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https://www.readbyqxmd.com/read/28453799/early-to-mid-term-results-after-total-cavopulmonary-connection-performed-in-the-second-decade-of-life
#1
Alexandre Metras, Virginie Fouilloux, Mohammed Al-Yamani, Xavier Roques, Loic Macé, Jean-Benoît Thambo, Dominique Metras, Bernard Kreitmann, François Roubertie
OBJECTIVES: Total cavopulmonary connection (TCPC) performed in the second decade of life has rarely been studied. Thus, we investigated (bicentric study) early and late morbidity and mortality following completion of TCPC in these patients. METHODS: From January 1999 to June 2014, 63 patients (14.5 ± 2.9 years) underwent TCPC (extracardiac conduit). Palliation before completion was an isolated bidirectional cavopulmonary shunt (BCPS) in 3 patients or BCPS associated with additional pulmonary blood flow (APBF) that was either antegrade (Group 1) in 38 (63%) or retrograde (Group 2) in 22 (37%)...
May 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28453663/rasmussen-torvik-et-al-respond-to-the-perfect-measure-of-diastolic-dysfunction
#2
Laura J Rasmussen-Torvik, Laura A Colangelo, Joao A C Lima, David R Jacobs, Carlos J Rodriguez, Samuel S Gidding, Donald M Lloyd-Jones, Sanjiv J Shah
No abstract text is available yet for this article.
April 27, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28453616/prevalence-and-predictors-of-diastolic-dysfunction-according-to-different-classification-criteria-the-coronary-artery-risk-development-in-young-in-adults-study
#3
Laura J Rasmussen-Torvik, Laura A Colangelo, Joao A C Lima, David R Jacobs, Carlos J Rodriguez, Samuel S Gidding, Donald M Lloyd-Jones, Sanjiv J Shah
Heart failure with preserved ejection fraction is often preceded by diastolic dysfunction (DD). Of several published DD criteria, it is unclear which, if any, are applicable to data obtained in epidemiologic cohorts. We evaluated the prevalence of DD using previously published definitions in a population-based study, the Coronary Artery Risk Development in Young Adults (CARDIA) Study, using data gathered in 2010-2011. Echocardiography was performed on 3,474 individuals (mean age = 50.2 years) at the CARDIA year 25 examination...
April 27, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28453609/invited-commentary-searching-for-the-perfect-measure-of-diastolic-dysfunction-a-futile-exercise
#4
Ambarish Pandey, Jarett D Berry
Heart failure with preserved ejection fraction (HFpEF) is common, recalcitrant to treatment, and associated with poor outcomes. Diastolic dysfunction (DD) is an independent predictor of HFpEF risk, associated clinical manifestations, and long-term outcomes. However, the usefulness of diastolic function assessment is limited by the heterogeneity in the existing definitions of DD. In this issue of the Journal, Rasmussen-Torvik et al. (Am J Epidemiol. 2017;000(00):000-000) have highlighted this problem by evaluating the prevalence and concordance of 4 established definitions of DD in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort...
April 27, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28453545/the-impact-of-gender-difference-on-clinical-and-echocardiographic-outcomes-in-patients-with-heart-failure-after-cardiac-resynchronization-therapy-a-systematic-review-and-meta-analysis
#5
Fa-Hui Yin, Chun-Lei Fan, Ya-Ya Guo, Hai Zhu, Zhi-Lu Wang
BACKGROUND: Cardiac resynchronization therapy(CRT) has been recommended as a standard treatment for patients with advanced heart failure. However, some studies have reported different clinical and echocardiographic outcomes between male and female patients who received CRT. This Meta-analysis is to determine whether gender difference has any significant impact on clinical and echocardiographic outcomes in patients with heart failure after CRT. METHODS AND RESULTS: PubMed, Embase, and the Cochrane library database were searched...
2017: PloS One
https://www.readbyqxmd.com/read/28453363/a-polyphenol-based-multicomponent-nutraceutical-in-dysmetabolism-and-oxidative-stress-results-from-a-pilot-study
#6
Roberto Corsi, Giovanni Mosti, Attilio Cavezzi, Simone Ugo Urso, Gayla Dimitrova, Elena Fioroni, Roberto Colucci, Valentina Quinzi
To assess short-term efficacy and safety of a multicomponent nutraceutical (MCN) on dysmetabolism and oxidative stress, a pilot prospective observational study was performed on 21 individuals (12 men and 9 women) who took, for 60 days, 2 tablets per day of an MCN based on antioxidants and metabolism regulators: hydroxytyrosol (15 mg), maqui (300 mg), amla (200 mg), monacolin K (10 mg), berberine (245 mg), astaxanthin (0.5 mg), coenzyme Q10 (100 mg), and folic acid (200 mcg). On day 0 (T0) and day 60 (T60), all participants underwent laboratory tests related to lipid profile, carbohydrate metabolism, oxidative stress, and cellular inflammation...
April 28, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28449023/racial-disparities-in-blood-pressure-trajectories-of-preterm-children-the-role-of-family-and-neighborhood-socioeconomic-status
#7
Thomas E Fuller-Rowell, David S Curtis, Pamela K Klebanov, Jeanne Brooks-Gunn, Gary W Evans
Racial disparities in cardiovascular disease mortality in the United States remain substantial. However, the childhood roots of these disparities are not well understood. In the current study, we examined racial differences in blood pressure trajectories across early childhood in a sample of African-American and European-American low-birth-weight preterm infants. Family and neighborhood socioeconomic status (SES), measured at baseline, were also examined as explanations for subsequent group disparities. Analyses focused on 407 African-American and 264 European-American children who participated in the Infant Health and Development Program, a US longitudinal study of preterm children born in 1985...
April 25, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28448842/risk-of-incident-myocardial-infarction-by-gender-interactions-with-serum-lipids-blood-pressure-and-smoking-the-troms%C3%A3-study-1979-2012
#8
Grethe Albrektsen, Ivar Heuch, Maja-Lisa Løchen, Dag Steinar Thelle, Tom Wilsgaard, Inger Njølstad, Kaare Harald Bønaa
BACKGROUND AND AIMS: Overall, men have roughly twice the risk of myocardial infarction (MI) compared to women, but what causes this contrast is unclear. Identification of subgroups where the gender contrast in risk is particularly low or high, may provide new insight. In the search for such subgroups, we focus on gender-specific effects of established coronary heart disease (CHD) risk factors. Heterogeneity across age groups is also explored. METHODS: Population-based prospective study from Tromsø, Norway, comprising 33,859 individuals (51% women); 2746 individuals (854 women) received a diagnosis of MI during follow-up at ages 35-94 years...
April 9, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28448779/effect-of-a-pharmacist-led-program-on-improving-outcomes-in-patients-with-type-2-diabetes-mellitus-from-northern-cyprus-a-randomized-controlled-trial
#9
Eylem Ilktac Korcegez, Mesut Sancar, Kutay Demirkan
BACKGROUND: The management of type 2 diabetes mellitus is complex, requiring continuous medical care by health care professionals and considerable self-care efforts by patients. Pharmacist-led care programs have been shown to help patients with diabetes succeed in achieving treatment goals and improving outcomes. Pharmacist-led care is a new health care concept in Northern Cyprus. OBJECTIVE: To evaluate the effect of a pharmacist-led care program on glycemic control, determined by hemoglobin A1c (A1c), and secondarily on blood pressure, lipid profile, body mass index (BMI), waist circumference, medication adherence, and self-care activities, for patients with type 2 diabetes over a 12-month period...
May 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28448528/minimally-invasive-estimation-of-ventricular-dead-space-volume-through-use-of-frank-starling-curves
#10
Shaun Davidson, Chris Pretty, Antoine Pironet, Thomas Desaive, Nathalie Janssen, Bernard Lambermont, Philippe Morimont, J Geoffrey Chase
This paper develops a means of more easily and less invasively estimating ventricular dead space volume (Vd), an important, but difficult to measure physiological parameter. Vd represents a subject and condition dependent portion of measured ventricular volume that is not actively participating in ventricular function. It is employed in models based on the time varying elastance concept, which see widespread use in haemodynamic studies, and may have direct diagnostic use. The proposed method involves linear extrapolation of a Frank-Starling curve (stroke volume vs end-diastolic volume) and its end-systolic equivalent (stroke volume vs end-systolic volume), developed across normal clinical procedures such as recruitment manoeuvres, to their point of intersection with the y-axis (where stroke volume is 0) to determine Vd...
2017: PloS One
https://www.readbyqxmd.com/read/28448402/left-atrium-measurements-via-computed-tomography-pulmonary-angiogram-as-a-predictor-of-diastolic-dysfunction
#11
Adam N Lick, Raman Danrad, David L Smith, Matthew R Lammi
PURPOSE: Left atrium (LA) enlargement on echocardiography may be an indicator of diastolic dysfunction (DD). It is not well known if computed tomography pulmonary angiography (CTPA) can detect DD. METHODS: A total of 127 patients who underwent both CTPA and echo within 48 hours were analyzed retrospectively. Left atrium diameters from CTPA were correlated with echo and evaluated against degrees of DD. Computed tomography pulmonary angiography pulmonary artery (PA)/aorta ratio was analyzed as a tool to detect pulmonary hypertension...
April 26, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28448191/total-arterial-compliance-estimated-by-a-novel-method-is-better-related-to-left-ventricular-mass-compared-to-aortic-pulse-wave-velocity-the-safar-study
#12
Theodore G Papaioannou, Athanase D Protogerou, Antonis Argyris, Evangelia Aissopou, George Georgiopoulos, Efthimia Nasothimiou, Christos Tountas, Petros P Sfikakis, Nikolaos Stergiopulos, Dimitrios Tousoulis
The investigation of the association between total arterial compliance (CT)-estimated by a novel technique-with left ventricular mass (LVM) and hypertrophy (LVH). Our hypothesis was that CT may be better related to LVM compared to the gold-standard regional aortic stiffness. Within the frame of the ongoing cross-sectional study "SAFAR," 226 subjects with established hypertension or with suspected hypertension underwent blood pressure (BP) assessment, carotid-to-femoral pulse wave velocity (cf-PWV), and echocardiographic measurement of LVM...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28448185/addition-of-spironolactone-in-patients-with-resistant-hypertension-a-meta-analysis-of-randomized-controlled-trials
#13
Liping Liu, Bing Xu, Yunfeng Ju
This study was designed to assess the effect of additional spironolactone on blood pressure in patients with resistant hypertension. MEDLINE, EMBASE, and Cochrane Library were searched to identify randomized controlled trials (RCTs) that determined the effect of add-on spironolactone on blood pressure in patients with resistant hypertension compared with a control group. A total of five RCTs met the inclusion criteria. Spironolactone reduced office systolic blood pressure (SBP) by 15.73 mmHg (95% CI -20.45 to -11...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28448179/comparison-of-arterial-stiffness-in-preeclamptic-and-normotensive-pregnant-women-from-a-semi-rural-region-of-south-africa
#14
A Namugowa, J Iputo, J Wandabwa, A Meeme, G A B Buga
BACKGROUND: Preeclampsia is associated with arterial stiffness and endothelial dysfunction. The pathophysiology of arterial tone in preeclampsia has not been well described in rural African population, where the incidence is higher. OBJECTIVE: The aim of the study was to compare arterial tone of preeclamptic with pregnant normotensive women assessed with noninvasive techniques, using applanation tonometry with SphygmoCor. METHOD: This was a cross-sectional study...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28447625/randomised-double-blind-placebo-controlled-assessment-of-the-efficacy-and-safety-of-dietary-supplements-in-prehypertension
#15
F Pelliccia, V Pasceri, G Marazzi, A Arrivi, L Cacciotti, G Pannarale, G Speciale, C Greco, C Gaudio
We aimed to evaluate efficacy and tolerability of a protocol including lifestyle modifications and a novel combination of dietary supplements in prehypertension. A prospective, double-blind, randomised, placebo-controlled trial was conducted in 176 subjects (103 men, aged 52±10 years), with blood pressure (BP) of 130-139 mm Hg systolic and/or 85-89 mm Hg diastolic entered. After a single-blind run-in period, participants were randomised to twice daily placebo (n=88) or a commercially available combination pill (n=88)...
April 27, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28446807/increased-blood-pressure-in-nesfatin-nuclebindin-2-transgenic-mice
#16
Yusaku Mori, Hiroyuki Shimizu, Hideki Kushima, Munenori Hiromura, Michishige Terasaki, Michitaka Tanaka, Aya Osaki, Tsutomu Hirano
Nesfatin/nucleobindin-2 (nesf/NUCB2), a precursor of the anorexigenic protein nesfatin-1, is selectively expressed in the hypothalamic nuclei, which are central to the regulation of the autonomic nervous system. The present study sought to investigate the involvement of nesf/NUCB2 in the regulation of blood pressure and ingestive behavior, by using nesf/NUCB2-transgenic (Tg) mice. Blood pressure and heart rates were measured under conscious and unconscious conditions. Twenty-four-hour water intake and urine volume of male nesf/NUCB2-Tg mice and their littermates in metabolic cages were measured...
April 27, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28446804/the-effects-of-increasing-calcium-channel-blocker-dose-vs-adding-a-diuretic-to-treatment-regimens-for-patients-with-uncontrolled-hypertension
#17
Shigemasa Tani, Kei Asayama, Koji Oiwa, Shinsuke Harasawa, Katsuaki Okubo, Atsuhiko Takahashi, Ayumi Tanabe, Takayoshi Ohkubo, Atsushi Hirayama, Toshio Kushiro
In patients with insufficient blood pressure (BP) control, despite using a combination regimen containing an angiotensin receptor blocker and a calcium channel blocker (CCB), whether a greater dose of CCB or adding a diuretic is more effective at lowering BP remains unclear. We conducted a multicenter randomized clinical trial to compare the efficacy of switching from the daily administration of a single-pill fixed-dose combination of irbesartan (100 mg) and amlodipine (5 mg) to irbesartan (100 mg) with an increased dose of amlodipine (10 mg) (HD group, n=62) or irbesartan (100 mg) and amlodipine (5 mg) with 1 mg of indapamide (D group, n=63) in patients with poorly controlled hypertension...
April 27, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28446647/relationship-between-carotid-arterial-properties-and-cerebral-white-matter-hyperintensities
#18
Tatjana Rundek, David Della-Morte, Hannah Gardener, Chuanhui Dong, Matthew S Markert, Jose Gutierrez, Eugene Roberts, Mitchell S V Elkind, Charles DeCarli, Ralph L Sacco, Clinton B Wright
OBJECTIVE: Since arterial stiffness is a functional measure of arterial compliance and may be an important marker of cerebrovascular disease, we examined the association of carotid artery stiffness with white matter hyperintensity volume (WMHV) in a cross-sectional study of 1,166 stroke-free participants. METHODS: Carotid beta stiffness index (STIFF) was assessed by M-mode ultrasound of the common carotid artery and calculated as the ratio of natural log of the difference between systolic and diastolic blood pressure over STRAIN, a ratio of the difference between carotid systolic and diastolic diameter (DD) divided by DD...
April 26, 2017: Neurology
https://www.readbyqxmd.com/read/28446548/regional-left-ventricular-function-does-not-predict-survival-in-ischaemic-cardiomyopathy-after-cardiac-surgery
#19
David L Prior, Susanna R Stevens, Thomas A Holly, Michal Krejca, Alexandros Paraforos, Gerald M Pohost, Krysti Byrd, Tomasz Kukulski, Robert H Jones, Patrice Desvigne-Nickens, Padmini Varadarajan, Aman Amanullah, Grace Lin, Hussein R Al-Khalidi, Gabriel Aldea, Carlo Santambrogio, Andrzej Bochenek, Daniel S Berman
OBJECTIVES: To define the prognostic contribution of global and regional left ventricular (LV) function measurements in patients with ischaemic cardiomyopathy randomised to coronary artery bypass graft surgery (CABG) with (n=501) or without (n=499) surgical ventricular reconstruction (SVR). METHODS: Novel multivariable methods to analyse global and regional LV systolic function were used to better formulate prediction models for long-term mortality following CABG with or without SVR in the entire cohort of 1000 randomised SVR hypothesis patients...
April 26, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28446526/impact-of-different-dietary-approaches-on-blood-pressure-in-hypertensive-and-prehypertensive-patients-protocol-for-a-systematic-review-and-network-meta-analysis
#20
Lukas Schwingshackl, Anna Chaimani, Georg Hoffmann, Carolina Schwedhelm, Heiner Boeing
INTRODUCTION: Lifestyle modification is one of the cornerstones in the management of hypertension. According to the most recent guidelines by the American Heart Association, all patients with hypertension should adopt the following dietary advices: increased consumption of fresh fruits, vegetables, low-fat dairy products and sodium reduction. The aim of the present study is to assess the efficacy of different dietary approaches on systolic and diastolic blood pressure in patients with hypertension and high normal blood pressure in a systematic review including a pairwise and network meta-analysis of randomised trials...
April 26, 2017: BMJ Open
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