Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Nick Meier, Marie Warrer Munch, Anders Granholm, Anders Perner, Frederik Boëtius Hertz, Balasubramanian Venkatesh, Naomi E Hammond, Qiang Li, Liesbet De Bus, Jan De Waele, Evaldas Kauzonas, Fredrik Sjövall, Morten Hylander Møller, Marie Helleberg
BACKGROUND: Critically ill patients in intensive care units (ICU) are frequently administered broad-spectrum antibiotics (e.g., carbapenems or piperacillin/tazobactam) for suspected or confirmed infections. This retrospective cohort study aimed to describe the use of carbapenems and piperacillin/tazobactam in two international, prospectively collected datasets. METHODS: We conducted a post hoc analysis of data from the "Adjunctive Glucocorticoid Therapy in Patients with Septic Shock" (ADRENAL) trial (n = 3713) and the "Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure" (DIANA) study (n = 1488)...
March 28, 2024: Acta Anaesthesiologica Scandinavica
#2
JOURNAL ARTICLE
Maggie Wong, Sangita Malhotra, Kevin Afra
We describe our experience with intravenous amoxicillin-clavulanate, which is new to the Canadian market. The majority of patients were successfully de-escalated from piperacillin-tazobactam or a carbapenem for respiratory infections or skin and soft tissue infections. Intravenous amoxicillin-clavulanate provides a good alternative in an era of rising Pseudomonas aeruginosa resistance.
2024: Antimicrob Steward Healthc Epidemiol
#3
JOURNAL ARTICLE
Ana M de Matos, Patrícia Calado, Mónica Miranda, Rita Almeida, Amélia P Rauter, M Conceição Oliveira, Vera Manageiro, Manuela Caniça
The escalating antimicrobial resistance crisis urges the development of new antibacterial treatments with innovative mechanisms of action, particularly against the critical priority carbapenem-resistant Acinetobacter baumannii (CRAB), Pseudomonas aeruginosa (CRPA) and Enterobacteriaceae (CRE). Membrane-disrupting dodecyl deoxyglycosides have been reported for their interesting phosphatidylethanolamine-associated bactericidal activity against Gram-positive strains; however, their inability to penetrate the Gram-negative outer membrane (OM) renders them useless against the most challenging pathogens...
January 26, 2024: Scientific Reports
#4
JOURNAL ARTICLE
Takanobu Hoshi, Satoshi Fujii, Kei Watanabe, Yuta Fukumura, Koji Miyazaki, Madoka Takahashi, Sakae Taniguchi, Shingo Kimura, Arisa Saito, Naoki Wada, Masaji Saijo, Kazunori Yamada, Kuninori Iwayama, Marie Itaya, Hideki Sato
Carbapenems are antimicrobial agents commonly used to treat extended-spectrum β-lactamase (ESBL)-producing bacteria. Although cefmetazole (CMZ) is considered effective for ESBL-producing Escherichia coli (ESBL-EC) bacteremia, previous studies showed its limitations, including the influence of the initial antimicrobial agent. Here, we examined the effects of different approaches to antimicrobial therapy with CMZ and meropenem (MEPM) on the time to defervescence in ESBL-EC bacteremia. Notably, the influence of previous antimicrobial agents was excluded...
December 27, 2023: Infectious Disease Reports
#5
JOURNAL ARTICLE
Claire Durand, Karine Risso, Michael Loschi, Nicolas Retur, Audrey Emery, Johan Courjon, Thomas Cluzeau, Michel Carles
BACKGROUND: The 4th European Conference on Infections in Leukemia recommends early adaptation of empirical antibiotic therapy (EAT) for febrile neutropenia in stable patients. OBJECTIVES: To assess the efficacy of an antimicrobial stewardship (AMS) intervention promoting early de-escalation and discontinuation of EAT in high-risk neutropenic patients. METHODS: This before-after study was conducted in the hematology department of the University Hospital of Nice, France...
January 17, 2024: Antimicrobial Resistance and Infection Control
#6
MULTICENTER STUDY
François Barbier, Claire Dupuis, Niccolò Buetti, Carole Schwebel, Élie Azoulay, Laurent Argaud, Yves Cohen, Vivien Hong Tuan Ha, Marc Gainnier, Shidasp Siami, Jean-Marie Forel, Christophe Adrie, Étienne de Montmollin, Jean Reignier, Stéphane Ruckly, Jean-Ralph Zahar, Jean-François Timsit
KEY MESSAGES: In this study including 391 critically ill patients with nosocomial pneumonia due to Gram-negative pathogens, combination therapy was not associated with a reduced hazard of death at Day 28 or a greater likelihood of clinical cure at Day 14. No over-risk of AKI was observed in patients receiving combination therapy. BACKGROUND: The benefits and harms of combination antimicrobial therapy remain controversial in critically ill patients with hospital-acquired pneumonia (HAP), ventilated HAP (vHAP) or ventilator-associated pneumonia (VAP) involving Gram-negative bacteria...
January 3, 2024: Critical Care: the Official Journal of the Critical Care Forum
#7
JOURNAL ARTICLE
Nitin Bansal, Neelam Sachdeva, Dinesh Bhurani, Narendra Agarwal, Rayaz Ahmed, Pallavi Mehta, Rohan Halder
INTRODUCTION: Carbapenem-resistant Enterobacteriaceae (CRE) infections are associated with poor outcomes, particularly among hematology-oncology patients. Appropriate use (selection and de-escalation) of antibiotics is a key component of management of febrile neutropenia particularly in high CRE prevalence regions like India. METHODS: This was a retrospective study done (April 2019-December 2021) in a dedicated oncology center in North India, which assessed the case records of the patients undergoing therapy for hematological malignancies who were diagnosed with CRE bacteremia...
September 2023: Germs
#8
JOURNAL ARTICLE
Nisrine Haddad, Rony M Zeenny, Celia El Halabi, Tamara Abdallah, Remie El Helou, Nada Kara Zahreddine, Souha S Kanj, Nesrine A Rizk
BACKGROUND: Antimicrobial Resistance, a global concern, worsened with the COVID-19 pandemic that caused a surge of critically ill patients, increased antimicrobial consumption, and the spread of infections with multidrug-resistant organisms (MDROs). Antimicrobial Stewardship Programs (ASP) aim to optimize antimicrobial utilization to fight resistance. We aim to describe the ASP experience and to study antimicrobial consumption and MDRO rates among COVID-19 patients at a tertiary care center in Beirut...
December 14, 2023: Journal of Infection and Public Health
#9
César Ricardo Coimbra de Matos, Eduarda Maria da Conceição Sério Pereira Beirão, Rafael Simões Neves, António José Assunção, Rui Moreira Marques
BACKGROUND: Neuroleptic malignant syndrome (NMS) is a neurologic emergency potentially fatal. This rare side effect is most commonly associated with first-generation antipsychotics and less frequently with atypical or second-generation antipsychotics. The diagnosis relies on both clinical and laboratory criteria, with other organic and psychiatric conditions being ruled out. CASE REPORT: A 39-year-old female patient, who is institutionalized and completely dependent, has a medical history of recurrent urinary infections and colonization by carbapenem-resistant Klebsiella pneumoniae...
2023: São Paulo Medical Journal
#10
JOURNAL ARTICLE
Sofie C M Tops, Claire E P Schapendonk, Jordy P M Coolen, Fred C Tenover, Isabella A Tickler, Willem J G Melchers, Heiman F L Wertheim
Early identification of complicated urinary tract infections caused by ESBL-producing Enterobacterales has the potential to limit the use of carbapenems to those patients without alternative antibiotic options and avoid the empirical use of carbapenems in patients without ESBL-producing bacteria. The purpose for such a test will differ by setting and ESBL prevalence rates. Countries with low ESBL rates and cephalosporins as empiric treatment (e.g., The Netherlands) will need a rule-in test to decide to use carbapenems, while countries with high ESBL rates and empiric carbapenem treatment will need a rule-out test for ESBLs to de-escalate therapy early...
November 14, 2023: Microbiology Spectrum
#11
JOURNAL ARTICLE
Surendran Rajendran, Ram Gopalakrishnan, Anil Tarigopula, D Suresh Kumar, P Senthur Nambi, Nandini Sethuraman, Chitra Chandran, Nagarajan Ramakrishnan, V Ramasubramanian
INTRODUCTION AND BACKGROUND: Rapid molecular diagnostics to predict carbapenem resistance well before the availability of routine drug sensitivity testing (DST) can serve as an antimicrobial stewardship tool in the context of high rates of Carbapenem-resistant Enterobacteriaceae (CRE). MATERIALS AND METHODS: A retrospective observational study of patients more than 18 years of age on whom Xpert Carba-R (FDA approved for rectal swab specimen) was done on gram-negative bacteria (GNB) flagged blood culture samples, in an Indian intensive care unit between January 2015 and November 2018...
September 2023: Indian Journal of Critical Care Medicine
#12
JOURNAL ARTICLE
Jin Sae Yoo, Jeong Yong Park, Ha-Jin Chun, Young Rong Kim, Eun Jin Kim, Young Hwa Choi, Kyoung Hwa Ha, Jung Yeon Heo
This study aimed to assess the impact of a prolonged carbapenem use-focused antimicrobial stewardship program (ASP) on antimicrobial consumption and clinical outcomes and to analyze factors affecting adherence to interventions. Patients prescribed carbapenems for ≥ 2 weeks received intervention. Interrupted time-series analysis was performed to compare antimicrobial consumption before and after intervention. Factors associated with non-adherence to intervention were investigated. Of 273 patients who were eligible for intervention, discontinuation or de-escalation was recommended in 256 (94...
September 4, 2023: Scientific Reports
#13
JOURNAL ARTICLE
Maria Batlle, Josep M Badia, Sergi Hernández, Santiago Grau, Ariadna Padulles, Lucía Boix-Palop, Montserrat Giménez-Pérez, Ricard Ferrer, Esther Calbo, Enric Limón, Miquel Pujol, Juan P Horcajada
BACKGROUND: Guidelines recommend 5-7 days of antibiotic treatment in patients with surgical infection and adequate source control. This nationwide stewardship intervention aimed to reduce the duration of treatments in surgical patients to <7 days. METHODS: Prospective cohort study evaluating surgical patients receiving antibiotics ≥7 days in 32 hospitals. Indication for treatment, quality of source control, type of recommendations issued, and adherence to the recommendations were analysed...
November 2023: International Journal of Antimicrobial Agents
#14
JOURNAL ARTICLE
Chonlanan Wiboonchutikula, Hong Bin Kim, Hitoshi Honda, Audrey Yong Xin Loo, Vincent Chi-Chung Cheng, Bernard Camins, Kittiya Jantarathaneewat, Piyaporn Apisarnthanarak, Sasinuch Rutjanawech, Anucha Apisarnthanarak
OBJECTIVE: To evaluate antibiotic prescribing behavior (APB) among physicians with various specialties in five Asian countries. DESIGN: Survey of antibiotics prescribing behavior in three stages (initial, on-treatment, and de-escalation stages). METHODS: Participants included internists, infectious diseases (ID) specialists, hematologists, intensivists, and surgeons. Participants' characteristics, patterns of APB, and perceptions of antimicrobial stewardship were collected...
2023: Antimicrob Steward Healthc Epidemiol
#15
JOURNAL ARTICLE
Anitha Ramadas, Rahela Ambaras Khan, Khairil Erwan Khalid, Chee Loon Leong, Mohd Makmor-Bakry
BACKGROUND: Antimicrobial stewardship (AMS) program aims to optimise antimicrobial utilisation and curb antimicrobial resistance. We investigated the clinical impact of AMS among patients with carbapenem in medical wards of a tertiary hospital. METHODS: A retrospective cohort study was conducted on hospitalised adult patients treated with carbapenem and reviewed by a multidisciplinary AMS team. We compared the clinical outcomes of accepted (n = 103) and not-accepted AMS intervention cases (n = 37)...
July 24, 2023: Journal of Pharmaceutical Policy and Practice
#16
JOURNAL ARTICLE
Yu Mi Wi, Ki Tae Kwon, Cheon-Hoo Jeon, Si-Ho Kim, Soyoon Hwang, Sohyun Bae, Yoonjung Kim, Hyun-Ha Chang, Shin-Woo Kim, Hae Suk Cheong, Shinwon Lee, Dong Sik Jung, Kyung Mok Sohn, Chisook Moon, Sang Taek Heo, Bongyoung Kim, Mi Suk Lee, Jian Hur, Jieun Kim, Young Kyung Yoon, Antimicrobial Stewardship Research Committee Of Korean Society For Antimicrobial Therapy
The appropriate use of carbapenem is a critical concern for patient safety and public health, and is a national priority. We investigated the nationwide status of carbapenem prescription in patients within their last 14 days of life to guide judicious-use protocols from the previous study comprised of 1350 decedents. Carbapenem use was universally controlled through computerised authorisation system at all centres during the study period. Carbapenem prescribing patterns and their optimality were evaluated. A total of 1201 patients received antimicrobial agents within the last two weeks of their lives, of whom 533 (44...
May 26, 2023: Antibiotics
#17
JOURNAL ARTICLE
Neal J Russell, Wolfgang Stöhr, Nishad Plakkal, Aislinn Cook, James A Berkley, Bethou Adhisivam, Ramesh Agarwal, Nawshad Uddin Ahmed, Manica Balasegaram, Daynia Ballot, Adrie Bekker, Eitan Naaman Berezin, Davide Bilardi, Suppawat Boonkasidecha, Cristina G Carvalheiro, Neema Chami, Suman Chaurasia, Sara Chiurchiu, Viviane Rinaldi Favarin Colas, Simon Cousens, Tim R Cressey, Ana Carolina Dantas de Assis, Tran Minh Dien, Yijun Ding, Nguyen Trong Dung, Han Dong, Angela Dramowski, Madhusudhan Ds, Ajay Dudeja, Jinxing Feng, Youri Glupczynski, Srishti Goel, Herman Goossens, Doan Thi Huong Hao, Mahmudul Islam Khan, Tatiana Munera Huertas, Mohammad Shahidul Islam, Daniel Jarovsky, Nathalie Khavessian, Meera Khorana, Angeliki Kontou, Tomislav Kostyanev, Premsak Laoyookhon, Sorasak Lochindarat, Mattias Larsson, Maia De Luca, Surbhi Malhotra-Kumar, Nivedita Mondal, Nitu Mundhra, Philippa Musoke, Marisa M Mussi-Pinhata, Ruchi Nanavati, Firdose Nakwa, Sushma Nangia, Jolly Nankunda, Alessandra Nardone, Borna Nyaoke, Christina W Obiero, Maxensia Owor, Wang Ping, Kanchana Preedisripipat, Shamim Qazi, Lifeng Qi, Tanusha Ramdin, Amy Riddell, Lorenza Romani, Praewpan Roysuwan, Robin Saggers, Emmanuel Roilides, Samir K Saha, Kosmas Sarafidis, Valerie Tusubira, Reenu Thomas, Sithembiso Velaphi, Tuba Vilken, Xiaojiao Wang, Yajuan Wang, Yonghong Yang, Liu Zunjie, Sally Ellis, Julia A Bielicki, A Sarah Walker, Paul T Heath, Mike Sharland
BACKGROUND: There is limited data on antibiotic treatment in hospitalized neonates in low- and middle-income countries (LMICs). We aimed to describe patterns of antibiotic use, pathogens, and clinical outcomes, and to develop a severity score predicting mortality in neonatal sepsis to inform future clinical trial design. METHODS AND FINDINGS: Hospitalized infants <60 days with clinical sepsis were enrolled during 2018 to 2020 by 19 sites in 11 countries (mainly Asia and Africa)...
June 2023: PLoS Medicine
#18
JOURNAL ARTICLE
Clara Cebron, Mina Smiljkovic, Lucas Percheron, Yvan Caspar, Julie Arata-Bardet, Guillaume Mortamet, Marie Martinod
BACKGROUND: This study aimed to describe the use of carbapenems in a pediatric tertiary center and to assess its compliance with national and local guidelines. METHODS: This retrospective study focused on children who received at least one dose of carbapenems in a tertiary university hospital over a 1-year period (2019). The appropriateness of each prescription was assessed. RESULTS: In total, 96 prescriptions were collected for 75 patients (median age 3 years [interquartile range, IQR: 0-9])...
June 5, 2023: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
#19
REVIEW
David Mokrani, Juliette Chommeloux, Marc Pineton de Chambrun, Guillaume Hékimian, Charles-Edouard Luyt
Antibiotic resistance is a major health problem and will be probably one of the leading causes of deaths in the coming years. One of the most effective ways to fight against resistance is to decrease antibiotic consumption. Intensive care units (ICUs) are places where antibiotics are widely prescribed, and where multidrug-resistant pathogens are frequently encountered. However, ICU physicians may have opportunities to decrease antibiotics consumption and to apply antimicrobial stewardship programs. The main measures that may be implemented include refraining from immediate prescription of antibiotics when infection is suspected (except in patients with shock, where immediate administration of antibiotics is essential); limiting empiric broad-spectrum antibiotics (including anti-MRSA antibiotics) in patients without risk factors for multidrug-resistant pathogens; switching to monotherapy instead of combination therapy and narrowing spectrum when culture and susceptibility tests results are available; limiting the use of carbapenems to extended-spectrum beta-lactamase-producing Enterobacteriaceae, and new beta-lactams to difficult-to-treat pathogen (when these news beta-lactams are the only available option); and shortening the duration of antimicrobial treatment, the use of procalcitonin being one tool to attain this goal...
May 6, 2023: Annals of Intensive Care
#20
JOURNAL ARTICLE
Matteo Boattini, Gabriele Bianco, Davide Ghibaudo, Sara Comini, Silvia Corcione, Rossana Cavallo, Francesco Giuseppe De Rosa, Cristina Costa
Rapid detection of extended-spectrum-β-lactamase (ESBL) is of paramount importance to accelerate clinical decision-making, optimize antibiotic treatment, and implement adequate infection control measures. This study was aimed at assessing the impact of direct detection of CTX-M ESBL-producers on antimicrobial management of Escherichia coli bloodstream infections over a 2-year period. This study included all E. coli bloodstream infection (BSI) events that were serially processed through a rapid workflow with communication to the clinicians of direct detection of CTX-M ESBL-producers and conventional culture-based workflow...
February 27, 2023: Antibiotics
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
