausal Korean women. METHODS: This study used data from the Korea National Health and Nutrition Examination Survey 2008-2011...
November 9, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29118985/acute-development-of-cushing-syndrome-in-an-hiv-infected-child-on-atazanavir-ritonavir-based-antiretroviral-therapy
#8
Gueorgui Dubrocq, Andrea Estrada, Shannon Kelly, Natella Rakhmanina
An 11-year-old male with perinatally acquired human immune deficiency virus (HIV) infection on antiretroviral regimen, which included abacavir plus lamivudine (Epzicom), didanosine, ritonavir and atazanavir presented with bilateral axillary striae, increased appetite, fatigue, facial swelling and acute weight gain. Two months prior to presentation, the patient had received a diagnostic and therapeutic intra-articular triamcinolone injection in the knee for pain relief and subsequently became progressively swollen in the face, developed striae bilaterally at the axillae, experienced increased appetite, fatigue and an 8 pound weight gain...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29106807/computer-aided-design-of-architecture-of-degradable-tissue-engineering-scaffolds
#9
M K Heljak, K J Kurzydlowski, W Swieszkowski
One important factor affecting the process of tissue regeneration is scaffold stiffness loss, which should be properly balanced with the rate of tissue regeneration. The aim of the research reported here was to develop a computer tool for designing the architecture of biodegradable scaffolds fabricated by melt-dissolution deposition systems (e.g. Fused Deposition Modeling) to provide the required scaffold stiffness at each stage of degradation/regeneration. The original idea presented in the paper is that the stiffness of a tissue engineering scaffold can be controlled during degradation by means of a proper selection of the diameter of the constituent fibers and the distances between them...
November 6, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/29100464/core-shell-gene-carriers-with-different-lengths-of-plga-chains-to-transfect-endothelial-cells
#10
Xinghong Duo, Qian Li, Jun Wang, Juan Lv, Xuefang Hao, Yakai Feng, Xiangkui Ren, Changcan Shi, Wencheng Zhang
In order to improve the transfection efficiency and reduce the cytotoxicity of gene carriers, many strategies have been used to develop novel gene carriers. In this study, five complex micelles (MSP(2 k), MSP(4 k), MSP(6 k), MSP(8 k), and MSP(10 k)) were prepared from methoxy-poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) (mPEG-b-PLGA) and sorbitol-poly(d,l-lactide-co-glycolide)-graft-PEI (sorbitol-PLGA-g-PEI, where the designed molecular weights of PLGA chains were 2 kDa, 4 kDa, 6 kDa, 8 kDa, and 10 kDa, respectively) copolymers by a self-assembly method, and the mass ratio of mPEG-b-PLGA to sorbitol-PLGA-g-PEI was 1/3...
November 8, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29099813/stress-induced-hyperglycemia-but-not-diabetic-hyperglycemia-is-associated-with-higher-mortality-in-patients-with-isolated-moderate-and-severe-traumatic-brain-injury-analysis-of-a-propensity-score-matched-population
#11
Cheng-Shyuan Rau, Shao-Chun Wu, Yi-Chun Chen, Peng-Chen Chien, Hsiao-Yun Hsieh, Pao-Jen Kuo, Ching-Hua Hsieh
Background: Admission hyperglycemia is associated with higher morbidity and mortality in patients with traumatic brain injury (TBI). Stress-induced hyperglycemia (SIH), a form of hyperglycemia induced by the stress response, is associated with increased patient mortality following TBI. However, admission hyperglycemia occurs not only in SIH but also in patients with diabetic hyperglycemia (DH). Current information regarding whether trauma patients with SIH represent a distinct group with differential outcomes compared to those with DH remains limited...
November 3, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29089762/vorinostat-eluting-poly-dl-lactide-co-glycolide-nanofiber-coated-stent-for-inhibition-of-cholangiocarcinoma-cells
#12
Tae Won Kwak, Hye Lim Lee, Yeon Hui Song, Chan Kim, Jungsoo Kim, Sol-Ji Seo, Young-Il Jeong, Dae Hwan Kang
PURPOSE: The aim of this study was to fabricate a vorinostat (Zolinza™)-eluting nanofiber membrane-coated gastrointestinal (GI) stent and to study its antitumor activity against cholangiocarcinoma (CCA) cells in vitro and in vivo. METHODS: Vorinostat and poly(DL-lactide-co-glycolide) dissolved in an organic solvent was sprayed onto a GI stent to make a nanofiber-coated stent using an electro-spinning machine. Intact vorinostat and vorinostat released from nanofibers was used to assess anticancer activity in vitro against various CCA cells...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29076174/new-technology-mimics-physiologic-pulsatile-flow-during-cardiopulmonary-bypass
#13
Gengo Sunagawa, Jamshid H Karimov, Raymond Dessoffy, Nicole Byram, Patrick Grady, Martin Sinkewich, Jeffrey P Naber, Douglas Vincent, Shinji Okano, Robert D Stewart, Shiva M Sale, Nader Moazami, Kiyotaka Fukamachi
The VentriFlo True Pulse Pump (Design Mentor, Inc., Pelham, NH, USA) is the first blood pump designed to mimic human arterial waveforms in a standard oxygenation circuit. Our aim was to demonstrate the feasibility and safety of this pump in preparation for future studies to determine possible clinical advantages. We studied four piglets (41.4-46.2 kg): three with an implanted VentriFlo pulsatile pump and one with the nonpulsatile ROTAFLOW pump (MAQUET Holding B.V. & Co. KG, Rastatt, Germany) as a control. Hemodynamics was monitored during 6-h cardiopulmonary bypass (CPB) support and for 2 h after weaning off CPB...
October 27, 2017: Artificial Organs
https://www.readbyqxmd.com/read/29067698/double-trouble-co-occurrence-of-testosterone-deficiency-and-body-fatness-associated-with-all-cause-mortality-in-us-men
#14
D S Lopez, X Qiu, S Advani, K K Tsilidis, M Khera, J Kim, A Morgentaler, R Wang, S Canfield
BACKGROUND: Testosterone deficiency (TD, total testosterone ≤ 350 ng/dL [12.15 nmol/L]) and obesity epidemic are growing in parallel in the United States. Yet the sequelae of TD and obesity on the risk of mortality remains unclear. OBJECTIVE: To investigate whether the co-occurrence of TD and overall obesity (body mass index ≥ 30 kg/m(2) ), and abdominal obesity (waist circumference ≥ 102 cm), is associated with a risk of all-cause mortality in American men...
October 25, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29063886/evaluation-of-concurrent-malaria-and-dengue-infections-among-febrile-patients
#15
Parul D Shah, Tanmay K Mehta
CONTEXT: Despite a wide overlap between endemic areas for two important vector-borne infections, malaria and dengue, published reports of co-infections are scarce till date. AIMS: To find the incidence of dengue and malaria co-infection as well as to ascertain the severity of such dengue and malaria co-infection based on clinical and haematological parameters. SETTING AND DESIGN: Observational, retrospective cross-sectional study was designed including patients who consulted the tertiary care hospital of Ahmedabad seeking treatment for fever compatible with malaria and/or dengue...
July 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29062181/micronutrients-drift-during-daily-and-weekly-iron-supplementation-in-non-anaemic-and-anaemic-pregnancy
#16
Hari Shankar, Neeta Kumar, Rajat Sandhir, Suneeta Mittal, Tulsi Adhikari, Arun Kumar, D N Rao
AIMS: Pregnancy is a phenomenon associated with dynamic changes in physical, mental and biochemical status of body and demands increased nutritional intake for developing foetus. The level of various micronutrients which act as co-factors for antioxidant enzymes or it-self as antioxidants gets altered with the progression of pregnancy. The present longitudinal study summarized the trend of selected micronutrients level in anaemic (AP) and non-anaemic primigravida (NAP) supplemented with daily and weekly oral iron folic acid (IFA) tablet during pregnancy and postpartum...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29036974/-the-impact-of-hydrogen-sulfide-on-the-heme-oxygenase-1-carbon-monoxide-system-in-coxsackie-virus-b3-induced-myocarditis-in-mice
#17
S Y Zhang, T T Wu, Y Ren, T H Xia, R Z Wu
Objective: To explore the impact of hydrogen sulfide (H(2)S) on the heme oxygenase-1/carbon monoxide pathway in Coxsackie virus B3 (CVB3)-induced murine myocarditis (VMC) model. Method: A total of 70 inbred male Balb/c mouse (4-6 weeks old) were randomized into the following four groups: Normal, VMC, PAG and NaHS (n=10 for Normal, n=20 for VMC, PAG and NaHS groups). Mice in Normal group were non-infected mice treated with intraperitoneal injection of sterile phosphate-buffered saline daily for 10 days.Mice in VMC group received intraperitoneal CVB3 injection (0...
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29017147/iontophoretic-transdermal-delivery-using-chitosan-coated-plga-nanoparticles-for-positively-charged-drugs
#18
Issei Takeuchi, Tomoyoshi Takeshita, Takaaki Suzuki, Kimiko Makino
Recently, poly(dl-lactide-co-glycolide) (PLGA) nanoparticles prepared using a combination of an antisolvent diffusion method with preferential solvation was shown to be beneficial for the iontophoretic transdermal delivery of therapeutic agents. Also, this preparation method can contain a hydrophilic drug. However, since PLGA nanoparticles were negatively charged, it was difficult to apply iontophoresis for positively charged hydrophilic drugs. In this study, we prepared positively charged PLGA nanoparticles containing donepezil hydrochloride (DP)...
October 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28989119/effects-of-protein-coated-nanofibers-on-conformation-of-gingival-fibroblast-spheroids-potential-utility-for-connective-tissues-regeneration
#19
Gili Kaufman, Ryan Whitescarver, Laiz Nunes, Xavier-Lewis Palmer, Drago Skrtic, Wojtek Tutak
Deep wounds in the gingiva caused by trauma or surgery require a rapid and robust healing of connective tissues. We propose utilizing gas-brushed nanofibers coated with collagen and fibrin for that purpose. Our hypotheses are that protein-coated nanofibers will: (i) attract and mobilize cells in various spatial orientations, and (ii) regulate the expression levels of specific extracellular matrix (ECM)-associated proteins, determining the initial conformational nature of dense and soft connective tissues. Gingival fibroblast monolayers and 3D spheroids were cultured on ECM substrate and covered with gas-blown poly-(DL-lactide-co-glycolide) (PLGA) nanofibers (uncoated/coated with collagen and fibrin)...
October 9, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28974008/higher-mortality-in-trauma-patients-is-associated-with-stress-induced-hyperglycemia-but-not-diabetic-hyperglycemia-a-cross-sectional-analysis-based-on-a-propensity-score-matching-approach
#20
Cheng-Shyuan Rau, Shao-Chun Wu, Yi-Chun Chen, Peng-Chen Chien, Hsiao-Yun Hsieh, Pao-Jen Kuo, Ching-Hua Hsieh
Background: Stress-induced hyperglycemia (SIH) is a form of hyperglycemia secondary to stress and commonly occurs in patients with trauma. Trauma patients with SIH have been reported to have an increased risk of mortality. However, information regarding whether these trauma patients with SIH represent a distinct group with differential outcomes when compared to those with diabetic hyperglycemia (DH) remains limited. Methods: Diabetes mellitus (DM) was determined by patient history and/or admission glycated hemoglobin (HbA1c) ≥6...
September 30, 2017: International Journal of Environmental Research and Public Health
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