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carbon monoxide diffusing capacity of the lungs

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https://www.readbyqxmd.com/read/28915226/pulmonary-vascular-function-and-aerobic-exercise-capacity-at-moderate-altitude
#1
Vitalie Faoro, Gael Deboeck, Marco Vicenzi, Anne-Fleur Gaston, Bamodi Simaga, Grégory Doucende, Ilona Hapkova, Emma Roca, Enric Subirats, Fabienne Durand, Robert Naeije
PURPOSE: There has been suggestion that a greater "pulmonary vascular reserve" defined by a low pulmonary vascular resistance (PVR) and a high lung diffusing capacity (DL) allow for a superior aerobic exercise capacity. How pulmonary vascular reserve might affect exercise capacity at moderate altitude is not known. METHODS: Thirty-eight healthy subjects underwent an exercise stress echocardiography of the pulmonary circulation, combined with measurements of DL for nitric oxide (NO) and carbon monoxide (CO) and a cardiopulmonary exercise test at sea level and at an altitude of 2250 m...
October 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28906550/efficacy-and-safety-of-autologous-haematopoietic-stem-cell-transplantation-in-systemic-sclerosis-a-systematic-review-of-literature
#2
A Eyraud, L Scouppe, T Barnetche, E Forcade, E Lazaro, P Duffau, C Richez, J Seneschal, M-E Truchetet
We aimed at assessing the efficacy of autologous haematopoietic stem cell transplantation (HSCT) for skin sclerosis and lung function in systemic sclerosis (SSc). We performed a systematic literature review in the Pubmed and Scopus databases from the earliest records to March 2016. We assessed quality using the Cochrane tool for randomized studies, Newcastle-Ottawa scale for controlled-cohort studies and an 18-item quality appraisal checklist for case series. The primary outcome was the improvement of skin thickening using the modified Rodnan Skin Score (mRSS)...
September 14, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28883926/clinical-use-of-nintedanib-in-patients-with-idiopathic-pulmonary-fibrosis
#3
REVIEW
Amy Hajari Case, Peace Johnson
Idiopathic pulmonary fibrosis (IPF) is a rare lung disease characterised by progressive loss of lung function, dyspnoea and cough. IPF has a variable clinical course but a poor prognosis. Nintedanib, a tyrosine kinase inhibitor, is one of two drugs approved for the treatment of IPF. In clinical trials, nintedanib slowed disease progression by reducing the rate of decline in forced vital capacity (FVC) in patients with IPF and mild or moderate lung function impairment. The effect of nintedanib was consistent across patient subgroups defined by baseline characteristics including FVC % predicted, diffusion capacity of the lung for carbon monoxide % predicted and the presence of emphysema...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28877978/how-i-manage-pulmonary-langerhans-cell-histiocytosis
#4
Gwenaël Lorillon, Abdellatif Tazi
Pulmonary Langerhans cell histiocytosis (PLCH) is a rare sporadic cystic lung disease of unknown aetiology that is characterised by the infiltration and destruction of the wall of distal bronchioles by CD1a(+) Langerhans-like cells. In adults, PLCH is frequently isolated and affects young smokers of both sexes. Recent multicentre studies have led to the more standardised management of patients in clinical practice. Smoking cessation is essential and is occasionally the only suitable intervention. Serial lung function testing is important because a significant proportion of patients may experience an early decline in forced expiratory volume in 1 s and develop airflow obstruction...
September 30, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28876128/influence-of-inhaled-amiloride-on-lung-fluid-clearance-in-response-to-normobaric-hypoxia-in-healthy-individuals
#5
Courtney M Wheatley, Sarah E Baker, Bryan J Taylor, Manda L Keller-Ross, Steven C Chase, Alex R Carlson, Robert J Wentz, Eric M Snyder, Bruce D Johnson
Wheatley, Courtney M., Sarah E. Baker, Bryan J. Taylor, Manda L. Keller-Ross, Steven C. Chase, Alex R. Carlson, Robert J. Wentz, Eric M. Snyder, and Bruce D. Johnson. Influence of inhaled amiloride on lung fluid clearance in response to normobaric hypoxia in healthy individuals. High Alt Med Biol 00:000-000, 2017. AIM: To investigate the role of epithelial sodium channels (ENaC) on lung fluid clearance in response to normobaric hypoxia, 20 healthy subjects were exposed to 15 hours of hypoxia (fraction of inspired oxygen [FiO2] = 12...
September 6, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28875146/importance-of-serial-changes-in-biomarkers-in-idiopathic-pulmonary-fibrosis
#6
Akihiko Sokai, Kiminobu Tanizawa, Tomohiro Handa, Kumiko Kanatani, Takeshi Kubo, Kohei Ikezoe, Yoshinari Nakatsuka, Shinsaku Tokuda, Toru Oga, Toyohiro Hirai, Sonoko Nagai, Kazuo Chin, Michiaki Mishima
The clinical significance of serial changes in serum biomarkers in patients with idiopathic pulmonary fibrosis (IPF) remains to be established. This retrospective study was conducted to clarify the associations of serial changes in serum Krebs von den Lungen-6 (KL-6) and surfactant protein-D (SP-D) with changes in physiological indices and overall mortality in IPF. The study subjects were 75 patients with IPF. The 6 month change in serum KL-6 was significantly correlated with changes in the percentage of the predicted forced vital capacity (FVC % pred) and the percentage of the predicted diffusing capacity of the lung for carbon monoxide (% DLCO), while the 6 month change in serum SP-D was correlated only with % DLCO...
July 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28871983/phase-1-2-study-of-dual-energy-computed-tomography-for-assessment-of-pulmonary-function-in-radiation-therapy-planning
#7
Houda Bahig, Marie-Pierre Campeau, Andréanne Lapointe, Stephane Bedwani, David Roberge, Jacques de Guise, Danis Blais, Toni Vu, Louise Lambert, Carl Chartrand-Lefebvre, Martin Lord, Edith Filion
PURPOSE: To quantify lung function according to a dual-energy computed tomography (DECT)-derived iodine map in patients treated with radiation therapy for lung cancer, and to assess the dosimetric impact of its integration in radiation therapy planning. METHODS AND MATERIALS: Patients treated with stereotactic ablative radiation therapy for early-stage or intensity modulated radiation therapy for locally advanced lung cancer were prospectively enrolled in this study...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28867545/never-too-old-a-single-institution-experience-of-stereotactic-body-radiation-therapy-for-patients-90-years-and-older-with-early-stage-lung-cancer
#8
Gregory M M Videtic, Neil M Woody, Chandana A Reddy, Kevin L Stephans
PURPOSE: To report on the patient, tumor, and treatment characteristics of patients aged 90 years or older who were treated with lung stereotactic body radiation therapy (SBRT) for early stage lung cancer and the resulting clinical outcomes. METHODS AND MATERIALS: We surveyed our institutional review board-approved prospective lung SBRT data registry for patients aged 90 years or older who were treated for early stage lung cancer to determine the rates of local failure, progression-free survival, and overall survival as well as treatment-related toxicity...
June 29, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28860741/comparison-of-world-health-organization-and-asia-pacific-body-mass-index-classifications-in-copd-patients
#9
Jeong Uk Lim, Jae Ha Lee, Ju Sang Kim, Yong Il Hwang, Tae-Hyung Kim, Seong Yong Lim, Kwang Ha Yoo, Ki-Suck Jung, Young Kyoon Kim, Chin Kook Rhee
INTRODUCTION: A low body mass index (BMI) is associated with increased mortality and low health-related quality of life in patients with COPD. The Asia-Pacific classification of BMI has a lower cutoff for overweight and obese categories compared to the World Health Organization (WHO) classification. The present study assessed patients with COPD among different BMI categories according to two BMI classification systems: WHO and Asia-Pacific. PATIENTS AND METHODS: Patients with COPD aged 40 years or older from the Korean COPD Subtype Study cohort were selected for evaluation...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28860333/using-hyperpolarized-129-xe-mri-to-quantify-regional-gas-transfer-in-idiopathic-pulmonary-fibrosis
#10
Jennifer M Wang, Scott H Robertson, Ziyi Wang, Mu He, Rohan S Virgincar, Geoffry M Schrank, Rose Marie Smigla, Thomas G O'Riordan, John Sundy, Lukas Ebner, Craig R Rackley, Page McAdams, Bastiaan Driehuys
BACKGROUND: Assessing functional impairment, therapeutic response and disease progression in patients with idiopathic pulmonary fibrosis (IPF) continues to be challenging. Hyperpolarized (129)Xe MRI can address this gap through its unique capability to image gas transfer three-dimensionally from airspaces to interstitial barrier tissues to red blood cells (RBCs). This must be validated by testing the degree to which it correlates with pulmonary function tests (PFTs) and CT scores, and its spatial distribution reflects known physiology and patterns of disease...
August 31, 2017: Thorax
https://www.readbyqxmd.com/read/28855034/-clinical-characteristics-of-118-cases-of-chronic-obstructive-pulmonary-disease-complicated-with-primary-bronchopulmonary-carcinoma
#11
Songlin Zhao, Xiuhong Nie, Lin Zhang, Wei Zhang, Han Xiao
BACKGROUND: The aim of this study is to investigate the clinical characteristics of patients with primary bronchopulmonary carcinoma complicated with chronic obstructive pulmonary disease (COPD), and to optimize the early diagnoses in the coexistence of COPD and primary bronchopulmonary carcinoma. METHODS: The clinical data of 118 patients with COPD complicated with primary bronchopulmonary carcinoma were analyzed retrospectively, including age, sex, smoking history, smoking index, clinical symptoms and signs, pathological type, staging, metastasis site and lung function index...
August 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28841877/influence-of-resting-lung-diffusion-on-exercise-capacity-in-patients-with-copd
#12
Mehrdad Behnia, Courtney Wheatley, Alberto Avolio, Bruce Johnson
BACKGROUND: Lung diffusing capacity for carbon monoxide (DLCO) gives an overall assessment of functional lung surface area for gas exchange and can be assessed using various methods. DLCO is an important factor in exercise intolerance in patients with chronic obstructive pulmonary disease (COPD). We investigated if the intra-breath (IBDLCO) method may give a more sensitive measure of available gas exchange surface area than the more typical single breath (SBDLCO) method and if COPD subjects with the largest resting DLCO relative to pulmonary blood flow (Qc) would have a more preserved exercise capacity...
August 25, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28808493/pulmonary-consequences-of-hypothyroidism
#13
Samiaa Hamdy Sadek, Walaa Anwar Khalifa, Ahmad Metwally Azoz
BACKGROUND: Although hypothyroidism has an insidious onset and relatively asymptomatic, exertional dyspnea and fatigue can be the presenting complaints. OBJECTIVES: The aim is to assess functional lung impairment in hypothyroid patients both at rest and during exercise. METHODS: A case-control study was carried out on 42 patients with newly diagnosed hypothyroidism and 12 control subjects. Hypothyroidism was diagnosed based on high value of thyroid stimulating hormone (TSH) ≥6 μIU/ml, and low value of free thyroxin (FT4) ≤0...
July 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/28807589/differences-in-texture-analysis-parameters-between-active-alveolitis-and-lung-fibrosis-in-chest-ct-of-patients-with-systemic-sclerosis-a-feasibility-study
#14
Christopher Kloth, Anya C Blum, Wolfgang M Thaiss, Heike Preibsch, Hendrik Ditt, Rainer Grimmer, Jan Fritz, Konstantin Nikolaou, Hans Bösmüller, Marius Horger
RATIONALE AND OBJECTIVES: This study aimed to determine the diagnostic aid of computed tomography (CT) features for the differentiation of active alveolitis and fibrosis using a CT texture analysis (CTTA) prototype and CT densitometry in patients with systemic sclerosis (SSc) using ancillary high-resolution computed tomography (HRCT) features and their longitudinal course as standard of reference. MATERIALS AND METHODS: We retrospectively analyzed thin-slice noncontrast chest CT image data of 43 patients with SSc (18 men, mean age 51...
August 11, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28805996/what-can-we-learn-from-pulmonary-function-testing-in-heart-failure
#15
REVIEW
Helgo Magnussen, Marco Canepa, Peter Emilio Zambito, Vito Brusasco, Thomas Meinertz, Stephan Rosenkranz
Pulmonary diseases frequently coexist in heart failure (HF), thus posing diagnostic and therapeutic challenges to cardiologists evaluating patients with overlapping symptoms and implementing recommended HF treatments. There is a growing body of evidence suggesting that pulmonary function testing might provide useful information for the best management of these patients. The availability of portable devices, allowing the measurement of spirometry and lung diffusion capacity for carbon monoxide outside of hospital-based pulmonary lung function laboratories, provides an opportunity for a more widespread use of these measures in the cardiology community, but their interpretation can be challenging...
August 14, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28804812/predominance-of-comorbidities-in-the-detriment-of-daily-activity-in-sarcoidosis-patients
#16
S Kostorz, D Jastrzębski, M Sikora, A Zebrowska, A Margas, D Stepanik, H Swinder, D Ziora
Sarcoidosis may affect lung function, working ability, overall mobility, and daily activity. In the present study we performed an analysis of clinical settings in patients with sarcoidosis to disentangle its influence on daily physical activity (PA). PA assessment (number of steps per day, daily energy expenditure) was performed by accelerometry during consecutive 7 days after discharge from hospital. Thirty patients with sarcoidosis, aged 46.4 ± 10.5, were enrolled in the study. Clinical data (age, gender, steroid consumption, weight, and comorbidities), lung function tests (forced expiratory volume in one second - FEV1, forced vital capacity - FVC, and lung diffusion for carbon monoxide - DLCO), mobility (6-minute walk test- 6MWT) and physical performance (oxygen consumption at anaerobic threshold - VO2/AT) were estimated...
August 15, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28782791/occupational-exposures-to-solvents-and-metals-are-associated-with-fixed-airflow-obstruction
#17
Sheikh M Alif, Shyamali C Dharmage, Geza Benke, Martine Dennekamp, Jennifer L Burgess, Caroline J Lodge, Stephen Morrison, David P Johns, Graham G Giles, Lyle C Gurrin, Paul S Thomas, John L Hopper, Richard Wood-Baker, Bruce R Thompson, Iain H Feather, Roel Vermeulen, Hans Kromhout, E Haydn Walters, Michael J Abramson, Melanie C Matheson
Objectives This study investigated the associations between occupational exposures to solvents and metals and fixed airflow obstruction (AO) using post-bronchodilator spirometry. Methods We included 1335 participants from the 2002-2008 follow-up of the Tasmanian Longitudinal Health Study. Ever-exposure and cumulative exposure-unit (EU) years were calculated using the ALOHA plus job exposure matrix (JEM). Fixed AO was defined as post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) <0...
August 7, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/28763468/predictors-of-lung-function-test-severity-and-outcome-in-systemic-sclerosis-associated-interstitial-lung-disease
#18
Noémie Le Gouellec, Alain Duhamel, Thierry Perez, Anne-Lise Hachulla, Vincent Sobanski, Jean-Baptiste Faivre, Sandrine Morell-Dubois, Marc Lambert, Pierre-Yves Hatron, Eric Hachulla, Hélène Béhal, Regis Matran, David Launay, Martine Remy-Jardin
Systemic sclerosis-related interstitial lung disease (SSc-ILD) is the leading cause of death in SSc. In this study, we aimed to describe the baseline severity and evolution of forced vital capacity (FVC) and diffusing capacity for carbon monoxide (DLCO) in patients with SSc-ILD and to assess the baseline clinical, biological and high-resolution CT scan (HRCT) predictors of this evolution. Baseline and serial FVC and DLCO were collected in 75 SSc-ILD patients followed during 6.4±4.2 years (n = 557 individual data)...
2017: PloS One
https://www.readbyqxmd.com/read/28761337/size-variation-and-collapse-of-emphysema-holes-at-inspiration-and-expiration-ct-scan-evaluation-with-modified-length-scale-method-and-image-co-registration
#19
Sang Young Oh, Minho Lee, Joon Beom Seo, Namkug Kim, Sang Min Lee, Jae Seung Lee, Yeon Mok Oh
A novel approach of size-based emphysema clustering has been developed, and the size variation and collapse of holes in emphysema clusters are evaluated at inspiratory and expiratory computed tomography (CT). Thirty patients were visually evaluated for the size-based emphysema clustering technique and a total of 72 patients were evaluated for analyzing collapse of the emphysema hole in this study. A new approach for the size differentiation of emphysema holes was developed using the length scale, Gaussian low-pass filtering, and iteration approach...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28758849/clinical-profile-of-unclassifiable-interstitial-lung-disease-comparison-with-chronic-fibrosing-idiopathic-interstitial-pneumonias
#20
Daniel Traila, Cristian Oancea, Emanuela Tudorache, Ovidiu Fira Mladinescu, Bogdan Timar, Voicu Tudorache
Objective Unclassifiable interstitial lung disease (ILD) is a common problem in clinical practice. These patients pose a distinct challenge with regard to appropriate evaluation and management. We investigated the clinical features and prognosis of unclassifiable ILD and compared its clinical profile with that of idiopathic pulmonary fibrosis (IPF) and idiopathic nonspecific interstitial pneumonia (NSIP). Methods Patients with IPF (n = 40), NSIP (n = 14), and unclassifiable ILD (n = 27) were selected from an ongoing database...
January 1, 2017: Journal of International Medical Research
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