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https://www.readbyqxmd.com/read/28434647/anemia-at-hospital-admission-and-its-relation-to-outcomes-in-patients-with-heart-failure-from-the-polish-cohort-of-2-european-society-of-cardiology-heart-failure-registries
#1
Agata Tymińska, Agnieszka Kapłon-Cieślicka, Krzysztof Ozierański, Michał Peller, Paweł Balsam, Michał Marchel, Maria G Crespo-Leiro, Aldo P Maggioni, Ewa A Jankowska, Jarosław Drożdż, Krzysztof J Filipiak, Grzegorz Opolski
Anemia is a commonly observed co-morbidity in heart failure (HF). The aim of the study was to assess prevalence, risk factors for, and effect of anemia on short- and long-term outcomes in HF. The study included 1,394 Caucasian patients hospitalized for HF, with known hemoglobin concentration on hospital admission, participating in 2 HF registries of the European Society of Cardiology (Pilot and Long-Term). Anemia was defined as hemoglobin concentration of <13 g/dl for men and <12 g/dl for women. Primary end points were (1) all-cause death at 1 year and (2) a composite of all-cause death and rehospitalization for HF at 1 year...
March 29, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28430010/prolonged-injectable-formulation-of-nafarelin-using-in-situ-gel-combination-delivery-system
#2
Behnoush Alizadeh, Nika Bahari Javan, Hamid Akbari Javar, Mohammad Reza Khoshayand, Farid Abedin Dorkoosh
The principal purpose of the present study was to prepare and characterize a complex drug delivery system consisting of Nafarelin- poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles (NPs) in combination with sodium alginate/poloxamer 407 in situ gel. Nafarelin loaded PHBV NPs were prepared via double emulsion solvent evaporation technique. Box-Behnken Response Surface Methodology was utilized to optimize NPs. Mean particle size, polydispersity index (PDI), entrapment efficiency (EE) and drug loading (DL) of the optimized NPs were measured...
April 21, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28407660/the-effects-of-calcium-vitamins-d-and-k-co-supplementation-on-markers-of-insulin-metabolism-and-lipid-profiles-in-vitamin-d-deficient-women-with-polycystic-ovary-syndrome
#3
Maryam Karamali, Mahnaz Ashrafi, Maryamalsadat Razavi, Mehri Jamilian, Maryam Kashanian, Maryam Akbari, Zatollah Asemi
Data on the effects of calcium, vitamins D and K co-supplementation on markers of insulin metabolism and lipid profiles among vitamin D-deficient women with polycystic ovary syndrome (PCOS) are scarce. This study was done to determine the effects of calcium, vitamins D and K co-supplementation on markers of insulin metabolism and lipid profiles in vitamin D-deficient women with PCOS. This randomized double-blind, placebo-controlled trial was conducted among 55 vitamin D-deficient women diagnosed with PCOS aged 18-40 years old...
April 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28402143/a-ph-independent-instantaneous-release-of-flurbiprofen-a-study-of-the-preparation-of-complexes-their-characterization-and-in-vitro-vivo-evaluation
#4
Han-Bing Wang, Fei-Fei Yang, Gai Xiu-Mei, Bing-Chao Cheng, Jin-Yu Li, Hao Pan, Xing-Gang Yang, Wei-San Pan
In this study, furbiprofen/hydroxypropyl-β-cyclodextrin (HPβCD) inclusion complexes were prepared to improve the drug dissolution and facilitate its application in hydrophilic gels. Inclusion complexes were prepared using a supercritical fluid (SCF) processing and a conventional optimized co-lypholization (OCL) method was employed as a reference. The entrapment efficacy (EE) and drug loading (DL) of both methods were investigated. Evaluation of drug dissolution enhancement was conducted in deionized water as well as buffer solutions of different pH...
April 12, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28399852/association-of-classical-markers-and-establishment-of-the-dyslipidemic-sub-phenotype-of-sickle-cell-anemia
#5
Milena Magalhães Aleluia, Caroline Conceição da Guarda, Rayra Pereira Santiago, Teresa Cristina Cardoso Fonseca, Fábia Idalina Neves, Regiana Quinto de Souza, Larissa Alves Farias, Felipe Araújo Pimenta, Luciana Magalhães Fiuza, Thassila Nogueira Pitanga, Júnia Raquel Dutra Ferreira, Elisângela Vitória Adorno, Bruno Antônio Veloso Cerqueira, Marilda de Souza Gonçalves
BACKGROUND: Sickle cell anemia (SCA) patients exhibit sub-phenotypes associated to hemolysis and vaso-occlusion. The disease has a chronic inflammatory nature that has been also associated to alterations in the lipid profile. This study aims to analyze hematological and biochemical parameters to provide knowledge about the SCA sub-phenotypes previously described and suggest a dyslipidemic sub-phenotype. METHODS: A cross-sectional study was conducted from 2013 to 2014, and 99 SCA patients in steady state were enrolled...
April 11, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28396088/erythrocyte-aging-as-a-mechanism-of-anemia-and-a-biomarker-of-device-thrombosis-in-continuous-flow-left-ventricular-assist-devices
#6
Ziad Taimeh, Ryan J Koene, Julie Furne, Ashish Singal, Peter M Eckman, Michael D Levitt, Marc R Pritzker
BACKGROUND: Blood trauma caused by continuous-flow left ventricular assist devices (CF-LVADs) has been associated with device thrombosis and anemia. Accurate in vivo quantification of erythrocyte turnover and its contribution to CF-LVAD complications have yet to be elucidated. METHODS: We investigated the age (lifespan) of circulating erythrocytes in subjects with CF-LVAD. Erythrocyte lifespan is a quantitative indicator of in vivo erythrocyte turnover that can be accurately derived from measurement of the exhaled carbon monoxide (CO) level...
February 9, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28395917/-compliance-with-recommendations-in-secondary-prevention-of-stroke-in-primary-care
#7
Carmen Tamayo-Ojeda, Neus Parellada-Esquius, Betlem Salvador-González, Pilar Ángeles Oriol-Torón, M Dolores Rodríguez-Garrido, Dolores Muñoz-Segura
OBJECTIVE: Knowing compliance with secondary prevention recommendations of stroke in primary care and to identify factors associated with compliance. DESIGN: Multi-centre cross-sectional. SETTING: Health primary care centres in a metropolitan area (944,280 inhabitants). PARTICIPANTS: Patients aged 18years and over with ischemic brain disease diagnosis prior to 6months before the study. MAIN MEASUREMENTS: Clinical history records of demographic variables, risk factors and cardiovascular comorbidity, drugs, blood pressure values (BP), LDL-cholesterol and medical visits by doctor and nurses after the event...
April 7, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28393518/enhancing-vascularization-through-the-controlled-release-of-platelet-derived-growth-factor-bb
#8
Silvia Minardi, Laura Pandolfi, Francesca Taraballi, Xin Wang, Enrica De Rosa, Zachary D Mills, Xuewu Liu, Mauro Ferrari, Ennio Tasciotti
Using delivery systems to control the in vivo release of growth factors (GFs) for tissue engineering applications is extremely desirable as the clinical use of GFs is limited by their fast in vivo turnover. Hence, the development of effective platforms that are able to finely control the release of GFs in vivo remains a challenge. Herein, we investigated the ability of multiscale microspheres, composed by a nanostructured silicon multistage vector (MSV) core and a poly(dl-lactide-co-glycolide) acid (PLGA) forming outer shell (PLGA-MSV), to release functional platelet-derived growth factor-BB (PDGF-BB) to induce in vivo localized neovascularization...
April 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28391082/estradiol-loaded-plga-nanoparticles-for-improving-low-bone-mineral-density-of-cancellous-bone-caused-by-osteoporosis-application-of-enhanced-charged-nanoparticles-with-iontophoresis
#9
Issei Takeuchi, Shiori Kobayashi, Yukari Hida, Kimiko Makino
Postmenopausal osteoporosis among older women, which occurs by an ovarian hormone deficiency, is one of the major public health problems. 17 β-estradiol (E2) is used to prevent and treat this disease as a drug of hormone replacement therapy. In oral administration, E2 is significantly affected by first-pass hepatic metabolism, and high dose administration must be needed to obtain drug efficacy. Therefore, alternative administration route is needed, and we have focused on the transdermal drug delivery system...
March 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28374963/mortality-caused-by-intracranial-bleeding-in-non-severe-hemophilia-a-patients
#10
Janneke I Loomans, Corien L Eckhardt, Sylvia E Reitter-Pfoertner, Margareta Holmström, Britta Laros van Gorkom, Frank W G Leebeek, Cristina Santoro, Saturnino Haya, Karina Meijer, Marten R Nijziel, Johanna G Van der Bom, Karin Fijnvandraat
INTRODUCTION: Non-severe hemophilia (factor VIII concentration (FVIII:C) 2-40 IU/dL) is characterized by a milder bleeding phenotype than severe hemophilia A. However, some patients with non-severe hemophilia A suffer from severe bleeding complications that may result in death. Data on bleeding-related causes of death, such as fatal intracranial bleeding in non-severe patients are scarce. Such data may provide new insight in areas of care that can be improved. AIMS: To describe mortality rates, risk factors and co-morbidities associated with fatal intracranial bleeding in non-severe hemophilia A patients...
April 4, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28371205/efficacy-and-safety-of-tofogliflozin-in-japanese-patients-with-type-2-diabetes-mellitus-with-inadequate-glycaemic-control-on-insulin-therapy-j-step-ins-results-of-a-16-week-randomized-double-blind-placebo-controlled-multicentre-trial
#11
Yasuo Terauchi, Masahiro Tamura, Masayuki Senda, Ryoji Gunji, Kohei Kaku
AIMS: To assess the effects of 16 weeks of tofogliflozin (sodium/glucose co-transporter 2 (SGLT2) inhibitor) treatment versus placebo on glycosylated haemoglobin (HbA1c) levels in Japanese patients with type 2 diabetes mellitus (T2DM) inadequately controlled with insulin monotherapy or insulin plus a dipeptidyl peptidase-4 (DPP-4) inhibitor. METHODS: This study comprises a 16-week, multicentre, double-blind, placebo-controlled period and a 36-week extension (NCT02201004)...
March 30, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28356090/anca-vasculitis-in-a-patient-with-alport-syndrome-a-difficult-diagnosis-but-a-treatable-disease
#12
Valentine Gillion, Michel Jadoul, Selda Aydin, Nathalie Godefroid
BACKGROUND: Alport syndrome and ANCA-associated vasculitis are both rare diseases. The co-existence of these two conditions has never been reported. There is no obvious pathogenic link between these two glomerular diseases. The management of this case highlights the importance of a systematic approach when investigating the unexpected unfavourable evolution of a known glomerulopathy. CASE PRESENTATION: A-17 year old caucasian boy with a genetically proven X-linked Alport syndrome presented with progressive dyspnea, fatigue and pallor...
March 29, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28355256/the-usefulness-of-monomeric-periostin-as-a-biomarker-for-idiopathic-pulmonary-fibrosis
#13
Shoichiro Ohta, Masaki Okamoto, Kiminori Fujimoto, Noriho Sakamoto, Koichiro Takahashi, Hiroshi Yamamoto, Hisako Kushima, Hiroshi Ishii, Keiichi Akasaka, Junya Ono, Ayami Kamei, Yoshinori Azuma, Hisako Matsumoto, Yukie Yamaguchi, Michiko Aihara, Takeshi Johkoh, Atsushi Kawaguchi, Masao Ichiki, Hironori Sagara, Jun-Ichi Kadota, Masayuki Hanaoka, Shin-Ichiro Hayashi, Shigeru Kohno, Tomoaki Hoshino, Kenji Izuhara
The natural course of idiopathic pulmonary fibrosis (IPF) is variable. Predicting disease progression and survival in IPF is important for treatment. We previously demonstrated that serum periostin has the potential to be a prognostic biomarker for IPF. Our aim was to use monomeric periostin in a multicenter study to evaluate its efficacy in diagnosing IPF and predicting its progression. To do so, we developed a new periostin kit to detect only monomeric periostin. The subjects consisted of 60 IPF patients in a multicenter cohort study...
2017: PloS One
https://www.readbyqxmd.com/read/28335545/reference-values-of-14-serum-trace-elements-for-pregnant-chinese-women-a-cross-sectional-study-in-the-china-nutrition-and-health-survey-2010-2012
#14
Xiaobing Liu, Yu Zhang, Jianhua Piao, Deqian Mao, Yajie Li, Weidong Li, Lichen Yang, Xiaoguang Yang
The development of reference values of trace elements is recognized as a fundamental prerequisite for the assessment of trace element nutritional status and health risks. In this study, a total of 1400 pregnant women aged 27.0 ± 4.5 years were randomly selected from the China Nutrition and Health Survey 2010-2012 (CNHS 2010-2012). The concentrations of 14 serum trace elements were determined by high-resolution inductively coupled plasma mass spectrometry. Reference values were calculated covering the central 95% reference intervals (P2...
March 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28323203/the-association-between-cardiorespiratory-fitness-and-pulmonary-diffusing-capacity
#15
Gerald S Zavorsky, James M Smoliga
Pulmonary diffusing capacity for nitric oxide (DL,NO) and carbon monoxide (DL,CO) measured at rest (mL/min/mmHg) is strongly associated with aerobic capacity (cardiorespiratory fitness or peak oxygen uptake, VO2peak) measured in L/min. Data from healthy, non-obese individuals from various studies (n=121 males and 81 females) were combined to examine this association. Subjects that were above the upper limit of normal (ULN, 97.5th percentile for age and sex and height) for DL,NO and DLCO had a higher median VO2peak compared to subjects below the ULN (Above the ULN=4...
March 18, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28302078/early-serum-creatinine-accurately-predicts-acute-kidney-injury-post-cardiac-surgery
#16
Keren Grynberg, Kevan R Polkinghorne, Sharon Ford, Fiona Stenning, Thomas E Lew, Jonathan A Barrett, Shaun A Summers
BACKGROUND: Acute Kidney Injury (AKI) is a well recognized complication of cardiac surgery. It is associated with significant morbidity and mortality. The aims of our study are twofold; 1. To define the incidence of AKI post cardiac surgery. 2. To identify pre-morbid and operative risk factors for developing AKI and to determine if immediate post operative serum creatinine (IPOsCr) accurately predicts the development of AKI. METHODS: We prospectively studied 196 consecutive patients undergoing elective (on-pump) cardiac surgery...
March 16, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28302065/lamivudine-dolutegravir-dual-therapy-in-hiv-infected-virologically-suppressed-patients
#17
Franco Maggiolo, Roberto Gulminetti, Layla Pagnucco, Margherita Digaetano, Simone Benatti, Daniela Valenti, Annapaola Callegaro, Diego Ripamonti, Cristina Mussini
BACKGROUND: Little is known about the applicability of dual treatments based on integrase inhibitors. We explored the combination of lamivudine + dolutegravir as an option when switching from standard cART in virologically suppressed patients. METHODS: In this prospective cohort we enrolled patients previously switched to 3TC + DTG who were 18 years or older, with no previous resistance mutations to the used drugs, having a HIV-RNA <50 copies/ml for 6 months or longer, negative for HBsAg and on a stable (>6 months) cART...
March 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28275387/a-case-of-isolated-glycosuria-mediated-by-an-slc5a2-gene-mutation-and-characterized-by-postprandial-heavy-glycosuria-without-salt-wasting
#18
Kyeong Min Kim, Soon Kil Kwon, Hye-Young Kim
Familial renal glycosuria (FRG) is an inherited disorder characterized by persistent glycosuria in the absence of hyperglycemia. It is caused by mutations in the sodium-glucose co-transporter, leading to increase in the renal excretion of glucose and sodium. However, there have been no studies on the role of fasting and postprandial changes in the urinary sodium excretion in patients with FRG. We report a case of renal glycosuria, which was confirmed by a SLC5A2 mutation via gene sequencing, and compared the postprandial urinary glucose and sodium excretion...
December 2016: Electrolyte & Blood Pressure: E & BP
https://www.readbyqxmd.com/read/28263822/low-testosterone-levels-result-in-decreased-periurethral-vascularity-via-an-androgen-receptor-mediated-process-pilot-study-in-urethral-stricture-tissue
#19
Matthias D Hofer, Payal Kapur, Billy H Cordon, Farrah Hamoun, David Russell, Jeremy M Scott, Claus G Roehrborn, Allen F Morey
OBJECTIVE: To compare expression of androgen receptor (AR) and angiopoietin 1 receptor TIE-2 and vessel density of urethral stricture tissue among eugonadal and hypogonadal men to identify a pathophysiological basis for our observations that low testosterone is associated with urethral atrophy. METHODS: Among 1200 men having urethroplasty at our institution, we retrospectively identified 11 patients with testosterone levels drawn within 2 years of surgery. Low testosterone was defined as <280 ng/dL and detected in 5 of 11 (45...
March 2, 2017: Urology
https://www.readbyqxmd.com/read/28259944/ursolic-acid-nanoparticles-inhibit-cervical-cancer-growth-in-vitro-and-in-vivo-via-apoptosis-induction
#20
Shaoguang Wang, Xiaomei Meng, Yaozhong Dong
Cervical cancer is a cause of cancer death, making it one of the most common causes of death among women globally. Previously, a variety of studies have revealed the molecular mechanisms by which cervical cancer develops. However, there are still limitations in treatment for cervical cancer. Ursolic acid is a naturally derived pentacyclic triterpene acid, exhibiting broad anticancer effects. Nanoparticulate drug delivery systems have been known to better the bioavailability of drugs on intranasal administration compared with only drug solutions...
February 22, 2017: International Journal of Oncology
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