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extended spectrum beta lactamase

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https://www.readbyqxmd.com/read/28096977/high-rates-of-multidrug-resistance-among-uropathogenic-escherichia-coli-in-children-and-analyses-of-esbl-producers-from-nepal
#1
Narayan Prasad Parajuli, Pooja Maharjan, Hridaya Parajuli, Govardhan Joshi, Deliya Paudel, Sujan Sayami, Puspa Raj Khanal
BACKGROUND: Emergence of Extended-spectrum beta-lactamase producing Escherichia coli causing urinary tract infections (UTI) among pediatric patients is an increasing problem worldwide. However, very little is known about pediatric urinary tract infections and antimicrobial resistance trend from Nepal. This study was conducted to assess the current antibiotic resistance rate and ESBL production among uropathogenic Escherichia coli in pediatric patients of a tertiary care teaching hospital of Nepal...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28076388/risk-factors-for-multi-drug-resistant-pathogens-and-failure-of-empiric-first-line-therapy-in-acute-cholangitis
#2
Philipp A Reuken, Dorian Torres, Michael Baier, Bettina Löffler, Christoph Lübbert, Norman Lippmann, Andreas Stallmach, Tony Bruns
BACKGROUND: Acute cholangitis (AC) requires the immediate initiation of antibiotic therapy in addition to treatment for biliary obstruction. Against a background of an increasing prevalence of multi-drug resistant (MDR) bacteria, the risk factors for the failure of empiric therapy must be defined. METHODS: Using a pathogen-based approach, 1764 isolates from positive bile duct cultures were retrospectively analyzed to characterize the respective pathogen spectra in two German tertiary centers...
2017: PloS One
https://www.readbyqxmd.com/read/28074126/the-emergence-of-carbapenem-resistant-klebsiella-pneumoniae-in-malaysia-correlation-between-microbiological-trends-with-host-characteristics-and-clinical-factors
#3
Ye-Mun Low, Polly Soo-Xi Yap, Kartini Abdul Jabar, Sasheela Ponnampalavanar, Rina Karunakaran, Rukumani Velayuthan, Chun-Wie Chong, Sazaly Abu Bakar, Mohd Yasim Md Yusof, Cindy Shuan-Ju Teh
BACKGROUND: Carbapenem resistant Enterobacteriaceae is a growing concern worldwide including Malaysia. The emergence of this pathogen is worrying because carbapenem is one of the 'last-line' antibiotics. The main objective of this study was to determine the prevalence of genetic mechanisms and clinical risk factors of carbapenem resistant Klebsiella pneumoniae (K. pneumoniae) in Malaysia. METHODS: In this study, seventeen carbapenem resistant K. pneumoniae strains isolated from a tertiary teaching hospital in 2013 were studied...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28062884/extended-spectrum-beta-lactamase-producing-enterobacteriaceae-in-retail-chicken-meat-in-singapore
#4
Eugene Jz Lim, Si Xian Ho, Delphine Yh Cao, Quek Choon Lau, Tse Hsien Koh, Li Yang Hsu
No abstract text is available yet for this article.
December 2016: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/28061803/evaluation-of-mlva-for-epidemiological-typing-and-outbreak-detection-of-esbl-producing-escherichia-coli-in-sweden
#5
Lisa Helldal, Nahid Karami, Christina Welinder-Olsson, Edward R B Moore, Christina Åhren
BACKGROUND: To identify the spread of nosocomial infections and halt outbreak development caused by Escherichia coli that carry multiple antibiotic resistance factors, such as extended-spectrum beta-lactamases (ESBLs) and carbapenemases, is becoming demanding challenges due to the rapid global increase and constant and increasing influx of these bacteria from the community to the hospital setting. Our aim was to assess a reliable and rapid typing protocol for ESBL-E. coli, with the primary focus to screen for possible clonal relatedness between isolates...
January 6, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28054236/antibiotic-resistance-patterns-of-escherichia-coli-urinary-isolates-and-comparison-with-antibiotic-consumption-data-over-10%C3%A2-years-2005-2014
#6
P J Stapleton, D J Lundon, R McWade, N Scanlon, M M Hannan, F O'Kelly, M Lynch
INTRODUCTION: Escherichia coli is a common cause of urinary tract infections (UTI). Reviews of antibiotic resistance of this organism can inform choice of empiric treatment of UTI and other infections and strategies for combating antimicrobial resistance. We reviewed laboratory and hospital pharmacy records to assess trends in non-susceptibility rates and the effect of antimicrobial stewardship interventions. METHODS: A retrospective observational study of isolates of E...
January 4, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28036312/antimicrobial-resistance-of-selected-invasive-bacteria-in-a-tertiary-care-center-results-of-a-prospective-surveillance-study
#7
Olivera Djuric, Snezana Jovanovic, Branka Stosovic, Tanja Tosic, Milica Jovanovic, Ljiljana Markovic-Denic
INTRODUCTION: We aimed to report the distribution and resistance patterns of eight invasive clinically relevant bacteria surveyed in the Clinical Center of Serbia (CCS) in Belgrade. METHODOLOGY: A total of 477 clinical blood stream isolates of Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecium, Enterococcus faecalis, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter spp. were collected in the period from January to December 2013...
December 30, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28036049/antimicrobial-resistant-enteropathogenic-escherichia-coli-and-salmonella-spp-in-houseflies-infesting-fish-in-food-markets-in-zambia
#8
Mwansa M Songe, Bernard M Hang'ombe, Theodore J D Knight-Jones, Delia Grace
Diarrhea is one of the most common diseases and is a leading cause of death in developing countries. This is often caused by contaminated food. Poor food hygiene standards are exacerbated by the presence of flies which can transmit a variety of infectious microorganisms, particularly through animal source foods. This fact becomes especially important in developing countries like Zambia, where fish is a highly valued source of protein. Our interest in this study was to identify if the flies that beset food markets in Zambia carry important pathogenic bacteria on their bodies, and subsequently if these bacteria carry resistance genes to commonly used antibiotics, which would indicate problems in eradicating these pathogens...
December 28, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28018690/multiple-renal-abscesses-due-to-esbl-extended-spectrum-beta-lactamase-producing-escherichia-coli-causing-acute-pyelonephritis-and-bacteremia-a-case-report-with-a-good-outcome-no-drainage-required
#9
Abdalla Khalil, Musaad Qurash, Asem Saleh, Rasha Ali, Mohamed Elwakil
Extended-spectrum beta-lactamase-producing Enterobacteriaceae urinary tract infections are challenging infections with increased mortality, morbidity, and failure of therapy. A 44-year-old Saudi male diabetic patient was seen at the ER of IMC Hospital with features of acute pyelonephritis: fever, burning urine, and left flank pain for three days. He was treated for cystitis at the Endocrine Clinic two weeks prior to his ER visit with nitrofurantoin and levofloxacin orally according to urine culture and sensitivity result...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28018582/carriage-of-esbl-ampc-producing-or-ciprofloxacin-non-susceptible-escherichia-coli-and-klebsiella-spp-in-healthy-people-in-norway
#10
Charlotte R Ulstad, Margrete Solheim, Sophie Berg, Morten Lindbæk, Ulf R Dahle, Astrid L Wester
BACKGROUND: Asymptomatic carriage has been recognised as an important risk factor for infection caused by antibiotic resistant bacteria. A 14% global prevalence of Extended-Spectrum Beta-lactamase (ESBL) carriage was recently reported, but large intra-and interregional variations were observed. We investigated the faecal carriage rates of ESBL-, AmpC-producing and ciprofloxacin non-susceptible Escherichia coli and Klebsiella spp. in healthy Norwegians. METHODS: Rectal samples were obtained from 284 volunteers, together with demographic data and information on recent travel history...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28011968/extended-spectrum-beta-lactamase-producing-enterobacteriaceae-among-the-pediatric-population-who-is-at-risk-and-why-results-from-a-single-centre-prospective-study
#11
Carmelina Calitri, Carlo Scolfaro, Sara Colombo, Gianfranco De Intinis, Francesca Carraro, Silvia Garazzino, Pier-Angelo Tovo
A prospective 18-month case-control study was performed in a tertiary Paediatric Centre in Turin (Italy) to analyse the disease burden and identify risk factors for acquisition of Extended Spectrum Beta Lactamase-producing Enterobacteriaceae (ESBL-pE). Children with ESBL-pE isolation were enrolled as cases, with controls matched according to age, type of pathogen isolated and sample of isolation. Out of 83 children (37 males, mean age 4.7 ± 5.46 years), 45 were identified as infected (54.2%) and 38 as colonised (45...
1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28003592/antibiotic-susceptibilities-and-genetic-characterization-of-extended-spectrum-beta-lactamase-producing-escherichia-coli-isolated-from-stools-of-pediatric-diarrhea-patients-in-surabaya-indonesia
#12
Eddy Bagus Wasito, Katsumi Shigemura, Kayo Osawa, Alpha Fardah, Akiho Kanaida, Dadik Raharjo, K Kuntaman, Usman Hadi, Sugeng Harijono, Subijanto Marto Sudarmo, Tatsuya Nakamura, Keigo Shibayama, Masato Fujisawa, Toshiro Shirakawa
The purpose of this study was to investigate extended-spectrum beta-lactamase (ESBL)-producing E. coli isolated from pediatric (0-3 year old) diarrhea patients, as well as bacterial antibiotic susceptibilities, ESBL typing, multilocus sequence typing (MLST) typing and diarrheagenic E. coli (DEC)-typing in Surabaya, Indonesia, where this kind of survey is rarely done. ESBL-producing E. coli were detected in 18.8 % of strains. Many ESBL-producing E. coli had significantly less susceptibility to gentamicin (p<0...
December 22, 2016: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28000030/colonization-pressure-as-a-risk-factor-of-icu-acquired-multidrug-resistant-bacteria-a-prospective-observational-study
#13
J Masse, A Elkalioubie, C Blazejewski, G Ledoux, F Wallet, J Poissy, S Preau, S Nseir
The primary objective of this study was to evaluate the impact of colonization pressure on intensive care unit (ICU)-acquired multidrug resistant bacteria (MDRB). All patients hospitalized for more than 48 h in the ICU were included in this prospective observational study. MDRB were defined as methicillin resistant Staphylococcus aureus, Pseudomonas aeruginosa resistant to ceftazidime or imipenem, Gram-negative bacilli producing extended-spectrum beta-lactamases (ESBL), and all strains of Acinetobacter baumannii and Stenotrophomonas maltophilia...
December 20, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27992527/first-report-of-group-ctx-m-9-extended-spectrum-beta-lactamases-in-escherichia-coli-isolates-from-pediatric-patients-in-mexico
#14
Jocelin Merida-Vieyra, Agustin De Colsa, Yair Calderon Castañeda, Patricia Arzate Barbosa, Alejandra Aquino Andrade
The aim of this study was to identify the presence of group CTX-M-9 extended spectrum beta-lactamases (ESBL) in clinical Escherichia coli isolates from pediatric patients. A total of 404 non-repeated positive ESBL E. coli isolates were collected from documented clinical infections in pediatric patients over a 2-year period. The identification and susceptibility profiles were determined using an automated system. Isolates that suggested ESBL production based on their resistance profiles to third and fourth generation cephalosporin and monobactam were selected...
2016: PloS One
https://www.readbyqxmd.com/read/27990135/predominance-of-ctx-m-15-among-esbl-producers-from-environment-and-fish-gut-from-the-shores-of-lake-victoria-in-mwanza-tanzania
#15
Nyambura Moremi, Elizabeth V Manda, Linda Falgenhauer, Hiren Ghosh, Can Imirzalioglu, Mecky Matee, Trinad Chakraborty, Stephen E Mshana
Extended-Spectrum Beta-Lactamase (ESBL)-producing bacteria are a common cause of healthcare and community-associated infections worldwide. The distribution of such isolates in the environment and their presence in fish as a result of sewage contamination is not well-studied. Here we examined fish and environmental samples from Mwanza city for the presence of ESBL-producing bacteria. From 196 fish sampled from local markets, 26 (13.3%) contained lactose-fermenting ESBL-producing bacteria, while 39/73 (53.4%) environmental samples from the same area were ESBL producers...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27986632/structural-insight-into-mode-of-binding-of-meropenem-to-ctx-m-15-type-%C3%AE-lactamase
#16
Lubna Maryam, Asad U Khan
Among Enterobacteriaceae, CTX-M type extended spectrum beta lactamase confers potent hydrolytic activity against cephalosporin group of antibiotics. Strains producing CTX-M type beta lactamase enzymes, show high level of resistance against cefotaxime. Therefore carbapenem antibiotics are used against beta lactamase producing strains. Hence, this study was designed to understand an insight of molecular basis of CTX-M-15 interaction with meropenem, and its effect on CTX-M-15 efficiency. Clinical strain of Enterobacter cloacae (EC-15) was used to clone blaCTX-M-15 gene in E...
December 14, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27979787/worrisome-high-frequency-of-extended-spectrum-beta-lactamase-producing-escherichia-coli-in-community-acquired-urinary-tract-infections-a-case-control-study
#17
Franco Castillo-Tokumori, Claudia Irey-Salgado, Germán Málaga
OBJECTIVES: There has been a sustained and dramatic increase in community-acquired urinary tract infections (CA-UTI) caused by extended-spectrum beta-lactamase (ESBL)-producing bacteria over recent years. Despite this, no studies have been performed in low- or middle-income countries. The main objective of this case-control study was to describe ESBL CA-UTI and its risk factors. METHODS: Outpatients with CA-UTI seen at the Hospital Cayetano Heredia during 2015 were identified...
December 12, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27965975/comparison-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-isolates-from-drinking-well-water-and-pit-latrine-wastewater-in-a-rural-area-of-china
#18
Hongna Zhang, Yanxia Gao, Weishan Chang
The present study was conducted to gain insights into the occurrence and characteristics of extended-spectrum beta-lactamase- (ESBL-) producing Escherichia coli (E. coli) from drinking well water in the rural area of Laiwu, China, and to explore the role of the nearby pit latrine as a contamination source. ESBL-producing E. coli from wells were compared with isolates from pit latrines in the vicinity. The results showed that ESBL-producing E. coli isolates, with the same antibiotic resistance profiles, ESBL genes, phylogenetic group, plasmid replicon types, and enterobacterial repetitive intergenic consensus-polymerase chain reaction (ERIC-PCR) fingerprints, were isolated from well water and the nearby pit latrine in the same courtyard...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27957505/bacterial-colonization-and-antibiotic-resistance-in-a-prospective-cohort-of-newborn-infants-during-the-first-year-of-life
#19
Sharon B Meropol, Kurt C Stange, Michael R Jacobs, Judith K Weiss, Saralee Bajaksouzian, Robert A Bonomo
BACKGROUND: Infants are virtually sterile at birth and frequently use antibiotics; our objective was to (1) characterize the longitudinal colonization with bacterial pathogens and associated antibiotic resistance in a cohort of community-dwelling infants in Northeast Ohio and (2) describe longitudinal concurrent antibiotic and daycare exposures. METHODS: For 35 newborns, nasopharyngeal swabs were cultured for Streptococcus pneumoniae, anterior nasal for Staphylococcus aureus, and perirectal for extended-spectrum beta-lactamase (ESBL)-producing Gram-negative enteric bacteria, at 3-month intervals for 12 months...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27956778/study-of-antimicrobial-resistance-due-to-extended-spectrum-beta-lactamase-producing-escherichia-coli-in-healthy-broilers-of-jabalpur
#20
Arpita Shrivastav, R K Sharma, Y P Sahni, Neeraj Shrivastav, Vidhi Gautam, Sachin Jain
AIM: To study the prevalence of antimicrobial resistance due to extended spectrum beta-lactamase (ESBL)-producing Escherichia coli in samples collected from the ceca of healthy broilers of poultry sale outlets (PSOs) Jabalpur. MATERIALS AND METHODS: A total of 400 cecal swab samples were taken randomly from freshly slaughtered poultry of 39 PSOs located at four different zones or areas of Jabalpur and were screened for the presence of ESBL-producing E. coli using standard methods...
November 2016: Veterinary World
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