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https://www.readbyqxmd.com/read/28202074/exendin-4-in-combination-with-adipose-derived-stem-cells-promotes-angiogenesis-and-improves-diabetic-wound-healing
#1
Eunhui Seo, Jae Soo Lim, Jin-Bum Jun, Woohyuk Choi, In-Sun Hong, Hee-Sook Jun
BACKGROUND: Diminished wound healing is a major complication of diabetes mellitus and can lead to foot ulcers. However, there are limited therapeutic methods to treat this condition. Exendin-4 (Ex-4), a glucagon-like peptide-1 receptor agonist, is known to have many beneficial effects on diabetes. In addition, mesenchymal stem cells are known to have wound healing effects. We investigated the effects of Ex-4 in combination with human adipose tissue-derived stem cells (ADSCs) on diabetic wound healing in a diabetic animal model...
February 15, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28198606/sustained-release-of-brimonidine-from-a-new-composite-drug-delivery-system-for-treatment-of-glaucoma
#2
Jianguo Sun, Yuan Lei, Zhaoxing Dai, Xi Liu, Taomin Huang, Jihong Wu, Zhi Ping Xu, Xinghuai Sun
A novel layered double hydroxide (LDH) nanoparticle/thermogel composite drug delivery system (DDS) for sustained release of brimonidine (Bri) has been designed, prepared and characterized in this study for treatment of severe glaucoma. Brimonidine is first loaded onto LDH (Bri@LDH) nanoparticles, which are then dispersed in the thermogel consisting of plenty of micelles based on poly-(DL-lactic acid co-glycolic acid)-polyethylene glycol-poly-(DL-lactic acid co-glycolic acid) (PLGA-PEG-PLGA) copolymer. The Bri@LDH/Thermogel DDS containing 125...
February 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28194759/association-of-peripheral-nk-cell-counts-with-helios-ifny-tregs-in-patients-with-good-long-term-renal-allograft-function
#3
Karina Trojan, Li Zhu, Mostafa Aly, Rolf Weimer, Nuray Bulut, Christian Morath, Gerhard Opelz, Volker Daniel
BACKGROUND: Little is known about a possible interaction of NK cells with Tregs in long-term stable kidney transplant recipients. METHODS: Absolute counts of lymphocyte and Treg subsets were studied in whole blood samples of 136 long-term stable renal transplant recipients and 52 healthy controls using eight-color-fluorescence flow cytometry. Patients were 1946±2201 days (153-10268 days) posttransplant and showed a serum creatinine of 1.7±0.7 mg/dl. RESULTS: Renal transplant recipients investigated >1...
February 14, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28181829/marked-augmentation-of-plga-nanoparticle-induced-metabolically-beneficial-impact-of-%C3%AE-oryzanol-on-fuel-dyshomeostasis-in-genetically-obese-diabetic-ob-ob-mice
#4
Chisayo Kozuka, Chigusa Shimizu-Okabe, Chitoshi Takayama, Kaku Nakano, Hidetaka Morinaga, Ayano Kinjo, Kotaro Fukuda, Asuka Kamei, Akihito Yasuoka, Takashi Kondo, Keiko Abe, Kensuke Egashira, Hiroaki Masuzaki
Our previous works demonstrated that brown rice-specific bioactive substance, γ-oryzanol acts as a chaperone, attenuates exaggerated endoplasmic reticulum (ER) stress in brain hypothalamus and pancreatic islets, thereby ameliorating metabolic derangement in high fat diet (HFD)-induced obese diabetic mice. However, extremely low absorption efficiency from intestine of γ-oryzanol is a tough obstacle for the clinical application. Therefore, in this study, to overcome extremely low bioavailability of γ-oryzanol with super-high lipophilicity, we encapsulated γ-oryzanol in polymer poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (Nano-Orz), and evaluated its metabolically beneficial impact in genetically obese-diabetic ob/ob mice, the best-known severest diabetic model in mice...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28181795/water-responsive-shape-recovery-induced-buckling-in-biodegradable-photo-cross-linked-poly-ethylene-glycol-peg-hydrogel
#5
Abhijit Vijay Salvekar, Wei Min Huang, Rui Xiao, Yee Shan Wong, Subbu S Venkatraman, Kiang Hiong Tay, Ze Xiang Shen
The phenomenon of recovering the permanent shape from a severely deformed temporary shape, but only in the presence of the right stimulus, is known as the shape memory effect (SME). Materials with such an interesting effect are known as shape memory materials (SMMs). Typical stimuli to trigger shape recovery include temperature (heating or cooling), chemical (including water/moisture and pH value), and light. As a SMM is able not only to maintain the temporary shape but also to respond to the right stimulus when it is applied, via shape-shifting, a seamless integration of sensing and actuation functions is achieved within one single piece of material...
February 9, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28179436/standardisation-and-application-of-the-single-breath-determination-of-nitric-oxide-uptake-in-the-lung
#6
Gerald S Zavorsky, Connie C W Hsia, J Michael B Hughes, Colin D R Borland, Hervé Guénard, Ivo van der Lee, Irene Steenbruggen, Robert Naeije, Jiguo Cao, Anh Tuan Dinh-Xuan
Diffusing capacity of the lung for nitric oxide (DLNO), otherwise known as the transfer factor, was first measured in 1983. This document standardises the technique and application of single-breath DLNO This panel agrees that 1) pulmonary function systems should allow for mixing and measurement of both nitric oxide (NO) and carbon monoxide (CO) gases directly from an inspiratory reservoir just before use, with expired concentrations measured from an alveolar "collection" or continuously sampled via rapid gas analysers; 2) breath-hold time should be 10 s with chemiluminescence NO analysers, or 4-6 s to accommodate the smaller detection range of the NO electrochemical cell; 3) inspired NO and oxygen concentrations should be 40-60 ppm and close to 21%, respectively; 4) the alveolar oxygen tension (PAO2 ) should be measured by sampling the expired gas; 5) a finite specific conductance in the blood for NO (θNO) should be assumed as 4...
February 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28177854/risk-factors-for-30-day-hospital-re-admission-with-an-infectious-complication-after-lower-extremity-vascular-procedures
#7
Joseph C Melvin, Jamie B Smith, Robin L Kruse, Todd R Vogel
BACKGROUND: Lowering the 30-d re-admission rate after vascular surgery offers the potential to improve healthcare quality. This study evaluated re-admission associated with infections after open and endovascular lower extremity (LE) procedures for peripheral artery disease (PAD). METHODS: Patients admitted for elective LE procedures for PAD were selected from the Cerner Health Facts(®) database. Chi-square analysis evaluated the characteristics of the index admission associated with infection at 30-d re-admission...
February 8, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28161517/profiles-of-polychlorinated-biphenyls-pcbs-in-cement-kilns-co-processing-solid-waste
#8
Rong Jin, Jiayu Zhan, Guorui Liu, Yuyang Zhao, Minghui Zheng, Lili Yang, Mei Wang
Co-incineration of sewage sludge in cement kilns can be used for its disposal. In the present study, samples were collected from three cement production runs where sewage sludge and other wastes (e.g. municipal solid waste, waste acid and wet sewage sludge) were co-processed. The samples were analyzed for polychlorinated biphenyls (PCBs). The dioxin-like (dl)-PCB concentrations in the stack gases from run 1, 2, and 3 were 344.6, 548.7, and 104.3 pg m(-3), respectively. The toxic equivalency (TEQs) values for runs 1, 2, and 3 were 5...
January 24, 2017: Chemosphere
https://www.readbyqxmd.com/read/28159399/particulate-and-gaseous-pollutants-on-inflammation-thrombosis-and-autonomic-imbalance-in-subjects-at-risk-for-cardiovascular-disease
#9
Szu-Ying Chen, Chang-Chuan Chan, Ta-Chen Su
This study examined effects of short-term urban air pollution exposures on inflammation, thrombosis, and autonomic imbalance in subjects at risk for cardiovascular disease (CVD). We enrolled 61 patients with multiple CVD risk factors and measured high sensitive C-reactive protein (hs-CRP), fibrinogen, D-dimer, and heart rate variability (HRV) indices. Two health examinations for each participant were performed during December 2002 through September 2003. Changes in inflammation and thrombotic markers and HRV indices with exposures to PM2...
January 31, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28123298/oxygen-and-indocyanine-green-loaded-phase-transition-nanoparticle-mediated-photo-sonodynamic-cytotoxic-effects-on-rheumatoid-arthritis-fibroblast-like-synoviocytes
#10
Qin Tang, Jianyu Cui, Zhonghua Tian, Jiangchuan Sun, Zhigang Wang, Shufang Chang, Shenyin Zhu
BACKGROUND: Photodynamic therapy and sonodynamic therapy are developing, minimally invasive, and site-specific modalities for cancer therapy. A combined strategy PSDT (photodynamic therapy followed by sonodynamic therapy) has been proposed in this study. Here, we aimed to develop novel biodegradable poly(DL-lactide-co-glycolic acid) phase-transition nanoparticles simultaneously loaded with oxygen and indocyanine green (OI-NPs) and to investigate the cytotoxic effects and the potential mechanisms of OI-NP-mediated PSDT on MH7A synoviocytes...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28119164/effect-of-the-dosage-ratio-and-the-viscosity-of-pac-pdmdaac-on-coagulation-performance-and-membrane-fouling-in-a-hybrid-coagulation-ultrafiltration-process
#11
Xue Shen, Baoyu Gao, Xin Huang, Fan Bu, Qinyan Yue, Ruihua Li, Bo Jin
This study systematically determined the optimal dosage ratio and the viscosity (η) of co-coagulants, polyaluminum chloride (PAC) and poly dimethyldiallylammonium chloride (PDMDAAC), on coagulation performance and membrane fouling in a hybrid coagulation-ultrafiltration (C-UF) process for natural organic matter (NOM) removal. Floc characteristics-including floc size, fractal dimension, strength and re-growth ability-were studied with respect to coagulant-dosing operations. Membrane fouling was evaluated in association with assessment of NOM removal performance by the hybrid process...
January 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28117739/affinin-spilanthol-isolated-from-heliopsis-longipes-induces-vasodilation-via-activation-of-gasotransmitters-and-prostacyclin-signaling-pathways
#12
Jesús Eduardo Castro-Ruiz, Alejandra Rojas-Molina, Francisco J Luna-Vázquez, Fausto Rivero-Cruz, Teresa García-Gasca, César Ibarra-Alvarado
Heliopsis longipes roots have been widely used in Mexican traditional medicine to relieve pain, mainly, toothaches. Previous studies have shown that affinin, the major alkamide of these roots, induces potent antinociceptive and anti-inflammatory activities. However, the effect of H. longipes root extracts and affinin on the cardiovascular system have not been investigated so far. In the present study, we demonstrated that the dichloromethane and ethanolic extracts of H. longipes roots, and affinin, isolated from these roots, produce a concentration-dependent vasodilation of rat aorta...
January 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28117361/the-impact-of-intragastric-balloons-on-obesity-related-co-morbidities-a-systematic-review-and-meta-analysis
#13
REVIEW
Violeta B Popov, Amy Ou, Allison R Schulman, Christopher C Thompson
ObjectivesTherapies less invasive than surgery and more effective than lifestyle and pharmacotherapy are needed to contend with the obesity epidemic. Intragastric balloons (IGBs) are a minimally invasive endoscopic weight loss method recently approved for use in the US. The purpose of the study is to assess the effect of IGBs on metabolic outcomes associated with obesity.MethodsMEDLINE, Embase, and Cochrane Database were searched through July 2016. Dual extraction and quality assessment of studies using Cochrane risk of bias tool were performed independently by two authors...
January 24, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28107673/mri-patterns-of-brain-injury-and-neurodevelopmental-outcomes-in-neonates-with-severe-anaemia-at-birth
#14
Begoña Loureiro, Miriam Martinez-Biarge, Francesca Foti, Maria Papadaki, Frances M Cowan, Courtney J Wusthoff
AIMS: To define patterns of brain injury and associated neurodevelopmental outcomes in infants with severe neonatal anaemia. METHODS: We studied 20 infants with severe anaemia at birth (haemoglobin<7g/dL). Clinical details were analysed for causes of anaemia and co-morbidities. All had early brain magnetic resonance imaging (MRI) scans, which were reviewed for injury pattern. Neurodevelopmental outcomes were assessed at a median age of 24months. RESULTS: The aetiology of the anaemia was feto-maternal haemorrhage in 17 and antepartum haemorrhage in 3 infants...
January 17, 2017: Early Human Development
https://www.readbyqxmd.com/read/28106356/accuracy-of-non-invasive-hemoglobin-monitoring-by-pulse-co-oximeter-during-liver-transplantation
#15
Gulay Erdogan Kayhan, Yusuf Z Colak, Mukadder Sanli, Muharrem Ucar, Huseyin I Toprak
BACKGROUND: Hemoglobin level monitoring is essential during liver transplantation (LT) due to substantial blood loss. We evaluated the accuracy of noninvasive and continuous hemoglobin monitoring (SpHb) obtained by a transcutaneous spectrophotometry-based technology (Masimo Corporation, Irvine, CA) compared with conventional laboratory Hb measurement (HbL) during LT. Additionally, we made subgroup analyses for distinct surgical phases that have special features and hemodynamic problems and thus may affect the accuracy of SpHb...
January 20, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28101358/novel-predictive-biomarkers-for-cervical-cancer-prognosis
#16
Pablo Moreno-Acosta, Schyrly Carrillo, Oscar Gamboa, Alfredo Romero-Rojas, Jinneth Acosta, Monica Molano, Joseph Balart-Serra, Martha Cotes, Chloé Rancoule, Nicolas Magné
High hypoxic, glycolytic and acidosis metabolisms characterize cervical cancer tumors and have been described to be involved in chemoradioresistance mechanisms. Based on these observations, the present study assessed four selected novel biomarkers on the prognosis of locally advanced cervical carcinoma. A total of 66 patients with stage IIB/IIIB cervical cancer were retrospectively included. The protein expression levels of glucose transporter 1 (GLUT1), carbonic anhydrase 9 (CAIX) and hexokinase 1 (HKII) were investigated by immunohistochemistry on tumor biopsies, hemoglobin was measured and the disease outcome was monitored...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28099134/carboxyhemoglobin-the-forgotten-parameter-of-neonatal-hyperbilirubinemia
#17
Douggl G N Bailey, Hans Fuchs, Roland Hentschel
BACKGROUND: Neonatal hyperbilirubinemia is influenced by a wide variety of factors, one of which is hemolysis. Serious hyperbilirubinemia may lead to a kernicterus with detrimental neurologic sequelae. Patients suffering from hemolytic disease have a higher risk of developing kernicterus. Carbon monoxide (CO), a byproduct of hemolysis or heme degradation, was described by Sjöstrand in the 1960s. It is transported as carboxyhemoglobin (COHb) and exhaled through the lungs. We were interested in a potential correlation between COHb and total serum bilirubin (TSB) and the time course of both parameters...
January 18, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28093368/surface-modification-of-pdllga-microspheres-with-gelatine-methacrylate-evaluation-of-adsorption-entrapment-and-oxygen-plasma-treatment-approaches
#18
Abdulrahman Baki, Cheryl V Rahman, Lisa J White, David J Scurr, Omar Qutachi, Kevin M Shakesheff
: Injectable poly (dl-lactic-co-glycolic acid) (PdlLGA) microspheres are promising candidates as biodegradable controlled release carriers for drug and cell delivery applications; however, they have limited functional groups on the surface to enable dense grafting of tissue specific biocompatible molecules. In this study we have evaluated surface adsorption, entrapment and oxygen plasma treatment as three approaches to modify the surfaces of PdlLGA microspheres with gelatine methacrylate (gel-MA) as a biocompatible and photo cross-linkable macromolecule...
January 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28092788/patient-level-meta-analysis-of-efficacy-and-hypoglycaemia-in-people-with-type-2-diabetes-initiating-insulin-glargine-100u-ml-or-neutral-protamine-hagedorn-insulin-analysed-according-to-concomitant-oral-antidiabetes-therapy
#19
David R Owens, Louise Traylor, Peter Mullins, Wolfgang Landgraf
AIMS: Evaluate efficacy and hypoglycaemia according to concomitant oral antidiabetes drug (OAD) in people with type 2 diabetes initiating insulin glargine 100U/mL (Gla-100) or neutral protamine Hagedorn (NPH) insulin once daily. METHODS: Four studies (target fasting plasma glucose [FPG] ⩽100mg/dL [⩽5.6mmol/L]; duration ⩾24weeks) were included. Standardised data from 2091 subjects (Gla-100, n=1024; NPH insulin, n=1067) were analysed. Endpoints included glycated haemoglobin (HbA1c) and FPG change, glycaemic target achievement, hypoglycaemia, weight change, and insulin dose...
November 9, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28088638/the-dlno-dlco-ratio-physiological-significance-and-clinical-implications
#20
J M B Hughes, A T Dinh-Xuan
DLNO/DLCO directly measures the ratio of the diffusing capacities of the lung for nitric oxide (NO) and carbon monoxide (CO). In terms of the Roughton and Forster (1957) equation, 1/DL=1/Dm+1/θVc, where Dm is the membrane (Dm) and θVc is the red cell component of the overall diffusing conductance (DL); DLNO mostly reflects the Dm component and DLCO the θVc red cell component. The DLNO/DLCO ratio is positively related to the DmCO/Vc ratio and the CO red cell resistance (1/θCOVc) as a percentage of the total resistance (1/DLCO), independent of the absolute values of DLNO or DLCO...
January 11, 2017: Respiratory Physiology & Neurobiology
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