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Curcumin absorption

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https://www.readbyqxmd.com/read/29908276/interactions-of-quercetin-curcumin-epigallocatechin-gallate-and-folic-acid-with-gelatin
#1
Tingting Yang, Huiru Yang, Yan Fan, Bafang Li, Hu Hou
Some small bioactive molecules from food show the potential health benefits, but with poor chemical stability and bioavailability. The interactions between small molecules and gelatin were investigated. Fluorescence experiments demonstrated that the bimolecular quenching constants (kq ) of complexes (gelatin-quercetin, gelatin-curcumin, gelatin-epigallocatechin gallate, gelatin-folic acid) were 3.7 × 1012  L·mol-1 ·s-1 , 1.4 × 1012  L·mol-1 ·s-1 , 2.7 × 1012  L·mol-1 ·s-1 and 8.5 × 1012  L·mol-1 ·s-1 , indicating that fluorescence quenching did not arise from a dynamical mechanism, but from gelatin-small molecules binding...
June 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29868656/characterization-of-a-nir-absorbing-thienyl-curcumin-contrast-agent-for-photoacoustic-imaging
#2
Stephanie Bellinger, Maryam Hatamimoslehabadi, Raymond E Borg, Jeffrey La, Peter Catsoulis, Farha Mithila, Chandra Yelleswarapu, Jonathan Rochford
The synthesis and characterization of a bis(2-dimethylaminothien-5-yl)curcumin boron difluoride chromophore is presented. Photophysical, electrochemical and computational investigations establish the properties of its absorption in the Vis-NIR spectral range relative to established curcumin dyes. Application of this thienyl curcumin dye as a photoacoustic contrast agent is investigated against the dicarbocyanine Cy5 dye in the 675-735 nm excitation range.
June 5, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29737515/phytosomal-curcumin-inhibits-tumor-growth-in-colitis-associated-colorectal-cancer
#3
Reyhaneh Moradi Marjaneh, Farzad Rahmani, Seyed Mahdi Hassanian, Nastaran Rezaei, Milad Hashemzehi, Afsane Bahrami, Fatemeh Ariakia, Hamid Fiuji, Amirhosein Sahebkar, Amir Avan, Majid Khazaei
Colorectal-cancer (CRC) is the third leading cause of death due to cancer, supporting the need for identification of novel anticancer drug to improve the efficacy of current-therapy. There is growing bodies of data showing the antitumor-activity of curcumin, although it is associated with low absorption. The aim of current study was explored the therapeutic-potential of novel phytosomal curcumin as well as its application in combination with 5-Flurouracil (5-FU) in a mouse-model of colitis-associated colon-cancer...
May 8, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29735054/pluronics-modified-liposomes-for-curcumin-encapsulation-sustained-release-stability-and-bioaccessibility
#4
Zi-Ling Li, Sheng-Feng Peng, Xing Chen, Yu-Qing Zhu, Li-Qiang Zou, Wei Liu, Cheng-Mei Liu
The present work evaluated the feasibility of different pluronics (F127, F87 and P85) utilized as modifiers to improve the stability and bioaccessibility of curcumin liposomes (cur-Lps). Pluronics modified curcumin liposomes (cur-pluronic-Lps) were prepared by thin film evaporation combined with dynamic high pressure microfluidization. The particle size and polydispersity index of cur-pluronic-Lps was significantly lower than cur-Lps. Fourier transform infrared spectroscopy analysis revealed that curcumin was loaded in liposomes successfully and X-ray diffraction suggested that curcumin in the liposomes was in an amorphous state...
June 2018: Food Research International
https://www.readbyqxmd.com/read/29734652/antimalarial-activity-of-orally-administered-curcumin-incorporated-in-eudragit-%C3%A2-containing-liposomes
#5
Elisabet Martí Coma-Cros, Arnau Biosca, Elena Lantero, Maria Letizia Manca, Carla Caddeo, Lucía Gutiérrez, Miriam Ramírez, Livia Neves Borgheti-Cardoso, Maria Manconi, Xavier Fernàndez-Busquets
Curcumin is an antimalarial compound easy to obtain and inexpensive, having shown little toxicity across a diverse population. However, the clinical use of this interesting polyphenol has been hampered by its poor oral absorption, extremely low aqueous solubility and rapid metabolism. In this study, we have used the anionic copolymer Eudragit® S100 to assemble liposomes incorporating curcumin and containing either hyaluronan (Eudragit-hyaluronan liposomes) or the water-soluble dextrin Nutriose® FM06 (Eudragit-nutriosomes)...
May 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29658319/preparation-of-poly-l-lysine-based-nanoparticles-with-ph-sensitive-release-of-curcumin-for-targeted-imaging-and-therapy-of-liver-cancer-in-vitro-and-in-vivo
#6
Dae Hyeok Yang, Hyun Joo Kim, Kyeongsoon Park, Jae Kwang Kim, Heung Jae Chun
Poly-l-lysine (PLL) nanoparticle (NP) system was prepared for the controlled release of curcumin (CUR) by pH stimuli, and its theranostic efficacy on cancer was compared to that of CUR solution in vitro and in vivo. Deoxycholic acid (DOCA), methoxy polyethylene glycol (MPEG) and cyanine 5.5 (cy5.5) were conjugated to the amine group of PLL through condensation reaction (PLL-DOCA-MPEG-cy5.5), followed by encapsulation of CUR by dialysis method (PLL-DOCA-MPEG-cy5.5/CUR NPs). The composition, morphology and size distribution of PLL-DOCA-MPEG-cy5...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29611487/complexation-of-bioelements-and-toxic-metals-by-polyphenolic-compounds-implications-for-health
#7
Sylwia Borowska, Malgorzata Michalina Brzoska, Michal Tomczyk
Nowadays growing interest in the possibility of prophylactic and therapeutic use of plant products rich in biologically active compounds has been observed. Among them special interest has been focused on polyphenol-rich products. Owing to multidirectional favourable action of polyphenols, products rich in these compounds are recommended as functional food in the case of civilization diseases. Moreover, data from studies in animal models show that polyphenols may be a promising preventive/therapeutic strategy for xenobiotics, including toxic heavy metals...
April 2, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29600580/curcumin-nanoparticles-potentiate-therapeutic-effectiveness-of-acitrein-in-moderate-to-severe-psoriasis-patients-and-control-serum-cholesterol-levels
#8
Anna Rita Bilia, Maria Camilla Bergonzi, Benedetta Isacchi, Emiliano Antiga, Marzia Caproni
OBJECTIVES: In this study, nanoparticles of curcumin were developed and orally administered to moderate-to-severe psoriasis (Psoriasis Area Severity Index values, PASI > 10) patients, in a placebo controlled, double blind, randomised clinical trial to evaluate the effectiveness. METHODS: Diverse binary systems of curcumin and hydrophilic polymers were investigated to optimise solubility and stability in terms of curcumin residual content and size of the crystals...
March 29, 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29578413/erratum-to-improvement-of-intestinal-absorption-of-curcumin-by-cyclodextrins-and-the-mechanisms-underlying-absorption-enhancement-int-j-pharm-2018-535-340-349
#9
Xinpeng Li, Sachiyo Uehara, Kasirawat Sawangrat, Masaki Morishita, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto
No abstract text is available yet for this article.
April 25, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29546309/supplementation-with-resveratrol-and-curcumin-does-not-affect-the-inflammatory-response-to-a-high-fat-meal-in-older-adults-with-abdominal-obesity-a-randomized-placebo-controlled-crossover-trial
#10
Cécile Vors, Charles Couillard, Marie-Eve Paradis, Iris Gigleux, Johanne Marin, Marie-Claude Vohl, Patrick Couture, Benoît Lamarche
Background: High-fat meals induce postprandial inflammation. Resveratrol is a polyphenol known to prevent comorbidities associated with cardiovascular disease and exerts an anti-inflammatory action. There is also an increasing body of evidence supporting the role of curcumin, a polyphenol from the curcuminoid family, as a modulator of proinflammatory processes. Objective: The objectives of this study were to investigate the following: 1) the bioavailability of resveratrol consumed in combination with curcumin after consumption of a high-fat meal; and 2) the acute combined effects of this combination on the postprandial inflammatory response of subjects with abdominal obesity...
March 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29542686/curcumin-and-dietary-polyphenol-research-beyond-drug-discovery
#11
REVIEW
Tian-Ru Jin
Numerous natural products available over the counter are commonly consumed by healthy, sub-healthy or ill people for the treatment and prevention of various chronic diseases. Among them, a few dietary polyphenols, including the curry compound curcumin, have been attracting the most attention from biomedical researchers and drug developers. Unlike many so-called "good drug candidates", curcumin and several other dietary polyphenols do not have a single known therapeutic target or defined receptor. In addition, the bioavailability of these polyphenols is usually very low due to their poor absorption in the gut...
May 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29452153/functionalization-of-nanodiamond-with-vitamin-e-tpgs-to-facilitate-oral-absorption-of-curcumin
#12
Bingchao Cheng, Hao Pan, Dandan Liu, Dongyang Li, Jinyu Li, Shihui Yu, Guoxin Tan, Weisan Pan
The purpose of this work was to develop a d-α-tocopherol polyethylene glycol 1000 succinate (TPGS) decorated nanodiamond (ND) system loading water-insoluble curcumin (ND/CUR/TPGS) to improve the colloidal dispersity and oral bioavailability of the preparation. CUR was physically loaded into ND clusters, then TPGS was coated to the ND/CUR complex forming amorphous nanostructure on the interparticle nanocage of the ND substrate. The formulation of the nanocomplexes was optimized using response surface methodology, and the optimal ND/CUR/TPGS showed small particle size (196...
April 5, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29436996/herbal-products-for-common-auto-inflammatory-disorders-novel-approaches
#13
Shanoo Suroowan, Fawzi Mahomoodally
BACKGROUND: Common auto-inflammatory disorders (CAIDs) constitute a wide array of ailments ranging from acute allergies to chronic conditions. Globally, CAIDs remain one of the leading causes of disability and morbidity. Despite playing a leading therapeutic role, the vast profusion of anti-inflammatory synthetic agents have not been able to fully resolve a panoply of CAIDs. Additionally, contemporary synthetic therapy approaches remain bounded by a wide array of limitations essentially being adverse effects and unaffordable costs...
2018: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/29420166/curcumin-mediated-regulation-of-intestinal-barrier-function-the-mechanism-underlying-its-beneficial-effects
#14
Siddhartha S Ghosh, Hongliang He, Jing Wang, Todd W Gehr, Shobha Ghosh
Curcumin has anti-inflammatory, anti-oxidant and anti-proliferative properties established largely by in vitro studies. Accordingly, oral administration of curcumin beneficially modulates many diseases including diabetes, fatty-liver disease, atherosclerosis, arthritis, cancer and neurological disorders such as depression, Alzheimer's or Parkinson's disease. However, limited bioavailability and inability to detect curcumin in circulation or target tissues has hindered the validation of a causal role. We established curcumin-mediated decrease in the release of gut bacteria-derived lipopolysaccharide (LPS) into circulation by maintaining the integrity of the intestinal barrier function as the mechanism underlying the attenuation of metabolic diseases (diabetes, atherosclerosis, kidney disease) by curcumin supplementation precluding the need for curcumin absorption...
January 2, 2018: Tissue Barriers
https://www.readbyqxmd.com/read/29360270/in-situ-probing-intracellular-drug-release-from-redox-responsive-micelles-by-united-fret-and-aie
#15
Xuelin Wang, Juanjuan Li, Qi Yan, Yanrui Chen, Aiping Fan, Zheng Wang, Yanjun Zhao
Redox-responsive micelles are versatile nanoplatforms for on-demand drug delivery, but the in situ evaluation of drug release is challenging. Fluorescence resonance energy transfer (FRET) technique shows potential for addressing this, while the aggregation-caused quenching effect limits the assay sensitivity. The aim of the current work is to combine aggregation-induced emission (AIE) probe with FRET to realize drug release assessment from micelles. Tetraphenylethene (TPE) is selected as AIE dye and curcumin (Cur) is chosen as the model drug as well as FRET receptor...
March 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29358184/curcumin-as-an-in-vivo-selective-intestinal-breast-cancer-resistance-protein-inhibitor-in-cynomolgus-monkeys
#16
Tsuyoshi Karibe, Tomoki Imaoka, Koji Abe, Osamu Ando
To estimate the clinical impact of pharmacokinetic modulation via breast cancer resistance protein (BCRP), in vivo approaches in nonclinical settings are desired in drug development. Clinical observation has identified curcumin as a promising candidate for in vivo selective BCRP inhibition, in addition to several well known inhibitors, such as lapatinib and pantoprazole. This study aimed to confirm the inhibitory efficacy of curcumin on gastrointestinal BCRP function in cynomolgus monkeys and to perform comparisons with lapatinib and pantoprazole...
May 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29348099/spray-dried-curcumin-nanoemulsion-a-new-road-to-improvement-of-oral-bioavailability-of-curcumin
#17
Liandong Hu, Qiaofeng Hu, Chenchen Yang
In this study a new soluble solid curcumin nanoemulsion powder was prepared using spray-drying technology to improve the solubility and bioavailability of curcumin. The liquid nanoemulsion consisted of curcumin, Capryol 90, Transcutol P, and Cremophor RH40. The solid nanoemulsion was prepared by spray-drying the liquid nanoemulsion in laboratory spray dryer, using lactose as solid carrier. The in vitro release from powder formulation was 97.6% within 15 min while the release from the curcumin crystalline was about 10%...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29337098/synthesis-and-characterization-of-chitin-curcumin-blended-polyurethane-elastomers
#18
Kashif Mahmood, Khalid Mahmood Zia, Waseem Aftab, Mohammad Zuber, Shazia Tabasum, Aqdas Noreen, Fatima Zia
In this work, chitin-curcumin based polyurethane elastomers (PUEs) were prepared by step growth polymerization technique using hydroxy terminated polybutadiene (HTPB), hexamethylene diisocyanate (HDI), chitin and curcumin. The molecular characterization was done by using FTIR and SS 1 HNMR techniques. The surface morphology and thermal stability was studied by scanning electron microscopy (SEM) and thermal gravimetric analysis (TGA), respectively. Degree of absorption and swelling characters were also determined in water as well as in DMSO...
July 1, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29333037/curcumin-and-natural-derivatives-inhibit-ebola-viral-proteins-an-in-silico-approach
#19
Shruti Baikerikar
Background: Ebola viral disease is a severe and mostly fatal disease in humans caused by Ebola virus. This virus belongs to family Filoviridae and is a single-stranded negative-sense virus. There is no single treatment for this disease which puts forth the need to identify new therapy to control and treat this fatal condition. Curcumin, one of the bioactives of turmeric, has proven antiviral property. Objective: The current study evaluates the inhibitory activity of curcumin, bisdemethoxycurcumin, demethoxycurcumin, and tetrahydrocurcumin against Zaire Ebola viral proteins (VPs)...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29317753/influences-of-mesoporous-magnesium-calcium-silicate-on-mineralization-degradability-cell-responses-curcumin-release-from-macro-mesoporous-scaffolds-of-gliadin-based-biocomposites
#20
Sicheng Wang, Zhengrong Gu, Zhiwei Wang, Xiao Chen, Liehu Cao, Liang Cai, Quan Li, Jie Wei, Jung-Woog Shin, Jiacan Su
Macro-mesoporous scaffolds based on wheat gliadin (WG)/mesoporous magnesium calcium silicate (m-MCS) biocomposites (WMC) were developed for bone tissue regeneration. The increasing amount of m-MCS significantly improved the mesoporosity and water absorption of WMC scaffolds while slightly decreased their compressive strength. With the increase of m-MCS content, the degradability of WMC scaffolds was obviously enhanced, and the decrease of pH value could be slow down after soaking in Tris-HCl solution for different time...
January 9, 2018: Scientific Reports
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