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https://www.readbyqxmd.com/read/29649257/an-experimental-staphylococcus-aureus-carriage-and-decolonization-model-in-rhesus-macaques-macaca-mulatta
#1
Bibi C G C Slingerland, Merei Keehnen, Boudewijn Ouwerling, Mehri Tavakol, Susan V Snijders, Henri A Verbrugh, Margreet C Vos, Edmond J Remarque, Jan A M Langermans, Willem J B van Wamel
Our human model of nasal colonization and eradication of S. aureus is limited by safety issues. As rhesus macaques are closely related to humans and natural hosts for S. aureus, we developed an experimental decolonization and inoculation protocol in these animals. Animals were screened for nasal carriage of S. aureus and 20 carriers were selected. Decolonization was attempted using nasal mupirocin (10 animals) or mupirocin plus trimethoprim/sulfadiazine intramuscularly (10 animals) both once daily for 5 days, and checked by follow-up cultures for 10 weeks...
2018: PloS One
https://www.readbyqxmd.com/read/29606181/effect-of-intranasal-mupirocin-prophylaxis-on-methicillin-resistant-staphylococcus-aureus-transmission-and-invasive-staphylococcal-infections-in-a-neonatal-intensive-care-unit
#2
Elizabeth H Ristagno, Kristina A Bryant, Lynette F Boland, Gordon G Stout, Alan D Junkins, Charles R Woods, John A Myers, Claudia M Espinosa
The use of monthly intranasal mupirocin was associated with a significant reduction in the rate of methicillin-resistant Staphylococcus aureus transmission and Staphylococcus aureus invasive infection in a large neonatal intensive care unit. Resistance to mupirocin emerged over time, but it was rare and was not associated with adverse clinical outcomes.Infect Control Hosp Epidemiol 2018;1-5.
April 2, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29592954/synergistic-activity-of-cosecreted-natural-products-from-amoebae-associated-bacteria
#3
Johannes Arp, Sebastian Götze, Ruchira Mukherji, Derek J Mattern, María García-Altares, Martin Klapper, Debra A Brock, Axel A Brakhage, Joan E Strassmann, David C Queller, Bettina Bardl, Karsten Willing, Gundela Peschel, Pierre Stallforth
Investigating microbial interactions from an ecological perspective is a particularly fruitful approach to unveil both new chemistry and bioactivity. Microbial predator-prey interactions in particular rely on natural products as signal or defense molecules. In this context, we identified a grazing-resistant Pseudomonas strain, isolated from the bacterivorous amoeba Dictyostelium discoideum. Genome analysis of this bacterium revealed the presence of two biosynthetic gene clusters that were found adjacent to each other on a contiguous stretch of the bacterial genome...
March 28, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29577266/knowledge-attitudes-and-practices-regarding-methicillin-resistant-staphylococcus-aureus-mrsa-infection-control-and-nasal-mrsa-carriage-rate-among-dental-health-care-professionals
#4
Yeon-Jee Yoo, Eun-Jung Kwak, Kyung Muk Jeong, Seung-Ho Baek, Yoo Sang Baek
BACKGROUND: Dental health-care professionals (DHCPs) with nasal colonisation of methicillin-resistant Staphylococcus aureus (MRSA) can serve as a reservoir for MRSA transmission to others and be exposed to self-contamination with MRSA. Evaluating the knowledge, attitudes and actual practice of DHCPs is imperative for appropriate infection control. METHODS: Dentists, dental hygienists and dental technologists from Seoul National University Dental Hospital were recruited to participate in a cross-sectional survey and undergo nasal sampling of MRSA...
March 25, 2018: International Dental Journal
https://www.readbyqxmd.com/read/29563773/development-of-controlled-release-silicone-adhesive-based-mupirocin-patch-demonstrates-antibacterial-activity-on-live-rat-skin-against-staphylococcus-aureus
#5
Sheba R David, Nurafiqah Malek, Abdul Hanif Mahadi, Srikumar Chakravarthi, Rajan Rajabalaya
Background: Peritonitis is the most serious complication of peritoneal dialysis. Staphylococcus aureus infections could lead to peritonitis which causes reversal of peritoneal dialysis treatment back to hemodialysis. The aim of this study was to develop a controlled release silicone adhesive-based mupirocin patch for prophylactic effect and analyze its antibacterial effectiveness against S. aureus . Methods: The matrix patches were prepared by using different polymers, with and without silicone adhesive, dibutyl sebacate and mupirocin...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29559601/-topical-ozone-therapy-an-innovative-solution-to-patients-with-herpes-zoster
#6
Jian Huang, Jinhua Huang, Yaping Xiang, Lihua Gao, Yizhi Pan, Jianyun Lu
To observe the clinical efficacy and safety of topical ozone therapy for patients with herpes zoster by reflectance confocal microscopy (RCM).
 Methods: A total of 60 patients with herpes zoster were divided into a control group and an ozone treatment group (n=30). In the control group, patients took oral valacyclovir tablets or granules (0.3 g per day, three times a day) and they were subjected to local weak laser irradiation treatment plus topical 2% mupirocin ointment twice a day. In the ozone group, the treatment is same as the control group except mupirocin ointment was replaced with topical ozone treatment (hydrotherapy every day plus ozonated oil twice a day)...
February 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29555678/evaluation-of-the-pig-tailed-macaque-macaca-nemestrina-as-a-model-of-human-staphylococcus-aureus-nasal-carriage
#7
Amy L Cole, Yvonne Cosgrove Sweeney, Amanda G Lasseter, Justin M Gray, Ashley C Beavis, Christine F Chong, Safarali V Hajheidari, Alex Beyene, Dorothy L Patton, Alexander M Cole
Staphylococcus aureus ( SA ) nasal carriage is a common condition effecting both healthy and immunocompromised populations, and provides a reservoir for dissemination of potentially infectious strains by casual contact. Factors regulating the onset and duration of nasal SA colonization are mostly unknown, and a human-relevant animal model is needed. Here, we screened 17 pig-tailed macaques ( Macaca nemestrina ) for SA carriage, and 14 of 17 animals tested positive in the nose at one or both screening sessions (8 weeks apart), while the other three animals were negative in the nose but positive in the pharynx at least once...
March 19, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29516425/infections-after-photodynamic-therapy-in-condyloma-acuminatum-patients-incidence-and-management
#8
Xin Yu, Heyi Zheng
Condyloma acuminatum (CA), or genital wart, is a sexually transmitted infection caused by human papillomaviruses. Increasing evidences demonstrated that photodynamic therapy (PDT) is effective in eliminating latent HPV infection, the major reason for CA recurrence. We observed an increasing number of infections after PDT in CA patients, which has not been reported before. This study aims to evaluate the incidence and management of infection in CA patients after PDT procedure. CA patients received PDT from January 2015 to February 2016 at the outpatient setting...
March 7, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29506927/cost-efficacy-of-methicillin-resistant-staphylococcus-aureus-decolonization-with-intranasal-povidone-iodine
#9
G Ryan Rieser, Joseph T Moskal
BACKGROUND: With increasing rates of virulent drug resistant organisms, MRSA (methicillin-resistant Staphylococcus aureus) decolonization has been demonstrated to decrease infection rates. Recent research has shown the antiseptic povidone-iodine to be equally effective and potentially cost saving compared to intranasal mupirocin. This study's purpose is to evaluate the incidence of MRSA colonization in a more rural community-based population, rates of infection on a mupirocin decolonization protocol, and develop a cost analysis model to compare costs of utilizing povidone-iodine...
January 31, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29475889/correction-for-mercer-et-al-np108-an-antimicrobial-polymer-with-activity-against-methicillin-and-mupirocin-resistant-staphylococcus-aureus
#10
Derry K Mercer, Laura K Katvars, Fiona Hewitt, Daniel W Smith, Jennifer Robertson, Carol A Munro, Deborah A O'Neil
No abstract text is available yet for this article.
March 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29473540/-prevention-of-postoperative-infections-patient-safety-subordinated-to-antibiotic-stewardship
#11
M J M Bonten, J Kluytmans
A new Dutch guideline for surgical antimicrobial prophylaxis recommends preoperative treatment with mupirocin and chlorhexidine showers only in patients identified as nasal carriers of Staphylococcus aureus. Yet, preoperative screening and treatment may not be achieved in many patients, because of the infrastructural complexity of all procedures this requires. We are therefore pleading for a universal treatment approach, which is more cost-effective and precludes carriers from being missed, while monitoring the occurrence of S...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29468052/prevalence-of-staphylococcus-spp-nasal-colonization-among-doctors-of-podiatric-medicine-and-associated-risk-factors-in-spain
#12
Sheila de Benito, Luis Alou, Ricardo Becerro-de-Bengoa-Vallejo, Marta Elena Losa-Iglesias, María Luisa Gómez-Lus, Luis Collado, David Sevillano
Background: This study aimed to estimate the prevalence of methicillin-susceptible and -resistant Staphylococcus aureus (MSSA and MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) nasopharyngeal carriage among Doctors of Podiatric Medicine (Podiatrists) and to determine the potential risk factors. Methods: A cross-sectional study was carried out in 2016-2017 among 239 podiatrists in Spain. The presence of MSSA, MRSA, and MRSE was determined by microbiological analysis of nasal exudate and antimicrobial susceptibility was determined...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29463447/novel-inhibitors-of-staphylococcus-aureus-rnpa-that-synergize-with-mupirocin
#13
Nicole Lounsbury, Tess Eidem, Jennifer Colquhoun, George Mateo, Magid Abou-Gharbia, Paul M Dunman, Wayne E Childers
We recently discovered RnpA as a promising new drug discovery target for methicillin-resistant S. aureus (MRSA). RnpA is an essential protein that is thought to perform two required cellular processes. As part of the RNA degrasome Rnpa mediates RNA degradation. In combination with rnpB it forms RNase P haloenzymes which are required for tRNA maturation. A high throughput screen identified RNPA2000 as an inhibitor of both RnpA-associated activities that displayed antibacterial activity against clinically relevant strains of S...
April 1, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29422820/decolonization-of-staphylococcus-aureus-in-patients-with-atopic-dermatitis-a-reason-for-increasing-resistance-to-antibiotics
#14
Izabela Błażewicz, Maciej Jaśkiewicz, Marta Bauer, Lidia Piechowicz, Roman J Nowicki, Wojciech Kamysz, Wioletta Barańska-Rybak
Introduction: Exacerbation of atopic dermatitis can be associated with bacterial infection. The skin of patients is colonized with Staphylococcus aureus in 90% of cases. An attempt has been made to demonstrate that eradication significantly reduces the severity of the disease. Studies indicate the efficacy of topical antibiotics, topical corticosteroids and calcineurin inhibitors. Due to increasing resistance to drugs and the defective antimicrobial peptide profile, decolonization is virtually impossible...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29370836/successful-eradication-of-newly-acquired-mrsa-in-six-of-seven-patients-with-cystic-fibrosis-applying-a-short-term-local-and-systemic-antibiotic-scheme
#15
Alexander Kiefer, Christian Bogdan, Volker O Melichar
BACKGROUND: In individuals with cystic fibrosis (CF), colonization with methicillin-resistant Staphylococcus aureus (MRSA) was reported to be associated with a deterioration of pulmonary disease as reflected by an accelerated decline in lung function. Thus, an early eradication of MRSA could be beneficial in these patients. Here, we report on an intensified MRSA eradication protocol. METHODS: Since 2012 a protocol for the eradication of newly acquired MRSA has been used in our CF Clinic, combining oral rifampicin and fusidic acid, inhaled vancomycin, nasal mupirocin, local antiseptic treatment and hygienic directives all of which are applied for only 7 days during an inpatient hospital stay...
January 25, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29363252/fine-tuning-of-antibiotic-activity-by-a-tailoring-hydroxylase-in-a-trans-at-polyketide-synthase-pathway
#16
Hadi H Mohammad, Jack A Connolly, Zhongshu Song, Joanne Hothersall, Paul R Race, Christine L Willis, Thomas J Simpson, Peter J Winn, Christopher M Thomas
The addition or removal of hydroxy groups modulates the activity of many pharmacologically active biomolecules. It can be integral to the basic biosynthetic factory or result from associated tailoring steps. For the anti-MRSA antibiotic mupirocin, removal of a C8-hydroxy group late in the biosynthetic pathway gives the active pseudomonic acid A. An extra hydroxylation, at C4, occurs in the related but more potent antibiotic thiomarinol A. We report here in vivo and in vitro studies that show that the putative non-haem-iron(II)/α-ketoglutaratedependent dioxygenase TmuB, from the thiomarinol cluster, 4-hydroxylates various pseudomonic acids whereas C8-OH, and other substituents around the tetrahydropyran ring, block enzyme action but not substrate binding...
April 16, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29363211/low-prevalence-of-mupirocin-resistance-in-staphylococcus-pseudintermedius-isolates-from-canine-pyoderma-in-korea
#17
Ji-Hyung Park, Jung-Hun Kang, Jae-Eun Hyun, Cheol-Yong Hwang
BACKGROUND: Mupirocin is a topical antibacterial drug used for the treatment of staphylococcal infections, including meticillin-resistant Staphylococcus pseudintermedius (MRSP). The recent emergence of resistance to mupirocin is a major concern in many countries. OBJECTIVES: This study investigated the prevalence and genotype of mupirocin-resistant S. pseudintermedius isolated from pet dogs with pyoderma. SAMPLES: A total of 110 clinical isolates of S...
April 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29357913/screening-of-methicillin-resistant-staphylococcus-aureus-nasal-colonization-among-elective-surgery-patients-in-referral-hospital-in-indonesia
#18
Erni J Nelwan, Robert Sinto, Decy Subekti, Randy Adiwinata, Lia Waslia, Tonny Loho, Dodi Safari, Djoko Widodo
OBJECTIVE: Methicillin-resistant Staphylococcus aureus (MRSA) colonization is associated with serious surgical site infection in high-risk patients. High prevalence of MRSA colonization was reported in many settings, nonetheless local data is required. The purpose of this study is to identify the prevalence and risk factor of MRSA nasal carriage in adult patients in National Referral Hospital in Indonesia before underwent elective surgical procedure. RESULTS: From 384 patients, 16...
January 22, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29349539/effect-of-the-application-of-a-bundle-of-three-measures-intraperitoneal-lavage-with-antibiotic-solution-fascial-closure-with-triclosan-coated-sutures-and-mupirocin-ointment-application-on-the-skin-staples-on-the-surgical-site-infection-after-elective-laparoscopic
#19
Jaime Ruiz-Tovar, Carolina Llavero, Vicente Morales, Carlos Gamallo
BACKGROUND: Surgical site infection (SSI) prevention bundles include the simultaneous use of different measures, which individually have demonstrated an effect on prevention of SSI. The implementation of bundles can yield superior results to the implementation of individual measures. The aim of this study was to address the effect of the application of a bundle including intraperitoneal lavage with antibiotic solution, fascial closure with Triclosan-coated sutures and Mupirocin ointment application on the skin staples, on the surgical site infection after elective laparoscopic colorectal cancer surgery...
January 18, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29345185/drugging-trna-aminoacylation
#20
Joanne M Ho, Erol Bakkalbasi, Dieter Söll, Corwin A Miller
Inhibition of tRNA aminoacylation has proven to be an effective antimicrobial strategy, impeding an essential step of protein synthesis. Mupirocin, the well-known selective inhibitor of bacterial isoleucyl-tRNA synthetase, is one of three aminoacylation inhibitors now approved for human or animal use. However, design of novel aminoacylation inhibitors is complicated by the steadfast requirement to avoid off-target inhibition of protein synthesis in human cells. Here we review available data regarding known aminoacylation inhibitors as well as key amino-acid residues in aminoacyl-tRNA synthetases (aaRSs) and nucleotides in tRNA that determine the specificity and strength of the aaRS-tRNA interaction...
January 18, 2018: RNA Biology
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