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Curcumin absorption

Anjali Jain, Sindhu Doppalapudi, Abraham J Domb, Wahid Khan
Psoriasis is an autoimmune skin disorder characterized by hyper proliferation and poor differentiation of keratinocytes. It significantly affects patient's quality of life. This study reports the anti-psoriatic efficacy of tacrolimus and curcumin loaded liposphere gel formulation. Poor solubility, poor skin penetration and erratic absorption are some problems associated with the topical delivery of these drugs. To overcome these problems, lipospheres containing combination of tacrolimus and curcumin was prepared with a particle size of nearly 50nm and incorporated into a gel for topical application...
October 8, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
Takaaki Harada, Stephen F Lincoln, Tak W Kee
Curcumin is a yellow polyphenol with multiple medicinal effects. These effects, however, are limited due to its poor aqueous stability and solubility. A hydrogel of 3% octadecyl randomly substituted polyacrylate (PAAC18) has been shown to provide high aqueous stability for curcumin under physiological conditions, offering a route for photodynamic therapy. In this study, the excited-state photophysics of curcumin in the PAAC18 hydrogel is investigated using a combination of femtosecond transient absorption and fluorescence upconversion spectroscopy...
October 12, 2016: Physical Chemistry Chemical Physics: PCCP
Pahweenvaj Ratnatilaka Na Bhuket, Asma El-Magboub, Ian S Haworth, Pornchai Rojsitthisak
Curcumin is a natural product with many interesting pharmacological properties. However, these are offset by the particularly poor biopharmaceutical properties. The oral bioavailability of curcumin in humans is very low, mainly due to low solubility, poor stability, and extensive metabolism. This has led to multiple approaches to improve bioavailability, including administration of curcumin with metabolism inhibitors, formulation into nanoparticles, modification of the curcumin structure, and development of curcumin prodrugs...
September 28, 2016: European Journal of Drug Metabolism and Pharmacokinetics
Mazhar Ali Raja, Shah Zeenat, Muhammad Arif, Chenguang Liu
Curcumin (Cur) is a striking anticancer agent, but its low aqueous solubility, poor absorption, hasty metabolism, and elimination limit its oral bioavailability and consequently hinder its development as a drug. To redress these limitations, amphiphilic chitosan (CS) conjugate with improved mucoadhesion and solubility over a wider pH range was developed by modification with hydrophobic acrylonitrile (AN) and hydrophilic arginine (Arg); the synthesized conjugate (AN-CS-Arg), which was well characterized by Fourier transform infrared and (1)H nuclear magnetic resonance spectroscopy...
2016: International Journal of Nanomedicine
Mahendra Shukla, Swati Jaiswal, Abhisheak Sharma, Pradeep Kumar Srivastava, Abhishek Arya, Anil Kumar Dwivedi, Jawahar Lal
OBJECTIVE: Curcumin, the golden spice from Indian saffron, has shown chemoprotective action against many types of cancer including breast cancer. However, poor oral bioavailability is the major hurdle in its clinical application. In the recent years, self-nanoemulsifying drug delivery system (SNEDDS) has emerged as a promising tool to improve the oral absorption and enhancing the bioavailability of poorly water-soluble drugs. In this context, complexation with lipid carriers like phospholipid has also shown the tremendous potential to improve the solubility and therapeutic efficacy of certain drugs with poor oral bioavailability...
October 6, 2016: Drug Development and Industrial Pharmacy
Gregory Marslin, Bruno Filipe Carmelino Cardoso Sarmento, Gregory Franklin, José Alberto Ribeiro Martins, Carlos Jorge Ribeiro Silva, Andreia Ferreira Castro Gomes, Marisa Passos Sárria, Olga Maria Fernandes Pereira Coutinho, Alberto Carlos Pires Dias
Curcumin is a natural polyphenolic compound isolated from turmeric (Curcuma longa) with well-demonstrated neuroprotective and anticancer activities. Although curcumin is safe even at high doses in humans, it exhibits poor bioavailability, mainly due to poor absorption, fast metabolism, and rapid systemic elimination. To overcome these issues, several approaches, such as nanoparticle-mediated targeted delivery, have been undertaken with different degrees of success. The present study was conducted to compare the neuroprotective effect of curcumin encapsulated in poly(ε-caprolactone) and methoxy poly(ethylene glycol) poly(ε-caprolactone) nanoparticles in U251 glioblastoma cells...
September 14, 2016: Planta Medica
Masafumi Funamoto, Yoichi Sunagawa, Yasufumi Katanasaka, Yusuke Miyazaki, Atsushi Imaizumi, Hideaki Kakeya, Hajime Yamakage, Noriko Satoh-Asahara, Maki Komiyama, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
PURPOSE: COPD is mainly caused by tobacco smoking and is associated with a high frequency of coronary artery disease. There is growing recognition that the inflammation in COPD is not only confined to the lungs but also involves the systemic circulation and can impact nonpulmonary organs, including blood vessels. α1-antitrypsin-low-density lipoprotein (AT-LDL) complex is an oxidatively modified LDL that accelerates atherosclerosis. Curcumin, one of the best-investigated natural products, is a powerful antioxidant...
2016: International Journal of Chronic Obstructive Pulmonary Disease
M E Barbinta-Patrascu, N Badea, C Pirvu, M Bacalum, C Ungureanu, P L Nadejde, C Ion, I Rau
Novel nanohybrids consisting of nano-Ag, chitosan, lipids and phyto-compounds (chlorophyll a and curcumin) have been achieved through a simple bottom-up strategy, resulting in stable (ZP=-30.9mV) and spherical-shaped nano-entities with size <200nm (estimated by AFM analysis and DLS measurements). The formation of these biohybrids was monitored by absorption and emission spectroscopy, exploiting the spectral fingerprint of chlorophyll a. The bio-performances of these hybrid materials such as: high antioxidant activity (96...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Heni Rachmawati, Dewi Safitri, Aditya Trias Pradana, I Ketut Adnyana
Curcumin, a hydrophobic polyphenol compound derived from the rhizome of the Curcuma genus, has a wide spectrum of biological and pharmacological applications. Previously, curcumin nanoparticles with different stabilizers had been produced successfully in order to enhance solubility and per oral absorption. In the present study, we tested the anti-inflammatory effect of d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS)-stabilized curcumin nanoparticles in vivo. Lambda-carrageenan (λ-carrageenan) was used to induce inflammation in rats; it was given by an intraplantar route and intrapelurally through surgery in the pleurisy test...
August 16, 2016: Pharmaceutics
Osman Bilgin Gulcicek, Ali Solmaz, Hakan Yiğitbaş, Candas Ercetin, Erkan Yavuz, Kamil Ozdogan, Sinan Arici, Asli Kahraman Akkalp, Tulin Sarac, Fatih Çelebi, Atilla Celik
Introduction. Short bowel syndrome can crop up if more than 50% of small intestine is resected or when less than 100 cm of small bowel is left. Glutamine is the main food source of enterocytes. Curcumin has protective effects on intestinal ischemia-reperfusion damage. Nesfatin-1 is a satiety molecule. It has protective effects on gastric mucosa. The primary purpose of this study is to compare effects of glutamine, curcumin, and nesfatin-1 on the gastric serosal surface neomucosa formation on rats. Materials and Methods...
2016: Gastroenterology Research and Practice
Hoang Van Nong, Le Xuan Hung, Pham Nam Thang, Vu Duc Chinh, Le Van Vu, Phan Tien Dung, Tran Van Trung, Pham Thu Nga
In this report, we present the research results on using the conventional method and microwave technology to extract curcuminoid from turmeric roots originated in different regions of Northern Vietnam. This method is simple, yet economical, non-toxic and still able to achieve high extraction performance to get curcuminoid from turmeric roots. The detailed results on the Raman vibration spectra combined with X-ray powder diffraction and high-performance liquid chromatography/mass spectrometry allowed the evaluation of each batch of curcumin crystalline powder sample received, under the conditions of applied fabrication technology...
2016: SpringerPlus
Gary N Asher, Ying Xie, Ruin Moaddel, Mitesh Sanghvi, Katina S S Dossou, Angela D M Kashuba, Robert S Sandler, Roy L Hawke
Curcumin is poorly absorbed driving interest in new preparations. However, little is known about pharmacokinetics and tissue bioavailability between formulations. In this randomized, crossover study we evaluated the relationship between steady-state plasma and rectal tissue curcuminoid concentrations using standard and phosphatidylcholine curcumin extracts. There was no difference in the geometric mean plasma AUCs when adjusted for the 10-fold difference in curcumin dose between the two formulations. Phosphatidylcholine curcumin extract yielded only 20-30% plasma demethoxycurcumin and bisdemethoxycurcumin conjugates compared to standard extract, yet yielded 20-fold greater hexahydrocurcumin...
August 9, 2016: Journal of Clinical Pharmacology
Md Kausar Raza, Koushambi Mitra, Abhijith Shettar, Uttara Basu, Paturu Kondaiah, Akhil R Chakravarty
Platinum(ii) complexes, viz. [Pt(L)(cur)] (1), [Pt(L)(py-acac)] (2) and [Pt(L)(an-acac)] (3), where HL is 4,4'-bis-dimethoxyazobenzene, Hcur is curcumin, Hpy-acac and Han-acac are pyrenyl and anthracenyl appended acetylacetone, were prepared, characterized and their anticancer activities were studied. Complex [Pt(L)(acac)] (4) was used as a control. Complex 1 showed an absorption band at 430 nm (ε = 8.8 × 10(4) M(-1) cm(-1)). The anthracenyl and pyrenyl complexes displayed bands near 390 nm (ε = 3.7 × 10(4) for 3 and 4...
August 16, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Kazunori Kadota, Daiki Okamoto, Hideyuki Sato, Satomi Onoue, Shigeyuki Otsu, Yuichi Tozuka
The tri-component system curcumin/α-glucosyl stevia (Stevia-G)/polyvinylpyrrolidone (PVP) was developed to improve the oral bioavailability and physicochemical properties of curcumin (CUR). The tri-component CUR formulation with Stevia-G and PVP was prepared with freeze-drying. The tri-component CUR system exhibited 13,000-fold higher solubility of CUR than the equilibrium solubility of CUR for 24h, indicating a stable tri-composite structure involving CUR. CUR could be converted into an amorphous form in the presence of Stevia-G and PVP by freeze-drying...
December 15, 2016: Food Chemistry
Magdalena Szymusiak, Xiaoyu Hu, Paola A Leon Plata, Paulina Ciupinski, Zaijie Jim Wang, Ying Liu
Curcumin is a bioactive molecule extracted from Turmeric roots that has been recognized to possess a wide variety of important biological activities. Despite its great pharmacological activities, curcumin is highly hydrophobic, which results in poor bioavailability. We have formulated this hydrophobic compound into stable polymeric nanoparticles (nano-curcumin) to enhance its oral absorption. Pharmacokinetic analysis after oral delivery of nano-curcumin in mice demonstrated approximately 20-fold reduction in dose requirement when compared to unformulated curcumin to achieve comparable plasma and central nervous system (CNS) tissue concentrations...
September 10, 2016: International Journal of Pharmaceutics
Takahiro Harigae, Kiyotaka Nakagawa, Taiki Miyazawa, Nao Inoue, Fumiko Kimura, Ikuo Ikeda, Teruo Miyazawa
PURPOSE: Curcumin (CUR), the main polyphenol in turmeric, is poorly absorbed and rapidly metabolized following oral administration, which severely curtails its bioavailability. Poly-(lactic-co-glycolic acid)-based CUR nanoparticles (CUR-NP) have recently been suggested to improve CUR bioavailability, but this has not been fully verified. Specifically, no data are available about curcumin glucuronide (CURG), the major metabolite of CUR found in the plasma following oral administration of CUR-NP...
2016: International Journal of Nanomedicine
Sha Zhang, Xiaoyong Wang
The role of vesicle-to-micelle transition has been investigated in the interactions of phospholipid vesicles, phospholipid/sodium cholate (NaC) mixed vesicles, and phospholipid/NaC mixed micelles with curcumin in aqueous solution. The addition of NaC causes phospholipid vesicles to transit into phospholipid/NaC mixed vesicles and phospholipid/NaC mixed micelles. Turbidity measurement reveals that the presence of curcumin increases the NaC concentration for the solubilization of phospholipid vesicles, which indicates that the bound curcumin tends to suppress the vesicle-to-micelle transition...
August 4, 2016: Journal of Physical Chemistry. B
Arul Prakash Francis, Sundara Ramaprabhu, Thiyagarajan Devasena
Intravenous route is the best strategy to accomplish fastest and highest delivery of drugs. Hydrophobic drugs like curcumin and its analog exhibit disadvantages like low bioavailability, poor absorption and rapid precipitation on intravenous delivery, all leading to its poor therapeutic value. These can be by-passed by enhancing the dispersity, stability and decreasing the size of the drug by nanotization. Thus, with an intention to deliver bis-demethoxy curcumin analog via intravenous route, we have studied the effect of DMSO, ethanol and acetone on the size, size distribution, stability and yield and identified the best solvent in terms of smallest size, narrow size distribution, more stability and high yield of nano bis-demethoxy curcumin analog (NBDMCA)...
January 2016: Journal of Nanoscience and Nanotechnology
Dandan Liu, Jinyu Li, Hao Pan, Fengwei He, Zhidong Liu, Qingyin Wu, Chunping Bai, Shihui Yu, Xinggang Yang
The transient precorneal retention time and low penetration capacity into intraocular tissues are the key obstacles that hinder the ophthalmic drug delivery of many therapeutic compounds, especially for drugs with poor solubility and permeability. To break the stalemate, N-acetyl-L-cysteine functionalized chitosan copolymer (CS-NAC), which exhibit marked bioadhesion and permeation enhancing effect, was synthesized. The curcumin encapsulated NLC (CUR-NLC) was produced and optimized followed by surface absorption of CS-NAC...
2016: Scientific Reports
Ana Catalan-Latorre, Maryam Ravaghi, Maria Letizia Manca, Carla Caddeo, Francesca Marongiu, Guido Ennas, Elvira Escribano-Ferrer, José Esteban Peris, Octavio Diez-Sales, Anna Maria Fadda, Maria Manconi
This work aimed at finding an innovative vesicle-type formulation able to improve the bioavailability of curcumin upon oral administration. To this purpose, phospholipid, Eudragit® S100 and hyaluronan sodium salt were combined to obtain eudragit-hyaluronan immobilized vesicles using an easy and environmentally-friendly method. For the first time, the two polymers were combined in a system intended for oral delivery, to enhance curcumin stability when facing the harsh environment of the gastrointestinal tract...
October 2016: European Journal of Pharmaceutics and Biopharmaceutics
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