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extended spectrum beta lactamase

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https://www.readbyqxmd.com/read/29783023/extended-spectrum-beta-lactamase-producing-enterobacteriaceae-infections-in-haematopoietic-stem-cell-transplant-recipients-epidemiology-and-molecular-characterization
#1
Molka Kharrat, Yosra Chebbi, Farah Ben Tanfous, Amel Lakhal, Saloua Ladeb, Tarek Ben Othmen, Wafa Achour
BACKGROUND: Extended spectrum β-lactamase producing Enterobacteriaceae (ESBL-E) are feared because they generate therapeutic difficulties and have high potential for dissemination. The purpose of our study was to investigate the epidemiology of these infections in hematopoietic stem cell transplant (HSCT) recipients and to determine the genes encoding ESBL. MATERIAL/METHODS: Our retrospective study concerned adult patients hospitalized at the National Bone Marrow Transplant Center and infected with ESBL-E post HSCT between january 2006 and december 2016...
May 18, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29780833/the-growing-genetic-and-functional-diversity-of-extended-spectrum-beta-lactamases
#2
REVIEW
Sadeeq Ur Rahman, Tariq Ali, Ijaz Ali, Nazir Ahmad Khan, Bo Han, Jian Gao
The β -lactams-a large class of diverse compounds-due to their excellent safety profile and broad antimicrobial spectrum are considered to be the most widely used therapeutic class of antibacterials prescribed in human and veterinary clinical practices. This, unfortunately, has also given rise to a continuous increased resistance globally in health care settings as well as in the community due to their permanent selective force driving diversification of the resistance mechanism. Resistance against β -lactams is increasing rapidly as novel β -lactamases, enzymes that degrade β -lactams, are being discovered each day such as recent emergence of extended spectrum β -lactamases (ESBL) that have the ability to inactivate most of the cephalosporins...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29778819/detection-of-tem-and-ctx-m-genes-from-ciprofloxacin-resistant-proteus-mirabilis-and-escherichia-coli-isolated-on-urinary-tract-infections-utis
#3
Govindan Rajivgandhi, Muthuchamy Maruthupandy, Natesan Manoharan
The multidrug resistant Gram negative bacteria (MDRGNB) is an emerging burden and now represents a daily challenge for the management of antimicrobial therapy in healthcare settings. The present study was aimed to detect the prevalence of TEM and CTX-M type genes from GNB on urinary tract infection (UTIs). The ciprofloxacin resistant uropathogens were detected by HEXA UTI 5 disc diffusion method. The phenotypic detection of uropathogens producing extended spectrum beta lactamases (ESBLs) was confirmed by double disc combination (DDCT) and phenotype confirmation methods (PCT)...
May 17, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29778183/high-genetic-diversity-of-extended-spectrum-%C3%AE-lactamases-producing-escherichia-coli-in-feces-of-horses
#4
Syndia Sadikalay, Yann Reynaud, Stéphanie Guyomard-Rabenirina, Mélanie Falord, Célia Ducat, Laetitia Fabre, Simon Le Hello, Antoine Talarmin, Séverine Ferdinand
Extended-spectrum beta-lactamases (ESBLs), especially those of the CTX-M type, represent a major public health problem throughout the world. Although the carriage of ESBL-producing Enterobacteriaceae (EPE) in feces of horses is now well recognized, little is known about the diversity of EPE after treatment of horses with antibiotics. We undertook this study to assess and follow the diversity of EP Escherichia coli isolated from horses after antibiotic treatment for an infection. Fecal samples from two horses treated and two that were untreated were tested for the presence of EPE on different days...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29771318/novel-sequence-types-of-extended-spectrum-and-acquired-ampc-beta-lactamase-producing-escherichia-coli-and-escherichia-clade-v-isolated-from-wild-mammals
#5
Carla Andrea Alonso, Leticia Alcalá, Carmen Simón, Carmen Torres
No abstract text is available yet for this article.
June 1, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29771255/return-of-the-tetracyclines-omadacycline-a-novel-aminomethylcycline-antimicrobial
#6
J C Cho, L M Childs-Kean, M T Zmarlicka, M P Crotty
Omadacycline is a novel aminomethylcycline antimicrobial agent that is available in both oral and intravenous formulations. The distinguishing structural characteristics of omadacycline from other tetracyclines allow for its continued antimicrobial activity in the presence of traditional tetracycline resistance mechanisms (efflux pumps and ribosomal protection proteins). Omadacycline has been found to have potent activity against antibiotic-resistant pathogens including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, extended spectrum beta-lactamase-producing Escherichia coli and multidrug-resistant Streptococcus pneumoniae...
March 2018: Drugs of Today
https://www.readbyqxmd.com/read/29769010/evaluation-of-fosfomycin-activity-against-esbl-producing-enterobacteriaceae-isolated-from-iran
#7
Hossein Kazemian
BACKGROUND: Rising rates of antimicrobial resistance among Enterobacteriaceae limit the use of reliably active forms of available drugs. The aim of this study was to investigate the prevalence of fosfomycin (US6794490B2) resistance gene among ESBL producing isolates in Iran. METHOD: We tested 355 isolates of Enterobacteriacea collected from various clinical samples including urine, wounds, blood and other sources during June 2016 to July 2017. Antibiotic sensitivity and extended spectrum beta lactamase (ESBL) production were tested using agar dilution method according to the Clinical and Laboratory Standards Institute (CLSI) guidelines...
May 16, 2018: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/29761673/neonatal-risk-factors-for-colonization-with-extended-spectrum-beta-lactamase-producing-bacteria-in-the-neonatal-intensive-care-unit
#8
Viktoria Leikin-Zach, Eilon Shany, Maayan Yitshak-Sade, Ron Eshel, Tali Shafat, Avraham Borer, Rimma Melamed
BACKGROUND: Extended-spectrum beta-lactamase (ESBL) production is the most common antimicrobial resistance mechanism in the neonatal intensive care unit (NICU), with colonization and blood stream infections being a major threat to this population. Since 2013, all NICU admissions at our facility were screened twice weekly for ESBL colonization. OBJECTIVES: To determine independent risk factors for colonization of infants with ESBL-producing bacteria in the NICU. METHODS: A retrospective case study of ESBL-colonized infants vs...
May 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29757079/epidemiology-antimicrobial-resistance-and-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-in-clinical-bovine-mastitis-in-tunisia
#9
Mariem Saidani, Lilia Messadi, Alya Soudani, Monia Daaloul-Jedidi, Pierre Châtre, Faten Ben Chehida, Aymen Mamlouk, Wassim Mahjoub, Jean-Yves Madec, Marisa Haenni
Bovine mastitis is a major disease in dairy cattle that causes high economic losses annually. Staphylococci, streptococci, and coliforms are among the major pathogens responsible for such infections. While data on bovine mastitis are numerous in Europe where the efficacy of farm management was monitored, those are scarce in African countries. In this study, we reported the occurrence of Escherichia coli (118/372, 31.7%) and Klebsiella pneumoniae (77/372, 20.7%), two environmental pathogens known to cause bovine mastitis...
May 14, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29751120/evaluation-of-a-risk-guided-strategy-for-empiric-carbapenem-use-in-febrile-neutropenia
#10
Ai Leng Khoo, Ying Jiao Zhao, Monica Teng, Ding Ying, Jing Jin, Yen Lin Chee, Li Mei Poon, Siew Eng Lim, Liang Piu Koh, Wee Joo Chng, Boon Peng Lim, Li Yang Hsu, Louis Yi Ann Chai
Febrile neutropenia (FN) is associated with substantial morbidity and necessitate empiric broad spectrum antibiotic treatment. We evaluated a risk-guided FN management strategy using empiric piperacillin-tazobactam and carbapenem in a prospective cohort study. The analysis involved 723 FN episodes in hospitalised adult patients, including those with severe sepsis or prior infection/colonisation with extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae. Propensity score matching analysis was used to adjust for baseline differences between treatment groups and produced 267 matched pairs...
May 8, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29748922/defining-the-relationship-between-phenotypic-and-genotypic-resistance-profiles-of-multidrug-resistant-enterobacterial-clinical-isolates
#11
Lamis Galal, Neveen A Abdel Aziz, Walaa M Hassan
Fluoroquinolones and aminoglycosides offer effective therapy for extended-spectrum beta-lactamase (ESBL)-producing enterobacterial infections, but their usefulness is threatened by increasing resistant strains. OBJECTIVE: This study was conducted to demonstrate the phenotypic outcomes of the coexistence of genetic determinants mediating resistance to extended-spectrum cephalosporins and quinolones in enterobacterial isolates collected from patients with health-care-associated infections in Egypt...
May 11, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29748840/clinical-patterns-epidemiology-and-risk-factors-of-community-acquired-urinary-tract-infection-caused-by-extended-spectrum-beta-lactamase-producers-a-prospective-hospital-case-control-study
#12
Basima A Almomani, Wail A Hayajneh, Abeer M Ayoub, Mera A Ababneh, Miral A Al Momani
PURPOSE: To assess incidence rate, risk factors and susceptibility patterns associated with extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli or Klebsiella pneumoniae in community-acquired urinary tract infections (CA-UTIs). METHODS: A prospective, case-control study was conducted at a tertiary teaching hospital from Jan 2015 to Dec 2016. The results of microbiology cultures were initially screened to include only patients with positive E. coli or K...
May 10, 2018: Infection
https://www.readbyqxmd.com/read/29744322/dissemination-of-multidrug-resistant-class-i-and-ii-integrons-and-molecular-typing-of-ctx-m-producing-klebsiella-pneumoniae
#13
Alisha Akya, Azam Elahi, Roya Chegenelorestani, Mahya Rezaee
Introduction: Klebsiella pneumoniae ( K. pneumoniae ) is an important opportunistic pathogen causes serious community and hospital-acquired infections, which is highly resistant to antibiotics. We aimed to determine the frequency of multidrug resistant (MDR) and molecular typing of clinical isolates of K. pneumoniae . Methodology: One hundred isolates of K. pneumoniae were collected from clinical samples in three general hospitals in Kermanshah. The antimicrobial susceptibility and extended-spectrum beta-lactamases (ESBL) production of isolates were determined using disk diffusion and combined disk methods, respectively...
April 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29743768/epidemiological-analysis-of-extended-spectrum-beta-lactamase-producing-bacterial-infections-in-adult-live-donor-liver-transplant-patients
#14
Ajeet Singh, Deepak Govil, Usha Krishan Baveja, Anand Gupta, Neha Tandon, Shrikanth Srinivasan, Sachin Gupta, Sweta J Patel, Sanjiv Saigal, Arvinder Singh Soin
Introduction: Bacterial infections are a leading cause of morbidity and mortality in patients receiving solid-organ transplants. Extended-spectrum beta-lactamases (ESBL) pathogens are the most important pathogenic bacteria infecting these patients. Aim: This study aims to evaluate for the incidence and characteristics of ESBL-positive organism, to look for the clinical outcomes in ESBL-positive infected cases, and to evaluate and draft the antibiotic policy in posttransplant patients during the first 28 days posttransplant...
April 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29740989/activity-of-fosfomycin-against-nosocomial-multiresistant-bacterial-pathogens-from-croatia-a-multicentric-study
#15
Luka Bielen, Robert Likić, Viktorija Erdeljić, Ivana Mareković, Nataša Firis, Marijana Grgić-Medić, Ana Godan, Ivan Tomić, Blaženka Hunjak, Alemka Markotić, Danijela Bejuk, Vladimira Tičić, Silvana Balzar, Branka Bedenić
AIM: To determine in vitro susceptibility of multiresistant bacterial isolates to fosfomycin. METHODS: In this prospective in vitro study (local non-random sample, level of evidence 3), 288 consecutively collected multiresistant bacterial isolates from seven medical centers in Croatia were tested from February 2014 until October 2016 for susceptibility to fosfomycin and other antibiotics according to Clinical and Laboratory Standards Institute methodology. Susceptibility to fosfomycin was determined by agar dilution method, while disc diffusion was performed for in vitro testing of other antibiotics...
April 30, 2018: Croatian Medical Journal
https://www.readbyqxmd.com/read/29739004/detection-of-antibiotic-resistance-determinants-and-their-transmissibility-among-clinically-isolated-carbapenem-resistant-escherichia-coli-from-south-india
#16
Niranjana Mahalingam, Bhavani Manivannan, Balaram Khamari, Shivakumara Siddaramappa, Sudeshna Adak, Eswarappa Pradeep Bulagonda
OBJECTIVES: The aim of this study was to analyze the prevalence of CTX-M, TEM, SHV, VIM, NDM and OXA genes in carbapenemase-producing E. coli and their transmissibility at a tertiary care hospital in south India. MATERIALS AND METHODS: Twenty-one carbapenem-resistant E. coli (CRE) were collected from Sri Sathya Sai Institute of Higher Medical Sciences, Prasanthigram, India. Resistance to antibiotics was analyzed by Vitek-2, and identity of the isolates was confirmed by 16S rDNA sequencing...
May 8, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29738654/-multidrug-resistance-e-eskape-strains-isolated-from-blood-cultures-in-patients-with-cancer
#17
Consuelo Velázquez-Acosta, Patricia Cornejo-Juárez, Patricia Volkow-Fernández
OBJECTIVE: To describe the trend of multidrug resistant (MDR) strains isolated from blood in patients with cancer from 2005 to 2015. MATERIAL AND METHODS: 33 127 blood cultures were processed by retrospective analysis. Identification and antimicrobial sensitivity were performed through automated methods: WaLK away (Siemens Labora- tory Diagnostics) and BD Phoenix (Becton, Dickinson and Company). Resistant strains were determined according to the minimum inhibitory concentration, following the parameters of the Clinical and Laboratory Standards Institute (CLSI)...
March 2018: Salud Pública de México
https://www.readbyqxmd.com/read/29737191/the-association-between-extended-spectrum-beta-lactamase-esbl-and-ampicillin-c-ampc-beta-lactamase-genes-with-multidrug-resistance-in-escherichia-coli-isolates-recovered-from-turkeys-in-brazil
#18
Patrícia Giovana Hoepers, Paulo Lourenço Silva, Daise Aparecida Rossi, Edson Campos Valadares Júnior, Bruna Custódio Ferreira, João Paulo Zuffo, Priscilla Karina Koerich, Belchiolina Beatriz Fonseca
ABSTRACT- 1. The aim of this study was to analyse the association between Escherichia coli isolates recovered from turkeys and the expression of beta-lactamase genes, such as extended spectrum beta lactamase (ESBL) and ampicillin class C (AmpC). The phenotype of the resistance profile was examined using the association between amoxicillin and ceftiofur resistance. 2. Results showed that 84% from the turkey isolates harboured four or five genes associated with the CoIV plasmid. In an antibiogram test, 82% of the isolates were multi-drug resistant (MDR), the highest levels of resistance being against erythromycin (99%) and amoxicillin (76...
May 8, 2018: British Poultry Science
https://www.readbyqxmd.com/read/29737104/-antibiotic-resistance-and-risk-factors-for-mortality-of-blood-stream-infections-bsis-with-escherichia-coli-in-patients-with-hematological-malignancies
#19
Wei-Li Zhang, Jie Huang, Si-Ying Wu, Ya Liu, Fang Long, Yu-Ling Xiao, Yi Xie, Chao He, Mei Kang
OBJECTIVE: To analyze the risk factors for mortality of blood stream infections (BSIs) caused by Escherichia coli in the patients with hematological malignancies. METHODS: There were 110 Escherichia coli BSIs patients with hematological malignancies included in recent five years. Among them,77 cases had BSIs caused by extended-spectrum-beta-lactamase (ESBL)-producing Escherichia coli (ESBL-EC group),while 33 cases had BSIs with non-ESBL-producing Escherichia coli (non-ESBL-EC group)...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29735825/high-level-aminoglycoside-resistance-in-acinetobacter-baumannii-recovered-from-intensive-care-unit-patients-in-northeastern-india
#20
Supriya Upadhyay, Annie Bakorlin Khyriem, Prithwis Bhattacharya, Amitabha Bhattacharjee, Santa Ram Joshi
Background: Acinetobacter baumannii has emerged as an important nosocomial pathogen, its ability to acquire resistance to carbapenems and aminoglycosides, has complicated their treatment regimen. The present study investigates the prevalence and diversity of aminoglycoside-modifying enzymes and 16S methyltransferases in A. baumannii isolates recovered from patients admitted in Intensive Care Unit (ICU) of a tertiary referral hospital in Northeastern India. Materials and Methods: We investigated the high-level aminoglycoside-resistance (HLAR) (gentamicin and amikacin minimum inhibitory concentration ≥ 512 μg/ml) among 164 multidrug-resistant A...
January 2018: Indian Journal of Medical Microbiology
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