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https://www.readbyqxmd.com/read/28545183/therapeutic-potential-of-novel-nano-based-curcumin-compounds-in-vitro-and-in-vivo
#1
Homa Mollaei, Esmaeil Babaei
Despite recent advances in cancer medication, malignant tumors continue to be the second leading cause of death worldwide. Furthermore, introducing a therapeutic compound with low-side effects as well as low-price for consumers is controversial. Recent efforts have been focusing on traditional medicines as a rich source of herbal agents. Curcumin, the major turmeric phytochemical, has been widely assessed as an anti-cancer compound in vitro and in vivo. However, the use of curcumin in cancer treatment has limitations because of its low solubility, poor tissue absorption, rapid metabolism and rapid systemic elimination...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28540461/quantitative-analysis-of-curcumin-loaded-alginate-nanocarriers-in-hydrogels-using-raman-and-attenuated-total-reflection-infrared-spectroscopy
#2
Lynda Miloudi, Franck Bonnier, Dominique Bertrand, Hugh J Byrne, Xavier Perse, Igor Chourpa, Emilie Munnier
Core-shell nanocarriers are increasingly being adapted in cosmetic and dermatological fields, aiming to provide an increased penetration of the active pharmaceutical or cosmetic ingredients (API and ACI) through the skin. In the final form, the nanocarriers (NC) are usually prepared in hydrogels, conferring desired viscous properties for topical application. Combined with the high chemical complexity of the encapsulating system itself, involving numerous ingredients to form a stable core and quantifying the NC and/or the encapsulated active without labor-intensive and destructive methods remains challenging...
May 25, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28494396/a-comparative-study-of-the-spectral-fluorometric-properties-and-photostability-of-natural-curcumin-iron-and-boron-complexed-curcumin
#3
Fatima Mohammed, Fiza Rashid-Doubell, Seamas Cassidy, Fryad Henari
Curcumin is a yellow phenolic compound with a wide range of reported biological effects. However, two main obstacles hinder the use of curcumin therapeutically, namely its poor bioavailability and photostability. We have synthesized two curcumin complexes, the first a boron curcumin complex (B-Cur2) and the second an iron (Fe-Cur3) complex of curcumin. Both derivatives showed high fluorescence efficiency (quantum yield) and greater photostability in solution. The improved photostability could be attributed to the coordination structures and the removal of β-diketone group from curcumin...
April 21, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28488704/targeting-curcumin-to-specific-tumour-cell-environments-the-influence-of-ancillary-ligands
#4
A Glenister, C K J Chen, E M Tondl, D Paterson, T W Hambley, A K Renfrew
Tumour-activation of prodrugs has the potential to improve the efficacy of anticancer agents while minimising systemic toxicity. Cobalt complexes are of interest in this respect as chaperones to deliver and release anticancer agents in the low oxygen, reducing environment of solid tumours. In addition to being able to release a cytotoxic ligand under the conditions of the tumour microenvironment, it is fundamental that the chaperone complex must also be able to penetrate through multiple cell layers to deliver the cytotoxin to all regions of the tumour...
May 10, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28485571/development-of-an-inner-filter-effects-based-upconversion-nanoparticles-curcumin-nanosystem-for-the-sensitive-sensing-of-fluoride-ion
#5
Yan Liu, Qin Ouyang, Huanhuan Li, Zhengzhu Zhang, Quansheng Chen
This paper developed a novel ratiometric fluorescence based sensor for the detection of fluoride ion. Yb(3+), Er(3+) and Tm(3+) co-doped NaYF4 upconversion nanoparticles (UCNPs), which can emit fluorescence at 546 nm, 657 nm, 758 nm and 812 nm under the 980 nm single wavelength excitation, was synthesized, amino-modified and applied as the fluorescent signal indicator. The natural chemical curcumin was served as specific recognition element and mixed with UCNPs to make a nanosystem. In this nanosystem, the absorption peak of curcumin shows bathochromic shift when F(-) was added, causing a upconversion fluorescence quenching at 546 nm and 657 nm through inner filter effects (IFE), while the upconversion emission at 758 nm and 812 nm were essentially unchanged...
May 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28482540/dual-layered-3d-nanofibrous-matrix-incorporated-with-dual-drugs-and-their-synergetic-effect-on-accelerating-wound-healing-through-growth-factor-regulation
#6
Sivakumar Singaravelu, Giriprasath Ramanathan, Uma Tiruchirapalli Sivagnanam
The by-product of the slaughter house was utilized for the development of promising regenerative wound dressing material. Currently, dual-layered nanofibrous spongy scaffold was fabricated for tissue engineering applications. Herein, Keratin (K)-Fibrin (F)-Gelatin (G) 3D sponge loaded with Mupirocin (M) was fabricated with the naturally derived materials from bovine origin using freeze drying method. Moreover, poly(3-hydroxybutyric acid) (P) and Gelatin(G) solution loaded with Curcumin (C) were electrospun to get the dual drug loaded dual-layered nanofibrous spongy 3D scaffold (KFG:M-PG:C)...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28448635/excited-state-dynamics-of-bis-dehydroxycurcumin-tert-butyl-ester-a-diketo-shifted-derivative-of-the-photosensitizer-curcumin
#7
Luca Nardo, Angelo Maspero, Andrea Penoni, Giovanni Palmisano, Erika Ferrari, Monica Saladini
Bis-dehydroxycurcumin tert-butyl ester (K2T23) is a derivative of the natural spice curcumin. Curcumin is widely studied for its multiple therapeutic properties, including photosensitized cytotoxicity. However, the full exploitation of curcumin phototoxic potential is hindered by the extreme instability of its excited state, caused by very efficient non radiative decay by means of transfer of the enolic proton to the nearby keto oxygen. K2T23 is designed to exhibit a tautomeric equilibrium shifted toward the diketo conformers with respect to natural curcumin...
2017: PloS One
https://www.readbyqxmd.com/read/28431975/liposomal-curcumin-alters-chemosensitivity-of-breast-cancer-cells-to-adriamycin-via-regulating-microrna-expression
#8
Siying Zhou, Jian Li, Hanzi Xu, Sijie Zhang, Xiu Chen, Wei Chen, Sujin Yang, Shanliang Zhong, Jianhua Zhao, Jinhai Tang
BACKGROUND: Emerging evidence suggests that curcumin can overcome drug resistance to classical chemotherapies, but poor bioavailability and low absorption have limited its clinical use and the mechanisms remain unclear. Also, Adriamycin (Adr) is one of the most active cytotoxic agents in breast cancer; however, the high resistant rate of Adr leads to a poor prognosis. METHODS: We utilized encapsulation in liposomes as a strategy to improve the bioavailability of curcumin and demonstrated that liposomal curcumin altered chemosensitivity of Adr-resistant MCF-7 human breast cancer (MCF-7/Adr) by MTT assay...
April 18, 2017: Gene
https://www.readbyqxmd.com/read/28427235/catan-ionic-hybrid-lipidic-nano-carriers-for-enhanced-bioavailability-and-anti-tumor-efficacy-of-chemodrugs
#9
Bilin Liu, Dan He, Jianyong Wu, Quan Sun, Mi Zhang, Qunyou Tan, Yao Li, Jingqing Zhang
To date there has not been any report on catan-ionic hybrid lipidic nano-carriers, let alone a report on applying them to deliver insoluble anti-tumor drugs. Catan-ionic hybrid lipidic nano-carriers containing curcumin (CUR-C-HLN) inherit the merits of catan-ionic systems, hybrid lipidic systems and nano-structured carriers (the second-generation substitute of solid lipidic nano-systems). Catan-ionic surfactants increased microvesicle stabilization by producing unordered isometric clusters, enhanced absorptive amount as an inhibitor of enzyme and protein, improved tumor accumulation by cellular endocytosis and membranous fusion; hybrid lipids helped to obtain high drug content and low leakage by forming a less-organized matrix arrangement...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28419458/therapeutic-potential-of-novel-formulated-forms-of-curcumin-in-the-treatment-of-breast-cancer-by-the-targeting-of-cellular-and-physiological-dysregulated-pathways
#10
REVIEW
Amir Tajbakhsh, Malihe Hasanzadeh, Mehdi Rezaee, Mostafa Khedri, Majid Khazaei, Soodabeh ShahidSales, Gordon A Ferns, Seyed Mahdi Hassanian, Amir Avan
Breast cancer is among the most important causes of cancer related death in women. There is a need for novel agents for targeting key signaling pathways to either improve the efficacy of the current therapy, or reduce toxicity. There is some evidence that curcumin may have antitumor activity in breast cancer. Several clinical trials have investigated its activity in patients with breast cancer, including a recent trial in breast cancer patients receiving radiotherapy, in whom it was shown that curcumin reduced the severity of radiation dermatitis, although it is associated with low bioavailability...
April 17, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28394128/water-soluble-pd8l4-self-assembled-molecular-barrel-as-an-aqueous-carrier-for-hydrophobic-curcumin
#11
Imtiyaz Ahmad Bhat, Ruchi Jain, Mujahuddin M Siddiqui, Deepak K Saini, Partha Sarathi Mukherjee
A tetrafacial water-soluble molecular barrel (1) was synthesized by coordination driven self-assembly of a symmetrical tetrapyridyl donor (L) with a cis-blocked 90° acceptor [cis-(en)Pd(NO3)2] (en = ethane-1,2-diamine). The open barrel structure of (1) was confirmed by single crystal X-ray diffraction. The presence of a hydrophobic cavity with large windows makes it an ideal candidate for encapsulation and carrying hydrophobic drug like curcumin in an aqueous medium. The barrel (1) encapsulates curcumin inside its molecular cavity and protects highly photosensitive curcumin from photodegradation...
April 10, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28365185/curcumin-and-its-cyclohexanone-analogue-inhibited-human-equilibrative-nucleoside-transporter-1-ent1-in-pancreatic-cancer-cells
#12
Jezrael L Revalde, Yan Li, Tharaka S Wijeratne, Piyush Bugde, Bill C Hawkins, Rhonda J Rosengren, James W Paxton
Our group investigated combining the phytochemical curcumin and gemcitabine in a liposome, to improve gemcitabine's activity against pancreatic tumours. While optimising the curcumin: gemcitabine ratio for co-encapsulation, we found that increasing curcumin concentrations relative to gemcitabine resulted in antagonistic interactions. As curcumin is a promiscuous transporter inhibitor; we suspected that increased resistance occurred via inhibition of Equilibrative nucleoside transporter 1 (ENT1)-mediated gemcitabine uptake...
May 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28323388/enhanced-intestinal-absorption-of-curcumin-in-caco-2-cell-monolayer-using-mucoadhesive-nanostructured-lipid-carriers
#13
Sanipon Chanburee, Waree Tiyaboonchai
This study aimed to compare the intestinal permeation of curcumin-loaded polymer coated nanostructured lipid carriers (NLCs) and uncoated NLCs using the Caco-2 cell model. The uncoated NLCs were prepared using a warm microemulsion technique, while polymer-coated NLCs were prepared with the same method but were followed by coating particle surface with polyethylene glycol (PEG) 400 or polyvinyl alcohol (PVA). After lyophilization, all formulations possessed a mean size of <400 nm with a zeta potential of ∼-30 mV and a high entrapment efficacy up to 90%...
March 21, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28316232/in-vitro-reduction-of-arsenic-bioavailability-using-dietary-strategies
#14
M J Clemente, V Devesa, D Vélez
The main route of human exposure to inorganic arsenic (As) is through the consumption of food and water. Continued exposure to inorganic As [As(III) and As(V)] may cause a variety of diseases, including various types of cancer. The removal of As from these sources is complex, especially for food. One way to decrease As exposure could be by reducing intestinal absorption of it. The aim of this study is to seek dietary strategies (pure compounds, extracts, or supplements) that are capable of reducing the amount of As that is absorbed and reaches systemic circulation...
May 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28314475/pharmacokinetic-based-study-on-lagged-stimulation-of-curcumae-longae-rhizoma-piper-nigrum-couplet-in-their-main-active-components-metabolism-using-uplc-ms-ms
#15
Zhao Chen, Dongmei Sun, Xiaoli Bi, Xiaohui Zeng, Wenhui Luo, Dake Cai, Qiaohuang Zeng, Aili Xu
BACKGROUND: Curcumae Longae Rhizoma is one of the commonly used traditional Chinese medicines, which has multiple biological activities such as relieving stagnation and stasis, pain alleviation, curing amenorrhea and wounds. However, its main active component-curcumin has poor absorption and very fast metabolism in body. To solve this problem, Piper nigrum was introduced for its ability to strengthen bioavailability of other compounds. PURPOSE: In most cases of TCM couplets, all ingredients were prepared and taken simultaneously, which in our opinion did not take full advantage of their interactions...
April 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28249113/fabrication-of-a-soybean-bowman-birk-inhibitor-bbi-nanodelivery-carrier-to-improve-bioavailability-of-curcumin
#16
Chun Liu, Fenfen Cheng, Xiaoquan Yang
Curcumin is a poorly water-soluble drug, and its oral bioavailability is very low. Here, a novel self-assembly nanoparticle delivery carrier has been successfully developed by using soybean Bowman-Birk inhibitor (BBI) to improve the solubility, bioaccessibility, and oral absorption of curcumin. BBI is a unique protein, which can be resistant to the pH range and proteolytic enzymes in the gastrointestinal tract (GIT), bioavailable, and not allergenic. The encapsulation efficiencies (EE) and the loading capacities (LC) of curcumin in the curcumin-loaded BBI nanoparticles (Cur-BBI-NPs, size = 90...
March 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28204880/analysis-of-different-innovative-formulations-of-curcumin-for-improved-relative-oral-bioavailability-in-human-subjects
#17
Martin Purpura, Ryan P Lowery, Jacob M Wilson, Haider Mannan, Gerald Münch, Valentina Razmovski-Naumovski
PURPOSE: The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorption. In this study, we investigated the bioavailability of a new γ-cyclodextrin curcumin formulation (CW8). This formulation was compared to a standardized unformulated curcumin extract (StdC) and two commercially available formulations with purported increased bioavailability: a curcumin phytosome formulation (CSL) and a formulation of curcumin with essential oils of turmeric extracted from the rhizome (CEO)...
February 16, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28178749/improving-on-nature-the-role-of-nanomedicine-in-the-development-of-clinical-natural-drugs
#18
REVIEW
Anna Rita Bilia, Vieri Piazzini, Clizia Guccione, Laura Risaliti, Martina Asprea, Giada Capecchi, Maria Camilla Bergonzi
Natural products have been used as a major source of drugs for millennia, and about half of the pharmaceuticals in use today are derived from natural products. However, their efficacy can be limited because of their low hydrophilicity and intrinsic dissolution rate(s), or physical/chemical instability. In addition, they can present scarce absorption, poor pharmacokinetics and bioavailability, scarce biodistribution, first-pass metabolism, trivial penetration and accumulation in the organs of the body, or low targeting efficacy...
March 2017: Planta Medica
https://www.readbyqxmd.com/read/28012169/curcumin-as-a-potential-candidate-for-treating-hyperlipidemia-a-review-of-cellular-and-metabolic-mechanisms
#19
REVIEW
Yunes Panahi, Yasin Ahmadi, Manouchehr Teymouri, Thomas P Johnston, Amirhossein Sahebkar
Curcumin is an herbal polyphenol extensively investigated for antioxidant, anti-inflammatory and hypolipidaemic properties. In the present review, the efficacy of curcumin for improving a plasma lipid profile has been evaluated and compared with statins, a well-known class of medicines for treating hypercholesterolemia and hyperlipidaemia. Curcumin is presumably most effective in reducing triglyceride (TG), while statins are most efficient in lowering low-density lipoproteins-cholesterol (LDL-C). Additionally, various molecular and metabolic mediators of cholesterol and plasma lipid homeostasis are discussed in relation to how they are modulated by curcumin or statins...
December 24, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28000447/hypocholesterolemic-activity-of-curcumin-is-mediated-by-down-regulating-the-expression-of-niemann-pick-c1-like-1-in-hamsters
#20
Dan Feng, Jun Zou, Shanshan Zhang, Xuechun Li, Minqi Lu
We previously demonstrated that curcumin reduces cholesterol absorption in Caco-2 cells through down-regulating Niemann-Pick C1-like 1 (NPC1L1) expression, but the in vivo effect of curcumin on intestinal cholesterol absorption remains unknown. The present study aimed to investigate the effects and mechanisms of curcumin consumption on cholesterol absorption in hamsters. Male hamsters were fed a high-fat diet supplemented with or without curcumin (0.05% w/w) for 12 weeks. Curcumin supplementation significantly decreased serum total cholesterol (TC) (from 6...
January 18, 2017: Journal of Agricultural and Food Chemistry
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