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vih clinical trial

James G Bittner, Kevin El-Hayek, Andrew T Strong, Melissa Phillips LaPinska, Jin S Yoo, Eric M Pauli, Matthew Kroh
BACKGROUND: Mesh options for reinforcement of ventral/incisional hernia (VIH) repair include synthetic or biologic materials. While each material has known advantages and disadvantages, little is understood about outcomes when these materials are used in combination. This multicenter study reports on the first human use of a novel synthetic/biologic hybrid mesh (Zenapro® Hybrid Hernia Repair Device) for VIH repair. METHODS: This prospective, multicenter post-market clinical trial enrolled consecutive adults who underwent elective VIH repair with hybrid mesh placed in the intraperitoneal or retromuscular/preperitoneal position...
March 2018: Surgical Endoscopy
José Côté, Gaston Godin, Yann-Gaël Guéhéneuc, Geneviève Rouleau, Pilar Ramirez-Garcìa, Joanne Otis, Cécile Tremblay, Ghayas Fadel
BACKGROUND: Living with HIV makes considerable demands on a person in terms of self-management, especially as regards adherence to treatment and coping with adverse side-effects. The online HIV Treatment, Virtual Nursing Assistance and Education (Virus de I'immunodéficience Humaine-Traitement Assistance Virtuelle Infirmière et Enseignement; VIH-TAVIE™) intervention was developed to provide persons living with HIV (PLHIV) with personalized follow-up and real-time support in managing their medication intake on a daily basis...
October 5, 2012: Trials
Vivian M Sanchez, Youmna E Abi-Haidar, Kamal M F Itani
BACKGROUND: Prosthetic mesh infection is a catastrophic complication of ventral incisional hernia (VIH) repair. METHODS: The current surgical literature was reviewed to determine the incidence, microbiology, risk factors, and treatment of mesh infections. RESULTS: Mesh infections tend to present late. Diagnosis depends on high clinical suspicion and relies on culture of the fluid surrounding the mesh or of the mesh itself. Risk factors may include a high body mass index (obesity); chronic obstructive pulmonary disease; abdominal aortic aneurysm repair; prior surgical site infection; use of larger, microporous, or expanded polytetrafluoroethylene mesh; performance of other procedures via the same incision at the time of repair; longer operative time; lack of tissue coverage of the mesh; enterotomy; and enterocutaneous fistula...
June 2011: Surgical Infections
José Tomás Ramos, María Isabel de José, Rosa Polo, Claudia Fortuny, María José Mellado, María Angeles Muñoz-Fernández, José Beceiro, José María Bertrán, Cristina Calvo, Lourdes Chamorro, Luis Ciria, Sara Guillén, Raúl González-Montero, María Isabel González-Tomé, María Dolores Gurbindo, Pablo Martín-Fontelos, Jorge Martínez-Pérez, David Moreno, María Carmen Muñoz-Almagro, Antonio Mur, María Luisa Navarro, Carmen Otero, Pablo Rojo, Bárbara Rubio, Jesús Saavedra
OBJECTIVE: To update antiretroviral recommendations in antiretroviral therapy (ART) in HIV-infected children and adolescents. METHODS: Theses guidelines have been formulated by a panel of members of the Plan Nacional sobre el SIDA (PNS) and the Asociacion Espanola de Pediatria (AEP) by reviewing the current available evidence of efficacy, safety, and pharmacokinetics in pediatric studies. Three levels of evidence have been defined according to the source of data: Level A: randomized and controlled studies; Level B: Cohort and case-control studies; Level C: Descriptive studies and experts' opinion...
May 2005: Enfermedades Infecciosas y Microbiología Clínica
Kamal M F Itani, Leigh Neumayer, Domenic Reda, Lawrence Kim, Thomas Anthony
The appearance of incisional hernia after laparotomy closure continues to be an important postoperative complication. Advances in anesthesia techniques, adequate prevention and treatment of infection during surgery, and the use of new suture materials have reduced the incidence of incisional hernia. Nevertheless, incisional hernia still occurs in 0.5% to 11% of all laparotomies performed. There are many different techniques currently in use for ventral incisional hernia (VIH) repair. Among these techniques, laparoscopic repair has been reported to be superior to open repair because of less pain, a lower recurrence rate, fewer complications, and earlier return to work...
December 2004: American Journal of Surgery
M Cartoux, P Msellati, N Meda, C Welffens-Ekra, L Mandelbrot, V Leroy, P Van de Perre, F Dabis
OBJECTIVE: To evaluate the attitude of pregnant women towards HIV testing in two cities of West Africa: Abidjan, Côte d'Ivoire and Bobo-Dioulasso, Burkina Faso. METHODS: In the context of a clinical trial to prevent HIV vertical transmission, HIV counselling and testing was offered systematically to women attending antenatal clinics. Informed consent was obtained and test results were given anonymously. Multiple logistic regression was performed to identify factors associated with refusal for testing and failure to return for test results...
December 3, 1998: AIDS
J Martín Fernández, R Rubio García, F Pulido Ortega
The zidovudine (ZDV) was the first drug approved to treat the VIH infection. The ZDV prescriptions have been changing throughout the years. Actually it's known that its efficacy is limited over time, and same substances have been discovered which inhibtes more strongly the VIH replication. However the ZDV appears in majority the combined therapy regimens as a first line drug. Even in same special situations there is no existence of another antiretroviral drugs which have showed utility. In this essay it s revised the mainly studies which have provided new knowledge about the ZDV treatment and it s also considered the possibilities of this drug in the more new therapies against the VIH...
March 1998: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
M J Hervas Laguna, J A Nieto Rodríguez, M P Geijo Martínez, M D Ruiz Ribo, S Borregón
PML affects 4% of patients with AIDS and there is no effective treatment. Five cases of PML-AIDS have been described, showing clinical and radiological improvement after treatment with C-ara. We describe the case of a 33-year-old woman, addict to heroin, her clinical record including VIH infection, pneumonia by P. carinii, milliary tuberculosis, infection by virus B and C and treatment with AZT and tuberculostatics since January, 1992. In May, she began to develop a cerebellar syndrome. Images obtained with nuclear magnetic resonance were typical of PML...
May 1994: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
M Girard, G Pialoux
Much progress has been made in recent years in the development of anti-VIH vaccines. Nearly 20 such vaccines have reached phase 1 clinical study in seronegative volunteers. The responses invoked by these vaccines are, however, mediocre, both in quality (lack of cross over neutralisation in isolated "wild" viruses) and in their levels and length of action. New formulations of vaccines are under study, but their development is long and difficult, and researchers are still disarmed by the problem of the variability of the virus...
June 15, 1995: La Revue du Praticien
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