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https://www.readbyqxmd.com/read/28107673/mri-patterns-of-brain-injury-and-neurodevelopmental-outcomes-in-neonates-with-severe-anaemia-at-birth
#1
Begoña Loureiro, Miriam Martinez-Biarge, Francesca Foti, Maria Papadaki, Frances M Cowan, Courtney J Wusthoff
AIMS: To define patterns of brain injury and associated neurodevelopmental outcomes in infants with severe neonatal anaemia. METHODS: We studied 20 infants with severe anaemia at birth (haemoglobin<7g/dL). Clinical details were analysed for causes of anaemia and co-morbidities. All had early brain magnetic resonance imaging (MRI) scans, which were reviewed for injury pattern. Neurodevelopmental outcomes were assessed at a median age of 24months. RESULTS: The aetiology of the anaemia was feto-maternal haemorrhage in 17 and antepartum haemorrhage in 3 infants...
January 17, 2017: Early Human Development
https://www.readbyqxmd.com/read/28106356/accuracy-of-non-invasive-hemoglobin-monitoring-by-pulse-co-oximeter-during-liver-transplantation
#2
Gulay Erdogan Kayhan, Yusuf Z Colak, Mukadder Sanli, Muharrem Ucar, Huseyin I Toprak
BACKGROUND: Hemoglobin level monitoring is essential during liver transplantation (LT) due to substantial blood loss. We evaluated the accuracy of noninvasive and continuous hemoglobin monitoring (SpHb) obtained by a transcutaneous spectrophotometry-based technology (Masimo Corporation, Irvine, CA) compared with conventional laboratory Hb measurement (HbL) during LT. Additionally, we made subgroup analyses for distinct surgical phases that have special features and hemodynamic problems and thus may affect the accuracy of SpHb...
January 20, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28101358/novel-predictive-biomarkers-for-cervical-cancer-prognosis
#3
Pablo Moreno-Acosta, Schyrly Carrillo, Oscar Gamboa, Alfredo Romero-Rojas, Jinneth Acosta, Monica Molano, Joseph Balart-Serra, Martha Cotes, Chloé Rancoule, Nicolas Magné
High hypoxic, glycolytic and acidosis metabolisms characterize cervical cancer tumors and have been described to be involved in chemoradioresistance mechanisms. Based on these observations, the present study assessed four selected novel biomarkers on the prognosis of locally advanced cervical carcinoma. A total of 66 patients with stage IIB/IIIB cervical cancer were retrospectively included. The protein expression levels of glucose transporter 1 (GLUT1), carbonic anhydrase 9 (CAIX) and hexokinase 1 (HKII) were investigated by immunohistochemistry on tumor biopsies, hemoglobin was measured and the disease outcome was monitored...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28099134/carboxyhemoglobin-the-forgotten-parameter-of-neonatal-hyperbilirubinemia
#4
Douggl G N Bailey, Hans Fuchs, Roland Hentschel
BACKGROUND: Neonatal hyperbilirubinemia is influenced by a wide variety of factors, one of which is hemolysis. Serious hyperbilirubinemia may lead to a kernicterus with detrimental neurologic sequelae. Patients suffering from hemolytic disease have a higher risk of developing kernicterus. Carbon monoxide (CO), a byproduct of hemolysis or heme degradation, was described by Sjöstrand in the 1960s. It is transported as carboxyhemoglobin (COHb) and exhaled through the lungs. We were interested in a potential correlation between COHb and total serum bilirubin (TSB) and the time course of both parameters...
January 18, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28093368/surface-modification-of-pdllga-microspheres-with-gelatine-methacrylate-evaluation-of-adsorption-entrapment-and-oxygen-plasma-treatment-approaches
#5
Abdulrahman Baki, Cheryl V Rahman, Lisa J White, David J Scurr, Omar Qutachi, Kevin M Shakesheff
: Injectable poly (DL-lactic-co-glycolic acid) (PDLLGA) microspheres are promising candidates as biodegradable controlled release carriers for drug and cell delivery applications; however, they have limited functional groups on the surface to enable dense grafting of tissue specific biocompatible molecules. In this study we have evaluated surface adsorption, entrapment and oxygen plasma treatment as three approaches to modify the surfaces of PDLLGA microspheres with gelatine methacrylate (gel-MA) as a biocompatible and photo cross-linkable macromolecule...
January 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28092788/patient-level-meta-analysis-of-efficacy-and-hypoglycaemia-in-people-with-type-2-diabetes-initiating-insulin-glargine-100u-ml-or-neutral-protamine-hagedorn-insulin-analysed-according-to-concomitant-oral-antidiabetes-therapy
#6
David R Owens, Louise Traylor, Peter Mullins, Wolfgang Landgraf
AIMS: Evaluate efficacy and hypoglycaemia according to concomitant oral antidiabetes drug (OAD) in people with type 2 diabetes initiating insulin glargine 100U/mL (Gla-100) or neutral protamine Hagedorn (NPH) insulin once daily. METHODS: Four studies (target fasting plasma glucose [FPG] ⩽100mg/dL [⩽5.6mmol/L]; duration ⩾24weeks) were included. Standardised data from 2091 subjects (Gla-100, n=1024; NPH insulin, n=1067) were analysed. Endpoints included glycated haemoglobin (HbA1c) and FPG change, glycaemic target achievement, hypoglycaemia, weight change, and insulin dose...
November 9, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28088638/the-dlno-dlco-ratio-physiological-significance-and-clinical-implications
#7
J M B Hughes, A T Dinh-Xuan
DLNO/DLCO directly measures the ratio of the diffusing capacities of the lung for nitric oxide (NO) and carbon monoxide (CO). In terms of the Roughton and Forster, 1957; equation, 1/DL=1/Dm+1/θVc, where Dm is the membrane (Dm) and θVc is the red cell component of the overall diffusing conductance (DL), DLNO mostly reflects the Dm component and DLCO the θVc red cell component. The DLNO/DLCO ratio is positively related to the DmCO/Vc ratio and the CO red cell resistance (1/θCOVc) as a percentage of the total resistance (1/DLCO), independent of the absolute values of DLNO or DLCO...
January 11, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28087341/lung-diffusing-capacity-in-sub-saharan-africans-versus-european-caucasians
#8
Bamodi Simaga, Kevin Forton, Yoshiki Motoji, Robert Naeije, Vitalie Faoro
Single breath measurements of lung diffusing capacity (DL) for carbon monoxide (CO) and nitric oxide (NO) were performed in age-, sex-, weight- and height-matched 32 Sub-Saharan Africans (13 women) and 32 Caucasian Europeans, and repeated in 14 of each group at 80% of maximum exercise capacity. In Africans versus Caucasians respectively, DLNO was 153±31 vs 176±38ml/mmHg/min at rest (P<0.001) and 210±48 vs 241±52ml/mmHg/min at exercise (P<0.01) while hemoglobin-adjusted DLCO was 29±6 vs 34±6ml/mmHg/min at rest (P<0...
January 10, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28070653/impact-of-acute-changes-in-perfusion-index-and-blood-pressure-on-the-accuracy-of-non-invasive-continuous-hemoglobin-concentration-measurements-during-induction-of-anesthesia
#9
Junichi Saito, Masato Kitayama, Erika Amanai, Kentaro Toyooka, Kazuyoshi Hirota
PURPOSE: Several factors affect the accuracy of non-invasive continuous hemoglobin concentration (SpHb) measurements. We had previously shown an increase in the perfusion index (PI) following induction of anesthesia which was associated with an increase in the difference between SpHb and total hemoglobin (tHb) (SpHb-tHb). We hypothesized that blunting the increase in PI by maintaining blood pressure during induction of anesthesia would improve the agreement between SpHb and tHb measurements...
January 9, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28064509/acute-salicylate-poisoning-risk-factors-for-severe-outcome
#10
Rachel M Shively, Robert S Hoffman, Alex F Manini
CONTEXT: Salicylate poisoning remains a significant public health threat with more than 20,000 exposures reported annually in the United States. OBJECTIVE: We aimed to establish early predictors of severe in-hospital outcomes in Emergency Department patients presenting with acute salicylate poisoning. METHODS: This was a secondary data analysis of adult salicylate overdoses from a prospective cohort study of acute drug overdoses at two urban university teaching hospitals from 2009 to 2013...
January 9, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28053522/do-nanoparticles-provide-a-new-opportunity-for-diagnosis-of-distal-airspace-disease
#11
Jakob Löndahl, Jonas Kf Jakobsson, David M Broday, H Laura Aaltonen, Per Wollmer
There is a need for efficient techniques to assess abnormalities in the peripheral regions of the lungs, for example, for diagnosis of pulmonary emphysema. Considerable scientific efforts have been directed toward measuring lung morphology by studying recovery of inhaled micron-sized aerosol particles (0.4-1.5 µm). In contrast, it is suggested that the recovery of inhaled airborne nanoparticles may be more useful for diagnosis. The objective of this work is to provide a theoretical background for the use of nanoparticles in measuring lung morphology and to assess their applicability based on a review of the literature...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28044372/psoriasis-and-metabolic-syndrome-in-children-current-data
#12
A Pietrzak, E Grywalska, M Walankiewicz, T Lotti, J Roliński, W Myśliński, P Chabros, D Piekarska-Myślińska, K Reich
BACKGROUND: The prevalence of cardiovascular and metabolic disorders in paediatric patients with psoriasis is not well established. AIM: To conduct a meta-analysis of previously published studies dealing with the occurrence of metabolic disorders in children with psoriasis. METHODS: Data from 7 studies with a total of 965 children with psoriasis were analysed using a random effects model. RESULTS: Prevalence of metabolic syndrome (MetS) was significantly higher in patients with psoriasis than in healthy controls (HCs)...
January 2, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28043815/associations-among-insulin-resistance-triacylglycerol-high-density-lipoprotein-tag-hdl-ratio-and-thyroid-hormone-levels-a-study-on-type-2-diabetes-mellitus-in-obese-and-overweight-subjects
#13
Rajendran Jayanthi, Abu Raghavan Srinivasan, Mohammed Hanifah, Anandraj Lokesh Maran
AIM: Triacylglycerol/High density lipoprotein (TAG/HDL) ratio, a surrogate marker of LDL particle size (small dense) was included in our study to observe the link with insulin resistance and thyroid co-morbidity. METHODS: Ninety three patients with T2DM of both genders were enrolled from a tertiary health care unit in Puducherry, during the latter half of 2015. The cardio-metabolic risk factors were assessed through body mass index (BMI), blood pressure, fasting blood glucose and lipid profile, glycated haemoglobin and homeostasis model assessment of insulin resistance (HOMA-IR)...
December 23, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28038752/enhancing-the-in-vitro-anticancer-activity-of-albendazole-incorporated-into-chitosan-coated-plga-nanoparticles
#14
Bong-Seok Kang, Jin-Seok Choi, Sang-Eun Lee, Joon-Kyung Lee, Tae-Hyeon Kim, Woo Suk Jang, Amolnat Tunsirikongkon, Jin-Ki Kim, Jeong-Sook Park
To improve the solubility and anticancer activity of albendazole (ABZ), chitosan (CS)-coated poly-dl-lactic-co-glycolic acid (PLGA) nanoparticles were developed. CS was used to coat ABZ-loaded PLGA nanoparticles to enhance both mucoadhesiveness and colloidal stability. CS-coated PLGA nanoparticles were prepared by suspending the nanoparticles in CS solution after solvent diffusion. The CS-coated PLGA nanoparticles were characterized, and ABZ release was studied in vitro from various formulations. The mucoadhesive properties and in vitro anticancer activities of CS-coated PLGA nanoparticles were investigated by measurement of zeta potentials and the MTT assay, respectively...
March 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28034464/noninvasive-hemoglobin-monitoring-in-critically-ill-pediatric-patients-at-risk-of-bleeding
#15
P García-Soler, J M Camacho Alonso, J M González-Gómez, G Milano-Manso
OBJECTIVE: To determine the accuracy and usefulness of noninvasive continuous hemoglobin (Hb) monitoring in critically ill patients at risk of bleeding. DESIGN: An observational prospective study was made, comparing core laboratory Hb measurement (LabHb) as the gold standard versus transcutaneous hemoglobin monitoring (SpHb). SETTING: Pediatric Intensive Care Unit of a tertiary University Hospital. PATIENTS: Patients weighing >3kg at risk of bleeding...
December 26, 2016: Medicina Intensiva
https://www.readbyqxmd.com/read/28025330/serum-calcium-and-risk-of-migraine-a-mendelian-randomization-study
#16
Peter Yin, Verneri Anttila, Katherine M Siewert, Aarno Palotie, George Davey Smith, Benjamin F Voight
Migraine affects ∼14% of the world's population, though not all predisposing causal risk factors are known. We used electronic health records, genetic co-heritability analysis, and a two-sample Mendelian Randomization (MR) design to determine if elevated serum calcium levels were associated with risk of migraine headache. Co-morbidity was evaluated using electronic health records obtained from the PennOmics database comprising >1 million patient entries. Genetic co-heritability and causality via MR was assessed using data from the International Headache Consortium (23,285 cases, 95,425 controls) and circulating serum calcium levels (39,400 subjects)...
December 26, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28024582/evaluation-of-poly-lactic-co-glycolic-acid-and-poly-dl-lactide-co-%C3%AE%C2%B5-caprolactone-electrospun-fibers-for-the-treatment-of-hsv-2-infection
#17
Stella E Aniagyei, Lee B Sims, Danial A Malik, Kevin M Tyo, Keegan C Curry, Woihwan Kim, Daniel A Hodge, Jinghua Duan, Jill M Steinbach-Rankins
More diverse multipurpose prevention technologies are urgently needed to provide localized, topical pre-exposure prophylaxis against sexually transmitted infections (STIs). In this work, we established the foundation for a multipurpose platform, in the form of polymeric electrospun fibers (EFs), to physicochemically treat herpes simplex virus 2 (HSV-2) infection. To initiate this study, we fabricated different formulations of poly(lactic-co-glycolic acid) (PLGA) and poly(dl-lactide-co-ε-caprolactone) (PLCL) EFs that encapsulate Acyclovir (ACV), to treat HSV-2 infection in vitro...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024570/visualization-of-silver-decorated-poly-dl-lactide-co-glycolide-nanoparticles-and-their-efficacy-against-staphylococcus-epidermidis
#18
Chisato Takahashi, Nobuhiro Matsubara, Yuki Akachi, Noriko Ogawa, Golap Kalita, Toru Asaka, Masaki Tanemura, Yoshiaki Kawashima, Hiromitsu Yamamoto
Understanding of self-protection activity of the bacteria and interaction with drug substances has significant importance for designing of effective drug delivery system for treatment of biofilm infections. Recently silver nanoparticle has attracted attention as antibacterial substance for drug delivery system because of its high antibacterial activity. Here, efflux of silver nanoparticles obtained from within the prepared silver-decorated poly (DL-lactide-co-glycolide) (Ag PLGA) nanoparticles derived from Staphylococcus epidermidis bacterial cell was successfully visualized using scanning transmission electron microscopy (STEM)...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28017301/prognostic-value-of-hypoalbuminemia-after-transcatheter-aortic-valve-implantation-from-the-japanese-multicenter-ocean-tavi-registry
#19
Masanori Yamamoto, Tetsuro Shimura, Seiji Kano, Ai Kagase, Atsuko Kodama, Mitsuru Sago, Tatsuya Tsunaki, Yutaka Koyama, Norio Tada, Futoshi Yamanaka, Toru Naganuma, Motoharu Araki, Shinichi Shirai, Yusuke Watanabe, Kentaro Hayashida
Hypoalbuminemia, a frailty criterion, belongs to a group of co-morbidities not captured as a traditional risk factor. We assessed its prognostic value in patients who underwent transcatheter aortic valve implantation (TAVI). The study included 1,215 consecutive patients from the Optimized Catheter Valvular Intervention -TAVI Japanese multicenter registry. Hypoalbuminemia was defined as serum albumin level <3.5 g/dl. Baseline characteristics, procedural outcomes, and all-cause, cardiovascular and noncardiovascular mortality rates after TAVI were compared between patients with albumin level <3...
December 2, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28007419/child-and-adult-exposure-and-health-risk-evaluation-following-the-use-of-metal-and-metalloid-containing-costume-cosmetics-sold-in-the-united-states
#20
Angela L Perez, Melanie Nembhard, Andrew Monnot, Daniel Bator, Elizabeth Madonick, Shannon H Gaffney
Costume cosmetics (lipstick, body paints, eyeshadow) were analyzed for metals using inductively coupled plasma mass spectrometry (ICP-MS). Sb was detected in all samples (range: 0.12-6.3 mg/kg; d.f. 100%), followed by Pb (<0.15-9.3 mg/kg), Ni (<0.20-6.3 mg/kg), Co (<0.5-2.0 mg/kg); with d.f. 80% each, Hg (<0.00015-0.0020 mg/kg; d.f. 50%) and As (0.53 mg/kg, d.f. 10%). Ingestion and dermal exposures were estimated for child- and adult-intermittent and adult-occupational users. Adult-occupational users exceeded the U...
December 19, 2016: Regulatory Toxicology and Pharmacology: RTP
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