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Curcumin absorption

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https://www.readbyqxmd.com/read/28323388/enhanced-intestinal-absorption-of-curcumin-in-caco-2-cell-monolayer-using-mucoadhesive-nanostructured-lipid-carriers
#1
Sanipon Chanburee, Waree Tiyaboonchai
This study aimed to compare the intestinal permeation of curcumin-loaded polymer coated nanostructured lipid carriers (NLCs) and uncoated NLCs using the Caco-2 cell model. The uncoated NLCs were prepared using a warm microemulsion technique, while polymer-coated NLCs were prepared with the same method but were followed by coating particle surface with polyethylene glycol (PEG) 400 or polyvinyl alcohol (PVA). After lyophilization, all formulations possessed a mean size of <400 nm with a zeta potential of ∼-30 mV and a high entrapment efficacy up to 90%...
March 21, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28316232/in-vitro-reduction-of-arsenic-bioavailability-using-dietary-strategies
#2
M J Clemente, V Devesa, D Velez
The main route of human exposure to inorganic arsenic (As) is through consumption of food and water. Continued exposure to inorganic As [As(III) and As(V)] may cause a variety of diseases, including various types of cancer. Removal of As from these sources is complex, especially for food. One way to decrease As exposure could be by reducing intestinal absorption of it. The aim of this study is to seek dietary strategies (pure compounds, extracts, or supplements) that are capable of reducing the amount of As that is absorbed and reaches the systemic circulation...
March 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28314475/pharmacokinetic-based-study-on-lagged-stimulation-of-curcumae-longae-rhizoma-piper-nigrum-couplet-in-their-main-active-components-metabolism-using-uplc-ms-ms
#3
Zhao Chen, Dongmei Sun, Xiaoli Bi, Xiaohui Zeng, Wenhui Luo, Dake Cai, Qiaohuang Zeng, Aili Xu
BACKGROUND: Curcumae Longae Rhizoma is one of the commonly used traditional Chinese medicines, which has multiple biological activities such as relieving stagnation and stasis, pain alleviation, curing amenorrhea and wounds. However, its main active component-curcumin has poor absorption and very fast metabolism in body. To solve this problem, Piper nigrum was introduced for its ability to strengthen bioavailability of other compounds. PURPOSE: In most cases of TCM couplets, all ingredients were prepared and taken simultaneously, which in our opinion did not take full advantage of their interactions...
April 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28249113/fabrication-of-a-soybean-bowman-birk-inhibitor-bbi-nanodelivery-carrier-to-improve-bioavailability-of-curcumin
#4
Chun Liu, Fenfen Cheng, Xiaoquan Yang
Curcumin is a poorly water-soluble drug, and its oral bioavailability is very low. Here, a novel self-assembly nanoparticle delivery carrier has been successfully developed by using soybean Bowman-Birk inhibitor (BBI) to improve the solubility, bioaccessibility, and oral absorption of curcumin. BBI is a unique protein, which can be resistant to the pH range and proteolytic enzymes in the gastrointestinal tract (GIT), bioavailable, and not allergenic. The encapsulation efficiencies (EE) and the loading capacities (LC) of curcumin in the curcumin-loaded BBI nanoparticles (Cur-BBI-NPs, size = 90...
March 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28204880/analysis-of-different-innovative-formulations-of-curcumin-for-improved-relative-oral-bioavailability-in-human-subjects
#5
Martin Purpura, Ryan P Lowery, Jacob M Wilson, Haider Mannan, Gerald Münch, Valentina Razmovski-Naumovski
PURPOSE: The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorption. In this study, we investigated the bioavailability of a new γ-cyclodextrin curcumin formulation (CW8). This formulation was compared to a standardized unformulated curcumin extract (StdC) and two commercially available formulations with purported increased bioavailability: a curcumin phytosome formulation (CSL) and a formulation of curcumin with essential oils of turmeric extracted from the rhizome (CEO)...
February 16, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28178749/improving-on-nature-the-role-of-nanomedicine-in-the-development-of-clinical-natural-drugs
#6
Anna Rita Bilia, Vieri Piazzini, Clizia Guccione, Laura Risaliti, Martina Asprea, Giada Capecchi, Maria Camilla Bergonzi
Natural products have been used as a major source of drugs for millennia, and about half of the pharmaceuticals in use today are derived from natural products. However, their efficacy can be limited because of their low hydrophilicity and intrinsic dissolution rate(s), or physical/chemical instability. In addition, they can present scarce absorption, poor pharmacokinetics and bioavailability, scarce biodistribution, first-pass metabolism, trivial penetration and accumulation in the organs of the body, or low targeting efficacy...
March 2017: Planta Medica
https://www.readbyqxmd.com/read/28012169/curcumin-as-a-potential-candidate-for-treating-hyperlipidemia-a-review-of-cellular-and-metabolic-mechanisms
#7
REVIEW
Yunes Panahi, Yasin Ahmadi, Manouchehr Teymouri, Thomas P Johnston, Amirhossein Sahebkar
Curcumin is an herbal polyphenol extensively investigated for antioxidant, anti-inflammatory and hypolipidaemic properties. In the present review, the efficacy of curcumin for improving a plasma lipid profile has been evaluated and compared with statins, a well-known class of medicines for treating hypercholesterolemia and hyperlipidaemia. Curcumin is presumably most effective in reducing triglyceride (TG), while statins are most efficient in lowering low-density lipoproteins-cholesterol (LDL-C). Additionally, various molecular and metabolic mediators of cholesterol and plasma lipid homeostasis are discussed in relation to how they are modulated by curcumin or statins...
December 24, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28000447/hypocholesterolemic-activity-of-curcumin-is-mediated-by-down-regulating-the-expression-of-niemann-pick-c1-like-1-in-hamsters
#8
Dan Feng, Jun Zou, Shanshan Zhang, Xuechun Li, Minqi Lu
We previously demonstrated that curcumin reduces cholesterol absorption in Caco-2 cells through down-regulating Niemann-Pick C1-like 1 (NPC1L1) expression, but the in vivo effect of curcumin on intestinal cholesterol absorption remains unknown. The present study aimed to investigate the effects and mechanisms of curcumin consumption on cholesterol absorption in hamsters. Male hamsters were fed a high-fat diet supplemented with or without curcumin (0.05% w/w) for 12 weeks. Curcumin supplementation significantly decreased serum total cholesterol (TC) (from 6...
January 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27927067/curcumin-suppresses-inflammatory-cytokines-and-heat-shock-protein-70-release-and-improves-metabolic-parameters-during-experimental-sepsis
#9
Letycia Silvano da Silva, Carlos Henrique Rocha Catalão, Tatiana Tocchini Felippotti, Gabriela Ravanelli de Oliveira-Pelegrin, Sérgio Petenusci, Luis Alexandre Pedro de Freitas, Maria José Alves Rocha
CONTEXT: Curcumin has been reported to have anti-inflammatory, antioxidant and hypoglycaemic properties, besides reducing mortality in sepsis. OBJECTIVE: This study evaluates the biological activities of a curcumin dispersion formulated by spray-drying in experimental sepsis. MATERIALS AND METHODS: Male Wistar rats were subjected to sepsis by caecal ligation and puncture (CLP), controls were sham operated. The animals were treated with curcumin dispersion (100 mg/kg, p...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27902937/study-on-the-interaction-between-curcumin-and-copc-by-spectroscopic-and-docking-methods
#10
Zhen Song, Wen Yuan, Ruitao Zhu, Song Wang, Caifeng Zhang, Binsheng Yang
Curcumin is a widely studied polyphenolic compound which has a variety of biological activity as anti-inflammatory and antitumor drugs. Recent research reported that copper chaperone binding with small molecular may relate to the treatment of cancer. In this work, the interaction between curcumin and CopC has been investigated in detail by means of UV-vis absorption, FTIR, CD, fluorescence spectroscopic and molecular docking methods The results showed that the CopC conformation was altered by curcumin with reduction of β-sheet and increase of random coil...
November 27, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27900602/transepithelial-transport-of-curcumin-in-caco-2-cells-is-significantly-enhanced-by-micellar-solubilisation
#11
Jan Frank, Christina Schiborr, Alexa Kocher, Jürgen Meins, Dariush Behnam, Manfred Schubert-Zsilavecz, Mona Abdel-Tawab
Curcumin, the active constituent of Curcuma longa L. (family Zingiberaceae), has gained increasing interest because of its anti-cancer, anti-inflammatory, anti-diabetic, and anti-rheumatic properties associated with good tolerability and safety up to very high doses of 12 g. Nanoscaled micellar formulations on the base of Tween 80 represent a promising strategy to overcome its low oral bioavailability. We therefore aimed to investigate the uptake and transepithelial transport of native curcumin (CUR) vs. a nanoscaled micellar formulation (Sol-CUR) in a Caco-2 cell model...
March 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/27866299/localization-and-dynamics-of-the-anticarcinogenic-curcumin-with-gm1-and-other-miceller-assemblies
#12
Malay Patra, Manoj Mandal, Abhijit Chakrabarti, Chaitali Mukhopadhyay
Structural transitions involving shape changes play an important role in cellular physiology and enhance the bioavailability of the natural food like curcumin in surfactant aggregates. In this work, we have studied the localization, dynamics and stability of curcumin in various miceller assemblies using a combination of absorbance and fluorescence spectroscopic approaches. The measurements of absorption and fluorescence spectra of curcumin revealed that the nature of interactions of ionic and nonionic surfactants and the glycosphingolipid, GM1 with curcumin is significantly different with surfactant concentrations...
November 19, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27813185/new-orally-active-dna-minor-groove-binding-small-molecule-ct-1-acts-against-breast-cancer-by-targeting-tumor-dna-damage-leading-to-p53-dependent-apoptosis
#13
Karan Singh Saini, Hamidullah, Raghib Ashraf, Dhanaraju Mandalapu, Sharmistha Das, Mohd Quadir Siddiqui, Sonam Dwivedi, Jayanta Sarkar, Vishnu Lal Sharma, Rituraj Konwar
Targeting tumor DNA damage and p53 pathway is a clinically established strategy in the development of cancer chemotherapeutics. Majority of anti-cancer drugs are delivered through parenteral route for reasons like severe toxicity, lack of stability, and poor enteral absorption. Current DNA targeting drugs in clinical like anthracycline suffers from major drawbacks like cardiotoxicity. Here, we report identification of a new orally active small molecule curcumin-triazole conjugate (CT-1) with significant anti-breast cancer activity in vitro and in vivo...
April 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/27725194/tacrolimus-and-curcumin-co-loaded-liposphere-gel-synergistic-combination-towards-management-of-psoriasis
#14
Anjali Jain, Sindhu Doppalapudi, Abraham J Domb, Wahid Khan
Psoriasis is an autoimmune skin disorder characterized by hyper proliferation and poor differentiation of keratinocytes. It significantly affects patient's quality of life. This study reports the anti-psoriatic efficacy of tacrolimus and curcumin loaded liposphere gel formulation. Poor solubility, poor skin penetration and erratic absorption are some problems associated with the topical delivery of these drugs. To overcome these problems, lipospheres containing combination of tacrolimus and curcumin was prepared with a particle size of nearly 50nm and incorporated into a gel for topical application...
December 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27711741/excited-state-dynamics-of-the-medicinal-pigment-curcumin-in-a-hydrogel
#15
Takaaki Harada, Stephen F Lincoln, Tak W Kee
Curcumin is a yellow polyphenol with multiple medicinal effects. These effects, however, are limited due to its poor aqueous stability and solubility. A hydrogel of 3% octadecyl randomly substituted polyacrylate (PAAC18) has been shown to provide high aqueous stability for curcumin under physiological conditions, offering a route for photodynamic therapy. In this study, the excited-state photophysics of curcumin in the PAAC18 hydrogel is investigated using a combination of femtosecond transient absorption and fluorescence upconversion spectroscopy...
October 12, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27683187/enhancement-of-curcumin-bioavailability-via-the-prodrug-approach-challenges-and-prospects
#16
Pahweenvaj Ratnatilaka Na Bhuket, Asma El-Magboub, Ian S Haworth, Pornchai Rojsitthisak
Curcumin is a natural product with many interesting pharmacological properties. However, these are offset by the particularly poor biopharmaceutical properties. The oral bioavailability of curcumin in humans is very low, mainly due to low solubility, poor stability, and extensive metabolism. This has led to multiple approaches to improve bioavailability, including administration of curcumin with metabolism inhibitors, formulation into nanoparticles, modification of the curcumin structure, and development of curcumin prodrugs...
September 28, 2016: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/27660435/self-assembled-nanoparticles-based-on-amphiphilic-chitosan-derivative-and-arginine-for-oral-curcumin-delivery
#17
Mazhar Ali Raja, Shah Zeenat, Muhammad Arif, Chenguang Liu
Curcumin (Cur) is a striking anticancer agent, but its low aqueous solubility, poor absorption, hasty metabolism, and elimination limit its oral bioavailability and consequently hinder its development as a drug. To redress these limitations, amphiphilic chitosan (CS) conjugate with improved mucoadhesion and solubility over a wider pH range was developed by modification with hydrophobic acrylonitrile (AN) and hydrophilic arginine (Arg); the synthesized conjugate (AN-CS-Arg), which was well characterized by Fourier transform infrared and (1)H nuclear magnetic resonance spectroscopy...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27648633/a-combination-of-complexation-and-self-nanoemulsifying-drug-delivery-system-for-enhancing-oral-bioavailability-and-anticancer-efficacy-of-curcumin
#18
Mahendra Shukla, Swati Jaiswal, Abhisheak Sharma, Pradeep Kumar Srivastava, Abhishek Arya, Anil Kumar Dwivedi, Jawahar Lal
OBJECTIVE: Curcumin, the golden spice from Indian saffron, has shown chemoprotective action against many types of cancer including breast cancer. However, poor oral bioavailability is the major hurdle in its clinical application. In the recent years, self-nanoemulsifying drug delivery system (SNEDDS) has emerged as a promising tool to improve the oral absorption and enhancing the bioavailability of poorly water-soluble drugs. In this context, complexation with lipid carriers like phospholipid has also shown the tremendous potential to improve the solubility and therapeutic efficacy of certain drugs with poor oral bioavailability...
October 6, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27626946/curcumin-encapsulated-into-methoxy-poly-ethylene-glycol-poly-%C3%AE%C2%B5-caprolactone-nanoparticles-increases-cellular-uptake-and-neuroprotective-effect-in-glioma-cells
#19
Gregory Marslin, Bruno Filipe Carmelino Cardoso Sarmento, Gregory Franklin, José Alberto Ribeiro Martins, Carlos Jorge Ribeiro Silva, Andreia Ferreira Castro Gomes, Marisa Passos Sárria, Olga Maria Fernandes Pereira Coutinho, Alberto Carlos Pires Dias
Curcumin is a natural polyphenolic compound isolated from turmeric (Curcuma longa) with well-demonstrated neuroprotective and anticancer activities. Although curcumin is safe even at high doses in humans, it exhibits poor bioavailability, mainly due to poor absorption, fast metabolism, and rapid systemic elimination. To overcome these issues, several approaches, such as nanoparticle-mediated targeted delivery, have been undertaken with different degrees of success. The present study was conducted to compare the neuroprotective effect of curcumin encapsulated in poly(ε-caprolactone) and methoxy poly(ethylene glycol) poly(ε-caprolactone) nanoparticles in U251 glioblastoma cells...
March 2017: Planta Medica
https://www.readbyqxmd.com/read/27616885/highly-absorptive-curcumin-reduces-serum-atherosclerotic-low-density-lipoprotein-levels-in-patients-with-mild-copd
#20
Masafumi Funamoto, Yoichi Sunagawa, Yasufumi Katanasaka, Yusuke Miyazaki, Atsushi Imaizumi, Hideaki Kakeya, Hajime Yamakage, Noriko Satoh-Asahara, Maki Komiyama, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
PURPOSE: COPD is mainly caused by tobacco smoking and is associated with a high frequency of coronary artery disease. There is growing recognition that the inflammation in COPD is not only confined to the lungs but also involves the systemic circulation and can impact nonpulmonary organs, including blood vessels. α1-antitrypsin-low-density lipoprotein (AT-LDL) complex is an oxidatively modified LDL that accelerates atherosclerosis. Curcumin, one of the best-investigated natural products, is a powerful antioxidant...
2016: International Journal of Chronic Obstructive Pulmonary Disease
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