Read by QxMD icon Read

extended spectrum beta lactamase

Guojun Zhang, Guanghui Zheng, Yan Zhang, Ruimin Ma, Xixiong Kang
Post-neurosurgical meningitis (PNM) is one of the most severe hospital-acquired infections (HAI) worldwide, and a large number of pathogens, especially those possessing multi-resistance genes, are related to these infections. Existing methods for detecting bacteria and measuring their response to antibiotics lack sensitivity and stability, and laboratory-based detection methods are inconvenient, which require at least 24h to complete. Rapid identification of bacteria and the determination of their susceptibility to antibiotics are urgently needed, in order to combat the emergence of multi-resistant bacterial strains...
March 17, 2018: International Journal of Infectious Diseases: IJID
L Armand-Lefèvre, A Andremont, E Ruppé
Bacterial resistance to antibiotics is considered a major threat to health. Enterobacteriaceae have increasingly become resistant to antibiotics through the acquisition and dissemination of extended-spectrum beta-lactamases (ESBL) that confer resistance to most beta-lactams. While ESBL-producing Enterobacteriaceae were formerly restricted to hospitals, they have now spread to community settings, especially in developing countries. The tremendous expansion of international travels contributed to the importation of multidrug-resistant Enterobacteriaceae (MRE) to low prevalence countries...
March 14, 2018: Médecine et Maladies Infectieuses
Sarah Jolivet, Laetitia Vaillant, Thibaut Poncin, Isabelle Lolom, Yannick Gaudonnet, Emilie Rondinaud, Gisèle Bendjelloul, Alexandra Lomont, Jean-Christophe Lucet, Laurence Armand-Lefevre
OBJECTIVES: Our aim was to evaluate the prevalence and associated factors for carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) in a healthcare facility. METHODS: We conducted a serial cross-sectional survey of ESBL-PE carriage in 2016 in a French university hospital. All patients present on the day of the survey were screened for ESBL-PE carriage. Demographic characteristics and risk factors for ESBL-PE carriage were collected...
March 13, 2018: Clinical Microbiology and Infection
Ina Willemsen, Jan Kluytmans
Background: Infection control needs user-friendly standardized instruments to measure the compliance to guidelines and to implement targeted improvement actions. This abstract describes a tool to measure the quality of infection control and antimicrobial use, the Infection Risk Scan (IRIS). It has been applied in a hospital, several nursing homes and a rehabilitation clinic in the Netherlands. Method: The IRIS consists of a set of objective reproducible measurements, combining patient- and healthcare related variables, such as: hand hygiene compliance, environmental contamination using ATP measurements, prevalence of resistant microorganisms by active screening, availability of infection control preconditions, personal hygiene of healthcare workers, appropriate use of indwelling medical devices and appropriate use of antimicrobials...
2018: Antimicrobial Resistance and Infection Control
Congming Wu, Yingchao Wang, Xiaomin Shi, Shuang Wang, Hongwei Ren, Zhangqi Shen, Yang Wang, Juchun Lin, Shaolin Wang
Extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) strains are emerging around the world as a source of resistance to β-lactam antibiotics such as ampicillin, cefotaxime, and ceftazidime. mcr-1 is a novel plasmid-mediated gene conferring resistance to colistin. The aim of this study was to investigate the prevalence of ESBL-EC mcr-1 of chicken origin in the different provinces of China during 2008-2014. Overall, 341 of 821 isolates were determined to be ESBL-EC strains, and the proportion of ESBL-positive strains almost doubled from 2008 to 2014...
March 14, 2018: Emerging Microbes & Infections
Juha Knaapila, Heini Kallio, Antti J Hakanen, Kari Syvänen, Otto Ettala, Esa Kähkönen, Tarja Lamminen, Marjo Seppänen, Ivan Jambor, Antti Rannikko, Jarno Riikonen, Eveliina Munukka, Erkki Eerola, Marianne Gunell, Peter J Boström
OBJECTIVES: To determine, in a prospective, multicenter setting, the prevalence of fluoroquinolone (FQ) resistant and extended spectrum beta lactamase (ESBL) producing E. coli strains in men undergoing transrectal ultrasound guided prostate biopsy (TRUS-Bx) in Finland and to survey the associated risk factors for having the previously mentioned strains. MATERIALS AND METHODS: This is a substudy of the trial investigating the role of magnetic resonance imaging (MRI) in prostate cancer diagnosis (multi-IMPROD, NCT02241122)...
March 13, 2018: BJU International
Susanne Sütterlin, Carlos J Téllez-Castillo, Leticia Anselem, Hong Yin, James E Bray, Martin C J Maiden
Antimicrobial resistance is a major health care problem, with the intensive use of heavy metals and biocides recently being identified as potential contributing factors to the aggravation of this situation. This study investigated heavy metal susceptibility and genetic resistance determinants in Escherichia coli isolated from clinical urine samples from Sweden, Germany and Spain. A total of 186 isolates were tested for minimal inhibition concentration to sodium arsenite, silver nitrate and copper (II) sulphate...
March 12, 2018: Antimicrobial Agents and Chemotherapy
Anna Lena Zogg, Katrin Zurfluh, Sarah Schmitt, Magdalena Nüesch-Inderbinen, Roger Stephan
Among 64 uropathogenic Escherichia coli (UPEC) isolated from 13 cats and 51 dogs, 35 were extended-spectrum beta-lactamase (ESBL) producers, and 29 were non-ESBL producers. Forty-six (71.9%) of the isolates were multidrug resistant (MDR). Among the ESBL producers, blaCTX-M-15 (n = 17/48.6% of the blaESBLs ), blaCTX-M-1 (n = 10/28.6%), blaCTX-M-55 (n = 4/11.4%), blaCTX-M-14 (n = 3/8.6%), and blaCTX-M-27 (n = 1/2.9%) were identified. The plasmid-mediated fluoroquinolone resistance genes aac(6')-Ib-cr, qnrB and the azithromycin resistance gene mph(A) were detected in 17 (26...
March 2018: Veterinary Microbiology
Vera Spatenkova, Ondrej Bradac, Daniela Fackova, Zdenka Bohunova, Petr Suchomel
BACKGROUND: Nosocomial infection (NI) control is an important issue in neurocritical care due to secondary brain damage and the increased morbidity and mortality of primary acute neurocritical care patients. The primary aim of this study was to determine incidence of nosocomial infections and multidrug-resistant bacteria and seek predictors of nosocomial infections in a preventive multimodal nosocomial infection protocol in the neurointensive care unit (NICU). The secondary aim focused on their impact on stay, mortality and cost in the NICU...
March 7, 2018: BMC Neurology
Zahra Hashemizadeh, Davood Kalantar-Neyestanaki, Shahla Mansouri
INTRODUCTION: Multidrug-resistant (MDR) Escherichia coli, a species that is a leading cause of urinary tract infections (UTIs) and is a major global public health concern. This study was designed to detect the differences in antibiotic resistance patterns, the production and type of extended spectrum β-lactamases (ESBLs), and the clonal relationships among E. coli isolates from UTIs and fecal samples. METHODS: Antibacterial resistance was determined by the disk diffusion method...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
María Araque, Indira Labrador
Objectives: Antimicrobial resistant extended-spectrum-β-lactamase-producing Enterobacteriaceae (ESBL-PE) have been shown to be present in healthy communities. This study examined healthy children from the rural Andean village of Llano del Hato, Mérida, Venezuela, who have had little or no antibiotic exposure to determine the prevalence of fecal carriage of ESBL-producing Escherichia coli (ESBL-EC). Methods: A total of 78 fecal samples were collected in healthy children aged from 1 to 5 years...
January 2018: Osong Public Health and Research Perspectives
Kai-Chih Chang, Chin-Yi Chung, Chen-Hsing Yeh, Kuo-Hsiu Hsu, Ya-Ching Chin, Sin-Siang Huang, Bo-Rong Liu, Hsi-An Chen, Anren Hu, Po-Chi Soo, Wen-Ping Peng
The appearance and spread of carbapenem-resistant Acinetobacter baumannii (CRAB) pose a challenge for optimization of antibiotic therapies and outbreak preventions. The carbapenemase production can be detected through culture-based methods (e.g. Modified Hodge Test-MHT) and DNA based methods (e.g. Polymerase Chain Reaction-PCR). The culture-based methods are time-consuming, whereas those of PCR assays need only a few hours but due to its specificity, can only detect known genetic targets encoding carbapenem-resistance genes...
February 27, 2018: Journal of Microbiological Methods
Perlinot Herindrainy, Mamitiana Alain Noah Rabenandrasana, Zafitsara Zo Andrianirina, Feno Manitra Jacob Rakotoarimanana, Michael Padget, Agathe de Lauzanne, Awa Ndir, Elsa Kermorvant-Duchemin, Benoit Garin, Patrice Piola, Jean-Marc Collard, Didier Guillemot, Bich-Tram Huynh, Elisabeth Delarocque-Astagneau
In low and middle income countries (LMICs), where the burden of neonatal sepsis is the highest, the spread of extended spectrum beta-lactamase-producing enterobacteriaceae (ESBL-PE) in the community, potentially contributing to the neonatal mortality, is a public health concern. Data regarding the acquisition of ESBL-PE during the neonatal period are scarce. The routes of transmission are not well defined and particularly the possible key role played by pregnant women. This study aimed to understand the neonatal acquisition of ESBL-PE in the community in Madagascar...
2018: PloS One
Daniele Roberto Giacobbe, Matteo Bassetti, Francesco Giuseppe De Rosa, Valerio Del Bono, Paolo Antonio Grossi, Francesco Menichetti, Federico Pea, Gian Maria Rossolini, Mario Tumbarello, Pierluigi Viale, Claudio Viscoli
Ceftolozane/tazobactam (C/T) is a new antibiotic resulting from the combination of a novel cephalosporin, structurally similar to ceftazidime, with tazobactam, a well-known beta-lactamase inhibitor. C/T remains active against extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae and multi-drug resistant (MDR) P. aeruginosa, and has been recently approved for the treatment of complicated intra-abdominal infections (cIAI) and complicated urinary tract infections (cUTI). A trial on hospital-acquired pneumonia is ongoing...
March 9, 2018: Expert Review of Anti-infective Therapy
Yasuhiro Ikeda, Katsumi Shigemura, Masashi Nomi, Chie Tabata, Koichi Kitagawa, Soichi Arakawa, Masato Fujisawa
We present our experience controlling outbreaks of extended-spectrum beta-lactamase (ESBL)-producing bacteria in catheter-associated urinary tract infection and our measures for preventing recurrence of outbreaks. In June 2015, 9 out of 44 hospitalized patients in the same ward had positive urine culture with antibiotic-resistant bacteria, including ESBL-producing Klebsiella pneumoniae belonging to the same cluster, indicating a localized outbreak. The environmental tests detected resistant strains at 1,000 colony forming units/cm2 or more in 8 out of 10 tests...
February 28, 2018: Japanese Journal of Infectious Diseases
Aurélie Marquet, Marie-Anne Vibet, Jocelyne Caillon, François Javaudin, Guillaume Chapelet, Emmanuel Montassier, Eric Batard
AIMS: Amoxicillin-clavulanate is extensively used in European hospitals. Whether the hospital use of amoxicillin-clavulanate is associated with nonsusceptibility to third-generation cephalosporins (3GC) in Klebsiella pneumoniae is unknown. Our aim was to assess the relationship between the hospital use of amoxicillin-clavulanate and 3GC nonsusceptibility in K. pneumoniae and Escherichia coli. METHODS: Yearly data of antibiotic use and 3GC nonsusceptibility in K...
February 28, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
Flavio G Lipari, Abel H Zárate, Juan J García, Ana L Basquíera, Juan P Caeiro
BACKGROUND: Bloodstream infection is a common complication, which can be life-threatening for hematopoietic stem cells transplant recipients. OBJECTIVE: To analyze the characteristics of bloodstream infections in hematopoietic stem cell transplant recipients. MATERIALS AND METHODS: Observational, retrospective study. We reviewed the records of 451 patients (autologous and allogeneic transplants) from January 2009 to October 2015. RESULTS: 99 positive blood cultures in 73 patients with bloodstream infection (16%) were found...
December 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Francis Onwugamba, J Ross Fitzgerald, Kateryn Rochon, Luca Guardabassi, Abraham Alabi, Stefan Kühne, Martin P Grobusch, Frieder Schaumburg
BACKGROUND: 'Filth flies' feed and develop in excrement and decaying matter and can transmit enteric pathogens to humans and animals, leading to colonization and infection. Considering these characteristics, 'filth flies' are potential vectors for the spread of antimicrobial resistance (AMR). This review defines the role of flies in the spread of AMR and identifies knowledge gaps. METHODS: The literature search (original articles, reviews indexed for PubMed) was restricted to the English language...
February 23, 2018: Travel Medicine and Infectious Disease
Tolbert Sonda, Happiness Kumburu, Marco van Zwetselaar, Michael Alifrangis, Blandina T Mmbaga, Ole Lund, Frank M Aarestrup, Gibson Kibiki
Emergence and spread of extended spectrum beta-lactamase (ESBL)-producing gram-negative bacteria, mainly due to CTX-M, is a major global public health problem. Patients infected with ESBL-producing gram-negative bacteria have an increased risk of treatment failure and death. We investigated the prevalence and risk factors for CTX-M gram-negative bacteria isolated from clinical specimens of patients hospitalized at a tertiary care hospital in Kilimanjaro, Tanzania. Isolated gram-negative bacteria from inpatients admitted at Kilimanjaro Christian Medical Centre (KCMC) between August 2013 and August 2015 were fully genome sequenced...
February 20, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Desmond Hsu, Mark Melzer
BACKGROUND AND AIM: In 2017, National Health Service Improvement set a 10% reduction target for Escherichia coli bacteraemia by 2018, followed by a 50% reduction in healthcare-associated Gram-negative bacteraemias by 2022. We analysed consecutive cases of E. coli bacteraemia and devised a strategy to achieve these targets. METHODS: From December 2012 to November 2013, demographic, clinical and microbiological data were prospectively collected on all patients with bacteraemia at the Royal London Hospital in East London, UK...
February 20, 2018: Postgraduate Medical Journal
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"