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https://www.readbyqxmd.com/read/29332930/bullosis-diabeticorum-a-rare-presentation-with-immunoglobulin-g-igg-deposition-related-vasculopathy-case-report-and-focused-review
#1
Hardik Sonani, Sohail Abdul Salim, Vishnu V Garla, Anna Wile, Venkataraman Palabindala
BACKGROUND Bullosis diabeticorum (BD) is a condition characterized by recurrent, spontaneous, and non-inflammatory blistering in patients with poorly controlled diabetes mellitus. While etiopathogenesis remains unclear, roles of neuropathy, vasculopathy and UV light are hypothesized. Most literature reports negative direct and indirect immunofluorescence findings in diabetics with bullous eruptions. Porphyria cutanea tarda, bullous pemphigoid, epidermolysis bullosa, and pseudoporphyria are other differential diagnoses of bullous lesions, and they must be excluded...
January 15, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29329666/advances-in-self-healing-materials-based-on-vascular-networks-with-mechanical-self-repair-characteristics
#2
REVIEW
Min Wook Lee, Seongpil An, Sam S Yoon, Alexander L Yarin
Here, we review the state-of-the-art in the field of engineered self-healing materials. These materials mimic the functionalities of various natural materials found in the human body (e.g., the healing of skin and bones by the vascular system). The fabrication methods used to produce these "vascular-system-like" engineered self-healing materials, such as electrospinning (including co-electrospinning and emulsion spinning) and solution blowing (including coaxial solution blowing and emulsion blowing) are discussed in detail...
December 24, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/29327699/nail-changes-in-autoimmune-blistering-disorders-a-case-control-study
#3
Vaishnavi Gopal, Manjunath Mala Shenoy, Vishal Bejai, Thansiha Nargis
BACKGROUND: Pemphigus and pemphigoid disorders produce blistering cutaneous lesions. Earlier case reports state that nail involvement is uncommon in these autoimmune blistering disorders. AIMS AND OBJECTIVES: To study nail changes in autoimmune blistering disorders. METHODS: A case-control study was conducted where 40 cases and 40 controls were evaluated for nail changes. RESULTS: Nail changes were seen in 72.5% of cases and 17...
January 12, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29326825/staphylococcal-scalded-skin-syndrome-a-pediatric-dermatology-case-report
#4
Girish Gulab Meshram, Neeraj Kaur, Kanwaljeet Singh Hura
Staphylococcal scalded skin syndrome is a condition which predominantly affects children and causes a spectrum of skin lesions. We present a case of a 2-month-old infant with complaints of fever and fragile blisters over the body. The mucosal areas were spared. The diagnosis of staphylococcal scalded skin syndrome was reached on clinical grounds and culture report. The patient responded well to the treatment, which included an antibiotic (cloxacillin), an analgesic (paracetamol), and hydration with intravenous fluids...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29325955/endovascular-patch-embolization-for-blood-blister-like-aneurysms-in-the-dorsal-segment-of-the-internal-carotid-artery
#5
Xudong Hao, Guilin Li, Jian Ren, Jingwei Li, Chuan He, Hong-Qi Zhang
OBJECTIVE: Blood blister-like aneurysms (BBAs) in the dorsal segment of the internal carotid artery (ICA) are fragile and difficult to treat, and the optimal treatment for BBAs is still controversial. We report clinical and angiographic results with procedural details for the treatment of BBA by using the endovascular patch embolization method. METHODS: We retrospectively reviewed patients who presented with subarachnoid hemorrhage(SAH) caused by ICA-BBAs and were treated with the endovascular patch embolization method in our center from October 2011 to March 2015...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29324427/lemons-in-the-arizona-sunshine-the-effects-of-furocoumarins-leading-to-phytophotodermatitis-and-burn-like-injuries
#6
Marc R Matthews, Joel C VanderVelde, Daniel M Caruso, Kevin N Foster
INTRODUCTION: Phytophototoxic dermatitis is a strong phototoxic reaction to ultraviolet A (UV-A) radiation exposure after cutaneous contact with citrus fruit containing furocoumarins, leading to skin injury. At the Arizona Burn Center (Phoenix, AZ), the majority of these injuries are managed in the outpatient setting. CASE REPORT: The authors present a pediatric admission for burn-like injuries following prolonged cutaneous exposure to lemons while playing in the Arizona sunshine...
December 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29322633/preclinical-evaluation-of-melanocyte-transplantation-by-chitosan-based-melanocyte-spheroid-patch-to-skin-prepared-by-controlled-sunburn-blistering
#7
Sabrina Mai-Yi Fan, Po-Hua Chen, Yu-Ting Tseng, Jin-Bon Hong, Wannhsin Chen, Tsen-Fang Tsai, Sung-Jan Lin
Transplantation of autologous cultured melanocytes as cell suspension has been used for the treatment of vitiligo. The recipient site is often prepared by laser-mediated dermabrasion. Such procedures encounter disadvantages including prolonged transplantation duration, unsecured cell adherence to lesional skin and potential scarring. To improve this, here we propose a method by preparing recipient sites before transplantation by psoralen and ultraviolet A (PUVA)-induced sunburn followed by transplanting cells with a chitosan-based melanocyte spheroid patch...
January 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29316366/impact-of-radiation-therapy-on-scleroderma-and-cancer-outcomes-in-scleroderma-patients-with-breast-cancer
#8
Dhaval J Shah, Ram Hirpara, Corrie L Poelman, Adrianne Woods, Laura K Hummers, Fredrick M Wigley, Jean L Wright, Arti Parekh, Virginia D Steen, Robyn T Domsic, Ami A Shah
OBJECTIVES: We examined SSc patients with breast cancer to 1) identify the prevalence of radiation complications and 2) examine SSc outcomes in SSc patients who received radiation therapy (RT) as part of their cancer treatment. METHODS: Patients with SSc and breast cancer were identified from the Johns Hopkins and University of Pittsburgh Scleroderma Center databases. We examined whether erythema, blistering, ulceration, or thickening of the skin developed in the RT port...
January 5, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29316016/non-invasive-measurement-of-reepithelialization-and-microvascularity-of-suction-blister-wounds-with-benchmarking-to-histology
#9
Heidi Fhaer Larsen, Malin Glindvad Ahlström, Lise Mette Rahbek Gjerdrum, Mette Mogensen, Khaled Ghathian, Henrik Calum, Anne Lyngholm Sørensen, Julie Lyng Forman, Mark Vandeven, Marian N Holerca, Laurence Du-Thumm, Lars Nannestad Jorgensen, Magnus S Ågren
We explored use of the suction-blister wound model in the assessment of not only epidermal regeneration but also pain, the microvascular response and bacteriology. The effects of topical zinc sulfate were studied to articulate the methodologies in this double-blind trial. One epidermal suction blister (10 mm) was induced on each buttock in 30 healthy volunteers (15 females:15 males) and de-roofed on day 0. The wounds were randomized to daily treatment with 1.4% zinc sulfate shower gel (n = 20), placebo (n = 20) or control (n = 20)...
January 8, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29310928/sofosbuvir-and-velpatasvir-for-hepatitis-c-virus-infection-in-people-with-recent-injection-drug-use-simplify-an-open-label-single-arm-phase-4-multicentre-trial
#10
Jason Grebely, Olav Dalgard, Brian Conway, Evan B Cunningham, Philip Bruggmann, Behzad Hajarizadeh, Janaki Amin, Julie Bruneau, Margaret Hellard, Alain H Litwin, Philippa Marks, Sophie Quiene, Sharmila Siriragavan, Tanya L Applegate, Tracy Swan, Jude Byrne, Melanie Lacalamita, Adrian Dunlop, Gail V Matthews, Jeff Powis, David Shaw, Maria Christine Thurnheer, Martin Weltman, Ian Kronborg, Curtis Cooper, Jordan J Feld, Chris Fraser, John F Dillon, Phillip Read, Ed Gane, Gregory J Dore
BACKGROUND: Despite revised guidelines that no longer exclude people who inject drugs (PWID) from treatment for hepatitis C virus (HCV) infection, many clinicians are reluctant to treat recent PWID. This study aimed to evaluate the efficacy of sofosbuvir and velpatasvir therapy in people with chronic HCV infection and recent injection drug use. METHODS: In this open-label, single-arm phase 4 trial (SIMPLIFY), we recruited participants with recent injection drug use (past 6 months) and chronic HCV genotype 1-6 infection from seven countries (19 sites)...
January 5, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29301743/blisters-in-disguise
#11
E A Dowlatshahi, Gfh Diercks, Mba van Doorn
No abstract text is available yet for this article.
January 4, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29300852/progeny-density-and-nest-availability-affect-parasitism-risk-and-reproduction-in-a-solitary-bee-osmia-lignaria-hymenoptera-megachilidae
#12
Shahla Farzan
Gregarious nesting behavior occurs in a broad diversity of solitary bees and wasps. Despite the prevalence of aggregative nesting, the underlying drivers and fitness consequences of this behavior remain unclear. I investigated the effect of two key characteristics of nesting aggregations (cavity availability and progeny density) on reproduction and brood parasitism rates in the blue orchard bee (Osmia lignaria Say) (Hymenoptera: Megachilidae), a solitary species that nests gregariously and appears to be attracted to nesting conspecifics...
December 30, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/29299693/picosecond-532-nm-neodymium-doped-yttrium-aluminum-garnet-laser-a-promising-modality-for-the-management-of-verrucous-epidermal-nevi
#13
Assi Levi, Dan Ben Amitai, Daniel Mimouni, Yael A Leshem, Ofir Arzi, Moshe Lapidoth
The verrucous epidermal nevus (VEN) is the most common type of epidermal nevi. As lesions can be disfiguring, treatment is often sought. Many therapeutic approaches have been reported, with variable efficacy and safety. Picosecond (PS) lasers are novel laser devices designated to target small chromophores. A side effect of these lasers is blistering due to epidermal-dermal separation. We aimed to harness this side effect of the PS lasers to treat patients with VEN. The purpose of this study was to report our experience treating VEN using a PS 532-nm laser...
January 3, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29299431/a-review-on-botanicals-with-wound-healing-activity-for-pemphigus-vulgaris-perspective-of-traditional-persian-medicine-and-conventional-medicine
#14
REVIEW
Fatemeh Atarzadeh, Amir Mohammad Jaladat, Babak Daneshfard, Ladan Dastgheib, Mohammad Kamalinejad, Gholamreza Amin
Objective: As a rare autoimmune disease, pemphigus vulgaris has a poor prognosis especially in lack of proper medical support. This blistering disease involves both the skin and mucus membranes. The challenge is improving the healing process of skin lesions of which, superimposed infections are among the main causes of the disease mortality. Accordingly, we aimed to assess the treatment options suggested by traditional Persian medicine (TPM) and compare them with current findings. Materials and Methods: We studied the main clinical and pharmaceutical textbooks of TPM (Kitāb al-hāwīfī al-tibb, the Canon of Medicine, Eksir-e-Aazam, Tuhfat al-mu'minīn, Makhzan al-adviyah (focusing on the skin chapter and respective herbal remedies for the inflamed skin and ulcers...
November 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29295765/absolute-ethanol-embolization-combined-with-surgical-resection-of-scalp-arteriovenous-malformations-interim%C3%A2-results
#15
Yifeng Han, Xindong Fan, Lixin Su, Zhenfeng Wang
PURPOSE: To assess treatment methods, interim results, and complications of absolute ethanol embolization combined with surgical resection of scalp arteriovenous malformations (AVMs). MATERIALS AND METHODS: From September 2012 to January 2015, 15 consecutive patients (8 male and 7 female) with scalp AVMs underwent staged ethanol embolizations. Ethanol embolization was performed using transcatheter and/or direct puncture techniques. Ten patients with scalp AVMs with a dominant outflow vein (DOV) also underwent coil deployment before ethanol embolization...
December 30, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29291236/clinical-characteristics-of-hand-foot-and-mouth-disease-in-daklak-province-vietnam-and-associated-factors-of-severe-cases
#16
Hau Van Pham, Tuan N A Hoang, Hao T Duong, Lan T Phan, Uyen T N Phan, Nguyen X Ho, Cuong Q Hoang
The Hand, Foot and Mouth Disease (HFMD) outbreaks occurred throughout Daklak province, Vietnam in 2011. This study reviewed all 744 medical records of HFMD patients admitted to Daklak Hospital in 2011 to describe the clinical characteristics of HFMD patients and determined factors associated with severe illness. Among 744 patients, 63 (8.5%) cases were severe. Most (695, 93.4%) of the cases were 3 years old or younger, and 464 (62.4%) were boys. The number of cases peaked between August and November. Most (726, 97...
December 2017: Virusdisease
https://www.readbyqxmd.com/read/29289926/the-use-of-suction-blisters-to-measure-sunscreen-protection-against-uvr-induced-dna-damage
#17
Gwendal Josse, Thierry Douki, Jimmy Le Digabel, Eleonore Gravier, Emmanuel Questel
The formation of DNA photoproducts caused by solar UVR exposure needs to be investigated in-vivo and in particular in order to assess sunscreens' level of protection against solar genotoxicity. The study's purposes were: i) to evaluate if the roof of suction blisters is an appropriate sampling method for measuring photoproducts, and ii) to measure in-vivo sunscreen protection against cyclobutane pyrimidine dimers. Skin areas on the interior forearms of eight healthy volunteers were exposed in-vivo to 2 MED of simulated solar radiation (SSR) and to 15 MED on a sunscreen protected area...
December 22, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29284701/more-than-bar-codes-integrating-global-standards-based-bar-code-technology-into-national-health-information-systems-in-ethiopia-and-pakistan-to-increase-end-to-end-supply-chain-visibility
#18
Liuichi Hara, Ramy Guirguis, Keith Hummel, Monica Villanueva
The United Nations Population Fund (UNFPA) and the United States Agency for International Development (USAID) DELIVER PROJECT work together to strengthen public health commodity supply chains by standardizing bar coding under a single set of global standards. From 2015, UNFPA and USAID collaborated to pilot test how tracking and tracing of bar coded health products could be operationalized in the public health supply chains of Ethiopia and Pakistan and inform the ecosystem needed to begin full implementation...
December 28, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/29282761/heparin-induced-haemorrhagic-bullous-dermatosis
#19
S C Snow, D R Pearson, R Fathi, T Alkousakis, C Y Winslow, L Golitz
BACKGROUND: Heparin-induced haemorrhagic bullous dermatosis (HBD) is a rare but probably underdiagnosed reaction to heparin, with 26 cases reported in the English literature. Currently, there is no consensus regarding the treatment. AIM: To assess our new cases of HBD and review the previously reported cases, in order to draw conclusions about this adverse skin reaction to heparin. METHODS: A PubMed search was performed for articles containing the terms '(heparin-induced AND (blister OR bulla OR bullae)) OR (hemorrhagic bullous dermatosis AND heparin) OR heparin bullous dermatosis'...
December 27, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29278440/a-novel-lateral-flow-immunoassay-for-the-rapid-detection-of-anti-dsg3-igg-serum-autoantibodies-in-pemphigus-vulgaris
#20
Thomas Schmidt, Susanne Mauracher, Lena Bender, Brandon Greene, Jonas Kurzhals, Rüdiger Eming, Ralf Dostatni, Michael Hertl
Pemphigus vulgaris (PV) is a severe autoimmune blistering disease of the skin and mucous membranes. As autoantibodies play an essential role in the disease pathogenesis, the serological detection of anti-desmoglein 3 IgG represents a central tool in the diagnosis of the disease. In this study, we show the validation of a novel lateral flow immunoassay (LFIA) which rapidly detects anti-desmoglein 3 (Dsg3) IgG in human serum. In contrast to other diagnostic procedures, the assay is compact and simple to perform and delivers a fast "yes" or "no" answer within 10 min without additional hardware requirements for test evaluation...
December 26, 2017: Experimental Dermatology
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