keyword
MENU ▼
Read by QxMD icon Read
search

Mupirocin

keyword
https://www.readbyqxmd.com/read/28630179/antibiotic-resistance-as-a-stress-response-recovery-of-high-level-oxacillin-resistance-in-methicillin-resistant-s-aureus-mrsa-auxiliary-fem-mutants-by-induction-of-the-stringent-stress-response
#1
Choon Keun Kim, Catarina Milheiriço, Hermínia de Lencastre, Alexander Tomasz
Studies with MRSA strain COL have shown that the optimal resistant phenotype requires not only mecA but also a large number of "auxiliary genes" identified by Tn551 mutagenesis. The majority of auxiliary mutants showed greatly increased levels of oxacillin resistance when grown in the presence of sub-MIC concentrations of mupirocin - suggesting that the mechanism of reduced resistance in the auxiliary mutants involved interruption of a stringent stress response causing reduced production of PBP2A.
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28626456/bactericidal-effect-of-photodynamic-therapy-alone-or-in-combination-with-mupirocin-or-linezolid-on-staphylococcus-aureus
#2
Vanesa Pérez-Laguna, Luna Pérez-Artiaga, Verónica Lampaya-Pérez, Isabel García-Luque, Sofía Ballesta, Santi Nonell, Manuel P Paz-Cristobal, Yolanda Gilaberte, Antonio Rezusta
Antibiotic treatments frequently fail due to the development of antibiotic resistance, underscoring the need for new treatment strategies. Antimicrobial photodynamic therapy (aPDT) could constitute an alternative therapy. In bacterial suspensions of Staphylococcus aureus, which is commonly implicated in cutaneous and mucosal infections, we evaluated the in vitro efficacy of aPDT, using the photosensitizing agents rose bengal (RB) or methylene blue (MB), alone or combined with the antibiotics mupirocin (MU) or linezolid (LN)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28607014/np108-an-antimicrobial-polymer-with-activity-against-methicillin-and-mupirocin-resistant-staphylococcus-aureus
#3
Derry K Mercer, Laura K Katvars, Fiona Hewitt, Daniel W Smith, Jennifer Robertson, Deborah A O'Neil
Staphylococcus aureus is a clinically significant human pathogen that causes infectious diseases ranging from skin and soft tissue infections (SSTI), healthcare associated infections (HAI) to potentially fatal bacteraemia and endocarditis. Nasal carriage of S. aureus, especially persistent carriage, is associated with an increased risk of subsequent infection, particularly nosocomial and surgical site infections (SSI), usually via autoinfection. NP108 is a cationic antimicrobial polymer composed of Generally Recognized as Safe (GRAS) amino acid building blocks...
June 12, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28600216/molecular-epidemiology-and-antibiotic-resistance-of-methicillin-resistant-staphylococcus-aureus-circulating-in-the-russian-federation
#4
Vladimir Gostev, Alexander Kruglov, Olga Kalinogorskaya, Olga Dmitrenko, Olga Khokhlova, Tatsuo Yamamoto, Yuri Lobzin, Irina Ryabchenko, Sergey Sidorenko
The aim of this study was to investigate the patterns of antimicrobial resistance and molecular features of methicillin-resistant Staphylococcus aureus (MRSA) isolates in Russia. Isolates recovered from hospital patients (n=480), healthy medical personnel (n=25), and healthy carriers (n=13) were included in the study. Hospital-acquired MRSA (HA-MRSA) demonstrated high resistance to ciprofloxacin, gentamicin, and chloramphenicol (76%-92%), moderate - to tetracycline, erythromycin, clindamycin, and rifampicin (38%-54%), and low - to fusidic acid, co-trimoxazole, mupirocin, and daptomycin (2%-7%)...
June 7, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28592549/emergence-of-a-staphylococcus-aureus-clone-resistant-to-mupirocin-and-fusidic-acid-carrying-exotoxin-genes-and-causing-mainly-skin-infections
#5
Anastassios Doudoulakakis, Iris Spiliopoulou, Nikolaos Spyridis, Nikolaos Giormezis, John Kopsidas, Maria Militsopoulou, Evangelia Lebessi, Maria Tsolia
Objectives: Skin and soft tissue infections (SSTIs) caused by mupirocin-resistant Staphylococcus aureus strains have recently increased in our settings. We sought to evaluate the characteristics of these cases over a 43-month period.Methods: All community-acquired staphylococcal infections caused by mupirocin-resistant strains were retrospectively reviewed. Genes encoding high level (HLR) mupirocin resistance (mupA), fusidic acid resistance (fusB), ermA, ermC, PVL (lukS/lukF-PV), exfoliative toxins (eta, etb), fibronectin binding protein A (fnbA) were investigated in 102 preserved selected strains by PCRs...
June 7, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28592405/current-and-emerging-topical-antibacterials-and-antiseptics-agents-action-and-resistance-patterns
#6
REVIEW
Deborah A Williamson, Glen P Carter, Benjamin P Howden
Bacterial skin infections represent some of the most common infectious diseases globally. Prevention and treatment of skin infections can involve application of a topical antimicrobial, which may be an antibiotic (such as mupirocin or fusidic acid) or an antiseptic (such as chlorhexidine or alcohol). However, there is limited evidence to support the widespread prophylactic or therapeutic use of topical agents. Challenges involved in the use of topical antimicrobials include increasing rates of bacterial resistance, local hypersensitivity reactions (particularly to older agents, such as bacitracin), and concerns about the indiscriminate use of antiseptics potentially coselecting for antibiotic resistance...
July 2017: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/28585795/-decolonization-for-staphylococcus-aureus-carriers-in-arthroplasty-surgery-after-hip-fracture
#7
J M Barbero, J Romanyk, A Vallés, M A Plasencia, E Montero, J López
OBJECTIVE: Staphylococcus aureus is the main causative agent of joint prosthesis infections. The decolonization of the carriers is effective in the prevention of the infections of the elective arthroplasties. The aim of this study is to evaluate if it is also in arthroplasties after hip fracture. METHODS: Study in patients with hip fracture who underwent joint prosthesis from January 2011 to December 2015 with a protocol of S. aureus detection-decolonization with intranasal mupirocin and chlorhexidine baths...
June 5, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28581830/development-of-a-topical-mupirocin-spray-for-antibacterial-and-wound-healing-applications
#8
Rutthapol Sritharadol, Titpawan Nakpheng, Paul Wan Sia Heng, Teerapol Srichana
OBJECTIVE: The aim of this study was to develop mupirocin topical spray using Eudragit E100 as a film-forming agent for the treatment of bacterial skin infections as well as to promote wound healing. MATERIALS AND METHODS: Twenty-seven of mupirocin formulations were formulated containing Eudragit E100 and other excipients. Mupirocin spray was prepared by aerosol crimping and filling machine using HFA-134a as a propellant. The formulations were evaluated for their stability and physicochemical properties...
June 18, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28581672/preliminary-investigations-into-developing-all-d-omiganan-for-treating-mupirocin-resistant-mrsa-skin-infections
#9
Siew Mei Samantha Ng, Shu Wei Teo, Yaqing Elena Yong, Fui Mee Ng, Qiu Ying Lau, Roland Jureen, Jeffrey Hill, C S Brian Chia
Staphylococcus aureus is the primary pathogen responsible for the majority of human skin infections and meticillin-resistant Staphylococcus aureus (MRSA) currently presents a major clinical concern. The overuse of Mupirocin, the first-line topical antibacterial drug over 30 years has led to the emergence of Mupirocin-resistant MRSA, creating a clinical concern. The antimicrobial peptide Omiganan was touted to be a promising antibacterial drug candidate due to its rapid membrane-disrupting bactericidal mode of action, entering clinical trials in 2005 as a topical gel to prevent catheter site infections...
June 5, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28578731/bacterial-infections-in-neonates-following-mupirocin-based-mrsa-decolonization-a-multicenter-cohort-study
#10
Rebecca Pierce, Kristina Bryant, Alexis Elward, Justin Lessler, Aaron M Milstone
OBJECTIVE To characterize the risk of infection after MRSA decolonization with intranasal mupirocin. DESIGN Multicenter, retrospective cohort study. SETTING Tertiary care neonatal intensive care units (NICUs) from 3 urban hospitals in the United States ranging in size from 45 to 100 beds. METHODS MRSA-colonized neonates were identified from NICU admissions occurring from January 2007 to December 2014, during which a targeted decolonization strategy was used for MRSA control. In 2 time-to-event analyses, MRSA-colonized neonates were observed from the date of the first MRSA-positive surveillance screen until (1) the first occurrence of novel gram-positive cocci in sterile culture or discharge or (2) the first occurrence of novel gram-negative bacilli in sterile culture or discharge...
June 5, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28577844/preoperative-staphylococcus-aureus-screening-and-targeted-decolonization-in-cardiac-surgery
#11
Manoj K Saraswat, Jonathan T Magruder, Todd C Crawford, Julia M Gardner, Damon Duquaine, Marc S Sussman, Lisa L Maragakis, Glenn J Whitman
BACKGROUND: We assessed the impact of preoperative Staphylococcus aureus screening and targeted decolonization on the incidence of postoperative methicillin-resistant S aureus (MRSA) colonization, intensive care unit MRSA transmission, and surgical site infections in cardiac surgery patients. METHODS: We reviewed medical records for all adult patients during two periods: preintervention (January 2007 to April 2010) and intervention (January 2011 to December 2014)...
June 1, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28537862/erythrasma-a-report-of-nine-men-successfully-managed-with-mupirocin-2-ointment-monotherapy
#12
Tanya Greywal, Philip R Cohen
BACKGROUND: Erythrasma is a benign dermatosis that typically occurs on intertriginous skin. PURPOSE: We describe a series of nine men with erythrasma that were successfully treated with mupirocin 2% ointment monotherapy. METHODS AND MATERIALS: We reviewed PubMed for the following terms: erythrasma, mupirocin, ointment, treatment. We also reviewed papers containing these terms and their references. RESULTS: Complete resolution of erythrasma occurred following monotherapy with twice daily application of mupirocin 2% ointment...
May 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28533232/potentiation-of-antibiotic-activity-by-a-novel-cationic-peptide-potency-and-spectrum-of-activity-of-spr741
#13
David Corbett, Andrew Wise, Tara Langley, Kirsty Skinner, Emily Trimby, Stephen Birchall, Alain Dorali, Stephanie Sandiford, Jennifer Williams, Peter Warn, Martti Vaara, Troy Lister
Novel approaches to the treatment of multi-drug resistant Gram-negative bacterial infections are urgently required. One approach is to potentiate the efficacy of existing antibiotics whose spectrum of activity is limited by the permeability barrier presented by the Gram-negative outer membrane. Cationic peptides derived from polymyxin B have been used to permeabilize the outer membrane, granting antibiotics that would otherwise be excluded access to their targets. We assessed the in vitro efficacy of combinations of SPR741 with conventional antibiotics against Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii Of 35 antibiotics tested, the MICs of eight were reduced 32- to 8,000-fold against E...
May 22, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28529090/continued-expansion-of-usa300-like-methicillin-resistant-staphylococcus-aureus-mrsa-among-hospitalized-patients-in-the-united-states
#14
Isabella A Tickler, Richard V Goering, Jose R Mediavilla, Barry N Kreiswirth, Fred C Tenover
We characterized spa types, SCCmec types, and antimicrobial resistance patterns of 516 methicillin-resistant Staphylococcus aureus (MRSA) isolates, collected between 2011 and 2014 from nares and blood cultures of United States patients. Among nares isolates, 45 spa types were observed; 29.9% were t002/SCCmec II and 30.9% were t008/SCCmec IV. Among blood isolates, 40 spa types were identified; 24.4% were t002/SCCmec II and 39.9% were type t008/SCCmec IV. Compared to data from our 2009-2010 survey, the percentage of t008/SCCmec IV isolates from nares increased significantly (20...
May 6, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28516472/nasal-decontamination-for-the-prevention-of-surgical-site-infection-in-staphylococcus-aureus-carriers
#15
REVIEW
Zhenmi Liu, Gill Norman, Zipporah Iheozor-Ejiofor, Jason Kf Wong, Emma J Crosbie, Peter Wilson
BACKGROUND: Surgical site infection rates in the month following surgery vary from 1% to 5%. Due to the large number of surgical procedures conducted annually, the costs of these surgical site infections (SSIs) can be considerable in financial and social terms. Nasal decontamination using antibiotics or antiseptics is performed to reduce the risk of SSIs by preventing organisms from the nasal cavity being transferred to the skin where a surgical incision will be made. Staphylococcus aureus (S aureus) colonises the nasal cavity and skin of carriers and can cause infection in open or unhealed surgical wounds...
May 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28489239/therapeutic-effect-of-hyaluronic-acid-in-reducing-nasal-mucosa-recovery-time-after-septoplasty
#16
Francesco Klinger, Fabio Caviggioli, Andrea Vittorio Lisa, Luca Maione, Valeriano Vinci, Mattia Siliprandi, Federico Barbera, Marco Klinger, Luca Malvezzi
Mucociliary clearance represents a host defense mechanism of airways that can be compromised by various pathologic conditions, such as nasal septal deviation. Although septoplasty can resolve obstruction, it impairs mucociliary clearance in the immediate postoperative period. Clinical studies have demonstrated how hyaluronic acid can interfere with this function. Our study aims to provide evidence of a therapeutic effect of hyaluronic acid on nasal mucosa recovery after septoplasy. Sixty-five patients underwent septoplasty...
April 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28482540/dual-layered-3d-nanofibrous-matrix-incorporated-with-dual-drugs-and-their-synergetic-effect-on-accelerating-wound-healing-through-growth-factor-regulation
#17
Sivakumar Singaravelu, Giriprasath Ramanathan, Uma Tiruchirapalli Sivagnanam
The by-product of the slaughter house was utilized for the development of promising regenerative wound dressing material. Currently, dual-layered nanofibrous spongy scaffold was fabricated for tissue engineering applications. Herein, Keratin (K)-Fibrin (F)-Gelatin (G) 3D sponge loaded with Mupirocin (M) was fabricated with the naturally derived materials from bovine origin using freeze drying method. Moreover, poly(3-hydroxybutyric acid) (P) and Gelatin(G) solution loaded with Curcumin (C) were electrospun to get the dual drug loaded dual-layered nanofibrous spongy 3D scaffold (KFG:M-PG:C)...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28462776/a-simple-way-to-eradicate-methicillin-resistant-staphylococcus-aureus-in-cynomolgus-macaques-macaca-fascicularis
#18
Tae M Kim, Hyojun Park, Kyo W Lee, Eun W Choi, Sang H Moon, Yong S Lee, Kahee Cho, Wan J Park, Jae B Park, Sung J Kim
Our investigation of indoor-housed cynomolgus macaques (Macaca fascicularis) by using automated identification followedbyantibiotic susceptibility testing revealed 1 of 7 immunocompetent animals and 2 of 9 immunosuppressed monkeys as carriers ofmethicillin-resistant Staphylococcus aureus (MRSA). Follow-up management involving mupirocin treatment resulted in the conversion of the 3 MRSA carriers into MRSA-negative cases. Prospective assessment of newly imported monkeys involving 24-h culture of nasal swabs on chromogenic agar revealed that 22% (18 of 82 animals) were MRSA-positive...
May 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28430424/elucidation-of-the-stereospecificity-of-c-methyltransferases-from-trans-at-polyketide-synthases
#19
Xinqiang Xie, Chaitan Khosla, David E Cane
S-Adenosyl methionine (SAM)-dependent C-methyltransferases are responsible for the C2-methylation of 3-ketoacyl-acyl carrier protein (ACP) intermediates to give the corresponding 2-methy-3-ketoacyl-ACP products during bacterial polyketide biosynthesis mediated by trans-AT polyketide synthases that lack integrated acyl transferase (AT) domains. A coupled ketoreductase (KR) assay was used to assign the stereochemistry of the C-methyltransferase-catalyzed reaction. Samples of chemoenzymatically generated 3-ketopentanoyl-ACP (9) were incubated with SAM and BonMT2 from module 2 of the bongkrekic acid polyketide synthase...
May 3, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28425049/erratum-to-successful-management-of-zoon-s-balanitis-with-topical-mupirocin-ointment-a-case-report-and-literature-review-of-mupirocin-responsive-balanitis-circumscripta-plasmacellularis
#20
keyword
keyword
39654
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"