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Cerebrospinal fluid-contacting nucleus

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https://www.readbyqxmd.com/read/28803831/localization-of-connexin-43-gap-junctions-and-hemichannels-in-tanycytes-of-adult-mice
#1
Anett Szilvásy-Szabó, Edina Varga, Zsuzsa Beliczai, Ronald M Lechan, Csaba Fekete
Tanycytes are specialized glial cells lining the lateral walls and the floor of the third ventricle behind the optic chiasm. In addition to functioning as barrier cells, they also have an important role in the regulation of neuroendocrine axes and energy homeostasis. To determine whether tanycytes communicate with each other via Connexin 43 (Cx43) gap junctions, individual tanycytes were loaded with Lucifer yellow (LY) through a patch pipette. In all cases, LY filled a larger group of tanycytes as well as blood vessels adjacent to tanycyte processes...
August 10, 2017: Brain Research
https://www.readbyqxmd.com/read/28793053/cerebrospinal-fluid-contacting-nucleus-mediates-nociception-via-release-of-fractalkine
#2
Q Q Zhou, S S Chen, Q Q Zhang, P F Liu, H Z Fang, Y Yang, L C Zhang
Increasing evidence suggests that the cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) mediates the transduction and regulation of pain signals. However, the precise molecular mechanisms remain unclear. Studies show that release of fractalkine (FKN) from neurons plays a critical role in nerve injury-related pain. We tested the hypothesis that release of FKN from the CSF-contacting nucleus regulates neuropathic pain, in a chronic constriction injury rat model. The results show that FKN is expressed by neurons, via expression of its only receptor CX3CR1 in the microglia...
August 7, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28791699/restricted-co-localization-of-glutamate-and-dopamine-in-neurons-of-the-adult-sea-lamprey-brain
#3
B Fernández-López, D Sobrido-Cameán, R Anadón, M C Rodicio, A Barreiro-Iglesias
Co-localization of dopamine with other classical neurotransmitters in the same neuron is a common phenomenon in the brain of vertebrates. In mammals, some dopaminergic neurons of the ventral tegmental area and the hypothalamus have a glutamatergic co-phenotype. However, information on the presence of this type of dopaminergic neurons in other vertebrate groups is very scant. Here, we aimed to provide new insights on the evolution of this neuronal co-phenotype by studying the presence of a dual dopaminergic/glutamatergic neuron phenotype in the central nervous system of lampreys...
August 8, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28673711/activation-of-p2x3-receptors-in-the-cerebrospinal-fluid-contacting-nucleus-neurons-reduces-formalin-induced-pain-behavior-via-pag-in-a-rat-model
#4
Peng-Fei Liu, Hong-Zhi Fang, Yan Yang, Qing-Qing Zhang, Qiang-Qiang Zhou, Song-Song Chen, Fang Zhou, Li-Cai Zhang
The cerebrospinal fluid (CSF)-contacting nucleus is implicated in the descending inhibitory pathway in pain processing, whereas the cellular and molecular mechanisms underpinning CSF-contacting nucleus regulating pain signals remains largely elusive. ATP is evidenced to inhibit pain transmission at supraspinal level by the mediation of the receptor P2X, wherein its subtype P2X3 is identified as the most potent. Our present experiment investigated the functionality of P2X3 receptors in CSF-contacting nucleus in the formalin-evoked inflammatory pain...
June 30, 2017: Neuroscience
https://www.readbyqxmd.com/read/28440440/involvement-of-neurokinin-1-receptor-within-the-cerebrospinal-fluid%C3%A2-contacting-nucleus-in-visceral-pain
#5
Chao Zhang, Ying Li, Xin Wang, Yan Fei, Licai Zhang
Studies have shown that the cerebrospinal fluid‑contacting nucleus (CSF‑CN) may be associated with the transduction and regulation of pain signals. However, the role of the CSF‑CN remains to be elucidated. Emerging evidence has suggested that neurokinin 1 receptor (NK1R) is important in the development of visceral pain and hyperalgesia, however, whether NK1R exists in the CSF‑CN and its exact role in visceral pain remain to be fully elucidated. In the present study, double‑labeled immunofluorescence staining and western blot analysis were performed to investigate this...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26961890/role-of-the-rvm-in-descending-pain-regulation-originating-from-the-cerebrospinal-fluid-contacting-nucleus
#6
Yan Fei, Xin Wang, Songsong Chen, Qiangqiang Zhou, Chao Zhang, Ying Li, Lihong Sun, Licai Zhang
Evidence has suggested that cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) is correlated with the development and recurrence of pain. A recent research showed that the CSF-contacting nucleus acts as a component of the descending 5-hydroxytryptamine (5-HT) system and plays a role in descending pain inhibition. However, limited studies are conducted to investigate the relationship between the CSF-contacting nucleus and pain. In present study, we explored the effect of CSF-contacting nucleus on nociceptive behaviors in both normal and neuropathic rats via targeted ablation of the CSF-contacting nucleus in the brainstem, using cholera toxin subunit B-saporin (CB-SAP), a cytotoxin coupled to cholera toxin subunit B...
July 2016: Neurochemical Research
https://www.readbyqxmd.com/read/26701634/-phosphorylation-of-protein-kinase-c-in-cerebrospinal-fluid-contacting-nucleus-modulates-the-inflammatory-pain-in-rats
#7
Fang Zhou, Jia-You Wang, En-Qi Tian, Li-Cai Zhang
The present study was aimed to investigate the role of cerebrospinal fluid-contacting nucleus (CSF-CN) neurons in modulation of inflammatory pain and underlying mechanism. The inflammatory pain model was made by subcutaneous injection of the complete Freund's adjuvant (CFA) into the left hind paw of rats. The phosphorylation level of PKC (p-PKC) was examined by Western blot. Thermal withdrawal latency (TWL) of the rats was measured to assess inflammatory pain. The results showed that, compared with the sham controls, the inflammatory pain model rats showed shortened TWL on day 1, 3, and 7 after CFA injection, as well as increased level of p-PKC in CSF-CN neurons at 24 h after CFA injection...
December 25, 2015: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/26606020/extracellular-signal-regulated-kinase-5-in-the-cerebrospinal-fluid-contacting-nucleus-contributes-to-neuropathic-pain-in-rats
#8
Chun-Guang Wang, Si-Yuan Song, Yan-Ling Ding, Shu-Qin Guo, Xin Liu, Shi Hao, Xin Li, Na Chen, Yu Zhang, Li-Cai Zhang
BACKGROUND: The activation of mitogen-activated protein kinases (MAPKs) have been observed in synaptic plasticity processes of learning and memory in neuropathic pain. Cerebrospinal fluid-contacting nucleus (CSF-CN) has been identified with the onset and persistence of neuropathic pain. However, whether extracellular signal-regulated protein kinase 5 (ERK5), a member of MAPKs, in CSF-CN participates in neuropathic pain has not been studied yet. OBJECTIVE: The aim of the present study was to identify the role of ERK5 in CSF-CN on the formation and development of neuropathic pain, and to investigate its possible mechanism...
November 2015: Pain Physician
https://www.readbyqxmd.com/read/25911494/role-of-adrenomedullin-in-the-cerebrospinal-fluid-contacting-nucleus-in-the-modulation-of-immobilization-stress
#9
Yue-Hong Wu, Si-Yuan Song, He Liu, Dan Xing, Xin Wang, Yan Fei, Guang-Ling Li, Chao Zhang, Ying Li, Li-Cai Zhang
The contribution of the cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) and adrenomedullin (ADM) to the developmental modulation of stressful events remains controversial. This study explored the effects of endogenous ADM in the CSF-contacting nucleus on immobilization of stress-induced physiological parameter disorders and glucocorticoid hormone releasing hormone (CRH), rat plasma corticosterone expression, and verification of such effects by artificially lowering ADM expression in the CSF-contacting nucleus by targeted ablation of the nucleus...
June 2015: Neuropeptides
https://www.readbyqxmd.com/read/25911266/role-of-cerebrospinal-fluid-contacting-nucleus-in-sodium-sensing-and-sodium-appetite
#10
Dan Xing, Yuehong Wu, Guangling Li, Siyuan Song, Yuepeng Liu, He Liu, Xing Wang, Yan Fei, Chao Zhang, Ying Li, Licai Zhang
The brainstem plays an important role in controlling sodium and water homeostasis. It is a major regulatory site for autonomic and motor functions. Moreover, it integrates cerebrospinal fluid (CSF) signals with neuronal and hormonal signals. Evidence suggests that the CSF-contacting nucleus (CSF-CN) transmits and integrates CSF signals, but, the definitive role of CSF-CN in sodium homeostasis is poorly understood. In this study, we used c-Fos as a marker of neuronal activity and causing colocalization of Nax channel and 5-HT...
August 1, 2015: Physiology & Behavior
https://www.readbyqxmd.com/read/25846007/mtor-and-erk1-2-signaling-in-the-cerebrospinal-fluid-contacting-nucleus-is-involved-in-neuropathic-pain
#11
Guangling Li, Xianfu Lu, Suming Zhang, Qiangqiang Zhou, Licai Zhang
The cerebrospinal fluid-contacting nucleus (CSF-CN) has been demonstrated to be involved in neuropathic pain, but the underlying molecular mechanisms remain unclear. Previous work has shown that mTOR and ERK1/2 are important signaling pathways regulating neuropathic pain. However, studies on the interactions between these major pathways in neuropathic pain are very rare. Therefore, the purpose of this study is to determine whether mTOR and ERK1/2 exist in the CSF-CN and elucidate their alterations in neuropathic pain, especially, the crosstalk between them...
May 2015: Neurochemical Research
https://www.readbyqxmd.com/read/25672631/-the-distribution-of-map-kinase-phosphatase-1-in-the-cerebrospinal-fluid-contacting-nucleus-and-its-functional-contribution-to-depressive-behaviors
#12
Ping Chen, Qing-Song Lin, Li-Cai Zhang
The purpose of this research is to explore the distribution and expression of MAP kinase phosphatase-1 (MKP-1) in cerebrospinal fluid (CSF)-contacting nucleus in depression, and provide experimental evidence to reveal the biological function and regulatory mechanisms of CSF-contacting nucleus in depression. Depression model was produced by chronic forced swimming stress (CFSS) in Sprague-Dawley (SD) rats. Intracerebroventricular injection of cholera toxin subunit B (CTb) labeled with horseradish peroxidase (CB-HRP) was used to specifically mark distal CSF-contacting nucleus...
February 25, 2015: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/25244785/-targeted-damage-of-the-cerebrospinal-fluid-contacting-nucleus-contributes-to-the-pain-behavior-and-the-expression-of-5-ht-and-c-fos-in-spinal-dorsal-horn-of-rats
#13
Jing Cao, Tong Wu, Li-Cai Zhang
OBJECTIVE: The changes of pain threshold and expression of 5-hydroxytryptamine(5-HT) and c-Fos in spinal dorsal horn of rats were observed after targetedly damaged the cerebraspinal fluid-contacting nucleus (CSF-contacting nucleus) to provide experimental evidence for the mechanism of regulating pain CSF-contacting nucleus involved in. METHODS: Male adult SD rats were divided into control, sham, choleratoxin subunit B conjugated with horse-radish peroxidase (CB-HRP)and damage groups randomly...
May 2014: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/25108066/role-of-the-cerebrospinal-fluid-contacting-nucleus-in-the-descending-inhibition-of-spinal-pain-transmission
#14
He Liu, Wei-Wei Yan, Xiao-Xing Lu, Xiu-Li Zhang, Jing-Qiu Wei, Xiao-Yu Wang, Tiao Wang, Tong Wu, Jing Cao, Cui-Jie Shao, Fang Zhou, Hong-Xing Zhang, Peng Zhang, Ting Zang, Xian-Fu Lu, Jun-Li Cao, Hai-Lei Ding, Li-Cai Zhang
The brainstem is well recognized as a critical site for integrating descending modulatory systems that both inhibit and facilitate pain at the level of the spinal cord. The cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) distributes and localizes in the ventral periaqueductal central gray of the brainstem. Although emerging lines of evidence suggest that the CSF-contacting nucleus may be closely linked to transduction and regulation of pain signals, the definitive role of the CSF-contacting nucleus in pain modulation remains poorly understood...
November 2014: Experimental Neurology
https://www.readbyqxmd.com/read/24964850/-neuropathic-pain-enhances-expression-of-hcn2-channel-in-rat-cerebrospinal-fluid-contacting-nucleus
#15
Tong Wu, Jing Cao, Li-Cai Zhang
The purpose of this research is to explore the distribution and expression of hyperpolarization-activated cyclic nucleotide-gated channels subtype 2 (HCN2) in cerebrospinal fluid (CSF)-contacting nucleus in neuropathic pain, and provide experimental evidence to reveal the biological function and regulation mechanisms of CSF-contacting nucleus in neuropathic pain. Neuropathic pain model was produced by chronic constriction injury (CCI) in Sprague-Dawley (SD) rats. Intracerebroventricular injection of cholera toxin subunit B (CTb) labeled with horseradish peroxidase (CB-HRP) was used to specifically mark distal CSF-contacting nucleus...
June 25, 2014: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/24959116/universality-and-diversity-in-the-signal-transduction-pathway-that-regulates-seasonal-reproduction-in-vertebrates
#16
REVIEW
Yusuke Nakane, Takashi Yoshimura
Most vertebrates living outside the tropical zone show robust physiological responses in response to seasonal changes in photoperiod, such as seasonal reproduction, molt, and migration. The highly sophisticated photoperiodic mechanism in Japanese quail has been used to uncover the mechanism of seasonal reproduction. Molecular analysis of quail mediobasal hypothalamus (MBH) revealed that local thyroid hormone activation within the MBH plays a critical role in the photoperiodic response of gonads. This activation is accomplished by two gene switches: thyroid hormone-activating (DIO2) and thyroid hormone-inactivating enzymes (DIO3)...
2014: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/24738716/involvement-of-wnt5a-within-the-cerebrospinal-fluid-contacting-nucleus-in-nerve-injury-induced-neuropathic-pain
#17
Jinfeng Wang, Suming Zhang, Li Li, Licai Zhang
Studies have demonstrated that the cerebrospinal fluid-contacting nucleus (CSF-CN) is involved in neuropathic pain, but the underlying molecular mechanisms still largely remain obscure. Emerging evidence suggests that spinal Wnt5a plays a crucial role in regulation of chronic pain. However, little is known about the potential role of the supraspinal Wnt5a in the development of chronic pain. To investigate whether Wnt5a exists in the CSF-CN and its role in neuropathic pain, double-labeled immunofluorescence staining was used to identify the expression of Wnt5a in the CSF-CN and western blot analysis of the CSF-CN was employed to verify the alteration of Wnt5a protein in the process of neuropathic pain...
February 2015: International Journal of Neuroscience
https://www.readbyqxmd.com/read/24512021/asic3-in-the-cerebrospinal-fluid-contacting-nucleus-of-brain-parenchyma-contributes-to-inflammatory-pain-in-rats
#18
X Y Wang, W W Yan, X L Zhang, H Liu, L C Zhang
OBJECTIVE: The study explores the role of acid-sensitive ion channel 3 (ASIC3) in the cerebrospinal fluid (CSF)-contacting nucleus of the parenchyma of rat brain, in inflammatory pain. METHODS: We injected rats subcutaneously with complete Freund's adjuvant (CFA) into the plantar surface of the left hind paw. We then measured the thermal withdrawal latency (TWL) and mechanical withdrawal threshold (MWT). After horseradish peroxidase-conjugated toxin subunit B (CB-HRP) retrograde tracing of one of the rats' lateral ventricles, we used immunohistochemistry, to observe the distribution and expression of ASIC3 in CSF-contacting nucleus with double labeling of CB-HRP and ASIC3...
March 2014: Neurological Research
https://www.readbyqxmd.com/read/24157104/primary-tumors-of-the-lateral-ventricles-of-the-brain
#19
L Dănăilă
BACKGROUND: The lateral ventricles are located in the center of the brain. Each ventricle lies in contact with five critical neural structures: the caudate nucleus, the thalamus, the fornix, the corpus callosum, and the genu of internal capsule.The authors report their experience in primary tumors of the lateral ventricles of the brain by analysing the symptomatology,the surgical treatment, the complications and the postoperative results. OBJECTIVE: To determine the importance of the surgical technique on the morbidity and the recurrence of lateral ventricles tumors...
September 2013: Chirurgia
https://www.readbyqxmd.com/read/23981075/relationships-between-radial-glial-progenitors-and-5-ht-neurons-in-the-paraventricular-organ-of-adult-zebrafish-potential-effects-of-serotonin-on-adult-neurogenesis
#20
María Rita Pérez, Elisabeth Pellegrini, Joel Cano-Nicolau, Marie-Madeleine Gueguen, Dounia Menouer-Le Guillou, Yohann Merot, Colette Vaillant, Gustavo M Somoza, Olivier Kah
In non-mammalian vertebrates, serotonin (5-HT)-producing neurons exist in the paraventricular organ (PVO), a diencephalic structure containing cerebrospinal fluid (CSF)-contacting neurons exhibiting 5-HT or dopamine (DA) immunoreactivity. Because the brain of the adult teleost is known for its neurogenic activity supported, for a large part, by radial glial progenitors, this study addresses the origin of newborn 5-HT neurons in the hypothalamus of adult zebrafish. In this species, the PVO exhibits numerous radial glial cells (RGCs) whose somata are located at a certain distance from the ventricle...
November 2013: European Journal of Neuroscience
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