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extended spectrum beta lactamase

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https://www.readbyqxmd.com/read/28630686/fecal-carriage-of-extended-spectrum-%C3%AE-lactamase-and-carbapenemase-producing-enterobacteriaceae-in-egyptian-patients-with-community-onset-gastrointestinal-complaints-a-hospital-based-cross-sectional-study
#1
H M Abdallah, N Alnaiemi, E A Reuland, B B Wintermans, A Koek, A M Abdelwahab, A Samy, K W Abdelsalam, C M J E Vandenbroucke-Grauls
OBJECTIVES: The aim of this study was to determine the prevalence of extended-spectrum β-lactamase (ESBL) and carbapenemase production among Enterobacteriaceae isolated from ambulatory patients with gastrointestinal complaints admitted to El-Ahrar General Hospital, Zagazig, Egypt in the period between January 2013 and May 2013. METHODS: One hundred and thirteen Enterobacteriaceae isolates were recovered from 100 consecutive Egyptian patients with community-onset gastrointestinal complaints...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28630197/pharmacodynamics-of-cefepime-combined-with-tazobactam-against-clinically-relevant-enterobactereaceae-in-a-neutropenic-mouse-thigh-model
#2
Maria J Melchers, Anita C van Mil, Claudia Lagarde, Jan den Hartigh, Johan W Mouton
The lack of new antibiotics prompted the investigation of the combination of two existing agents cefepime, a broad-spectrum cephalosporin and tazobactam to broaden its efficacy against extended-spectrum beta-lactamase producing Enterobacteriaceae. We determined the pharmacokinetic and pharmacodynamic properties of the combination in a murine neutropenic thigh model in order to establishing its exposure- response relationships (ERR). The PK of cefepime was determined for five doses; that of tazobactam was determined in earlier studies (Melchers et al Antimicrob...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28626539/resistance-to-colistin-in-klebsiella-pneumoniae-a-4-0-strain
#3
REVIEW
Guido Granata, Nicola Petrosillo
The global rise of multidrug-resistant gram-negative bacteria represents an increasing threat to patient safety. From the first observation of a carbapenem-resistant gram-negative bacteria a global spread of extended-spectrum beta-lactamases and carbapenemases producing Klebsiella pneumoniae has been observed. Treatment options for multidrug-resistant K. pneumoniae are actually limited to combination therapy with some aminoglycosides, tigecycline and to older antimicrobial agents. Unfortunately, the prevalence of colistin-resistant and tigecycline-resistant K...
May 31, 2017: Infectious Disease Reports
https://www.readbyqxmd.com/read/28619802/draft-genome-sequences-of-extended-spectrum-beta-lactamase-producing-morganella-morganii-strains-aa1-and-av1-isolated-from-a-freshwater-lake-and-eicchorniacrassipes-roots
#4
Pushpa Lata, Subramaniam S Govindarajan, Feng Qi, Jian-Liang Li, Santosh K Maurya, Malaya K Sahoo
Two strains of Morganella morganii, AA1 and AV1, were isolated from freshwater and Eicchornia crassipes roots, respectively. Here, we report their draft genome sequences, which are ~3.6 Mb and have 51% G+C content. The predicted coding sequences (3,259 for strain AA1 and 3,345 for strain AV1) encode beta-lactamases, transpeptidases, and penicillin-binding proteins.
June 15, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28608133/frequency-associated-factors-and-outcome-of-multi-drug-resistant-intensive-care-unit-acquired-pneumonia-among-patients-colonized-with-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae
#5
Keyvan Razazi, Armand Mekontso Dessap, Guillaume Carteaux, Chloé Jansen, Jean-Winoc Decousser, Nicolas de Prost, Christian Brun-Buisson
BACKGROUND: We assessed prevalence, associated factors and prognosis of extended-spectrum beta-lactamase-producing Enterobacteriaceae pneumonia acquired in intensive care unit (ESBL-PE pneumonia) among carriers. Variables associated with nosocomial pneumonia caused by carbapenem-resistant bacteria (CRB) were also assessed. METHODS: A 6-year prospective study (May 2009-March 2015) in the medical ICU of an 850-bed university-affiliated hospital was conducted. RESULTS: Of the 6303 patients admitted, 843 (13...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28604274/routine-prophylactic-antimicrobial-use-is-associated-with-increased-phenotypic-and-genotypic-resistance-in-commensal-escherichia-coli-isolates-recovered-from-healthy-fattening-pigs-on-farms-in-thailand
#6
Kittitat Lugsomya, Thanitta Chatsuwan, Waree Niyomtham, Padet Tummaruk, David J Hampson, Nuvee Prapasarakul
This study examined antimicrobial resistance (AMR) profiles in commensal Escherichia coli derived from healthy fattening pigs in Thai farms that used prophylactic antimicrobials (in-feed tiamulin fumarate and amoxicillin) [PAs], therapeutic antimicrobials (injectable enrofloxacin or gentamicin) [TAs], or no antimicrobials [NAs]. Commensal E. coli were used as a proxy for overall AMR on the farms. There was a high level of multidrug resistance in all three categories of farm, with isolates showing resistance to β-lactams (amoxicillin, ampicillin, and piperacillin) and tetracyclines (tetracycline), and commonly possessing tetA, blaTEM, and plasmid replicons FIB and F...
June 12, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28602703/clinical-predictors-and-outcomes-of-klebsiella-pneumoniae-bacteraemia-in-a-regional-hospital-in-hong-kong
#7
M Y Man, H P Shum, Y H Chan, K C Chan, W W Yan, R A Lee, S K P Lau
BACKGROUND: Klebsiella pneumoniae (KP) infection is associated with high morbidity and mortality. Multidrug resistance, especially extended spectrum beta-lactamase (ESBL) production, in KP is endemic worldwide. Our study aimed to evaluate the clinical characteristics and outcomes of patients with KP bacteraemia in critical care and general ward settings. METHODS: Adult patients admitted to a regional hospital in Hong Kong from 1 January 2009 to 30 June 2016 (7.5 years) with KP bacteraemia were included...
June 8, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28600076/the-contribution-and-limits-of-clinical-specimens-for-the-screening-of-intestinal-multidrug-resistant-bacteria-in-view-of-laboratory-automation
#8
Geraud De Galassus Alix, Florence Cizeau, Aurélie Agathine, Cecilia Domrane, David Ducellier, Vincent Fihman, Jean-Winoc Decousser
The detection of multidrug-resistant bacteria carriers constitutes a race against time for infection preventionists. Alongside standard analysis for diagnosis purposes and rectal screening strategy, we tested a heavy-loaded selective method against 562 clinical specimens from 439 patients to detect extended-spectrum beta-lactamase-producing (ESBL) or carbapenemase-producing Enterobacteriaceae (CPE) and vancomycin-resistant enterococci (VRE). Our approach identified five more specimens positive for ESBL-producing Enterobacteriaceae than standard analysis, and 6 out of 9 known VRE/CPE carriers (three new CPE/VRE strains were also identified in this cohort)...
June 6, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28592240/randomized-controlled-trial-of-piperacillin-tazobactam-cefepime-and-ertapenem-for-the-treatment-of-urinary-tract-infection-caused-by-extended-spectrum-beta-lactamase-producing-escherichia-coli
#9
Yu Bin Seo, Jacob Lee, Young Keun Kim, Seung Soon Lee, Jeong-A Lee, Hyo Youl Kim, Young Uh, Han-Sung Kim, Wonkeun Song
BACKGROUND: Due to limited therapeutic options, the spread of extended-spectrum beta-lactamases (ESBLs) have become a major public health concern. We conducted a prospective, randomized, open-label comparison of the therapeutic efficacy of piperacillin-tazobactam (PTZ), cefepime, and ertapenem in febrile nosocomial urinary tract infection with ESBL-producing Escherichia coli (ESBL-EC). METHODS: This study was conducted at three university hospitals between January 2013 and August 2015...
June 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28582313/outbreaks-in-the-neonatal-icu-a-review-of-the-literature
#10
Julia Johnson, Caroline Quach
PURPOSE OF REVIEW: Neonates in the neonatal ICU (NICU) are uniquely vulnerable to colonization and infection with pathogens such as multidrug resistant Gram-negative bacteria, which in turn are associated with increased infection-related morbidities and higher case-fatality rates. We reviewed the English, French, and German language literature published between 2015 and 2017, for reports of NICU outbreaks. RECENT FINDINGS: A total of 39 outbreaks in NICUs were reported with Gram-negative bacteria (n = 21; 54%) causing most, and extended spectrum beta-lactamase-producing organisms being the most frequent resistance mechanism reported (n = 5)...
June 2, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28578094/salmonella-heidelberg-genetic-profile-of-its-antimicrobial-resistance-related-to-extended-spectrum-%C3%AE-lactamases-esbls
#11
Jéssica Giuriatti, Lenita Moura Stefani, Maiara Cristina Brisola, Regiane Boaretto Crecencio, Dinael Simão Bitner, Gláucia Amorim Faria
The objective of this study was to evaluate the phenotypic and genotypic profile of antimicrobial susceptibility and the possible involvement of extended spectrum beta-lactamases (ESBLs) in the resistance profile of Salmonella Heidelberg (SH) isolated from chicken meat. We used 18 SH isolates from chicken meat produced in 2013 in the state of Paraná, Southern Brazil. The isolates were submitted to disk-diffusion tests and from these results it was possible to determine the number of isolates considered multiresistant and the index of multiple antimicrobial resistance (IRMA) against ten antimicrobials routinely used in human and veterinary medicine...
May 31, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28573605/inhibitory-effect-of-biosynthesized-silver-nanoparticles-from-extract-of-nitzschia-palea-against-curli-mediated-biofilm-of-escherichia-coli
#12
Rajamohamed Beema Shafreen, Siddharthan Seema, Abdulazees Parveez Ahamed, Nooruddin Thajuddin, Sulaiman Ali Alharbi
Extended spectrum beta lactamase (ESBL) are emerging beta-lactamases in Gram-negative pathogens, causing serious problems in hospitalized patients worldwide. Biofilm mode of virulence has decreased the efficiency of antibiotics used for treatment against ESBL pathogens. Therefore, there is an urgent need for alternative agents such as nanoparticles that can prevent and inhibit the biofilm formation. The aim of the present study was to inhibit the biofilm formed by ESBL-producing Escherichia coli using silver nanoparticles (AgNPs) synthesized with fresh water diatom (Nitzschia palea)...
June 1, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28552890/collaborative-research-on-puerperal-infections-in-bangladesh
#13
Nobumichi Kobayashi, Salma Ahmed, Ayako Sumi, Noriko Urushibara, Mitsuyo Kawaguchiya, Meiji Soe Aung
Bangladesh is considered as a high-risk country for emerging infectious diseases because of its high population density, poverty, and unhygienic conditions. Although control efforts have primarily been focused on major infectious diseases such as diarrheal diseases, tuberculosis, malaria, and HIV infection, the prevalence and impact of many local or minor infectious diseases are still unclarified in this country. In this review, we present our recent experience and outcomes of collaborative research on puerperal infection (PI), which is a poorly defined infectious disease in Bangladesh...
2017: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
https://www.readbyqxmd.com/read/28551912/-bacteria-without-borders-a-high-carriage-rate-of-antibiotic-resistant-bacteria-among-syrian-children-hospitalized-in-galilee-medical-center
#14
Diana Faour Kassem, Naama Shahar, Smadar Ocampo, Tarif Bader, Zeev Zonis, Daniel Glikman
INTRODUCTION: As the civil war in Syria enters its fifth year, the Israeli government continues to provide humanitarian aid to Syrian civilians in Israeli hospitals. Many wounded Syrian children are treated at the Galilee Medical Center (GMC). Due to the patients' incomplete medical history and increasing infection rates in Syria, contact isolation and screening cultures for multi-drug resistant bacteria (MDR's) are conducted upon admission for all Syrian children. AIMS: To describe the rate of MDR carriage in Syrian children and compare it to hospitalized Israeli children...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28545484/timing-of-appropriate-empirical-antimicrobial-administration-and-outcome-of-adults-with-community-onset-bacteremia
#15
Ching-Chi Lee, Chung-Hsun Lee, Ming-Yuan Hong, Hung-Jen Tang, Wen-Chien Ko
BACKGROUND: Early administration of appropriate antimicrobials has been correlated with a better prognosis in patients with bacteremia, but the optimum timing of early antibiotic administration as one of the resuscitation strategies for severe bacterial infections remains unclear. METHODS: In a retrospective cohort study, adults with community-onset bacteremia at the emergency department (ED) were analyzed. Effects of different cutoffs of time to appropriate antibiotic (TtAa) administration after arrival at the ED on 28-day mortality were examined, after adjustment for independent predictors of mortality identified by multivariate regression analysis...
May 26, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28538846/-clinical-and-microbiological-study-of-catheter-associated-urinary-tract-infections-in-internal-medicine-services-of-a-venezuelan-university-hospital
#16
Pedro Quijada-Martínez, Ana Flores-Carrero, Indira Labrador, María Araque
Objectives: To determine the clinical and microbiological characteristics of catheter-associated urinary tract infections (CA-UTI) in patients admitted to the Internal Medicine services of the Hospital Universitario de Los Andes (HULA), Mérida, Venezuela and to establish the clonal distribution of multi-resistant Enterobacteriaceae that produce this infection. Materials and Methods: Seventy-three adult patients with bladder catheterization were studied between January and July 2015...
January 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28528936/efficacy-of-non-carbapenem-antibiotics-for-pediatric-patients-with-first-febrile-urinary-tract-infection-due-to-extended-spectrum-beta-lactamase-producing-escherichia-coli
#17
Yoshifusa Abe, Işil Inan-Erdogan, Kunihiko Fukuchi, Hitomi Wakabayashi, Yasuha Ogawa, Satoshi Hibino, Shunsuke Sakurai, Kazuhiko Matsuhashi, Yoshitaka Watanabe, Kaori Hashimoto, Kazuhisa Ugajin, Kazuo Itabashi
Although carbapenem is the recommended for urinary tract infection (UTI) caused by extended-spectrum beta-lactamase (ESBL)-producing organisms, non-carbapenems have been reported to be effective for adult patients with UTI caused by ESBL-producing organisms. The purpose of this study was to evaluate the efficacy of non-carbapenems for pediatric patients with UTI due to ESBL-producing Escherichia coli (E. coli) based on the microbiologic and clinical outcomes. Fifteen children, who were treated for first febrile UTI caused by ESBL-producing E...
May 18, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28520999/travel-acquired-esbl-producing-enterobacteriaceae-impact-of-colonization-at-individual-and-community-level
#18
Paul-Louis Woerther, Antoine Andremont, Anu Kantele
Background: Antibiotic resistance is a rapidly increasing global emergency that calls for action from all of society. Intestinal multidrugresistant (MDR) bacteria have spread worldwide with extended-spectrum beta-lactamase (ESBL) -producing Enterobacteriaceae (ESBL-PE) as the most prevalent type. The millions of travelers annually visiting regions with poor hygiene contribute substantially to this spread. Our review explores the underlying data and discusses the consequences of the colonization...
April 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28515902/sites-of-colonization-in-hospitalized-patients-with-infections-caused-by-extended-spectrum-beta-lactamase-organisms-a-prospective-cohort-study
#19
Zeina A Kanafani, Sukayna M Fadlallah, Sarah Assaf, Khalil Anouti, Kohar Annie B Kissoyan, Jad Sfeir, Tamara Nawar, Mohamad Yasmin, Ghassan M Matar
BACKGROUND: The objective of this study was to determine whether patients infected with extended-spectrum beta-lactamase (ESBL)-producing organisms are colonized at multiple body sites. METHODS: This was a prospective cohort study at a tertiary care center in Beirut, Lebanon. Hospitalized patients with infections caused by ESBL-producing organisms were included. Cultures were obtained from the primary site of infection as well as from other sites (skin, nasopharynx, urine, rectum)...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28513576/biofilm-is-a-major-virulence-determinant-in-bacterial-colonization-of-chronic-skin-ulcers-independently-from-the-multidrug-resistant-phenotype
#20
Enea Gino Di Domenico, Ilaria Farulla, Grazia Prignano, Maria Teresa Gallo, Matteo Vespaziani, Ilaria Cavallo, Isabella Sperduti, Martina Pontone, Valentina Bordignon, Laura Cilli, Alessandra De Santis, Fabiola Di Salvo, Fulvia Pimpinelli, Ilaria Lesnoni La Parola, Luigi Toma, Fabrizio Ensoli
Bacterial biofilm is a major factor in delayed wound healing and high levels of biofilm production have been repeatedly described in multidrug resistant organisms (MDROs). Nevertheless, a quantitative correlation between biofilm production and the profile of antimicrobial drug resistance in delayed wound healing remains to be determined. Microbial identification, antibiotic susceptibility and biofilm production were assessed in 135 clinical isolates from 87 patients. Gram-negative bacteria were the most represented microorganisms (60...
May 17, 2017: International Journal of Molecular Sciences
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